UPB Upstream Bio, Inc. - Common Stock
$7.03
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026
52W Range
$6–$34
4% of range
Analyst Rating
BUY
13 analysts
Price Target
$38
+444% upside
P/E (TTM)
-2.6
ROE
-38.3%
Net Profit Margin
-5026.0%
UPB Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$7.03
Market Cap
$381M
P/E (TTM)
-2.6
EPS (TTM)
$-2.66
Revenue (TTM)
$3M
Div Yield
—
ROE
-38.3%
Debt/Equity
—
52W Range
$6 – $34
UPB Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
$3M
2023-12-31
→
2025-12-31
EPS
$-2.66
2023-12-31
→
2025-12-31
Free Cash Flow
$-133M
2024-12-31
→
2025-12-31
Margins
-5026.0%
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
UPB
Peer Median
P/E (TTM)
-2.6
4.6
P/S (TTM)
133.6
9.4
P/B
1.1
3.7
Price / FCF
-2.9
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
UPB
Peer Median
Operating Margin
-5618.8%
—
Net Profit Margin
-5026.0%
-186.4%
ROA
-34.3%
-48.0%
ROE
-38.3%
-67.6%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
UPB
Peer Median
Current Ratio
26.2
5.2
Quick Ratio
25.4
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
UPB
Peer Median
Revenue YoY
20.4%
—
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
UPB
Peer Median
UPB Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
13 analysts
- Strong Buy 2 15.4%
- Buy 8 61.5%
- Hold 3 23.1%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
8 analysts · 2026-08-13
Median
$39.50
← Below all targets
$7.03
Low
$8.00
High
$75.00
Median target
$39.50
+461.9%
Mean target
$38.25
+444.1%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
-0.18%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.75 | $-0.78 | 0.03% |
| Dec. 31, 2025 | $-0.79 | $-0.71 | -0.08% |
| Sept. 30, 2025 | $-0.63 | $-0.79 | 0.16% |
| June 30, 2025 | $-0.74 | $-0.62 | -0.12% |
| March 31, 2025 | $-0.51 | $-0.49 | -0.02% |
| Dec. 31, 2024 | $-1.59 | $-0.57 | -1.0% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| UPB | $1.47B | -10.2 | 20.4% | -5026.0% | -38.3% | — |
| FENC | $263M | -22.6 | -6.1% | -21.8% | -69.6% | — |
| LXEO | $725M | -5.3 | — | — | -51.9% | — |
| FHTX | $306M | -4.6 | 36.8% | -240.3% | 80.2% | — |
| XFOR | $364M | -2.1 | 150.0% | -1218.5% | -83.2% | — |
| PALI | $375M | -7.8 | — | — | -25.4% | — |
| RCKT | — | — | — | — | — | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 14
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $3M | $2M | $2M | |
| R&D Expense | $137M | $63M | $32M | |
| SG&A Expense | $26M | $17M | $11M | |
| Operating Expenses | $163M | $80M | $42M | |
| Operating Income | $-160M | $-78M | $-40M | |
| Interest Income | $17M | $12M | $4M | |
| Other Non-op | $17M | $15M | $20M | |
| Income Tax | $0 | $0 | $0 | |
| Net Income | $-143M | $-63M | $-21M | |
| EPS (Basic) | $-2.66 | $-5.58 | $-12.95 | |
| EPS (Diluted) | $-2.66 | $-5.58 | $-12.95 | |
| Shares (Basic) | 53,852,752 | 13,682,326 | 2,953,756 | |
| Shares (Diluted) | 53,852,752 | 13,682,326 | 2,953,756 | |
| EBITDA | $-160M | $-78M | · |
Balance Sheet 22
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $102M | $326M | $26M | |
| Short-term Investments | $240M | $145M | $84M | |
| Receivables | $668.0K | $613.0K | $98.0K | |
| Prepaid Expense | $10M | $8M | $7M | |
| Other Current Assets | $727.0K | · | · | |
| Current Assets | $352M | $479M | $117M | |
| PP&E (Net) | $559.0K | $582.0K | $159.0K | |
| PP&E (Gross) | $903.0K | $738.0K | $226.0K | |
| Accum. Depreciation | $344.0K | $156.0K | $67.0K | |
| Goodwill | · | $0 | · | |
| Total Assets | $354M | $482M | $117M | |
| Accounts Payable | $3M | $4M | $2M | |
| Current Liabilities | $13M | $11M | $7M | |
| Capital Leases | $549.0K | $1M | · | |
| Total Liabilities | $14M | $12M | $9M | |
| Common Stock | $54.0K | $53.0K | $3.0K | |
| Paid-in Capital | $673M | $661M | $5M | |
| Retained Earnings | $-334M | $-191M | $-128M | |
| AOCI | $530.0K | $-25.0K | $21.0K | |
| Stockholders' Equity | $340M | $470M | $-123M | |
| Liabilities + Equity | $354M | $482M | $117M | |
| Shares Outstanding | 54,237,750 | 53,603,398 | 2,992,479 |
Cash Flow 9
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $188.0K | $89.0K | $60.0K | |
| Stock-based Comp | $10M | $6M | $3M | |
| Other Non-cash | $-352.0K | $-2M | · | |
| Operating Cash Flow | $-133M | $-59M | $-38M | |
| CapEx | $165.0K | $511.0K | $144.0K | |
| Investing Cash Flow | $-93M | $-59M | $-83M | |
| Financing Cash Flow | $2M | $419M | $130M | |
| Net Change in Cash | $-224M | $300M | $9M | |
| Free Cash Flow | $-133M | $-60M | · |
Profitability 5
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -5618.8% | -3281.2% | · | |
| Net Margin | -5026.0% | -2650.0% | · | |
| EBITDA Margin | -5612.2% | -3277.4% | · | |
| ROA | -34.3% | -21.0% | · | |
| ROE | -38.3% | -40.6% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 26.2 | 44.6 | · | |
| Quick Ratio | 25.4 | 43.9 | · |
Efficiency 2
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | |
| Receivables Turnover | 4.5 | 6.7 | · |
Growth Rates 1
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 20.4% | -0.42% | · |
Valuation (TTM) 10
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $3M | $2M | · | |
| Net Income TTM | $-143M | $-63M | · | |
| Market Cap | $1.47B | $881M | · | |
| P/E | -10.2 | -2.9 | · | |
| P/S | 516.0 | 371.8 | · | |
| P/B | 4.3 | 1.9 | · | |
| P / Tangible Book | 4.3 | 1.9 | · | |
| P / Cash Flow | -11.0 | -14.9 | · | |
| P / FCF | -11.0 | -14.8 | · | |
| Earnings Yield | -9.8% | -33.9% | · |
Income Statement 14
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $773.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | $510.0K | $640.0K | $450.0K | |
| R&D Expense | $36M | $37M | $40M | $33M | $38M | $26M | $22M | $15M | $14M | $12M | $12M | |
| SG&A Expense | $7M | $8M | $7M | $6M | $7M | $7M | $5M | $4M | $4M | $4M | $3M | |
| Operating Expenses | $43M | $45M | $47M | $39M | $45M | $33M | $27M | $20M | $18M | $16M | $15M | |
| Operating Income | $-42M | $-44M | $-46M | $-38M | $-44M | $-32M | $-26M | $-19M | $-18M | $-15M | $-14M | |
| Interest Income | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $1M | $2M | |
| Other Non-op | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $4M | $2M | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-40M | $-41M | $-42M | $-34M | $-40M | $-27M | $-21M | $-16M | $-15M | $-11M | $-12M | |
| EPS (Basic) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| EPS (Diluted) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| Shares (Basic) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| Shares (Diluted) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| EBITDA | $-42M | $-44M | · | $-38M | $-44M | $-32M | · | $-19M | · | · | · |
Balance Sheet 21
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $79M | $97M | $102M | $72M | $45M | $71M | $326M | $33M | · | · | $26M | |
| Short-term Investments | $182M | $198M | $240M | $300M | $348M | $360M | $145M | $188M | · | · | $84M | |
| Receivables | $772.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | · | · | $98.0K | |
| Prepaid Expense | $18M | $21M | $10M | $16M | $24M | $22M | $8M | $6M | · | · | $7M | |
| Other Current Assets | $1M | · | · | · | · | · | · | · | · | · | · | |
| Current Assets | $280M | $316M | $352M | $389M | $418M | $454M | $479M | $227M | · | · | $117M | |
| PP&E (Net) | $460.0K | $510.0K | $559.0K | $616.0K | $544.0K | $539.0K | $582.0K | $578.0K | · | · | $159.0K | |
| PP&E (Gross) | $903.0K | $903.0K | $903.0K | $903.0K | $785.0K | $738.0K | $738.0K | $685.0K | · | · | $226.0K | |
| Accum. Depreciation | $443.0K | $393.0K | $344.0K | $287.0K | $241.0K | $199.0K | $156.0K | $107.0K | · | · | $67.0K | |
| Total Assets | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Accounts Payable | $2M | $2M | $3M | $4M | $3M | $5M | $4M | $5M | · | · | $2M | |
| Current Liabilities | $10M | $14M | $13M | $12M | $11M | $10M | $11M | $11M | · | · | $7M | |
| Capital Leases | $226.0K | $390.0K | $549.0K | $703.0K | $849.0K | $992.0K | $1M | $1M | · | · | · | |
| Total Liabilities | $10M | $14M | $14M | $13M | $12M | $11M | $12M | $12M | · | · | $9M | |
| Common Stock | $54.0K | $54.0K | $54.0K | $56.0K | $54.0K | $53.0K | $53.0K | $3.0K | · | · | $3.0K | |
| Paid-in Capital | $686M | $679M | $673M | $670M | $666M | $663M | $661M | $9M | · | · | $5M | |
| Retained Earnings | $-415M | $-375M | $-334M | $-292M | $-258M | $-218M | $-191M | $-170M | · | · | $-128M | |
| AOCI | $-123.0K | $100.0K | $530.0K | $493.0K | $258.0K | $368.0K | $-25.0K | $351.0K | · | · | $21.0K | |
| Stockholders' Equity | $271M | $304M | $340M | $379M | $409M | $446M | $470M | $-160M | · | · | $-123M | |
| Liabilities + Equity | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Shares Outstanding | 54,771,041 | 54,419,986 | 54,237,750 | 53,999,522 | 53,798,151 | 53,640,895 | 53,603,398 | 3,025,452 | · | · | 2,992,479 |
Cash Flow 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $50.0K | $49.0K | $57.0K | $46.0K | $42.0K | $43.0K | $49.0K | $14.0K | $13.0K | $13.0K | $14.0K | |
| Stock-based Comp | $4M | $5M | $3M | $3M | $3M | $3M | $2M | $2M | $1M | $643.0K | $711.0K | |
| Other Non-cash | · | $-12M | · | · | · | $-17M | · | · | · | · | · | |
| Operating Cash Flow | $-36M | $-48M | $-31M | $-22M | $-39M | $-41M | $-20M | $-14M | $-8M | $-18M | $-16M | |
| CapEx | · | · | $54.0K | $64.0K | · | · | $185.0K | · | · | · | $0 | |
| Investing Cash Flow | $16M | $42M | $59M | $48M | $13M | $-213M | $42M | $1M | $-117M | $14M | $-5M | |
| Financing Cash Flow | $3M | $598.0K | $1M | $760.0K | $612.0K | $-34.0K | $271M | $-2M | $141M | $9M | $-133.0K | |
| Net Change in Cash | $-17M | $-5M | $29M | $27M | $-26M | $-255M | $293M | $-14M | $16M | $6M | $-21M |
Profitability 5
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -5481.0% | -4218.1% | · | -5539.4% | -4732.9% | -5656.0% | · | -3112.5% | · | · | · | |
| Net Margin | -5136.1% | -3925.6% | · | -4941.1% | -4265.3% | -4818.0% | · | -2634.6% | · | · | · | |
| EBITDA Margin | -5481.0% | -4213.3% | · | -5539.4% | -4732.9% | -5648.4% | · | -3112.5% | · | · | · | |
| ROA | -11.3% | -10.5% | · | -10.8% | -19.0% | -12.0% | · | -13.7% | · | · | · | |
| ROE | -11.7% | -10.8% | · | -30.9% | -19.6% | -12.2% | · | 20.0% | · | · | · |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 28.0 | 23.1 | · | 32.7 | 38.3 | 47.4 | · | 20.9 | · | · | · | |
| Quick Ratio | 26.2 | 21.6 | · | 31.3 | 36.1 | 45.1 | · | 20.3 | · | · | · |
Efficiency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | · | · | · | |
| Receivables Turnover | 0.9 | 1.3 | · | 1.1 | 2.0 | 2.0 | · | 2.0 | · | · | · |
Valuation (TTM) 9
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $3M | $3M | · | $3M | $3M | $2M | · | $2M | · | · | · | |
| Net Income TTM | $-154M | $-142M | · | $-117M | $-98M | $-69M | · | $-45M | · | · | · | |
| Market Cap | $379M | $490M | · | $1.02B | $591M | $328M | · | · | · | · | · | |
| P/E | -2.4 | -3.4 | · | -2.1 | -0.7 | -0.3 | · | · | · | · | · | |
| P/S | 110.6 | 152.1 | · | 363.7 | 225.5 | 141.3 | · | · | · | · | · | |
| P/B | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Tangible Book | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Cash Flow | · | -10.2 | · | · | · | -8.0 | · | · | · | · | · | |
| Earnings Yield | -41.2% | -29.2% | · | -47.0% | -134.0% | -304.7% | · | · | · | · | · |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Revenue | $3M | $2M | $2M |
| Operating Margin % | -5618.8% | -3281.2% | — |
| Net Income | $-143M | $-63M | $-21M |
| Diluted EPS | $-2.66 | $-5.58 | $-12.95 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Current Ratio | 26.2 | 44.6 | — |
| Quick Ratio | 25.4 | 43.9 | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Free Cash Flow | $-133M | $-60M | — |
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Institutional owners (13F) 157 filers · $351.5M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 45 (+1 vs prior Q) | 25 (-11 vs prior Q) | 59 (+14 vs prior Q) | 30 (-4 vs prior Q) | +6.8M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| VANGUARD GROUP INC | $57,916,706 | 2,133,212 | 16.48% | Shares |
| FMR LLC | $50,318,247 | 7,271,423 | 14.31% | Shares |
| ORBIMED ADVISORS LLC | $39,399,636 | 5,693,589 | 11.21% | Shares |
| NORGES BANK | $26,078,843 | 3,768,619 | 7.42% | Shares |
| Decheng Capital LLC | $18,856,087 | 2,724,868 | 5.36% | Shares |
| ENAVATE SCIENCES GP, LLC | $17,021,145 | 2,459,703 | 4.84% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $12,986,999 | 1,876,734 | 3.69% | Shares |
| MILLENNIUM MANAGEMENT LLC | $7,914,923 | 1,143,775 | 2.25% | Shares |
| Qube Research & Technologies Ltd | $6,771,220 | 978,500 | 1.93% | Shares |
| Parkman Healthcare Partners LLC | $6,471,909 | 935,247 | 1.84% | Shares |
| SEB Asset Management AB | $6,079,022 | 878,473 | 1.73% | Shares |
| D. E. Shaw & Co., Inc. | $5,795,971 | 837,568 | 1.65% | Shares |
| Woodline Partners LP | $5,753,849 | 831,481 | 1.64% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $5,539,562 | 800,289 | 1.58% | Shares |
| STATE STREET CORP | $5,302,955 | 766,323 | 1.51% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4,931,656 | 712,667 | 1.40% | Shares |
| Y-Intercept (Hong Kong) Ltd | $4,799,401 | 693,555 | 1.37% | Shares |
| Bain Capital Life Sciences Investors, LLC | $4,158,567 | 600,949 | 1.18% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $3,539,898 | 511,546 | 1.01% | Shares |
| Walleye Capital LLC | $3,449,551 | 498,490 | 0.98% | Shares |
| Trexquant Investment LP | $3,227,696 | 466,430 | 0.92% | Shares |
| Point72 Asset Management, L.P. | $3,134,836 | 453,011 | 0.89% | Shares |
| BANK OF AMERICA CORP /DE/ | $2,710,993 | 391,762 | 0.77% | Shares |
| Altshuler Shaham Ltd | $2,630,022 | 380,061 | 0.75% | Shares |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2,475,672 | 357,756 | 0.70% | Shares |
| SAMSARA BIOCAPITAL, LLC | $2,447,722 | 353,717 | 0.70% | Shares |
| Propel Bio Management, LLC | $2,424,692 | 350,389 | 0.69% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $2,369,083 | 342,353 | 0.67% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $2,363,464 | 341,541 | 0.67% | Shares |
| Squarepoint Ops LLC | $2,013,056 | 290,904 | 0.57% | Shares |
| Voleon Capital Management LP | $1,973,819 | 285,234 | 0.56% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1,816,196 | 262,456 | 0.52% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1,751,397 | 253,092 | 0.50% | Shares |
| GOLDMAN SACHS GROUP INC | $1,708,666 | 246,917 | 0.49% | Shares |
| XTX Topco Ltd | $1,677,034 | 242,346 | 0.48% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $1,658,143 | 239,616 | 0.47% | Shares |
| UBS Group AG | $1,624,200 | 234,711 | 0.46% | Shares |
| Schonfeld Strategic Advisors LLC | $1,562,258 | 225,760 | 0.44% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $1,520,324 | 219,700 | 0.43% | Shares |
| BlackRock, Inc. | $1,054,823 | 152,431 | 0.30% | Shares |
| Boxer Capital Management, LLC | $1,038,000 | 150,000 | 0.30% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $908,596 | 131,300 | 0.26% | Shares |
| EntryPoint Capital, LLC | $895,766 | 129,446 | 0.25% | Shares |
| ALGERT GLOBAL LLC | $820,920 | 118,630 | 0.23% | Shares |
| AMERICAN CENTURY COMPANIES INC | $541,102 | 78,194 | 0.15% | Shares |
| Man Group plc | $510,855 | 73,823 | 0.15% | Shares |
| JPMORGAN CHASE & CO | $505,093 | 72,885 | 0.14% | Shares |
| ALLIANCEBERNSTEIN L.P. | $465,120 | 51,680 | 0.13% | Shares |
| Simplify Asset Management Inc. | $429,822 | 62,113 | 0.12% | Shares |
| ALPS ADVISORS INC | $382,178 | 55,228 | 0.11% | Shares |
| Quantinno Capital Management LP | $379,479 | 54,838 | 0.11% | Shares |
| Nuveen Asset Management, LLC | $371,314 | 22,586 | 0.11% | Shares |
| Virtus Investment Advisers, LLC | $371,175 | 53,638 | 0.11% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $356,949 | 39,661 | 0.10% | Shares |
| Brevan Howard Capital Management LP | $348,553 | 50,369 | 0.10% | Shares |
| Swiss National Bank | $332,852 | 48,100 | 0.09% | Shares |
| MORGAN STANLEY | $311,220 | 44,974 | 0.09% | Shares |
| Allspring Global Investments Holdings, LLC | $298,819 | 43,182 | 0.09% | Shares |
| RHUMBLINE ADVISERS | $293,288 | 42,384 | 0.08% | Shares |
| TWO SIGMA INVESTMENTS, LP | $292,889 | 42,325 | 0.08% | Shares |
| ExodusPoint Capital Management, LP | $284,031 | 41,045 | 0.08% | Shares |
| CITIGROUP INC | $265,084 | 38,307 | 0.08% | Shares |
| Stonepine Capital Management, LLC | $231,349 | 33,432 | 0.07% | Shares |
| Mariner, LLC | $229,337 | 33,141 | 0.07% | Shares |
| DEUTSCHE BANK AG\ | $228,561 | 33,029 | 0.07% | Shares |
| WELLS FARGO & COMPANY/MN | $204,119 | 29,497 | 0.06% | Shares |
| Bank of New York Mellon Corp | $197,711 | 28,571 | 0.06% | Shares |
| Quantbot Technologies LP | $194,992 | 28,178 | 0.06% | Shares |
| BARCLAYS PLC | $193,608 | 27,978 | 0.06% | Shares |
| AXQ CAPITAL, LP | $187,311 | 27,068 | 0.05% | Shares |
| nVerses Capital, LLC | $166,280 | 24,029 | 0.05% | Shares |
| DNB Asset Management AS | $163,312 | 23,600 | 0.05% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $157,250 | 22,724 | 0.04% | Shares |
| Graham Capital Management, L.P. | $155,755 | 22,508 | 0.04% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154,904 | 22,385 | 0.04% | Shares |
| Verdad Advisers, LP | $150,925 | 21,810 | 0.04% | Shares |
| MetLife Investment Management, LLC | $144,296 | 20,852 | 0.04% | Shares |
| SEI INVESTMENTS CO | $138,580 | 20,026 | 0.04% | Shares |
| WINTON GROUP Ltd | $137,016 | 19,800 | 0.04% | Shares |
| IEQ CAPITAL, LLC | $135,182 | 19,535 | 0.04% | Shares |
| DIADEMA PARTNERS LP | $132,124 | 19,093 | 0.04% | Shares |
| Shay Capital LLC | $124,560 | 18,000 | 0.04% | Shares |
| Quadrature Capital Ltd | $124,477 | 17,988 | 0.04% | Shares |
| Entropy Technologies, LP | $121,391 | 17,542 | 0.03% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $118,090 | 17,065 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112,222 | 16,217 | 0.03% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108,886 | 15,735 | 0.03% | Shares |
| CITADEL ADVISORS LLC | $103,800 | 15,000 | 0.03% | Call option |
| MERCER GLOBAL ADVISORS INC /ADV | $92,396 | 13,352 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $90,368 | 13,059 | 0.03% | Shares |
| Engineers Gate Manager LP | $86,438 | 12,491 | 0.02% | Shares |
| Invesco Ltd. | $84,611 | 12,227 | 0.02% | Shares |
| STRS OHIO | $83,040 | 12,000 | 0.02% | Shares |
| JANE STREET GROUP, LLC | $82,348 | 11,900 | 0.02% | Call option |
| CANADA PENSION PLAN INVESTMENT BOARD | $79,580 | 11,500 | 0.02% | Shares |
| HSBC HOLDINGS PLC | $77,602 | 10,793 | 0.02% | Shares |
| JANE STREET GROUP, LLC | $77,324 | 11,174 | 0.02% | Shares |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $75,428 | 10,017 | 0.02% | Shares |
| PRELUDE CAPITAL MANAGEMENT, LLC | $73,006 | 10,550 | 0.02% | Shares |
| AMERIPRISE FINANCIAL INC | $72,570 | 10,487 | 0.02% | Shares |
Company insiders 12 insiders · 5 officers · 7 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Everett Rand Sutherland | Chief Executive Officer | June 16, 2026 S | 70,812 | 0 | 2 | $-32,224 |
| Michael Gray | CFO and COO | June 16, 2026 S | 28,795 | 0 | 2 | $-13,118 |
| Allison Ambrose | General Counsel | June 16, 2026 S | 16,048 | 0 | 2 | $-7,323 |
| Aaron Deykin | Chief Medical Officer | June 16, 2026 S | 33,197 | 0 | 2 | $-13,765 |
| Adam Houghton | Chief Business Officer | June 16, 2026 S | 23,601 | 0 | 2 | $-10,764 |
| Marcella K. Ruddy | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Harold Edward Fleming | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| CHIMOVITS EREZ | Director | June 9, 2026 A | 4,554,873 | 0 | 0 | $0 |
| Liam Ratcliffe | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Daniella Beckman | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Ronald C Renaud JR | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | 10% owner | Oct. 15, 2024 C | 894,733 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 2 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| AI Upstream LLC, Access Industries Holdings LLC, AI Biotechnology LLC, Access Industries Management, LLC, Len Blavatnik | Oct. 22, 2024 | — | Initial filing | Passive investment | SEC |
| OrbiMed Advisors LLC, OrbiMed Capital GP VIII LLC, OrbiMed Advisors Israel II Limited, OrbiMed Israel GP II, L.P. | Oct. 17, 2024 | — | Initial filing | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 32 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| FMED · Fidelity Covington Trust | 0.51% | 24,900 NS | May 31, 2026 | N-PORT |
| SBIO · ALPS ETF Trust | 0.29% | 55,699 NS | May 31, 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0.25% | 10,169 NS | April 30, 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0.07% | 92,201 NS | April 30, 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.03% | 2,927 SH | Aug. 8, 2026 | Daily |
| BIB · ProShares Trust | 0.02% | 1,997 NS | May 31, 2026 | N-PORT |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0.02% | 31,318 SH | Aug. 8, 2026 | Daily |
| IBB · iShares Trust | 0.02% | 264,706 SH | Aug. 8, 2026 | Daily |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.02% | 62,606 NS | May 31, 2026 | N-PORT |
| IWN · iShares Trust | 0.02% | 334,907 SH | Aug. 8, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.01% | 202,528 SH | Aug. 8, 2026 | Daily |
| RSSL · Global X Funds | 0.01% | 14,420 NS | April 30, 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.01% | 33,677 SH | Aug. 8, 2026 | Daily |
| IWM · iShares Trust | 0.01% | 902,359 SH | Aug. 8, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.01% | 108,557 NS | April 30, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.01% | 1,544 NS | May 31, 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.01% | 161,663 NS | May 31, 2026 | N-PORT |
| UWM · ProShares Trust | 0.00% | 1,208 NS | May 31, 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0.00% | 11,160 NS | April 30, 2026 | N-PORT |
| URTY · ProShares Trust | 0.00% | 1,224 NS | May 31, 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 1,388 NS | May 31, 2026 | N-PORT |
| HDG · ProShares Trust | 0.00% | 31 NS | May 31, 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 10,145 NS | April 30, 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 2,366 NS | April 30, 2026 | N-PORT |
| ITOT · iShares Trust | 0.00% | 49,987 SH | Aug. 8, 2026 | Daily |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 20,416 NS | May 31, 2026 | N-PORT |
| IWV · iShares Trust | 0.00% | 9,569 SH | Aug. 8, 2026 | Daily |
| AVSU · AMERICAN CENTURY ETF TRUST | 0.00% | 34 NS | May 31, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.00% | 386,877 SH | Aug. 8, 2026 | Daily |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,443,025 SH | Aug. 8, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 2,529 SH | Aug. 8, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | 0.00% | 72,742 SH | Aug. 8, 2026 | Daily |