ACET — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $8,057,871 | 932,624 | 14.03% | Shares |
| ORBIMED ADVISORS LLC | $7,298,960 | 844,787 | 12.71% | Shares |
| FRANKLIN RESOURCES INC | $5,413,573 | 626,571 | 9.43% | Shares |
| CITADEL ADVISORS LLC | $3,738,856 | 432,738 | 6.51% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $2,965,490 | 343,228 | 5.17% | Shares |
| VANGUARD GROUP INC | $2,452,552 | 291,277 | 4.27% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2,370,600 | 274,375 | 4.13% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $2,297,765 | 265,945 | 4.00% | Shares |
| Stonepine Capital Management, LLC | $2,121,276 | 245,518 | 3.69% | Shares |
| Aquilo Capital Management, LLC | $1,854,426 | 2,456,194 | 3.23% | Shares |
| Alyeska Investment Group, L.P. | $1,760,823 | 203,799 | 3.07% | Shares |
| Schonfeld Strategic Advisors LLC | $1,689,238 | 195,514 | 2.94% | Shares |
| Carlyle Group Inc. | $1,592,308 | 184,295 | 2.77% | Shares |
| NEXTBio Capital Management LP | $1,363,625 | 157,827 | 2.38% | Shares |
| TWO SIGMA ADVISERS, LP | $937,449 | 111,336 | 1.63% | Shares |
| TWO SIGMA INVESTMENTS, LP | $836,689 | 96,839 | 1.46% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $826,703 | 95,634 | 1.44% | Shares |
| DAFNA Capital Management LLC | $810,536 | 93,812 | 1.41% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $742,686 | 85,959 | 1.29% | Shares |
| MARSHALL WACE, LLP | $686,775 | 79,488 | 1.20% | Shares |
| Trexquant Investment LP | $673,937 | 78,002 | 1.17% | Shares |
| JANE STREET GROUP, LLC | $609,647 | 70,561 | 1.06% | Shares |
| Burkehill Global Management, LP | $540,000 | 62,500 | 0.94% | Shares |
| BlackRock, Inc. | $536,769 | 62,126 | 0.93% | Shares |
| REGENERON PHARMACEUTICALS, INC. | $522,819 | 60,511 | 0.91% | Shares |
| Rangeley Capital, LLC | $439,707 | 50,892 | 0.77% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $437,789 | 50,670 | 0.76% | Shares |
| RBF Capital, LLC | $333,348 | 38,582 | 0.58% | Shares |
| STATE STREET CORP | $312,958 | 36,222 | 0.55% | Shares |
| Quadrature Capital Ltd | $312,708 | 36,193 | 0.54% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $273,049 | 31,603 | 0.48% | Shares |
| UBS Group AG | $257,619 | 29,817 | 0.45% | Shares |
| Verdad Advisers, LP | $217,728 | 25,200 | 0.38% | Shares |
| XTX Topco Ltd | $209,814 | 24,284 | 0.37% | Shares |
| CITADEL ADVISORS LLC | $196,992 | 22,800 | 0.34% | Put option |
| JOHNSON & JOHNSON | $196,811 | 22,779 | 0.34% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $178,416 | 20,650 | 0.31% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $169,344 | 19,600 | 0.29% | Put option |
| PRELUDE CAPITAL MANAGEMENT, LLC | $160,272 | 18,550 | 0.28% | Shares |
| NORTHERN TRUST CORP | $159,287 | 18,436 | 0.28% | Shares |
| OCCUDO QUANTITATIVE STRATEGIES LP | $143,735 | 16,636 | 0.25% | Shares |
| Squarepoint Ops LLC | $131,795 | 15,254 | 0.23% | Shares |
| Vontobel Holding Ltd. | $119,025 | 13,776 | 0.21% | Shares |
| AXQ CAPITAL, LP | $94,962 | 10,991 | 0.17% | Shares |
| Jump Financial, LLC | $94,539 | 10,942 | 0.16% | Shares |
| CITADEL ADVISORS LLC | $92,534 | 10,710 | 0.16% | Call option |
| Arax Advisory Partners | $51,840 | 6,000 | 0.09% | Shares |
| Vanguard Global Advisers, LLC | $45,109 | 5,221 | 0.08% | Shares |
| SIMPLEX TRADING, LLC | $41,592 | 4,814 | 0.07% | Shares |
| MORGAN STANLEY | $19,795 | 2,291 | 0.03% | Shares |
| ROYAL BANK OF CANADA | $15,000 | 1,701 | 0.03% | Shares |
| Tower Research Capital LLC (TRC) | $2,393 | 277 | 0.00% | Shares |
| JPMORGAN CHASE & CO | $1,677 | 196 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $1,076 | 124,832 | 0.00% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $432 | 50 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $406 | 47 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $207 | 24 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $146 | 17 | 0.00% | Shares |
| FMR LLC | $52 | 6 | 0.00% | Shares |
| TD Waterhouse Canada Inc. | $26 | 3 | 0.00% | Shares |
| DANSKE BANK A/S | $9 | 1 | 0.00% | Shares |
| Avion Wealth | $2 | 246 | 0.00% | Shares |