your badges 52W Range $4–$55 0% of range Analyst Rating HOLD 17 analysts Price Target $21 +483% upside P/E -1.9 ROE -23.4% Net Profit Margin ·

SION Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $3.60
Market Cap (MRQ) $163M
P/E -1.9
EPS $-1.88
ROE -23.4%
52W Range $4–$55

SION Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
range
bars

Bar granularity adapts to the selected period — hover the chart to see open/high/low/close for a bar.

10-Year Performance Revenue, net income, margins and EPS trends

06
EPS$-1.88
2024-12-31 → 2025-12-31
Free Cash Flow$-67M
2025-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend SION 5Y avg Peer Median Verdict
P/E -1.9 · · ·
P/B (MRQ) 0.6 · 5.5 Overvalued
Price / FCF (TTM) -2.1 · · ·
Price / Cash Flow (TTM) -2.1 · · ·
Price / Tangible Book 0.5 · · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise 0.15%
Next Report Nov 11, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 17, 2026 $-0.66 $-0.66 0.38%
March 31, 2026 May 18, 2026 $-0.60 $-0.52 -14.4%
Dec. 31, 2025 $-0.46 $-0.55 16.3%
Sept. 30, 2025 $-0.46 $-0.49 6.9%
June 30, 2025 $-0.41 $-0.57 27.6%
March 31, 2025 $-0.62 $-0.46 -35.8%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 13
Metric Trend 20252024
R&D Expense $60M$57M
SG&A Expense $29M$13M
Operating Expenses $89M$71M
Operating Income $-89M$-71M
Interest Income $13M$8M
Other Non-op $14M$9M
Income Tax $0$0
Net Income $-75M$-62M
EPS (Basic) $-1.88$-15.99
EPS (Diluted) $-1.88$-15.99
Shares (Basic) 39,962,1633,858,859
Shares (Diluted) 39,962,1633,858,859
EBITDA $-89M·
Balance Sheet 19
Metric Trend 20252024
Cash & Equivalents $58M$38M
Prepaid Expense $6M$3M
Current Assets $241M$151M
PP&E (Net) $2M$2M
PP&E (Gross) $4M$4M
Accum. Depreciation $2M$2M
Other Non-current Assets $0$3M
Total Assets $326M$186M
Accrued Liabilities $10M$8M
Current Liabilities $12M$10M
Capital Leases $7M$9M
Total Liabilities $19M$19M
Common Stock $45.0K$5.0K
Paid-in Capital $563M$17M
Retained Earnings $-256M$-181M
AOCI $540.0K$368.0K
Stockholders' Equity $307M$-164M
Liabilities + Equity $326M$186M
Shares Outstanding 44,723,5854,722,763
Cash Flow 7
Metric Trend 20252024
Stock-based Comp $12M$4M
Operating Cash Flow $-66M$-53M
CapEx $377.0K$27.0K
Investing Cash Flow $-119M$-127M
Financing Cash Flow $206M$179M
Net Change in Cash $21M$-733.0K
Free Cash Flow $-67M·
Profitability 2
Metric Trend 20252024
ROA -29.4%·
ROE -23.4%·
Liquidity & Solvency 2
Metric Trend 20252024
Current Ratio 20.6·
Quick Ratio 5.0·
Per Share 4
Metric Trend 20252024
Book Value / Share $6.86·
Cash Flow / Share $-1.66·
Cash / Share $1.31·
EPS (TTM) $-1.88$-15.99
Valuation (TTM) 8
Metric Trend 20252024
Net Income TTM $-75M$-62M
Market Cap $1.84B·
P/E -21.9·
P/B 6.0·
P / Tangible Book 6.0·
P / Cash Flow -27.8·
P / FCF -27.6·
Earnings Yield -4.6%·

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-31
Net Income $-75M $-62M
Diluted EPS $-1.88 $-15.99

Institutional owners (13F) 162 filers · $2.2B total · As of Sept. 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 162
Value held $2.2B
New positions 43
Exited positions 8
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
43 (+10 vs prior Q) 8 (-2 vs prior Q) 55 (+15 vs prior Q) 39 (+12 vs prior Q) +3.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
RA CAPITAL MANAGEMENT, L.P. $435,722,930 9,905,045 20.26% Shares
TPG GP A, LLC $285,713,378 6,494,962 13.29% Shares
VIKING GLOBAL INVESTORS LP $140,556,012 3,195,181 6.54% Shares
Atlas Venture Life Science Advisors, LLC $131,776,532 2,995,602 6.13% Shares
ORBIMED ADVISORS LLC $112,433,029 2,555,877 5.23% Shares
ENAVATE SCIENCES GP, LLC $109,008,540 2,478,030 5.07% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $70,384,000 1,600,000 3.27% Shares
BlackRock, Inc. $64,875,089 1,474,769 3.02% Shares
JPMORGAN CHASE & CO $64,085,673 1,490,508 2.98% Shares
JENNISON ASSOCIATES LLC $51,562,131 1,172,133 2.40% Shares
CITADEL ADVISORS LLC $50,484,507 1,147,636 2.35% Shares
VANGUARD CAPITAL MANAGEMENT LLC $49,796,724 1,132,001 2.32% Shares
VANGUARD GROUP INC $48,748,883 1,184,951 2.27% Shares
STATE STREET CORP $44,937,281 1,021,534 2.09% Shares
PERCEPTIVE ADVISORS LLC $39,810,950 905,000 1.85% Shares
DEERFIELD MANAGEMENT COMPANY, L.P. $29,953,495 680,916 1.39% Shares
Siren, L.L.C. $26,856,555 610,515 1.25% Shares
EVENTIDE ASSET MANAGEMENT, LLC $20,894,402 474,981 0.97% Shares
GEODE CAPITAL MANAGEMENT, LLC $20,113,984 457,145 0.94% Shares
Casdin Capital, LLC $17,596,000 400,000 0.82% Shares
BAKER BROS. ADVISORS LP $17,596,000 400,000 0.82% Shares
GOLDMAN SACHS GROUP INC $17,103,752 388,810 0.80% Shares
Driehaus Capital Management LLC $16,955,814 385,447 0.79% Shares
FRANKLIN RESOURCES INC $12,762,071 290,113 0.59% Shares
Aberdeen Group plc $12,499,231 284,138 0.58% Shares
FMR LLC $12,242,065 278,292 0.57% Shares
MILLENNIUM MANAGEMENT LLC $12,173,485 276,733 0.57% Shares
Candriam S.C.A. $10,248,950 233,208 0.48% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $9,807,527 222,949 0.46% Shares
Kalehua Capital Management LLC $8,669,197 197,072 0.40% Shares
Longaeva Partners L.P. $8,637,524 196,352 0.40% Shares
Artisan Partners Limited Partnership $8,336,017 189,498 0.39% Shares
Ensign Peak Advisors, Inc $8,117,563 184,532 0.38% Shares
Soleus Capital Management, L.P. $7,816,451 177,687 0.36% Shares
NORTHERN TRUST CORP $6,795,399 154,476 0.32% Shares
MORGAN STANLEY $6,644,558 151,047 0.31% Shares
Sofinnova Investments, Inc. $6,353,564 144,432 0.30% Shares
Qube Research & Technologies Ltd $6,172,193 140,309 0.29% Shares
Alyeska Investment Group, L.P. $5,992,406 136,222 0.28% Shares
GordonMD Global Investments LP $5,982,640 136,000 0.28% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $5,707,834 129,753 0.27% Shares
Sio Capital Management, LLC $5,622,274 127,808 0.26% Shares
Y-Intercept (Hong Kong) Ltd $5,559,215 1,056,885 0.26% Shares
VANGUARD FIDUCIARY TRUST CO $5,342,234 121,442 0.25% Shares
Artia Global Partners LP $5,267,407 119,741 0.24% Shares
UBS Group AG $5,111,902 116,206 0.24% Shares
First Turn Management, LLC $4,860,587 110,493 0.23% Shares
CITIGROUP INC $4,846,070 110,163 0.23% Shares
Ikarian Capital, LLC $4,728,925 107,500 0.22% Put option
D. E. Shaw & Co., Inc. $4,471,320 101,644 0.21% Shares

Show all 162 institutional owners →

Activists & 5%+ owners 6 positions

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Peter Kolchinsky, RA Capital Healthcare Fund, L.P., RA Capital Management, L.P., RA Capital Nexus Fund III, L.P., Rajeev Shah Sept. 21, 2026 14.30% Amendment · SEC
ORBIMED ADVISORS LLC, OrbiMed Capital GP VIII LLC ×2 filings April 20, 2026 6.60% Amendment · SEC
RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P., RA Capital Nexus Fund III, L.P. ×2 filings Nov. 7, 2025 22.60% Amendment · SEC
Atlas Venture Fund XI, L.P., Atlas Venture Associates XI, L.P., Atlas Venture Associates XI, LLC, Atlas Venture Opportunity Fund II, L.P., Atlas Venture Associates Opportunity II, LP, Atlas Venture Associates Opportunity II, LLC ×2 filings Oct. 20, 2025 5.40% Amendment · SEC
TPG GP A, LLC, James G. Coulter, Jon Winkelried Feb. 18, 2025 15.20% Initial filing Capital structure SEC
Enavate Sciences GP, LLC, Sionna Aggregator, LP Feb. 18, 2025 5.60% Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 13 insiders · 5 officers · 9 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Michael Cloonan President & CEO Sept. 17, 2026 D 765,393 0 0 $0
Elena Ridloff CFO and CBO Sept. 17, 2026 D 133,069 0 0 $0
Jennifer Fitzpatrick CLO and Head of Program Mgmt. Sept. 17, 2026 D 56,265 0 3 $-1,209,295
Charlotte Mckee CMO and Head of R&D Sept. 17, 2026 D 128,415 0 0 $0
Caroline Stark Beer Chief Business Officer Jan. 2, 2026 A · 0 0 $0
Peter A. Thompson Director July 7, 2026 S 2,469,959 0 20 $-55,674,636
Marcella K. Ruddy Director June 17, 2026 A · 0 0 $0
Harold Edward Fleming Director June 17, 2026 A · 0 0 $0
Joanne L. Viney Director June 17, 2026 A · 0 0 $0
Joshua Resnick Director June 17, 2026 A · 0 0 $0
Laurie Stelzer Director June 17, 2026 A · 0 0 $0
Bruce Booth Director June 17, 2026 A 686,567 0 0 $0
Paul J Clancy Director June 17, 2026 A · 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 23 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBC · ETFis Series Trust I 0.88% 8,653 NS July 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.21% 22,009 NS July 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.12% 55,058 SH Aug. 19, 2026 Daily
PWS · Pacer Funds Trust 0.06% 301 NS July 31, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.05% 19,765 SH Aug. 19, 2026 Daily
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.04% 5,243 NS July 31, 2026 N-PORT
RSSL · Global X Funds 0.03% 8,820 NS July 31, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.02% 106,139 SH Aug. 19, 2026 Daily
IBB · iShares Trust 0.01% 200,019 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.01% 3,375 SH Oct. 23, 2026 Daily
JDOC · J.P. Morgan Exchange-Traded Fund Tr… 0.01% 21 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.01% 168,317 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 40,627 SH Aug. 19, 2026 Daily
IWO · iShares Trust 0.01% 173,168 SH Sept. 11, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.01% 6,417 NS July 31, 2026 N-PORT
IWM · iShares Trust 0.00% 475,073 SH Sept. 11, 2026 Daily
ESSC · Strategy Shares 0.00% 12 NS July 31, 2026 N-PORT
WSML · iShares Trust 0.00% 836 SH Sept. 11, 2026 Daily
ITOT · iShares Trust 0.00% 21,708 SH Sept. 11, 2026 Daily
IWV · iShares Trust 0.00% 4,371 SH Sept. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 934,641 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 1,360 SH Aug. 19, 2026 Daily
ISCB · iShares Trust · 854 SH Sept. 11, 2026 Daily

SION Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 17 analysts HOLD
Median target $6.00 +66.7%
2 11.8% Strong Buy
4 23.5% Buy
11 64.7% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

7 analysts · 2026-10-21

Mean target $21.00 +483.3%

← Below all targets Current price $3.60
Low$5.00 Mean$21.00 High$63.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SION $1.84B -21.9 · · -23.4% ·
IVVD $697M -8.2 110.5% -98.2% -36.9% ·
KRRO $75M -0.6 181.5% -1834.5% -140.8% ·
PEPG $448M -3.1 · · -82.0% ·
TRDA $394M -3.0 -87.9% -565.5% -41.9% ·
ALXO $61M -0.6 · · -225.0% ·
AKBA $427M -80.5 47.5% -2.3% -17.3% ·
CHRS $172M 1.0 59.8% 398.4% 185.8% ·
STRO $99M -0.5 65.2% -186.5% 232.2% ·
NBP $1.06B -19.0 · · -21.4% ·
UPB $1.47B -10.2 20.4% -5026.0% -38.3% ·

Latest News Recent headlines mentioning this company

23
Wedbush Initiates Coverage of Sionna Therapeutics (SION) Yahoo Finance · Sionna Insider Sells $2.5 Million in Stock Amid 215% Surge, but Here's What Investors Should Watch Nasdaq ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

Pick the metrics that matter to you — click the + next to any row in Full Fundamentals above.

Your selection is saved and follows you across all tickers.

Source: SEC 10-Q filed Aug 6, 2026