| Frazier Life Sciences Management, L.P. |
$613032889 |
18088902 |
15.23% |
股份
|
| Capital World Investors |
$414493577 |
12230557 |
10.30% |
股份
|
| FMR LLC |
$350411179 |
10339663 |
8.70% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$323655973 |
9550191 |
8.04% |
股份
|
| FCPM III SERVICES B.V. |
$287738063 |
8490353 |
7.15% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$144533699 |
4264789 |
3.59% |
股份
|
| VIKING GLOBAL INVESTORS LP |
$142458886 |
4203567 |
3.54% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$129004522 |
3806566 |
3.20% |
股份
|
| MAVERICK CAPITAL LTD |
$110745810 |
3267802 |
2.75% |
股份
|
| Medicxi Ventures Management (Jersey) Ltd |
$74850776 |
2208639 |
1.86% |
股份
|
| JANUS HENDERSON GROUP PLC |
$72253603 |
2258984 |
1.79% |
股份
|
| JENNISON ASSOCIATES LLC |
$71246471 |
2102286 |
1.77% |
股份
|
| Orbis Allan Gray Ltd |
$59227079 |
1747627 |
1.47% |
股份
|
| Polar Capital Holdings Plc |
$58443915 |
1724518 |
1.45% |
股份
|
| Capital International Investors |
$58409246 |
1723495 |
1.45% |
股份
|
| GOLDMAN SACHS GROUP INC |
$52357034 |
1544911 |
1.30% |
股份
|
| WESTFIELD CAPITAL MANAGEMENT CO LP |
$52071036 |
1536472 |
1.29% |
股份
|
| Castle Hook Partners LP |
$46463359 |
1371005 |
1.15% |
股份
|
| AMERIPRISE FINANCIAL INC |
$42482886 |
1253549 |
1.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$40330679 |
1259940 |
1.00% |
股份
|
| JPMORGAN CHASE & CO |
$38373185 |
1132955 |
0.95% |
股份
|
| Aberdeen Group plc |
$37373384 |
1102785 |
0.93% |
股份
|
| BlackRock, Inc. |
$36050487 |
1063750 |
0.90% |
股份
|
| FRANKLIN RESOURCES INC |
$33683835 |
993917 |
0.84% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$26472835 |
781140 |
0.66% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$25564142 |
754327 |
0.63% |
股份
|
| Woodline Partners LP |
$25501852 |
752489 |
0.63% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$24925518 |
735483 |
0.62% |
股份
|
| TimesSquare Capital Management, LLC |
$24071136 |
751988 |
0.60% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$23208343 |
684813 |
0.58% |
股份
|
| CITADEL ADVISORS LLC |
$21886331 |
645805 |
0.54% |
股份
|
| Jefferies Financial Group Inc. |
$20334000 |
600000 |
0.51% |
卖出期权
|
| Rock Springs Capital Management LP |
$19749194 |
582744 |
0.49% |
股份
|
| First Turn Management, LLC |
$19740823 |
582497 |
0.49% |
股份
|
| MORGAN STANLEY |
$19514724 |
575825 |
0.48% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$19269854 |
568600 |
0.48% |
卖出期权
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$18639500 |
550000 |
0.46% |
股份
|
| Artia Global Partners LP |
$17078391 |
503936 |
0.42% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$16999698 |
501614 |
0.42% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$16945000 |
500000 |
0.42% |
卖出期权
|
| Cormorant Asset Management, LP |
$16945000 |
500000 |
0.42% |
股份
|
| JANE STREET GROUP, LLC |
$16071858 |
474236 |
0.40% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$14280365 |
421374 |
0.35% |
股份
|
| Bank of New York Mellon Corp |
$11973270 |
353298 |
0.30% |
股份
|
| UBS Group AG |
$11660363 |
344065 |
0.29% |
股份
|
| Slate Path Capital LP |
$10810910 |
319000 |
0.27% |
股份
|
| ExodusPoint Capital Management, LP |
$10313879 |
304334 |
0.26% |
股份
|
| Eversept Partners, LP |
$9335712 |
275471 |
0.23% |
股份
|
| Affinity Asset Advisors, LLC |
$9319750 |
275000 |
0.23% |
股份
|
| SEB Asset Management AB |
$9240226 |
272654 |
0.23% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$9131973 |
285285 |
0.23% |
股份
|
| Atle Fund Management AB |
$8433458 |
248848 |
0.21% |
股份
|
| GILDER GAGNON HOWE & CO LLC |
$7593732 |
224070 |
0.19% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$7413404 |
218749 |
0.18% |
股份
|
| LMR Partners LLP |
$7269405 |
214500 |
0.18% |
卖出期权
|
| Ensign Peak Advisors, Inc |
$7199015 |
212423 |
0.18% |
股份
|
| ArrowMark Colorado Holdings LLC |
$7179359 |
211843 |
0.18% |
股份
|
| DEUTSCHE BANK AG\ |
$6775662 |
199931 |
0.17% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6156932 |
181674 |
0.15% |
股份
|
| VANGUARD GROUP INC |
$6067297 |
172956 |
0.15% |
股份
|
| Decheng Capital LLC |
$5994700 |
176887 |
0.15% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$5851549 |
172663 |
0.15% |
股份
|
| PEREGRINE CAPITAL MANAGEMENT LLC |
$5743948 |
169488 |
0.14% |
股份
|
| Point72 Asset Management, L.P. |
$5724055 |
168901 |
0.14% |
股份
|
| AXA Investment Managers S.A. |
$5596480 |
196782 |
0.14% |
股份
|
| Mizuho Markets Cayman LP |
$5101767 |
150539 |
0.13% |
股份
|
| TD Asset Management Inc |
$5029276 |
148400 |
0.12% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5015720 |
148000 |
0.12% |
买入期权
|
| XTX Topco Ltd |
$4914321 |
145008 |
0.12% |
股份
|
| Jump Financial, LLC |
$4897512 |
144512 |
0.12% |
股份
|
| DCF Advisers, LLC |
$4778490 |
141000 |
0.12% |
股份
|
| KORNITZER CAPITAL MANAGEMENT INC /KS |
$4742329 |
139933 |
0.12% |
股份
|
| Cutter Capital Management, LP |
$4526981 |
221152 |
0.11% |
股份
|
| Jefferies Financial Group Inc. |
$4159252 |
122728 |
0.10% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$4107468 |
121200 |
0.10% |
卖出期权
|
| Swiss National Bank |
$4104079 |
121100 |
0.10% |
股份
|
| D. E. Shaw & Co., Inc. |
$4085812 |
120561 |
0.10% |
股份
|
| ADAR1 Capital Management, LLC |
$4020133 |
118623 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$4003934 |
118145 |
0.10% |
股份
|
| STATE STREET CORP |
$3904636 |
115215 |
0.10% |
股份
|
| Walleye Capital LLC |
$3789546 |
111819 |
0.09% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$3562287 |
105169 |
0.09% |
股份
|
| Swedbank AB |
$3527949 |
104100 |
0.09% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$3261302 |
96232 |
0.08% |
股份
|
| NORTHERN TRUST CORP |
$3184677 |
93971 |
0.08% |
股份
|
| Caption Management, LLC |
$3124658 |
92200 |
0.08% |
卖出期权
|
| Squarepoint Ops LLC |
$3118761 |
92026 |
0.08% |
股份
|
| Moody Aldrich Partners LLC |
$3071010 |
90617 |
0.08% |
股份
|
| Schonfeld Strategic Advisors LLC |
$3042135 |
89765 |
0.08% |
股份
|
| Bellevue Group AG |
$2948227 |
86994 |
0.07% |
股份
|
| ALGERT GLOBAL LLC |
$2756613 |
81340 |
0.07% |
股份
|
| Man Group plc |
$2739396 |
80832 |
0.07% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$2692899 |
79460 |
0.07% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$2648029 |
78136 |
0.07% |
股份
|
| STEMPOINT CAPITAL LP |
$2629491 |
77589 |
0.07% |
股份
|
| Headlands Technologies LLC |
$2451433 |
72335 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2284796 |
67418 |
0.06% |
股份
|
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
$2145169 |
63298 |
0.05% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$2015675 |
59477 |
0.05% |
股份
|
| Russell Investments Group, Ltd. |
$1989578 |
58707 |
0.05% |
股份
|
| China Universal Asset Management Co., Ltd. |
$1647223 |
48605 |
0.04% |
股份
|
| Qube Research & Technologies Ltd |
$1595880 |
47090 |
0.04% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$1528947 |
45115 |
0.04% |
股份
|
| Palo Alto Investors LP |
$1503327 |
44359 |
0.04% |
股份
|
| Knights of Columbus Asset Advisors LLC |
$1484382 |
43800 |
0.04% |
股份
|
| FIRST TRUST ADVISORS LP |
$1460930 |
43108 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1437682 |
42422 |
0.04% |
股份
|
| Fieldview Capital Management, LLC |
$1418025 |
41842 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$1385017 |
40868 |
0.03% |
股份
|
| Legal & General Group Plc |
$1333336 |
39343 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$1301376 |
38400 |
0.03% |
买入期权
|
| Ishara Investments LP |
$1250541 |
36900 |
0.03% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1211771 |
35756 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1210212 |
35710 |
0.03% |
股份
|
| LMR Partners LLP |
$1155649 |
34100 |
0.03% |
买入期权
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1123759 |
33159 |
0.03% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1118336 |
32999 |
0.03% |
股份
|
| STIFEL FINANCIAL CORP |
$1079432 |
31851 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$1062621 |
31355 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$1036797 |
30593 |
0.03% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$916725 |
27050 |
0.02% |
股份
|
| Eleva Capital SAS |
$823329 |
25721 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$768998 |
22691 |
0.02% |
股份
|
| HighVista Strategies LLC |
$708470 |
20905 |
0.02% |
股份
|
| GLENMEDE TRUST CO NA |
$692033 |
20420 |
0.02% |
股份
|
| DNB Asset Management AS |
$680850 |
20090 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$661838 |
19529 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$661465 |
19518 |
0.02% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$647265 |
19099 |
0.02% |
股份
|
| Caption Management, LLC |
$633743 |
18700 |
0.02% |
买入期权
|
| Point72 Asset Management, L.P. |
$620187 |
18300 |
0.02% |
买入期权
|
| Point72 Asset Management, L.P. |
$620187 |
18300 |
0.02% |
卖出期权
|
| WELLS FARGO & COMPANY/MN |
$611308 |
18038 |
0.02% |
股份
|
| GOLDMAN SACHS GROUP INC |
$576130 |
17000 |
0.01% |
买入期权
|
| ARIZONA STATE RETIREMENT SYSTEM |
$564472 |
16656 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$534581 |
15774 |
0.01% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$525973 |
15520 |
0.01% |
股份
|
| SBI Okasan Asset Management Co.Ltd. |
$504663 |
14900 |
0.01% |
股份
|
| AlphaCentric Advisors LLC |
$503877 |
14868 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$487000 |
14362 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$464293 |
13700 |
0.01% |
股份
|
| KEYBANK NATIONAL ASSOCIATION/OH |
$422947 |
12480 |
0.01% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$406714 |
12001 |
0.01% |
股份
|
| PSP Research LLC |
$406680 |
12000 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$406680 |
12000 |
0.01% |
买入期权
|
| PTM WEALTH MANAGEMENT, LLC |
$382356 |
12900 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$364758 |
10763 |
0.01% |
股份
|
| Financiere des Professionnels - Fonds d'investissement inc. |
$364114 |
10744 |
0.01% |
股份
|
| Cerity Partners LLC |
$340967 |
10061 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$328123 |
9682 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$323582 |
9548 |
0.01% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$321108 |
9475 |
0.01% |
股份
|
| BAMCO INC /NY/ |
$305010 |
9000 |
0.01% |
股份
|
| AdvisorNet Financial, Inc |
$283829 |
8375 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$277051 |
8175 |
0.01% |
股份
|
| Creative Planning |
$275695 |
8135 |
0.01% |
股份
|
| BARCLAYS PLC |
$273560 |
8072 |
0.01% |
股份
|
| CITIGROUP INC |
$272001 |
8026 |
0.01% |
股份
|
| Mesirow Financial Investment Management, Inc. |
$252989 |
7465 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$247397 |
7300 |
0.01% |
卖出期权
|
| PNC Financial Services Group, Inc. |
$247091 |
7291 |
0.01% |
股份
|
| US BANCORP \DE\ |
$246922 |
7286 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$246855 |
7284 |
0.01% |
股份
|
| Wealth Management Associates, Inc. |
$239094 |
7055 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$237501 |
7008 |
0.01% |
股份
|
| Centiva Capital, LP |
$237230 |
7000 |
0.01% |
股份
|
| Invesco Ltd. |
$224250 |
6617 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$223674 |
6600 |
0.01% |
股份
|
| CIBC Private Wealth Group LLC |
$217282 |
7640 |
0.01% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$216896 |
6400 |
0.01% |
股份
|
| MARSHALL FINANCIAL GROUP INC /ADV |
$213300 |
7500 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$177177 |
5228 |
0.00% |
股份
|
| Quarry LP |
$153996 |
4544 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$152505 |
4500 |
0.00% |
股份
|
| Mitsubishi UFJ Trust & Banking Corp |
$146744 |
4330 |
0.00% |
股份
|
| WELLS FARGO & COMPANY/MN |
$128782 |
3800 |
0.00% |
卖出期权
|
| Duquesne Family Office LLC |
$104047 |
3070146 |
0.00% |
股份
|
| Quantbot Technologies LP |
$91300 |
2694 |
0.00% |
股份
|
| Toroso Investments, LLC |
$84192 |
2400 |
0.00% |
买入期权
|
| GF FUND MANAGEMENT CO. LTD. |
$82488 |
2434 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$61431 |
1813 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$60494 |
1785 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$47446 |
1400 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$43278 |
1277 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$39562 |
1167357 |
0.00% |
股份
|
| THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. |
$36160 |
1067 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$34093 |
1006 |
0.00% |
股份
|
| CWM, LLC |
$32586 |
1018 |
0.00% |
股份
|
| Cheviot Value Management, LLC |
$26976 |
796 |
0.00% |
股份
|
| NWI MANAGEMENT LP |
$23791 |
702000 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$20842 |
615 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$13409 |
418900 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$11856 |
349843 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$11014 |
325 |
0.00% |
股份
|
| LORD, ABBETT & CO. LLC |
$10389 |
306560 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$9150 |
270 |
0.00% |
股份
|
| FIL Ltd |
$7354 |
217 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$7083 |
209 |
0.00% |
股份
|
| Arax Advisory Partners |
$6032 |
178 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$5584 |
168 |
0.00% |
股份
|
| Continuum Advisory, LLC |
$5219 |
154 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$4710 |
139 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$2576 |
76 |
0.00% |
股份
|
| ORG Partners LLC |
$2104 |
60 |
0.00% |
股份
|
| Essential Partners LLC |
$1796 |
53 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$921 |
45 |
0.00% |
股份
|
| Allworth Financial LP |
$848 |
25 |
0.00% |
股份
|
| True Wealth Design, LLC |
$712 |
21 |
0.00% |
股份
|
| FIDUCIARY FINANCIAL ADVISORS |
$441 |
13 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$373 |
11 |
0.00% |
股份
|
| GAMMA Investing LLC |
$305 |
9 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$256 |
8 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$115 |
3384 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$102 |
3 |
0.00% |
股份
|
| IFP Advisors, Inc |
$102 |
3 |
0.00% |
股份
|
| KBC Group NV |
$84 |
2483 |
0.00% |
股份
|
| DUPONT CAPITAL MANAGEMENT CORP |
$34 |
1 |
0.00% |
股份
|