| BlackRock, Inc. |
$62705681 |
30146963 |
9.61% |
股份
|
| Pfizer Inc |
$46928245 |
22032040 |
7.19% |
股份
|
| Frazier Life Sciences Management, L.P. |
$46689069 |
22446668 |
7.16% |
股份
|
| STATE STREET CORP |
$39573718 |
19025826 |
6.07% |
股份
|
| TPG GP A, LLC |
$38929916 |
18716306 |
5.97% |
股份
|
| Sio Capital Management, LLC |
$27712736 |
13323431 |
4.25% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$27296756 |
13123440 |
4.18% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$25306603 |
12166636 |
3.88% |
股份
|
| FMR LLC |
$24978809 |
12009043 |
3.83% |
股份
|
| CITADEL ADVISORS LLC |
$20982562 |
10087770 |
3.22% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$16191444 |
7784348 |
2.48% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$14666040 |
7049328 |
2.25% |
股份
|
| GOLDMAN SACHS GROUP INC |
$12789834 |
6148959 |
1.96% |
股份
|
| VANGUARD GROUP INC |
$12674704 |
9251609 |
1.94% |
股份
|
| GordonMD Global Investments LP |
$11019840 |
5298000 |
1.69% |
股份
|
| MARSHALL WACE, LLP |
$10598449 |
5095408 |
1.62% |
股份
|
| Patient Square Capital LP |
$10504000 |
5050000 |
1.61% |
股份
|
| Aberdeen Group plc |
$10403644 |
5001752 |
1.60% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$10075289 |
4843889 |
1.54% |
股份
|
| D. E. Shaw & Co., Inc. |
$9798329 |
4710735 |
1.50% |
股份
|
| MORGAN STANLEY |
$9380720 |
4509962 |
1.44% |
股份
|
| Woodline Partners LP |
$9361298 |
4500624 |
1.44% |
股份
|
| Candriam S.C.A. |
$9010818 |
4336296 |
1.38% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$8761122 |
4212078 |
1.34% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$7975369 |
3834312 |
1.22% |
股份
|
| Walleye Capital LLC |
$6797465 |
3268012 |
1.04% |
股份
|
| RTW INVESTMENTS, LP |
$6760000 |
3250000 |
1.04% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$6740207 |
3239077 |
1.03% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$6629626 |
3187320 |
1.02% |
股份
|
| UBS Group AG |
$6319855 |
3038392 |
0.97% |
股份
|
| Ghisallo Capital Management LLC |
$6240000 |
3000000 |
0.96% |
股份
|
| NORTHERN TRUST CORP |
$6146986 |
2955282 |
0.94% |
股份
|
| Wildcat Capital Management, LLC |
$6075237 |
2920787 |
0.93% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4730675 |
2274363 |
0.73% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$4173079 |
2006288 |
0.64% |
股份
|
| DAFNA Capital Management LLC |
$4160000 |
2000000 |
0.64% |
股份
|
| TWO SIGMA ADVISERS, LP |
$3959574 |
2890200 |
0.61% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3823756 |
1838344 |
0.59% |
股份
|
| JPMORGAN CHASE & CO |
$3193323 |
1438434 |
0.49% |
股份
|
| Boxer Capital Management, LLC |
$3120000 |
1500000 |
0.48% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$3026614 |
1455103 |
0.46% |
股份
|
| Raiffeisen Bank International AG |
$2442000 |
1100000 |
0.37% |
股份
|
| Vida Ventures Advisors, LLC |
$2229722 |
1798163 |
0.34% |
股份
|
| Invesco Ltd. |
$1607395 |
772786 |
0.25% |
股份
|
| Bank of New York Mellon Corp |
$1512540 |
727182 |
0.23% |
股份
|
| Man Group plc |
$1459954 |
701901 |
0.22% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1412262 |
678972 |
0.22% |
股份
|
| Nuveen, LLC |
$1299268 |
624648 |
0.20% |
股份
|
| IEQ CAPITAL, LLC |
$1207172 |
580371 |
0.19% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$1138153 |
547189 |
0.17% |
股份
|
| CITIGROUP INC |
$1072238 |
515499 |
0.16% |
股份
|
| Voleon Capital Management LP |
$1010092 |
485621 |
0.15% |
股份
|
| AMERIPRISE FINANCIAL INC |
$977321 |
469866 |
0.15% |
股份
|
| TD Asset Management Inc |
$961126 |
462080 |
0.15% |
股份
|
| Russell Investments Group, Ltd. |
$911890 |
438409 |
0.14% |
股份
|
| MACKENZIE FINANCIAL CORP |
$893489 |
429562 |
0.14% |
股份
|
| Creative Planning |
$886989 |
426437 |
0.14% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$886650 |
426274 |
0.14% |
股份
|
| Erste Asset Management GmbH |
$846708 |
381400 |
0.13% |
股份
|
| ALPS ADVISORS INC |
$728630 |
350303 |
0.11% |
股份
|
| Rafferty Asset Management, LLC |
$702073 |
337535 |
0.11% |
股份
|
| Cerity Partners LLC |
$687004 |
330290 |
0.11% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$671480 |
322827 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$644248 |
309741 |
0.10% |
股份
|
| Moloney Securities Asset Management, LLC |
$637360 |
514000 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$586454 |
281949 |
0.09% |
股份
|
| Harold Davidson & Associates Inc. |
$585566 |
281522 |
0.09% |
股份
|
| HSBC HOLDINGS PLC |
$557157 |
259747 |
0.09% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$554147 |
266417 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$551142 |
225878 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$533686 |
256580 |
0.08% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$520000 |
250000 |
0.08% |
股份
|
| Squarepoint Ops LLC |
$502370 |
241524 |
0.08% |
股份
|
| BIT Capital GmbH |
$478400 |
230000 |
0.07% |
股份
|
| LPL Financial LLC |
$458994 |
220670 |
0.07% |
股份
|
| BARCLAYS PLC |
$457015 |
219718 |
0.07% |
股份
|
| Vanguard Global Advisers, LLC |
$447585 |
215185 |
0.07% |
股份
|
| Quadrature Capital Ltd |
$437825 |
210493 |
0.07% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$431400 |
207404 |
0.07% |
股份
|
| Headlands Technologies LLC |
$427342 |
205453 |
0.07% |
股份
|
| ROYAL BANK OF CANADA |
$388000 |
186427 |
0.06% |
股份
|
| OpenArc Corporate Advisory, LLC |
$362457 |
174258 |
0.06% |
股份
|
| CWM, LLC |
$359063 |
147157 |
0.06% |
股份
|
| Virtus Investment Advisers, LLC |
$358195 |
172209 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$354432 |
170400 |
0.05% |
买入期权
|
| PROFUND ADVISORS LLC |
$352972 |
169698 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$341280 |
161438 |
0.05% |
股份
|
| PARTNERS CAPITAL INVESTMENT GROUP, LLP |
$336122 |
161597 |
0.05% |
股份
|
| WINTON GROUP Ltd |
$328973 |
158160 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$324844 |
156175 |
0.05% |
股份
|
| Smartleaf Asset Management LLC |
$306080 |
137874 |
0.05% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$305000 |
146779 |
0.05% |
股份
|
| CHOREO, LLC |
$260129 |
125062 |
0.04% |
股份
|
| ALGERT GLOBAL LLC |
$254634 |
122420 |
0.04% |
股份
|
| Quantbot Technologies LP |
$243221 |
116933 |
0.04% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$240240 |
115500 |
0.04% |
股份
|
| Graham Capital Management, L.P. |
$237992 |
114419 |
0.04% |
股份
|
| Engineers Gate Manager LP |
$204903 |
98511 |
0.03% |
股份
|
| BANK OF NOVA SCOTIA |
$202592 |
97400 |
0.03% |
股份
|
| Xcelsior Advisor Partners LLC |
$199661 |
95991 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$194773 |
93641 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$173091 |
83217 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$171392 |
82400 |
0.03% |
卖出期权
|
| Mariner, LLC |
$167681 |
80616 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$164730 |
79197 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$162822 |
78280 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$149344 |
71800 |
0.02% |
买入期权
|
| Vanguard Personalized Indexing Management, LLC |
$141047 |
67811 |
0.02% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$137102 |
68551 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$132704 |
63800 |
0.02% |
卖出期权
|
| Rangeley Capital, LLC |
$127920 |
61500 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$127436 |
102771 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$122703 |
58992 |
0.02% |
股份
|
| CFG Wealth Management Services, Inc. |
$122000 |
40000 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$118059 |
56759 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$117562 |
56520 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$114256 |
54931 |
0.02% |
股份
|
| Schonfeld Strategic Advisors LLC |
$110403 |
53079 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$109782 |
52780 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$105872 |
50900 |
0.02% |
买入期权
|
| Navalign, LLC |
$102748 |
49398 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$100506 |
48320 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$100042 |
48097 |
0.02% |
股份
|
| E Fund Management Co., Ltd. |
$98993 |
47593 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$96273 |
46285 |
0.01% |
股份
|
| ProShare Advisors LLC |
$95825 |
46070 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$94519 |
45442 |
0.01% |
股份
|
| BOURGEON CAPITAL MANAGEMENT LLC |
$93600 |
45000 |
0.01% |
股份
|
| Arax Advisory Partners |
$91588 |
44033 |
0.01% |
股份
|
| Corient Private Wealth LP |
$85489 |
41100 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$81157 |
39018 |
0.01% |
股份
|
| Westmount Partners, LLC |
$74880 |
36000 |
0.01% |
股份
|
| Vontobel Holding Ltd. |
$72800 |
35000 |
0.01% |
股份
|
| State of Wyoming |
$70387 |
33840 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$68645 |
33002 |
0.01% |
股份
|
| XTX Topco Ltd |
$64320 |
30923 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$61404 |
29521 |
0.01% |
股份
|
| BBR PARTNERS, LLC |
$60220 |
28952 |
0.01% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$55816 |
26835 |
0.01% |
股份
|
| Abel Hall, LLC |
$54804 |
26348 |
0.01% |
股份
|
| Legal & General Group Plc |
$53545 |
25743 |
0.01% |
股份
|
| XPONANCE LLC |
$52649 |
25312 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$50155 |
24113 |
0.01% |
股份
|
| Polymer Capital Management (US) LLC |
$47439 |
22807 |
0.01% |
股份
|
| Coastal Bridge Advisors, LLC |
$45321 |
21789 |
0.01% |
股份
|
| Phoenix Wealth Advisors |
$43680 |
21000 |
0.01% |
股份
|
| R Squared Ltd |
$42118 |
20249 |
0.01% |
股份
|
| REGATTA CAPITAL GROUP, LLC |
$41600 |
20000 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$40144 |
19300 |
0.01% |
卖出期权
|
| GLENMEDE TRUST CO NA |
$39478 |
18980 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$38644 |
18579 |
0.01% |
股份
|
| M&T Bank Corp |
$38403 |
18463 |
0.01% |
股份
|
| HORIZON KINETICS ASSET MANAGEMENT LLC |
$34894 |
16776 |
0.01% |
股份
|
| INVESTMENT HOUSE LLC |
$34380 |
16529 |
0.01% |
股份
|
| Dynamic Technology Lab Private Ltd |
$33000 |
15866 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$32109 |
15437 |
0.00% |
股份
|
| GAMMA Investing LLC |
$31876 |
15325 |
0.00% |
股份
|
| &PARTNERS |
$31200 |
15000 |
0.00% |
股份
|
| Blueshift Asset Management, LLC |
$30994 |
14901 |
0.00% |
股份
|
| Callan Capital, LLC |
$30790 |
21089 |
0.00% |
股份
|
| CIBC Bancorp USA Inc. |
$30478 |
14653 |
0.00% |
股份
|
| SEVEN MILE ADVISORY |
$30023 |
14434 |
0.00% |
股份
|
| GTS SECURITIES LLC |
$27498 |
13220 |
0.00% |
股份
|
| KESTRA PRIVATE WEALTH SERVICES, LLC |
$26476 |
12729 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$25998 |
12499 |
0.00% |
股份
|
| Pallas Capital Advisors LLC |
$24636 |
11844 |
0.00% |
股份
|
| Focus Partners Wealth |
$24519 |
11788 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$24332 |
11698 |
0.00% |
股份
|
| OPPENHEIMER & CO INC |
$23920 |
11500 |
0.00% |
股份
|
| EP Wealth Advisors, LLC |
$23512 |
11304 |
0.00% |
股份
|
| Ballentine Partners, LLC |
$23152 |
11131 |
0.00% |
股份
|
| Advisors Capital Management, LLC |
$22884 |
11002 |
0.00% |
股份
|
| JSF Financial, LLC |
$22131 |
10640 |
0.00% |
股份
|
| Equitable Holdings, Inc. |
$20800 |
10000 |
0.00% |
股份
|
| Clear Harbor Asset Management, LLC |
$20800 |
10000 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$16721 |
8039 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$14679 |
7057 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$14186 |
6820 |
0.00% |
股份
|
| CIBC WORLD MARKETS CORP |
$13942 |
10177 |
0.00% |
股份
|
| Allworth Financial LP |
$11257 |
5412 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$11213 |
5391 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$11126 |
5349 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$9651 |
4639283 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$7758 |
3730 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$7707 |
6215 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$7602 |
3655 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$7532 |
3621579 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$5444 |
3729 |
0.00% |
股份
|
| Essential Partners LLC |
$4514 |
2170 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4399 |
2099 |
0.00% |
股份
|
| Raiffeisen Bank International AG |
$4160 |
2000 |
0.00% |
买入期权
|
| Parallel Advisors, LLC |
$2492 |
1198 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$2172 |
1044 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2138 |
1028 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$2080 |
1000 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1984 |
954 |
0.00% |
股份
|
| Twin Lakes Capital Management, LLC |
$1539 |
740 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$1354 |
654 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$1335 |
1077 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1233 |
593 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1115 |
536 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$1011 |
486 |
0.00% |
股份
|
| US BANCORP \DE\ |
$1011 |
486 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$955 |
459 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$944 |
454 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$936 |
450 |
0.00% |
股份
|
| True Wealth Design, LLC |
$785 |
377 |
0.00% |
股份
|
| Leonteq Securities AG |
$730 |
351 |
0.00% |
股份
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$686 |
330 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$660 |
318366 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$620 |
254 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$594 |
285590 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$439 |
211 |
0.00% |
股份
|
| PINNEY & SCOFIELD, INC. |
$399 |
192 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$331 |
159 |
0.00% |
股份
|
| NWI MANAGEMENT LP |
$208 |
100000 |
0.00% |
股份
|
| Virtu Financial LLC |
$203 |
97591 |
0.00% |
股份
|
| Cullen/Frost Bankers, Inc. |
$177 |
85 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$157 |
75949 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$145 |
69920 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$71 |
34 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$49 |
23151 |
0.00% |
股份
|
| ARCADIA INVESTMENT ADVISORS LLC |
$42 |
20 |
0.00% |
股份
|
| SHIKIAR ASSET MANAGEMENT INC |
$33 |
15750 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$12 |
5637 |
0.00% |
股份
|
| West Oak Capital, LLC |
$1 |
100 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
121 |
0.00% |
股份
|
| Avion Wealth |
$0 |
440 |
0.00% |
股份
|