ORBIMED ADVISORS LLC

CIK 1055951 · View on SEC EDGAR ↗

Portfolio value
$5.4B
#761 of 9,443 by 13F value · top 8.1%
Positions
129
As of
June 30, 2026

Portfolio value QoQ: +8.3% 13F does not disclose cash

Top 10 holdings weight
42.10%
Top 25 holdings weight
62.79%
Positions above 1%
31
Effective number of positions
31.9

Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)

Turnover Q2 2026: 20.87% Est. buys $1,083,352,679 · sells $1,363,417,556

Median holding: 3.0 quarters Tracked Q4 2024–Q2 2026 · 51.0% still held

New positions
42
Increased
33
Decreased
26
Closed
24

Put-notional exposure: 0.9% puts 13F reports option positions at underlying notional value — may include hedges, not necessarily bearish bets

On this page

Performance vs S&P 500

Tracked Q4 2024–Q2 2026
+55.8%
S&P 500 total return (same window)
+28.1%
Excess return
+27.8%

Annualized: +34.5% · S&P 500: +18.0%

Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.

Priceable coverage: 97.9% · Options excluded: 2.4%

Sector breakdown

Healthcare
95.2%
Other/Unmapped
4.8%

Full portfolio 129 positions

Type Streak 8Q trend
EWTX Edgewise Therapeutics, Inc. - Common Stock $630,516,330 11.68% 15,518,492 $141,683,832
ELVN Enliven Therapeutics, Inc. - Common Stock $343,914,074 6.37% 6,776,632 $31,900,184 Down ×1
LLY Eli Lilly and Company Common Stock $309,332,997 5.73% 257,900 $91,531,461 Up ×1
MBX MBX Biosciences, Inc. - Common Stock $189,266,227 3.51% 3,428,736 $80,675,300 Down ×3
SVA Sinovac Biotech, Ltd. - Ordinary Shares (Antigua/Barbudo) $184,466,170 3.42% 2,718,735 $0
AZN AstraZeneca PLC - American Depositary Shares $171,079,502 3.17% 915,700 $38,902,658 Up ×1
GPCR Structure Therapeutics Inc. - American Depositary Shares $118,578,498 2.20% 2,209,400 $47,464,073 Up ×3
SION Sionna Therapeutics, Inc. - Common Stock $112,433,029 2.08% 2,555,877 $-29,112,814 Down ×3
CRVS Corvus Pharmaceuticals, Inc. - Common Stock $107,045,190 1.98% 7,165,006 $2,221,152
AVBP ArriVent BioPharma, Inc. - Common Stock $105,169,375 1.95% 3,027,328 $35,328,918
GH Guardant Health, Inc. - Common Stock $87,572,511 1.62% 583,700 $47,373,087 Up ×1
ARGX argenx SE - American Depositary Shares $86,171,278 1.60% 92,880 $-13,799,947 Down ×4
MRK Merck & Company, Inc. Common Stock (new) $85,246,900 1.58% 663,400 $5,446,514
QURE uniQure N.V. - Ordinary Shares $83,252,805 1.54% 1,807,486 $48,326,769 Down ×1
PRAX Praxis Precision Medicines, Inc. - Common Stock $77,035,179 1.43% 230,100 $21,457,404 Up ×2
EW Edwards Lifesciences Corporation Common Stock $75,525,054 1.40% 834,900 $-23,021,394 Down ×2
PRLD Prelude Therapeutics Incorporated - Common Stock $73,151,963 1.36% 13,724,571 $35,842,307 Up ×1
ABVX Abivax SA - American Depositary Shares $72,829,522 1.35% 546,522 $20,973,827 Up ×2
DYN Dyne Therapeutics, Inc. - Common Stock $71,864,542 1.33% 3,235,684 $18,963,305 Up ×2
NTRA Natera, Inc. - Common Stock $71,119,900 1.32% 262,000 $18,722,520
CGON CG Oncology, Inc. - Common stock $69,117,440 1.28% 972,800 $4,938,729 Up ×1
UNH UnitedHealth Group Incorporated Common Stock (DE) $66,957,993 1.24% 161,100
SPRY ARS Pharmaceuticals, Inc. - Common Stock $66,390,965 1.23% 8,288,510 $-165,770
Unknown issuer (CUSIP: K08588103) $65,201,304 1.21% 244,456 Up ×1
HUM Humana Inc. Common Stock $65,183,802 1.21% 164,100 Up ×1
COGT Cogent Biosciences, Inc. - Common Stock $65,066,310 1.21% 1,681,300 $52,668,681 Up ×1
BSX Boston Scientific Corporation Common Stock $63,302,976 1.17% 1,483,200 $-86,173,799 Down ×4
ISRG Intuitive Surgical, Inc. - Common Stock $62,793,672 1.16% 157,900 $-33,414,941 Down ×4
MLYS Mineralys Therapeutics, Inc. - Common Stock $56,935,894 1.05% 2,110,300 $1,322,833 Up ×2
Unknown issuer (CUSIP: 67613T104) $56,152,415 1.04% 3,001,198 Up ×1
XENE Xenon Pharmaceuticals Inc. - Common Shares $53,869,550 1.00% 892,471 $-7,767,764 Down ×1
ARQT Arcutis Biotherapeutics, Inc. - Common stock $53,541,240 0.99% 2,042,000 Up ×1
BMY Bristol-Myers Squibb Company Common Stock $53,298,500 0.99% 925,000 $-2,802,750
QTTB Q32 Bio Inc. - Common Stock $52,590,554 0.97% 4,127,987 $38,126,377 Up ×1
SYK Stryker Corporation Common Stock $50,091,044 0.93% 159,100 $-9,876,631 Down ×3
CAI Caris Life Sciences, Inc. - Common Stock $50,017,372 0.93% 2,806,811 $-168,409
XBI XBI $47,475,000 0.88% 300,000 Put option Up ×1
TMO Thermo Fisher Scientific Inc Common Stock $45,473,352 0.84% 90,700 $22,617,207 Up ×1
PVLA Palvella Therapeutics, Inc. - Common Stock $44,678,455 0.83% 292,360 $27,900,565 Up ×1
ELV Elevance Health, Inc. Common Stock $44,357,931 0.82% 114,700 $10,779,506
STTK Shattuck Labs, Inc. - Common Stock $43,764,521 0.81% 6,306,127 $3,216,124
UPB Upstream Bio, Inc. - Common Stock $39,399,636 0.73% 5,693,589 $-11,842,665
CRNX Crinetics Pharmaceuticals, Inc. - Common Stock $37,382,580 0.69% 999,000 $1,098,900
RYTM Rhythm Pharmaceuticals, Inc. - Common Stock $35,851,587 0.66% 322,900 $8,534,310 Up ×3
SNDX Syndax Pharmaceuticals, Inc. - Common Stock $33,708,120 0.62% 1,542,000 $11,228,792 Up ×1
FBRX Forte Biosciences, Inc. - Common Stock $33,526,231 0.62% 1,577,705 $2,525,096 Up ×1
CMPX Compass Therapeutics, Inc. - Common Stock $33,331,787 0.62% 15,219,994 $-47,181,981
NKTR Nektar Therapeutics - Common Stock $32,485,804 0.60% 465,346 $12,699,554 Up ×1
KRYS Krystal Biotech, Inc. - Common Stock $30,922,944 0.57% 83,200 $13,073,032 Up ×1
Unknown issuer (CUSIP: 000000000) $30,275,391 0.56% 5,680,186 $27,621,826 Up ×1
AXSM Axsome Therapeutics, Inc. - Common Stock $28,779,567 0.53% 117,578 $-7,377,360 Down ×3
KNSA Kiniksa Pharmaceuticals International, plc - Class A Ordinary Shares $26,897,370 0.50% 420,600 $18,201,528 Up ×1
TRVI Trevi Therapeutics, Inc. - Common Stock $26,674,964 0.49% 1,430,293 $-2,606,028 Down ×3
ABVX Abivax SA - American Depositary Shares $26,652,000 0.49% 200,000 Call option Up ×1
IRON Disc Medicine, Inc. - Common Stock $26,150,110 0.48% 357,535 $-42,109,037 Down ×1
WST West Pharmaceutical Services, Inc. Common Stock $25,345,400 0.47% 70,600 Up ×1
RLMD Relmada Therapeutics, Inc. - Common Stock $25,127,869 0.47% 3,631,195 $-7,694,544 Down ×1
URGN UroGen Pharma Ltd. - Ordinary Shares $24,883,682 0.46% 676,187 $9,142,426 Down ×1
STRO Sutro Biopharma, Inc. - Common Stock $24,698,941 0.46% 743,944 $4,742,444 Down ×1
SVRA Savara, Inc. - Common Stock $24,392,984 0.45% 3,959,900 $20,925,884 Up ×1
NPCE Neuropace, Inc. - Common Stock $23,916,436 0.44% 1,505,125 $-3,652,894 Down ×3
AURA Aura Biosciences, Inc. - Common Stock $23,666,664 0.44% 3,333,333 Up ×1
ORIC Oric Pharmaceuticals, Inc. - Common Stock $21,822,450 0.40% 2,015,000 $-12,309,630 Down ×2
HELP Cybin Inc. - Common Stock $21,623,954 0.40% 3,271,400 $3,226,308 Down ×2
BCRX BioCryst Pharmaceuticals, Inc. - Common Stock $18,520,000 0.34% 1,852,000 $4,952,096 Up ×1
BIOA BioAge Labs, Inc. - Common Stock $18,435,270 0.34% 752,153 $5,985,696 Up ×1
PTGX Protagonist Therapeutics, Inc. - Common Stock $18,387,000 0.34% 150,000 Call option Up ×1
LXEO Lexeo Therapeutics, Inc. - Common Stock $18,377,242 0.34% 3,947,850 $-2,300,821 Up ×2
WHWK Whitehawk Therapeutics, Inc. - Common Stock $18,019,076 0.33% 3,934,296 $3,646,376 Down ×1
DFTX Definium Therapeutics, Inc. - Common Shares $17,188,416 0.32% 365,400 $1,992,816 Down ×1
SYRE Spyre Therapeutics, Inc. - Common Stock $16,525,953 0.31% 186,145 Up ×1
CRBP Corbus Pharmaceuticals Holdings, Inc. - Common Stock $16,295,752 0.30% 1,737,287 $-17,373
VERA Vera Therapeutics, Inc. - Class A Common Stock $15,859,364 0.29% 369,596 $990,517
ALMS Alumis Inc. - Common Stock $15,425,307 0.29% 548,163 $3,349,276
EYPT EyePoint, Inc. - Common Stock $15,288,802 0.28% 1,069,147 $1,507,497
WAT Waters Corporation Common Stock $15,114,112 0.28% 40,300 Up ×1
MNPR Monopar Therapeutics Inc. - Common Stock $14,575,796 0.27% 157,423 Up ×1
TVTX Travere Therapeutics, Inc. - Common Stock $14,372,930 0.27% 253,000 Up ×1
TSHA Taysha Gene Therapies, Inc. - Common Stock $13,620,000 0.25% 2,000,000 Up ×1
BIIB Biogen Inc. - Common Stock $13,309,296 0.25% 61,600 $2,016,168
RVMD Revolution Medicines, Inc. - Common Stock $13,203,240 0.24% 70,500 $8,146,240 Up ×2
DNTH Dianthus Therapeutics, Inc. - Common Stock $11,210,200 0.21% 115,000 Up ×1
SPRB Spruce Biosciences, Inc. - Common Stock $10,800,000 0.20% 200,000 Up ×1
LFST LifeStance Health Group, Inc. - Common Stock $10,146,654 0.19% 947,400 $6,961,654 Up ×1
RVMD Revolution Medicines, Inc. - Common Stock $9,364,000 0.17% 50,000 Call option Up ×1
ERAS Erasca, Inc. - Common Stock $9,084,888 0.17% 495,900 Up ×1
TARA Protara Therapeutics, Inc. - Common Stock $8,480,400 0.16% 2,220,000 Up ×1
KROS Keros Therapeutics, Inc. - common stock $8,122,959 0.15% 759,155 $-258,112
JANX Janux Therapeutics, Inc. - Common Stock $8,059,392 0.15% 524,700 $-5,612,648 Down ×2
TECX Tectonic Therapeutic, Inc. - Common Stock $7,789,375 0.14% 226,600 $785,169
ACET Adicet Bio, Inc. - Common Stock $7,298,960 0.14% 844,787 $298,661 Down ×1
PHVS Pharvaris N.V. - Ordinary Shares $7,102,732 0.13% 205,400 $1,300,182
ANRO Alto Neuroscience, Inc. Common Stock $6,804,714 0.13% 257,852 $3,039,314 Up ×2
ZNTL Zentalis Pharmaceuticals, Inc. - common stock $6,744,294 0.12% 1,390,576 Up ×1
DRUG Bright Minds Biosciences Inc. - common stock $6,528,600 0.12% 93,000 $3,609,800 Up ×1
PVLA Palvella Therapeutics, Inc. - Common Stock $6,112,800 0.11% 40,000 Call option $-119,700 Down ×1
ALXO ALX Oncology Holdings Inc. - Common Stock $5,933,150 0.11% 2,866,256 $186,307
Unknown issuer (CUSIP: 89422GAB3) $5,894,350 0.11% 5,000,000 Up ×1
Unknown issuer (CUSIP: 98422T209) $5,674,234 0.11% 592,300 Up ×1
BCAX Bicara Therapeutics Inc. - Common Stock $5,673,759 0.11% 191,100 $-7,598,838 Down ×1

Conviction holdings

Positions increased for 3+ consecutive quarters.

Share counts are as reported in 13F filings (not split-adjusted)

Security Value % of portfolio Streak
GPCR $118,578,498 2.20% up ×3
RYTM $35,851,587 0.66% up ×3

Biggest new bets

New positions opened this quarter, largest first.

Security Value Shares % of portfolio
UNH $66,957,993 161,100 1.24%
Unknown issuer (CUSIP: K08588103) $65,201,304 244,456 1.21%
HUM $65,183,802 164,100 1.21%
Unknown issuer (CUSIP: 67613T104) $56,152,415 3,001,198 1.04%
ARQT $53,541,240 2,042,000 0.99%
XBI $47,475,000 300,000 0.88%
ABVX $26,652,000 200,000 0.49%
WST $25,345,400 70,600 0.47%
AURA $23,666,664 3,333,333 0.44%
PTGX $18,387,000 150,000 0.34%
SYRE $16,525,953 186,145 0.31%
WAT $15,114,112 40,300 0.28%
MNPR $14,575,796 157,423 0.27%
TVTX $14,372,930 253,000 0.27%
TSHA $13,620,000 2,000,000 0.25%

Top movers (QoQ)

Security Action Shares Δ Value Δ
EWTX Price move only +0 +$141.7M
LLY Bought more +21K +$91.5M
BSX Trimmed -899K -$86.2M
MBX Trimmed -209K +$80.7M
QURE Trimmed -329K +$48.3M
GPCR Bought more +734K +$47.5M
GH Bought more +148K +$47.4M
CMPX Price move only +0 -$47.2M
IRON Trimmed -710K -$42.1M
AZN Bought more +246K +$38.9M

1 position hidden (data completeness check)

Exited positions

Includes corporate events (mergers, delistings) — not all exits are sells

Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.

SecurityQuarter Shares before Value before Price since exit
MDXH June 30, 2026 124,306,000 $285,903,800 91.6%
RCEL June 30, 2026 41,510,995 $156,458,309 132.4%
MYGN June 30, 2026 125,000,000 $122,875,000 -46.8%
UNH Sept. 30, 2025 386,300 $120,514,011 14.4%
SRPT March 31, 2025 963,400 $117,139,806 -69.3%
PFE June 30, 2025 4,350,200 $110,234,068 16.6%
VRTX Sept. 30, 2025 210,287 $93,619,772 38.1%
TERN March 31, 2026 2,153,300 $86,993,320 No longer tracked
MRK March 31, 2025 829,900 $82,558,452 68.6%
THC Sept. 30, 2025 465,000 $81,840,000 36.0%
BIIB March 31, 2025 509,100 $77,851,572 59.8%
IONS June 30, 2025 2,540,136 $76,635,903 52.7%
APLS March 31, 2026 2,429,868 $61,038,284 No longer tracked
UHS March 31, 2025 319,300 $57,288,806 -6.3%
CI March 31, 2026 205,000 $56,422,150 6.0%
RAPT March 31, 2026 1,642,891 $55,644,718 No longer tracked
PFE June 30, 2026 1,946,500 $54,657,720 17.4%
UTHR March 31, 2026 105,200 $51,258,700 -10.0%
DHR June 30, 2026 265,800 $50,395,680 10.3%
SWTX June 30, 2025 1,122,800 $49,549,164 No longer tracked
ROIV March 31, 2026 2,190,907 $47,542,682 33.8%
RNA March 31, 2026 619,530 $44,686,699 -1.6%
NBIX March 31, 2026 314,240 $44,568,659 18.0%
ASND June 30, 2026 181,977 $41,623,599 -4.0%
SIBN Dec. 31, 2025 2,578,979 $37,962,571 -0.3%
EXAS March 31, 2026 351,716 $35,720,277 No longer tracked
CYTK Sept. 30, 2025 1,077,000 $35,584,080 39.5%
XTNT June 30, 2025 73,114,592 $34,363,858 No longer tracked
SCPH Dec. 31, 2025 6,059,528 $34,357,524 No longer tracked
THRD Sept. 30, 2025 5,779,071 $31,380,356 No longer tracked
ITGR Dec. 31, 2025 290,000 $29,965,700 59.6%
ESPR June 30, 2026 10,570,300 $28,962,622 No longer tracked
BRKR March 31, 2026 555,789 $26,183,220 65.9%
AKRO Dec. 31, 2025 526,200 $24,983,976 No longer tracked
GILD June 30, 2025 197,500 $22,129,875 33.9%
BTSG June 30, 2026 497,800 $21,211,258 -15.5%
ABT Dec. 31, 2025 150,000 $20,091,000 -8.4%
MLYS March 31, 2025 1,611,637 $19,839,251 72.1%
AGIO Sept. 30, 2025 557,900 $18,555,754 -11.7%
VSTM June 30, 2025 2,862,448 $17,260,561 81.0%
MNMD March 31, 2026 1,226,700 $16,425,513 No longer tracked
CTMX March 31, 2026 3,525,650 $15,019,269 -25.1%
MEDP March 31, 2025 44,900 $14,917,127 99.2%
VIR March 31, 2026 2,380,715 $14,355,711 11.0%
AMGN June 30, 2026 39,900 $14,038,815 21.2%
ALHC June 30, 2026 791,000 $13,937,420 -44.9%
AMGN June 30, 2025 44,200 $13,770,510 57.2%
ITCI March 31, 2025 163,000 $13,613,760 No longer tracked
TARS March 31, 2026 154,400 $12,642,272 3.3%
VERA June 30, 2025 481,065 $11,555,181 40.1%
AZN Dec. 31, 2025 150,000 $11,508,000 79.4%
ABCL Sept. 30, 2025 3,344,568 $11,471,868 134.3%
REGN June 30, 2026 14,700 $11,357,808 34.8%
CARL June 30, 2026 1,252,600 $11,336,030 45.8%
FOLD March 31, 2026 729,900 $10,393,776 No longer tracked
AMLX Dec. 31, 2025 750,600 $10,200,654 211.1%
QGEN June 30, 2026 250,000 $10,010,000 12.0%
SLRN June 30, 2025 4,001,711 $9,884,226 No longer tracked
CPRX Sept. 30, 2025 416,900 $9,046,730 No longer tracked
RPTX March 31, 2026 3,322,488 $8,638,469 No longer tracked
CELC March 31, 2026 85,664 $8,544,127 -16.9%
NMRA March 31, 2025 804,996 $8,532,958 66.0%
GILD June 30, 2026 59,600 $8,306,452 17.5%
XBI June 30, 2025 100,000 $8,110,000 No longer tracked
ZLAB Sept. 30, 2025 231,000 $8,078,070 -19.9%
HRTX June 30, 2026 9,816,940 $7,854,534 -28.8%
VSTM Dec. 31, 2025 887,561 $7,837,164 -2.7%
TYRA Sept. 30, 2025 804,603 $7,700,051 89.6%
GERN March 31, 2025 2,168,000 $7,674,720 -0.9%
AVTX June 30, 2026 475,165 $7,094,213 11.0%
ITOS Sept. 30, 2025 700,000 $6,979,000 No longer tracked
MIST Dec. 31, 2025 3,221,828 $6,443,656 -46.0%
CMPS June 30, 2026 1,150,646 $6,363,072 -1.5%
KMTS June 30, 2025 250,000 $6,230,000 72.4%
PMVP March 31, 2026 4,975,291 $6,219,114 0.0%
ADCT June 30, 2026 1,318,026 $4,942,598 -2.8%
SRRK June 30, 2025 151,800 $4,880,370 56.0%
IKNA Sept. 30, 2025 3,539,358 $4,742,740 No longer tracked
MIST March 31, 2025 2,000,000 $4,720,000 36.3%
INSM March 31, 2026 25,400 $4,420,616 -21.2%
IMTX Dec. 31, 2025 466,601 $3,975,441 -12.1%
BCAX June 30, 2025 298,301 $3,886,862 181.7%
SRRK Dec. 31, 2025 100,000 $3,724,000 25.4%
TGTX Dec. 31, 2025 100,000 $3,612,500 71.4%
ARDT March 31, 2025 206,000 $3,518,480 -18.6%
CGEM June 30, 2026 243,006 $3,453,115 19.1%
SLNO June 30, 2026 100,000 $3,348,000 No longer tracked
JBIO June 30, 2026 185,011 $2,599,405 4.4%
PEPG March 31, 2025 653,016 $2,474,931 106.4%
ENGN Sept. 30, 2025 677,977 $2,467,836 -74.4%
CCCC June 30, 2026 856,353 $2,252,208 -8.9%
CBLL June 30, 2025 112,500 $2,161,125 33.7%
TIL June 30, 2025 116,785 $2,027,388 -64.9%
LYELXXXX March 31, 2025 3,103,623 $1,986,319 No longer tracked
IMVT March 31, 2025 78,500 $1,944,445 163.1%
OCUL March 31, 2026 157,300 $1,909,622 34.9%
KALV June 30, 2026 94,400 $1,900,272 No longer tracked
ATAI Dec. 31, 2025 347,000 $1,835,630 78.5%
CRDF June 30, 2025 573,884 $1,801,996 -71.3%
VTGN June 30, 2026 3,060,000 $1,748,790 5.2%
XFORXXXX June 30, 2025 6,776,515 $1,601,968 No longer tracked
KRRO Dec. 31, 2025 32,400 $1,551,636 73.2%
NKTX June 30, 2025 821,400 $1,511,376 52.5%
FATE June 30, 2025 1,680,580 $1,327,826 137.1%
MURA Dec. 31, 2025 588,800 $1,218,816 No longer tracked
TSBX Sept. 30, 2025 3,099,265 $1,112,636 No longer tracked
CMMB Sept. 30, 2025 940,990 $1,091,548 -27.0%
PHGE June 30, 2025 1,787,767 $993,462 No longer tracked
MPLT March 31, 2026 56,000 $952,000 -41.9%
LYEL Dec. 31, 2025 51,727 $840,046 -45.2%
TNGX June 30, 2025 550,000 $753,500 409.3%
KZR Dec. 31, 2025 192,700 $751,530 No longer tracked
XERS Dec. 31, 2025 80,420 $654,619 14.1%
IVVD June 30, 2025 933,500 $565,048 28.0%
NXTC June 30, 2025 1,141,200 $548,118 25.4%
ELEV March 31, 2025 941,275 $529,561 No longer tracked
PASG Dec. 31, 2025 59,046 $474,139 -61.4%
DHAI Dec. 31, 2025 1,915,000 $358,105 No longer tracked
INMB Sept. 30, 2025 50,000 $115,500 4.8%
LSBCF Sept. 30, 2025 54,799 $55,895 No longer tracked