LXRX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $1.82
Market Cap (MRQ) $813M
P/E (TTM) -12.1
EPS (TTM) $-0.15
Revenue (TTM) $41M
ROE (TTM) -40.2%
Debt/Equity (MRQ) 0.3
52W Range $1–$3

LXRX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
range
bars

Bar granularity adapts to the selected period — hover the chart to see open/high/low/close for a bar.

Stock splits 1
Ex-date Split Type
May 21, 2015 1-for-7 Reverse

About Lexicon Pharmaceuticals, Inc. - Common Stock Company overview from Wikipedia

05 · wikidata

Lexicon Pharmaceuticals, Inc. is a biopharmaceutical company developing treatments for human disease. The company was founded in 1995 in The Woodlands, Texas under the name Lexicon Genetics, Incorporated by co-founders Professor Allan Bradley, FRS and Professor Bradley's postdoctoral fellow Arthur T Sands. The company has used its mouse gene knockout technology and in vivo screening capabilities to study nearly 5,000 genes in its Genome5000 program and has identified over 100 potential therapeutic targets. Lexicon has advanced multiple drug candidates into human clinical trials and has a broad and diverse pipeline of drug targets behind its clinical programs. Lexicon is pursuing drug targets in five therapeutic areas including oncology, gastroenterology, immunology, metabolism, and ophthalmology.

The company's clinical drug candidates include sotagliflozin (LX4211) for the treatment of type 2 diabetes; LX1033 for the treatment of irritable bowel syndrome and other gastrointestinal disorders; telotristat ethyl (LX1032) for the treatment of the symptoms associated with carcinoid syndrome; and LX2931 for the treatment of autoimmune diseases, such as rheumatoid arthritis.

Company history

Lexicon Pharmaceuticals was founded in September 1995 as a biotech venture of Baylor College of Medicine. The company went public in April 2000 with $220 million initial public offerings. In June, 2001 Lexicon purchased a privately owned small chemical library synthesis company, Coelacanth Corporation in Princeton, New Jersey, which became the site for the company's small molecule and medicinal chemistry efforts. The company's original name was Lexicon Genetics Incorporated, but in 2007, the name changed to Lexicon Pharmaceuticals, Inc. to reflect a renewed focus on drug development.

The company initially focused on using gene knockout technology to define the function of genes. This effort complemented and benefited from the international effort to sequence the human and mouse genomes (see Human Genome Project). Using its proprietary gene trapping and gene targeting technologies, the company created A repository of genetically modified mouse embryonic stem cells, known as OmniBank, and established a large-scale mammalian knockout program to discover the physiological and behavioral functions of the most druggable mammalian genes. The information collected from this program is stored in the company's LexVision database, which contains almost 5,000 gene knockouts studied. Over the years, Lexicon evolved from a genomics company into a drug discovery and development company focused on discovering and developing treatments for human disease. The company currently has multiple drug candidates in various stages of clinical trials.

In 2016, the company was ranked #8 on the Deloitte Fast 500 North America list.

Technology

Lexicon uses patented gene trapping and gene targeting technologies to generate and study knockout mice to discover the physiological and behavioral effects that result from the disruption of a single gene knockout. Because there is a close similarity in gene function and physiology between mice and humans, with a large majority of human genes having a counterpart in the mouse genome, knockout mouse technology has become a powerful tool in the discovery of new medicines.

The value of Lexicon's technology in drug discovery has been described in a retrospective analysis by the scientific journal Nature. The conclusion of this analysis was that, in most cases, there was a direct correlation when comparing the physiological characteristics, or phenotypes, of knockout mice to the therapeutic effect of the 100 best-selling drugs of 2001. The tremendous utility of knockout mouse technology was recognized in 2007 with the Nobel Prize in Physiology or Medicine to Drs. Mario Capecchi, Martin Evans, and Oliver Smithies.

In developing small molecule drugs for its validated targets, Lexicon uses medicinal chemistry known as "click chemistry." Dr. K. Barry Sharpless, who was awarded the 2001 Nobel Prize in Chemistry, developed this tools for the rapid synthesis of novel compounds. Lexicon uses solution-phase chemistry to generate diverse libraries of optically pure compounds that are built using organic reactions that allow the company to generate collections of different compounds and to tailor the compound collections to address various therapeutic target families. Lexicon's medicinal chemists design these libraries by analyzing the chemical structures of drugs that have been proven safe and effective against human disease and using that knowledge in the design of scaffolds and chemical building blocks for the generation of large numbers of new drug-like compounds.

Locations

Lexicon operates from two locations found in Texas and New Jersey. The corporate headquarters are in The Woodlands, Texas just north of Houston. This location serves as Lexicon's primary research facility to discover and validate the company's drug targets and test drug candidates in preclinical research. The company's clinical development and regulatory team is also based at the corporate headquarters.

Lexicon's campus in Princeton, New Jersey is the home of Lexicon's small molecule medicinal chemistry and preclinical development efforts. This site serves as Lexicon's primary medicinal chemistry site to create new chemical entities for therapeutic development.

== References ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

sectorHealthcare industryPharmaceuticals employees81 countryUS

10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$50M
2016-12-31 → 2025-12-31
EPS$-0.14
2017-12-31 → 2025-12-31
Free Cash Flow$-68M
2016-12-31 → 2025-12-31
Net margin-147.4%
2016-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend LXRX 5Y avg Peer Median Verdict
P/E (TTM) -12.15Y avg ≈-4.2 ≈-4.2 · ·
P/S (TTM) 19.65Y avg ≈1530.9 ≈1530.9 6.6 Overvalued
P/B (MRQ) 4.75Y avg ≈4.1 ≈4.1 3.8 Overvalued
EV / EBITDA (TTM) -12.5 · · ·
Price / FCF -9.85Y avg ≈-5.6 ≈-5.6 · ·
Price / Cash Flow -9.85Y avg ≈-5.7 ≈-5.7 · ·
EV / Revenue (TTM) 16.3 · · ·
EV / FCF -9.2 · · ·
Price / Tangible Book 10.65Y avg ≈6.7 ≈6.7 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise 48.2%
Next Report Nov 13, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 4, 2026 $-0.07 $-0.05 -36.7%
March 31, 2026 May 11, 2026 $0.00 $-0.04 100.0%
Dec. 31, 2025 $-0.04 $-0.07 43.2%
Sept. 30, 2025 $-0.04 $-0.07 40.6%
June 30, 2025 $0.01 $-0.08 112.6%
March 31, 2025 $-0.07 $-0.10 29.6%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 16
Metric Trend 202520242023202220212020201920182017201620152014
Revenue $50M$31M$1M$139.0K$298.0K$24M$322M$63M$92M$79M$130M$23M
Cost of Revenue $274.0K$616.0K$85.0K$0$0$2M$3M$2M$2M$0$0·
R&D Expense $61M$84M$59M$53M$55M$154M$92M$100M$152M$164M$95M$89M
SG&A Expense $37M$143M$114M$48M$32M$47M$57M$64M$66M$43M$24M$19M
Operating Expenses $99M$228M$173M$101M$87M$204M$181M$166M$222M$206M$129M$123M
Operating Income $-49M$-197M$-172M$-101M$-87M$-48M$141M$-103M$-131M$-127M$1M$-100M
Interest Expense ···$3M$802.0K$15M$21M$21M$7M$7M$7M$2M
Other Non-op $7M$12M$8M$2M$134.0K$3M$3M$4M$2M$2M$572.0K$2M
Pretax Income ····$-88M$-59M$124M$-121M$-136M$-131M$-5M$-100M
Income Tax ·$0$0$0$0····$0$0$-70.0K
Net Income $-50M$-200M$-177M$-102M$-88M$-59M$130M$-121M$-123M$-131M$-5M$-100M
EPS (Basic) $-0.14$-0.63$-0.80$-0.62$-0.60$-0.53$1.23$-1.14$-1.17···
EPS (Diluted) $-0.14$-0.63$-0.80$-0.62$-0.60$-0.53$1.16$-1.14$-1.17···
Shares (Basic) 363,053,000320,031,000221,130,000165,733,000145,652,000·······
Shares (Diluted) 363,053,000320,031,000221,130,000165,733,000145,652,000110,841,000116,747,000105,830,000105,237,000···
EBITDA $-48M$-197M$-171M$-100M$-87M$-45M$145M$-100M$-133M$-135M·$-98M
Balance Sheet 30
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents $34M$67M$22M$46M$64M$126M$36M$80M$62M$47M$203M$137M
Short-term Investments $62M$171M$148M$92M$23M$26M$236M$80M$249M$300M$318M$202M
Receivables $2M$3M$1M$28.0K$14.0K$395.0K$57M$6M$5M$7M$911.0K$1M
Inventory $281.0K$231.0K$381.0K$0·$0$4M$5M$2M$0··
Other Current Assets $3M$5M$5M$2M$2M$5M$5M$3M$4M$4M$10M$5M
Current Assets $102M$246M$177M$141M$89M$158M$338M$173M$322M$358M$532M$369M
PP&E (Net) $2M$2M$2M$2M$1M$295.0K$14M$16M$18M$19M$21M$1M
PP&E (Gross) $5M$5M$7M$6M$6M$6M$76M$76M$76M$79M$81M$37M
Accum. Depreciation $3M$2M$5M$4M$5M$6M$62M$60M$59M$60M$59M$36M
Goodwill $45M$45M$45M$45M$45M$45M$45M$45M$45M$45M$45M$45M
Intangibles ······$20M$50M$52M$53M$53M$53M
Other Non-current Assets $368.0K$368.0K$828.0K$412.0K$2M$1M$2M$285.0K$429.0K$461.0K$433.0K$3M
Total Assets $185M$298M$229M$194M$137M$204M$418M$284M$437M$476M$652M$471M
Accounts Payable $3M$15M$14M$10M$9M$5M$12M$12M$39M$53M$20M$13M
Accrued Liabilities $13M$30M$17M$13M$13M$30M$42M$21M$12M$32M$25M$10M
Current Liabilities $21M$45M$32M$23M$22M$47M$65M$37M$105M$165M$123M$45M
Capital Leases $7M$5M$5M$5M········
Deferred Tax ······$0$6M$6M$19M$19M$19M
Other Non-current Liabilities $7M$7M$5M$5M$1M$611.0K$1M$238.0K$292.0K$805.0K$14M$24M
Total Liabilities $77M$152M$136M$77M$23M$47M$301M$311M$368M$318M$366M$187M
Long-term Debt $54M$100M·$49M$0$12M$249M$250M$252M$101M$106M$108M
Total Debt $54M$100M$100M·$0$12M$245M$245M$246M$101M·$108M
Common Stock $366.0K$363.0K$245.0K$189.0K$150.0K$142.0K$106.0K$106.0K$106.0K$105.0K$104.0K$104.0K
Paid-in Capital $2.13B$2.12B$1.86B$1.71B$1.61B$1.56B$1.46B$1.45B$1.44B$1.41B$1.40B$1.39B
Retained Earnings $-2.02B$-1.97B$-1.77B$-1.59B$-1.49B$-1.40B$-1.34B$-1.47B$-1.37B$-1.25B$-1.11B$-1.10B
Treasury Stock $5M$5M$3M$2M$8M$5M$4M$3M$2M$3M$3M$2M
AOCI $30.0K$119.0K$31.0K$-428.0K$-10.0K$-6.0K$84.0K$-12.0K$-222.0K$-195.0K$-219.0K$-63.0K
Stockholders' Equity $108M$146M$93M$117M$114M$156M$117M$-26M$68M$168M$286M$284M
Liabilities + Equity $185M$298M$229M$194M$137M$204M$418M$284M$437M$476M$652M$471M
Shares Outstanding 365,848,216363,020,303·189,214,000150,082,000142,289,000106,679,000106,162,000105,711,000104,582,000103,860,000103,663,000
Cash Flow 17
Metric Trend 202520242023202220212020201920182017201620152014
D&A $621.0K$534.0K$554.0K$427.0K$292.0K$3M$4M$4M$3M$2M$727.0K$2M
Stock-based Comp $13M$13M$14M$12M$11M$13M$14M$12M$9M$7M$7M$7M
Deferred Tax ···$0$0$0$-6M$0$-13M$0$0$-70.0K
Amort. of Intangibles ·······$2M$2M···
Other Non-cash $-31M$8M$328.0K$1M$-10M$-101M$-28M$-43M$-57M$-44M·$16M
Operating Cash Flow $-68M$-179M$-162M$-89M$-87M$-143M$114M$-149M$-185M$-176M$185M$-76M
CapEx $0$1M$470.0K$1M$1M$87.0K$70.0K$95.0K$228.0K$231.0K$910.0K$80.0K
Investing Cash Flow $113M$-15M$-50M$-71M$2M$381M$-156M$170M$51M$18M$-117M$-108M
Debt Issued $0$0$50M$49M·$0$0$13M$146M$0$0$84M
Net Debt Issued $0$0·$49M$-12M$-217M$-1M$-2M$144M$-2M·$82M
Stock Issued $0$0$139M$94M$37M$70M$0$732.0K$8M$4M$114.0K$202M
Stock Repurchased ·$2M$824.0K$864.0K$3M$1M$941.0K$972.0K$2M$621.0K$357.0K$887.0K
Net Stock Activity $0$-2M$138M$93M$34M$69M$-941.0K$-240.0K$6M$3M·$201M
Financing Cash Flow $-48M$238M$188M$142M$23M$-148M$-2M$-2M$150M$987.0K$-2M$284M
Net Change in Cash $-3M$44M$-24M$-18M$-62M$90M$-44M$19M$15M$-156M$66M$100M
Free Cash Flow $-68M$-180M$-162M$-90M$-88M$-143M$114M$-149M$-186M$-176M·$-76M
Levered FCF ·········$-182M·$-78M
Profitability 7
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin -98.2%-634.2%-14264.9%-72489.2%-29224.8%-199.2%43.9%-163.4%-151.3%-164.6%·-439.2%
Net Margin -101.1%-644.8%-14710.9%-73341.0%-29449.0%-244.1%40.4%-190.7%-142.9%-169.7%·-438.8%
Pretax Margin ····-29449.0%-244.1%38.5%-190.7%-156.9%-169.7%·-439.1%
EBITDA Margin -97.0%-632.5%-14218.9%-72182.0%-29126.9%-187.0%45.1%-157.6%-147.5%-162.1%·-430.7%
ROA -20.8%-75.9%-83.6%-61.6%-51.5%-18.9%37.1%-33.5%-28.3%-25.1%·-26.9%
ROE -39.7%-167.7%-168.5%-88.4%-65.0%-42.8%287.0%-576.0%-117.5%-63.8%·-44.2%
ROIC ·········-53.0%·-25.6%
Liquidity & Solvency 5
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 4.95.45.66.14.03.45.24.72.62.2·8.2
Quick Ratio 4.75.35.46.03.93.35.04.52.52.2·7.6
Debt / Equity 0.50.71.1·0.00.12.1-9.34.70.6·0.4
LT Debt / Equity 0.50.71.1··0.02.0-9.24.40.5·0.3
Interest Coverage ···-36.2-108.6-3.36.8-5.0-19.6-20.9·-44.5
Efficiency 3
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 0.20.10.00.00.00.10.90.20.20.1·0.1
Inventory Turnover 1.12.00.4··0.90.70.81.9···
Receivables Turnover 17.013.92.36.61.50.810.311.814.719.8·25.0
Per Share 5
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share $0.29··$0.62$0.76$1.10$1.10$-0.25$0.49$1.50·$0.39
Revenue / Share $0.14$0.10$0.01·$0.00$0.22$2.76·····
Cash Flow / Share $-0.19$-0.56$-0.73·$-0.60$-1.29$0.97·····
Cash / Share $0.09··$0.24$0.43$0.89$0.34$0.76$0.58$0.45·$0.19
EPS (TTM) $-0.14$-0.63$-0.80$-0.62$-0.60$-0.53$1.16$-1.14$-1.17$-0.12$-0.12·
Growth Rates 3
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 60.2%2481.5%766.2%-53.4%-98.8%·······
Revenue CAGR 3Y 610.2%370.7%-63.1%·········
Revenue CAGR 5Y 15.7%···········
Valuation (TTM) 14
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM $50M$31M$1M$139.0K$298.0K$24M$322M$63M$92M$79M$130M$23M
Net Income TTM $-50M$-200M$-177M$-102M$-88M$-59M$130M$-121M$-123M$-131M$-5M$-100M
Market Cap $421M··$361M$591M$487M$443M$705M$1.04B$1.45B·$4.62B
Enterprise Value $378M···$505M$346M$416M$790M$979M$1.20B·$4.39B
P/E -8.2-1.2-1.9-3.1-6.6-6.53.6-5.8-8.4-115.2-110.9·
P/S 8.4··2600.01984.320.31.411.211.418.2·202.3
P/B 3.9··3.15.23.13.8-26.720.09.2·16.3
P / Tangible Book 6.7··5.08.64.4······
P / Cash Flow -6.2··-4.1-6.8-3.43.9-4.7-5.6-8.2·-61.1
P / FCF -6.2··-4.0-6.7-3.43.9-4.7-5.6-8.2·-61.1
EV / EBITDA -7.8···-5.8-7.72.9-7.9-7.3-8.9·-44.6
EV / FCF -5.6···-5.7-2.43.7-5.3-5.3-6.8·-58.0
EV / Revenue 7.6···1693.214.41.312.510.715.2·192.1
Earnings Yield -12.2%-85.1%-52.3%-32.5%-15.2%-15.5%28.0%-17.2%-11.8%-0.87%-0.90%·

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $50M $31M $1M $139.0K $298.0K
Operating Margin % -98.2% -634.2% -14264.9% -72489.2% -29224.8%
Net Income $-50M $-200M $-177M $-102M $-88M
Diluted EPS $-0.14 $-0.63 $-0.80 $-0.62 $-0.60

Institutional owners (13F) 167 filers · $890.0M total · As of June 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 167
Value held $890.0M
New positions 43
Exited positions 27
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
43 (+9 vs prior Q) 27 (+14 vs prior Q) 39 (-5 vs prior Q) 38 (+14 vs prior Q) +42.4M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Artal Group S.A. $420,374,549 175,156,062 47.23% Shares
FMR LLC $124,276,907 51,782,045 13.96% Shares
Siren, L.L.C. $106,328,443 44,303,518 11.95% Shares
Sessa Capital IM, L.P. $45,506,006 18,960,836 5.11% Shares
BlackRock, Inc. $41,636,978 17,348,741 4.68% Shares
VANGUARD CAPITAL MANAGEMENT LLC $23,762,899 9,901,208 2.67% Shares
Point72 Asset Management, L.P. $19,803,180 8,251,325 2.23% Shares
GEODE CAPITAL MANAGEMENT, LLC $14,989,739 6,244,372 1.68% Shares
STATE STREET CORP $11,802,646 4,917,769 1.33% Shares
VANGUARD GROUP INC $11,047,532 9,606,549 1.24% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $5,658,598 2,357,749 0.64% Shares
NORTHERN TRUST CORP $4,724,686 1,968,619 0.53% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $4,696,260 1,956,775 0.53% Shares
VANGUARD FIDUCIARY TRUST CO $3,922,970 1,634,571 0.44% Shares
CITADEL ADVISORS LLC $3,842,837 1,601,182 0.43% Shares
CIBC Private Wealth Group LLC $3,240,347 2,400,257 0.36% Shares
Ishara Investments LP $3,050,400 1,271,000 0.34% Shares
MILLENNIUM MANAGEMENT LLC $2,722,150 1,134,229 0.31% Shares
RENAISSANCE TECHNOLOGIES LLC $2,704,800 1,127,000 0.30% Shares
MACKENZIE FINANCIAL CORP $2,312,050 963,354 0.26% Shares
ADAR1 Capital Management, LLC $1,800,000 750,000 0.20% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,672,262 696,776 0.19% Shares
UBS Group AG $1,643,312 684,713 0.18% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,604,400 668,500 0.18% Call option
TWO SIGMA INVESTMENTS, LP $1,544,266 643,444 0.17% Shares
Nuveen, LLC $1,407,994 586,664 0.16% Shares
JANE STREET GROUP, LLC $1,398,960 582,900 0.16% Call option
Bank of New York Mellon Corp $1,364,893 568,706 0.15% Shares
Invesco Ltd. $1,219,370 508,071 0.14% Shares
GOLDMAN SACHS GROUP INC $1,165,310 485,546 0.13% Shares
Compagnie Lombard Odier SCmA $1,152,000 480,000 0.13% Shares
BANK OF AMERICA CORP /DE/ $1,011,117 421,299 0.11% Shares
BARCLAYS PLC $929,960 387,483 0.10% Shares
CITADEL ADVISORS LLC $886,320 369,300 0.10% Call option
XTX Topco Ltd $858,905 357,877 0.10% Shares
CANADA PENSION PLAN INVESTMENT BOARD $618,960 257,900 0.07% Shares
RHUMBLINE ADVISERS $616,523 256,885 0.07% Shares
DEUTSCHE BANK AG\ $594,068 247,528 0.07% Shares
WELLS FARGO & COMPANY/MN $553,128 230,470 0.06% Shares
WELLINGTON MANAGEMENT GROUP LLP $431,280 179,700 0.05% Shares
CITIGROUP INC $420,492 175,205 0.05% Shares
GROUP ONE TRADING LLC $420,031 175,013 0.05% Shares
Virtus Investment Advisers, LLC $408,996 170,415 0.05% Shares
Headlands Technologies LLC $401,275 167,198 0.05% Shares
Ikarian Capital, LLC $395,218 164,674 0.04% Shares
Quarry LP $374,846 156,186 0.04% Shares
MetLife Investment Management, LLC $351,384 146,410 0.04% Shares
MORGAN STANLEY $318,964 132,902 0.04% Shares
PANAGORA ASSET MANAGEMENT INC $316,901 132,042 0.04% Shares
JPMORGAN CHASE & CO $289,975 109,839 0.03% Shares

Show all 167 institutional owners →

Activists & 5%+ owners 11 positions

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Invus, L.P., Invus Advisors, L.L.C., Invus Public Equities, L.P., Invus Public Equities Advisors, LLC, Invus Global Management, LLC, Siren, L.L.C., Avicenna Life Sci Master Fund LP, Avicenna Life Sci Master GP LLC, Invus US Partners LLC, Ulys, L.L.C., Raymond Debbane, Artal Participations S.a r.l., Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., Stichting Administratiekantoor Westend, Amaury Wittouck ×7 filings May 8, 2026 39.40% Amendment · SEC
Invus, L.P. (2), Invus Advisors, L.L.C. (2), Invus Public Equities, L.P. (2), Invus Public Equities Advisors, LLC (2), Invus Global Management, LLC (2), Siren, L.L.C. (2), Artal Participations S.à r.l. (2), Artal International S.C.A. (2), Artal International Management S.A. (2), Artal Group S.A. (2), Westend S.A. (2), Stichting Administratiekantoor Westend (2), Mr. Amaury Wittouck (2), Invus US Partners LLC (2), Ulys, L.L.C. (2), Mr. Raymond Debbane (2) ×15 filings Dec. 9, 2024 · Initial filing · SEC
Feb. 24, 2012 · Initial filing · SEC
Raymond Debbane (2), Ulys, L.L.C. (2), Invus Advisors, L.L.C. (2), Invus, L.P. (2), Invus Public Equities Advisors, LLC (2), Invus Public Equities, L.P. (2), Invus C.V. (2) Dec. 27, 2011 · Initial filing · SEC
Nov. 14, 2011 · Initial filing · SEC
Aug. 15, 2011 · Initial filing · SEC
Raymond Debbane, Ulys, L.L.C., Invus Advisors, L.L.C., Invus, L.P., Invus Public Equities Advisors, LLC, Invus Public Equities, L.P., Invus C.V. March 19, 2010 · Initial filing Capital structure SEC
Estate of Gordon A. Cain (, Mary H. Cain ×4 filings Aug. 5, 2005 · Initial filing · SEC
Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person Aug. 8, 2003 · Initial filing · SEC
Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person July 18, 2003 · Initial filing Passive investment SEC
Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person March 19, 2003 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 49 insiders · 32 officers · 19 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Michael Exton Chief Executive Officer Feb. 28, 2026 M 298,432 0 0 $0
Lonnel Coats Chief Executive Officer Feb. 28, 2024 M 1,098,068 0 0 $0
Arthur T Sands President & CEO Feb. 28, 2014 M 1,021,329 0 0 $0
Scott M Coiante SVP, Chief Financial Officer Feb. 28, 2026 M 105,356 0 0 $0
Ajay Bansal EVP Corp Dev and CFO June 2, 2009 A · 0 0 $0
Julia P Gregory EVP and CFO Feb. 7, 2008 A 50,200 0 0 $0
Jeffrey L Wade President and COO July 8, 2024 A 324,214 0 0 $0
Rachel Yap Martens SVP, Partnerships & Corp Strat Feb. 28, 2026 M 31,264 0 0 $0
Suma Gopinathan SVP, Discovery Feb. 28, 2026 M 150,132 0 0 $0
Wendy Mcdermott SVP, Human Resources Feb. 28, 2026 M 277,945 0 0 $0
Craig B Granowitz SVP, Chief Medical Officer Feb. 28, 2026 M 323,430 0 0 $0
Lisa Defrancesco SVP, IR and Corp Comm Feb. 28, 2026 M 93,869 0 0 $0
Brian T Crum SVP, General Counsel & Secr. Feb. 28, 2026 M 428,802 0 0 $0
Kristen Alexander VP, Finance and Accounting Feb. 28, 2025 M 76,368 0 0 $0
Alan J Main EVP, Innov & Chem Sciences Feb. 28, 2025 M 339,104 0 0 $0
Brian Corrigan SVP, Regulatory & QA Feb. 13, 2025 A · 0 0 $0
Kenneth B. Kassler-Taub SVP, Regulatory & QA Feb. 28, 2024 M 162,672 0 0 $0
Thomas Garner SVP, Chief Commercial Officer Feb. 8, 2024 A · 0 0 $0
Kiernan Seth VP, Chief Commercial Officer Feb. 28, 2023 M 53,136 0 0 $0
James F Tessmer VP, Finance & Accounting March 15, 2021 M 71,766 0 0 $0
Alexander A Santini EVP and CCO April 22, 2020 F 55,584 0 0 $0
Pablo Lapuerta EVP and CMO April 22, 2020 F 85,719 0 0 $0
John Northcott VP, Marketing, Comm Strategy March 2, 2015 M 8,235 0 0 $0
Brian P Zambrowicz EVP, Chief Scientific Officer Feb. 28, 2014 M 278,703 0 0 $0
Steven Alan Tragash VP, Corporate Affairs Feb. 15, 2010 A · 0 0 $0
Philip M Brown SVP, Clinical Development Feb. 15, 2010 A 27,306 0 0 $0
James R Piggott PHD SVP of Pharm Bio Feb. 7, 2008 A 0 0 0 $0
Lance K Ishimoto SVP, Intellectual Property Feb. 7, 2008 A 10,200 0 0 $0
Tamar D Howson EVP of Bus Dev Feb. 7, 2008 A · 0 0 $0
Walter F Colbert SVP, HR and Corp Serv Feb. 13, 2007 A · 0 0 $0
Randall B Riggs SVP, Corp Licensing Feb. 23, 2004 M 15,000 0 0 $0
Christophe Person VP Informatics Jan. 12, 2004 M 0 0 0 $0
Ivan Cheung Director June 3, 2026 M 89,312 0 0 $0
Diane E. Sullivan Director June 3, 2026 M 126,122 0 0 $0
Judith L Swain Director June 3, 2026 M 174,486 0 0 $0
Amouyal Philippe Director June 3, 2026 M 374,486 0 0 $0
Sam L Barker Director June 3, 2026 M 213,771 0 0 $0
Christopher J Sobecki Director June 3, 2026 M 293,177 0 0 $0
Raymond Debbane Director June 3, 2026 M 1,995,498 7 0 $723,048
Robert J Lefkowitz MD Director May 13, 2024 A 48,364 0 0 $0
Frank Palantoni Director May 21, 2023 M 40,332 0 0 $0
Alan S Nies Director May 21, 2023 M 41,046 0 0 $0
Invus C.V. Director Dec. 31, 2020 J 0 0 0 $0
Kathleen M Wiltsey Director April 24, 2009 A · 0 0 $0
Clayton Stuart Rose Director June 26, 2007 P 25,000 0 0 $0
Barry Mills Director April 26, 2007 A 25,000 0 0 $0
Patricia M Cloherty Director April 27, 2006 A · 0 0 $0
Thomas C Caskey Director Oct. 13, 2005 P 6,300 0 0 $0
Praveen Tyle · Feb. 28, 2021 M 120,791 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 16 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBC · ETFis Series Trust I 0.81% 161,882 NS July 31, 2026 N-PORT
PILL · Direxion Shares ETF Trust 0.45% 40,310 NS July 31, 2026 N-PORT
QQQS · Invesco Exchange-Traded Fund Trust … 0.43% 53,319 SH Oct. 1, 2026 Daily
IWC · iShares Trust 0.12% 842,323 SH Sept. 11, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.04% 266,401 SH Aug. 19, 2026 Daily
IWO · iShares Trust 0.03% 2,343,443 SH Sept. 11, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.02% 1,432,882 SH Aug. 19, 2026 Daily
RSSL · Global X Funds 0.02% 118,391 NS July 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 260,485 SH Sept. 30, 2026 Daily
IWM · iShares Trust 0.02% 6,319,224 SH Sept. 11, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.01% 2,594,934 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 637,561 SH Aug. 19, 2026 Daily
WSML · iShares Trust 0.01% 17,992 SH Sept. 11, 2026 Daily
IWV · iShares Trust 0.00% 85,389 SH Sept. 3, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 7,083,651 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 20,905 SH Aug. 19, 2026 Daily

LXRX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 11 analysts BUY
Median target $4.55 +150.0%
3 27.3% Strong Buy
5 45.5% Buy
3 27.3% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

6 analysts · 2026-09-30

Mean target $4.55 +149.8%

← Below all targets Current price $1.82
Low$2.00 Mean$4.55 High$8.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
LXRX $421M -8.2 60.2% -101.1% -39.7% ·
ANRO $568M -8.1 · · -46.1% ·
ALMS · -3.4 · -1011.8% -61.9% ·
APMD · · · · · ·
SGP · · · · 50.0% ·
COLL $1.47B 26.8 23.6% 8.1% 23.5% 59.4%
ACRS $363M -5.7 -58.2% -829.6% -55.3% ·
ZVRA $509M 6.6 350.9% 78.2% 61.2% ·
AQST $788M -8.3 -22.6% -188.1% 157.7% ·
PHAT $1.18B -5.5 216.9% -126.4% 52.4% 87.1%

Latest News Recent headlines mentioning this company

23

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

Pick the metrics that matter to you — click the + next to any row in Full Fundamentals above.

Your selection is saved and follows you across all tickers.

Source: SEC 10-Q filed Aug 6, 2026