ACAD ACADIA Pharmaceuticals Inc. - Common Stock

NASDAQ · Biotechnology · Voir sur SEC EDGAR ↗
$30,66
Prix · Aoû 19, 2026
Données fondamentales au Aoû 5, 2026

À propos de ACADIA Pharmaceuticals Inc. - Common Stock Présentation de l'entreprise depuis Wikipedia

Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Del Mar, California.

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Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Del Mar, California.

Product development

Nuplazid, a drug developed by Acadia in the late 1990s, "was designed to stimulate a subset of the brain’s serotonin receptors, or the proteins that govern memory, cognition and learning." On April 29, 2016, the FDA approved Acadia's drug, Nuplazid, for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. Nuplazid is the trade name for Acadia's proprietary molecule, pimavanserin, a selective serotonin inverse agonist preferentially targeting 5-HT2a receptors. Acadia had partnered with Biovail in the late-stage clinical testing of the drug, which showed trial failures as of 2009.

Acadia is running multiple Phase 2 and Phase 3 trials with pimavanserin in several central nervous system conditions: dementia-related psychosis, major depressive disorder, schizophrenia inadequate response, and schizophrenia negative symptoms.

As of 1997, Acadia was among several companies that licensed compounds from Genzyme's small-molecule compound library.

In 2023, the FDA approved trofinetide (marketed as Daybue) for use in Rett syndrome.

History

Acadia started in 1993 as Receptor Technologies, based in Winooski, Vermont. In 1997, the company relocated all operations and management from Vermont to San Diego, California, as a strategic move to garner partnerships with other biotechnology companies. However, the company also had an office in Denmark, in which it received a crucial part of its early investments from BankInvest, under managing director Florian Schönharting, Kommunernes Pensionsforsikring A/S and Dansk Kapitalanlæg Aktieselskab as well as private investor Lars Christiansen. At the time, the company had fifty employees, fourteen of whom were in the Denmark office. The focus of the company in its early years was on genetic screens for receptors, aiming to accelerate early stage drug discovery.

The company planned to conduct an initial public offering (IPO) consisting of 31.6% of the company in 2001, with the intention of raising US$64 million and listing on the NASDAQ exchange under the symbol ACAD. At the time, Acadia and Allergan were collaborating on development of a treatment for glaucoma, and Allergan would retain a 6.3% ownership stake in Acadia after the IPO. However, the company's IPO, which ultimately took place in May 2004, did not fare as well as expected and netted only US$35 million. At the time, the company had five drugs in development and was running two in human trials. The company had a subsequent round of stock offering in May 2007 which raised US$102 million.

In September 2020, Acadia Pharmaceuticals acquired clinical-stage biotechnology company CerSci Therapeutics.

Corporate governance

In 2001, the company's chief executive officer at the time, Leonard R. Borrmann, left Acadia to lead Maret Pharmaceuticals. He was succeeded by Uli Hacksell, who left Acadia to lead Cerecor at the beginning of 2016.

== References ==

Source : Wikipedia (Anglais), CC BY-SA 4.0 · Voir sur Wikipedia ↗

Wikidata ↗

ACAD Aperçu de l'action Prix, capitalisation boursière, P/E, EPS, ROE, dette/capitaux propres, fourchette sur 52 semaines

Prix
$30.66
Capitalisation Boursière
$5.22B
P/E (TTM)
13.3
BPA (TTM)
$2.30
Revenus (TTM)
$1.07B
Rendement div.
ROE
38.1%
Dette/Capitaux propres
Fourchette 52 semaines
$20 – $31

ACAD Graphique du cours de l'action OHLCV quotidien avec indicateurs techniques — panoramique, zoom et personnalisez votre vue

Performance sur 10 ans Tendances du chiffre d'affaires, du bénéfice net, des marges et du BPA

Revenus et bénéfice net $1.07B
10-point trend, +6082.6%
2016-12-31 2025-12-31
BPA $2.30
6-point trend, +228.5%
2020-12-31 2025-12-31
Flux de trésorerie libre $105M
10-point trend, +149.6%
2016-12-31 2025-12-31
Marges 36.5%
8-point trend, +14.6%
2016-12-31 2023-12-31

Valorisation Ratios P/E, P/S, P/B, EV/EBITDA — l'action est-elle chère ou bon marché ?

Métrique
Tendance sur 5 ans
ACAD
Médiane des pairs
P/E (TTM)
5-point trend, +152.2%
13.3
13.2
P/S (TTM)
5-point trend, -45.3%
4.9
55.3
P/B
5-point trend, -46.7%
4.3
3.5
Price / FCF (Cours / FCF)
5-point trend, +246.0%
49.7

Rentabilité Marges brutes, d'exploitation et nettes ; ROE, ROA, ROIC

Métrique
Tendance sur 5 ans
ACAD
Médiane des pairs
Operating Margin (Marge d'exploitation)
5-point trend, +127.8%
9.8%
Net Profit Margin (Marge nette)
5-point trend, +205.2%
36.5%
-151.2%
ROA
5-point trend, +225.5%
28.4%
-42.2%
ROE
5-point trend, +225.9%
38.1%
-52.8%
ROIC
5-point trend, +176.1%
24.0%

Santé financière Dette, liquidité, solvabilité — solidité du bilan

Métrique
Tendance sur 5 ans
ACAD
Médiane des pairs
Current Ratio (Ratio de liquidité)
5-point trend, -40.4%
3.8
10.3
Quick Ratio (Ratio de liquidité réduite)
5-point trend, -51.0%
1.1

Croissance Croissance du chiffre d'affaires, du BPA et du bénéfice net : Année/Année, TCAC 3 ans, TCAC 5 ans

Métrique
Tendance sur 5 ans
ACAD
Médiane des pairs
Revenue YoY (Chiffre d'affaires YoY)
5-point trend, +121.3%
11.9%
Revenue CAGR 3Y (CAGR du chiffre d'affaires 3 ans)
5-point trend, +121.3%
27.5%
Revenue CAGR 5Y (CAGR du chiffre d'affaires 5 ans)
5-point trend, +121.3%
19.4%
EPS YoY (BPA Année/Année)
5-point trend, +319.0%
69.1%
Net Income YoY (Bénéfice net YoY)
5-point trend, +332.9%
72.7%

Indicateurs par action BPA, valeur comptable par action, flux de trésorerie par action, dividende par action

Métrique
Tendance sur 5 ans
ACAD
Médiane des pairs
EPS (Diluted) (BPA (Dilué))
5-point trend, +319.0%
$2.30

Efficacité du capital Rotation des actifs, rotation des stocks, rotation des créances

Métrique
Tendance sur 5 ans
ACAD
Médiane des pairs

ACAD Consensus des analystes Opinions des analystes haussières et baissières, objectif de cours à 12 mois, potentiel de hausse

ACHAT 27 analystes
  • Achat fort 7 25,9%
  • Achat 14 51,9%
  • Conserver 5 18,5%
  • Vente 1 3,7%
  • Vente forte 0 0,0%

Objectif de cours à 12 mois

20 analystes · 2026-08-18
Objectif médian $36.00 +17,4%
Objectif moyen $33.85 +10,4%

Historique des bénéfices BPA réel vs estimation, surprise %, taux de succès, prochaine date de publication des résultats

Surprise Moyenne
0.30%
Période EPS Actual BPA est. Surprise
30 juin 2026 $0.18 $0.06 0.12%
31 mars 2026 $0.02 $0.06 -0.04%
31 décembre 2025 $1.60 $0.14 1.5%
30 septembre 2025 $0.42 $0.15 0.27%
30 juin 2025 $0.16 $0.14 0.02%
31 mars 2025 $0.11 $0.11 -0.00%

Comparaison des pairs (sous-secteur GICS) Indicateurs clés par rapport aux pairs du secteur

Ticker Capitalisation Boursière P/E Revenus Année/Année Marge Nette ROE Marge Brute
ACAD $4.55B 11.6 11.9% 36.5% 38.1%
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8%
ERAS $1.06B -8.5 -35.7%
CAI $7.62B -8.4 97.0% -8.4% -13.2%
PTCT $6.19B 9.8 114.5% 39.4% -331.5%
TVTX $3.47B -131.8 110.5% -5.2% -34.6%
DYN $3.23B -5.6 -57.8%
PBLS
CELC $4.81B -26.3 -244.3%
RLAY $1.47B -5.3 53.4% -1800.6% -44.9%

Fondamentaux complets Tous les indicateurs par an — compte de résultat, bilan, flux de trésorerie

Compte de résultat 16
Données annuelles Compte de résultat pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +892820.8% $1.07B $958M $726M $517M $484M $442M $339M $224M $125M $17M $61.0K $120.0K
Cost of Revenue 10-point trend, +2794.2% $89M $82M $42M $10M $19M $10M $11M $12M $9M $3M · ·
Gross Profit 8-point trend, +4704.9% · · $685M $507M $473M $432M $328M $211M $116M $14M · ·
R&D Expense 12-point trend, +442.6% $329M $303M $352M $362M $239M $319M $240M $187M $149M $99M $74M $61M
SG&A Expense 12-point trend, +1576.1% $549M $488M $407M $369M $396M $389M $326M $266M $255M $186M $88M $33M
Operating Expenses 12-point trend, +935.6% $967M $727M $800M $741M $655M $728M $586M $471M $417M $290M $165M $93M
Operating Income 12-point trend, +212.4% $105M $231M $-73M $-224M $-170M $-287M $-247M $-247M $-292M $-273M $-165M $-93M
Other Non-op 8-point trend, +228.9% $2M $2M $5M $4M $2M $-997.0K $997.0K $-2M · · · ·
Pretax Income 12-point trend, +250.2% $139M $258M $-51M $-213M $-168M $-281M $-234M $-244M $-288M $-270M $-164M $-92M
Income Tax 12-point trend, -252096000.00 $-252M $32M $10M $3M $351.0K $611.0K $876.0K $1M $1M $1M $330.0K $0
Net Income 12-point trend, +522.8% $391M $226M $-61M $-216M $-168M $-282M $-235M $-245M $-289M $-271M $-164M $-92M
EPS (Basic) 6-point trend, +229.6% $2.32 $1.37 $-0.37 $-1.34 $-1.05 $-1.79 · · · · · ·
EPS (Diluted) 6-point trend, +228.5% $2.30 $1.36 $-0.37 $-1.34 $-1.05 $-1.79 · · · · · ·
Shares (Basic) 6-point trend, +106907.5% 168,356,000 165,717,000 163,819,000 161,683,000 160,493 157,331 · · · · · ·
Shares (Diluted) 6-point trend, +107901.0% 169,919,000 166,362,000 163,819,000 161,683,000 160,493 157,331 · · · · · ·
EBITDA 12-point trend, +212.4% $105M $231M $-73M $-224M $-170M $-287M $-247M $-247M $-292M $-273M $-165M $-93M
Bilan 25
Données annuelles Bilan pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +187.3% $178M $320M $189M $115M $147M $326M $190M $135M $69M $164M $102M $62M
Receivables 10-point trend, +1957.5% $121M $99M $98M $62M $64M $48M $36M $26M $17M $6M · ·
Inventory 10-point trend, +2567.6% $111M $92M $40M $12M $14M $10M $6M $4M $5M $4M · ·
Prepaid Expense 12-point trend, +4996.4% $60M $56M $39M $21M $24M $26M $19M $21M $8M $8M $2M $1M
Current Assets 12-point trend, +227.2% $1.06B $938M $616M $508M $618M $718M $760M $526M $373M $548M $219M $325M
PP&E (Net) 12-point trend, +1258.2% $8M $4M $5M $6M $8M $9M $3M $3M $3M $3M $2M $553.0K
PP&E (Gross) 12-point trend, +531.1% $17M $14M $14M $14M $14M $13M $9M $8M $7M $6M $5M $3M
Accum. Depreciation 12-point trend, +343.2% $9M $10M $10M $8M $6M $4M $5M $4M $4M $3M $3M $2M
Intangibles 10-point trend, +1452.3% $109M $120M $65M $0 $0 $1M $3M $4M $6M $7M · ·
Other Non-current Assets 12-point trend, +1257.5% $4M $359.0K $476.0K $8M $4M $2M $3M $2M $354.0K $785.0K $329.0K $287.0K
Total Assets 12-point trend, +380.6% $1.56B $1.19B $749M $588M $700M $783M $783M $540M $385M $561M $222M $325M
Accounts Payable 12-point trend, +440.8% $11M $16M $18M $13M $7M $8M $7M $3M $9M $4M $2M $2M
Accrued Liabilities 12-point trend, +1826.6% $266M $379M $237M $113M $89M $97M $68M $56M $40M $36M $20M $14M
Current Liabilities 12-point trend, +1650.1% $277M $395M $254M $126M $96M $106M $75M $60M $49M $43M $22M $16M
Capital Leases 7-point trend, +537.5% $41M $42M $48M $53M $56M $44M $6M · · · · ·
Deferred Tax 7-point trend, +345.4% $11M $11M $12M $13M $14M $13M $3M · · · · ·
Other Non-current Liabilities 8-point trend, +1128.3% $19M $18M $15M $9M $7M $5M $3M $2M · · · ·
Total Liabilities 12-point trend, +2009.1% $337M $455M $317M $187M $159M $156M $84M $61M $49M $43M $22M $16M
Common Stock 12-point trend, +60.0% $16.0K $16.0K $16.0K $16.0K $16.0K $16.0K $15.0K $14.0K $12.0K $12.0K $10.0K $10.0K
Paid-in Capital 3-point trend, +79.8% · · · · · · · · · $1.45B $862M $808M
Retained Earnings 12-point trend, -264.0% $-1.81B $-2.20B $-2.43B $-2.37B $-2.15B $-1.99B $-1.70B $-1.47B $-1.22B $-934M $-663M $-498M
AOCI 12-point trend, +16155.6% $1M $292.0K $24.0K $-975.0K $-192.0K $36.0K $297.0K $-372.0K $-399.0K $106.0K $11.0K $-9.0K
Stockholders' Equity 12-point trend, +296.6% $1.23B $733M $432M $400M $541M $627M $699M $479M $335M $518M $200M $309M
Liabilities + Equity 12-point trend, +380.6% $1.56B $1.19B $749M $588M $700M $783M $783M $540M $385M $561M $222M $325M
Shares Outstanding 12-point trend, +70.2% 170,309,376 166,708,856 164,650,219 162,064,872 161,012,695 159,637,771 155,275,300 143,853,597 124,410,552 121,367,169 101,938,702 100,047,331
Flux de trésorerie 13
Données annuelles Flux de trésorerie pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
D&A · · · · · · · · · · · $206.0K
Stock-based Comp 12-point trend, +225.1% $52M $67M $66M $68M $64M $84M $82M $82M $76M $55M $40M $16M
Deferred Tax 5-point trend, -71417.4% $-250M $0 $0 $3M $351.0K · · · · · · ·
Amort. of Intangibles 12-point trend, +10889000.00 $11M $15M $4M $0 $1M $1M $1M $1M $1M $985.0K $0 $0
Operating Cash Flow 12-point trend, +265.3% $110M $158M $17M $-114M $-126M $-136M $-151M $-167M $-218M $-208M $-122M $-66M
CapEx 12-point trend, +2505.6% $5M $523.0K $50.0K $0 $1M $8M $1M $2M $812.0K $2M $2M $180.0K
Investing Cash Flow 10-point trend, -15.5% $-303M $-31M $32M $73M $-71M $193M $-166M $-71M $92M $-262M · ·
Stock Issued 12-point trend, -75.5% $50M $7M $25M $8M $18M $81M $372M $307M $31M $519M $15M $204M
Net Stock Activity 12-point trend, -75.5% $50M $7M $25M $8M $18M $81M $372M $307M $31M $519M $15M $204M
Financing Cash Flow 10-point trend, -90.7% $50M $7M $25M $8M $18M $81M $372M $307M $31M $534M · ·
Net Change in Cash 12-point trend, -384.8% $-143M $134M $74M $-33M $-179M $137M $55M $68M $-94M $63M $40M $50M
Taxes Paid 11-point trend, +5965.1% $25M $20M $6M $2M $1M $1M $2M $1M $1M $-365.0K $415.0K ·
Free Cash Flow 12-point trend, +257.8% $105M $157M $17M $-114M $-127M $-144M $-152M $-170M $-219M $-212M $-124M $-67M
Rentabilité 8
Données annuelles Rentabilité pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Gross Margin 8-point trend, +14.6% · · 94.3% 98.0% 97.8% 97.7% 96.7% 94.5% 92.7% 82.2% · ·
Operating Margin 12-point trend, +100.0% 9.8% 24.1% -10.1% -43.2% -35.2% -64.9% -72.7% -110.6% -234.1% -1574.1% -269855.7% -77691.7%
Net Margin 12-point trend, +100.0% 36.5% 23.6% -8.4% -41.8% -34.7% -63.7% -69.4% -109.6% -231.7% -1565.9% -269578.7% -77062.5%
Pretax Margin 11-point trend, +100.0% 13.0% 26.9% -7.0% -41.3% -34.6% -63.6% -69.1% -109.0% -230.8% -1558.2% -269037.7% ·
EBITDA Margin 12-point trend, +100.0% 9.8% 24.1% -10.1% -43.2% -35.2% -64.9% -72.7% -110.6% -234.1% -1574.1% -269855.7% -77691.7%
ROA 12-point trend, +179.1% 28.4% 23.4% -9.2% -33.5% -22.6% -36.0% -35.5% -53.0% -61.2% -69.3% -60.1% -35.9%
ROE 12-point trend, +201.4% 38.1% 34.6% -15.4% -52.3% -30.3% -43.9% -33.9% -69.8% -67.8% -75.6% -64.6% -37.6%
ROIC 11-point trend, +129.1% 24.0% 27.6% -20.4% -56.5% -31.6% -45.8% -35.4% -51.9% -87.5% -52.9% -82.6% ·
Liquidité et Solvabilité 2
Données annuelles Liquidité et Solvabilité pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Current Ratio 12-point trend, -81.3% 3.8 2.4 2.4 4.0 6.4 6.8 10.2 8.8 7.6 12.9 10.0 20.5
Quick Ratio 12-point trend, -72.4% 1.1 1.1 1.1 1.4 2.2 3.5 3.0 2.7 1.8 4.0 4.7 3.9
Efficacité 3
Données annuelles Efficacité pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Asset Turnover 12-point trend, +155640.0% 0.8 1.0 1.1 0.8 0.7 0.6 0.5 0.5 0.3 0.0 0.0 0.0
Inventory Turnover 9-point trend, -40.5% 0.9 1.2 1.6 0.8 0.9 1.3 2.2 · 1.9 1.5 · ·
Receivables Turnover 10-point trend, +65.7% 9.7 9.7 9.1 8.2 8.6 10.5 11.0 10.3 10.7 5.9 · ·
Par action 5
Données annuelles Par action pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Book Value / Share 12-point trend, +133.0% $7.21 $4.40 $2.62 $2.47 $3.36 $3.93 $4.50 $3.33 $2.69 $4.27 $1.96 $3.09
Revenue / Share 4-point trend, -99.8% $6.31 $5.76 $4434.39 $3199.07 · · · · · · · ·
Cash Flow / Share 4-point trend, +100.1% $0.65 $0.95 $101.95 $-705.30 · · · · · · · ·
Cash / Share 12-point trend, +68.8% $1.04 $1.92 $1.15 $0.71 $0.92 $2.04 $1.22 $0.94 $0.56 $1.35 $1.00 $0.62
EPS (TTM) 6-point trend, +228.5% $2.30 $1.36 $-0.37 $-1.34 $-1.05 $-1.79 · · · · · ·
Taux de croissance 5
Données annuelles Taux de croissance pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +23.6% 11.9% 31.9% 40.5% 6.8% 9.6% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +52.4% 27.5% 25.5% 18.0% · · · · · · · · ·
Revenue CAGR 5Y 19.4% · · · · · · · · · · ·
EPS YoY 69.1% · · · · · · · · · · ·
Net Income YoY 72.7% · · · · · · · · · · ·
Valorisation (TTM) 10
Données annuelles Valorisation (TTM) pour ACAD
Métrique Tendance 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +892820.8% $1.07B $958M $726M $517M $484M $442M $339M $224M $125M $17M $61.0K $120.0K
Net Income TTM 12-point trend, +522.8% $391M $226M $-61M $-216M $-168M $-282M $-235M $-245M $-289M $-271M $-164M $-92M
Market Cap 12-point trend, +43.2% $4.55B $3.06B $5.16B $2.58B $3.76B $8.53B $6.64B $2.33B $3.75B $3.50B $3.63B $3.18B
P/E 6-point trend, +138.9% 11.6 13.5 -84.6 -11.9 -22.2 -29.9 · · · · · ·
P/S 12-point trend, -100.0% 4.2 3.2 7.1 5.0 7.8 19.3 19.6 10.4 30.0 202.0 59575.7 26470.9
P/B 12-point trend, -63.9% 3.7 4.2 11.9 6.4 6.9 13.6 9.5 4.9 11.2 6.8 18.2 10.3
P / Tangible Book 6-point trend, -70.2% 4.1 5.0 14.1 6.4 6.9 13.6 · · · · · ·
P / Cash Flow 12-point trend, +186.6% 41.4 19.4 308.7 -22.6 -29.9 -62.7 -44.0 -13.9 -17.2 -16.6 -29.8 -47.8
P / FCF 12-point trend, +190.7% 43.3 19.5 309.6 -22.6 -29.6 -59.4 -43.6 -13.7 -17.1 -16.5 -29.3 -47.7
Earnings Yield 6-point trend, +357.0% 8.6% 7.4% -1.2% -8.4% -4.5% -3.4% · · · · · ·

États financiers Compte de résultat, bilan, flux de trésorerie — annuel, sur les 5 dernières années

Compte de résultat
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenu $1.07B$958M$726M$517M$484M
Marge Brute % 94.3%98.0%97.8%
Marge d'exploitation % 9.8%24.1%-10.1%-43.2%-35.2%
Résultat net $391M$226M$-61M$-216M$-168M
BPA dilué $2.30$1.36$-0.37$-1.34$-1.05
Bilan
2025-12-312024-12-312023-12-312022-12-312021-12-31
Ratio de liquidité 3.82.42.44.06.4
Ratio de liquidité réduite 1.11.11.11.42.2
Flux de trésorerie
2025-12-312024-12-312023-12-312022-12-312021-12-31
Flux de trésorerie libre $105M$157M$17M$-114M$-127M

Dernières actualités Actualités récentes mentionnant cette entreprise

Signaux de trading Signaux d'achat/vente récents avec prix d'entrée et ratio risque/récompense

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Détenteurs institutionnels (13F) 388 déclarants · $3.3B total · Au 30 juin 2026

Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.

Activité institutionnelle — Q2 2026 vs trimestre précédent
Nouvelles positions Positions clôturées Augmenté Diminué Variation nette des actions
56 (+10 vs T. préc.) 37 (+10 vs T. préc.) 136 (+11 vs T. préc.) 100 (-13 vs T. préc.) +17.3M

Comparé à Q1 2026. Les dépôts de formulaire 13F de la SEC sont dus dans les 45 jours suivant la fin du trimestre, plus une courte période tampon pour les déposants tardifs — les trimestres encore dans cette fenêtre sont ignorés au profit de la paire la plus récente entièrement déclarée.

Institution Valeur Actions % de 13F suivies Type
BAKER BROS. ADVISORS LP $1 085 696 471 42 912 904 32,71% Actions
STATE STREET CORP $229 628 164 9 076 212 6,92% Actions
VANGUARD PORTFOLIO MANAGEMENT LLC $223 612 785 8 838 450 6,74% Actions
RTW INVESTMENTS, LP $180 756 457 7 144 524 5,45% Actions
VANGUARD CAPITAL MANAGEMENT LLC $145 822 875 5 763 750 4,39% Actions
DIMENSIONAL FUND ADVISORS LP $88 971 384 3 516 656 2,68% Actions
GEODE CAPITAL MANAGEMENT, LLC $73 088 127 2 888 204 2,20% Actions
Palo Alto Investors LP $72 461 629 2 864 096 2,18% Actions
Qube Research & Technologies Ltd $61 899 233 2 446 610 1,86% Actions
Point72 Asset Management, L.P. $61 559 150 2 433 168 1,85% Actions
CITADEL ADVISORS LLC $53 414 195 2 111 233 1,61% Actions
Pictet Asset Management Holding SA $50 146 450 1 983 198 1,51% Actions
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $49 826 959 1 969 445 1,50% Actions
MARSHALL WACE, LLP $44 649 289 1 764 794 1,35% Actions
BRAIDWELL LP $41 653 895 1 646 399 1,25% Actions
NORGES BANK $41 069 692 1 623 308 1,24% Actions
Frazier Life Sciences Management, L.P. $36 386 409 1 438 198 1,10% Actions
Artisan Partners Limited Partnership $33 525 890 1 325 134 1,01% Actions
RENAISSANCE TECHNOLOGIES LLC $32 449 679 1 282 596 0,98% Actions
GOLDMAN SACHS GROUP INC $32 070 584 1 267 612 0,97% Actions
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $30 520 301 1 206 336 0,92% Actions
D. E. Shaw & Co., Inc. $28 330 257 1 119 773 0,85% Actions
Allspring Global Investments Holdings, LLC $26 143 513 1 037 441 0,79% Actions
TWO SIGMA INVESTMENTS, LP $23 452 898 926 992 0,71% Actions
VANGUARD FIDUCIARY TRUST CO $23 082 961 912 370 0,70% Actions
BANK OF AMERICA CORP /DE/ $21 702 062 857 789 0,65% Actions
PANAGORA ASSET MANAGEMENT INC $17 985 922 710 906 0,54% Actions
Fisher Asset Management, LLC $17 690 535 699 230 0,53% Actions
Allianz Asset Management GmbH $15 730 341 706 664 0,47% Actions
RICE HALL JAMES & ASSOCIATES, LLC $15 657 841 618 887 0,47% Actions
MILLENNIUM MANAGEMENT LLC $14 925 077 589 924 0,45% Actions
MANUFACTURERS LIFE INSURANCE COMPANY, THE $14 771 456 583 852 0,45% Actions
ADAGE CAPITAL PARTNERS GP, L.L.C. $12 903 000 510 000 0,39% Actions
Hudson Bay Capital Management LP $11 764 500 465 000 0,35% Actions
GLENMEDE TRUST CO NA $11 656 544 460 733 0,35% Actions
JUPITER ASSET MANAGEMENT LTD $11 599 190 458 466 0,35% Actions
Public Sector Pension Investment Board $11 014 988 435 375 0,33% Actions
MACKENZIE FINANCIAL CORP $10 646 872 420 825 0,32% Actions
Ishara Investments LP $10 373 000 410 000 0,31% Actions
TWO SIGMA ADVISERS, LP $9 888 042 370 200 0,30% Actions
Balyasny Asset Management L.P. $9 817 007 388 024 0,30% Actions
BlackRock, Inc. $9 281 482 366 857 0,28% Actions
SPHERA FUNDS MANAGEMENT LTD. $9 020 310 356 534 0,27% Actions
AMERIPRISE FINANCIAL INC $8 039 177 317 754 0,24% Actions
PRUDENTIAL FINANCIAL INC $7 985 313 315 625 0,24% Actions
Alyeska Investment Group, L.P. $7 850 261 310 287 0,24% Actions
RHUMBLINE ADVISERS $7 663 389 302 902 0,23% Actions
Schonfeld Strategic Advisors LLC $7 189 171 284 157 0,22% Actions
Edgestream Partners, L.P. $7 167 515 283 301 0,22% Actions
Logos Global Management LP $6 325 000 250 000 0,19% Actions
LAZARD ASSET MANAGEMENT LLC $6 263 496 247 569 0,19% Actions
FMR LLC $6 052 317 239 222 0,18% Actions
Swiss National Bank $5 841 871 230 904 0,18% Actions
VICTORY CAPITAL MANAGEMENT INC $5 432 213 214 712 0,16% Actions
ALPS ADVISORS INC $4 985 340 197 049 0,15% Actions
ENVESTNET ASSET MANAGEMENT INC $4 926 239 194 713 0,15% Actions
Legal & General Group Plc $4 918 245 194 397 0,15% Actions
FIRST TRUST ADVISORS LP $4 664 965 184 386 0,14% Actions
NEW YORK STATE COMMON RETIREMENT FUND $4 364 807 172 522 0,13% Actions
Birchview Capital, LP $4 326 300 171 000 0,13% Actions
MARTINGALE ASSET MANAGEMENT L P $4 247 693 167 893 0,13% Actions
Tetragon Partners GP Ltd $4 247 238 167 875 0,13% Actions
GREAT LAKES ADVISORS, LLC $3 822 526 151 088 0,12% Actions
AMERICAN CENTURY COMPANIES INC $3 635 306 143 688 0,11% Actions
STEMPOINT CAPITAL LP $3 622 125 143 167 0,11% Actions
ALLIANCEBERNSTEIN L.P. $3 585 329 161 066 0,11% Actions
Squarepoint Ops LLC $3 542 329 140 013 0,11% Actions
ORBIMED ADVISORS LLC $3 466 100 137 000 0,10% Actions
Erste Asset Management GmbH $3 369 240 133 700 0,10% Actions
Emerald Investment Advisers, LLC $3 333 326 131 752 0,10% Actions
Caption Management, LLC $3 289 000 130 000 0,10% Option de vente
VANGUARD ASSET MANAGEMENT, Ltd $3 130 217 123 724 0,09% Actions
WELLS FARGO & COMPANY/MN $3 084 475 121 916 0,09% Actions
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3 077 311 138 244 0,09% Actions
Longaeva Partners L.P. $2 968 145 117 318 0,09% Actions
JACOBS LEVY EQUITY MANAGEMENT, INC $2 948 791 116 553 0,09% Actions
Trexquant Investment LP $2 935 357 116 022 0,09% Actions
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $2 909 778 115 011 0,09% Actions
JONES FINANCIAL COMPANIES LLLP $2 868 477 113 289 0,09% Actions
Rafferty Asset Management, LLC $2 789 426 110 254 0,08% Actions
Nan Fung Group Holdings Ltd $2 605 495 102 984 0,08% Actions
RAYMOND JAMES FINANCIAL INC $2 406 232 95 108 0,07% Actions
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $2 344 000 92 648 0,07% Actions
ROYCE & ASSOCIATES LP $2 324 691 91 885 0,07% Actions
HOHIMER WEALTH MANAGEMENT, LLC $2 322 540 91 800 0,07% Actions
Point72 Europe (London) LLP $2 305 047 108 015 0,07% Actions
VIRGINIA RETIREMENT SYSTEMS ET Al $2 134 076 79 898 0,06% Actions
Campbell & CO Investment Adviser LLC $2 108 527 83 341 0,06% Actions
Verdad Advisers, LP $2 090 514 82 629 0,06% Actions
VOYA INVESTMENT MANAGEMENT LLC $2 072 576 81 920 0,06% Actions
CITADEL ADVISORS LLC $2 049 300 81 000 0,06% Option d'achat
GUGGENHEIM CAPITAL LLC $1 979 776 78 252 0,06% Actions
WESBANCO BANK INC $1 978 460 78 200 0,06% Actions
Phocas Financial Corp. $1 954 299 77 245 0,06% Actions
MetLife Investment Management, LLC $1 899 043 75 061 0,06% Actions
STATE OF WISCONSIN INVESTMENT BOARD $1 850 493 73 142 0,06% Actions
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1 788 331 70 685 0,05% Actions
Freestone Grove Partners LP $1 755 643 69 393 0,05% Actions
CenterBook Partners LP $1 743 878 68 928 0,05% Actions
CANADA PENSION PLAN INVESTMENT BOARD $1 722 930 68 100 0,05% Actions

Initiés de la société 37 initiés · 19 dirigeants · 19 administrateurs

Dirigeant Rôle Dernière activité Actions détenues Achats 12m Ventes 12m Net 12m
Stephen Davis CEO 6 janvier 2024 M 96 521 0 0 $0
Uli Hacksell CEO 25 mars 2011 A 69 916 0 0 $0
Elena Ridloff EVP and CFO 29 avril 2021 M 10 553 0 0 $0
Todd S. Young EVP AND CFO 15 octobre 2018 A 0 0 $0
Thomas H Aasen Exec. VP, CFO & CBO 25 mars 2011 A 13 899 0 0 $0
Srdjan R. Stankovic President 21 novembre 2022 M 61 234 0 0 $0
Mark R Brann President & CSO 16 juin 2006 S 317 756 0 0 $0
Brendan Teehan EVP, COO, Head of Commercial 6 janvier 2024 M 30 949 0 0 $0
Elizabeth H.Z. Thompson EVP, Head of Research & Dev 29 juillet 2026 M 18 994 0 2 $-432 662
James Kihara PRINCIPAL ACCOUNTING OFFICER 26 juin 2026 S 13 088 0 2 $-412 253
Austin D. Kim EVP,General Counsel, Secretary 6 janvier 2024 M 46 901 0 0 $0
Douglas J Williamson Executive VP, Research & Dev 10 février 2023 A 0 0 $0
Michael J. Yang EVP and CCO 6 janvier 2021 M 8 059 0 0 $0
Eric Alejandro Miller Controller & PAO 15 octobre 2019 M 270 0 0 $0
Glenn Baity VP, GC & Sec. 25 mars 2011 A 0 0 $0
Roger Mills Executive VP, Development 25 mars 2011 A 0 0 $0
Bo-Ragnar Tolf VP/Mg. Dir. ACADIA Pharma AB 8 juillet 2009 M 20 000 0 0 $0
Brian Lundstrom Sr. VP, Bus. Development 7 mars 2008 A 0 0 0 $0
Robert E Davis Exec. VP, Drug Discovery 11 mars 2005 A 0 0 $0
Adora Ndu Administrateur 29 mai 2026 A 32 908 0 0 $0
Elizabeth A. Garofalo Administrateur 29 mai 2026 A 33 489 0 0 $0
Jonathan Poole Administrateur 29 mai 2026 A 2 010 0 0 $0
James M Daly Administrateur 29 mai 2026 A 12 148 0 0 $0
Laura Brege Administrateur 29 mai 2026 A 23 202 0 0 $0
Edmund Harrigan Administrateur 29 mai 2026 A 43 148 0 0 $0
Daniel B Soland Administrateur 1 juin 2023 A 28 002 0 0 $0
Torsten Rasmussen Administrateur 11 juin 2010 A 4 000 0 0 $0
Leslie L Iversen Administrateur 11 juin 2010 A 9 000 0 0 $0
Mary Ann Gray Administrateur 11 juin 2010 A 0 0 $0
Michael T Borer Administrateur 11 juin 2010 A 0 0 $0
Lester J Ph D Kaplan Administrateur 11 juin 2010 A 4 000 0 0 $0
Gordon M Binder Administrateur 12 juin 2009 A 14 364 0 0 $0
Alan G Walton Administrateur 12 juin 2009 A 25 979 0 0 $0
Martien Van Osch Administrateur 10 juin 2005 A 1 168 892 0 0 $0
GORDON CARL L Administrateur 20 avril 2005 A 774 006 0 0 $0
Mark C. Schneyer 6 août 2026 M 67 828 0 3 $-587 248
John Joseph Kaiser 20 octobre 2008 A 0 0 $0

Initiés issus des déclarations SEC Form 3/4/5 ; net = uniquement P/S de marché

Activistes et détenteurs de 5%+ 6 participations

Investisseurs ayant déposé un Schedule 13D auprès de la SEC — détention effective supérieure à 5% avec l'intention d'influencer l'émetteur (participations activistes, campagnes pour le conseil d'administration, fusions-acquisitions). Chaque ligne montre le dernier état connu de la position du déposant.

Déclarant Déposé Participation Statut Objectif Dépôt
Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker, FBB3 LLC ×14 dépôts 26 février 2026 25,40% Amendement SEC
Baker Bros. Advisors, LLC, Felix J. Baker, Julian C. Baker ×4 dépôts 6 juin 2013 Dépôt initial SEC
Personne déclarante non divulguée, Personne déclarante non divulguée, Personne déclarante non divulguée 2 mai 2005 Dépôt initial SEC
Personne déclarante non divulguée, Personne déclarante non divulguée, Personne déclarante non divulguée 2 mai 2005 Dépôt initial SEC
Personne déclarante non divulguée, Personne déclarante non divulguée, Personne déclarante non divulguée 2 mai 2005 Dépôt initial SEC
Oxford Bioscience Partners IV L.P., mRNA Fund II L.P., OBP Management IV L.P., Jeffrey T. Barnes, Mark P. Carthy, Jonathan J. Fleming, Michael E. Lytton, Alan G. Walton 29 avril 2005 Dépôt initial Investissement passif SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Détention d'ETF Détenu par 77 ETFs

Le poids reflète uniquement les participations directes en actions (N-PORT) ; les fonds à effet de levier ou basés sur des dérivés peuvent détenir une exposition supplémentaire aux swaps non indiquée.

Fonds Poids Unités Au Source
IBRN · iShares Trust 4,89% 13 265 SH 8 août 2026 Quotidien
PBE · Invesco Exchange-Traded Fund Trust 3,29% 407 914 SH 8 août 2026 Quotidien
SBIO · ALPS ETF Trust 2,35% 175 740 NS 31 mai 2026 N-PORT
PSCH · Invesco Exchange-Traded Fund Trust … 1,87% 109 972 SH 8 août 2026 Quotidien
BBP · ETFis Series Trust I 1,32% 34 855 NS 30 avril 2026 N-PORT
RZG · Invesco Exchange-Traded Fund Trust 1,25% 59 514 SH 8 août 2026 Quotidien
LABU · Direxion Shares ETF Trust 0,85% 195 542 NS 30 avril 2026 N-PORT
ROSC · Lattice Strategies Trust 0,56% 13 607 NS 30 avril 2026 N-PORT
IJT · iShares Trust 0,40% 1 176 933 SH 8 août 2026 Quotidien
OASC · Unified Series Trust 0,39% 15 269 NS 31 mai 2026 N-PORT
IBB · iShares Trust 0,37% 1 239 145 SH 8 août 2026 Quotidien
VIOG · VANGUARD ADMIRAL FUNDS 0,35% 150 827 SH 8 août 2026 Quotidien
IBBQ · Invesco Exchange-Traded Fund Trust … 0,34% 9 317 SH 8 août 2026 Quotidien
FNY · First Trust Exchange-Traded AlphaDE… 0,27% 61 606 NS 30 avril 2026 N-PORT
BFOR · ALPS ETF Trust 0,24% 24 003 NS 31 mai 2026 N-PORT
QVMS · Invesco Exchange-Traded Fund Trust … 0,23% 20 369 SH 8 août 2026 Quotidien
IWO · iShares Trust 0,23% 1 166 817 SH 8 août 2026 Quotidien
XJR · iShares Trust 0,23% 14 974 SH 8 août 2026 Quotidien
GSSC · Goldman Sachs ETF Trust 0,20% 89 945 NS 31 mai 2026 N-PORT
IJR · iShares Trust 0,20% 7 728 433 SH 8 août 2026 Quotidien
VTWG · VANGUARD SCOTTSDALE FUNDS 0,19% 137 860 SH 8 août 2026 Quotidien
BIB · ProShares Trust 0,19% 6 303 NS 31 mai 2026 N-PORT
VIOO · VANGUARD ADMIRAL FUNDS 0,17% 443 221 SH 8 août 2026 Quotidien
BKSE · BNY Mellon ETF Trust 0,17% 6 035 NS 30 avril 2026 N-PORT
SMMV · iShares Trust 0,17% 17 063 SH 8 août 2026 Quotidien
SMLF · iShares Trust 0,15% 219 745 SH 8 août 2026 Quotidien
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0,15% 47 683 NS 30 avril 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0,14% 137 072 SH 8 août 2026 Quotidien
FNX · First Trust Exchange-Traded AlphaDE… 0,14% 81 552 NS 30 avril 2026 N-PORT
SAA · ProShares Trust 0,12% 1 498 NS 31 mai 2026 N-PORT
IWM · iShares Trust 0,12% 3 281 125 SH 8 août 2026 Quotidien
ISCG · iShares Trust 0,11% 39 884 SH 8 août 2026 Quotidien
VTWO · VANGUARD SCOTTSDALE FUNDS 0,10% 741 237 SH 8 août 2026 Quotidien
RWJ · Invesco Exchange-Traded Fund Trust … 0,09% 66 331 SH 8 août 2026 Quotidien
VBK · VANGUARD INDEX FUNDS 0,09% 1 699 377 SH 8 août 2026 Quotidien
AVSC · AMERICAN CENTURY ETF TRUST 0,09% 115 210 NS 31 mai 2026 N-PORT
DFAS · Dimensional ETF Trust 0,08% 526 641 NS 30 avril 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0,08% 16 957 NS 30 avril 2026 N-PORT
ITWO · ProShares Trust 0,07% 5 921 NS 31 mai 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0,06% 599 784 NS 31 mai 2026 N-PORT
ISCB · iShares Trust 0,06% 5 636 SH 8 août 2026 Quotidien
FHLC · FIDELITY COVINGTON TRUST 0,04% 54 956 NS 30 avril 2026 N-PORT
IEUS · iShares Trust 0,04% 7 411 SH 8 août 2026 Quotidien
SMDX · Tidal Trust III 0,04% 2 306 NS 30 avril 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0,04% 4 033 SH 8 août 2026 Quotidien
UWM · ProShares Trust 0,04% 4 631 NS 31 mai 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0,04% 1 457 036 SH 8 août 2026 Quotidien
VB · VANGUARD INDEX FUNDS 0,04% 2 944 095 SH 8 août 2026 Quotidien
PDN · Invesco Exchange-Traded Fund Trust … 0,04% 14 209 SH 8 août 2026 Quotidien
VHT · VANGUARD WORLD FUND 0,04% 346 329 SH 8 août 2026 Quotidien