BLTE — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Darwin Global Management, Ltd. | $456,588,244 | 3,077,219 | 32.41% | Shares |
| Paradigm Biocapital Advisors LP | $189,844,565 | 1,232,877 | 13.48% | Shares |
| RTW INVESTMENTS, LP | $110,150,398 | 715,332 | 7.82% | Shares |
| MILLENNIUM MANAGEMENT LLC | $76,155,438 | 494,564 | 5.41% | Shares |
| MAVERICK CAPITAL LTD | $61,025,949 | 396,311 | 4.33% | Shares |
| EVENTIDE ASSET MANAGEMENT, LLC | $60,181,804 | 390,829 | 4.27% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $55,003,288 | 357,199 | 3.90% | Shares |
| Holocene Advisors, LP | $38,655,624 | 251,035 | 2.74% | Shares |
| Logos Global Management LP | $38,496,250 | 250,000 | 2.73% | Shares |
| MORGAN STANLEY | $36,197,407 | 235,071 | 2.57% | Shares |
| UBS Group AG | $34,644,931 | 224,989 | 2.46% | Shares |
| CITADEL ADVISORS LLC | $28,667,080 | 186,168 | 2.03% | Shares |
| GOLDMAN SACHS GROUP INC | $25,590,459 | 166,188 | 1.82% | Shares |
| Affinity Asset Advisors, LLC | $25,407,525 | 165,000 | 1.80% | Shares |
| MPM BIOIMPACT LLC | $21,127,974 | 137,208 | 1.50% | Shares |
| BANK OF AMERICA CORP /DE/ | $19,214,710 | 124,783 | 1.36% | Shares |
| Patient Square Capital LP | $16,938,350 | 110,000 | 1.20% | Shares |
| JANE STREET GROUP, LLC | $10,132,367 | 65,801 | 0.72% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $8,796,393 | 57,125 | 0.62% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $8,586,666 | 55,763 | 0.61% | Shares |
| Point72 Asset Management, L.P. | $7,881,877 | 51,186 | 0.56% | Shares |
| Soleus Capital Management, L.P. | $7,779,938 | 50,524 | 0.55% | Shares |
| Trexquant Investment LP | $7,624,721 | 49,516 | 0.54% | Shares |
| TWO SIGMA INVESTMENTS, LP | $5,866,829 | 38,100 | 0.42% | Shares |
| PFM Health Sciences, LP | $5,359,140 | 34,803 | 0.38% | Shares |
| JPMORGAN CHASE & CO | $5,131,442 | 33,181 | 0.36% | Shares |
| Walleye Capital LLC | $4,884,558 | 31,721 | 0.35% | Shares |
| Artia Global Partners LP | $3,847,931 | 24,989 | 0.27% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $3,486,220 | 22,640 | 0.25% | Shares |
| BALANCE CAPITAL PARTNERS L.P. | $3,464,663 | 22,500 | 0.25% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $3,079,700 | 20,000 | 0.22% | Shares |
| STATE STREET CORP | $2,452,057 | 15,924 | 0.17% | Shares |
| Verdad Advisers, LP | $2,118,526 | 13,758 | 0.15% | Shares |
| ORBIMED ADVISORS LLC | $2,048,001 | 13,300 | 0.15% | Shares |
| TD Asset Management Inc | $2,003,345 | 13,010 | 0.14% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $1,960,691 | 12,733 | 0.14% | Shares |
| Qube Research & Technologies Ltd | $1,874,151 | 12,171 | 0.13% | Shares |
| Lighthouse Investment Partners, LLC | $1,539,850 | 10,000 | 0.11% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1,512,133 | 9,820 | 0.11% | Shares |
| HighVista Strategies LLC | $1,471,173 | 9,554 | 0.10% | Shares |
| Squarepoint Ops LLC | $1,352,758 | 8,785 | 0.10% | Shares |
| BARCLAYS PLC | $1,050,486 | 6,822 | 0.07% | Shares |
| Capricorn Fund Managers Ltd | $985,504 | 6,400 | 0.07% | Shares |
| Voleon Capital Management LP | $968,412 | 6,289 | 0.07% | Shares |
| SmartHarvest Portfolios, LLC | $671,221 | 4,359 | 0.05% | Shares |
| XTX Topco Ltd | $667,217 | 4,333 | 0.05% | Shares |
| Mariner, LLC | $590,533 | 3,835 | 0.04% | Shares |
| Entropy Technologies, LP | $569,745 | 3,700 | 0.04% | Shares |
| High Net Worth Advisory Group LLC | $538,948 | 3,500 | 0.04% | Shares |
| FMR LLC | $477,354 | 3,100 | 0.03% | Shares |
| AMERIPRISE FINANCIAL INC | $466,421 | 3,029 | 0.03% | Shares |
| Engineers Gate Manager LP | $427,000 | 2,773 | 0.03% | Shares |
| Yeomans Consulting Group, Inc. | $383,744 | 2,399 | 0.03% | Shares |
| Virtus Investment Advisers, LLC | $364,790 | 2,369 | 0.03% | Shares |
| Cubist Systematic Strategies, LLC | $344,100 | 4,650 | 0.02% | Shares |
| FRED ALGER MANAGEMENT, LLC | $326,294 | 2,119 | 0.02% | Shares |
| Jain Global LLC | $323,522 | 2,101 | 0.02% | Shares |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $309,202 | 2,008 | 0.02% | Shares |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | $292,572 | 1,900 | 0.02% | Shares |
| GAMMA Investing LLC | $259,619 | 1,686 | 0.02% | Shares |
| R Squared Ltd | $206,032 | 1,338 | 0.01% | Shares |
| Independent Advisor Alliance | $203,106 | 1,319 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $72,373 | 470 | 0.01% | Shares |
| ROYAL BANK OF CANADA | $50,000 | 322 | 0.00% | Shares |
| Bayforest Capital Ltd | $47,273 | 307 | 0.00% | Shares |
| WELLS FARGO & COMPANY/MN | $19,094 | 124 | 0.00% | Shares |
| E Fund Management (Hong Kong) Co., Ltd. | $17,400 | 113 | 0.00% | Shares |
| Duquesne Family Office LLC | $16,338 | 106,100 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $16,301 | 105,859 | 0.00% | Shares |
| CITIGROUP INC | $7,237 | 47 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $4,759 | 32 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $3,388 | 22 | 0.00% | Shares |
| Rossby Financial, LCC | $3,080 | 20 | 0.00% | Shares |
| WEST PACES ADVISORS INC. | $2,772 | 18 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $2,618 | 17 | 0.00% | Shares |
| Bell Investment Advisors, Inc | $2,002 | 13 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $924 | 6 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $672 | 4,364 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $616 | 4 | 0.00% | Shares |
| FIDUCIARY FINANCIAL ADVISORS | $462 | 3 | 0.00% | Shares |
| Arax Advisory Partners | $308 | 2 | 0.00% | Shares |
| SG Americas Securities, LLC | $141 | 913 | 0.00% | Shares |