Paradigm Biocapital Advisors LP
Portfolio value QoQ: +9.1% 13F does not disclose cash
Top 10 holdings weight75.21%
Top 25 holdings weight99.01%
Positions above 1%19
Effective number of positions10.5
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 23.12% Est. buys $1,183,069,073 · sells $1,691,186,654
Median holding: 2.5 quarters Tracked Q1 2025–Q2 2026 · 41.2% still held
New positions7
Increased12
Decreased7
Closed14
Portfolio value
$5.3B
Positions
28
As of
June 30, 2026 Data as of Q2 2026
Sector breakdown
Full portfolio 28 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| RVMD | $1,191,348,571 | 22.31% | 6,361,323 | $544,081,454 | Down ×1 | ||
| NUVL | $731,667,476 | 13.70% | 5,924,433 | $186,179,315 | Up ×2 | ||
| EWTX | $415,053,937 | 7.77% | 10,215,455 | $183,055,240 | Up ×5 | ||
| GMAB | $360,767,109 | 6.76% | 13,133,131 | $146,990,069 | Up ×3 | ||
| SYRE | $340,984,271 | 6.38% | 3,840,778 | $242,259,774 | Up ×2 | ||
| APGE | $209,233,581 | 3.92% | 1,576,385 | $95,751,968 | Up ×2 | ||
| ORKA | $204,094,539 | 3.82% | 2,144,526 | $90,283,039 | Down ×1 | ||
| TNGX | $198,736,169 | 3.72% | 6,357,523 | $114,853,684 | Up ×1 | ||
| BLTE | $189,844,565 | 3.55% | 1,232,877 | $12,103,404 | Up ×1 | ||
| ERAS | $174,956,000 | 3.28% | 9,550,000 | $6,802,082 | Down ×2 | ||
| TARS | $174,699,348 | 3.27% | 2,775,649 | $-5,035,755 | Up ×1 | ||
| ALNY | $144,494,400 | 2.71% | 480,000 | Up ×1 | |||
| INSM | $141,375,668 | 2.65% | 1,325,977 | $-63,758,210 | Up ×1 | ||
| MBX | $138,442,428 | 2.59% | 2,508,015 | Up ×1 | |||
| PCVX | $123,692,037 | 2.32% | 2,127,852 | $-154,830,355 | Down ×1 | ||
| VRDN | $123,515,986 | 2.31% | 6,723,788 | $61,923,639 | Up ×2 | ||
| OLMA | $108,468,906 | 2.03% | 8,670,576 | $-11,117,882 | Up ×5 | ||
| JBIO | $63,491,539 | 1.19% | 2,857,405 | Up ×1 | |||
| TYRA | $58,405,708 | 1.09% | 1,828,607 | $-20,300,447 | Down ×1 | ||
| ASMB | $42,696,995 | 0.80% | 1,553,748 | $24,236,280 | Up ×1 | ||
| EYPT | $41,332,677 | 0.77% | 2,890,397 | $826,664 | Down ×2 | ||
| ACHV | $32,335,620 | 0.61% | 4,951,856 | Up ×1 | |||
| VOR | $32,217,500 | 0.60% | 1,750,000 | $997,500 | |||
| MPLT | $24,580,936 | 0.46% | 685,852 | Up ×1 | |||
| Unknown issuer (CUSIP: 485925101) | $21,465,000 | 0.40% | 900,000 | Up ×1 | |||
| LXEO | $19,436,403 | 0.36% | 4,175,382 | $-16,060,526 | Down ×1 | ||
| EDIT | $18,100,665 | 0.34% | 5,586,625 | Up ×1 | |||
| IVA | $15,120,000 | 0.28% | 4,000,000 | $-7,080,000 | |||
| No matches | |||||||
Conviction holdings
Positions increased for 3+ consecutive quarters.
Share counts are as reported in 13F filings (not split-adjusted)
Biggest new bets
New positions opened this quarter, largest first.
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| RVMD | Trimmed | -294K | +$544.1M |
| SYRE | Bought more | +1.9M | +$242.3M |
| NUVL | Bought more | +600K | +$186.2M |
| EWTX | Bought more | +2.9M | +$183.1M |
| PCVX | Trimmed | -2.7M | -$154.8M |
| GMAB | Bought more | +5.2M | +$147.0M |
| TNGX | Bought more | +2.3M | +$114.9M |
| APGE | Bought more | +228K | +$95.8M |
| ORKA | Trimmed | -176K | +$90.3M |
| INSM | Bought more | +71K | -$63.8M |
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| ACLX | June 30, 2026 | 5,774,016 | $662,972,517 | No longer tracked |
| MRUS | Dec. 31, 2025 | 4,673,770 | $440,035,446 | No longer tracked |
| XBI | March 31, 2026 | 1,500,000 | $182,895,000 | 17.1% |
| CDTX | March 31, 2026 | 759,565 | $167,780,313 | No longer tracked |
| CNTA | June 30, 2026 | 3,574,048 | $141,961,187 | No longer tracked |
| TERN | June 30, 2026 | 2,216,499 | $116,853,827 | No longer tracked |
| AGIO | Dec. 31, 2025 | 2,873,555 | $115,344,498 | 35.9% |
| CRNX | March 31, 2026 | 2,210,774 | $102,911,530 | No longer tracked |
| CYTK | June 30, 2026 | 1,480,857 | $97,603,285 | -28.1% |
| ABVX | June 30, 2026 | 772,473 | $86,014,869 | -34.0% |
| ONC | Sept. 30, 2025 | 347,787 | $84,188,799 | 10.8% |
| MAZE | June 30, 2026 | 2,744,399 | $81,920,310 | 3.9% |
| JANX | Dec. 31, 2025 | 2,920,258 | $71,371,106 | 20.7% |
| SRRK | June 30, 2026 | 1,226,080 | $60,274,093 | -24.6% |
| MIRM | June 30, 2026 | 625,000 | $57,737,500 | -31.3% |
| BBIO | March 31, 2026 | 684,277 | $52,340,348 | -7.7% |
| ALKS | Dec. 31, 2025 | 1,719,334 | $51,580,020 | 55.9% |
| LENZ | Dec. 31, 2025 | 1,073,461 | $50,001,813 | -80.3% |
| PHVS | Dec. 31, 2025 | 1,835,494 | $45,795,575 | 13.2% |
| COGT | Dec. 31, 2025 | 3,156,398 | $45,325,875 | -12.1% |
| MLTX | Sept. 30, 2025 | 878,323 | $41,456,846 | 65.3% |
| OCUL | March 31, 2026 | 2,935,284 | $35,634,348 | -23.3% |
| ARGX | June 30, 2025 | 59,679 | $35,321,911 | 58.5% |
| CYTK | June 30, 2025 | 858,664 | $34,509,706 | 85.3% |
| INSM | June 30, 2025 | 451,359 | $34,434,178 | -7.2% |
| MANE | June 30, 2026 | 525,000 | $33,153,750 | 12.9% |
| MTSR | June 30, 2025 | 1,191,462 | $32,431,596 | No longer tracked |
| URGN | June 30, 2026 | 1,703,949 | $30,637,003 | -6.3% |
| GPCR | June 30, 2026 | 545,287 | $26,282,833 | -60.5% |
| TNGX | Dec. 31, 2025 | 3,086,184 | $25,923,946 | 163.4% |
| AMLX | Dec. 31, 2025 | 1,900,000 | $25,821,000 | 125.2% |
| DYN | Dec. 31, 2025 | 1,898,950 | $24,021,718 | -20.1% |
| ARQT | June 30, 2025 | 1,465,334 | $22,917,824 | 122.5% |
| ORIC | June 30, 2026 | 1,701,217 | $21,554,419 | 21.6% |
| YMAB | Sept. 30, 2025 | 4,236,346 | $19,105,920 | No longer tracked |
| IMTX | Sept. 30, 2025 | 3,144,157 | $16,915,565 | -14.2% |
| IRON | Dec. 31, 2025 | 247,716 | $16,369,073 | -6.2% |
| GPCR | Dec. 31, 2025 | 372,869 | $10,440,332 | -69.5% |
| CBIO | Sept. 30, 2025 | 642,721 | $10,373,517 | 7.8% |
| BBOT | June 30, 2026 | 868,213 | $7,770,506 | -65.1% |
| KLRS | June 30, 2026 | 700,000 | $4,039,000 | -54.1% |