ORBIMED ADVISORS LLC
CIK 1055951 · View on SEC EDGAR ↗
- Portfolio value
- $5.4B
- Positions
- 129
- As of
- June 30, 2026
Portfolio value QoQ: +8.3% 13F does not disclose cash
- Top 10 holdings weight
- 42.10%
- Top 25 holdings weight
- 62.79%
- Positions above 1%
- 31
- Effective number of positions
- 31.9
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 20.87% Est. buys $1,083,352,679 · sells $1,363,417,556
Median holding: 3.0 quarters Tracked Q4 2024–Q2 2026 · 51.0% still held
- New positions
- 42
- Increased
- 33
- Decreased
- 26
- Closed
- 24
Put-notional exposure: 0.9% puts 13F reports option positions at underlying notional value — may include hedges, not necessarily bearish bets
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- High-conviction bets The holdings this manager is most concentrated in.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
- Related The person behind this filer, where we can match one.
Performance vs S&P 500
Annualized: +34.5% · S&P 500: +18.0%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 97.9% · Options excluded: 2.4%
Sector breakdown
Full portfolio 129 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| EWTX Edgewise Therapeutics, Inc. - Common Stock | $630,516,330 | 11.68% | 15,518,492 | $141,683,832 | |||
| ELVN Enliven Therapeutics, Inc. - Common Stock | $343,914,074 | 6.37% | 6,776,632 | $31,900,184 | Down ×1 | ||
| LLY Eli Lilly and Company Common Stock | $309,332,997 | 5.73% | 257,900 | $91,531,461 | Up ×1 | ||
| MBX MBX Biosciences, Inc. - Common Stock | $189,266,227 | 3.51% | 3,428,736 | $80,675,300 | Down ×3 | ||
| SVA Sinovac Biotech, Ltd. - Ordinary Shares (Antigua/Barbudo) | $184,466,170 | 3.42% | 2,718,735 | $0 | |||
| AZN AstraZeneca PLC - American Depositary Shares | $171,079,502 | 3.17% | 915,700 | $38,902,658 | Up ×1 | ||
| GPCR Structure Therapeutics Inc. - American Depositary Shares | $118,578,498 | 2.20% | 2,209,400 | $47,464,073 | Up ×3 | ||
| SION Sionna Therapeutics, Inc. - Common Stock | $112,433,029 | 2.08% | 2,555,877 | $-29,112,814 | Down ×3 | ||
| CRVS Corvus Pharmaceuticals, Inc. - Common Stock | $107,045,190 | 1.98% | 7,165,006 | $2,221,152 | |||
| AVBP ArriVent BioPharma, Inc. - Common Stock | $105,169,375 | 1.95% | 3,027,328 | $35,328,918 | |||
| GH Guardant Health, Inc. - Common Stock | $87,572,511 | 1.62% | 583,700 | $47,373,087 | Up ×1 | ||
| ARGX argenx SE - American Depositary Shares | $86,171,278 | 1.60% | 92,880 | $-13,799,947 | Down ×4 | ||
| MRK Merck & Company, Inc. Common Stock (new) | $85,246,900 | 1.58% | 663,400 | $5,446,514 | |||
| QURE uniQure N.V. - Ordinary Shares | $83,252,805 | 1.54% | 1,807,486 | $48,326,769 | Down ×1 | ||
| PRAX Praxis Precision Medicines, Inc. - Common Stock | $77,035,179 | 1.43% | 230,100 | $21,457,404 | Up ×2 | ||
| EW Edwards Lifesciences Corporation Common Stock | $75,525,054 | 1.40% | 834,900 | $-23,021,394 | Down ×2 | ||
| PRLD Prelude Therapeutics Incorporated - Common Stock | $73,151,963 | 1.36% | 13,724,571 | $35,842,307 | Up ×1 | ||
| ABVX Abivax SA - American Depositary Shares | $72,829,522 | 1.35% | 546,522 | $20,973,827 | Up ×2 | ||
| DYN Dyne Therapeutics, Inc. - Common Stock | $71,864,542 | 1.33% | 3,235,684 | $18,963,305 | Up ×2 | ||
| NTRA Natera, Inc. - Common Stock | $71,119,900 | 1.32% | 262,000 | $18,722,520 | |||
| CGON CG Oncology, Inc. - Common stock | $69,117,440 | 1.28% | 972,800 | $4,938,729 | Up ×1 | ||
| UNH UnitedHealth Group Incorporated Common Stock (DE) | $66,957,993 | 1.24% | 161,100 | ||||
| SPRY ARS Pharmaceuticals, Inc. - Common Stock | $66,390,965 | 1.23% | 8,288,510 | $-165,770 | |||
| Unknown issuer (CUSIP: K08588103) | $65,201,304 | 1.21% | 244,456 | Up ×1 | |||
| HUM Humana Inc. Common Stock | $65,183,802 | 1.21% | 164,100 | Up ×1 | |||
| COGT Cogent Biosciences, Inc. - Common Stock | $65,066,310 | 1.21% | 1,681,300 | $52,668,681 | Up ×1 | ||
| BSX Boston Scientific Corporation Common Stock | $63,302,976 | 1.17% | 1,483,200 | $-86,173,799 | Down ×4 | ||
| ISRG Intuitive Surgical, Inc. - Common Stock | $62,793,672 | 1.16% | 157,900 | $-33,414,941 | Down ×4 | ||
| MLYS Mineralys Therapeutics, Inc. - Common Stock | $56,935,894 | 1.05% | 2,110,300 | $1,322,833 | Up ×2 | ||
| Unknown issuer (CUSIP: 67613T104) | $56,152,415 | 1.04% | 3,001,198 | Up ×1 | |||
| XENE Xenon Pharmaceuticals Inc. - Common Shares | $53,869,550 | 1.00% | 892,471 | $-7,767,764 | Down ×1 | ||
| ARQT Arcutis Biotherapeutics, Inc. - Common stock | $53,541,240 | 0.99% | 2,042,000 | Up ×1 | |||
| BMY Bristol-Myers Squibb Company Common Stock | $53,298,500 | 0.99% | 925,000 | $-2,802,750 | |||
| QTTB Q32 Bio Inc. - Common Stock | $52,590,554 | 0.97% | 4,127,987 | $38,126,377 | Up ×1 | ||
| SYK Stryker Corporation Common Stock | $50,091,044 | 0.93% | 159,100 | $-9,876,631 | Down ×3 | ||
| CAI Caris Life Sciences, Inc. - Common Stock | $50,017,372 | 0.93% | 2,806,811 | $-168,409 | |||
| XBI XBI | $47,475,000 | 0.88% | 300,000 | Put option | Up ×1 | ||
| TMO Thermo Fisher Scientific Inc Common Stock | $45,473,352 | 0.84% | 90,700 | $22,617,207 | Up ×1 | ||
| PVLA Palvella Therapeutics, Inc. - Common Stock | $44,678,455 | 0.83% | 292,360 | $27,900,565 | Up ×1 | ||
| ELV Elevance Health, Inc. Common Stock | $44,357,931 | 0.82% | 114,700 | $10,779,506 | |||
| STTK Shattuck Labs, Inc. - Common Stock | $43,764,521 | 0.81% | 6,306,127 | $3,216,124 | |||
| UPB Upstream Bio, Inc. - Common Stock | $39,399,636 | 0.73% | 5,693,589 | $-11,842,665 | |||
| CRNX Crinetics Pharmaceuticals, Inc. - Common Stock | $37,382,580 | 0.69% | 999,000 | $1,098,900 | |||
| RYTM Rhythm Pharmaceuticals, Inc. - Common Stock | $35,851,587 | 0.66% | 322,900 | $8,534,310 | Up ×3 | ||
| SNDX Syndax Pharmaceuticals, Inc. - Common Stock | $33,708,120 | 0.62% | 1,542,000 | $11,228,792 | Up ×1 | ||
| FBRX Forte Biosciences, Inc. - Common Stock | $33,526,231 | 0.62% | 1,577,705 | $2,525,096 | Up ×1 | ||
| CMPX Compass Therapeutics, Inc. - Common Stock | $33,331,787 | 0.62% | 15,219,994 | $-47,181,981 | |||
| NKTR Nektar Therapeutics - Common Stock | $32,485,804 | 0.60% | 465,346 | $12,699,554 | Up ×1 | ||
| KRYS Krystal Biotech, Inc. - Common Stock | $30,922,944 | 0.57% | 83,200 | $13,073,032 | Up ×1 | ||
| Unknown issuer (CUSIP: 000000000) | $30,275,391 | 0.56% | 5,680,186 | $27,621,826 | Up ×1 | ||
| AXSM Axsome Therapeutics, Inc. - Common Stock | $28,779,567 | 0.53% | 117,578 | $-7,377,360 | Down ×3 | ||
| KNSA Kiniksa Pharmaceuticals International, plc - Class A Ordinary Shares | $26,897,370 | 0.50% | 420,600 | $18,201,528 | Up ×1 | ||
| TRVI Trevi Therapeutics, Inc. - Common Stock | $26,674,964 | 0.49% | 1,430,293 | $-2,606,028 | Down ×3 | ||
| ABVX Abivax SA - American Depositary Shares | $26,652,000 | 0.49% | 200,000 | Call option | Up ×1 | ||
| IRON Disc Medicine, Inc. - Common Stock | $26,150,110 | 0.48% | 357,535 | $-42,109,037 | Down ×1 | ||
| WST West Pharmaceutical Services, Inc. Common Stock | $25,345,400 | 0.47% | 70,600 | Up ×1 | |||
| RLMD Relmada Therapeutics, Inc. - Common Stock | $25,127,869 | 0.47% | 3,631,195 | $-7,694,544 | Down ×1 | ||
| URGN UroGen Pharma Ltd. - Ordinary Shares | $24,883,682 | 0.46% | 676,187 | $9,142,426 | Down ×1 | ||
| STRO Sutro Biopharma, Inc. - Common Stock | $24,698,941 | 0.46% | 743,944 | $4,742,444 | Down ×1 | ||
| SVRA Savara, Inc. - Common Stock | $24,392,984 | 0.45% | 3,959,900 | $20,925,884 | Up ×1 | ||
| NPCE Neuropace, Inc. - Common Stock | $23,916,436 | 0.44% | 1,505,125 | $-3,652,894 | Down ×3 | ||
| AURA Aura Biosciences, Inc. - Common Stock | $23,666,664 | 0.44% | 3,333,333 | Up ×1 | |||
| ORIC Oric Pharmaceuticals, Inc. - Common Stock | $21,822,450 | 0.40% | 2,015,000 | $-12,309,630 | Down ×2 | ||
| HELP Cybin Inc. - Common Stock | $21,623,954 | 0.40% | 3,271,400 | $3,226,308 | Down ×2 | ||
| BCRX BioCryst Pharmaceuticals, Inc. - Common Stock | $18,520,000 | 0.34% | 1,852,000 | $4,952,096 | Up ×1 | ||
| BIOA BioAge Labs, Inc. - Common Stock | $18,435,270 | 0.34% | 752,153 | $5,985,696 | Up ×1 | ||
| PTGX Protagonist Therapeutics, Inc. - Common Stock | $18,387,000 | 0.34% | 150,000 | Call option | Up ×1 | ||
| LXEO Lexeo Therapeutics, Inc. - Common Stock | $18,377,242 | 0.34% | 3,947,850 | $-2,300,821 | Up ×2 | ||
| WHWK Whitehawk Therapeutics, Inc. - Common Stock | $18,019,076 | 0.33% | 3,934,296 | $3,646,376 | Down ×1 | ||
| DFTX Definium Therapeutics, Inc. - Common Shares | $17,188,416 | 0.32% | 365,400 | $1,992,816 | Down ×1 | ||
| SYRE Spyre Therapeutics, Inc. - Common Stock | $16,525,953 | 0.31% | 186,145 | Up ×1 | |||
| CRBP Corbus Pharmaceuticals Holdings, Inc. - Common Stock | $16,295,752 | 0.30% | 1,737,287 | $-17,373 | |||
| VERA Vera Therapeutics, Inc. - Class A Common Stock | $15,859,364 | 0.29% | 369,596 | $990,517 | |||
| ALMS Alumis Inc. - Common Stock | $15,425,307 | 0.29% | 548,163 | $3,349,276 | |||
| EYPT EyePoint, Inc. - Common Stock | $15,288,802 | 0.28% | 1,069,147 | $1,507,497 | |||
| WAT Waters Corporation Common Stock | $15,114,112 | 0.28% | 40,300 | Up ×1 | |||
| MNPR Monopar Therapeutics Inc. - Common Stock | $14,575,796 | 0.27% | 157,423 | Up ×1 | |||
| TVTX Travere Therapeutics, Inc. - Common Stock | $14,372,930 | 0.27% | 253,000 | Up ×1 | |||
| TSHA Taysha Gene Therapies, Inc. - Common Stock | $13,620,000 | 0.25% | 2,000,000 | Up ×1 | |||
| BIIB Biogen Inc. - Common Stock | $13,309,296 | 0.25% | 61,600 | $2,016,168 | |||
| RVMD Revolution Medicines, Inc. - Common Stock | $13,203,240 | 0.24% | 70,500 | $8,146,240 | Up ×2 | ||
| DNTH Dianthus Therapeutics, Inc. - Common Stock | $11,210,200 | 0.21% | 115,000 | Up ×1 | |||
| SPRB Spruce Biosciences, Inc. - Common Stock | $10,800,000 | 0.20% | 200,000 | Up ×1 | |||
| LFST LifeStance Health Group, Inc. - Common Stock | $10,146,654 | 0.19% | 947,400 | $6,961,654 | Up ×1 | ||
| RVMD Revolution Medicines, Inc. - Common Stock | $9,364,000 | 0.17% | 50,000 | Call option | Up ×1 | ||
| ERAS Erasca, Inc. - Common Stock | $9,084,888 | 0.17% | 495,900 | Up ×1 | |||
| TARA Protara Therapeutics, Inc. - Common Stock | $8,480,400 | 0.16% | 2,220,000 | Up ×1 | |||
| KROS Keros Therapeutics, Inc. - common stock | $8,122,959 | 0.15% | 759,155 | $-258,112 | |||
| JANX Janux Therapeutics, Inc. - Common Stock | $8,059,392 | 0.15% | 524,700 | $-5,612,648 | Down ×2 | ||
| TECX Tectonic Therapeutic, Inc. - Common Stock | $7,789,375 | 0.14% | 226,600 | $785,169 | |||
| ACET Adicet Bio, Inc. - Common Stock | $7,298,960 | 0.14% | 844,787 | $298,661 | Down ×1 | ||
| PHVS Pharvaris N.V. - Ordinary Shares | $7,102,732 | 0.13% | 205,400 | $1,300,182 | |||
| ANRO Alto Neuroscience, Inc. Common Stock | $6,804,714 | 0.13% | 257,852 | $3,039,314 | Up ×2 | ||
| ZNTL Zentalis Pharmaceuticals, Inc. - common stock | $6,744,294 | 0.12% | 1,390,576 | Up ×1 | |||
| DRUG Bright Minds Biosciences Inc. - common stock | $6,528,600 | 0.12% | 93,000 | $3,609,800 | Up ×1 | ||
| PVLA Palvella Therapeutics, Inc. - Common Stock | $6,112,800 | 0.11% | 40,000 | Call option | $-119,700 | Down ×1 | |
| ALXO ALX Oncology Holdings Inc. - Common Stock | $5,933,150 | 0.11% | 2,866,256 | $186,307 | |||
| Unknown issuer (CUSIP: 89422GAB3) | $5,894,350 | 0.11% | 5,000,000 | Up ×1 | |||
| Unknown issuer (CUSIP: 98422T209) | $5,674,234 | 0.11% | 592,300 | Up ×1 | |||
| BCAX Bicara Therapeutics Inc. - Common Stock | $5,673,759 | 0.11% | 191,100 | $-7,598,838 | Down ×1 | ||
| No matches | |||||||
Conviction holdings
Positions increased for 3+ consecutive quarters.
Share counts are as reported in 13F filings (not split-adjusted)
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| UNH | $66,957,993 | 161,100 | 1.24% |
| Unknown issuer (CUSIP: K08588103) | $65,201,304 | 244,456 | 1.21% |
| HUM | $65,183,802 | 164,100 | 1.21% |
| Unknown issuer (CUSIP: 67613T104) | $56,152,415 | 3,001,198 | 1.04% |
| ARQT | $53,541,240 | 2,042,000 | 0.99% |
| XBI | $47,475,000 | 300,000 | 0.88% |
| ABVX | $26,652,000 | 200,000 | 0.49% |
| WST | $25,345,400 | 70,600 | 0.47% |
| AURA | $23,666,664 | 3,333,333 | 0.44% |
| PTGX | $18,387,000 | 150,000 | 0.34% |
| SYRE | $16,525,953 | 186,145 | 0.31% |
| WAT | $15,114,112 | 40,300 | 0.28% |
| MNPR | $14,575,796 | 157,423 | 0.27% |
| TVTX | $14,372,930 | 253,000 | 0.27% |
| TSHA | $13,620,000 | 2,000,000 | 0.25% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| EWTX | Price move only | +0 | +$141.7M |
| LLY | Bought more | +21K | +$91.5M |
| BSX | Trimmed | -899K | -$86.2M |
| MBX | Trimmed | -209K | +$80.7M |
| QURE | Trimmed | -329K | +$48.3M |
| GPCR | Bought more | +734K | +$47.5M |
| GH | Bought more | +148K | +$47.4M |
| CMPX | Price move only | +0 | -$47.2M |
| IRON | Trimmed | -710K | -$42.1M |
| AZN | Bought more | +246K | +$38.9M |
1 position hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| MDXH | June 30, 2026 | 124,306,000 | $285,903,800 | 91.6% |
| RCEL | June 30, 2026 | 41,510,995 | $156,458,309 | 132.4% |
| MYGN | June 30, 2026 | 125,000,000 | $122,875,000 | -46.8% |
| UNH | Sept. 30, 2025 | 386,300 | $120,514,011 | 14.4% |
| SRPT | March 31, 2025 | 963,400 | $117,139,806 | -69.3% |
| PFE | June 30, 2025 | 4,350,200 | $110,234,068 | 16.6% |
| VRTX | Sept. 30, 2025 | 210,287 | $93,619,772 | 38.1% |
| TERN | March 31, 2026 | 2,153,300 | $86,993,320 | No longer tracked |
| MRK | March 31, 2025 | 829,900 | $82,558,452 | 68.6% |
| THC | Sept. 30, 2025 | 465,000 | $81,840,000 | 36.0% |
| BIIB | March 31, 2025 | 509,100 | $77,851,572 | 59.8% |
| IONS | June 30, 2025 | 2,540,136 | $76,635,903 | 52.7% |
| APLS | March 31, 2026 | 2,429,868 | $61,038,284 | No longer tracked |
| UHS | March 31, 2025 | 319,300 | $57,288,806 | -6.3% |
| CI | March 31, 2026 | 205,000 | $56,422,150 | 6.0% |
| RAPT | March 31, 2026 | 1,642,891 | $55,644,718 | No longer tracked |
| PFE | June 30, 2026 | 1,946,500 | $54,657,720 | 17.4% |
| UTHR | March 31, 2026 | 105,200 | $51,258,700 | -10.0% |
| DHR | June 30, 2026 | 265,800 | $50,395,680 | 10.3% |
| SWTX | June 30, 2025 | 1,122,800 | $49,549,164 | No longer tracked |
| ROIV | March 31, 2026 | 2,190,907 | $47,542,682 | 33.8% |
| RNA | March 31, 2026 | 619,530 | $44,686,699 | -1.6% |
| NBIX | March 31, 2026 | 314,240 | $44,568,659 | 18.0% |
| ASND | June 30, 2026 | 181,977 | $41,623,599 | -4.0% |
| SIBN | Dec. 31, 2025 | 2,578,979 | $37,962,571 | -0.3% |
| EXAS | March 31, 2026 | 351,716 | $35,720,277 | No longer tracked |
| CYTK | Sept. 30, 2025 | 1,077,000 | $35,584,080 | 39.5% |
| XTNT | June 30, 2025 | 73,114,592 | $34,363,858 | No longer tracked |
| SCPH | Dec. 31, 2025 | 6,059,528 | $34,357,524 | No longer tracked |
| THRD | Sept. 30, 2025 | 5,779,071 | $31,380,356 | No longer tracked |
| ITGR | Dec. 31, 2025 | 290,000 | $29,965,700 | 59.6% |
| ESPR | June 30, 2026 | 10,570,300 | $28,962,622 | No longer tracked |
| BRKR | March 31, 2026 | 555,789 | $26,183,220 | 65.9% |
| AKRO | Dec. 31, 2025 | 526,200 | $24,983,976 | No longer tracked |
| GILD | June 30, 2025 | 197,500 | $22,129,875 | 33.9% |
| BTSG | June 30, 2026 | 497,800 | $21,211,258 | -15.5% |
| ABT | Dec. 31, 2025 | 150,000 | $20,091,000 | -8.4% |
| MLYS | March 31, 2025 | 1,611,637 | $19,839,251 | 72.1% |
| AGIO | Sept. 30, 2025 | 557,900 | $18,555,754 | -11.7% |
| VSTM | June 30, 2025 | 2,862,448 | $17,260,561 | 81.0% |
| MNMD | March 31, 2026 | 1,226,700 | $16,425,513 | No longer tracked |
| CTMX | March 31, 2026 | 3,525,650 | $15,019,269 | -25.1% |
| MEDP | March 31, 2025 | 44,900 | $14,917,127 | 99.2% |
| VIR | March 31, 2026 | 2,380,715 | $14,355,711 | 11.0% |
| AMGN | June 30, 2026 | 39,900 | $14,038,815 | 21.2% |
| ALHC | June 30, 2026 | 791,000 | $13,937,420 | -44.9% |
| AMGN | June 30, 2025 | 44,200 | $13,770,510 | 57.2% |
| ITCI | March 31, 2025 | 163,000 | $13,613,760 | No longer tracked |
| TARS | March 31, 2026 | 154,400 | $12,642,272 | 3.3% |
| VERA | June 30, 2025 | 481,065 | $11,555,181 | 40.1% |
| AZN | Dec. 31, 2025 | 150,000 | $11,508,000 | 79.4% |
| ABCL | Sept. 30, 2025 | 3,344,568 | $11,471,868 | 134.3% |
| REGN | June 30, 2026 | 14,700 | $11,357,808 | 34.8% |
| CARL | June 30, 2026 | 1,252,600 | $11,336,030 | 45.8% |
| FOLD | March 31, 2026 | 729,900 | $10,393,776 | No longer tracked |
| AMLX | Dec. 31, 2025 | 750,600 | $10,200,654 | 211.1% |
| QGEN | June 30, 2026 | 250,000 | $10,010,000 | 12.0% |
| SLRN | June 30, 2025 | 4,001,711 | $9,884,226 | No longer tracked |
| CPRX | Sept. 30, 2025 | 416,900 | $9,046,730 | No longer tracked |
| RPTX | March 31, 2026 | 3,322,488 | $8,638,469 | No longer tracked |
| CELC | March 31, 2026 | 85,664 | $8,544,127 | -16.9% |
| NMRA | March 31, 2025 | 804,996 | $8,532,958 | 66.0% |
| GILD | June 30, 2026 | 59,600 | $8,306,452 | 17.5% |
| XBI | June 30, 2025 | 100,000 | $8,110,000 | No longer tracked |
| ZLAB | Sept. 30, 2025 | 231,000 | $8,078,070 | -19.9% |
| HRTX | June 30, 2026 | 9,816,940 | $7,854,534 | -28.8% |
| VSTM | Dec. 31, 2025 | 887,561 | $7,837,164 | -2.7% |
| TYRA | Sept. 30, 2025 | 804,603 | $7,700,051 | 89.6% |
| GERN | March 31, 2025 | 2,168,000 | $7,674,720 | -0.9% |
| AVTX | June 30, 2026 | 475,165 | $7,094,213 | 11.0% |
| ITOS | Sept. 30, 2025 | 700,000 | $6,979,000 | No longer tracked |
| MIST | Dec. 31, 2025 | 3,221,828 | $6,443,656 | -46.0% |
| CMPS | June 30, 2026 | 1,150,646 | $6,363,072 | -1.5% |
| KMTS | June 30, 2025 | 250,000 | $6,230,000 | 72.4% |
| PMVP | March 31, 2026 | 4,975,291 | $6,219,114 | 0.0% |
| ADCT | June 30, 2026 | 1,318,026 | $4,942,598 | -2.8% |
| SRRK | June 30, 2025 | 151,800 | $4,880,370 | 56.0% |
| IKNA | Sept. 30, 2025 | 3,539,358 | $4,742,740 | No longer tracked |
| MIST | March 31, 2025 | 2,000,000 | $4,720,000 | 36.3% |
| INSM | March 31, 2026 | 25,400 | $4,420,616 | -21.2% |
| IMTX | Dec. 31, 2025 | 466,601 | $3,975,441 | -12.1% |
| BCAX | June 30, 2025 | 298,301 | $3,886,862 | 181.7% |
| SRRK | Dec. 31, 2025 | 100,000 | $3,724,000 | 25.4% |
| TGTX | Dec. 31, 2025 | 100,000 | $3,612,500 | 71.4% |
| ARDT | March 31, 2025 | 206,000 | $3,518,480 | -18.6% |
| CGEM | June 30, 2026 | 243,006 | $3,453,115 | 19.1% |
| SLNO | June 30, 2026 | 100,000 | $3,348,000 | No longer tracked |
| JBIO | June 30, 2026 | 185,011 | $2,599,405 | 4.4% |
| PEPG | March 31, 2025 | 653,016 | $2,474,931 | 106.4% |
| ENGN | Sept. 30, 2025 | 677,977 | $2,467,836 | -74.4% |
| CCCC | June 30, 2026 | 856,353 | $2,252,208 | -8.9% |
| CBLL | June 30, 2025 | 112,500 | $2,161,125 | 33.7% |
| TIL | June 30, 2025 | 116,785 | $2,027,388 | -64.9% |
| LYELXXXX | March 31, 2025 | 3,103,623 | $1,986,319 | No longer tracked |
| IMVT | March 31, 2025 | 78,500 | $1,944,445 | 163.1% |
| OCUL | March 31, 2026 | 157,300 | $1,909,622 | 34.9% |
| KALV | June 30, 2026 | 94,400 | $1,900,272 | No longer tracked |
| ATAI | Dec. 31, 2025 | 347,000 | $1,835,630 | 78.5% |
| CRDF | June 30, 2025 | 573,884 | $1,801,996 | -71.3% |
| VTGN | June 30, 2026 | 3,060,000 | $1,748,790 | 5.2% |
| XFORXXXX | June 30, 2025 | 6,776,515 | $1,601,968 | No longer tracked |
| KRRO | Dec. 31, 2025 | 32,400 | $1,551,636 | 73.2% |
| NKTX | June 30, 2025 | 821,400 | $1,511,376 | 52.5% |
| FATE | June 30, 2025 | 1,680,580 | $1,327,826 | 137.1% |
| MURA | Dec. 31, 2025 | 588,800 | $1,218,816 | No longer tracked |
| TSBX | Sept. 30, 2025 | 3,099,265 | $1,112,636 | No longer tracked |
| CMMB | Sept. 30, 2025 | 940,990 | $1,091,548 | -27.0% |
| PHGE | June 30, 2025 | 1,787,767 | $993,462 | No longer tracked |
| MPLT | March 31, 2026 | 56,000 | $952,000 | -41.9% |
| LYEL | Dec. 31, 2025 | 51,727 | $840,046 | -45.2% |
| TNGX | June 30, 2025 | 550,000 | $753,500 | 409.3% |
| KZR | Dec. 31, 2025 | 192,700 | $751,530 | No longer tracked |
| XERS | Dec. 31, 2025 | 80,420 | $654,619 | 14.1% |
| IVVD | June 30, 2025 | 933,500 | $565,048 | 28.0% |
| NXTC | June 30, 2025 | 1,141,200 | $548,118 | 25.4% |
| ELEV | March 31, 2025 | 941,275 | $529,561 | No longer tracked |
| PASG | Dec. 31, 2025 | 59,046 | $474,139 | -61.4% |
| DHAI | Dec. 31, 2025 | 1,915,000 | $358,105 | No longer tracked |
| INMB | Sept. 30, 2025 | 50,000 | $115,500 | 4.8% |
| LSBCF | Sept. 30, 2025 | 54,799 | $55,895 | No longer tracked |