LXRX — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Artal Group S.A. | $420,374,549 | 175,156,062 | 47.23% | Shares |
| FMR LLC | $124,276,907 | 51,782,045 | 13.96% | Shares |
| Siren, L.L.C. | $106,328,443 | 44,303,518 | 11.95% | Shares |
| Sessa Capital IM, L.P. | $45,506,006 | 18,960,836 | 5.11% | Shares |
| BlackRock, Inc. | $41,636,978 | 17,348,741 | 4.68% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $23,762,899 | 9,901,208 | 2.67% | Shares |
| Point72 Asset Management, L.P. | $19,803,180 | 8,251,325 | 2.23% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $14,989,739 | 6,244,372 | 1.68% | Shares |
| STATE STREET CORP | $11,802,646 | 4,917,769 | 1.33% | Shares |
| VANGUARD GROUP INC | $11,047,532 | 9,606,549 | 1.24% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $5,658,598 | 2,357,749 | 0.64% | Shares |
| NORTHERN TRUST CORP | $4,724,686 | 1,968,619 | 0.53% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4,696,260 | 1,956,775 | 0.53% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $3,922,970 | 1,634,571 | 0.44% | Shares |
| CITADEL ADVISORS LLC | $3,842,837 | 1,601,182 | 0.43% | Shares |
| CIBC Private Wealth Group LLC | $3,240,347 | 2,400,257 | 0.36% | Shares |
| Ishara Investments LP | $3,050,400 | 1,271,000 | 0.34% | Shares |
| MILLENNIUM MANAGEMENT LLC | $2,722,150 | 1,134,229 | 0.31% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $2,704,800 | 1,127,000 | 0.30% | Shares |
| MACKENZIE FINANCIAL CORP | $2,312,050 | 963,354 | 0.26% | Shares |
| ADAR1 Capital Management, LLC | $1,800,000 | 750,000 | 0.20% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,672,262 | 696,776 | 0.19% | Shares |
| UBS Group AG | $1,643,312 | 684,713 | 0.18% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,604,400 | 668,500 | 0.18% | Call option |
| TWO SIGMA INVESTMENTS, LP | $1,544,266 | 643,444 | 0.17% | Shares |
| Nuveen, LLC | $1,407,994 | 586,664 | 0.16% | Shares |
| JANE STREET GROUP, LLC | $1,398,960 | 582,900 | 0.16% | Call option |
| Bank of New York Mellon Corp | $1,364,893 | 568,706 | 0.15% | Shares |
| Invesco Ltd. | $1,219,370 | 508,071 | 0.14% | Shares |
| GOLDMAN SACHS GROUP INC | $1,165,310 | 485,546 | 0.13% | Shares |
| Compagnie Lombard Odier SCmA | $1,152,000 | 480,000 | 0.13% | Shares |
| BANK OF AMERICA CORP /DE/ | $1,011,117 | 421,299 | 0.11% | Shares |
| BARCLAYS PLC | $929,960 | 387,483 | 0.10% | Shares |
| CITADEL ADVISORS LLC | $886,320 | 369,300 | 0.10% | Call option |
| XTX Topco Ltd | $858,905 | 357,877 | 0.10% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $618,960 | 257,900 | 0.07% | Shares |
| RHUMBLINE ADVISERS | $616,523 | 256,885 | 0.07% | Shares |
| DEUTSCHE BANK AG\ | $594,068 | 247,528 | 0.07% | Shares |
| WELLS FARGO & COMPANY/MN | $553,128 | 230,470 | 0.06% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $431,280 | 179,700 | 0.05% | Shares |
| CITIGROUP INC | $420,492 | 175,205 | 0.05% | Shares |
| GROUP ONE TRADING LLC | $420,031 | 175,013 | 0.05% | Shares |
| Virtus Investment Advisers, LLC | $408,996 | 170,415 | 0.05% | Shares |
| Headlands Technologies LLC | $401,275 | 167,198 | 0.05% | Shares |
| Ikarian Capital, LLC | $395,218 | 164,674 | 0.04% | Shares |
| Quarry LP | $374,846 | 156,186 | 0.04% | Shares |
| MetLife Investment Management, LLC | $351,384 | 146,410 | 0.04% | Shares |
| MORGAN STANLEY | $318,964 | 132,902 | 0.04% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $316,901 | 132,042 | 0.04% | Shares |
| JPMORGAN CHASE & CO | $289,975 | 109,839 | 0.03% | Shares |
| State of Wyoming | $285,816 | 119,090 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $273,874 | 114,114 | 0.03% | Shares |
| Cornerstone Investment Partners, LLC | $272,974 | 113,739 | 0.03% | Shares |
| Cerity Partners LLC | $236,160 | 98,400 | 0.03% | Shares |
| ALGERT GLOBAL LLC | $221,160 | 92,150 | 0.02% | Shares |
| TWO SIGMA ADVISERS, LP | $208,124 | 180,977 | 0.02% | Shares |
| BANK OF NOVA SCOTIA | $207,857 | 86,607 | 0.02% | Shares |
| LPL Financial LLC | $203,799 | 84,916 | 0.02% | Shares |
| Vanguard Global Advisers, LLC | $187,070 | 77,946 | 0.02% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $180,552 | 75,230 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $176,165 | 73,402 | 0.02% | Shares |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | $171,426 | 71,427 | 0.02% | Shares |
| PRUDENTIAL FINANCIAL INC | $171,228 | 71,345 | 0.02% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $167,393 | 69,747 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $164,160 | 68,400 | 0.02% | Shares |
| TWO SIGMA SECURITIES, LLC | $159,300 | 66,375 | 0.02% | Shares |
| SEI INVESTMENTS CO | $153,449 | 63,937 | 0.02% | Shares |
| Straight Path Wealth Management | $150,398 | 62,666 | 0.02% | Shares |
| R Squared Ltd | $131,964 | 54,985 | 0.01% | Shares |
| Vanguard Personalized Indexing Management, LLC | $130,402 | 54,334 | 0.01% | Shares |
| Fortis Group Advisors, LLC | $120,000 | 50,000 | 0.01% | Shares |
| Schonfeld Strategic Advisors LLC | $118,642 | 49,435 | 0.01% | Shares |
| SCOTIA CAPITAL INC. | $117,291 | 48,871 | 0.01% | Shares |
| PROFUND ADVISORS LLC | $116,606 | 48,586 | 0.01% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $114,650 | 47,771 | 0.01% | Shares |
| AXQ CAPITAL, LP | $109,745 | 45,727 | 0.01% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $106,356 | 44,315 | 0.01% | Shares |
| ALLIANCEBERNSTEIN L.P. | $105,768 | 67,800 | 0.01% | Shares |
| WINTON GROUP Ltd | $103,680 | 43,200 | 0.01% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $101,978 | 42,491 | 0.01% | Shares |
| LMR Partners LLP | $98,618 | 41,091 | 0.01% | Shares |
| BANK OF MONTREAL /CAN/ | $96,000 | 40,000 | 0.01% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $90,672 | 37,780 | 0.01% | Shares |
| Cubist Systematic Strategies, LLC | $85,704 | 63,484 | 0.01% | Shares |
| Rafferty Asset Management, LLC | $81,816 | 34,090 | 0.01% | Shares |
| ProShare Advisors LLC | $78,212 | 32,588 | 0.01% | Shares |
| Leonteq Securities AG | $72,000 | 30,000 | 0.01% | Shares |
| Pathstone Holdings, LLC | $71,925 | 29,969 | 0.01% | Shares |
| PINNACLE ASSOCIATES LTD | $69,636 | 29,015 | 0.01% | Shares |
| SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ | $63,960 | 26,650 | 0.01% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $58,135 | 24,223 | 0.01% | Shares |
| Legal & General Group Plc | $58,044 | 24,185 | 0.01% | Shares |
| XPONANCE LLC | $57,031 | 23,763 | 0.01% | Shares |
| Graham Capital Management, L.P. | $56,498 | 23,541 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $55,166 | 22,986 | 0.01% | Shares |
| D. E. Shaw & Co., Inc. | $53,280 | 22,200 | 0.01% | Shares |
| Quadrature Capital Ltd | $52,795 | 21,998 | 0.01% | Shares |
| Invera Wealth Advisors, LLC | $48,000 | 20,000 | 0.01% | Shares |
| DIKER MANAGEMENT LLC | $48,000 | 20,000 | 0.01% | Shares |
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC | $48,000 | 20,000 | 0.01% | Shares |
| Russell Investments Group, Ltd. | $47,764 | 19,902 | 0.01% | Shares |
| Point72 Asia (Singapore) Pte. Ltd. | $47,282 | 35,024 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $46,766 | 19,486 | 0.01% | Shares |
| KWB Wealth | $46,736 | 40,640 | 0.01% | Shares |
| SBI Securities Co., Ltd. | $46,092 | 19,205 | 0.01% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $45,682 | 19,034 | 0.01% | Shares |
| CREDIT AGRICOLE S A | $45,540 | 18,975 | 0.01% | Shares |
| WOLVERINE TRADING, LLC | $43,785 | 31,500 | 0.00% | Put option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $42,960 | 17,900 | 0.00% | Put option |
| CITADEL ADVISORS LLC | $42,960 | 17,900 | 0.00% | Put option |
| WOLVERINE TRADING, LLC | $39,615 | 28,500 | 0.00% | Call option |
| CAPTRUST FINANCIAL ADVISORS | $36,770 | 15,321 | 0.00% | Shares |
| Callan Family Office, LLC | $33,816 | 14,090 | 0.00% | Shares |
| TRUIST FINANCIAL CORP | $33,600 | 14,000 | 0.00% | Shares |
| CIBC Bancorp USA Inc. | $32,976 | 13,740 | 0.00% | Shares |
| Gotham Asset Management, LLC | $32,705 | 13,627 | 0.00% | Shares |
| CIBC Asset Management Inc | $31,445 | 13,102 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $30,000 | 12,650 | 0.00% | Shares |
| WOLVERINE TRADING, LLC | $29,455 | 21,191 | 0.00% | Shares |
| HBK Sorce Advisory LLC | $28,876 | 11,786 | 0.00% | Shares |
| Squarepoint Ops LLC | $28,178 | 11,741 | 0.00% | Shares |
| Apollon Wealth Management, LLC | $27,307 | 11,378 | 0.00% | Shares |
| Mariner, LLC | $26,974 | 11,239 | 0.00% | Shares |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $26,949 | 12,139 | 0.00% | Shares |
| Perennial Investment Advisors, LLC | $26,376 | 10,990 | 0.00% | Shares |
| Cetera Investment Advisers | $25,258 | 10,524 | 0.00% | Shares |
| Berger Financial Group, Inc | $24,000 | 10,000 | 0.00% | Shares |
| NBT BANK, N.A. | $24,000 | 10,000 | 0.00% | Shares |
| SIMPLEX TRADING, LLC | $20,496 | 8,540 | 0.00% | Shares |
| CWM, LLC | $16,227 | 10,402 | 0.00% | Shares |
| H D Vest Advisory Services | $11,087 | 11,724 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $8,225 | 3,427 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $6,221 | 2,592 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $3,506 | 1,461 | 0.00% | Shares |
| Physician Wealth Advisors, Inc. | $3,389 | 1,412 | 0.00% | Shares |
| Rialto Wealth Management, LLC | $3,152 | 1,313 | 0.00% | Shares |
| Global Retirement Partners, LLC | $2,400 | 1,000 | 0.00% | Shares |
| Cassaday & Co Wealth Management LLC | $2,400 | 1,000 | 0.00% | Shares |
| MassMutual Private Wealth & Trust, FSB | $2,297 | 957 | 0.00% | Shares |
| Sterling Capital Management LLC | $2,098 | 874 | 0.00% | Shares |
| Aster Capital Management (DIFC) Ltd | $1,783 | 743 | 0.00% | Shares |
| Fortitude Family Office, LLC | $1,694 | 706 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $1,666 | 696,617 | 0.00% | Shares |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $1,200 | 500 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $960 | 400 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $953 | 397,219 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $908 | 356 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $720 | 300 | 0.00% | Shares |
| Janney Montgomery Scott LLC | $709 | 295,548 | 0.00% | Shares |
| Allworth Financial LP | $632 | 263 | 0.00% | Shares |
| Parallel Advisors, LLC | $593 | 247 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $491 | 204,391 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $390 | 163 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $377 | 157 | 0.00% | Shares |
| SYNTAX RESEARCH, INC. | $341 | 142 | 0.00% | Shares |
| Clearstead Advisors, LLC | $240 | 100 | 0.00% | Shares |
| Larson Financial Group LLC | $240 | 100 | 0.00% | Shares |
| COMERICA BANK | $140 | 122 | 0.00% | Shares |
| Arax Advisory Partners | $98 | 41 | 0.00% | Shares |
| HM PAYSON & CO | $89 | 37 | 0.00% | Shares |
| WEDBUSH SECURITIES INC | $48 | 20,000 | 0.00% | Shares |
| Point72 (DIFC) Ltd | $20 | 15 | 0.00% | Shares |
| Blume Capital Management, Inc. | $12 | 5 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $5 | 2 | 0.00% | Shares |
| Avion Wealth | $2 | 1,115 | 0.00% | Shares |
| Covestor Ltd | $0 | 81 | 0.00% | Shares |
| Motiv8 Investments LLC | $0 | 200 | 0.00% | Shares |