COLL Collegium Pharmaceutical, Inc. - Common Stock

NASDAQ · Pharmaceuticals · View on SEC EDGAR ↗
$28.42
Price · Aug 18, 2026
Fundamentals as of Aug 6, 2026

COLL Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$28.42
Market Cap
$901M
P/E (TTM)
16.4
EPS (TTM)
$1.73
Revenue (TTM)
$781M
Div Yield
ROE
23.5%
Debt/Equity
52W Range
$25 – $51

COLL Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $781M
10-point trend, +45520.5%
2016-12-31 2025-12-31
EPS $1.73
8-point trend, +245.4%
2018-12-31 2025-12-31
Free Cash Flow $328M
10-point trend, +533.7%
2016-12-31 2025-12-31
Margins 8.1%
6-point trend, +2.3%
2020-12-31 2025-12-31

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
COLL
Peer Median
P/E (TTM)
5-point trend, +166.5%
16.4
29.9
P/S (TTM)
5-point trend, -17.2%
1.2
14.4
P/B
5-point trend, +57.1%
3.0
4.4
Price / FCF
5-point trend, -27.6%
2.8

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
COLL
Peer Median
Gross Margin
5-point trend, +9.1%
59.4%
79.3%
Operating Margin
5-point trend, +261.2%
23.0%
Net Profit Margin
5-point trend, -68.8%
8.1%
0.70%
ROA
5-point trend, -64.6%
3.8%
-0.55%
ROE
5-point trend, -25.2%
23.5%
-2.5%
ROIC
5-point trend, +122.0%
40.4%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
COLL
Peer Median
Current Ratio
5-point trend, +39.2%
1.6
3.9
Quick Ratio
5-point trend, +30.0%
1.4

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
COLL
Peer Median
Revenue YoY
5-point trend, +181.9%
23.6%
Revenue CAGR 3Y
5-point trend, +181.9%
18.9%
Revenue CAGR 5Y
5-point trend, +181.9%
20.3%
EPS YoY
5-point trend, -7.0%
-7.0%
Net Income YoY
5-point trend, -12.1%
-9.1%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
COLL
Peer Median
EPS (Diluted)
5-point trend, -7.0%
$1.73

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
COLL
Peer Median

COLL Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 12 analysts
  • Strong Buy 3 25.0%
  • Buy 7 58.3%
  • Hold 2 16.7%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-08-18
Median target $51.00 +79.5%
Mean target $51.20 +80.2%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.03%
Period EPS Actual EPS Est Surprise
June 30, 2026 $1.92 $1.75 0.17%
March 31, 2026 $1.76 $1.62 0.14%
Dec. 31, 2025 $2.04 $2.37 -0.33%
Sept. 30, 2025 $2.25 $2.08 0.17%
June 30, 2025 $1.68 $1.65 0.03%
March 31, 2025 $1.49 $1.46 0.03%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
COLL $1.47B 26.8 23.6% 8.1% 23.5% 59.4%
LXRX $421M -8.2 60.2% -101.1% -39.7%
PCRX $1.06B 161.8 3.6% 0.97% 0.97%
AMPH $1.22B 13.2 -1.7% 13.6% 12.7% 49.5%
ACRS $363M -5.7 -58.2% -829.6% -55.3%
SGP 50.0%
PHAT $1.18B -5.5 216.9% -126.4% 52.4% 87.1%
CRMD $922M 5.7 617.0% 52.3% 52.1% 88.5%
LLY 46.8 44.7% 31.7% 101.2%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for COLL
Metric Trend 2025202420232022202120202019201820172016
Revenue 10-point trend, +45520.5% $781M $631M $567M $464M $277M $310M $297M $280M $28M $2M
Cost of Revenue 10-point trend, +148871.8% $317M $254M $241M $254M $126M $130M $194M $166M $3M $213.0K
Gross Profit 8-point trend, +303.8% $463M $377M $326M $209M $151M $180M $103M $115M · ·
R&D Expense 9-point trend, -100.0% · $0 $0 $4M $9M $10M $10M $9M $9M $15M
SG&A Expense 10-point trend, +253.2% $285M $210M $159M $172M $119M $114M $116M $127M $93M $81M
Operating Expenses 10-point trend, +196.1% $284M $207M $159M $176M $133M $124M $127M $135M $104M $96M
Operating Income 10-point trend, +290.9% $180M $170M $167M $33M $18M $56M $-24M $-21M $-75M $-94M
Interest Expense 7-point trend, +88558.5% · · $83M $63M $21M $29M $909.0K $20M · $94.0K
Other Non-op 2-point trend, +719.1% · · · · · · · · $582.0K $-94.0K
Pretax Income 8-point trend, +336.7% $93M $99M $76M $-29M $-3M $28M $-23M $-39M · ·
Income Tax 7-point trend, +29749000.00 $30M $29M $28M $-4M $-75M $830.0K $0 · · ·
Net Income 10-point trend, +166.8% $63M $69M $48M $-25M $72M $27M $-23M $-39M $-75M $-94M
EPS (Basic) 9-point trend, +151.0% $1.98 $2.14 $1.43 $-0.74 $2.05 $0.78 $-0.68 $-1.19 · $-3.88
EPS (Diluted) 8-point trend, +245.4% $1.73 $1.86 $1.29 $-0.74 $1.86 $0.76 $-0.68 $-1.19 · ·
Shares (Basic) 8-point trend, -3.8% 31,706,429 32,273,850 33,741,213 33,829,495 34,936,817 34,407,959 33,453,844 32,953,808 · ·
Shares (Diluted) 8-point trend, +20.5% 39,701,693 40,424,180 41,788,125 33,829,495 41,045,805 35,151,353 33,453,844 32,953,808 · ·
EBITDA 10-point trend, +292.3% $180M $170M $167M $33M $18M $56M $-23M $-20M $-75M $-93M
Balance Sheet 30
Annual Balance Sheet data for COLL
Metric Trend 2025202420232022202120202019201820172016
Cash & Equivalents 10-point trend, +50.9% $231M $71M $239M $174M $186M $174M $170M $147M $119M $153M
Short-term Investments 4-point trend, +155427000.00 $155M $92M $72M $0 · · · · · ·
Receivables 10-point trend, +9826.2% $211M $229M $180M $183M $106M $83M $73M $78M $10M $2M
Inventory 10-point trend, +3008.8% $41M $36M $32M $47M $17M $16M $10M $8M $2M $1M
Prepaid Expense 10-point trend, +1613.5% $33M $30M $15M $17M $6M $5M $3M $5M $3M $2M
Other Current Assets 10-point trend, +965.5% $3M $3M $93.0K $57.0K $27.0K $60.0K $141.0K $1M $456.0K $304.0K
Current Assets 10-point trend, +336.0% $691M $482M $538M $420M $316M $278M $256M $238M $133M $159M
PP&E (Net) 10-point trend, +1057.3% $12M $14M $16M $20M $19M $19M $12M $9M $2M $1M
PP&E (Gross) 10-point trend, +1104.9% $29M $28M $26M $26M $24M $22M $14M $11M $3M $2M
Accum. Depreciation 10-point trend, +1141.9% $17M $14M $10M $6M $5M $3M $2M $2M $2M $1M
Goodwill 4-point trend, +9.1% $146M $162M $134M $134M · · · · · ·
Intangibles 8-point trend, +1412.8% $670M $891M $422M $567M $269M $336M $30M $44M · ·
Other Non-current Assets 10-point trend, +9798.5% $20M $8M $825.0K $100.0K $87.0K $123.0K $178.0K $204.0K $161.0K $204.0K
Total Assets 10-point trend, +922.6% $1.66B $1.66B $1.14B $1.17B $692M $644M $306M $291M $136M $162M
Accounts Payable 10-point trend, +17.1% $11M $4M $9M $3M $4M $10M $6M $12M $6M $9M
Accrued Liabilities 10-point trend, +603.5% $62M $72M $38M $36M $29M $25M $33M $31M $9M $9M
Current Liabilities 10-point trend, +1619.1% $440M $510M $458M $434M $280M $239M $202M $189M $31M $26M
Capital Leases 7-point trend, -56.2% $4M $6M $6M $7M $8M $9M $9M · · ·
Deferred Tax 5-point trend, -100.0% $0 $54M $71M $95M $5M · · · · ·
Other Non-current Liabilities · · · · · · · $676.0K · ·
Total Liabilities 10-point trend, +4898.9% $1.36B $1.43B $948M $979M $489M $458M $219M $200M $31M $27M
Long-term Debt 3-point trend, +177.4% · · · · · · $12M $12M · $4M
Common Stock 10-point trend, +41.4% $41.0K $40.0K $38.0K $37.0K $36.0K $35.0K $34.0K $33.0K $33.0K $29.0K
Paid-in Capital 10-point trend, +74.5% $625M $590M $566M $538M $502M $519M $447M $429M $402M $358M
Retained Earnings 10-point trend, +54.7% $-101M $-164M $-233M $-281M $-256M $-333M $-360M $-337M $-298M $-223M
Treasury Stock 5-point trend, +419.1% $223M $198M $137M $62M $43M · · · · ·
AOCI 3-point trend, +2178.6% $319.0K $55.0K $14.0K · · · · · · ·
Stockholders' Equity 10-point trend, +123.6% $302M $229M $195M $195M $203M $186M $87M $92M $104M $135M
Liabilities + Equity 10-point trend, +922.6% $1.66B $1.66B $1.14B $1.17B $692M $644M $306M $291M $136M $162M
Shares Outstanding 10-point trend, +8.0% 31,707,608 31,440,155 31,868,549 33,848,936 33,655,402 34,612,054 33,678,840 33,265,629 32,770,678 29,364,100
Cash Flow 19
Annual Cash Flow data for COLL
Metric Trend 2025202420232022202120202019201820172016
D&A 4-point trend, +11.6% · · · · · · $731.0K $1M $594.0K $655.0K
Stock-based Comp 10-point trend, +624.1% $42M $32M $27M $23M $24M $22M $17M $14M $8M $6M
Deferred Tax 5-point trend, +67.1% $-26M $-27M $-2M $-8M $-78M · · · · ·
Amort. of Intangibles 9-point trend, +55792.2% $222M $165M $146M · $67M $61M $15M $110M $258.0K $397.0K
Restructuring · · · · $5M · · · · ·
Other Non-cash 4-point trend, +162.2% · · · · · · $33M $194M $-692.0K $13M
Operating Cash Flow 10-point trend, +538.8% $329M $205M $275M $124M $104M $94M $28M $169M $-67M $-75M
CapEx 10-point trend, +264.8% $2M $2M $461.0K $2M $2M $6M $6M $5M $990.0K $477.0K
Investing Cash Flow 10-point trend, -2034.1% $-64M $-288M $-71M $-574M $-2M $-374M $-6M $-24M $-990.0K $-3M
Debt Issued · · · · · · · $10M · ·
Net Debt Issued 3-point trend, -331.2% · · · · · $-12M · $10M $-3M ·
Stock Issued 3-point trend, -100.0% · · · · · · · $-30.0K $34M $137M
Stock Repurchased 5-point trend, -47.5% $25M $60M $75M $14M $48M · · · · ·
Net Stock Activity 8-point trend, -118.3% $-25M $-60M $-75M $-14M $-48M · · $-30.0K $34M $137M
Financing Cash Flow 10-point trend, -181.3% $-110M $-61M $-140M $437M $-89M $286M $2M $-117M $33M $136M
Net Change in Cash 2-point trend, -160.0% · · · · · · · · $-35M $58M
Taxes Paid 6-point trend, +12330.8% $60M $52M $24M $10M $3M $483.0K · · · ·
Free Cash Flow 10-point trend, +533.7% $328M $203M $274M $123M $102M $88M $21M $164M $-68M $-76M
Levered FCF 4-point trend, +266.5% · · $221M $68M $547M $60M · · · ·
Profitability 8
Annual Profitability data for COLL
Metric Trend 2025202420232022202120202019201820172016
Gross Margin 6-point trend, +2.3% 59.4% 59.8% 57.6% 45.1% 54.4% 58.0% · · · ·
Operating Margin 10-point trend, +100.4% 23.0% 26.9% 29.5% 7.2% 6.4% 18.1% -8.0% -7.4% -265.0% -5498.7%
Net Margin 10-point trend, +100.1% 8.1% 11.0% 8.5% -5.4% 25.8% 8.6% -7.7% -14.0% -262.9% -5504.1%
Pretax Margin 6-point trend, +33.4% 11.9% 15.6% 13.4% -6.2% -1.2% 8.9% · · · ·
EBITDA Margin 10-point trend, +100.4% 23.0% 26.9% 29.5% 7.2% 6.4% 18.1% -7.8% -7.0% -262.9% -5460.4%
ROA 10-point trend, +105.2% 3.8% 4.9% 4.2% -2.7% 10.7% 5.6% -7.6% -18.3% -50.3% -72.5%
ROE 10-point trend, +127.5% 23.5% 29.9% 25.7% -12.8% 31.5% 14.9% -26.5% -48.2% -62.6% -85.6%
ROIC 6-point trend, +37.9% 40.4% 52.1% 54.3% 14.8% -184.1% 29.3% · · · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for COLL
Metric Trend 2025202420232022202120202019201820172016
Current Ratio 10-point trend, -74.6% 1.6 0.9 1.2 1.0 1.1 1.2 1.3 1.3 4.2 6.2
Quick Ratio 10-point trend, -77.6% 1.4 0.8 1.1 0.8 1.0 1.1 1.2 1.2 4.1 6.1
Interest Coverage 7-point trend, +100.2% · · 2.0 0.5 0.8 1.9 -26.1 -1.0 · -1000.9
Efficiency 3
Annual Efficiency data for COLL
Metric Trend 2025202420232022202120202019201820172016
Asset Turnover 10-point trend, +3462.1% 0.5 0.4 0.5 0.5 0.4 0.7 1.0 1.3 0.2 0.0
Inventory Turnover 10-point trend, +2463.7% 8.3 7.5 6.1 8.0 7.6 10.3 22.2 34.4 1.7 0.3
Receivables Turnover 10-point trend, +120.8% 3.5 3.1 3.1 3.2 2.9 4.0 3.9 6.4 4.7 1.6
Per Share 5
Annual Per Share data for COLL
Metric Trend 2025202420232022202120202019201820172016
Book Value / Share 10-point trend, +107.1% $9.51 $7.28 $6.13 $5.76 $6.03 $5.37 $2.60 $2.75 $3.18 $4.59
Revenue / Share 6-point trend, +122.9% $19.66 $15.62 $13.56 $13.71 $6.75 $8.82 · · · ·
Cash Flow / Share 6-point trend, +210.4% $8.29 $5.07 $6.57 $3.67 $2.52 $2.67 · · · ·
Cash / Share 10-point trend, +39.8% $7.29 $2.24 $7.50 $5.13 $5.54 $5.03 $5.05 $4.41 $3.62 $5.22
EPS (TTM) 10-point trend, +184.4% $1.73 $1.86 $1.29 $-0.74 $1.86 $0.76 $-0.68 $-1.19 $-2.05 $-2.05
Growth Rates 9
Annual Growth Rates data for COLL
Metric Trend 2025202420232022202120202019201820172016
Revenue YoY 5-point trend, +321.0% 23.6% 11.4% 22.2% 67.6% -10.7% · · · · ·
Revenue CAGR 3Y 3-point trend, -15.0% 18.9% 31.6% 22.3% · · · · · · ·
Revenue CAGR 5Y 20.3% · · · · · · · · ·
EPS YoY 3-point trend, -104.8% -7.0% 44.2% · · 144.7% · · · · ·
EPS CAGR 3Y 2-point trend, -100.0% · 0.00% 19.3% · · · · · · ·
EPS CAGR 5Y 17.9% · · · · · · · · ·
Net Income YoY 3-point trend, -105.5% -9.1% 43.7% · · 167.3% · · · · ·
Net Income CAGR 3Y 2-point trend, -105.1% · -1.1% 21.6% · · · · · · ·
Net Income CAGR 5Y 18.6% · · · · · · · · ·
Valuation (TTM) 9
Annual Valuation (TTM) data for COLL
Metric Trend 2025202420232022202120202019201820172016
Revenue TTM 10-point trend, +45520.5% $781M $631M $567M $464M $277M $310M $297M $280M $28M $2M
Net Income TTM 10-point trend, +166.8% $63M $69M $48M $-25M $72M $27M $-23M $-39M $-75M $-94M
Market Cap 10-point trend, +221.1% $1.47B $901M $981M $785M $629M $693M $693M $571M $605M $457M
P/E 10-point trend, +452.4% 26.8 15.4 23.9 -31.4 10.0 26.4 -30.3 -14.4 -9.0 -7.6
P/S 10-point trend, -99.3% 1.9 1.4 1.7 1.7 2.3 2.2 2.3 2.0 21.2 267.2
P/B 10-point trend, +43.6% 4.9 3.9 5.0 4.0 3.1 3.7 7.9 6.2 5.8 3.4
P / Cash Flow 10-point trend, +173.2% 4.5 4.4 3.6 6.3 6.1 7.4 24.9 3.4 -9.0 -6.1
P / FCF 10-point trend, +174.0% 4.5 4.4 3.6 6.4 6.2 7.8 32.5 3.5 -8.9 -6.1
Earnings Yield 10-point trend, +128.4% 3.7% 6.5% 4.2% -3.2% 10.0% 3.8% -3.3% -6.9% -11.1% -13.2%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $781M$631M$567M$464M$277M
Gross Margin % 59.4%59.8%57.6%45.1%54.4%
Operating Margin % 23.0%26.9%29.5%7.2%6.4%
Net Income $63M$69M$48M$-25M$72M
Diluted EPS $1.73$1.86$1.29$-0.74$1.86
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 1.60.91.21.01.1
Quick Ratio 1.40.81.10.81.0
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $328M$203M$274M$123M$102M

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Trading Signals Recent buy/sell signals with entry price and risk/reward ratio

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Institutional owners (13F) 296 filers · $955.8M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
51 (+12 vs prior Q) 29 (-12 vs prior Q) 113 (+7 vs prior Q) 77 (+2 vs prior Q) +2.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FULLER & THALER ASSET MANAGEMENT, INC. $59,106,662 1,632,781 6.18% Shares
PRINCIPAL FINANCIAL GROUP INC $59,000,281 1,629,842 6.17% Shares
STATE STREET CORP $55,345,492 1,528,881 5.79% Shares
JANUS HENDERSON GROUP PLC $54,931,023 1,661,554 5.75% Shares
VANGUARD CAPITAL MANAGEMENT LLC $50,001,648 1,381,261 5.23% Shares
RENAISSANCE TECHNOLOGIES LLC $49,469,074 1,366,549 5.18% Shares
EVENTIDE ASSET MANAGEMENT, LLC $49,272,746 1,361,228 5.16% Shares
Rubric Capital Management LP $46,321,918 1,279,611 4.85% Shares
DIMENSIONAL FUND ADVISORS LP $28,532,840 788,200 2.99% Shares
GEODE CAPITAL MANAGEMENT, LLC $27,848,492 769,139 2.91% Shares
VICTORY CAPITAL MANAGEMENT INC $27,521,123 760,252 2.88% Shares
GOLDENTREE ASSET MANAGEMENT LP $26,920,882 744,889 2.82% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $26,790,932 740,081 2.80% Shares
MILLENNIUM MANAGEMENT LLC $26,676,685 736,925 2.79% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $22,513,504 621,920 2.36% Shares
AMERICAN CENTURY COMPANIES INC $17,796,897 491,627 1.86% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $17,614,956 486,601 1.84% Shares
GOLDMAN SACHS GROUP INC $15,634,165 431,883 1.64% Shares
Qube Research & Technologies Ltd $15,618,381 431,447 1.63% Shares
ROYCE & ASSOCIATES LP $12,020,753 332,065 1.26% Shares
LOOMIS SAYLES & CO L P $11,490,713 317,423 1.20% Shares
Assenagon Asset Management S.A. $11,182,795 308,917 1.17% Shares
VANGUARD FIDUCIARY TRUST CO $8,351,268 230,698 0.87% Shares
BANK OF AMERICA CORP /DE/ $7,060,665 195,046 0.74% Shares
Hillsdale Investment Management Inc. $6,935,920 191,600 0.73% Shares
PRUDENTIAL FINANCIAL INC $6,677,307 184,456 0.70% Shares
THIRD AVENUE MANAGEMENT LLC $6,611,749 182,645 0.69% Shares
FIRST TRUST ADVISORS LP $6,309,442 174,294 0.66% Shares
Brandywine Global Investment Management, LLC $6,044,234 130,545 0.63% Shares
Public Sector Pension Investment Board $5,620,810 155,271 0.59% Shares
FRANKLIN RESOURCES INC $4,779,957 132,043 0.50% Shares
PEREGRINE CAPITAL MANAGEMENT LLC $4,684,859 129,416 0.49% Shares
MORGAN STANLEY $4,430,195 122,381 0.46% Shares
Uniplan Investment Counsel, Inc. $4,212,333 116,362 0.44% Shares
Point72 Asset Management, L.P. $4,127,017 114,006 0.43% Shares
Ballast Asset Management, LP $4,058,418 112,111 0.42% Shares
TWO SIGMA INVESTMENTS, LP $3,862,685 106,704 0.40% Shares
BARCLAYS PLC $3,831,624 105,846 0.40% Shares
WELLS FARGO & COMPANY/MN $3,621,520 100,042 0.38% Shares
Quantinno Capital Management LP $3,569,030 98,592 0.37% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $3,418,003 94,420 0.36% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $3,237,836 89,443 0.34% Shares
FMR LLC $3,123,988 86,298 0.33% Shares
RHUMBLINE ADVISERS $3,087,081 85,279 0.32% Shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC $3,035,515 83,854 0.32% Shares
ENVESTNET ASSET MANAGEMENT INC $2,900,054 80,112 0.30% Shares
BlackRock, Inc. $2,843,619 78,553 0.30% Shares
Gotham Asset Management, LLC $2,767,164 76,441 0.29% Shares
Smith Group Asset Management, LLC $2,675,035 73,896 0.28% Shares
CREDIT AGRICOLE S A $2,658,673 73,444 0.28% Shares
BNP PARIBAS FINANCIAL MARKETS $2,626,491 72,555 0.27% Shares
Woodline Partners LP $2,611,432 72,139 0.27% Shares
Corient Private Wealth LP $2,603,733 71,898 0.27% Shares
CITADEL ADVISORS LLC $2,483,030 68,592 0.26% Shares
Artemis Investment Management LLP $2,482,343 68,573 0.26% Shares
TWO SIGMA ADVISERS, LP $2,453,900 53,000 0.26% Shares
WEDGE CAPITAL MANAGEMENT L L P/NC $2,359,644 71,353 0.25% Shares
Swiss National Bank $2,353,000 65,000 0.25% Shares
AMERIPRISE FINANCIAL INC $2,332,656 64,438 0.24% Shares
UBS Group AG $2,326,936 64,280 0.24% Shares
EXCHANGE TRADED CONCEPTS, LLC $2,109,265 58,267 0.22% Shares
Empowered Funds, LLC $2,045,445 56,504 0.21% Shares
MARSHALL WACE, LLP $2,017,934 55,744 0.21% Shares
MARTINGALE ASSET MANAGEMENT L P $1,996,611 55,155 0.21% Shares
EASTERN BANK $1,985,317 54,843 0.21% Shares
GLOBEFLEX CAPITAL L P $1,915,378 52,911 0.20% Shares
ZACKS INVESTMENT MANAGEMENT $1,906,741 52,672 0.20% Shares
Legal & General Group Plc $1,800,335 49,733 0.19% Shares
NewEdge Wealth, LLC $1,773,402 48,989 0.19% Shares
Integrated Quantitative Investments LLC $1,738,939 48,037 0.18% Shares
Squarepoint Ops LLC $1,733,871 47,897 0.18% Shares
Freestone Grove Partners LP $1,610,647 44,493 0.17% Shares
EASTERLY INVESTMENT PARTNERS LLC $1,601,162 44,231 0.17% Shares
XTX Topco Ltd $1,599,569 44,187 0.17% Shares
Jump Financial, LLC $1,548,382 42,773 0.16% Shares
CITIGROUP INC $1,512,291 41,776 0.16% Shares
AlphaQuest LLC $1,480,072 31,967 0.15% Shares
Cresset Asset Management, LLC $1,440,434 39,791 0.15% Shares
HSBC HOLDINGS PLC $1,423,547 39,609 0.15% Shares
Susquehanna Portfolio Strategies, LLC $1,422,479 39,295 0.15% Shares
INTECH INVESTMENT MANAGEMENT LLC $1,378,930 38,092 0.14% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,353,880 37,400 0.14% Put option
Vinva Investment Management Ltd $1,306,880 24,992 0.14% Shares
Kendall Capital Management $1,257,226 34,730 0.13% Shares
ACORN FINANCIAL ADVISORY SERVICES INC /ADV $1,162,925 32,125 0.12% Shares
ALLIANCEBERNSTEIN L.P. $1,157,781 35,010 0.12% Shares
Redwood Investments, LLC $1,106,449 37,067 0.12% Shares
SEGALL BRYANT & HAMILL, LLC $1,090,199 30,116 0.11% Shares
WELLINGTON MANAGEMENT GROUP LLP $1,059,031 29,255 0.11% Shares
FIFTH THIRD BANCORP $1,049,185 28,983 0.11% Shares
JENNISON ASSOCIATES LLC $1,036,623 28,636 0.11% Shares
Fortis Capital Advisors, LLC $994,305 27,467 0.10% Shares
Belpointe Asset Management LLC $994,305 27,467 0.10% Shares
Jefferies Financial Group Inc. $991,880 27,400 0.10% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $973,680 29,443 0.10% Shares
O'SHAUGHNESSY ASSET MANAGEMENT, LLC $956,694 26,428 0.10% Shares
VANGUARD ASSET MANAGEMENT, Ltd $920,421 25,426 0.10% Shares
Vanguard Global Advisers, LLC $910,539 25,153 0.10% Shares
EVOLVE PRIVATE WEALTH, LLC $900,113 24,865 0.09% Shares
Aquatic Capital Management LLC $878,610 24,271 0.09% Shares

Company insiders 26 insiders · 10 officers · 14 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Vikram Karnani President and CEO Nov. 12, 2024 A 105,972 0 0 $0
Joseph Ciaffoni President and CEO Feb. 12, 2024 F 444,867 0 0 $0
Colleen Tupper EVP & Chief Financial Officer March 21, 2025 S 156,667 0 0 $0
Paul Brannelly Executive Vice President & CFO Feb. 10, 2021 F 215,428 0 0 $0
Thomas B Smith EVP and Chief Medical Officer Aug. 29, 2025 S 70,264 0 1 $-671,505
Scott Dreyer EVP & Chief Commercial Officer Aug. 18, 2025 M 103,613 0 1 $-626,224
David Dieter EVP & General Counsel March 17, 2025 A 68,449 0 0 $0
Shirley R. Kuhlmann EVP and General Counsel March 4, 2025 M 108,137 0 0 $0
Richard Malamut EVP and Chief Medical Officer Feb. 10, 2022 F 130,264 0 0 $0
Alison B Fleming EVP & Chief Technical Officer Aug. 10, 2021 F 143,694 0 0 $0
Gino Santini Director June 8, 2026 M 112,483 0 1 $-201,012
Rita J. Balice-Gordon Director May 15, 2025 A 56,279 0 0 $0
Carlos V Paya Director May 15, 2025 A 19,582 0 0 $0
John A. Fallon Director May 15, 2025 A 64,634 0 0 $0
Nancy Lurker Director May 15, 2025 A 22,517 0 0 $0
Michael Thomas Heffernan Director Feb. 10, 2025 A 50,328 0 0 $0
Neil F. Mcfarlane Director May 16, 2024 A 49,365 0 0 $0
Gwen A Melincoff Director May 16, 2024 A 52,468 0 0 $0
David Hirsch Director May 20, 2020 A 21,164 0 0 $0
Theodore R Schroeder Director May 20, 2020 A 11,007 0 0 $0
Eran Nadav Director June 9, 2016 A 0 0 $0
Patrick J. Heron Director Sept. 10, 2015 A 1,887,332 0 0 $0
Yasunori Kaneko 10% owner Dec. 5, 2017 J 270 0 0 $0
John Gordon Freund May 18, 2026 S 83,952 0 2 $-143,228
Garen G Bohlin May 14, 2026 A 71,000 0 1 $-323,466
Barry S Duke March 17, 2017 F 20,087 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Frazier Healthcare VI, L.P., FHM VI, L.P., FHM VI, L.L.C., James Topper, Patrick Heron, Alan Frazier, Nader Naini, Nathan Every ×3 filings Jan. 24, 2020 Initial filing SEC
Longitude Capital Partners, LLC, Longitude Capital Associates L.P., Longitude Venture Partners L.P., Juliet Tammenoms Bakker, Patrick G. Enright, David Hirsch May 21, 2015 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 84 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
ABLS · Abacus FCF ETF Trust 4.39% 1,598 NS April 30, 2026 N-PORT
PJP · Invesco Exchange-Traded Fund Trust 2.22% 381,066 SH Aug. 8, 2026 Daily
PBE · Invesco Exchange-Traded Fund Trust 2.09% 256,702 SH Aug. 8, 2026 Daily
PILL · Direxion Shares ETF Trust 1.27% 4,844 NS April 30, 2026 N-PORT
RNIN · EA Series Trust 1.17% 53,173 NS April 30, 2026 N-PORT
SIXS · EXCHANGE TRADED CONCEPTS TRUST 0.96% 36,323 NS May 31, 2026 N-PORT
CAFG · Pacer Funds Trust 0.82% 5,542 NS April 30, 2026 N-PORT
ROSC · Lattice Strategies Trust 0.73% 11,824 NS April 30, 2026 N-PORT
RZG · Invesco Exchange-Traded Fund Trust 0.67% 31,380 SH Aug. 8, 2026 Daily
SCOW · Pacer Funds Trust 0.65% 299 NS April 30, 2026 N-PORT
HAPS · Harbor ETF Trust 0.50% 23,380 NS April 30, 2026 N-PORT
PSCH · Invesco Exchange-Traded Fund Trust … 0.48% 28,148 SH Aug. 8, 2026 Daily
JSML · Janus Detroit Street Trust 0.48% 44,739 NS April 30, 2026 N-PORT
JSMD · Janus Detroit Street Trust 0.43% 124,586 NS April 30, 2026 N-PORT
SIXL · EXCHANGE TRADED CONCEPTS TRUST 0.39% 21,882 NS May 31, 2026 N-PORT
FYC · First Trust Exchange-Traded AlphaDE… 0.34% 103,935 NS April 30, 2026 N-PORT
CALF · Pacer Funds Trust 0.24% 249,657 NS April 30, 2026 N-PORT
BFOR · ALPS ETF Trust 0.23% 14,400 NS May 31, 2026 N-PORT
XSMO · Invesco Exchange-Traded Fund Trust 0.22% 232,940 SH Aug. 8, 2026 Daily
IWC · iShares Trust 0.22% 111,896 SH Aug. 8, 2026 Daily
ESSC · Strategy Shares 0.21% 1,602 NS April 30, 2026 N-PORT
IHE · iShares Trust 0.21% 115,713 SH Aug. 8, 2026 Daily
JPSE · J.P. Morgan Exchange-Traded Fund Tr… 0.21% 35,935 NS April 30, 2026 N-PORT
SMIZ · Zacks Trust 0.18% 13,598 NS May 31, 2026 N-PORT
VFMF · VANGUARD WELLINGTON FUND 0.14% 26,614 SH Aug. 8, 2026 Daily
VIOG · VANGUARD ADMIRAL FUNDS 0.13% 38,605 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.12% 36,154 NS May 31, 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0.12% 41,874 NS April 30, 2026 N-PORT
IJT · iShares Trust 0.10% 299,767 SH Aug. 8, 2026 Daily
SMMV · iShares Trust 0.09% 9,028 SH Aug. 8, 2026 Daily
SMDX · Tidal Trust III 0.09% 3,363 NS April 30, 2026 N-PORT
EBIT · Harbor ETF Trust 0.07% 251 NS April 30, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.07% 35,324 SH Aug. 8, 2026 Daily
FAD · First Trust Exchange-Traded AlphaDE… 0.07% 9,689 NS April 30, 2026 N-PORT
FSMD · FIDELITY COVINGTON TRUST 0.07% 47,796 NS April 30, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.07% 1,762 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.06% 50,340 NS May 31, 2026 N-PORT
VIOO · VANGUARD ADMIRAL FUNDS 0.06% 113,195 SH Aug. 8, 2026 Daily
XJR · iShares Trust 0.06% 3,837 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.06% 296,608 SH Aug. 8, 2026 Daily
QVMS · Invesco Exchange-Traded Fund Trust … 0.06% 4,873 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.05% 1,172 NS May 31, 2026 N-PORT
IJR · iShares Trust 0.05% 1,979,221 SH Aug. 8, 2026 Daily
SAA · ProShares Trust 0.05% 378 NS May 31, 2026 N-PORT
RWJ · Invesco Exchange-Traded Fund Trust … 0.04% 29,403 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.04% 40,335 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.04% 189,517 SH Aug. 8, 2026 Daily
AVUV · AMERICAN CENTURY ETF TRUST 0.04% 319,959 NS May 31, 2026 N-PORT
RSSL · Global X Funds 0.03% 13,639 NS April 30, 2026 N-PORT
FNDA · SCHWAB STRATEGIC TRUST 0.03% 84,924 NS May 31, 2026 N-PORT