Affinity Asset Advisors, LLC

CIK 1773195 · View on SEC EDGAR ↗

Portfolio value QoQ: +14.3% 13F does not disclose cash

Top 10 holdings weight39.41%

Top 25 holdings weight64.62%

Positions above 1%31

Effective number of positions41.6

Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)

Turnover Q2 2026: 24.36% Est. buys $505,306,164 · sells $574,861,844

Median holding: 2.0 quarters Tracked Q1 2025–Q2 2026 · 51.4% still held

New positions26

Increased33

Decreased30

Closed15

Put-notional exposure: 2.5% puts 13F reports option positions at underlying notional value — may include hedges, not necessarily bearish bets

Portfolio value $2.2B #1,481 of 9,337 by 13F value · top 15.9%

Positions 113

As of June 30, 2026 Data as of Q2 2026

Performance vs S&P 500

Tracked Q1 2025–Q2 2026 +146.2%

S&P 500 total return (same window) +37.0%

Excess return +109.2%

Annualized: +105.7% · S&P 500: +28.7%

Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.

Priceable coverage: 91.4% · Options excluded: 17.1%

Sector breakdown

Healthcare 91.6%

Other/Unmapped 8.4%

Full portfolio 113 positions

Search positions by ticker or company name

				Type		Streak
ROIV Roivant Sciences Ltd. - Common Shares	$132,712,500	6.00%	3,750,000		$55,152,500	Up ×5
APGE Apogee Therapeutics, Inc. - Common Stock	$131,004,510	5.92%	987,000		$22,852,289	Down ×1
SYRE Spyre Therapeutics, Inc. - Common Stock	$113,561,517	5.13%	1,279,134		$49,041,998
XENE Xenon Pharmaceuticals Inc. - Common Shares	$96,274,200	4.35%	1,595,000		$-1,127,050	Down ×1
ERAS Erasca, Inc. - Common Stock	$96,180,000	4.35%	5,250,000		$9,617,000	Down ×1
INSM Insmed Incorporated - Common Stock	$69,303,000	3.13%	650,000		$-9,186,600	Up ×2
PRAX Praxis Precision Medicines, Inc. - Common Stock	$61,936,150	2.80%	185,000		$7,163,850	Up ×1
ALKS Alkermes plc - Ordinary Shares	$58,944,375	2.66%	1,125,000		$11,208,375	Down ×1
ORKA Oruka Therapeutics, Inc. - Common Stock	$56,150,300	2.54%	590,000		$31,641,339	Up ×1
ANAB AnaptysBio, Inc. - Common Stock	$55,762,358	2.52%	826,109		$3,629,958	Down ×1
AVTX Avalo Therapeutics, Inc. - Common Stock	$53,592,000	2.42%	2,900,000		$33,573,259	Up ×4
CYTK Cytokinetics, Incorporated - Common Stock	$46,854,500	2.12%	550,000		$685,665	Down ×2
RVMD Revolution Medicines, Inc. - Common Stock	$46,820,000	2.12%	250,000		$37,095,000	Up ×1
ABVX Abivax SA - American Depositary Shares	$43,975,800	1.99%	330,000		$-1,120,950	Down ×2
Unknown issuer (CUSIP: 337185102)	$40,884,081	1.85%	2,032,012			Up ×1
DNTH Dianthus Therapeutics, Inc. - Common Stock	$38,992,000	1.76%	400,000		$9,620,000	Up ×2
STRO Sutro Biopharma, Inc. - Common Stock	$38,926,568	1.76%	1,172,487		$12,284,850	Up ×2
MRNA Moderna, Inc. - Common Stock	$35,015,000	1.58%	500,000	Put option		Up ×1
NUVL Nuvalent, Inc. - Class A Common Stock	$33,962,500	1.54%	275,000		$3,227,500	Down ×5
TRVI Trevi Therapeutics, Inc. - Common Stock	$33,573,208	1.52%	1,800,172		$9,711,156	Down ×3
MRNA Moderna, Inc. - Common Stock	$33,264,250	1.50%	475,000	Call option	$-7,375,750	Down ×1
ARKG ARK ETF Trust	$31,545,000	1.43%	750,000	Call option		Up ×1
OVID Ovid Therapeutics Inc. - Common Stock	$27,288,872	1.23%	10,144,562		$3,676,246	Down ×1
LXEO Lexeo Therapeutics, Inc. - Common Stock	$27,034,429	1.22%	5,807,611		$-1,953,782	Up ×2
CLDX Celldex Therapeutics, Inc. - Common Stock	$26,047,000	1.18%	700,000		$10,187,000	Up ×3
BLTE Belite Bio, Inc - American Depositary Shares	$25,407,525	1.15%	165,000		$15,043,925	Up ×2
ELVN Enliven Therapeutics, Inc. - Common Stock	$25,375,000	1.15%	500,000		$2,368,363	Down ×1
FBRX Forte Biosciences, Inc. - Common Stock	$24,339,559	1.10%	1,145,391		$-1,868,392	Up ×2
LLY Eli Lilly and Company Common Stock	$23,988,600	1.08%	20,000	Call option		Up ×1
NRIX Nurix Therapeutics, Inc. - Common stock	$23,474,461	1.06%	967,620		$8,476,351
ANRO Alto Neuroscience, Inc. Common Stock	$22,431,500	1.01%	850,000		$11,191,500	Up ×1
MDGL Madrigal Pharmaceuticals, Inc. - Common Stock	$21,478,000	0.97%	40,000		$-7,312,850	Down ×1
PTGX Protagonist Therapeutics, Inc. - Common Stock	$21,099,083	0.95%	172,125		$2,957,108
MLYS Mineralys Therapeutics, Inc. - Common Stock	$20,235,000	0.91%	750,000		$-82,500
RLAY Relay Therapeutics, Inc. - Common Stock	$19,645,500	0.89%	1,050,000		$15,665,500	Up ×1
SGMT Sagimet Biosciences Inc. - Series A Common Stock	$19,308,489	0.87%	2,497,864		$14,773,084	Up ×1
JBIO Jade Biosciences, Inc. - Common Stock	$18,672,577	0.84%	840,350		$9,681,195	Up ×1
COGT Cogent Biosciences, Inc. - Common Stock	$17,415,000	0.79%	450,000		$-11,452,500	Down ×1
TVTX Travere Therapeutics, Inc. - Common Stock	$17,043,000	0.77%	300,000		$8,130,000
CGEM Cullinan Therapeutics, Inc. - Common Stock	$15,947,590	0.72%	875,760		$4,845,885	Up ×1
SVRA Savara, Inc. - Common Stock	$15,474,862	0.70%	2,512,153		$1,758,507
IDYA IDEAYA Biosciences, Inc. - Common Stock	$14,908,000	0.67%	400,000			Up ×1
CATX CUSIP: 46489V302	$14,371,725	0.65%	4,214,582		$1,175,418	Up ×2
Unknown issuer (CUSIP: 67613T104)	$14,338,334	0.65%	766,346			Up ×1
Unknown issuer (CUSIP: 19240QAA0)	$13,653,740	0.62%	11,000,000		$5,068,240	Up ×2
OMER Omeros Corporation - Common Stock	$13,421,463	0.61%	1,411,300	Put option
HLXC Helix Acquisition Corp. III - Class A Ordinary Shares	$13,300,000	0.60%	1,250,000		$600,000
EQ Equillium, Inc. - Common Stock	$13,120,000	0.59%	4,100,000		$10,667,380	Up ×1
ALKS Alkermes plc - Ordinary Shares	$13,098,750	0.59%	250,000	Call option		Up ×1
ESTA Establishment Labs Holdings Inc. - Common Shares	$12,700,996	0.57%	148,013		$7,022,996	Up ×1
CLYM Climb Bio, Inc. - Common Stock	$12,674,880	0.57%	972,000		$7,879,880	Up ×1
TEVA Teva Pharmaceutical Industries Limited American Depositary Shares	$12,671,120	0.57%	374,000		$-29,496,880	Down ×1
MANE Veradermics, Incorporated Common Stock	$12,294,000	0.56%	100,000		$7,873,500	Up ×1
ARWR Arrowhead Pharmaceuticals, Inc. - Common Stock	$12,226,500	0.55%	150,000		$-313,500	Down ×1
Unknown issuer (CUSIP: 682143AK8)	$12,182,372	0.55%	6,525,000		$-1,036,854
TSHA Taysha Gene Therapies, Inc. - Common Stock	$11,917,500	0.54%	1,750,000		$7,447,500	Up ×1
GLTO Galecto, Inc. - Common Stock	$11,054,250	0.50%	425,000		$-600,750	Down ×1
EPRX Eupraxia Pharmaceuticals Inc. - Common Stock	$10,906,500	0.49%	1,650,000		$-597,896	Up ×2
VERA Vera Therapeutics, Inc. - Class A Common Stock	$10,727,500	0.48%	250,000		$670,000
PRQR ProQR Therapeutics N.V. - Ordinary Shares	$10,311,721	0.47%	5,543,936		$6,335,791	Up ×1
NAMS NewAmsterdam Pharma Company N.V. - Ordinary Shares	$9,319,750	0.42%	275,000		$517,000
KRRO Korro Bio, Inc. - Common Stock	$9,316,995	0.42%	706,904		$1,314,842
QURE uniQure N.V. - Ordinary Shares	$9,212,000	0.42%	200,000	Call option	$4,307,000	Down ×2
AVR Anteris Technologies Global Corp. - Common Stock	$8,987,110	0.41%	912,397		$3,923,307
ZURA Zura Bio Limited - Class A Ordinary shares	$8,639,388	0.39%	1,464,303		$-6,618,215	Down ×1
QURE uniQure N.V. - Ordinary Shares	$8,060,500	0.36%	175,000
Unknown issuer (CUSIP: K08588103)	$8,001,600	0.36%	30,000			Up ×1
IBIO iBio, Inc. - Common Stock	$7,013,792	0.32%	4,007,881		$1,110,112	Up ×2
Unknown issuer (CUSIP: 370920100)	$6,748,000	0.30%	400,000		$2,373,000	Up ×1
EVMN Evommune, Inc. Common Stock	$6,646,329	0.30%	500,100	Put option		Up ×1
TYRA Tyra Biosciences, Inc. - Common Stock	$6,388,383	0.29%	200,012		$-3,474,327	Down ×1
SLGL Sol-Gel Technologies Ltd. - Ordinary Shares	$6,294,486	0.28%	84,900		$3,521,786	Up ×1
SABS SAB Biotherapeutics, Inc. - Common Stock	$5,947,500	0.27%	1,525,000		$3,745,250	Up ×1
MGNX MacroGenics, Inc. - Common Stock	$5,620,720	0.25%	1,216,606		$4,175,720	Up ×2
CRSP CRISPR Therapeutics AG - Common Shares	$5,454,000	0.25%	100,000		$-1,681,500	Down ×1
NAMSW NewAmsterdam Pharma Company N.V. - Warrant	$5,343,450	0.24%	245,000		$433,650
ASMB Assembly Biosciences, Inc. - Common Stock	$5,221,200	0.24%	190,000			Up ×1
RZLT Rezolute, Inc. - Common Stock (NV)	$5,200,000	0.24%	1,000,000		$479,695	Down ×2
DTIL Precision BioSciences, Inc. - Common Stock	$5,082,087	0.23%	646,576		$1,793,384	Up ×1
Unknown issuer (CUSIP: 423494103)	$5,069,842	0.23%	138,030			Up ×1
VRDN Viridian Therapeutics, Inc. - Common Stock	$4,592,500	0.21%	250,000		$-297,500
AVBP ArriVent BioPharma, Inc. - Common Stock	$4,342,500	0.20%	125,000		$305,250	Down ×1
VRCA Verrica Pharmaceuticals Inc. - Common Stock	$4,328,909	0.20%	707,338		$587,091
CMPS COMPASS Pathways Plc - American Depository Shares	$4,261,739	0.19%	301,183		$-1,868,172	Down ×1
MBX MBX Biosciences, Inc. - Common Stock	$4,140,000	0.19%	75,000		$-337,500	Down ×2
Unknown issuer (CUSIP: G75226103)	$3,959,000	0.18%	370,000			Up ×1
IMVT Immunovant, Inc. - Common Stock	$3,853,000	0.17%	100,000		$1,369,000
Unknown issuer (CUSIP: G0375M101)	$3,810,000	0.17%	375,000			Up ×1
BHVN Biohaven Ltd. Common Shares	$3,720,000	0.17%	250,000			Up ×1
SNSE Sensei Biotherapeutics, Inc. - Common Stock	$3,610,100	0.16%	144,404			Up ×1
KPTI Karyopharm Therapeutics Inc. - Common Stock	$3,053,125	0.14%	312,500		$268,125	Down ×2
ALEC Alector, Inc. - Common Stock	$3,035,100	0.14%	1,510,000		$1,960,100	Up ×1
SGP SpyGlass Pharma, Inc. - Common Stock	$2,929,104	0.13%	131,586		$-3,548,396	Down ×1
CRNX Crinetics Pharmaceuticals, Inc. - Common Stock	$2,806,500	0.13%	75,000		$82,500
OACCU Oaktree Acquisition Corp. III Life Sciences - Unit	$2,750,000	0.12%	250,000		$87,500
Unknown issuer (CUSIP: 15102KAB6)	$2,282,800	0.10%	2,000,000			Up ×1
Unknown issuer (CUSIP: G50765109)	$2,272,000	0.10%	200,000			Up ×1
NMRA Neumora Therapeutics, Inc. - Common Stock	$1,820,107	0.08%	1,070,651			Up ×1
AMLX Amylyx Pharmaceuticals, Inc. - Common Stock	$1,778,022	0.08%	98,999			Up ×1
ANL Adlai Nortye Ltd. - American Depositary Shares	$1,769,241	0.08%	153,847		$629,185	Down ×1
No matches

Conviction holdings

Positions increased for 3+ consecutive quarters.

Share counts are as reported in 13F filings (not split-adjusted)

Security	Value	% of portfolio	Streak
ROIV	$132,712,500	6.00%	up ×5
AVTX	$53,592,000	2.42%	up ×4
CLDX	$26,047,000	1.18%	up ×3

Biggest new bets

New positions opened this quarter, largest first.

Security	Value	Shares	% of portfolio
Unknown issuer (CUSIP: 337185102)	$40,884,081	2,032,012	1.85%
MRNA	$35,015,000	500,000	1.58%
ARKG	$31,545,000	750,000	1.43%
LLY	$23,988,600	20,000	1.08%
IDYA	$14,908,000	400,000	0.67%
Unknown issuer (CUSIP: 67613T104)	$14,338,334	766,346	0.65%
OMER	$13,421,463	1,411,300	0.61%
ALKS	$13,098,750	250,000	0.59%
QURE	$8,060,500	175,000	0.36%
Unknown issuer (CUSIP: K08588103)	$8,001,600	30,000	0.36%
EVMN	$6,646,329	500,100	0.30%
ASMB	$5,221,200	190,000	0.24%
Unknown issuer (CUSIP: 423494103)	$5,069,842	138,030	0.23%
Unknown issuer (CUSIP: G75226103)	$3,959,000	370,000	0.18%
Unknown issuer (CUSIP: G0375M101)	$3,810,000	375,000	0.17%

Top movers (QoQ)

Security	Action	Shares Δ	Value Δ
ROIV	Bought more	+950K	+$55.2M
SYRE	Price move only	+0	+$49.0M
RVMD	Bought more	+150K	+$37.1M
AVTX	Bought more	+1.6M	+$33.6M
ORKA	Bought more	+90K	+$31.6M
TEVA	Trimmed	-1.0M	-$29.5M
APGE	Trimmed	-298K	+$22.9M
RLAY	Bought more	+650K	+$15.7M
BLTE	Bought more	+100K	+$15.0M
SGMT	Bought more	+1.6M	+$14.8M

Exited positions

Includes corporate events (mergers, delistings) — not all exits are sells

Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.

Security	Quarter	Shares before	Value before	Price since exit
SPY	June 30, 2025	430,000	$240,537,700	No longer tracked
XBI	March 31, 2026	1,500,000	$182,895,000	20.9%
SPY	June 30, 2026	200,000	$130,068,000	No longer tracked
IBB	March 31, 2026	400,000	$67,508,000	21.6%
VRNA	Dec. 31, 2025	625,000	$66,693,750	No longer tracked
IWM	June 30, 2025	300,000	$59,847,000	30.7%
VTYX	March 31, 2026	6,484,558	$58,555,559	No longer tracked
SPY	Dec. 31, 2025	84,490	$56,285,548	No longer tracked
CNTA	June 30, 2026	1,400,000	$55,608,000	No longer tracked
AMGN	March 31, 2026	145,000	$47,459,950	14.5%
ACLX	June 30, 2026	362,764	$41,652,562	No longer tracked
XBI	June 30, 2025	500,000	$40,550,000	86.2%
XLV	March 31, 2026	250,000	$38,700,000	13.3%
BPMC	Sept. 30, 2025	250,000	$32,045,000	No longer tracked
TERN	June 30, 2026	562,631	$29,661,906	No longer tracked
MRUS	Dec. 31, 2025	285,769	$26,905,151	No longer tracked
PTGX	Sept. 30, 2025	440,000	$24,318,800	110.8%
ASND	June 30, 2026	95,000	$21,729,350	-14.6%
EXEL	Dec. 31, 2025	500,000	$20,650,000	33.2%
BMY	June 30, 2026	300,000	$18,195,000	6.1%
ALNY	June 30, 2025	55,000	$14,851,100	-32.6%
SLNO	Dec. 31, 2025	200,000	$13,520,000	No longer tracked
AMGN	Sept. 30, 2025	40,000	$11,168,400	42.8%
BBIO	June 30, 2026	150,000	$11,139,000	-9.7%
WVE	June 30, 2026	1,401,727	$10,162,521	-34.9%
CRSP	Sept. 30, 2025	200,000	$9,728,000	-14.5%
IBRX	June 30, 2026	1,250,000	$9,587,500	17.5%
TNGX	March 31, 2026	1,000,000	$8,860,000	11.1%
ELVN	Sept. 30, 2025	400,000	$8,024,000	129.5%
CORT	June 30, 2025	70,000	$7,995,400	58.4%
TARS	Dec. 31, 2025	125,000	$7,428,750	-10.8%
IMVT	June 30, 2025	430,000	$7,348,700	110.1%
RCUS	March 31, 2026	300,000	$7,149,000	13.1%
INZY	Sept. 30, 2025	1,749,359	$6,997,436	No longer tracked
AKBA	Dec. 31, 2025	2,450,000	$6,688,500	-46.3%
MNPR	Dec. 31, 2025	79,483	$6,491,377	19.4%
NVO	June 30, 2026	175,000	$6,431,250	-22.2%
SMMT	March 31, 2026	350,000	$6,121,500	-11.6%
NBIX	June 30, 2025	50,000	$5,530,000	13.9%
AVDL	March 31, 2026	250,000	$5,387,500	No longer tracked
AXSM	Sept. 30, 2025	50,000	$5,219,500	47.6%
NTLA	Dec. 31, 2025	300,000	$5,181,000	36.4%
OLMA	Dec. 31, 2025	500,000	$4,895,000	-67.1%
OMER	Dec. 31, 2025	1,133,900	$4,648,990	8.3%
PCVX	Dec. 31, 2025	125,000	$4,502,500	22.4%
EWTX	June 30, 2025	200,000	$4,400,000	215.8%
ENGN	June 30, 2026	610,370	$4,156,620	12.1%
CGON	June 30, 2026	60,000	$4,060,800	-5.2%
INSP	Dec. 31, 2025	50,000	$3,710,000	-24.1%
SLNO	June 30, 2025	50,000	$3,572,500	No longer tracked
CELC	June 30, 2026	30,000	$3,424,200	-31.1%
JAZZ	Dec. 31, 2025	25,000	$3,295,000	38.6%
IBRX	June 30, 2025	1,025,000	$3,085,250	289.6%
MRSN	March 31, 2026	100,000	$2,893,000	No longer tracked
AUTL	Dec. 31, 2025	1,750,000	$2,852,500	-10.6%
OCUL	Dec. 31, 2025	239,000	$2,793,910	-42.7%
CMPX	June 30, 2025	1,461,507	$2,776,863	-67.1%
MAZE	June 30, 2025	250,000	$2,752,500	115.4%
KYMR	June 30, 2025	100,000	$2,737,000	146.1%
ABUS	March 31, 2026	521,900	$2,510,339	-1.1%
RAPP	Sept. 30, 2025	199,643	$2,269,941	8.3%
ATXS	Dec. 31, 2025	300,000	$2,184,000	No longer tracked
UTHR	Dec. 31, 2025	5,000	$2,096,050	11.2%
CORT	June 30, 2026	50,000	$2,015,500	33.7%
THRD	Sept. 30, 2025	370,000	$2,009,100	No longer tracked
AVTE	June 30, 2025	800,000	$2,008,000	No longer tracked
GERN	March 31, 2026	1,500,000	$1,980,000	-19.5%
CAPR	Sept. 30, 2025	175,000	$1,737,750	24.1%
RARE	March 31, 2026	75,000	$1,725,000	-27.4%
KZR	June 30, 2026	229,076	$1,699,744	No longer tracked
NVAX	Sept. 30, 2025	250,000	$1,575,000	20.6%
TRML	June 30, 2025	100,000	$1,521,000	No longer tracked
ATYR	Dec. 31, 2025	2,100,000	$1,514,940	-63.3%
MIST	Dec. 31, 2025	666,666	$1,333,332	-59.9%
NKTX	Sept. 30, 2025	800,000	$1,328,000	24.4%
MBX	June 30, 2025	175,000	$1,291,500	412.8%
ETNB	June 30, 2025	175,000	$1,272,250	No longer tracked
MIRM	Sept. 30, 2025	24,692	$1,256,576	13.1%
MGTX	June 30, 2025	150,000	$1,017,000	65.5%
OKUR	Sept. 30, 2025	347,990	$831,696	-6.9%
INMB	Sept. 30, 2025	354,000	$817,740	-6.8%
ALT	Sept. 30, 2025	200,000	$774,000	-27.5%
PCSC	March 31, 2026	50,000	$651,500	No longer tracked
VKTX	June 30, 2025	25,000	$603,750	13.0%
GALT	Sept. 30, 2025	250,000	$527,500	-8.0%
CNTX	Dec. 31, 2025	402,653	$390,090	-78.9%
BDTX	June 30, 2025	250,000	$387,500	-23.8%
RPTX	Dec. 31, 2025	200,000	$352,000	No longer tracked
CBIO	Dec. 31, 2025	17,998	$213,996	20.7%
RADX	Sept. 30, 2025	35,635	$166,059	-74.3%
ALLK	June 30, 2025	250,000	$56,900	No longer tracked
SPRY	Dec. 31, 2025	2,500	$25,125	-65.1%
IMTXW	Sept. 30, 2025	187,204	$112	No longer tracked