ENTA Enanta Pharmaceuticals, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$13.41
Price · Aug 19, 2026
Fundamentals as of Aug 12, 2026

ENTA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$13.41
Market Cap
$287M
P/E (TTM)
-3.5
EPS (TTM)
$-3.84
Revenue (TTM)
$65M
Div Yield
ROE
-103.5%
Debt/Equity
52W Range
$7 – $17

ENTA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $65M
10-point trend, -26.0%
2016-09-30 2025-09-30
EPS $-3.84
10-point trend, -439.8%
2016-09-30 2025-09-30
Free Cash Flow $-32M
9-point trend, -164.1%
2017-09-30 2025-09-30
Margins -125.4%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ENTA
Peer Median
P/E (TTM)
5-point trend, +78.5%
-3.5
P/S (TTM)
5-point trend, -66.9%
4.4
10.1
P/B
5-point trend, +37.4%
4.4
4.8
Price / FCF
5-point trend, +51.0%
-8.9

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ENTA
Peer Median
Operating Margin
5-point trend, -15.7%
-130.7%
Net Profit Margin
5-point trend, -54.0%
-125.4%
-175.8%
ROA
5-point trend, -45.8%
-24.9%
-28.5%
ROE
5-point trend, -435.4%
-103.5%
-51.4%
ROIC
5-point trend, -541.8%
-129.3%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ENTA
Peer Median
Current Ratio
5-point trend, -52.3%
4.2
5.4
Quick Ratio
5-point trend, -63.9%
0.8

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ENTA
Peer Median
Revenue YoY
5-point trend, -32.7%
-3.4%
Revenue CAGR 3Y
5-point trend, -32.7%
-8.8%
Revenue CAGR 5Y
5-point trend, -32.7%
-11.8%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ENTA
Peer Median
EPS (Diluted)
5-point trend, +2.0%
$-3.84

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ENTA
Peer Median

ENTA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 12 analysts
  • Strong Buy 4 33.3%
  • Buy 7 58.3%
  • Hold 1 8.3%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

6 analysts · 2026-08-16
Median target $20.00 +49.1%
Mean target $21.17 +57.8%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.17%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.67 $-0.52 -0.15%
March 31, 2026 $-0.45 $-0.50 0.05%
Dec. 31, 2025 $-0.42 $-0.82 0.40%
Sept. 30, 2025 $-0.87 $-1.04 0.17%
June 30, 2025 $-0.85 $-1.30 0.45%
March 31, 2025 $-1.06 $-1.16 0.10%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ENTA $256M -3.1 -3.4% -125.4% -103.5%
PALI $375M -7.8 -25.4%
RCKT
XFOR $364M -2.1 150.0% -1218.5% -83.2%
GALT $271M -8.7 25.0%
DMAC $428M -78.7%
ZNTL $93M -0.7 -49.5%
IPSC $87M -7.1 1556.8% -8.8% -5.2%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +36.8% $65M $68M $79M $86M $97M $122M $205M $207M $103M $88M $161M $48M
R&D Expense 12-point trend, +469.6% $107M $131M $164M $165M $174M $137M $142M $95M $57M $40M $23M $19M
SG&A Expense 12-point trend, +338.6% $44M $58M $53M $45M $33M $27M $26M $23M $21M $17M $14M $10M
Operating Expenses 12-point trend, +424.0% $151M $189M $216M $210M $207M $164M $168M $118M $78M $57M $37M $29M
Operating Income 12-point trend, -549.6% $-85M $-122M $-137M $-124M $-110M $-42M $37M $88M $25M $31M $124M $19M
Interest Expense 7-point trend, +28500.0% · · $5M $0 $0 · · · $40.0K $45.0K $8.0K $18.0K
Interest Income 4-point trend, +442.2% · · · · · · · · $3M $2M $968.0K $467.0K
Other Non-op 10-point trend, +4.7% $2M $4M $6M $2M $2M $7M $9M $5M $2M $2M · ·
Pretax Income 12-point trend, -533.6% $-84M $-118M $-131M $-122M $-108M $-35M $46M $93M $27M $33M $125M $19M
Income Tax 12-point trend, +89.1% $-2M $-2M $3M $-433.0K $-29M $1M $-826.0K $21M $9M $11M $46M $-15M
Net Income 12-point trend, -337.8% $-82M $-116M $-134M $-122M $-79M $-36M $46M $72M $18M $22M $79M $34M
EPS (Basic) 12-point trend, -304.3% $-3.84 $-5.48 $-6.38 $-5.91 $-3.92 $-1.81 $2.37 $3.74 $0.93 $1.14 $4.23 $1.88
EPS (Diluted) 12-point trend, -313.3% $-3.84 $-5.48 $-6.38 $-5.91 $-3.92 $-1.81 $2.21 $3.48 $0.91 $1.13 $4.09 $1.80
Shares (Basic) 12-point trend, +16.2% 21,336 21,157 20,969 20,603 20,171 19,940 19,584,000 19,255,000 19,066,000 18,929,000 18,673,000 18,355
Shares (Diluted) 12-point trend, +11.2% 21,336 21,157 20,969 20,603 20,171 19,940 20,968,000 20,650,000 19,407,000 19,224,000 19,295,000 19,185
EBITDA 11-point trend, -549.6% $-85M $-122M $-137M $-124M $-110M $-42M $37M $88M $25M · $124M $19M
Balance Sheet 24
Annual Balance Sheet data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +5.2% $32M $37M $85M $44M $57M $87M $51M $64M $66M $17M $22M $31M
Short-term Investments 4-point trend, +163.0% · · · · · · · · $158M $194M $123M $60M
Receivables 12-point trend, +299.2% $7M $7M $9M $20M $24M $23M $51M $67M $11M $13M $15M $2M
Prepaid Expense 12-point trend, +438.9% $9M $12M $13M $13M $14M $14M $15M $4M $4M $9M $8M $2M
Current Assets 12-point trend, +89.2% $204M $300M $423M $312M $319M $437M $402M $380M $238M $232M $171M $108M
PP&E (Net) 12-point trend, +1863.1% $35M $33M $12M $6M $6M $9M $11M $8M $8M $8M $6M $2M
PP&E (Gross) 12-point trend, +897.0% $59M $58M $36M $28M $25M $24M $23M $17M $15M $13M $10M $6M
Accum. Depreciation 12-point trend, +475.7% $24M $25M $24M $22M $19M $16M $12M $9M $7M $5M $4M $4M
Other Non-current Assets 8-point trend, +0.0% $92.0K $94.0K $803.0K $696.0K $92.0K $92.0K $92.0K $92.0K · · · ·
Total Assets 12-point trend, +80.6% $281M $377M $462M $375M $439M $486M $490M $414M $327M $281M $246M $155M
Accounts Payable 12-point trend, +3.9% $2M $8M $4M $6M $10M $6M $7M $5M $4M $3M $2M $2M
Accrued Liabilities 12-point trend, +344.0% $13M $14M $18M $21M $22M $14M $16M $10M $8M $5M $4M $3M
Current Liabilities 12-point trend, +923.1% $49M $58M $63M $30M $36M $24M $23M $16M $21M $8M $7M $5M
Capital Leases 11-point trend, +10251.0% $55M $54M $21M $22M $1M $4M $200.0K $293.0K $379.0K $458.0K $529.0K ·
Other Non-current Liabilities 12-point trend, +13.5% $260.0K $231.0K $663.0K $454.0K $558.0K $1M $3M $3M $2M $2M $2M $229.0K
Total Liabilities 12-point trend, +3095.0% $216M $248M $246M $54M $39M $31M $27M $21M $25M $11M $10M $7M
Common Stock 12-point trend, +13.8% $214.0K $212.0K $211.0K $208.0K $202.0K $201.0K $197.0K $194.0K $191.0K $190.0K $187.0K $188.0K
Paid-in Capital · · · · · · · · · · · $222M
Retained Earnings 12-point trend, -454.6% $-405M $-323M $-207M $-73M $49M $128M $164M $117M $45M $28M $6M $-73M
Treasury Stock · · · · · · · · · · · $2.0K
AOCI 12-point trend, -239.0% $-339.0K $302.0K $-1M $-4M $-382.0K $844.0K $146.0K $-398.0K $-112.0K $19.0K $33.0K $-100.0K
Stockholders' Equity 12-point trend, -56.5% $65M $129M $217M $321M $399M $456M $462M $394M $302M $270M $236M $149M
Liabilities + Equity 12-point trend, +80.6% $281M $377M $462M $375M $439M $486M $490M $414M $327M $281M $246M $155M
Shares Outstanding 12-point trend, +15.0% 21,387,000 21,387,000 21,059,000 20,791,000 20,238,000 20,077,000 19,703,000 19,395,000 19,120,000 19,036,000 18,716,834 18,594,574
Cash Flow 11
Annual Cash Flow data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, +1202.8% $5M $2M $2M $3M $3M $4M $3M $3M $2M $2M $639.0K $352.0K
Stock-based Comp 12-point trend, +592.2% $19M $27M $28M $27M $21M $20M $19M $16M $13M $9M $6M $3M
Deferred Tax 2-point trend, -20.0% · · · · · $-18M · · · · · $-15M
Operating Cash Flow 12-point trend, -195.5% $-19M $-79M $-103M $-85M $-70M $7M $71M $29M $53M $36M $77M $20M
CapEx 12-point trend, +1154.5% $13M $18M $9M $2M $750.0K $1M $5M $3M $3M $5M $2M $1M
Investing Cash Flow 10-point trend, +192.4% $40M $58M $-54M $55M $37M $20M $-87M $-35M $-5M $-44M · ·
Financing Cash Flow 10-point trend, -1084.0% $-27M $-28M $198M $20M $3M $9M $3M $4M $1M $3M · ·
Net Change in Cash 12-point trend, -125.4% $-6M $-48M $41M $-10M $-30M $36M $-13M $-2M $49M $-5M $-9M $22M
Taxes Paid 3-point trend, +8424.3% · · · · · · · · · $13M $40M $148.0K
Free Cash Flow 11-point trend, -268.0% $-32M $-97M $-112M $-87M $-71M $6M $66M $26M $50M · $74M $19M
Levered FCF 4-point trend, -714.4% · · $-117M · · · · · $50M · $74M $19M
Profitability 7
Annual Profitability data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 11-point trend, -428.5% -130.7% -179.9% -173.2% -143.7% -112.9% -34.0% 17.9% 42.8% 23.9% · 77.2% 39.8%
Net Margin 11-point trend, -273.8% -125.4% -171.6% -168.9% -141.3% -81.4% -29.5% 22.6% 34.8% 17.2% · 49.1% 72.1%
Pretax Margin 11-point trend, -416.9% -127.9% -174.2% -165.4% -141.8% -110.8% -28.6% 22.2% 45.1% 26.2% · 78.0% 40.4%
EBITDA Margin 11-point trend, -428.5% -130.7% -179.9% -173.2% -143.7% -112.9% -34.0% 17.9% 42.8% 23.9% · 77.2% 39.8%
ROA 11-point trend, -198.5% -24.9% -27.7% -31.9% -29.9% -17.1% -7.4% 10.3% 19.4% 5.8% · 39.4% 25.3%
ROE 11-point trend, -489.4% -103.5% -83.6% -58.9% -36.9% -19.3% -7.7% 10.2% 19.1% 6.2% · 41.0% 26.6%
ROIC 11-point trend, -666.2% -129.3% -93.1% -64.7% -38.4% -20.1% -9.4% 8.1% 17.3% 5.4% · 33.1% 22.8%
Liquidity & Solvency 3
Annual Liquidity & Solvency data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -81.5% 4.2 5.2 6.7 10.5 8.8 18.1 17.8 23.7 11.3 · 25.5 22.8
Quick Ratio 11-point trend, -95.9% 0.8 0.8 1.5 2.2 2.2 4.6 4.5 8.2 11.2 · 23.9 19.5
Interest Coverage 4-point trend, -102.5% · · -26.7 · · · · · 615.4 · 15518.5 1054.7
Efficiency 2
Annual Efficiency data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 11-point trend, -43.3% 0.2 0.2 0.2 0.2 0.2 0.3 0.5 0.6 0.3 · 0.8 0.4
Receivables Turnover 11-point trend, -74.4% 9.7 8.9 5.5 3.9 4.1 3.3 3.5 5.3 8.8 · 18.9 37.7
Per Share 5
Annual Per Share data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, -62.1% $3.03 $6.08 $10.29 $15.46 $19.74 $22.69 $23.47 $20.30 $15.78 · $12.62 $7.99
Revenue / Share 11-point trend, +122938.1% $3061.68 $3196.81 $3777.19 $4181.92 $4.81 $6.14 $9.79 $10.01 $5.30 · $8.34 $2.49
Cash Flow / Share 11-point trend, -85977.7% $-903.26 $-3722.83 $-4919.36 $-4115.03 $-3.47 $0.36 $3.41 $1.42 $2.71 · $3.97 $1.05
Cash / Share 11-point trend, -8.5% $1.51 $1.76 $4.05 $2.12 $2.83 $4.34 $2.60 $3.29 $3.43 · $1.16 $1.65
EPS (TTM) 12-point trend, -313.3% $-3.84 $-5.48 $-6.38 $-5.91 $-3.92 $-1.81 $2.21 $3.48 $0.91 $1.13 $4.09 $1.80
Growth Rates 3
Annual Growth Rates data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +83.5% -3.4% -14.6% -8.1% -11.2% -20.7% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +34.8% -8.8% -11.3% -13.5% · · · · · · · · ·
Revenue CAGR 5Y -11.8% · · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for ENTA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +36.8% $65M $68M $79M $86M $97M $122M $205M $207M $103M $88M $161M $48M
Net Income TTM 12-point trend, -337.8% $-82M $-116M $-134M $-122M $-79M $-36M $46M $72M $18M $22M $79M $34M
Market Cap 11-point trend, -65.2% $256M $220M $235M $1.08B $1.15B $919M $1.18B $1.66B $895M · $676M $736M
P/E 12-point trend, -114.2% -3.1 -1.9 -1.8 -8.8 -14.5 -25.3 27.2 24.6 51.4 23.5 8.8 22.0
P/S 11-point trend, -74.6% 3.9 3.2 3.0 12.5 11.8 7.5 5.8 8.0 8.7 · 4.2 15.4
P/B 11-point trend, -20.1% 4.0 1.7 1.1 3.4 2.9 2.0 2.6 4.2 3.0 · 2.9 4.9
P / Tangible Book 6-point trend, +96.1% 4.0 1.7 1.1 3.4 2.9 2.0 · · · · · ·
P / Cash Flow 11-point trend, -136.4% -13.3 -2.8 -2.3 -12.7 -16.4 129.7 16.6 56.7 17.0 · 8.8 36.5
P / FCF 11-point trend, -120.7% -8.0 -2.3 -2.1 -12.4 -16.3 162.9 17.9 63.2 17.8 · 9.1 38.4
Earnings Yield 12-point trend, -805.1% -32.1% -52.9% -57.1% -11.4% -6.9% -4.0% 3.7% 4.1% 1.9% 4.2% 11.3% 4.5%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-09-302024-09-302023-09-302022-09-302021-09-30
Revenue $65M$68M$79M$86M$97M
Operating Margin % -130.7%-179.9%-173.2%-143.7%-112.9%
Net Income $-82M$-116M$-134M$-122M$-79M
Diluted EPS $-3.84$-5.48$-6.38$-5.91$-3.92
Balance Sheet
2025-09-302024-09-302023-09-302022-09-302021-09-30
Current Ratio 4.25.26.710.58.8
Quick Ratio 0.80.81.52.22.2
Cash Flow
2025-09-302024-09-302023-09-302022-09-302021-09-30
Free Cash Flow $-32M$-97M$-112M$-87M$-71M

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Institutional owners (13F) 136 filers · $263.4M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
20 (-4 vs prior Q) 19 (0 vs prior Q) 40 (-2 vs prior Q) 35 (+1 vs prior Q) +1.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
JANUS HENDERSON GROUP PLC $47,716,934 3,784,055 18.12% Shares
FARALLON CAPITAL MANAGEMENT, L.L.C. $35,257,385 2,418,202 13.39% Shares
Deep Track Capital, LP $21,055,955 1,444,167 7.99% Shares
ADAR1 Capital Management, LLC $19,602,956 1,344,510 7.44% Shares
VANGUARD CAPITAL MANAGEMENT LLC $17,667,592 1,211,769 6.71% Shares
Spruce Street Capital LP $15,873,698 1,088,731 6.03% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $14,747,583 1,011,494 5.60% Shares
GEODE CAPITAL MANAGEMENT, LLC $9,831,392 674,134 3.73% Shares
MILLENNIUM MANAGEMENT LLC $9,389,039 643,967 3.56% Shares
STATE STREET CORP $8,399,786 576,117 3.19% Shares
RENAISSANCE TECHNOLOGIES LLC $8,129,808 557,600 3.09% Shares
Hillsdale Investment Management Inc. $6,823,440 468,000 2.59% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $4,390,782 301,151 1.67% Shares
SummitTX Capital, L.P. $3,757,295 257,702 1.43% Shares
DIMENSIONAL FUND ADVISORS LP $3,728,033 255,695 1.42% Shares
GOLDMAN SACHS GROUP INC $2,984,599 204,705 1.13% Shares
VANGUARD FIDUCIARY TRUST CO $2,706,310 185,618 1.03% Shares
VANGUARD GROUP INC $2,593,329 164,447 0.98% Shares
TWO SIGMA ADVISERS, LP $2,259,841 143,300 0.86% Shares
Connor, Clark & Lunn Investment Management Ltd. $2,229,734 152,931 0.85% Shares
Opaleye Management Inc. $1,822,500 125,000 0.69% Shares
Qube Research & Technologies Ltd $1,181,053 81,005 0.45% Shares
XTX Topco Ltd $1,100,323 75,468 0.42% Shares
TWO SIGMA INVESTMENTS, LP $1,037,542 71,162 0.39% Shares
Campbell & CO Investment Adviser LLC $1,031,739 70,764 0.39% Shares
Trexquant Investment LP $1,014,958 69,613 0.39% Shares
MACKENZIE FINANCIAL CORP $982,211 67,367 0.37% Shares
Quantinno Capital Management LP $657,689 45,109 0.25% Shares
MORGAN STANLEY $654,525 44,892 0.25% Shares
CITADEL ADVISORS LLC $610,931 41,902 0.23% Shares
Cubist Systematic Strategies, LLC $598,297 49,983 0.23% Shares
STATE OF WISCONSIN INVESTMENT BOARD $596,439 40,908 0.23% Shares
PRUDENTIAL FINANCIAL INC $581,232 39,865 0.22% Shares
IEQ CAPITAL, LLC $561,447 38,508 0.21% Shares
PANAGORA ASSET MANAGEMENT INC $507,224 34,789 0.19% Shares
RHUMBLINE ADVISERS $504,034 34,571 0.19% Shares
D. E. Shaw & Co., Inc. $503,579 34,539 0.19% Shares
BANK OF MONTREAL /CAN/ $493,795 33,868 0.19% Shares
ALLIANCEBERNSTEIN L.P. $478,677 37,900 0.18% Shares
Bank of New York Mellon Corp $437,429 30,002 0.17% Shares
ALPS ADVISORS INC $430,227 29,508 0.16% Shares
FMR LLC $426,071 29,223 0.16% Shares
CITADEL ADVISORS LLC $381,996 26,200 0.15% Call option
WELLINGTON MANAGEMENT GROUP LLP $378,657 25,971 0.14% Shares
WELLS FARGO & COMPANY/MN $361,497 24,794 0.14% Shares
Portland Global Advisors LLC $353,929 24,275 0.13% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $351,553 24,112 0.13% Shares
MARTINGALE ASSET MANAGEMENT L P $346,684 23,778 0.13% Shares
BANK OF AMERICA CORP /DE/ $313,995 21,536 0.12% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $297,432 20,400 0.11% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $295,974 20,300 0.11% Put option
BlackRock, Inc. $286,147 19,626 0.11% Shares
CWM, LLC $277,115 21,941 0.11% Shares
BARCLAYS PLC $261,652 17,946 0.10% Shares
Headlands Technologies LLC $257,862 17,686 0.10% Shares
Susquehanna Portfolio Strategies, LLC $251,403 17,243 0.10% Shares
MetLife Investment Management, LLC $226,602 15,542 0.09% Shares
JPMORGAN CHASE & CO $225,993 15,575 0.09% Shares
AlphaQuest LLC $223,587 14,178 0.08% Shares
Balyasny Asset Management L.P. $217,461 14,915 0.08% Shares
Engineers Gate Manager LP $190,706 13,080 0.07% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $190,517 13,067 0.07% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $185,166 12,700 0.07% Call option
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $182,416 13,315 0.07% Shares
CITIGROUP INC $178,459 12,240 0.07% Shares
Russell Investments Group, Ltd. $174,799 11,989 0.07% Shares
Invesco Ltd. $162,815 11,167 0.06% Shares
Vanguard Global Advisers, LLC $153,804 10,549 0.06% Shares
Police & Firemen's Retirement System of New Jersey $144,954 9,942 0.06% Shares
Arax Advisory Partners $104,699 7,181 0.04% Shares
NEW YORK STATE COMMON RETIREMENT FUND $88,515 6,071 0.03% Shares
MERCER GLOBAL ADVISORS INC /ADV $87,859 6,026 0.03% Shares
Clearstead Trust, LLC $73,834 5,064 0.03% Shares
China Universal Asset Management Co., Ltd. $67,476 4,628 0.03% Shares
NORTHERN TRUST CORP $64,896 4,451 0.02% Shares
BNP PARIBAS FINANCIAL MARKETS $62,373 4,278 0.02% Shares
STRS OHIO $46,656 3,200 0.02% Shares
Krensavage Asset Management, LLC $41,788 2,866,138 0.02% Shares
Legal & General Group Plc $40,970 2,810 0.02% Shares
MARSHALL WACE, LLP $39,453 2,706 0.01% Shares
Ameritas Investment Partners, Inc. $37,544 2,575 0.01% Shares
Pinnacle Wealth Planning Services, Inc. $36,873 2,529 0.01% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $27,017 1,853 0.01% Shares
AQR CAPITAL MANAGEMENT LLC $26,988 1,851 0.01% Shares
Nuveen, LLC $23,649 1,622 0.01% Shares
Tower Research Capital LLC (TRC) $23,430 1,607 0.01% Shares
Versant Capital Management, Inc $20,762 1,424 0.01% Shares
GAMMA Investing LLC $19,756 1,355 0.01% Shares
Mirae Asset Global Investments Co., Ltd. $18,954 1,300 0.01% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $18,642 1,476 0.01% Shares
ACADIAN ASSET MANAGEMENT LLC $15,706 1,078,317 0.01% Shares
ROYAL BANK OF CANADA $12,000 850 0.00% Shares
True Wealth Design, LLC $9,405 645 0.00% Shares
GF FUND MANAGEMENT CO. LTD. $8,996 617 0.00% Shares
Point72 (DIFC) Ltd $8,846 739 0.00% Shares
State of Wyoming $7,727 530 0.00% Shares
Rockefeller Capital Management L.P. $7,494 514 0.00% Shares
FRANKLIN RESOURCES INC $7,057 484 0.00% Shares
Allworth Financial LP $5,876 403 0.00% Shares
IFP Advisors, Inc $5,861 402 0.00% Shares

Company insiders 24 insiders · 9 officers · 14 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Jay R. Luly, Ph.D. President and CEO Feb. 12, 2025 F 864,654 0 0 $0
Brendan Luu Chief Business Officer Feb. 12, 2025 F 40,221 0 0 $0
Tara Lynn Kieffer Chief Product Strategy Officer Feb. 12, 2025 F 33,479 0 0 $0
Yat Sun Or Chief Scientific Officer Feb. 12, 2025 F 374,535 0 0 $0
Paul J Mellett Chief Fin. & Admin Officer Feb. 12, 2025 F 95,884 0 0 $0
Matthew Paul Kowalsky Chief Legal Officer Nov. 27, 2024 A 0 0 $0
Nathaniel S. Gardiner Chief Legal Officer Feb. 26, 2024 M 75,688 0 0 $0
Nathalie Adda Sr. VP & Chief Medical Officer April 4, 2022 M 34,982 0 0 $0
Tim Ocain Senior Vice President Feb. 12, 2019 F 17,547 0 0 $0
Yujiro S Hata Director March 13, 2025 A 0 0 $0
Terry Vance Director March 13, 2025 A 5,800 0 0 $0
Kristine Peterson Director March 13, 2025 A 0 0 $0
Lesley Russell Director March 13, 2025 A 0 0 $0
Mark G Foletta Director March 13, 2025 A 0 0 $0
Bruce L A Carter Director March 13, 2025 A 0 0 0 $0
George Golumbeski Director Feb. 26, 2020 A 0 0 0 $0
Stephen Buckley Jr. Director Feb. 28, 2019 A 2,000 0 0 $0
AFTING ERNST-GUENTER Director Feb. 11, 2016 A 17,287 0 0 $0
Helmut Schuhsler Director Feb. 24, 2014 S 1,572,670 0 0 $0
Marc E. Goldberg Director Dec. 6, 2013 S 547,606 0 0 $0
Gregory L. Verdine Director March 26, 2013 P 3,324 0 0 $0
David Poorvin Director March 20, 2013 A 0 0 $0
SHIONOGI & CO LTD 10% owner March 26, 2013 C 1,599,760 0 0 $0
Scott T. Rottinghaus Aug. 8, 2026 F 23,787 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Jay R. Luly, Ph.D. ×4 filings Feb. 14, 2025 7.70% Amendment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 32 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
QQQS · Invesco Exchange-Traded Fund Trust … 0.52% 8,498 SH Aug. 8, 2026 Daily
IWC · iShares Trust 0.09% 96,445 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.06% 80,033 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.03% 201,229 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.03% 1,570 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.02% 1,072 NS May 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 34,951 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.01% 136,061 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.01% 720,999 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.01% 12,002 NS April 30, 2026 N-PORT
IWO · iShares Trust 0.01% 126,416 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 163,048 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.01% 12,720 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.01% 14,867 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.01% 1,284 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 128,383 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.01% 1,004 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.00% 1,017 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 34,139 NS April 30, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 1,314 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 25 NS May 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.00% 2,200 NS April 30, 2026 N-PORT
AVSU · AMERICAN CENTURY ETF TRUST 0.00% 296 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 47,708 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 4,909 SH Aug. 8, 2026 Daily
DFAU · Dimensional ETF Trust 0.00% 2,629 NS April 30, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 10,879 NS May 31, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 3,542 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 308,121 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 877,120 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 2,291 SH Aug. 8, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 1,234 NS April 30, 2026 N-PORT