DCTH Delcath Systems, Inc. - Common Stock

NASDAQ · Health Care · View on SEC EDGAR ↗
$17.21
Price · Aug 19, 2026
Fundamentals as of Aug 6, 2026

About Delcath Systems, Inc. - Common Stock Company overview from Wikipedia

Delcath Systems, Inc. is a publicly traded specialty pharmaceutical and medical device company, that develops percutaneous perfusion technologies for the targeted administration of high-dose chemotherapeutic agents to specific organs or regions of the body. Based in Queensbury, New York, the company has an intellectual property portfolio consisting of 28 patents worldwide. Delcath's Percutaneous Hepatic Perfusion (PHP) is currently undergoing Phase II and Phase III trials against tumors in the liver. Delcath has a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute and has received Fast Track and a Special Protocol Assessment from the Food and Drug Administration for its use of melphalan in treating unresectable liver tumors. PHP, also known as the Delcath System, is tested for the treatment of metastatic melanoma in the liver and for primary liver cancer and metastatic hepatic malignancies from neuroendocrine cancers and adenocarcinomas, as well as patients with melanoma who previously received isolated perfusion. Chemotherapy is usually delivered intravenously, although a number of agents can be administered orally.

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Delcath Systems, Inc. (NASDAQ: DCTH) is a publicly traded specialty pharmaceutical and medical device company, that develops percutaneous perfusion technologies for the targeted administration of high-dose chemotherapeutic agents to specific organs or regions of the body. Based in Queensbury, New York, the company has an intellectual property portfolio consisting of 28 patents worldwide. Delcath's Percutaneous Hepatic Perfusion (PHP) is currently undergoing Phase II and Phase III trials against tumors in the liver. Delcath has a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute and has received Fast Track and a Special Protocol Assessment from the Food and Drug Administration for its use of melphalan in treating unresectable liver tumors. PHP, also known as the Delcath System, is tested for the treatment of metastatic melanoma in the liver and for primary liver cancer and metastatic hepatic malignancies from neuroendocrine cancers and adenocarcinomas, as well as patients with melanoma who previously received isolated perfusion. Chemotherapy is usually delivered intravenously, although a number of agents can be administered orally (e.g. specialty drugs, melphalan (trade name Alkeran), busulfan, capecitabine).

## Phase III melanoma trial enrolling

University of Pittsburgh Medical Center

National Cancer Institute in Bethesda, Maryland

Albany Medical Center in Albany, New York

John Wayne Cancer Center in Santa Monica, California

Moffitt Cancer Center in Tampa, Florida

Morristown Memorial Hospital in Morristown, New Jersey

Providence Cancer Center in Portland, Oregon

St. Luke's Cancer Center of Bethlehem, Pennsylvania

Swedish Medical Center in Englewood, Colorado

University of Maryland Medical Center in Baltimore, Maryland

University of Texas Medical Branch in Galveston, Texas

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

DCTH Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$17.21
Market Cap
$597M
P/E (TTM)
245.9
EPS (TTM)
$0.07
Revenue (TTM)
$85M
Div Yield
ROE
2.5%
Debt/Equity
52W Range
$8 – $17

DCTH Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $85M
7-point trend, +4178.7%
2016-12-31 2025-12-31
EPS $0.07
9-point trend, +100.0%
2017-12-31 2025-12-31
Free Cash Flow $21M
8-point trend, +241.6%
2018-12-31 2025-12-31
Margins 3.2%
4-point trend, +15.2%
2022-12-31 2025-12-31

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
DCTH
Peer Median
P/E (TTM)
5-point trend, +6783.6%
245.9
32.9
P/S (TTM)
5-point trend, -76.2%
7.0
4.6
P/B
5-point trend, -38.6%
5.4
3.5
Price / FCF
5-point trend, +720.3%
28.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
DCTH
Peer Median
Gross Margin
4-point trend, +15.2%
86.2%
66.5%
Operating Margin
4-point trend, +100.1%
0.77%
Net Profit Margin
4-point trend, +100.2%
3.2%
-9.8%
ROA
5-point trend, +103.6%
2.7%
-8.8%
ROE
5-point trend, +101.2%
2.5%
-15.5%
ROIC
5-point trend, +100.2%
0.46%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
DCTH
Peer Median
Current Ratio
5-point trend, +108.6%
10.9
4.8
Quick Ratio
5-point trend, +31.4%
5.0

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
DCTH
Peer Median
Revenue YoY
5-point trend, +2297.5%
129.1%
Revenue CAGR 3Y
5-point trend, +2297.5%
215.3%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
DCTH
Peer Median
EPS (Diluted)
5-point trend, +101.9%
$0.07

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
DCTH
Peer Median

DCTH Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 12 analysts
  • Strong Buy 3 25.0%
  • Buy 8 66.7%
  • Hold 1 8.3%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-08-18
Median target $22.00 +27.8%
Mean target $24.00 +39.5%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.05%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.07 $-0.09 0.16%
March 31, 2026 $-0.03 $-0.09 0.06%
Dec. 31, 2025 $-0.05 $-0.06 0.01%
Sept. 30, 2025 $0.02 $0.02 -0.00%
June 30, 2025 $0.07 $0.03 0.04%
March 31, 2025 $0.03 $0.02 0.01%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
DCTH $350M 144.3 129.1% 3.2% 2.5% 86.2%
SIBN $861M -44.8 20.2% -9.4% -10.9% 79.6%
SSII -94.7 105.7%
ANGO $479M -13.0 9.5% -11.5% -21.2% 54.6%
TCMD $651M 35.4 12.5% 5.8% 9.2% 75.9%
NPCE $518M -23.4 25.1% -21.5% -111.6% 77.2%
CLPT $402M -15.2 17.8% -69.1% -106.9% 61.4%
SGHT $424M -10.7 -3.1% -49.7% -57.4% 86.2%
SENS $228M -3.3 56.9% -196.0% -88.7% 44.7%
ABT $250.18B 33.7 5.7% 14.7% 13.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 18
Annual Income Statement data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 9-point trend, +7873.0% $85M $37M $2M $3M $4M · · · $3M $2M $2M $1M
Cost of Revenue 12-point trend, +3954.0% $12M $6M $635.0K $686.0K $671.0K $640.0K $719.0K $1M $701.0K $550.0K $462.0K $291.0K
Gross Profit 12-point trend, +9338.8% $73M $31M $1M $2M $3M $1M $861.0K $2M $2M $1M $1M $778.0K
R&D Expense 12-point trend, +580.3% $29M $14M $18M $19M $14M $11M $9M $20M $10M $8M $6M $4M
SG&A Expense 12-point trend, +175.8% $44M $30M $22M $17M $14M $11M $11M $10M $10M $9M $10M $16M
Operating Expenses 12-point trend, +262.4% $73M $43M $40M $36M $27M $22M $21M $29M $20M $18M $16M $20M
Operating Income 12-point trend, +103.4% $660.0K $-12M $-38M $-34M $-25M $-21M $-20M $-27M $-18M $-16M $-15M $-19M
Interest Expense 3-point trend, +32292.5% · · · · · · · · $22M $14M $67.0K ·
Interest Income 3-point trend, +240.0% · · · · · · · · · $17.0K $9.0K $5.0K
Other Non-op 12-point trend, -191.7% $-70.0K $-30.0K $-59.0K $30.0K $68.0K $154.0K $2.0K $51.0K $-41.0K $17.0K $9.0K $-24.0K
Pretax Income 12-point trend, +120.2% $4M $-26M $-48M $-37M $-26M $-24M $-9M $-19M $-45M $-18M $-15M $-17M
Income Tax 12-point trend, +810000.00 $810.0K $0 $0 $0 $0 $0 $0 $0 $0 $0 $0 $0
Net Income 12-point trend, +115.5% $3M $-26M $-48M $-37M $-26M $-24M $-9M $-19M $-45M $-18M $-15M $-17M
EPS (Basic) 11-point trend, +104.3% $0.08 $-0.93 $-2.94 $-4.12 $-3.59 $-8.35 $-342.83 $-0.72 $-3250.00 · $-0.91 $-1.84
EPS (Diluted) 11-point trend, +103.8% $0.07 $-0.93 $-2.94 $-4.12 $-3.59 $-8.35 $-342.83 $-0.72 $-3250.00 · $-0.91 $-1.84
Shares (Basic) 11-point trend, +279.0% 35,821,157 28,511,393 16,229,931 8,864,615 7,145,754 2,897,827 25,900 26,705,375 14,039 · 16,161,687 9,452,050
Shares (Diluted) 11-point trend, +322.3% 39,919,557 28,511,393 16,229,931 8,864,615 7,145,754 2,897,827 25,900 26,705,375 14,039 · 16,161,687 9,452,050
EBITDA 10-point trend, +103.4% $660.0K $-12M $-38M $-34M $-25M $-21M $-20M $-27M · · $-15M $-19M
Balance Sheet 25
Annual Balance Sheet data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +112.3% $43M $32M $13M $8M $23M $29M $10M $3M $4M $4M $13M $20M
Receivables 12-point trend, +6649.4% $12M $11M $241.0K $366.0K $44.0K $57.0K $21.0K $585.0K $317.0K $403.0K $277.0K $174.0K
Inventory 12-point trend, +2837.5% $10M $7M $3M $2M $1M $855.0K $654.0K $858.0K $1M $660.0K $757.0K $349.0K
Prepaid Expense 12-point trend, +567.1% $6M $3M $1M $2M $3M $3M $2M $898.0K $700.0K $698.0K $960.0K $974.0K
Other Current Assets · · · · · · · · · · · $222.0K
Current Assets 12-point trend, +444.2% $120M $74M $37M $16M $31M $32M $13M $6M $8M $34M $15M $22M
PP&E (Net) 12-point trend, +76.1% $3M $2M $1M $1M $1M $1M $735.0K $925.0K $1M $1M $1M $2M
PP&E (Gross) 12-point trend, +51.7% $8M $7M $6M $6M $6M $6M $5M $5M $5M $5M $5M $6M
Accum. Depreciation 12-point trend, +40.0% $5M $5M $5M $5M $5M $5M $5M $4M $4M $4M $4M $4M
Total Assets 12-point trend, +420.2% $124M $77M $39M $18M $33M $35M $14M $7M $9M $35M $16M $24M
Accounts Payable 12-point trend, +255.3% $3M $961.0K $1M $2M $638.0K $2M $5M $8M $4M $594.0K $284.0K $748.0K
Accrued Liabilities 12-point trend, +127.3% $8M $5M $5M $5M $4M $5M $7M $8M $3M $3M $2M $4M
Current Liabilities 12-point trend, +139.3% $11M $6M $16M $15M $6M $10M $16M $18M $8M $36M $6M $5M
Capital Leases 7-point trend, +835000.00 $835.0K $933.0K $0 · $207.0K $450.0K $197.0K $0 · · · ·
Other Non-current Liabilities 11-point trend, -39.8% $628.0K $766.0K $840.0K $1M $207.0K · $0 $628.0K $395.0K $604.0K $820.0K $1M
Total Liabilities 12-point trend, +120.9% $12M $8M $23M $24M $21M $13M $21M $22M $8M $37M $7M $6M
Long-term Debt 3-point trend, -100.0% · $0 $10M $16M · · · · · · · ·
Common Stock 12-point trend, +257.7% $347.0K $331.0K $228.0K $100.0K $79.0K $60.0K $1.0K $0 $2.0K $0 $14.0K $97.0K
Paid-in Capital 12-point trend, +141.6% $639M $600M $521M $452M $433M $417M $365M $329M $326M $278M $270M $265M
Retained Earnings 12-point trend, -114.5% $-529M $-532M $-505M $-457M $-421M $-395M $-371M $-344M $-325M $-279M $-261M $-247M
Treasury Stock 5-point trend, -100.0% · · · · · · · $0 $51.0K $51.0K $51.0K $51.0K
AOCI 12-point trend, +2775.0% $575.0K $82.0K $135.0K $-83.0K $18.0K $-104.0K $28.0K $50.0K $42.0K $-41.0K $-8.0K $20.0K
Stockholders' Equity 12-point trend, +512.9% $111M $69M $16M $-6M $12M $22M $-6M $-15M $678.0K $-1M $9M $18M
Liabilities + Equity 12-point trend, +420.2% $124M $77M $39M $18M $33M $35M $14M $7M $9M $35M $16M $24M
Shares Outstanding 12-point trend, +257.3% 34,691,671 33,061,002 22,761,554 10,046,571 7,906,728 5,996,101 67,091 14,715 228,139 11,750 1,360,239 9,708,841
Cash Flow 12
Annual Cash Flow data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Deferred Tax Flat — no change across 2 periods $0 $0 · · · · · · · · · ·
Operating Cash Flow 12-point trend, +244.8% $23M $-19M $-31M $-25M $-23M $-23M $-24M $-15M $-15M $-14M $-16M $-16M
CapEx 12-point trend, +3415.9% $2M $559.0K $58.0K $209.0K $143.0K $782.0K $24.0K $76.0K $524.0K $258.0K $170.0K $44.0K
Investing Cash Flow 9-point trend, -4974.4% $-27M $-981.0K $-20M $-209.0K $-143.0K $-782.0K $-24.0K $-76.0K $-524.0K · · ·
Net Debt Issued 2-point trend, -67.9% · $-11M $-6M · · · · · · · · ·
Stock Issued 8-point trend, -95.6% $481.0K $250.0K $123.0K $0 $2M $230.0K $0 $11M · · · ·
Stock Repurchased 2-point trend, +6000000.00 $6M $0 · · · · · · · · · ·
Net Stock Activity 6-point trend, -5519000.00 $-6M $250.0K $123.0K · $2M $230.0K $0 · · · · ·
Financing Cash Flow 9-point trend, +243.1% $15M $39M $52M $10M $21M $42M $30M $13M $-11M · · ·
Net Change in Cash 12-point trend, +202.4% $11M $20M $874.0K $-15M $-2M $19M $7M $-2M $-26M $-8M $-8M $-11M
Taxes Paid 2-point trend, +1545000.00 $2M $0 · · · · · · · · · ·
Free Cash Flow 10-point trend, +234.5% $21M $-19M $-31M $-25M $-23M $-24M $-24M $-15M · · $-17M $-16M
Profitability 8
Annual Profitability data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Gross Margin 6-point trend, +18.4% 86.2% 83.4% 69.2% 74.8% · · · · · · 73.6% 72.8%
Operating Margin 6-point trend, +100.0% 0.77% -33.4% -1849.0% -1245.0% · · · · · · -870.6% -1805.8%
Net Margin 6-point trend, +100.2% 3.2% -70.9% -2308.9% -1342.7% · · · · · · -841.7% -1625.9%
Pretax Margin 5-point trend, +100.5% 4.1% -70.9% -2308.9% -1342.7% · · · · · · -841.7% ·
EBITDA Margin 6-point trend, +100.0% 0.77% -33.4% -1849.0% -1245.0% · · · · · · -870.6% -1805.8%
ROA 10-point trend, +104.7% 2.7% -45.8% -168.8% -143.2% -75.7% -98.9% -84.3% -244.4% · · -74.5% -57.1%
ROE 10-point trend, +103.5% 2.5% -68.2% -235.5% 657.5% -216.7% -190.6% 70.5% 194.1% · · -109.9% -72.0%
ROIC 8-point trend, +100.3% 0.46% -18.1% -242.0% 577.8% -205.3% -96.5% 313.2% · · · -176.8% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 10-point trend, +127.4% 10.9 12.0 2.3 1.1 5.2 3.2 0.8 0.3 · · 2.3 4.8
Quick Ratio 10-point trend, +11.7% 5.0 7.0 0.8 0.5 3.8 2.9 0.6 0.2 · · 2.0 4.5
Efficiency 3
Annual Efficiency data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 6-point trend, +2325.6% 0.9 0.6 0.1 0.1 · · · · · · 0.1 0.0
Inventory Turnover 10-point trend, +152.0% 1.4 1.2 0.2 0.4 0.6 0.8 1.0 1.0 · · 0.8 0.5
Receivables Turnover 6-point trend, +84.2% 7.5 6.7 6.8 13.3 · · · · · · 7.7 4.1
Per Share 5
Annual Per Share data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 10-point trend, +71.5% $3.21 $2.08 $0.69 $-0.74 $1.51 $3.68 $-94.75 $-1.46 · · $0.40 $1.87
Revenue / Share 6-point trend, +1787.8% $2.14 $1.30 $0.13 $0.31 · · · · · · $0.11 $0.11
Cash Flow / Share 8-point trend, +134.3% $0.56 $-0.66 $-1.93 $-2.81 · $-7.89 · $-0.55 · · $-1.02 $-1.65
Cash / Share 10-point trend, -40.6% $1.25 $0.98 $0.56 $0.97 $2.88 $4.77 $149.08 $0.25 · · $0.58 $2.11
EPS (TTM) 11-point trend, +103.8% $0.07 $-0.93 $-2.94 $-4.12 $-3.59 $-8.35 $-342.83 $-0.72 $-3250.00 · $-0.91 $-1.84
Growth Rates 2
Annual Growth Rates data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 4-point trend, +648.8% 129.1% 1701.7% -24.1% -23.5% · · · · · · · ·
Revenue CAGR 3Y 2-point trend, +81.3% 215.3% 118.7% · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for DCTH
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +7873.0% $85M $37M $2M $3M $4M $3M $3M $3M $3M $2M $2M $1M
Net Income TTM 12-point trend, +115.5% $3M $-26M $-48M $-37M $-26M $-24M $-9M $-19M $-45M $-18M $-15M $-17M
Market Cap 8-point trend, -82.5% $350M $398M $95M $28M $61M $107M $1M $2.01B · · · ·
P/E 8-point trend, +153.0% 144.3 -12.9 -1.4 -0.9 -2.2 -2.1 -0.1 -272.2 · · · ·
P/S 8-point trend, -99.4% 4.1 10.7 45.9 10.5 17.2 34.8 0.5 649.3 · · · ·
P/B 8-point trend, +102.3% 3.2 5.8 6.0 -4.9 5.1 4.9 -0.2 -134.2 · · · ·
P / Tangible Book 5-point trend, -35.3% 3.2 5.8 6.0 · 5.1 4.9 · · · · · ·
P / Cash Flow 8-point trend, +111.4% 15.6 -21.3 -3.0 -1.1 -2.7 -4.7 -0.1 -136.1 · · · ·
P / FCF 8-point trend, +112.3% 16.7 -20.7 -3.0 -1.1 -2.7 -4.5 -0.1 -135.4 · · · ·
Earnings Yield 8-point trend, +286.5% 0.69% -7.7% -70.7% -114.4% -46.3% -46.6% -1613.3% -0.37% · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $85M$37M$2M$3M$4M
Gross Margin % 86.2%83.4%69.2%74.8%
Operating Margin % 0.77%-33.4%-1849.0%-1245.0%
Net Income $3M$-26M$-48M$-37M$-26M
Diluted EPS $0.07$-0.93$-2.94$-4.12$-3.59
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 10.912.02.31.15.2
Quick Ratio 5.07.00.80.53.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $21M$-19M$-31M$-25M$-23M

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Institutional owners (13F) 140 filers · $188.2M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
27 (0 vs prior Q) 17 (-3 vs prior Q) 40 (+6 vs prior Q) 30 (-7 vs prior Q) +1.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Rosalind Advisors, Inc. $41,551,898 3,300,389 22.08% Shares
VANGUARD CAPITAL MANAGEMENT LLC $15,375,500 1,221,247 8.17% Shares
VANGUARD GROUP INC $14,879,573 1,473,225 7.91% Shares
Propel Bio Management, LLC $10,971,681 871,460 5.83% Shares
STATE STREET CORP $8,552,135 679,280 4.55% Shares
GEODE CAPITAL MANAGEMENT, LLC $7,923,535 629,139 4.21% Shares
ALGERT GLOBAL LLC $7,311,114 580,708 3.89% Shares
MILLENNIUM MANAGEMENT LLC $7,130,611 566,371 3.79% Shares
Divisadero Street Capital Management, LP $6,292,432 499,796 3.34% Shares
ExodusPoint Capital Management, LP $4,530,940 359,884 2.41% Shares
Private Wealth Advisors, LLC $3,913,765 310,863 2.08% Shares
Simplify Asset Management Inc. $3,333,454 264,770 1.77% Shares
BlackRock, Inc. $3,180,738 252,640 1.69% Shares
ADAR1 Capital Management, LLC $2,825,007 224,385 1.50% Shares
DIMENSIONAL FUND ADVISORS LP $2,570,450 204,166 1.37% Shares
KENNEDY CAPITAL MANAGEMENT LLC $2,570,160 204,143 1.37% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $2,435,510 193,448 1.29% Shares
Ikarian Capital, LLC $2,337,548 185,667 1.24% Shares
VANGUARD FIDUCIARY TRUST CO $2,290,159 181,903 1.22% Shares
CIBC WORLD MARKET INC. $2,054,789 163,208 1.09% Shares
Caption Management, LLC $1,894,795 150,500 1.01% Put option
GOLDMAN SACHS GROUP INC $1,885,353 149,750 1.00% Shares
Lane Generational LLC $1,884,257 149,663 1.00% Shares
HSBC HOLDINGS PLC $1,705,848 135,600 0.91% Shares
Man Group plc $1,617,752 128,495 0.86% Shares
Cubist Systematic Strategies, LLC $1,562,514 145,350 0.83% Shares
Diametric Capital, LP $1,546,568 122,841 0.82% Shares
MORGAN STANLEY $1,366,506 108,539 0.73% Shares
BARCLAYS PLC $1,354,243 107,565 0.72% Shares
Caption Management, LLC $1,259,000 100,000 0.67% Call option
Capital Advisors Wealth Management, LLC $1,170,870 93,000 0.62% Shares
Jefferies Financial Group Inc. $1,057,308 83,980 0.56% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,050,824 83,465 0.56% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,022,308 81,200 0.54% Call option
Stonepine Capital Management, LLC $1,000,000 100,000 0.53% Call option
Caption Management, LLC $978,243 77,700 0.52% Shares
FOX RUN MANAGEMENT, L.L.C. $776,526 61,678 0.41% Shares
Quantbot Technologies LP $749,860 59,560 0.40% Shares
D. E. Shaw & Co., Inc. $728,885 57,894 0.39% Shares
BNP PARIBAS FINANCIAL MARKETS $725,864 57,654 0.39% Shares
Pale Fire Capital SE $504,670 40,085 0.27% Shares
BANK OF AMERICA CORP /DE/ $493,931 39,232 0.26% Shares
WOLVERINE TRADING, LLC $479,600 44,000 0.25% Call option
RHUMBLINE ADVISERS $458,822 36,444 0.24% Shares
ALPS ADVISORS INC $441,154 35,040 0.23% Shares
EntryPoint Capital, LLC $437,641 34,761 0.23% Shares
SEI INVESTMENTS CO $394,936 31,369 0.21% Shares
AMERICAN CENTURY COMPANIES INC $378,380 30,054 0.20% Shares
Balyasny Asset Management L.P. $358,412 28,468 0.19% Shares
Leonteq Securities AG $348,730 27,699 0.19% Shares
CITADEL ADVISORS LLC $334,894 26,600 0.18% Call option
BOOTHBAY FUND MANAGEMENT, LLC $319,484 25,376 0.17% Shares
Xcelsior Advisor Partners LLC $318,527 25,300 0.17% Shares
Palisades Investment Partners, LLC $293,007 23,273 0.16% Shares
WOLVERINE TRADING, LLC $269,666 24,740 0.14% Shares
ALLIANCEBERNSTEIN L.P. $239,424 25,800 0.13% Shares
MetLife Investment Management, LLC $235,043 18,669 0.12% Shares
Bank of New York Mellon Corp $234,942 18,661 0.12% Shares
WealthPlan Investment Management, LLC $219,607 17,443 0.12% Shares
NOMURA HOLDINGS INC $210,530 16,722 0.11% Shares
WOLVERINE TRADING, LLC $209,280 19,200 0.11% Put option
CITADEL ADVISORS LLC $202,699 16,100 0.11% Put option
CITADEL ADVISORS LLC $189,391 15,043 0.10% Shares
SkyOak Wealth, LLC $188,850 15,000 0.10% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $188,850 15,000 0.10% Put option
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $166,729 13,243 0.09% Shares
TUDOR INVESTMENT CORP ET AL $151,609 12,042 0.08% Shares
LANARK FINANCIAL, INC. $150,500 11,954 0.08% Shares
CITIGROUP INC $146,485 11,635 0.08% Shares
Invesco Ltd. $143,790 11,421 0.08% Shares
MERCER GLOBAL ADVISORS INC /ADV $140,744 11,179 0.07% Shares
Nuveen, LLC $138,754 11,021 0.07% Shares
Vanguard Global Advisers, LLC $133,869 10,633 0.07% Shares
Schonfeld Strategic Advisors LLC $131,136 10,416 0.07% Shares
LPL Financial LLC $128,859 10,235 0.07% Shares
TWO SIGMA INVESTMENTS, LP $126,580 10,054 0.07% Shares
Police & Firemen's Retirement System of New Jersey $110,729 8,795 0.06% Shares
SHERBROOKE PARK ADVISERS LLC $109,918 10,883 0.06% Shares
Hunting Hill Global Capital, LLC $104,716 11,284 0.06% Shares
MARSHALL WACE, LLP $84,177 6,686 0.04% Shares
FMR LLC $69,144 5,492 0.04% Shares
Private Wealth Advisors, LLC $62,950 5,000 0.03% Call option
NEW YORK STATE COMMON RETIREMENT FUND $60,432 4,800 0.03% Shares
OSAIC HOLDINGS, INC. $60,254 4,786 0.03% Shares
Point72 (DIFC) Ltd $53,931 5,017 0.03% Shares
NORTHERN TRUST CORP $53,797 4,273 0.03% Shares
Persistent Asset Partners Ltd $52,954 4,206 0.03% Shares
Arax Advisory Partners $51,884 4,121 0.03% Shares
IFP Advisors, Inc $51,657 4,103 0.03% Shares
Integrated Wealth Concepts LLC $48,145 3,824 0.03% Shares
Ameritas Investment Partners, Inc. $38,714 3,075 0.02% Shares
Legal & General Group Plc $34,534 2,743 0.02% Shares
CWM, LLC $29,343 3,162 0.02% Shares
Creative Planning $17,777 1,412 0.01% Shares
Tripletail Wealth Management, LLC $16,632 1,260 0.01% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $14,950 1,611 0.01% Shares
AlphaQuest LLC $14,473 1,433 0.01% Shares
Tower Research Capital LLC (TRC) $13,711 1,089 0.01% Shares
Activest Wealth Management $12,590 1,000 0.01% Shares
Geneos Wealth Management Inc. $11,621 923 0.01% Shares

Company insiders 46 insiders · 11 officers · 16 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Jennifer K. Simpson President and CEO May 8, 2020 C 25,021 0 0 $0
Barbra Keck Chief Financial Officer, Secretary May 8, 2020 C 12,851 0 0 $0
Paul M Feinstein Chief Financial Officer Nov. 30, 2007 A 3,375 0 0 $0
John Purpura Chief Operating Officer Oct. 13, 2023 P 41,526 0 0 $0
HERSCHKOWITZ SAMUEL /FA/ Chief Operating Officer May 29, 2007 P 160,375 0 0 $0
Vojo Vukovic Chief Medical Officer Dec. 12, 2023 P 100,000 0 0 $0
Sandra Pennell SVP of Finance, PFO and PAO Nov. 17, 2023 P 30,000 0 0 $0
David L. Hoffman General Counsel, Chief Compliance Officer and Secretary Nov. 16, 2023 P 40,000 0 0 $0
Kevin Muir Vice President Commercial Operations June 12, 2023 A 0 0 $0
Johnny John Senior Vice President Clinical Development and Medical Affairs June 12, 2023 A 0 0 $0
Christine Padula Interim Principal Accounting Officer Sept. 1, 2021 A 0 0 $0
John Richard Sylvester Director Aug. 21, 2023 P 10,550 0 0 $0
Aharon Gil Director June 12, 2023 A 404,000 0 0 $0
Steven A J Salamon Director June 12, 2023 A 440,100 0 0 $0
Roger G Stoll PHD Director June 12, 2023 A 9,309 0 0 $0
Rosalind Advisors, Inc. Director April 19, 2022 P 433,100 0 0 $0
Marco Taglietti Director May 8, 2020 C 6,000 0 0 $0
William Dodge Rueckert Director May 8, 2020 C 6,014 0 0 $0
Simon Pedder Director Feb. 1, 2019 A 0 0 $0
Laura A Philips Director July 23, 2015 P 205,299 0 0 $0
Harold S Koplewicz Director June 10, 2015 A 45,052 0 0 $0
Dennis Langer Director June 10, 2015 A 20,000 0 0 $0
Jonathan Lewis Director June 30, 2008 A 10,000 0 0 $0
Mark Corigliano Director April 16, 2007 M 198,176 0 0 $0
Daniel Isdaner Director April 16, 2007 M 253,668 0 0 $0
Elizabeth Czerepak May 13, 2026 A 0 0 $0
Gerard J Michel March 2, 2026 P 342,034 2 0 $198,447
Laura Brege July 7, 2014 A 11,678 0 0 $0
Tasos Konidaris July 7, 2014 A 11,678 0 0 $0
Gabriel Leung July 7, 2014 A 21,485 0 0 $0
Douglas G Watson July 7, 2014 A 136,664 0 0 $0
Graham G Miao Nov. 14, 2013 A 54,000 0 0 $0
Peter J Graham Nov. 14, 2013 A 15,000 0 0 $0
William M Appling July 15, 2013 A 0 0 $0
Krishna Kandarpa March 11, 2013 A 159,000 0 0 $0
Harold Mapes March 11, 2013 A 17,000 0 0 $0
Eamonn P Hobbs March 11, 2013 A 162,000 0 0 $0
Agustin V Gago March 11, 2013 A 80,944 0 0 $0
Robert Ladd June 15, 2012 A 69,534 0 0 $0
David Mcdonald March 10, 2011 A 47,706 0 0 $0
Pamela Reilly Contag Dec. 1, 2010 A 8,507 0 0 $0
Richard Taney Dec. 10, 2009 A 211,485 0 0 $0
Jason Andrew Rifkin Oct. 12, 2009 A 0 0 $0
KOLY M S /FA/ Jan. 26, 2007 X 775,360 0 0 $0
Victor Nevins Oct. 12, 2006 M 180,007 0 0 $0
VENKOL TRUST Nov. 10, 2004 J 892,649 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 17 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Rosalind Advisors, Inc., SALAMON STEVEN A J, Aharon Gil, Rosalind Master Fund L.P., Rosalind Opportunities Fund I L.P. ×15 filings Feb. 10, 2026 9.90% Amendment SEC
Undisclosed reporting person Dec. 16, 2022 Initial filing Passive investment SEC
Undisclosed reporting person July 27, 2022 Initial filing Passive investment SEC
Laddcap Value Partners LP S.S. or, Laddcap Value Associates LLC S.S. or, Laddcap Value Advisors LLC S.S. or, Robert Ladd S.S. or ×2 filings Aug. 2, 2010 Initial filing SEC
Robert Ladd Oct. 18, 2006 Initial filing Passive investment SEC
Undisclosed reporting person July 28, 2006 Initial filing Board campaign SEC
Undisclosed reporting person July 11, 2006 Initial filing SEC
Undisclosed reporting person June 14, 2006 Initial filing SEC
Undisclosed reporting person June 8, 2006 Initial filing SEC
Undisclosed reporting person May 24, 2006 Initial filing SEC
Undisclosed reporting person April 28, 2006 Initial filing SEC
Undisclosed reporting person Jan. 10, 2006 Initial filing SEC
Undisclosed reporting person Jan. 6, 2006 Initial filing SEC
Undisclosed reporting person Dec. 14, 2005 Initial filing SEC
Undisclosed reporting person Nov. 10, 2005 Initial filing Board campaign SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 22 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
SBIO · ALPS ETF Trust 0.24% 35,814 NS May 31, 2026 N-PORT
IWC · iShares Trust 0.10% 97,850 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.04% 35,321 NS May 31, 2026 N-PORT
IWN · iShares Trust 0.02% 227,534 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 21,358 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.01% 741,852 SH Aug. 8, 2026 Daily
OMFS · Invesco Exchange-Traded Self-Indexe… 0.01% 2,388 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 165,177 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.01% 13,080 NS April 30, 2026 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.01% 22,609 NS May 31, 2026 N-PORT
ITWO · ProShares Trust 0.01% 1,420 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.00% 1,111 NS May 31, 2026 N-PORT
IWO · iShares Trust 0.00% 38,572 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.00% 1,122 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 1,638 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 28 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 19,222 NS April 30, 2026 N-PORT
ITOT · iShares Trust 0.00% 43,750 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.00% 304,809 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 889,410 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.00% 4,438 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 2,475 SH Aug. 8, 2026 Daily