Soleus Capital Management, L.P.

CIK 1802630 · View on SEC EDGAR ↗

Portfolio value
$2.9B
#1,196 of 9,443 by 13F value · top 12.7%
Positions
97
As of
June 30, 2026

Portfolio value QoQ: +17.5% 13F does not disclose cash

Top 10 holdings weight
48.91%
Top 25 holdings weight
72.19%
Positions above 1%
29
Effective number of positions
27.0

Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)

Turnover Q2 2026: 28.95% Est. buys $777,526,622 · sells $927,740,678

Median holding: 3.0 quarters Tracked Q4 2024–Q2 2026 · 49.2% still held

New positions
22
Increased
25
Decreased
41
Closed
18
On this page

Performance vs S&P 500

Tracked Q4 2024–Q2 2026
+109.9%
S&P 500 total return (same window)
+28.1%
Excess return
+81.8%

Annualized: +64.2% · S&P 500: +18.0%

Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.

Priceable coverage: 99.3% · Options excluded: 7.8%

Sector breakdown

Healthcare
97.8%
Other/Unmapped
2.2%

Full portfolio 97 positions

Type Streak 8Q trend
KRYS Krystal Biotech, Inc. - Common Stock $349,092,534 12.03% 939,254 $51,227,100 Down ×1
CELC Celcuity Inc. - Common Stock $178,305,749 6.14% 1,704,318 $31,706,844 Up ×1
TGTX TG Therapeutics, Inc. - Common Stock $160,858,551 5.54% 2,927,895 $27,004,574 Down ×1
PODD Insulet Corporation - Common Stock $159,710,250 5.50% 1,049,000 $41,675,250 Up ×2
NVCR NovoCure Limited - Ordinary Shares $150,188,025 5.18% 9,913,401 $35,820,963 Down ×1
UTHR United Therapeutics Corporation - Common Stock $122,229,804 4.21% 225,587 $11,231,657 Up ×2
INSP Inspire Medical Systems, Inc. Common Stock $86,161,360 2.97% 1,931,436 $56,435,858 Up ×2
RIGL Rigel Pharmaceuticals, Inc. - Common Stock $72,117,876 2.49% 1,843,504 $71,847,476 Up ×1
ANIP ANI Pharmaceuticals, Inc. - Common Stock $71,833,173 2.48% 867,760 $8,756,486 Up ×4
BBNX Beta Bionics, Inc. - Common Stock $68,849,498 2.37% 4,393,714 $25,217,398 Up ×2
VCEL Vericel Corporation - Common Stock $64,917,672 2.24% 1,459,152 $-17,086,199 Down ×1
PRAX Praxis Precision Medicines, Inc. - Common Stock $59,430,916 2.05% 177,517 $-47,058,356 Down ×5
GERN Geron Corporation - Common Stock $54,795,084 1.89% 42,808,659 $-7,052,818 Up ×5
ALKS Alkermes plc - Ordinary Shares $53,927,659 1.86% 1,029,252 $-15,762,092 Down ×1
ERAS Erasca, Inc. - Common Stock $49,464,000 1.70% 2,700,000
NPCE Neuropace, Inc. - Common Stock $46,257,729 1.59% 2,911,122 $7,699,207 Down ×1
PGNY Progyny, Inc. - Common Stock $46,185,660 1.59% 1,602,000 $11,088,000 Down ×1
INDV Indivior Pharmaceuticals, Inc. - Common Stock $43,655,920 1.50% 1,064,000 $4,824,400 Down ×1
Unknown issuer (CUSIP: 698955101) $40,098,966 1.38% 1,465,070 Up ×1
EDAP EDAP TMS S.A. - American Depositary Shares, each representing One Ordinary Share $37,861,936 1.30% 7,309,254 $10,671,511
GMED Globus Medical, Inc. Class A Common Stock $37,049,527 1.28% 468,922 $-25,801,350 Down ×2
RCUS Arcus Biosciences, Inc. Common Stock $36,032,193 1.24% 1,168,738 $26,269,360 Up ×1
SNDX Syndax Pharmaceuticals, Inc. - Common Stock $35,588,933 1.23% 1,628,039 $-4,751,638 Down ×2
NRIX Nurix Therapeutics, Inc. - Common stock $35,544,854 1.22% 1,465,163 $21,003,327 Up ×1
LEGN Legend Biotech Corporation - American Depositary Shares $34,800,400 1.20% 1,205,000 Up ×1
JBIO Jade Biosciences, Inc. - Common Stock $34,456,332 1.19% 1,550,690 $23,262,079 Up ×1
UNH UnitedHealth Group Incorporated Common Stock (DE) $33,250,400 1.15% 80,000
AVTX Avalo Therapeutics, Inc. - Common Stock $30,583,993 1.05% 1,654,978 $23,985,261 Up ×1
URGN UroGen Pharma Ltd. - Ordinary Shares $30,537,008 1.05% 829,810 $17,465,548 Up ×2
MBX MBX Biosciences, Inc. - Common Stock $28,443,401 0.98% 515,279 $23,103,326 Up ×1
PALI Palisade Bio, Inc. - Common Stock $27,303,106 0.94% 13,063,687 Up ×1
PHVS Pharvaris N.V. - Ordinary Shares $25,274,764 0.87% 730,907 $5,441,795 Up ×1
ORGO Organogenesis Holdings Inc. - Class A $24,642,511 0.85% 10,140,951 $738,807 Up ×2
SUPN Supernus Pharmaceuticals, Inc. - Common Stock $24,185,200 0.83% 520,000 Up ×1
PRCT PROCEPT BioRobotics Corporation - Common Stock $22,647,740 0.78% 1,003,000 $18,646,140 Up ×1
TNGX Tango Therapeutics, Inc. - Common Stock $22,163,340 0.76% 709,000 $12,749,340 Up ×2
IKT Inhibikase Therapeutics, Inc. - Common Stock $22,076,250 0.76% 10,875,000 $3,806,250
TRVI Trevi Therapeutics, Inc. - Common Stock $21,999,876 0.76% 1,179,618 $2,673,276 Down ×1
BMRN BioMarin Pharmaceutical Inc. - Common Stock $21,490,230 0.74% 375,572 $-15,260,582 Down ×2
LIVN LivaNova PLC - Ordinary Shares $20,965,114 0.72% 254,957 $-16,058,586 Down ×1
ARGX argenx SE - American Depositary Shares $18,513,650 0.64% 19,955 $15,957,775 Up ×1
NVCT Nuvectis Pharma, Inc. - Common Stock $18,390,000 0.63% 1,000,000 Up ×1
CAPR Capricor Therapeutics, Inc. - Common Stock $18,342,627 0.63% 761,737
EWTX Edgewise Therapeutics, Inc. - Common Stock $18,319,620 0.63% 450,889 $-27,352,703 Down ×1
PRLD Prelude Therapeutics Incorporated - Common Stock $18,006,755 0.62% 3,378,378 Up ×1
XENE Xenon Pharmaceuticals Inc. - Common Shares $16,116,120 0.56% 267,000 $-863,680 Down ×1
CCCC C4 Therapeutics, Inc. - Common Stock $15,775,171 0.54% 3,377,981 $5,770,804 Down ×1
KNSA Kiniksa Pharmaceuticals International, plc - Class A Ordinary Shares $15,754,274 0.54% 246,353 $-9,348,873 Down ×2
KIDS OrthoPediatrics Corp. - Common Stock $14,005,915 0.48% 732,144 $4,238,771 Up ×4
Unknown issuer (CUSIP: 05348Y105) $13,793,480 0.48% 419,000 Up ×1
BDSX Biodesix, Inc. - Common Stock $13,213,353 0.46% 585,958 $7,172,667 Up ×1
SYRE Spyre Therapeutics, Inc. - Common Stock $13,050,660 0.45% 147,000 Up ×1
TWST Twist Bioscience Corporation - Common Stock $10,764,232 0.37% 104,629 $-47,525,178 Down ×3
VIR Vir Biotechnology, Inc. - Common Stock $10,190,000 0.35% 1,000,000 $-7,747,920 Down ×1
ALNY Alnylam Pharmaceuticals, Inc. - Common Stock $9,949,042 0.34% 33,050 $-33,609,994 Down ×1
IMVT Immunovant, Inc. - Common Stock $9,709,560 0.33% 252,000 $3,996,360 Up ×1
INSM Insmed Incorporated - Common Stock $9,622,455 0.33% 90,250 $7,946,375 Up ×1
SEPN Septerna, Inc. - Common Stock $9,209,750 0.32% 275,000 $2,601,500
SOPH SOPHiA GENETICS SA - Ordinary Shares $9,030,050 0.31% 1,565,000 $-127,450 Down ×1
NKTR Nektar Therapeutics - Common Stock $8,960,951 0.31% 128,362 Up ×1
MIRM Mirum Pharmaceuticals, Inc. - common stock $8,780,250 0.30% 75,000 $-28,200,018 Down ×2
AORT Artivion, Inc. Common Stock $8,718,360 0.30% 388,000 Up ×1
TNDM Tandem Diabetes Care, Inc. - Common Stock $8,676,750 0.30% 575,000 $-6,333,360 Down ×1
ELVN Enliven Therapeutics, Inc. - Common Stock $8,408,108 0.29% 165,677 $-641,957 Down ×2
SION Sionna Therapeutics, Inc. - Common Stock $7,816,451 0.27% 177,687 $-3,949,964 Down ×1
BLTE Belite Bio, Inc - American Depositary Shares $7,779,938 0.27% 50,524
CERS Cerus Corporation - Common Stock $7,300,000 0.25% 2,500,000 $-12,271,734 Down ×1
SLN Silence Therapeutics Plc - American Depository Share $6,917,400 0.24% 630,000 Up ×1
Unknown issuer (CUSIP: 4525EP200) $6,916,500 0.24% 450,000 Up ×1
IVVD Invivyd, Inc. - Common Stock $6,725,093 0.23% 7,708,727 $-3,296,252
MRK Merck & Company, Inc. Common Stock (new) $6,425,000 0.22% 50,000 $-17,993,870 Down ×1
RLMD Relmada Therapeutics, Inc. - Common Stock $5,827,374 0.20% 842,106 $-33,684
GPCR Structure Therapeutics Inc. - American Depositary Shares $5,742,690 0.20% 107,000 $1,886,690 Up ×1
EOLS Evolus, Inc. - Common Stock $5,707,650 0.20% 822,428 $-3,520,780 Down ×1
ANL Adlai Nortye Ltd. - American Depositary Shares $4,663,515 0.16% 405,523 Up ×1
ZNTL Zentalis Pharmaceuticals, Inc. - common stock $4,607,500 0.16% 950,000 Up ×1
KPTI Karyopharm Therapeutics Inc. - Common Stock $4,298,800 0.15% 440,000 $1,848,000
CNTX Context Therapeutics Inc. - Common Stock $3,912,274 0.13% 7,063,141 $-14,331,155 Up ×1
LUNG Pulmonx Corporation - Common Stock $3,624,820 0.12% 2,788,323 $27,883
SABS SAB Biotherapeutics, Inc. - Common Stock $3,510,000 0.12% 900,000 $-511,500 Down ×1
TECX Tectonic Therapeutic, Inc. - Common Stock $3,495,388 0.12% 101,684 $-265,864 Down ×1
AXGN Axogen, Inc. - Common Stock $2,634,493 0.09% 57,036 $-19,866,409 Down ×3
MSLE Satellos Bioscience Inc. - Common Stock $2,444,141 0.08% 314,359 $111,300 Down ×1
AVBP ArriVent BioPharma, Inc. - Common Stock $1,737,000 0.06% 50,000 Up ×1
CORT Corcept Therapeutics Incorporated - Common Stock $1,708,828 0.06% 19,653 $-9,800,927 Down ×1
SLDB Solid Biosciences Inc. - Common Stock $1,498,500 0.05% 150,000 Up ×1
VCYT Veracyte, Inc. - Common Stock $1,468,250 0.05% 25,000 $-8,836,116 Down ×1
CGEM Cullinan Therapeutics, Inc. - Common Stock $910,500 0.03% 50,000 $-4,918,442 Down ×1
NSPR InspireMD Inc. - Common Stock $732,100 0.03% 1,045,708 $-972,404
WGS GeneDx Holdings Corp. - Class A Common Stock $686,500 0.02% 10,000
IOVA Iovance Biotherapeutics, Inc. - Common Stock $624,000 0.02% 150,000 $-2,886,000 Down ×1
LRMR Larimar Therapeutics, Inc. - Common Stock $573,711 0.02% 188,102 $-4,227,609 Down ×1
CGON CG Oncology, Inc. - Common stock $355,250 0.01% 5,000 $-998,350 Down ×3
QNRX Quoin Pharmaceuticals, Ltd. - American Depositary Shares $352,013 0.01% 72,730 $-128,005
EQ Equillium, Inc. - Common Stock $288,000 0.01% 90,000 Up ×1
NTRA Natera, Inc. - Common Stock $271,450 0.01% 1,000 $-23,527,360 Down ×1
NEO NeoGenomics, Inc. - Common Stock $145,900 0.01% 10,000 $-1,152,600 Down ×2

Conviction holdings

Positions increased for 3+ consecutive quarters.

Share counts are as reported in 13F filings (not split-adjusted)

Security Value % of portfolio Streak
ANIP $71,833,173 2.48% up ×4
GERN $54,795,084 1.89% up ×5
KIDS $14,005,915 0.48% up ×4

Biggest new bets

New positions opened this quarter, largest first.

Security Value Shares % of portfolio
ERAS $49,464,000 2,700,000 1.70%
Unknown issuer (CUSIP: 698955101) $40,098,966 1,465,070 1.38%
LEGN $34,800,400 1,205,000 1.20%
UNH $33,250,400 80,000 1.15%
PALI $27,303,106 13,063,687 0.94%
SUPN $24,185,200 520,000 0.83%
NVCT $18,390,000 1,000,000 0.63%
CAPR $18,342,627 761,737 0.63%
PRLD $18,006,755 3,378,378 0.62%
Unknown issuer (CUSIP: 05348Y105) $13,793,480 419,000 0.48%
SYRE $13,050,660 147,000 0.45%
NKTR $8,960,951 128,362 0.31%
AORT $8,718,360 388,000 0.30%
BLTE $7,779,938 50,524 0.27%
SLN $6,917,400 630,000 0.24%

Top movers (QoQ)

Security Action Shares Δ Value Δ
INSP Bought more +1.4M +$56.4M
KRYS Trimmed -214K +$51.2M
PRAX Trimmed -153K -$47.1M
PODD Bought more +486K +$41.7M
NVCR Trimmed -579K +$35.8M
ALNY Trimmed -99K -$33.6M
CELC Bought more +420K +$31.7M
MIRM Trimmed -325K -$28.2M
EWTX Trimmed -999K -$27.4M
TGTX Trimmed -1.1M +$27.0M

2 positions hidden (data completeness check)

Exited positions

Includes corporate events (mergers, delistings) — not all exits are sells

Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.

SecurityQuarter Shares before Value before Price since exit
XBI March 31, 2026 2,900,000 $353,597,000 No longer tracked
ELV Dec. 31, 2025 259,650 $83,898,108 14.0%
FOLD March 31, 2026 5,207,284 $74,151,724 No longer tracked
GSK March 31, 2026 639,000 $31,336,560 -6.3%
UNH Sept. 30, 2025 86,250 $26,907,413 12.2%
AZN March 31, 2025 409,000 $26,797,680 125.2%
RAPT March 31, 2026 764,000 $25,876,680 No longer tracked
NBIX March 31, 2026 175,982 $24,959,527 16.9%
GRFS Dec. 31, 2025 2,500,000 $24,900,000 -13.6%
QDEL March 31, 2025 547,082 $24,372,503 -58.8%
SRDX Sept. 30, 2025 789,060 $23,442,973 No longer tracked
TFX March 31, 2026 190,000 $23,187,600 12.8%
PCVX June 30, 2026 385,472 $22,399,778 7.2%
ICLR June 30, 2026 192,000 $21,246,720 -0.6%
IART Dec. 31, 2025 1,440,818 $20,646,922 32.9%
HUM Sept. 30, 2025 79,600 $19,460,608 47.6%
CAPR March 31, 2026 646,390 $18,654,815 -77.2%
HOLX June 30, 2025 302,000 $18,654,540 No longer tracked
THC March 31, 2026 92,500 $18,381,600 45.5%
ALNY March 31, 2025 76,800 $18,071,808 -14.9%
TVTX June 30, 2026 546,000 $16,221,660 14.4%
TAK March 31, 2025 1,180,000 $15,623,200 21.9%
ASND Sept. 30, 2025 85,000 $14,671,000 29.7%
SNY June 30, 2025 226,218 $12,546,050 -5.5%
QURE Dec. 31, 2025 200,000 $11,674,000 106.6%
THTX Sept. 30, 2025 4,801,376 $11,331,247 No longer tracked
ADMA Dec. 31, 2025 738,000 $10,819,080 -46.2%
ENOV Sept. 30, 2025 315,000 $9,878,400 -13.6%
LLY March 31, 2025 11,658 $8,999,976 51.3%
INBX June 30, 2026 131,000 $8,807,130 6.1%
DXCM June 30, 2026 140,000 $8,792,000 32.8%
TERN March 31, 2026 212,710 $8,593,484 No longer tracked
CDTX March 31, 2026 38,811 $8,572,962 No longer tracked
VSTM Dec. 31, 2025 935,909 $8,264,076 -10.0%
PTGX June 30, 2025 169,000 $8,172,840 174.7%
PCVX March 31, 2025 99,050 $8,108,233 65.0%
ERAS March 31, 2026 2,162,162 $8,043,243 9.0%
NUVL Dec. 31, 2025 88,000 $7,610,240 No longer tracked
TEVA June 30, 2025 450,500 $6,924,185 121.8%
CSTL March 31, 2025 252,917 $6,740,238 62.4%
BLTE March 31, 2026 40,354 $6,455,026 2.9%
ABVX March 31, 2026 45,000 $6,068,475 7.3%
ESTA Dec. 31, 2025 139,512 $5,718,597 -2.0%
MLTX March 31, 2026 400,000 $5,272,000 -14.9%
IMUX June 30, 2026 4,500,000 $4,995,000 7.4%
LIVN June 30, 2025 117,040 $4,597,331 73.8%
CALC March 31, 2026 683,904 $4,506,927 8.3%
VCEL March 31, 2025 80,696 $4,431,017 -5.8%
SRRK Sept. 30, 2025 125,000 $4,427,500 48.0%
CRNX March 31, 2025 85,000 $4,346,050 152.7%
ETON Dec. 31, 2025 200,000 $4,346,000 260.3%
CBLL Dec. 31, 2025 360,000 $4,136,400 9.2%
HROW Dec. 31, 2025 85,498 $4,119,294 -14.8%
ETON June 30, 2026 166,381 $4,106,283 68.3%
TNDM Sept. 30, 2025 200,000 $3,728,000 83.3%
SRPT June 30, 2025 58,000 $3,701,560 14.4%
WGS Sept. 30, 2025 40,000 $3,692,400 -24.5%
RCKT March 31, 2025 271,659 $3,414,754 -47.1%
AKRO Dec. 31, 2025 71,000 $3,371,080 No longer tracked
MURA Sept. 30, 2025 1,323,877 $3,269,976 No longer tracked
REPL March 31, 2025 262,500 $3,178,875 50.0%
CTMX Sept. 30, 2025 1,304,300 $2,960,761 6.0%
OFIX Sept. 30, 2025 261,147 $2,911,789 -33.0%
ESTA March 31, 2025 59,400 $2,736,558 75.0%
IDYA Dec. 31, 2025 100,000 $2,721,000 17.3%
DNLI Sept. 30, 2025 182,110 $2,547,719 73.3%
XENE Sept. 30, 2025 78,800 $2,466,440 49.9%
VKTX March 31, 2026 70,000 $2,462,600 7.0%
CBIO Dec. 31, 2025 200,000 $2,378,000 37.4%
RAPP Dec. 31, 2025 80,000 $2,376,000 58.6%
BLCO March 31, 2025 120,500 $2,176,230 18.8%
QDEL March 31, 2026 75,000 $2,142,000 -12.4%
IOVA Dec. 31, 2025 976,707 $2,119,454 229.1%
MRUS Sept. 30, 2025 40,000 $2,104,000 No longer tracked
MDXH March 31, 2025 851,688 $2,018,501 -49.2%
ACLX March 31, 2026 30,000 $1,956,000 No longer tracked
VTGN Dec. 31, 2025 550,000 $1,952,500 -62.7%
SKIN Sept. 30, 2025 1,000,000 $1,910,000 -68.0%
ARWR June 30, 2026 28,479 $1,785,633 8.2%
OLMA March 31, 2026 69,874 $1,746,850 -25.0%
ELVN March 31, 2025 75,405 $1,696,613 201.6%
BCAX March 31, 2026 100,000 $1,683,000 23.2%
KOD March 31, 2026 60,000 $1,677,600 5.2%
REGN March 31, 2025 2,300 $1,638,359 32.1%
MNKD Dec. 31, 2025 300,000 $1,611,000 -24.1%
YMAB Sept. 30, 2025 349,982 $1,578,419 No longer tracked
CTMX June 30, 2026 300,000 $1,410,000 -9.9%
IMUX Dec. 31, 2025 1,580,007 $1,392,934 2992.7%
ADVM Dec. 31, 2025 287,246 $1,301,224 No longer tracked
LQDA Dec. 31, 2025 50,000 $1,137,000 103.0%
WHWK March 31, 2025 333,227 $1,051,331 169.1%
EWTX Sept. 30, 2025 76,493 $1,002,823 170.6%
ABVX Sept. 30, 2025 125,000 $956,250 40.7%
GRAL March 31, 2026 11,000 $941,490 49.1%
GUTS March 31, 2026 400,000 $880,000 55.2%
VRDN March 31, 2025 45,500 $872,235 82.6%
SLNO Sept. 30, 2025 10,000 $837,800 No longer tracked
EPIX Dec. 31, 2025 4,362,026 $833,147 No longer tracked
BCYC Sept. 30, 2025 100,000 $695,000 -43.7%
MYO Dec. 31, 2025 704,275 $628,213 No longer tracked
MREO Dec. 31, 2025 299,711 $617,405 -29.0%
APGE June 30, 2025 16,000 $597,760 210.4%
TECX Dec. 31, 2025 25,000 $392,250 80.8%
COGT June 30, 2026 10,000 $384,900 -6.6%
TYRA June 30, 2026 10,000 $383,000 -17.4%
STAA June 30, 2026 20,000 $374,000 -19.1%
RVMD Sept. 30, 2025 10,000 $367,900 354.7%
GSK March 31, 2025 10,110 $341,920 33.6%
ANAB June 30, 2026 6,000 $332,760 -14.9%
RAPP June 30, 2026 10,000 $312,900 15.5%
WGS March 31, 2025 4,000 $307,440 -8.1%
MDGL March 31, 2026 500 $291,170 -0.9%
IOBT Sept. 30, 2025 192,670 $267,811 No longer tracked
THC March 31, 2025 2,027 $255,868 104.1%
ZYME June 30, 2026 10,000 $250,400 3.5%
LBRX June 30, 2026 10,000 $246,600 48.2%
ORKA June 30, 2026 5,000 $245,250 12.4%
JSPR June 30, 2026 276,312 $242,105 70.0%
ONC March 31, 2025 1,150 $212,417 38.2%
AXSM Sept. 30, 2025 2,000 $208,780 71.8%
ELV March 31, 2025 550 $202,895 -8.1%
DYN March 31, 2026 10,000 $195,600 45.6%
ADPT Sept. 30, 2025 10,000 $116,500 67.6%
DCTH March 31, 2026 10,000 $101,000 79.8%