OBIO Orchestra BioMed Holdings, Inc. - Ordinary Shares

NASDAQ · Health Care · View on SEC EDGAR ↗
$5.66
Price · Aug 19, 2026
Fundamentals as of Aug 10, 2026

OBIO Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$5.66
Market Cap
$323M
P/E (TTM)
-5.1
EPS (TTM)
$-1.11
Revenue (TTM)
$33M
Div Yield
ROE
-195.7%
Debt/Equity
52W Range
$2 – $6

OBIO Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $33M
4-point trend, +847.7%
2022-12-31 2025-12-31
EPS $-1.11
5-point trend, -5450.0%
2021-12-31 2025-12-31
Free Cash Flow $-49M
3-point trend, -7.0%
2023-12-31 2025-12-31
Margins -157.4%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
OBIO
Peer Median
P/E (TTM)
5-point trend, +99.3%
-5.1
27.5
P/S (TTM)
4-point trend, -43.8%
9.6
6.8
P/B
5-point trend, +138.8%
6.0
3.7
Price / FCF
3-point trend, +32.3%
-6.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
OBIO
Peer Median
Operating Margin
3-point trend, +91.7%
-154.7%
Net Profit Margin
3-point trend, +91.2%
-157.4%
-46.8%
ROA
5-point trend, -23891.3%
-55.2%
-31.4%
ROE
5-point trend, -2113.2%
-195.7%
-59.1%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
OBIO
Peer Median
Current Ratio
5-point trend, -40.7%
6.4
4.6
Quick Ratio
5-point trend, -39.9%
6.4

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
OBIO
Peer Median
Revenue YoY
4-point trend, +847.7%
1169.2%
Revenue CAGR 3Y
4-point trend, +847.7%
111.6%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
OBIO
Peer Median
EPS (Diluted)
5-point trend, -5450.0%
$-1.11

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
OBIO
Peer Median

OBIO Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 13 analysts
  • Strong Buy 3 23.1%
  • Buy 8 61.5%
  • Hold 2 15.4%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

6 analysts · 2026-08-15
Median target $10.00 +76.8%
Mean target $12.33 +118.1%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.07%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.38 $-0.40 0.02%
March 31, 2026 $-0.33 $-0.44 0.11%
Dec. 31, 2025 $-0.13 $-0.39 0.26%
Sept. 30, 2025 $-0.40 $-0.44 0.04%
June 30, 2025 $-0.50 $-0.51 0.01%
March 31, 2025 $-0.49 $-0.49 0.00%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
OBIO $237M -3.7 1169.2% -157.4% -195.7%
SI $295M -3.1 49.6% -85.3% -129.1% 76.5%
OFIX $604M -6.5 2.9% -11.2% -20.3% 68.8%
CARL $329M -5.8 85.9% -58.7% -375.2% 75.3%
MOBI
CV $501M -10.4 15.3% -186.8% 40.3% 52.9%
TMCI -2.6 1.6% -27.7% -63.8% 79.8%
ABT $250.18B 33.7 5.7% 14.7% 13.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for OBIO
Metric Trend 2025202420232022
Revenue 4-point trend, +847.7% $33M $3M $3M $4M
Cost of Revenue 4-point trend, -10.0% $190.0K $204.0K $186.0K $211.0K
R&D Expense 4-point trend, +165.1% $58M $43M $34M $22M
SG&A Expense 4-point trend, +91.8% $27M $24M $20M $14M
Operating Expenses 4-point trend, +135.7% $85M $67M $54M $36M
Operating Income 4-point trend, -58.6% $-52M $-64M $-52M $-33M
Interest Income · · · $345.1K
Other Non-op · $-11.0K · ·
Income Tax $0 · · ·
Net Income 4-point trend, -56.8% $-53M $-61M $-49M $-34M
EPS (Basic) 4-point trend, +50.4% $-1.11 $-1.66 $-1.48 $-2.24
EPS (Diluted) 4-point trend, +50.4% $-1.11 $-1.66 $-1.48 $-2.24
Shares (Basic) 4-point trend, +218.6% 47,747,078 36,821,042 33,225,227 14,988,584
Shares (Diluted) 4-point trend, +218.6% 47,747,078 36,821,042 33,225,227 14,988,584
EBITDA 4-point trend, -1571.3% $-51M $-64M $-51M $-3M
Balance Sheet 25
Annual Balance Sheet data for OBIO
Metric Trend 2025202420232022
Cash & Equivalents 4-point trend, +75.3% $35M $22M $31M $20M
Short-term Investments 4-point trend, +12.4% $72M $45M $57M $64M
Receivables 4-point trend, -1.0% $95.0K $92.0K $99.0K $96.0K
Inventory 4-point trend, +12.3% $310.0K $173.0K $146.0K $276.0K
Prepaid Expense 4-point trend, +86.5% $994.0K $2M $1M $533.0K
Current Assets 4-point trend, +27.4% $108M $69M $89M $85M
PP&E (Net) 4-point trend, +15.2% $2M $1M $1M $1M
PP&E (Gross) 4-point trend, +47.6% $3M $3M $2M $2M
Accum. Depreciation 4-point trend, +109.6% $2M $1M $1M $778.0K
Total Assets 4-point trend, +20.2% $115M $76M $95M $96M
Accounts Payable 4-point trend, +53.6% $6M $5M $3M $4M
Accrued Liabilities 4-point trend, +84.0% $10M $6M $5M $5M
Current Liabilities 4-point trend, -9.9% $17M $16M $11M $19M
Capital Leases 4-point trend, -44.4% $936.0K $2M $1M $2M
Deferred Tax 4-point trend, -38.3% $393.0K $561.0K $508.0K $637.0K
Other Non-current Liabilities 3-point trend, +57.1% $308.0K $40.0K · $196.0K
Total Liabilities 4-point trend, +19.6% $51M $43M $27M $43M
Long-term Debt Flat — no change across 2 periods $15M $15M · ·
Common Stock 4-point trend, +200.0% $6.0K $4.0K $4.0K $2.0K
Paid-in Capital 4-point trend, +64.9% $416M $343M $317M $252M
Retained Earnings 4-point trend, -81.5% $-363M $-310M $-249M $-200M
AOCI 4-point trend, +850.0% $60.0K $52.0K $-10.0K $-8.0K
Stockholders' Equity 4-point trend, +2.0% $54M $33M $68M $53M
Liabilities + Equity 4-point trend, +20.2% $115M $76M $95M $96M
Shares Outstanding 4-point trend, +182.5% 57,032,963 38,194,442 35,777,412 20,187,850
Cash Flow 10
Annual Cash Flow data for OBIO
Metric Trend 2025202420232022
D&A 4-point trend, +47.3% $327.0K $308.0K $287.0K $222.0K
Stock-based Comp 4-point trend, +254.9% $12M $11M $8M $3M
Other Non-cash 3-point trend, -74.2% $-9M $-457.0K $-5M ·
Operating Cash Flow 4-point trend, -67.2% $-49M $-51M $-46M $-29M
CapEx 4-point trend, -17.3% $489.0K $289.0K $78.0K $591.0K
Investing Cash Flow 4-point trend, +58.0% $-27M $13M $11M $-64M
Net Debt Issued · · $-11M ·
Financing Cash Flow 4-point trend, -14.5% $88M $29M $46M $103M
Net Change in Cash 4-point trend, +26.2% $12M $-8M $11M $10M
Free Cash Flow 3-point trend, -7.0% $-49M $-51M $-46M ·
Profitability 5
Annual Profitability data for OBIO
Metric Trend 2025202420232022
Operating Margin 3-point trend, +91.7% -154.7% -2437.5% -1866.2% ·
Net Margin 3-point trend, +91.2% -157.4% -2313.3% -1779.7% ·
EBITDA Margin 3-point trend, +91.7% -153.8% -2425.8% -1855.8% ·
ROA 4-point trend, -2218.5% -55.2% -71.2% -51.5% -2.4%
ROE 4-point trend, -1849.0% -195.7% -154.2% -66.5% -10.0%
Liquidity & Solvency 2
Annual Liquidity & Solvency data for OBIO
Metric Trend 2025202420232022
Current Ratio 4-point trend, +3659.7% 6.4 4.3 8.0 0.2
Quick Ratio 4-point trend, +6238.2% 6.4 4.1 7.8 0.1
Efficiency 3
Annual Efficiency data for OBIO
Metric Trend 2025202420232022
Asset Turnover 3-point trend, +1112.8% 0.4 0.0 0.0 ·
Inventory Turnover 3-point trend, -10.8% 0.8 1.3 0.9 ·
Receivables Turnover 3-point trend, +1165.0% 358.1 27.6 28.3 ·
Per Share 5
Annual Per Share data for OBIO
Metric Trend 2025202420232022
Book Value / Share 4-point trend, +160.2% $0.94 $0.86 $1.90 $-1.56
Revenue / Share 3-point trend, +743.8% $0.70 $0.07 $0.08 ·
Cash Flow / Share 4-point trend, -967.1% $-1.03 $-1.37 $-1.39 $-0.10
Cash / Share 4-point trend, +1443.7% $0.61 $0.58 $0.85 $0.04
EPS (TTM) 4-point trend, +50.4% $-1.11 $-1.66 $-1.48 $-2.24
Growth Rates 2
Annual Growth Rates data for OBIO
Metric Trend 2025202420232022
Revenue YoY 3-point trend, +5443.8% 1169.2% -4.4% -21.9% ·
Revenue CAGR 3Y 111.6% · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for OBIO
Metric Trend 2025202420232022
Revenue TTM 4-point trend, +847.7% $33M $3M $3M $4M
Net Income TTM 4-point trend, -56.8% $-53M $-61M $-49M $-34M
Market Cap 4-point trend, +432.9% $237M $153M $327M $44M
P/E 4-point trend, +16.1% -3.7 -2.4 -6.2 -4.5
P/S 4-point trend, -43.8% 7.1 57.9 118.4 12.6
P/B 4-point trend, +169.1% 4.4 4.6 4.8 -6.4
P / Tangible Book 4-point trend, +422.6% 4.4 4.6 4.8 0.8
P / Cash Flow 4-point trend, +82.8% -4.8 -3.0 -7.1 -28.1
P / FCF 3-point trend, +32.3% -4.8 -3.0 -7.1 ·
Earnings Yield 4-point trend, -19.2% -26.8% -41.5% -16.2% -22.4%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $33M$3M$3M$4M
Operating Margin % -154.7%-2437.5%-1866.2%
Net Income $-53M$-61M$-49M$-34M$-378.8K
Diluted EPS $-1.11$-1.66$-1.48$-2.24$-0.02
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 6.44.38.00.210.9
Quick Ratio 6.44.17.80.110.6
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-49M$-51M$-46M

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Institutional owners (13F) 86 filers · $108.0M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
29 (+13 vs prior Q) 13 (0 vs prior Q) 17 (-6 vs prior Q) 17 (+2 vs prior Q) +3.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
RTW INVESTMENTS, LP $41,234,412 9,556,063 38.19% Shares
PERCEPTIVE ADVISORS LLC $21,738,564 5,037,906 20.13% Shares
VANGUARD CAPITAL MANAGEMENT LLC $8,728,883 2,022,916 8.08% Shares
VANGUARD GROUP INC $5,688,272 1,370,668 5.27% Shares
Alyeska Investment Group, L.P. $4,315,000 1,000,000 4.00% Shares
Propel Bio Management, LLC $3,869,265 896,701 3.58% Shares
GEODE CAPITAL MANAGEMENT, LLC $3,696,819 856,460 3.42% Shares
STATE STREET CORP $2,226,756 516,050 2.06% Shares
RICE HALL JAMES & ASSOCIATES, LLC $1,829,560 424,000 1.69% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,508,282 349,544 1.40% Shares
VANGUARD FIDUCIARY TRUST CO $1,261,072 292,253 1.17% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $1,186,508 274,973 1.10% Shares
Knott David M Jr $1,094,504 253,651 1.01% Shares
Flat Footed LLC $1,084,670 251,372 1.00% Shares
Simplify Asset Management Inc. $946,655 219,387 0.88% Shares
DAFNA Capital Management LLC $547,319 126,841 0.51% Shares
AMH Equity Ltd $411,680 166,000 0.38% Shares
RENAISSANCE TECHNOLOGIES LLC $388,350 90,000 0.36% Shares
IFP Advisors, Inc $386,659 89,608 0.36% Shares
Daytona Street Capital LLC $379,336 96,398 0.35% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $347,789 80,600 0.32% Shares
GOLDMAN SACHS GROUP INC $323,875 75,058 0.30% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $283,944 65,804 0.26% Shares
CITADEL ADVISORS LLC $242,464 56,191 0.22% Shares
Nuveen, LLC $224,889 52,118 0.21% Shares
Holos Integrated Wealth LLC $204,316 51,595 0.19% Shares
Cubist Systematic Strategies, LLC $193,172 77,892 0.18% Shares
NewEdge Advisors, LLC $190,218 44,083 0.18% Shares
Y-Intercept (Hong Kong) Ltd $187,642 43,486 0.17% Shares
XTX Topco Ltd $167,482 38,814 0.16% Shares
WELLS FARGO & COMPANY/MN $156,876 36,356 0.15% Shares
HighTower Advisors, LLC $152,643 35,375 0.14% Shares
LASRY MARC $150,955 60,869 0.14% Shares
Affinity Asset Advisors, LLC $144,121 33,400 0.13% Shares
RHUMBLINE ADVISERS $137,813 31,940 0.13% Shares
ALGERT GLOBAL LLC $122,917 28,486 0.11% Shares
Meramec Financial Planners, LLC $114,600 30,000 0.11% Shares
TWO SIGMA ADVISERS, LP $112,465 27,100 0.10% Shares
AXQ CAPITAL, LP $109,808 25,448 0.10% Shares
MetLife Investment Management, LLC $103,534 23,994 0.10% Shares
BANK OF AMERICA CORP /DE/ $102,792 23,822 0.10% Shares
Bank of New York Mellon Corp $99,413 23,039 0.09% Shares
TWO SIGMA INVESTMENTS, LP $97,359 22,563 0.09% Shares
CANADA PENSION PLAN INVESTMENT BOARD $91,047 21,100 0.08% Shares
NEW YORK STATE COMMON RETIREMENT FUND $88,026 20,400 0.08% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $79,189 18,352 0.07% Shares
CITIGROUP INC $77,087 17,865 0.07% Shares
CITADEL ADVISORS LLC $75,944 17,600 0.07% Put option
UBS Group AG $75,884 17,586 0.07% Shares
Invesco Ltd. $68,578 15,893 0.06% Shares
JANE STREET GROUP, LLC $66,278 15,360 0.06% Shares
Vanguard Global Advisers, LLC $60,186 13,948 0.06% Shares
ABLE Financial Group, LLC $57,830 13,402 0.05% Shares
Sargent Investment Group, LLC $56,613 13,120 0.05% Shares
Frec Markets, Inc. $56,302 13,048 0.05% Shares
CITADEL ADVISORS LLC $52,212 12,100 0.05% Call option
Police & Firemen's Retirement System of New Jersey $50,723 11,755 0.05% Shares
BARCLAYS PLC $50,115 11,614 0.05% Shares
JANE STREET GROUP, LLC $49,191 11,400 0.05% Put option
Garden State Investment Advisory Services LLC $45,575 10,562 0.04% Shares
BlackRock, Inc. $45,191 10,473 0.04% Shares
MORGAN STANLEY $42,805 9,920 0.04% Shares
Nuveen Asset Management, LLC $41,160 10,290 0.04% Shares
China Universal Asset Management Co., Ltd. $41,122 9,530 0.04% Shares
BNP PARIBAS FINANCIAL MARKETS $35,443 8,214 0.03% Shares
NORTHERN TRUST CORP $27,163 6,295 0.03% Shares
Point72 Asia (Singapore) Pte. Ltd. $23,178 9,346 0.02% Shares
JPMORGAN CHASE & CO $20,701 4,358 0.02% Shares
Legal & General Group Plc $16,932 3,924 0.02% Shares
Ameritas Investment Partners, Inc. $15,607 3,617 0.01% Shares
Tower Research Capital LLC (TRC) $15,538 3,601 0.01% Shares
Russell Investments Group, Ltd. $13,751 3,187 0.01% Shares
Mirae Asset Global Investments Co., Ltd. $11,556 2,678 0.01% Shares
SIMPLEX TRADING, LLC $11,063 2,564 0.01% Shares
AdvisorNet Financial, Inc $7,318 1,696 0.01% Shares
ROYAL BANK OF CANADA $6,000 1,411 0.01% Shares
GF FUND MANAGEMENT CO. LTD. $5,062 1,173 0.00% Shares
JONES FINANCIAL COMPANIES LLLP $3,765 888 0.00% Shares
DEUTSCHE BANK AG\ $3,387 784 0.00% Shares
FMR LLC $682 158 0.00% Shares
Point72 (DIFC) Ltd $675 272 0.00% Shares
Sterling Capital Management LLC $604 140 0.00% Shares
Optiver Holding B.V. $173 40 0.00% Shares
PRICE T ROWE ASSOCIATES INC /MD/ $142 32,689 0.00% Shares
Caitong International Asset Management Co., Ltd $65 15 0.00% Shares
SBI Securities Co., Ltd. $26 6 0.00% Shares

Company insiders 20 insiders · 11 officers · 7 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
David P Hochman Chief Executive Officer and Chairperson June 10, 2026 F 436,199 5 0 $116,190
Roderick Wong, M.D. Chief Executive Officer Jan. 24, 2023 P 2,808,512 0 0 $0
Andrew Lawrence Taylor Chief Financial Officer June 10, 2026 F 593,065 1 0 $5,100
Michael Kaswan Chief Financial Officer Jan. 26, 2023 A 162,574 0 0 $0
Darren Sherman President and Chief Operating Officer Aug. 3, 2026 S 1,154,327 1 3 $-175,590
Joshua Aiello Principal Accounting Officer March 25, 2026 F 18,644 0 0 $0
William Reed Little Executive Vice President, Corporate Development & Strategy May 30, 2024 P 307,859 0 0 $0
George Papandreou General Manager and Senior Vice President, Focal Therapies May 8, 2024 A 42,000 0 0 $0
Yuval Mika General Manager and Chief Technology Officer, Bioelectronic Therapies May 8, 2024 A 158,905 0 0 $0
Stephanie A Sirota VP of Corp Stratege and Comm Aug. 4, 2020 P 20,000 0 0 $0
Alice Lee VP Operations, Sec & Treasurer Aug. 4, 2020 P 10,000 0 0 $0
Connealy Pamela Yanchik Director June 23, 2026 A 66,038 0 0 $0
Jason Aryeh Director June 23, 2026 A 118,118 3 0 $39,931
Eric A Rose MD Director June 20, 2024 A 7,544 0 0 $0
Geoffrey Wade Smith Director July 20, 2023 A 20,913 0 0 $0
HSAC 2 Holdings, LLC 10% owner Aug. 5, 2024 J 1,705,705 0 0 $0
Chris Cleary Aug. 12, 2026 F 29,153 0 0 $0
John Prosper Mack Aug. 12, 2026 F 66,544 0 0 $0
David Pacitti Aug. 12, 2026 F 54,750 0 0 $0
Eric S Fain Aug. 12, 2026 F 99,630 2 0 $97,634

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 3 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
RTW Investments, LP, RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd., Roderick Wong ×8 filings April 29, 2026 19.20% Amendment SEC
HSAC 2 Holdings, LLC ×3 filings Aug. 7, 2024 Initial filing SEC
Geoffrey W. Smith Feb. 7, 2023 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 13 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.04% 133,768 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.02% 3,230 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.01% 2,089 NS May 31, 2026 N-PORT
IWO · iShares Trust 0.01% 365,204 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 228,058 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.01% 42,916 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.00% 813,952 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.00% 178,322 NS May 31, 2026 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.00% 3,182 NS May 31, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 43,636 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 498,632 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 1,470,063 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 3,999 SH Aug. 8, 2026 Daily