ZYME — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| EcoR1 Capital, LLC | $600,445,942 | 22,970,388 | 32.29% | Shares |
| Rubric Capital Management LP | $182,980,000 | 7,000,000 | 9.84% | Shares |
| BlackRock, Inc. | $111,121,925 | 4,251,030 | 5.98% | Shares |
| PERCEPTIVE ADVISORS LLC | $109,342,391 | 4,182,953 | 5.88% | Shares |
| BVF INC/IL | $95,388,572 | 3,649,142 | 5.13% | Shares |
| VANGUARD GROUP INC | $61,315,382 | 2,328,727 | 3.30% | Shares |
| MORGAN STANLEY | $58,325,141 | 2,231,260 | 3.14% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $46,558,373 | 1,781,116 | 2.50% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $40,752,208 | 1,558,998 | 2.19% | Shares |
| Assenagon Asset Management S.A. | $32,727,986 | 1,252,027 | 1.76% | Shares |
| Nextech Invest Ltd. | $29,118,548 | 1,113,946 | 1.57% | Shares |
| STATE STREET CORP | $28,445,966 | 1,088,216 | 1.53% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $25,995,770 | 994,955 | 1.40% | Shares |
| CITADEL ADVISORS LLC | $23,895,516 | 914,136 | 1.29% | Shares |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $23,259,000 | 889,802 | 1.25% | Shares |
| FMR LLC | $18,365,133 | 702,568 | 0.99% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $18,099,012 | 692,410 | 0.97% | Shares |
| Prosight Management, LP | $17,629,705 | 674,434 | 0.95% | Shares |
| Qube Research & Technologies Ltd | $15,516,443 | 593,590 | 0.83% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $13,332,236 | 510,032 | 0.72% | Shares |
| Redmile Group, LLC | $12,851,836 | 491,654 | 0.69% | Shares |
| Capricorn Fund Managers Ltd | $12,717,868 | 486,529 | 0.68% | Shares |
| GOLDMAN SACHS GROUP INC | $12,307,288 | 470,822 | 0.66% | Shares |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $10,939,512 | 418,497 | 0.59% | Shares |
| DEUTSCHE BANK AG\ | $10,382,547 | 397,190 | 0.56% | Shares |
| Hillsdale Investment Management Inc. | $10,009,581 | 382,922 | 0.54% | Shares |
| FIRST TRUST ADVISORS LP | $8,897,088 | 340,363 | 0.48% | Shares |
| Granahan Investment Management, LLC | $8,787,144 | 336,157 | 0.47% | Shares |
| NORTHERN TRUST CORP | $8,392,849 | 321,073 | 0.45% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $7,997,401 | 319,385 | 0.43% | Shares |
| Pictet Asset Management Holding SA | $7,446,189 | 308,187 | 0.40% | Shares |
| PICTON MAHONEY ASSET MANAGEMENT | $7,092,908 | 271,343 | 0.38% | Shares |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $5,849,243 | 223,766 | 0.31% | Shares |
| BANK OF AMERICA CORP /DE/ | $5,726,515 | 219,071 | 0.31% | Shares |
| WELLS FARGO & COMPANY/MN | $5,677,573 | 217,199 | 0.31% | Shares |
| SummitTX Capital, L.P. | $5,510,364 | 210,802 | 0.30% | Shares |
| Man Group plc | $5,509,763 | 210,779 | 0.30% | Shares |
| FEDERATED HERMES, INC. | $4,914,190 | 187,995 | 0.26% | Shares |
| RAYMOND JAMES FINANCIAL INC | $4,350,114 | 166,416 | 0.23% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $4,066,835 | 155,579 | 0.22% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3,984,154 | 152,416 | 0.21% | Shares |
| KENNEDY CAPITAL MANAGEMENT LLC | $3,800,390 | 145,386 | 0.20% | Shares |
| D. E. Shaw & Co., Inc. | $3,785,255 | 144,807 | 0.20% | Shares |
| DIADEMA PARTNERS LP | $3,715,330 | 142,132 | 0.20% | Shares |
| CITIGROUP INC | $3,435,868 | 131,441 | 0.18% | Shares |
| Bank of New York Mellon Corp | $3,427,107 | 131,106 | 0.18% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3,408,656 | 130,400 | 0.18% | Call option |
| XTX Topco Ltd | $3,290,425 | 125,877 | 0.18% | Shares |
| Nuveen, LLC | $3,120,829 | 119,389 | 0.17% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $3,100,282 | 118,603 | 0.17% | Shares |
| UBS Group AG | $3,008,583 | 115,095 | 0.16% | Shares |
| Invesco Ltd. | $2,933,222 | 112,212 | 0.16% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $2,908,911 | 111,282 | 0.16% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $2,875,766 | 110,014 | 0.15% | Shares |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2,749,510 | 105,184 | 0.15% | Shares |
| AXA Investment Managers S.A. | $2,705,745 | 158,416 | 0.15% | Shares |
| Manatuck Hill Partners, LLC | $2,614,000 | 100,000 | 0.14% | Shares |
| JPMORGAN CHASE & CO | $2,564,192 | 106,398 | 0.14% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2,451,932 | 93,800 | 0.13% | Put option |
| KORNITZER CAPITAL MANAGEMENT INC /KS | $2,321,232 | 88,800 | 0.12% | Shares |
| MACKENZIE FINANCIAL CORP | $2,293,654 | 87,745 | 0.12% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $2,221,639 | 84,990 | 0.12% | Shares |
| Y-Intercept (Hong Kong) Ltd | $2,181,514 | 83,455 | 0.12% | Shares |
| LMR Partners LLP | $2,156,550 | 82,500 | 0.12% | Shares |
| AMERIPRISE FINANCIAL INC | $2,150,380 | 82,264 | 0.12% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $2,094,337 | 80,120 | 0.11% | Shares |
| STIFEL FINANCIAL CORP | $2,018,373 | 77,214 | 0.11% | Shares |
| FRANKLIN RESOURCES INC | $2,000,443 | 76,528 | 0.11% | Shares |
| TEMA ETFS LLC | $2,000,422 | 75,975 | 0.11% | Shares |
| RHUMBLINE ADVISERS | $1,962,211 | 75,066 | 0.11% | Shares |
| Swiss National Bank | $1,939,588 | 74,200 | 0.10% | Shares |
| MARTINGALE ASSET MANAGEMENT L P | $1,915,592 | 73,282 | 0.10% | Shares |
| TWO SIGMA INVESTMENTS, LP | $1,878,786 | 71,874 | 0.10% | Shares |
| Dana Investment Advisors, Inc. | $1,873,192 | 71,660 | 0.10% | Shares |
| CREDIT AGRICOLE S A | $1,855,940 | 71,000 | 0.10% | Shares |
| Fisher Asset Management, LLC | $1,850,057 | 70,775 | 0.10% | Shares |
| SEGALL BRYANT & HAMILL, LLC | $1,747,093 | 66,836 | 0.09% | Shares |
| Verdad Advisers, LP | $1,743,224 | 66,688 | 0.09% | Shares |
| Susquehanna Portfolio Strategies, LLC | $1,705,583 | 65,248 | 0.09% | Shares |
| Campbell & CO Investment Adviser LLC | $1,591,246 | 60,874 | 0.09% | Shares |
| ROYAL BANK OF CANADA | $1,471,000 | 56,278 | 0.08% | Shares |
| ALLIANCEBERNSTEIN L.P. | $1,399,636 | 55,896 | 0.08% | Shares |
| CITADEL ADVISORS LLC | $1,364,508 | 52,200 | 0.07% | Call option |
| Virtus Investment Advisers, LLC | $1,328,566 | 50,825 | 0.07% | Shares |
| ENVESTNET ASSET MANAGEMENT INC | $1,272,365 | 48,675 | 0.07% | Shares |
| Russell Investments Group, Ltd. | $1,251,241 | 47,867 | 0.07% | Shares |
| Quantinno Capital Management LP | $1,245,362 | 47,642 | 0.07% | Shares |
| Legal & General Group Plc | $1,128,017 | 43,160 | 0.06% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $1,111,577 | 42,524 | 0.06% | Shares |
| MARSHALL WACE, LLP | $1,070,380 | 40,948 | 0.06% | Shares |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $1,033,419 | 39,534 | 0.06% | Shares |
| Aquilo Capital Management, LLC | $1,006,181 | 84,482 | 0.05% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $986,628 | 37,744 | 0.05% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $965,141 | 36,922 | 0.05% | Shares |
| TUDOR INVESTMENT CORP ET AL | $953,352 | 36,471 | 0.05% | Shares |
| HighTower Advisors, LLC | $943,654 | 36,100 | 0.05% | Shares |
| Persistent Asset Partners Ltd | $939,341 | 35,935 | 0.05% | Shares |
| HighVista Strategies LLC | $889,100 | 34,013 | 0.05% | Shares |
| COMMONWEALTH EQUITY SERVICES, LLC | $837,838 | 32,052 | 0.05% | Shares |
| TWO SIGMA ADVISERS, LP | $827,157 | 31,415 | 0.04% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $807,360 | 30,886 | 0.04% | Shares |
| Creative Planning | $777,168 | 29,731 | 0.04% | Shares |
| SBI Okasan Asset Management Co.Ltd. | $771,200 | 32,000 | 0.04% | Shares |
| MetLife Investment Management, LLC | $728,888 | 27,884 | 0.04% | Shares |
| JOURNEY STRATEGIC WEALTH LLC | $727,412 | 29,050 | 0.04% | Shares |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $723,294 | 27,670 | 0.04% | Shares |
| STRS OHIO | $692,710 | 26,500 | 0.04% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $686,933 | 26,279 | 0.04% | Shares |
| Brevan Howard Capital Management LP | $678,490 | 25,956 | 0.04% | Shares |
| Jump Financial, LLC | $669,393 | 25,608 | 0.04% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $657,735 | 25,162 | 0.04% | Shares |
| RITHOLTZ WEALTH MANAGEMENT | $633,712 | 24,243 | 0.03% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $607,206 | 23,229 | 0.03% | Shares |
| Duncan Williams Asset Management, LLC | $577,563 | 22,095 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $564,049 | 21,578 | 0.03% | Shares |
| BARCLAYS PLC | $538,562 | 20,603 | 0.03% | Shares |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $508,031 | 19,435 | 0.03% | Shares |
| SIMPLEX TRADING, LLC | $507,926 | 19,431 | 0.03% | Shares |
| BetterWealth, LLC | $486,779 | 18,622 | 0.03% | Shares |
| BANK OF MONTREAL /CAN/ | $481,394 | 18,416 | 0.03% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $477,499 | 18,267 | 0.03% | Shares |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $475,356 | 18,185 | 0.03% | Shares |
| JANUS HENDERSON GROUP PLC | $455,819 | 18,200 | 0.02% | Shares |
| JANE STREET GROUP, LLC | $455,803 | 17,437 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $454,078 | 17,371 | 0.02% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $452,483 | 17,310 | 0.02% | Shares |
| Squarepoint Ops LLC | $423,468 | 16,200 | 0.02% | Shares |
| HSBC HOLDINGS PLC | $421,205 | 15,588 | 0.02% | Shares |
| Vinva Investment Management Ltd | $419,717 | 11,983 | 0.02% | Shares |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $400,988 | 15,340 | 0.02% | Shares |
| AGF MANAGEMENT LTD | $392,100 | 15,000 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $358,170 | 13,702 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $311,981 | 11,935 | 0.02% | Shares |
| State of New Jersey Common Pension Fund D | $311,667 | 11,923 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $303,799 | 11,622 | 0.02% | Shares |
| JAMES INVESTMENT RESEARCH, INC. | $285,580 | 10,925 | 0.02% | Shares |
| Ewing Morris & Co. Investment Partners Ltd. | $283,619 | 10,850 | 0.02% | Shares |
| ARIZONA STATE RETIREMENT SYSTEM | $265,975 | 10,175 | 0.01% | Shares |
| Jain Global LLC | $261,661 | 10,010 | 0.01% | Shares |
| PSP Research LLC | $261,400 | 10,000 | 0.01% | Shares |
| Mitsubishi UFJ Trust & Banking Corp | $250,134 | 9,569 | 0.01% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $243,991 | 9,334 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $230,110 | 8,803 | 0.01% | Shares |
| Allspring Global Investments Holdings, LLC | $225,359 | 8,762 | 0.01% | Shares |
| ProShare Advisors LLC | $223,681 | 8,557 | 0.01% | Shares |
| AlphaQuest LLC | $218,881 | 8,313 | 0.01% | Shares |
| INCEPTIONR LLC | $217,302 | 8,313 | 0.01% | Shares |
| Magnetar Financial LLC | $216,753 | 8,292 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $209,120 | 8,000 | 0.01% | Shares |
| PRUDENTIAL FINANCIAL INC | $207,552 | 7,940 | 0.01% | Shares |
| CWM, LLC | $174,153 | 6,955 | 0.01% | Shares |
| Vanguard Global Advisers, LLC | $142,698 | 5,459 | 0.01% | Shares |
| Northwest & Ethical Investments L.P. | $111,583 | 4,630 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $108,847 | 4,164 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $85,373 | 3,266 | 0.00% | Shares |
| Arax Advisory Partners | $78,368 | 2,998 | 0.00% | Shares |
| State of Wyoming | $72,983 | 2,792 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $62,030 | 2,373 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $41,432 | 1,585 | 0.00% | Shares |
| TD Waterhouse Canada Inc. | $37,014 | 1,439 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $34,217 | 1,309 | 0.00% | Shares |
| Eurizon Capital SGR S.p.A. | $31,865 | 1,321 | 0.00% | Shares |
| GAMMA Investing LLC | $29,120 | 1,114 | 0.00% | Shares |
| Optiver Holding B.V. | $27,159 | 1,039 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $25,382 | 971 | 0.00% | Shares |
| LANARK FINANCIAL, INC. | $25,146 | 962 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $23,474 | 898 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $23,055 | 882 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $20,214 | 837 | 0.00% | Shares |
| Freestone Grove Partners LP | $16,939 | 648 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $15,182 | 581 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $14,894 | 570 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $12,573 | 481 | 0.00% | Shares |
| UMB Bank, n.a. | $12,129 | 464 | 0.00% | Shares |
| HUNTINGTON NATIONAL BANK | $12,024 | 460 | 0.00% | Shares |
| Parallel Advisors, LLC | $8,600 | 329 | 0.00% | Shares |
| US BANCORP \DE\ | $8,234 | 315 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $8,156 | 312 | 0.00% | Shares |
| COMERICA BANK | $5,556 | 211 | 0.00% | Shares |
| Quarry LP | $5,489 | 210 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $4,888 | 187 | 0.00% | Shares |
| Lindbrook Capital, LLC | $4,419 | 371 | 0.00% | Shares |
| Sterling Capital Management LLC | $4,313 | 165 | 0.00% | Shares |
| Fortitude Family Office, LLC | $3,032 | 116 | 0.00% | Shares |
| Allworth Financial LP | $2,824 | 108 | 0.00% | Shares |
| IFP Advisors, Inc | $2,509 | 96 | 0.00% | Shares |
| Versant Capital Management, Inc | $2,490 | 94 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $2,091 | 80 | 0.00% | Shares |
| HighMark Wealth Management LLC | $2,091 | 80 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $2,013 | 77 | 0.00% | Shares |
| Kilter Group LLC | $1,726 | 66 | 0.00% | Shares |
| Bare Financial Services, Inc | $1,673 | 64 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $1,595 | 61 | 0.00% | Shares |
| True Wealth Design, LLC | $1,517 | 58 | 0.00% | Shares |
| Physician Wealth Advisors, Inc. | $1,334 | 51 | 0.00% | Shares |
| North Growth Management Ltd. | $1,201 | 46,000 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1,007 | 38,486 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $784 | 30 | 0.00% | Shares |
| Sunbelt Securities, Inc. | $676 | 27 | 0.00% | Shares |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | $643 | 25 | 0.00% | Shares |
| Jackson Creek Investment Advisors LLC | $409 | 18,648 | 0.00% | Shares |
| Essential Partners LLC | $314 | 12 | 0.00% | Shares |
| Janney Montgomery Scott LLC | $310 | 11,865 | 0.00% | Shares |
| Smartleaf Asset Management LLC | $289 | 12 | 0.00% | Shares |
| SG Americas Securities, LLC | $165 | 6,321 | 0.00% | Shares |
| Clearstead Advisors, LLC | $157 | 6 | 0.00% | Shares |
| Larson Financial Group LLC | $157 | 6 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $105 | 4 | 0.00% | Shares |
| DekaBank Deutsche Girozentrale | $94 | 3,843 | 0.00% | Shares |
| Hughes Financial Services, LLC | $78 | 3 | 0.00% | Shares |
| SHELL ASSET MANAGEMENT CO | $72 | 4,212 | 0.00% | Shares |
| Covestor Ltd | $1 | 40 | 0.00% | Shares |