| FMR LLC |
$357,981,753 |
4,894,473 |
11.37% |
주식
|
| BlackRock, Inc. |
$180,502,133 |
2,467,899 |
5.73% |
주식
|
| RA CAPITAL MANAGEMENT, L.P. |
$179,209,164 |
2,450,221 |
5.69% |
주식
|
| VANGUARD GROUP INC |
$140,371,470 |
1,767,680 |
4.46% |
주식
|
| JPMORGAN CHASE & CO |
$139,868,053 |
1,875,795 |
4.44% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$127,362,413 |
1,741,351 |
4.05% |
주식
|
| STATE STREET CORP |
$120,595,865 |
1,648,836 |
3.83% |
주식
|
| Vestal Point Capital, LP |
$113,367,000 |
1,550,000 |
3.60% |
주식
|
| Atlas Venture Life Science Advisors, LLC |
$110,724,818 |
1,513,875 |
3.52% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$100,130,635 |
1,369,027 |
3.18% |
주식
|
| Frazier Life Sciences Management, L.P. |
$99,093,875 |
1,354,852 |
3.15% |
주식
|
| TCG Crossover Management, LLC |
$98,143,787 |
1,341,862 |
3.12% |
주식
|
| BVF INC/IL |
$84,375,182 |
1,153,612 |
2.68% |
주식
|
| Woodline Partners LP |
$70,088,672 |
958,281 |
2.23% |
주식
|
| Siren, L.L.C. |
$64,977,649 |
888,401 |
2.06% |
주식
|
| Logos Global Management LP |
$63,997,500 |
875,000 |
2.03% |
주식
|
| Opaleye Management Inc. |
$62,534,700 |
855,000 |
1.99% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$57,772,342 |
789,724 |
1.84% |
주식
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$48,052,980 |
657,000 |
1.53% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$41,622,451 |
569,018 |
1.32% |
주식
|
| Bellevue Group AG |
$40,958,400 |
560,000 |
1.30% |
주식
|
| Saturn V Capital Management LP |
$38,378,752 |
524,730 |
1.22% |
주식
|
| ARMISTICE CAPITAL, LLC |
$33,644,400 |
460,000 |
1.07% |
주식
|
| JENNISON ASSOCIATES LLC |
$32,146,492 |
439,520 |
1.02% |
주식
|
| Aberdeen Group plc |
$32,048,046 |
438,174 |
1.02% |
주식
|
| Palo Alto Investors LP |
$30,473,488 |
416,646 |
0.97% |
주식
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$28,938,480 |
395,651 |
0.92% |
주식
|
| Pictet Asset Management Holding SA |
$28,186,328 |
385,375 |
0.90% |
주식
|
| Assenagon Asset Management S.A. |
$28,097,316 |
384,158 |
0.89% |
주식
|
| LOOMIS SAYLES & CO L P |
$27,929,533 |
381,864 |
0.89% |
주식
|
| Foresite Capital Management V, LLC |
$27,359,407 |
374,069 |
0.87% |
주식
|
| ORBIMED ADVISORS LLC |
$26,150,110 |
357,535 |
0.83% |
주식
|
| BAKER BROS. ADVISORS LP |
$25,573,913 |
349,657 |
0.81% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20,620,872 |
281,937 |
0.66% |
주식
|
| Octagon Capital Advisors LP |
$19,747,800 |
270,000 |
0.63% |
주식
|
| NORTHERN TRUST CORP |
$19,381,368 |
264,990 |
0.62% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$18,824,919 |
257,382 |
0.60% |
주식
|
| Checkpoint Capital L.P. |
$17,562,743 |
240,125 |
0.56% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$16,470,982 |
225,198 |
0.52% |
주식
|
| CITADEL ADVISORS LLC |
$15,308,787 |
209,308 |
0.49% |
주식
|
| Bank of New York Mellon Corp |
$14,973,763 |
204,727 |
0.48% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$13,508,592 |
184,695 |
0.43% |
주식
|
| Catalio Capital Management, LP |
$11,657,346 |
159,384 |
0.37% |
주식
|
| Caption Management, LLC |
$10,971,000 |
150,000 |
0.35% |
콜 옵션
|
| Sofinnova Investments, Inc. |
$10,695,920 |
146,239 |
0.34% |
주식
|
| Bain Capital Life Sciences Investors, LLC |
$10,329,855 |
141,234 |
0.33% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$10,001,895 |
136,750 |
0.32% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$9,882,018 |
135,111 |
0.31% |
주식
|
| Alyeska Investment Group, L.P. |
$9,142,500 |
125,000 |
0.29% |
주식
|
| Ensign Peak Advisors, Inc |
$8,931,199 |
122,111 |
0.28% |
주식
|
| UBS Group AG |
$8,116,419 |
110,971 |
0.26% |
주식
|
| Trexquant Investment LP |
$7,877,105 |
107,699 |
0.25% |
주식
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$7,809,085 |
106,769 |
0.25% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$7,770,979 |
106,248 |
0.25% |
주식
|
| GOLDMAN SACHS GROUP INC |
$7,122,593 |
97,383 |
0.23% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$7,090,307 |
110,890 |
0.23% |
주식
|
| MORGAN STANLEY |
$6,699,315 |
91,595 |
0.21% |
주식
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$6,055,992 |
82,800 |
0.19% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$5,703,384 |
77,980 |
0.18% |
주식
|
| Squarepoint Ops LLC |
$5,549,278 |
75,872 |
0.18% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5,383,104 |
73,600 |
0.17% |
콜 옵션
|
| DNB Asset Management AS |
$5,348,509 |
73,127 |
0.17% |
주식
|
| Casdin Capital, LLC |
$4,754,100 |
65,000 |
0.15% |
주식
|
| SPHERA FUNDS MANAGEMENT LTD. |
$4,647,169 |
63,538 |
0.15% |
주식
|
| Nuveen, LLC |
$4,414,511 |
60,357 |
0.14% |
주식
|
| PEAK6 LLC |
$4,388,400 |
60,000 |
0.14% |
콜 옵션
|
| KVP Capital Advisors, LP |
$4,260,405 |
58,250 |
0.14% |
주식
|
| MOORE CAPITAL MANAGEMENT, LP |
$4,227,199 |
57,796 |
0.13% |
주식
|
| XTX Topco Ltd |
$4,147,769 |
56,710 |
0.13% |
주식
|
| NEXTBio Capital Management LP |
$3,851,187 |
52,655 |
0.12% |
주식
|
| ALGERT GLOBAL LLC |
$3,792,309 |
51,850 |
0.12% |
주식
|
| ExodusPoint Capital Management, LP |
$3,775,706 |
51,623 |
0.12% |
주식
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$3,725,000 |
50,000 |
0.12% |
주식
|
| Burkehill Global Management, LP |
$3,657,000 |
50,000 |
0.12% |
주식
|
| Brevan Howard Capital Management LP |
$3,656,707 |
49,996 |
0.12% |
주식
|
| Swiss National Bank |
$3,642,372 |
49,800 |
0.12% |
주식
|
| AMERIPRISE FINANCIAL INC |
$3,355,224 |
45,874 |
0.11% |
주식
|
| Atle Fund Management AB |
$3,194,901 |
43,682 |
0.10% |
주식
|
| Quadrature Capital Ltd |
$3,102,526 |
42,419 |
0.10% |
주식
|
| Invesco Ltd. |
$3,076,049 |
42,057 |
0.10% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2,878,790 |
39,360 |
0.09% |
주식
|
| ALPS ADVISORS INC |
$2,820,644 |
38,565 |
0.09% |
주식
|
| CITIGROUP INC |
$2,802,506 |
38,317 |
0.09% |
주식
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$2,798,483 |
38,262 |
0.09% |
주식
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$2,679,411 |
36,634 |
0.09% |
주식
|
| RHUMBLINE ADVISERS |
$2,621,620 |
35,844 |
0.08% |
주식
|
| LAZARD ASSET MANAGEMENT LLC |
$2,562,387 |
35,034 |
0.08% |
주식
|
| SEVEN GRAND MANAGERS, LLC |
$2,559,900 |
35,000 |
0.08% |
주식
|
| MARSHALL WACE, LLP |
$2,515,577 |
34,394 |
0.08% |
주식
|
| Jump Financial, LLC |
$2,380,634 |
32,549 |
0.08% |
주식
|
| BANK OF MONTREAL /CAN/ |
$2,363,007 |
32,308 |
0.08% |
주식
|
| DEUTSCHE BANK AG\ |
$2,241,229 |
30,643 |
0.07% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$2,216,800 |
34,670 |
0.07% |
주식
|
| RTW INVESTMENTS, LP |
$2,194,200 |
30,000 |
0.07% |
주식
|
| Squadron Capital Management LLC |
$2,194,200 |
30,000 |
0.07% |
콜 옵션
|
| VICTORY CAPITAL MANAGEMENT INC |
$2,129,618 |
29,117 |
0.07% |
주식
|
| WELLS FARGO & COMPANY/MN |
$2,115,464 |
28,924 |
0.07% |
주식
|
| TUDOR INVESTMENT CORP ET AL |
$2,096,412 |
28,663 |
0.07% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2,031,171 |
27,771 |
0.06% |
주식
|
| Y-Intercept (Hong Kong) Ltd |
$1,966,588 |
26,888 |
0.06% |
주식
|
| Rafferty Asset Management, LLC |
$1,943,037 |
26,566 |
0.06% |
주식
|
| Campbell & CO Investment Adviser LLC |
$1,870,044 |
25,568 |
0.06% |
주식
|
| PNC Financial Services Group, Inc. |
$1,633,435 |
22,333 |
0.05% |
주식
|
| TD Asset Management Inc |
$1,579,824 |
21,600 |
0.05% |
주식
|
| Engineers Gate Manager LP |
$1,430,033 |
19,552 |
0.05% |
주식
|
| BARCLAYS PLC |
$1,368,450 |
18,710 |
0.04% |
주식
|
| Legal & General Group Plc |
$1,350,019 |
18,458 |
0.04% |
주식
|
| DLD Asset Management, LP |
$1,330,238 |
18,200 |
0.04% |
풋 옵션
|
| CITADEL ADVISORS LLC |
$1,258,008 |
17,200 |
0.04% |
풋 옵션
|
| MetLife Investment Management, LLC |
$1,213,246 |
16,588 |
0.04% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1,182,775 |
16,114 |
0.04% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1,178,359 |
16,111 |
0.04% |
주식
|
| JANE STREET GROUP, LLC |
$1,171,045 |
16,011 |
0.04% |
주식
|
| CITADEL ADVISORS LLC |
$1,155,612 |
15,800 |
0.04% |
콜 옵션
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1,128,477 |
15,429 |
0.04% |
주식
|
| Man Group plc |
$1,091,615 |
14,925 |
0.03% |
주식
|
| HighVista Strategies LLC |
$1,039,978 |
14,219 |
0.03% |
주식
|
| PROFUND ADVISORS LLC |
$988,048 |
13,509 |
0.03% |
주식
|
| Ikarian Capital, LLC |
$972,762 |
13,300 |
0.03% |
콜 옵션
|
| Ikarian Capital, LLC |
$972,762 |
13,300 |
0.03% |
풋 옵션
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$948,699 |
12,971 |
0.03% |
주식
|
| Qube Research & Technologies Ltd |
$933,120 |
12,758 |
0.03% |
주식
|
| SEI INVESTMENTS CO |
$925,008 |
12,647 |
0.03% |
주식
|
| MARTINGALE ASSET MANAGEMENT L P |
$878,339 |
12,009 |
0.03% |
주식
|
| Vanguard Global Advisers, LLC |
$848,205 |
11,597 |
0.03% |
주식
|
| JANUS HENDERSON GROUP PLC |
$739,462 |
11,555 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$736,959 |
10,076 |
0.02% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$721,745 |
9,868 |
0.02% |
주식
|
| JANE STREET GROUP, LLC |
$665,574 |
9,100 |
0.02% |
콜 옵션
|
| Entropy Technologies, LP |
$614,961 |
8,408 |
0.02% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$610,353 |
8,345 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$602,600 |
8,239 |
0.02% |
주식
|
| Lion Point Capital, LP |
$592,434 |
8,100 |
0.02% |
주식
|
| Russell Investments Group, Ltd. |
$591,190 |
8,083 |
0.02% |
주식
|
| State of New Jersey Common Pension Fund D |
$586,583 |
8,020 |
0.02% |
주식
|
| PSP Research LLC |
$585,120 |
8,000 |
0.02% |
주식
|
| Cubist Systematic Strategies, LLC |
$575,848 |
8,714 |
0.02% |
주식
|
| Quantinno Capital Management LP |
$533,703 |
7,297 |
0.02% |
주식
|
| JANE STREET GROUP, LLC |
$526,608 |
7,200 |
0.02% |
풋 옵션
|
| ARIZONA STATE RETIREMENT SYSTEM |
$500,570 |
6,844 |
0.02% |
주식
|
| EntryPoint Capital, LLC |
$465,975 |
6,371 |
0.01% |
주식
|
| SummitTX Capital, L.P. |
$461,440 |
6,309 |
0.01% |
주식
|
| Creative Planning |
$457,418 |
6,254 |
0.01% |
주식
|
| INTECH INVESTMENT MANAGEMENT LLC |
$442,790 |
6,054 |
0.01% |
주식
|
| AXQ CAPITAL, LP |
$441,400 |
6,035 |
0.01% |
주식
|
| D. E. Shaw & Co., Inc. |
$440,815 |
6,027 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$435,841 |
5,959 |
0.01% |
주식
|
| Susquehanna Portfolio Strategies, LLC |
$424,797 |
5,808 |
0.01% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$412,510 |
5,640 |
0.01% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$397,150 |
5,430 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$380,328 |
5,200 |
0.01% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$365,700 |
5,000 |
0.01% |
풋 옵션
|
| ProShare Advisors LLC |
$362,701 |
4,959 |
0.01% |
주식
|
| Virtus Investment Advisers, LLC |
$351,950 |
4,812 |
0.01% |
주식
|
| JONES FINANCIAL COMPANIES LLLP |
$345,184 |
4,616 |
0.01% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$338,638 |
4,630 |
0.01% |
주식
|
| Eleva Capital SAS |
$327,053 |
5,115 |
0.01% |
주식
|
| Fiduciary Trust Co |
$296,290 |
4,051 |
0.01% |
주식
|
| AlphaCentric Advisors LLC |
$294,754 |
4,030 |
0.01% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$292,560 |
4,000 |
0.01% |
콜 옵션
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$292,560 |
4,000 |
0.01% |
풋 옵션
|
| E Fund Management Co., Ltd. |
$273,982 |
3,746 |
0.01% |
주식
|
| Bryce Point Capital, LLC |
$258,505 |
3,912 |
0.01% |
주식
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$245,385 |
3,355 |
0.01% |
주식
|
| Jain Global LLC |
$228,928 |
3,130 |
0.01% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$225,417 |
3,082 |
0.01% |
주식
|
| DLD Asset Management, LP |
$219,420 |
3,000 |
0.01% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$213,130 |
2,914 |
0.01% |
주식
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$211,741 |
2,895 |
0.01% |
주식
|
| STRS OHIO |
$197,478 |
2,700 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$187,824 |
2,568 |
0.01% |
주식
|
| Quantbot Technologies LP |
$152,863 |
2,090 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$137,168 |
1,875,399 |
0.00% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$124,923 |
1,708 |
0.00% |
주식
|
| US BANCORP \DE\ |
$89,889 |
1,229 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$73,000 |
989 |
0.00% |
주식
|
| Foresite Capital Management VI LLC |
$70,946 |
970 |
0.00% |
주식
|
| Tower Research Capital LLC (TRC) |
$68,678 |
939 |
0.00% |
주식
|
| CWM, LLC |
$66,178 |
1,035 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$59,170 |
809 |
0.00% |
주식
|
| Allworth Financial LP |
$46,298 |
633 |
0.00% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$41,397 |
566 |
0.00% |
주식
|
| Steward Partners Investment Advisory, LLC |
$38,618 |
528 |
0.00% |
주식
|
| Bayforest Capital Ltd |
$32,986 |
451 |
0.00% |
주식
|
| AlphaQuest LLC |
$29,064 |
366 |
0.00% |
주식
|
| State of Wyoming |
$25,306 |
346 |
0.00% |
주식
|
| GAMMA Investing LLC |
$21,357 |
292 |
0.00% |
주식
|
| Kemnay Advisory Services Inc. |
$19,675 |
269 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$19,602 |
268 |
0.00% |
주식
|
| TORONTO DOMINION BANK |
$14,482 |
198 |
0.00% |
주식
|
| J.Safra Asset Management Corp |
$11,776 |
161 |
0.00% |
주식
|
| Larson Financial Group LLC |
$8,996 |
123 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$7,241 |
99 |
0.00% |
주식
|
| Smartleaf Asset Management LLC |
$6,854 |
92 |
0.00% |
주식
|
| HRT FINANCIAL LP |
$6,642 |
90,822 |
0.00% |
주식
|
| Arax Advisory Partners |
$6,290 |
86 |
0.00% |
주식
|
| CoreCap Advisors, LLC |
$5,705 |
78 |
0.00% |
주식
|
| iA Global Asset Management Inc. |
$4,829 |
66,023 |
0.00% |
주식
|
| Optiver Holding B.V. |
$4,754 |
65 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$3,439 |
47 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$3,273 |
50 |
0.00% |
주식
|
| Lindbrook Capital, LLC |
$2,879 |
58 |
0.00% |
주식
|
| FIRST HORIZON CORP |
$2,633 |
36 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$2,340 |
32 |
0.00% |
주식
|
| Silver Grove Financial Group, Inc. |
$1,902 |
26 |
0.00% |
주식
|
| FIFTH THIRD BANCORP |
$1,844 |
25 |
0.00% |
주식
|
| COMERICA BANK |
$1,544 |
19 |
0.00% |
주식
|
| Parkside Financial Bank & Trust |
$1,462 |
20 |
0.00% |
주식
|
| Quarry LP |
$1,317 |
18 |
0.00% |
주식
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$1,287 |
17,599 |
0.00% |
주식
|
| JPL Wealth Management, LLC |
$1,244 |
17 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$1,243 |
17 |
0.00% |
주식
|
| GSA CAPITAL PARTNERS LLP |
$1,194 |
16,324 |
0.00% |
주식
|
| Geneos Wealth Management Inc. |
$951 |
13 |
0.00% |
주식
|
| HUNTINGTON NATIONAL BANK |
$878 |
12 |
0.00% |
주식
|
| ASSETMARK, INC |
$878 |
12 |
0.00% |
주식
|
| Cornerstone Financial Management LLC |
$805 |
11 |
0.00% |
주식
|
| Bare Financial Services, Inc |
$658 |
9 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$563 |
7,704 |
0.00% |
주식
|
| Keating Financial Advisory Services, Inc. |
$439 |
6 |
0.00% |
주식
|
| Essential Partners LLC |
$366 |
5 |
0.00% |
주식
|
| Virtu Financial LLC |
$343 |
4,694 |
0.00% |
주식
|
| Global Retirement Partners, LLC |
$293 |
4 |
0.00% |
주식
|
| Clearstead Advisors, LLC |
$148 |
2 |
0.00% |
주식
|
| Hughes Financial Services, LLC |
$146 |
2 |
0.00% |
주식
|
| Downshift Financial, LLC |
$146 |
2 |
0.00% |
주식
|
| KBC Group NV |
$74 |
1,011 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$73 |
1 |
0.00% |
주식
|
| Wealth Enhancement Trust Services, Inc. |
$73 |
1 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$73 |
1 |
0.00% |
주식
|
| IFP Advisors, Inc |
$73 |
1 |
0.00% |
주식
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$53 |
730 |
0.00% |
주식
|
| Pacer Advisors, Inc. |
$32 |
444 |
0.00% |
주식
|
| Covestor Ltd |
$1 |
7 |
0.00% |
주식
|
| GW&K Investment Management, LLC |
$1 |
16 |
0.00% |
주식
|