WHWK Whitehawk Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$4.88
Price · Aug 19, 2026
Fundamentals as of Aug 6, 2026

WHWK Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$4.88
Market Cap
$230M
P/E (TTM)
-14.8
EPS (TTM)
$-0.33
Revenue (TTM)
$7M
Div Yield
ROE
-13.4%
Debt/Equity
52W Range
$2 – $5

WHWK Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $7M
8-point trend, -64.6%
2018-12-31 2025-12-31
EPS $-0.33
5-point trend, +97.3%
2021-12-31 2025-12-31
Free Cash Flow $-98M
8-point trend, -1576.1%
2018-12-31 2025-12-31
Margins -288.3%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
WHWK
Peer Median
P/E (TTM)
5-point trend, -276.8%
-14.8
1.2
P/S (TTM)
5-point trend, -55.7%
32.2
6.3
P/B
5-point trend, -77.4%
1.7
1.6
Price / FCF
5-point trend, +94.8%
-2.4

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
WHWK
Peer Median
Operating Margin
5-point trend, +83.9%
-1601.1%
Net Profit Margin
5-point trend, +97.1%
-288.3%
-312.6%
ROA
5-point trend, +85.0%
-18.6%
-56.8%
ROE
5-point trend, +82.6%
-13.4%
-83.3%
ROIC
5-point trend, -2.9%
-83.9%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
WHWK
Peer Median
Current Ratio
5-point trend, +3.6%
10.3
8.5
Quick Ratio
5-point trend, +2.9%
10.0

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
WHWK
Peer Median
Revenue YoY
5-point trend, -49.0%
-72.5%
Revenue CAGR 3Y
5-point trend, -49.0%
-22.3%
Revenue CAGR 5Y
5-point trend, -49.0%
-12.6%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
WHWK
Peer Median
EPS (Diluted)
5-point trend, +97.3%
$-0.33

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
WHWK
Peer Median

WHWK Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 14 analysts
  • Strong Buy 4 28.6%
  • Buy 6 42.9%
  • Hold 4 28.6%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

6 analysts · 2026-08-15
Median target $7.50 +53.7%
Mean target $7.50 +53.7%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.25%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.20 $-0.30 0.10%
March 31, 2026 $-0.32 $-0.36 0.04%
Dec. 31, 2025 $-0.34 $-0.16 -0.18%
Sept. 30, 2025 $-0.26 $0.07 -0.33%
June 30, 2025 $-0.76 $0.50 -1.3%
March 31, 2025 $-0.37 $-0.47 0.10%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
WHWK $114M -7.3 -72.5% -288.3% -13.4%
RNA $10.91B -14.5 72.1% -3650.4% -47.5%
NERV $174M -0.1 339.5%
IVVD $697M -8.2 110.5% -98.2% -36.9%
TNXP $200M -1.1 29.8% -946.2% -60.0%
PEPG $448M -3.1 -82.0%
KROS $398M 8.9 35.7% 17.2%
DTIL $100M -1.2 -50.1% -133.4% -72.4%
CRBP $143M -1.4 -60.8%
KRRO $75M -0.6 181.5% -1834.5% -140.8%
ABOS $128M -1.1 -129.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for WHWK
Metric Trend 20252024202320222021202020192018
Revenue 8-point trend, -64.6% $7M $26M $24M $15M $14M $14M $0 $20M
Cost of Revenue 5-point trend, +760000.00 $760.0K $3M $3M $1M $0 · · ·
R&D Expense 8-point trend, +409.5% $91M $51M $49M $33M $20M $15M $13M $18M
SG&A Expense 8-point trend, +121.1% $30M $37M $45M $40M $19M $2M $10M $13M
Operating Expenses 8-point trend, +287.8% $122M $93M $96M $78M $112M $17M $24M $31M
Operating Income 8-point trend, -923.1% $-114M $-67M $-72M $-63M $-111M $-3M $-24M $-11M
Interest Expense 4-point trend, -71.7% · · $231.0K $230.0K $665.0K $815.0K · ·
Interest Income 6-point trend, +15097.6% $6M $4M $6M $2M $13.0K $41.0K · ·
Other Non-op 8-point trend, +11855.5% $94M $4M $6M $2M $1M $-927.0K $1M $784.6K
Pretax Income 6-point trend, -492.5% $-21M $-64M $-66M $-61M $-110M $-3M · ·
Income Tax 6-point trend, -100.0% $0 $0 $0 $0 $2.0K $2.0K · ·
Net Income 8-point trend, -98.1% $-21M $-64M $-66M $-61M $-110M $-3M $-23M $-10M
EPS (Basic) 5-point trend, +97.3% $-0.33 $-2.36 $-2.44 $-2.69 $-12.41 · · ·
EPS (Diluted) 5-point trend, +97.3% $-0.33 $-2.36 $-2.44 $-2.69 $-12.41 · · ·
Shares (Basic) 5-point trend, +593.5% 61,886,765 27,029,942 26,917,967 22,511,237 8,923,369 · · ·
Shares (Diluted) 5-point trend, +593.5% 61,886,765 27,029,942 26,917,967 22,511,237 8,923,369 · · ·
EBITDA 8-point trend, -922.4% $-114M $-67M $-72M $-63M $-111M $-6M $-24M $-11M
Balance Sheet 25
Annual Balance Sheet data for WHWK
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, -40.0% $38M $29M $63M $39M $149M $4M $39M $63M
Short-term Investments 5-point trend, +108129000.00 $108M $19M $46M $134M $0 · · ·
Receivables 6-point trend, -100.0% $0 $6M $5M $2M $0 $14M · ·
Inventory 5-point trend, +0.00 $0 $5M $6M $2M $0 · · ·
Prepaid Expense 8-point trend, +339.6% $3M $3M $4M $4M $2M $81.0K $311.2K $754.4K
Other Current Assets 3-point trend, +160.5% · · · · · $2M $734.8K $615.7K
Current Assets 8-point trend, +132.9% $149M $61M $125M $180M $151M $19M $40M $64M
PP&E (Net) 8-point trend, -97.0% $3.0K $7M $5M $508.0K $57.0K $21.0K $164.2K $98.4K
PP&E (Gross) 8-point trend, -8.0% $377.0K $7M $5M $609.0K $87.0K $512.1K $493.0K $409.6K
Accum. Depreciation 8-point trend, +20.2% $374.0K $463.0K $270.0K $101.0K $30.0K $390.3K $328.9K $311.1K
Intangibles 2-point trend, -100.0% · · · $0 $4M · · ·
Other Non-current Assets 5-point trend, -18.0% $2M $1M $2M $2M $2M · · ·
Total Assets 8-point trend, +135.2% $151M $70M $132M $184M $158M $19M $40M $64M
Accounts Payable 8-point trend, +53.9% $917.0K $2M $6M $4M $6M $2M $439.8K $595.7K
Accrued Liabilities 6-point trend, +231.8% $14M $15M $14M $15M $9M $4M · ·
Current Liabilities 8-point trend, +166.1% $15M $17M $26M $19M $15M $30M $3M $5M
Capital Leases 6-point trend, -100.0% $0 $565.0K $833.0K $1M $474.0K · $67.4K ·
Other Non-current Liabilities 5-point trend, -100.0% $0 $202.0K $0 · $0 $97.0K · ·
Total Liabilities 8-point trend, +166.1% $15M $18M $27M $26M $22M $31M $3M $5M
Common Stock 8-point trend, -1.5% $4.0K $2.0K $2.0K $2.0K $2.0K $1.0K $4.1K $4.1K
Retained Earnings 8-point trend, -197.0% $-353M $-333M $-269M $-203M $-143M $-33M $-142M $-119M
AOCI 5-point trend, +120000.00 $120.0K $16.0K $27.0K $-115.0K $0 · · ·
Stockholders' Equity 8-point trend, +132.3% $136M $52M $105M $158M $136M $-12M $-9M $59M
Liabilities + Equity 8-point trend, +135.2% $151M $70M $132M $184M $158M $19M $40M $64M
Shares Outstanding 8-point trend, +16.2% 47,145,719 24,681,000 24,554,000 24,435,000 20,895,000 2,542,358 40,588,004 40,588,004
Cash Flow 16
Annual Cash Flow data for WHWK
Metric Trend 20252024202320222021202020192018
D&A 6-point trend, +777.8% $79.0K $193.0K $169.0K $159.0K $105.0K $9.0K · ·
Stock-based Comp 8-point trend, +187.7% $10M $11M $12M $10M $2M $139.0K $1M $3M
Deferred Tax Flat — no change across 4 periods · · · · $0 $0 $0 $0
Amort. of Intangibles 4-point trend, +0.00 · · $0 $87.0K $95.0K $0 · ·
Restructuring 3-point trend, +0.00 $0 $3M $0 · · · · ·
Other Non-cash 5-point trend, -201.6% $-87M $-7M $-6M $1M $85M · · ·
Operating Cash Flow 8-point trend, -1577.6% $-97M $-60M $-60M $-50M $-22M $-13M $-24M $-6M
CapEx 8-point trend, +1356.0% $552.0K $2M $4M $444.0K $46.0K $19.0K $237.0K $37.9K
Investing Cash Flow 8-point trend, +31464.7% $12M $25M $83M $-133M $25M $-19.0K $-237.0K $-37.9K
Stock Issued 4-point trend, -100.0% · · · $0 $155M $10M · $52M
Net Stock Activity 4-point trend, -100.0% · · · $0 $155M $10M · $52M
Dividends Paid 2-point trend, -100.0% · · · $0 $4M · · ·
Financing Cash Flow 7-point trend, +95.8% $94M $130.0K $326.0K $73M $142M $1M · $48M
Net Change in Cash 8-point trend, -79.1% $9M $-34M $24M $-110M $145M $-12M $-24M $42M
Free Cash Flow 8-point trend, -1576.1% $-98M $-61M $-64M $-50M $-22M $-5M $-24M $-6M
Levered FCF 3-point trend, -176.1% · · $-64M $-50M $-23M · · ·
Profitability 7
Annual Profitability data for WHWK
Metric Trend 20252024202320222021202020192018
Operating Margin 7-point trend, -2786.5% -1601.1% -259.6% -295.4% -411.9% -9930.1% -42.4% · -55.5%
Net Margin 7-point trend, -458.9% -288.3% -245.1% -270.0% -397.7% -9829.5% -28.8% · -51.6%
Pretax Margin 5-point trend, +97.1% -288.3% -245.1% -270.0% -397.7% -9829.3% · · ·
EBITDA Margin 7-point trend, -2784.5% -1600.0% -258.9% -294.7% -410.9% -9920.7% -42.4% · -55.5%
ROA 8-point trend, +23.7% -18.6% -62.8% -41.5% -35.4% -124.6% -10.2% -44.7% -24.4%
ROE 8-point trend, +19.6% -13.4% -105.0% -58.9% -37.0% -76.6% -38.2% -59.5% -16.6%
ROIC 5-point trend, -2.9% -83.9% -128.6% -68.4% -39.6% -81.5% · · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for WHWK
Metric Trend 20252024202320222021202020192018
Current Ratio 8-point trend, -12.5% 10.3 3.6 4.7 9.6 9.9 24.0 11.9 11.7
Quick Ratio 8-point trend, -12.5% 10.0 3.1 4.3 9.3 9.8 22.8 11.6 11.5
Interest Coverage 3-point trend, -86.2% · · -311.4 -272.5 -167.2 · · ·
Efficiency 3
Annual Efficiency data for WHWK
Metric Trend 20252024202320222021202020192018
Asset Turnover 7-point trend, -86.4% 0.1 0.3 0.2 0.1 0.0 0.4 · 0.5
Inventory Turnover 4-point trend, -80.1% 0.3 0.5 0.7 1.4 · · · ·
Receivables Turnover 4-point trend, -85.2% 2.4 4.6 6.6 16.3 · · · ·
Per Share 5
Annual Per Share data for WHWK
Metric Trend 20252024202320222021202020192018
Book Value / Share 8-point trend, +100.0% $2.89 $2.13 $4.28 $6.48 $6.53 $0.91 $0.90 $1.45
Revenue / Share 4-point trend, -82.9% $0.12 $0.96 $0.90 $0.68 · · · ·
Cash Flow / Share 4-point trend, +28.6% $-1.57 $-2.20 $-2.22 $-2.21 · · · ·
Cash / Share 8-point trend, -48.4% $0.80 $1.16 $2.56 $1.60 $7.13 $0.90 $0.95 $1.54
EPS (TTM) 5-point trend, +97.3% $-0.33 $-2.36 $-2.44 $-2.69 $-12.41 · · ·
Growth Rates 3
Annual Growth Rates data for WHWK
Metric Trend 20252024202320222021202020192018
Revenue YoY 5-point trend, -0.72 -72.5% 6.7% 60.1% 8.7% 0.00% · · ·
Revenue CAGR 3Y 3-point trend, -209.9% -22.3% 22.9% 20.3% · · · · ·
Revenue CAGR 5Y -12.6% · · · · · · ·
Valuation (TTM) 13
Annual Valuation (TTM) data for WHWK
Metric Trend 20252024202320222021202020192018
Revenue TTM 8-point trend, -64.6% $7M $26M $24M $15M $14M $14M $0 $20M
Net Income TTM 8-point trend, -98.1% $-21M $-64M $-66M $-61M $-110M $-3M $-23M $-10M
Market Cap 8-point trend, -89.0% $114M $78M $50M $314M $505M $695M $380M $1.03B
P/E 5-point trend, -276.8% -7.3 -1.3 -0.8 -4.8 -1.9 · · ·
P/S 7-point trend, -68.9% 16.0 3.0 2.0 20.6 36.0 49.6 · 51.3
P/B 8-point trend, -95.3% 0.8 1.5 0.5 2.0 3.7 16.1 10.4 17.6
P / Tangible Book 5-point trend, -78.0% 0.8 1.5 0.5 2.0 3.8 · · ·
P / Cash Flow 8-point trend, +99.3% -1.2 -1.3 -0.8 -6.3 -22.5 -129.0 -15.9 -178.2
P / FCF 8-point trend, +99.3% -1.2 -1.3 -0.8 -6.3 -22.5 -128.5 -15.8 -177.0
Dividend Yield 2-point trend, -100.0% · · · 0.00% 0.87% · · ·
Earnings Yield 5-point trend, +73.5% -13.6% -74.8% -120.8% -21.0% -51.4% · · ·
Payout Ratio 2-point trend, +100.0% · · · 0.00% -4.0% · · ·
Annual Payout 2-point trend, -100.0% · · · $0 $4M · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $7M$26M$24M$15M$14M
Operating Margin % -1601.1%-259.6%-295.4%-411.9%-9930.1%
Net Income $-21M$-64M$-66M$-61M$-110M
Diluted EPS $-0.33$-2.36$-2.44$-2.69$-12.41
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 10.33.64.79.69.9
Quick Ratio 10.03.14.39.39.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-98M$-61M$-64M$-50M$-22M

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Institutional owners (13F) 84 filers · $187.5M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
32 (+13 vs prior Q) 11 (+7 vs prior Q) 25 (+11 vs prior Q) 12 (+4 vs prior Q) +8.5M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Yu Fan $22,264,818 4,861,314 11.87% Shares
ACUTA CAPITAL PARTNERS, LLC $21,461,477 4,685,912 11.44% Shares
QVT Financial LP $21,139,947 4,615,709 11.27% Shares
MONTANOVA CAPITAL, LLC $19,694,000 4,300,000 10.50% Shares
ORBIMED ADVISORS LLC $18,019,076 3,934,296 9.61% Shares
Avoro Capital Advisors LLC $13,050,261 2,849,402 6.96% Shares
Siren, L.L.C. $10,703,927 2,337,102 5.71% Shares
KVP Capital Advisors, LP $9,920,266 2,165,997 5.29% Shares
VANGUARD CAPITAL MANAGEMENT LLC $6,359,609 1,388,561 3.39% Shares
ADAR1 Capital Management, LLC $6,143,585 1,341,394 3.28% Shares
ACORN CAPITAL ADVISORS, LLC $5,218,283 1,139,363 2.78% Shares
STEMPOINT CAPITAL LP $4,676,349 1,021,037 2.49% Shares
Ally Bridge Group (NY) LLC $3,746,161 817,939 2.00% Shares
GEODE CAPITAL MANAGEMENT, LLC $3,495,462 762,997 1.86% Shares
Woodline Partners LP $1,999,692 436,614 1.07% Shares
RENAISSANCE TECHNOLOGIES LLC $1,895,305 413,822 1.01% Shares
STATE STREET CORP $1,772,378 386,982 0.95% Shares
MILLENNIUM MANAGEMENT LLC $1,742,259 380,406 0.93% Shares
Eversept Partners, LP $1,389,141 303,306 0.74% Shares
Verdad Advisers, LP $1,380,792 301,483 0.74% Shares
TWO SIGMA INVESTMENTS, LP $1,358,483 296,612 0.72% Shares
AMES NATIONAL CORP $1,333,269 4,571 0.71% Shares
Balyasny Asset Management L.P. $1,319,576 288,117 0.70% Shares
VANGUARD FIDUCIARY TRUST CO $1,130,834 246,907 0.60% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $1,004,014 219,217 0.54% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $757,001 165,284 0.40% Shares
VANGUARD GROUP INC $519,881 214,827 0.28% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $361,051 78,832 0.19% Shares
GOLDMAN SACHS GROUP INC $349,060 76,214 0.19% Shares
Point72 Asset Management, L.P. $261,651 57,129 0.14% Shares
AMERICAN CENTURY COMPANIES INC $237,427 51,840 0.13% Shares
Qube Research & Technologies Ltd $224,388 48,993 0.12% Shares
UBS Group AG $210,098 45,873 0.11% Shares
Nuveen, LLC $200,599 43,799 0.11% Shares
Jump Financial, LLC $186,864 40,800 0.10% Shares
DEUTSCHE BANK AG\ $145,039 31,668 0.08% Shares
Bank of New York Mellon Corp $132,623 28,957 0.07% Shares
WELLS FARGO & COMPANY/MN $124,457 27,174 0.07% Shares
DIMENSIONAL FUND ADVISORS LP $123,761 27,022 0.07% Shares
RHUMBLINE ADVISERS $112,338 24,529 0.06% Shares
Y-Intercept (Hong Kong) Ltd $111,583 24,363 0.06% Shares
TWO SIGMA ADVISERS, LP $102,608 42,400 0.05% Shares
Vanguard Global Advisers, LLC $89,205 19,477 0.05% Shares
NEW YORK STATE COMMON RETIREMENT FUND $85,646 18,700 0.05% Shares
BANK OF AMERICA CORP /DE/ $85,518 18,672 0.05% Shares
XTX Topco Ltd $84,831 18,522 0.05% Shares
CITADEL ADVISORS LLC $79,440 17,345 0.04% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $68,434 14,942 0.04% Shares
ABG Innovation Capital Partners III GP Ltd $64,532 26,666 0.03% Shares
CITIGROUP INC $60,209 13,146 0.03% Shares
JPMORGAN CHASE & CO $59,323 13,452 0.03% Shares
Invesco Ltd. $59,261 12,939 0.03% Shares
EVERGREEN CAPITAL MANAGEMENT LLC $50,380 11,000 0.03% Shares
Scientech Research LLC $49,638 10,838 0.03% Shares
Police & Firemen's Retirement System of New Jersey $46,739 10,205 0.02% Shares
Quadrature Capital Ltd $46,002 10,044 0.02% Shares
TWO SIGMA SECURITIES, LLC $45,951 10,033 0.02% Shares
BNP PARIBAS FINANCIAL MARKETS $31,804 6,944 0.02% Shares
NORTHERN TRUST CORP $23,239 5,074 0.01% Shares
BARCLAYS PLC $22,182 4,843 0.01% Shares
US BANCORP \DE\ $15,265 3,333 0.01% Shares
Legal & General Group Plc $14,482 3,162 0.01% Shares
Ameritas Investment Partners, Inc. $13,488 2,945 0.01% Shares
Russell Investments Group, Ltd. $11,880 2,594 0.01% Shares
Tower Research Capital LLC (TRC) $11,702 2,555 0.01% Shares
BlackRock, Inc. $11,601 2,533 0.01% Shares
OSAIC HOLDINGS, INC. $7,048 1,539 0.00% Shares
BARTLETT & CO. WEALTH MANAGEMENT LLC $6,105 1,333 0.00% Shares
ROYAL BANK OF CANADA $5,000 1,114 0.00% Shares
MORGAN STANLEY $3,490 762 0.00% Shares
Sterling Capital Management LLC $2,995 654 0.00% Shares
SATTER MANAGEMENT CO., L.P. $2,079 659 0.00% Shares
SBI Securities Co., Ltd. $1,452 317 0.00% Shares
Quarry LP $998 218 0.00% Shares
TD Waterhouse Canada Inc. $993 232 0.00% Shares
FMR LLC $779 170 0.00% Shares
ACADIAN ASSET MANAGEMENT LLC $778 170,883 0.00% Shares
Caitong International Asset Management Co., Ltd $664 145 0.00% Shares
Integrated Wealth Concepts LLC $604 132 0.00% Shares
PRICE T ROWE ASSOCIATES INC /MD/ $122 26,609 0.00% Shares
CWM, LLC $86 25 0.00% Shares
SIMPLEX TRADING, LLC $82 18 0.00% Shares
Virtu Financial LLC $66 14,479 0.00% Shares
Parallel Advisors, LLC $37 8 0.00% Shares

Company insiders 24 insiders · 9 officers · 16 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
David James Lennon Chief Executive Officer Oct. 2, 2023 A 0 0 $0
Scott M. Giacobello CFO, Interim CEO & President April 3, 2023 A 20,000 0 0 $0
Brendan Delaney President and Chief Executive Officer March 1, 2023 A 20,000 0 0 $0
Stephen J Hoffman Chief Executive Officer May 14, 2019 A 31,967 0 0 $0
Joseph H. Gardner President March 16, 2020 A 453,019 0 0 $0
Lorettta M Itri Chief Medical Officer March 1, 2023 A 0 0 $0
Kevin G. Peters Chief Scientific Officer and Acting Chief Medical Officer Exhibit 24: Power of Attorney March 16, 2020 A 320,536 0 0 $0
Michael W Rogers Chief Financial and Chief Business Officer May 14, 2019 A 0 0 $0
Steve Pakola Chief Medical Officer Feb. 15, 2019 A 0 0 $0
Baiteng Zhao Director June 12, 2026 A 0 0 $0
Neil Desai Director June 12, 2026 A 1,453,543 0 0 $0
Emma Reeve Director June 12, 2026 A 0 0 $0
Mohammad Hirmand Director June 12, 2026 A 0 0 $0
Anupam Dalal Director June 12, 2026 A 4,685,912 0 0 $0
Richard E Maroun Director June 12, 2026 A 0 0 $0
Caley Castelein Director June 12, 2026 A 274,796 0 0 $0
Karin M. Hehenberger Director June 15, 2023 A 0 0 $0
Cheryl Cohen Director June 17, 2021 A 8,020 0 0 $0
Chau Quang Khuong Director June 18, 2019 A 5,193,946 0 0 $0
Satter Muneer A Director June 18, 2019 A 5,621,835 0 0 $0
Paul M Weiss Director March 15, 2017 P 1,576,167 0 0 $0
Dugel Pravin June 30, 2021 A 12,568 0 0 $0
Steven Prelack June 30, 2021 A 24,485 0 0 $0
Regina Marek March 16, 2020 A 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 13 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
ACUTA CAPITAL PARTNERS, LLC, ANUPAM DALAL, Acuta Capital Fund, LP ×3 filings May 18, 2026 9.00% Amendment Passive investment SEC
Avoro Capital Advisors LLC, Avoro Ventures LLC, Behzad Aghazadeh ×6 filings May 14, 2026 19.99% Amendment SEC
Neil Desai ×5 filings March 6, 2025 4.90% Amendment SEC
BML Investment Partners, L.P., Leonard Braden Michael ×5 filings March 5, 2025 4.98% Amendment SEC
Muneer A. Satter (2) ×5 filings Nov. 12, 2021 Initial filing SEC
OrbiMed Advisors LLC, OrbiMed Capital GP V LLC ×4 filings Sept. 3, 2021 Initial filing SEC
Novartis Bioventures Ltd., Novartis AG ×7 filings May 15, 2020 Initial filing SEC
Kearny Venture Partners, L.P. (“KVP”), Kearny Venture Partners Entrepreneurs’ Fund, L.P. (“KVPE”), Kearny Venture Associates, L.L.C. (“KVA”), Caley Castelein (“Castelein”), Richard Spalding (“Spalding”), James Shapiro (“Shapiro”) ×2 filings Oct. 4, 2018 Initial filing SEC
Novartis Bioventures Ltd. (2), Novartis AG (2) March 27, 2017 Initial filing SEC
Venture Investors Early Stage Fund IV Limited Partnership (2), VIESF IV GP LLC (2) March 27, 2017 Initial filing SEC
Undisclosed reporting person April 4, 2008 Initial filing SEC
Undisclosed reporting person April 4, 2008 Initial filing SEC
Argyris Vassiliou April 4, 2008 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 10 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
QQQS · Invesco Exchange-Traded Fund Trust … 0.50% 23,692 SH Aug. 8, 2026 Daily
IWC · iShares Trust 0.03% 110,575 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.01% 28,211 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.01% 278,917 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.00% 719,241 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.00% 20,759 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 470,854 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 887,972 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.00% 187,597 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 3,409 SH Aug. 8, 2026 Daily