XFOR X4 Pharmaceuticals, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$4.28
Price · Aug 18, 2026
Fundamentals as of Aug 6, 2026

XFOR Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$4.28
Market Cap
$389M
P/E (TTM)
-2.3
EPS (TTM)
$-1.87
Revenue (TTM)
$6M
Div Yield
ROE
-83.2%
Debt/Equity
52W Range
$2 – $5

XFOR Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $6M
8-point trend, +6500000.00
2018-12-31 2025-12-31
EPS $-1.87
6-point trend, +39.5%
2020-12-31 2025-12-31
Free Cash Flow $-86M
8-point trend, -109.1%
2018-12-31 2025-12-31
Margins -1218.5%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
XFOR
Peer Median
P/E (TTM)
5-point trend, +87.6%
-2.3
P/S (TTM)
3-point trend, -94.7%
59.9
289.4
P/B
5-point trend, -93.5%
2.1
2.7
Price / FCF
5-point trend, +84.3%
-4.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
XFOR
Peer Median
Operating Margin
4-point trend, -2.0%
-1336.7%
Net Profit Margin
4-point trend, +0.9%
-1218.5%
-1021.1%
ROA
5-point trend, +50.9%
-36.2%
-57.7%
ROE
5-point trend, +37.5%
-83.2%
-69.1%
ROIC
5-point trend, +46.1%
-46.7%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
XFOR
Peer Median
Current Ratio
5-point trend, +62.1%
10.2
8.2
Quick Ratio
5-point trend, +44.9%
8.4

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
XFOR
Peer Median
Revenue YoY
5-point trend, +6500000.00
150.0%
Revenue CAGR 5Y
5-point trend, +6500000.00
16.7%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
XFOR
Peer Median
EPS (Diluted)
5-point trend, +53.1%
$-1.87

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
XFOR
Peer Median

XFOR Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 11 analysts
  • Strong Buy 5 45.5%
  • Buy 5 45.5%
  • Hold 1 9.1%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-08-18
Median target $12.00 +180.4%
Mean target $11.60 +171.0%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.77%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.13 $-0.18 0.05%
March 31, 2026 $-0.16 $-0.20 0.04%
Dec. 31, 2025 $-0.22 $-0.35 0.13%
Sept. 30, 2025 $-0.69 $-0.93 0.24%
June 30, 2025 $-3.47 $-4.42 0.95%
March 31, 2025 $0.04 $-4.53 4.6%
Dec. 31, 2024 $-6.00 $-5.36 -0.65%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
XFOR $364M -2.1 150.0% -1218.5% -83.2%
LXEO $725M -5.3 -51.9%
FHTX $306M -4.6 36.8% -240.3% 80.2%
UPB $1.47B -10.2 20.4% -5026.0% -38.3%
PALI $375M -7.8 -25.4%
RCKT

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for XFOR
Metric Trend 20252024202320222021202020192018
Revenue 8-point trend, +6500000.00 $6M $3M $0 $0 $0 $3M $0 $0
Cost of Revenue 4-point trend, +5757000.00 $6M $797.0K $0 $0 · · · ·
R&D Expense 8-point trend, +257.4% $73M $82M $72M $61M $51M $42M $30M $20M
SG&A Expense 8-point trend, +398.0% $44M $62M $36M $27M $25M $21M $18M $9M
Operating Expenses 7-point trend, +33.9% · $39M $108M $88M $85M $63M $52M $29M
Operating Income 8-point trend, -198.7% $-87M $-36M $-108M $-88M $-85M $-60M $-52M $-29M
Interest Expense 6-point trend, +702.4% · · $6M $4M $4M $3M $2M $720.0K
Interest Income 8-point trend, +1839.0% $5M $6M $5M $219.0K $10.0K $273.0K $1M $236.0K
Other Non-op 8-point trend, -753000.00 $-753.0K $332.0K $554.0K $-4M $426.0K $905.0K $517.0K $0
Pretax Income 8-point trend, -137.8% $-79M $-37M $-101M $-94M $-89M $-62M $-53M $-33M
Income Tax 8-point trend, +41000.00 $41.0K $310.0K $78.0K $28.0K $17.0K $148.0K $0 $0
Net Income 8-point trend, -137.9% $-79M $-37M $-101M $-94M $-89M $-62M $-53M $-33M
EPS (Basic) 6-point trend, +39.5% $-1.87 $-5.59 $-17.07 $-1.52 $-3.99 $-3.09 · ·
EPS (Diluted) 6-point trend, +39.5% $-1.87 $-5.59 $-17.07 $-1.52 $-3.99 $-3.09 · ·
Shares (Basic) 6-point trend, +110.7% 42,292,818 6,702,073 5,927,082 63,525,845 25,748,797 20,077,000 · ·
Shares (Diluted) 6-point trend, +110.7% 42,292,818 6,702,073 5,927,082 63,525,845 25,748,797 20,077,000 · ·
EBITDA 8-point trend, -87.2% $-86M $-36M $-107M $-87M $-85M $-60M $-52M $-46M
Balance Sheet 26
Annual Balance Sheet data for XFOR
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, +2568.4% $217M $56M $99M $122M $82M $79M $126M $8M
Receivables 4-point trend, +573000.00 $573.0K $1M $0 · · · $0 ·
Inventory 2-point trend, +2817000.00 · $3M $0 · · · · ·
Prepaid Expense 8-point trend, +192.7% $4M $6M $7M $6M $5M $4M $1M $1M
Current Assets 8-point trend, +2700.9% $262M $112M $122M $129M $88M $83M $129M $9M
PP&E (Net) 8-point trend, -24.5% $182.0K $776.0K $745.0K $1M $2M $1M $403.0K $241.0K
PP&E (Gross) 8-point trend, +239.1% $1M $3M $2M $2M $2M $2M $667.0K $417.0K
Accum. Depreciation 8-point trend, +600.0% $1M $2M $2M $1M $724.0K $274.0K $264.0K $176.0K
Goodwill 8-point trend, +17351000.00 $17M $17M $17M $17M $17M $27M $27M $0
Intangibles 3-point trend, +9250000.00 $9M $10M $0 · · · · ·
Other Non-current Assets 8-point trend, +90.1% $692.0K $2M $1M $1M $2M $3M $2M $364.0K
Total Assets 8-point trend, +2821.0% $290M $146M $147M $156M $117M $123M $161M $10M
Accounts Payable 8-point trend, +91.8% $6M $9M $9M $8M $4M $3M $2M $3M
Accrued Liabilities 8-point trend, +472.2% $19M $23M $13M $12M $8M $8M $6M $3M
Current Liabilities 8-point trend, +225.7% $26M $33M $23M $22M $14M $12M $9M $8M
Capital Leases 7-point trend, -100.0% $0 $1M $3M $4M $5M $4M $2M ·
Other Non-current Liabilities 8-point trend, +156.1% $525.0K $831.0K $432.0K $173.0K $826.0K $462.0K $16.0K $205.0K
Total Liabilities 8-point trend, +381.8% $104M $124M $96M $82M $53M $50M $31M $22M
Long-term Debt 8-point trend, +650.0% $75M $75M $55M $32M $32M $32M $20M $10M
Total Debt 4-point trend, +172.8% · · $55M $34M $34M · $20M ·
Common Stock 8-point trend, +91000.00 $91.0K $6.0K $167.0K $122.0K $28.0K $16.0K $16.0K $0
Retained Earnings 8-point trend, -650.3% $-595M $-515M $-478M $-377M $-283M $-194M $-132M $-79M
AOCI 8-point trend, -109000.00 $-109.0K $-122.0K $-119.0K $-119.0K $-119.0K $-119.0K $-119.0K $0
Stockholders' Equity 8-point trend, +341.7% $186M $22M $51M $74M $64M $73M $129M $-77M
Liabilities + Equity 8-point trend, +2821.0% $290M $146M $147M $156M $117M $123M $161M $10M
Shares Outstanding 8-point trend, +25751.4% 90,906,920 5,698,231 167,434,595 121,667,250 28,127,657 16,305,731 16,128,862 351,652
Cash Flow 17
Annual Cash Flow data for XFOR
Metric Trend 20252024202320222021202020192018
D&A 8-point trend, +1139.8% $1M $796.0K $419.0K $513.0K $499.0K $351.0K $103.0K $103.0K
Stock-based Comp 8-point trend, +466.3% $4M $8M $9M $5M $6M $5M $2M $759.0K
Amort. of Intangibles 3-point trend, +500000.00 · $500.0K $0 $0 · · · ·
Restructuring 3-point trend, +251.2% $7M $861.0K · · · · · $2M
Other Non-cash 8-point trend, -228.0% $-12M $-102M $-4M $11M $11M $-2M $3M $-4M
Operating Cash Flow 8-point trend, -236.8% $-86M $-131M $-97M $-77M $-71M $-59M $-48M $-25M
CapEx 8-point trend, +0.00 $0 $326.0K $60.0K $103.0K $615.0K $1M $174.0K $0
Investing Cash Flow 8-point trend, +8154000.00 $8M $67M $-15M $-103.0K $-615.0K $-1M $27M $0
Net Debt Issued 8-point trend, +100.0% $0 $0 $-2M $-795.0K $0 $0 $-9M $-5M
Stock Issued 3-point trend, +297.6% $239M $0 $60M · · · · ·
Stock Repurchased 5-point trend, +0.00 · · $0 $0 $2M $0 $0 ·
Net Stock Activity 4-point trend, +12026.5% $239M · $0 $0 $-2M · · ·
Financing Cash Flow 8-point trend, +3373.5% $239M $20M $89M $117M $74M $12M $141M $7M
Net Change in Cash 8-point trend, +970.0% $161M $-44M $-23M $40M $2M $-47M $120M $-19M
Taxes Paid $338.0K · · · · · · ·
Free Cash Flow 8-point trend, -109.1% $-86M $-131M $-97M $-77M $-72M $-60M $-48M $-41M
Levered FCF 4-point trend, -62.8% · · $-102M $-81M $-75M $-63M · ·
Profitability 7
Annual Profitability data for XFOR
Metric Trend 20252024202320222021202020192018
Operating Margin 4-point trend, -2.0% -1336.7% -1423.6% · · · -1995.8% · -1311.0%
Net Margin 4-point trend, +0.9% -1218.5% -1464.6% · · · -2071.0% · -1229.2%
Pretax Margin 4-point trend, +0.9% -1217.8% -1452.5% · · · -2066.1% · -1229.2%
EBITDA Margin 4-point trend, -0.8% -1317.0% -1392.5% · · · -1984.1% · -1306.6%
ROA 8-point trend, +50.6% -36.2% -25.5% -66.8% -68.8% -73.9% -43.8% -61.9% -73.4%
ROE 8-point trend, -143.0% -83.2% -91.6% -170.5% -138.1% -133.3% -76.5% -50.7% 193.4%
ROIC 6-point trend, +43.4% -46.7% -165.7% -101.8% -81.4% -86.6% -82.4% · ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for XFOR
Metric Trend 20252024202320222021202020192018
Current Ratio 8-point trend, +56.3% 10.2 3.4 5.3 5.8 6.3 7.0 13.7 6.5
Quick Ratio 8-point trend, +48.3% 8.4 1.7 4.3 5.5 5.8 6.6 13.4 5.7
Debt / Equity 4-point trend, +589.9% · · 1.1 0.5 0.5 · 0.2 ·
LT Debt / Equity 4-point trend, +589.9% · · 1.1 0.4 0.5 · 0.2 ·
Interest Coverage 6-point trend, +57.9% · · -18.6 -21.9 -23.4 -22.3 -24.1 -44.2
Efficiency 3
Annual Efficiency data for XFOR
Metric Trend 20252024202320222021202020192018
Asset Turnover 6-point trend, -50.1% 0.0 0.0 · 0.0 0.0 0.0 · 0.1
Inventory Turnover · 0.6 · · · · · ·
Receivables Turnover 2-point trend, +65.6% 7.9 4.8 · · · · · ·
Per Share 5
Annual Per Share data for XFOR
Metric Trend 20252024202320222021202020192018
Book Value / Share 8-point trend, +38.2% $2.05 $0.13 $0.31 $0.61 $2.29 $4.46 $8.01 $1.48
Revenue / Share 3-point trend, +0.15 $0.15 $0.01 · $0.00 · · · ·
Cash Flow / Share 4-point trend, -66.8% $-2.02 $-0.65 $-0.54 $-1.21 · · · ·
Cash / Share 8-point trend, +13.1% $2.39 $0.33 $0.59 $1.00 $2.91 $4.83 $7.82 $2.11
EPS (TTM) 6-point trend, +39.5% $-1.87 $-5.59 $-17.07 $-1.52 $-3.99 $-3.09 · ·
Growth Rates 2
Annual Growth Rates data for XFOR
Metric Trend 20252024202320222021202020192018
Revenue YoY 150.0% · · · · · · ·
Revenue CAGR 5Y 16.7% · · · · · · ·
Valuation (TTM) 13
Annual Valuation (TTM) data for XFOR
Metric Trend 20252024202320222021202020192018
Revenue TTM 8-point trend, +6500000.00 $6M $3M $0 $0 $0 $3M $0 $0
Net Income TTM 8-point trend, -137.9% $-79M $-37M $-101M $-94M $-89M $-62M $-53M $-33M
Market Cap 8-point trend, -94.0% $364M $3.76B $4.21B $3.62B $1.93B $3.15B $5.18B $6.09B
Enterprise Value 4-point trend, -17.8% · · $4.17B $3.54B $1.88B · $5.07B ·
P/E 6-point trend, +96.6% -2.1 -3.9 -1.5 -19.6 -17.2 -62.4 · ·
P/S 3-point trend, -94.7% 55.9 1447.8 · · · 1048.5 · ·
P/B 8-point trend, -99.3% 2.0 170.0 82.5 48.9 30.0 43.2 40.1 281.7
P / Tangible Book 5-point trend, -96.7% 2.3 · 124.9 63.9 41.1 68.8 · ·
P / Cash Flow 8-point trend, +97.1% -4.2 -28.8 -43.7 -47.0 -27.3 -53.5 -107.7 -148.8
P / FCF 8-point trend, +97.1% -4.2 -28.7 -43.6 -46.9 -27.0 -52.3 -107.3 -148.7
EV / EBITDA 4-point trend, +60.4% · · -38.9 -40.6 -22.3 · -98.3 ·
EV / FCF 4-point trend, +58.9% · · -43.2 -45.8 -26.3 · -105.1 ·
Earnings Yield 6-point trend, -2821.9% -46.8% -25.4% -67.8% -5.1% -5.8% -1.6% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $6M$3M$0$0$0
Operating Margin % -1336.7%-1423.6%
Net Income $-79M$-37M$-101M$-94M$-89M
Diluted EPS $-1.87$-5.59$-17.07$-1.52$-3.99
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 1.10.50.5
Current Ratio 10.23.45.35.86.3
Quick Ratio 8.41.74.35.55.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-86M$-131M$-97M$-77M$-72M

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Institutional owners (13F) 92 filers · $429.4M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
38 (+24 vs prior Q) 25 (+16 vs prior Q) 19 (-2 vs prior Q) 13 (-7 vs prior Q) +7.8M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
MORGAN STANLEY $44,014,736 9,424,997 10.25% Shares
FMR LLC $38,862,138 8,321,657 9.05% Shares
Bain Capital Life Sciences Investors, LLC $37,208,011 7,967,454 8.66% Shares
PERCEPTIVE ADVISORS LLC $37,049,403 7,933,491 8.63% Shares
Saturn V Capital Management LP $32,565,512 6,973,343 7.58% Shares
Empery Asset Management, LP $32,365,860 6,930,591 7.54% Shares
Deep Track Capital, LP $27,453,795 5,878,757 6.39% Shares
Kalehua Capital Management LLC $17,385,663 3,722,840 4.05% Shares
VANGUARD CAPITAL MANAGEMENT LLC $17,353,062 3,715,859 4.04% Shares
Rosalind Advisors, Inc. $15,012,957 3,214,766 3.50% Shares
BRAIDWELL LP $13,649,261 2,922,754 3.18% Shares
Blackstone Inc. $12,524,576 2,681,922 2.92% Shares
Trails Edge Capital Partners, LP $12,008,803 2,571,478 2.80% Shares
VANGUARD GROUP INC $11,639,808 2,909,952 2.71% Shares
Nantahala Capital Management, LLC $11,439,016 2,449,468 2.66% Shares
BVF INC/IL $10,431,575 2,233,742 2.43% Shares
Venrock Adviser, LLC $9,032,962 1,934,253 2.10% Shares
GEODE CAPITAL MANAGEMENT, LLC $8,383,316 1,794,568 1.95% Shares
SAMSARA BIOCAPITAL, LLC $6,517,391 1,395,587 1.52% Shares
STATE STREET CORP $6,052,399 1,296,017 1.41% Shares
Woodline Partners LP $4,675,114 1,001,095 1.09% Shares
GOLDMAN SACHS GROUP INC $4,280,223 916,536 1.00% Shares
VANGUARD FIDUCIARY TRUST CO $2,671,417 572,038 0.62% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $2,531,738 542,128 0.59% Shares
Verdad Advisers, LP $1,644,274 352,093 0.38% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,229,443 263,264 0.29% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,168,901 250,300 0.27% Call option
Caption Management, LLC $1,167,500 250,000 0.27% Call option
Stonepine Capital Management, LLC $1,050,699 224,989 0.24% Shares
Affinity Asset Advisors, LLC $677,150 145,000 0.16% Shares
Nuveen, LLC $501,507 107,389 0.12% Shares
ALPS ADVISORS INC $447,040 95,726 0.10% Shares
RHUMBLINE ADVISERS $444,022 95,081 0.10% Shares
Susquehanna Portfolio Strategies, LLC $407,607 87,282 0.09% Shares
DEUTSCHE BANK AG\ $368,393 78,885 0.09% Shares
AMERICAN CENTURY COMPANIES INC $349,293 74,795 0.08% Shares
Bank of New York Mellon Corp $327,507 70,130 0.08% Shares
WELLS FARGO & COMPANY/MN $316,215 67,712 0.07% Shares
Palumbo Wealth Management LLC $313,432 67,116 0.07% Shares
Squarepoint Ops LLC $313,254 67,078 0.07% Shares
CITIGROUP INC $305,633 65,446 0.07% Shares
MetLife Investment Management, LLC $224,015 47,969 0.05% Shares
BANK OF AMERICA CORP /DE/ $218,841 46,861 0.05% Shares
Point72 Asset Management, L.P. $191,806 41,072 0.04% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $173,131 37,073 0.04% Shares
Jump Financial, LLC $159,961 34,253 0.04% Shares
Vanguard Global Advisers, LLC $154,003 32,977 0.04% Shares
Invesco Ltd. $150,575 32,243 0.04% Shares
JPMORGAN CHASE & CO $141,785 33,519 0.03% Shares
Police & Firemen's Retirement System of New Jersey $111,361 23,846 0.03% Shares
AXQ CAPITAL, LP $106,850 22,880 0.02% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $103,128 22,083 0.02% Shares
TWO SIGMA INVESTMENTS, LP $90,719 19,426 0.02% Shares
STIFEL FINANCIAL CORP $86,483 18,519 0.02% Shares
RENAISSANCE TECHNOLOGIES LLC $84,527 18,100 0.02% Shares
INTECH INVESTMENT MANAGEMENT LLC $80,744 17,290 0.02% Shares
WELLINGTON MANAGEMENT GROUP LLP $77,055 16,500 0.02% Shares
NEW YORK STATE COMMON RETIREMENT FUND $77,055 16,500 0.02% Shares
BNP PARIBAS FINANCIAL MARKETS $76,513 16,384 0.02% Shares
VOYA INVESTMENT MANAGEMENT LLC $73,963 15,838 0.02% Shares
BARCLAYS PLC $72,707 15,569 0.02% Shares
CAXTON CORP $72,650 15,557 0.02% Shares
WINTON GROUP Ltd $67,248 14,400 0.02% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $65,614 14,050 0.02% Shares
Creative Planning $64,782 13,872 0.02% Shares
BlackRock, Inc. $64,208 13,749 0.01% Shares
ALLIANCEBERNSTEIN L.P. $60,215 14,580 0.01% Shares
NORTHERN TRUST CORP $59,323 12,703 0.01% Shares
PRUDENTIAL FINANCIAL INC $58,375 12,500 0.01% Shares
ProShare Advisors LLC $49,445 10,588 0.01% Shares
Indivisible Partners $46,850 10,000 0.01% Shares
Pettinga Financial Advisors LLC $46,700 10,000 0.01% Shares
Legal & General Group Plc $36,697 7,858 0.01% Shares
Tower Research Capital LLC (TRC) $36,169 7,745 0.01% Shares
Ameritas Investment Partners, Inc. $34,268 7,338 0.01% Shares
ROYAL BANK OF CANADA $12,000 2,559 0.00% Shares
Point72 Asia (Singapore) Pte. Ltd. $9,966 2,914 0.00% Shares
PNC Financial Services Group, Inc. $8,215 1,759 0.00% Shares
Sterling Capital Management LLC $7,607 1,629 0.00% Shares
CIBC Private Wealth Group LLC $7,408 2,166 0.00% Shares
Russell Investments Group, Ltd. $3,404 729 0.00% Shares
GROUP ONE TRADING LLC $3,325 712 0.00% Shares
Bleichroeder LP $2,779 595 0.00% Shares
Blue Trust, Inc. $1,326 284 0.00% Shares
GSA CAPITAL PARTNERS LLP $356 76,314 0.00% Shares
PRICE T ROWE ASSOCIATES INC /MD/ $310 66,379 0.00% Shares
Rockefeller Capital Management L.P. $154 33 0.00% Shares
JONES FINANCIAL COMPANIES LLLP $153 38 0.00% Shares
UBS Group AG $149 32 0.00% Shares
Caitong International Asset Management Co., Ltd $140 30 0.00% Shares
SBI Securities Co., Ltd. $42 9 0.00% Shares
HighMark Wealth Management LLC $28 6 0.00% Shares

Company insiders 27 insiders · 7 officers · 17 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Paula Ragan President and CEO June 17, 2019 A 237,294 0 0 $0
Michael Gray President, CEO and CFO Nov. 27, 2018 A 250,000 0 0 $0
David Kirske Chief Financial Officer June 30, 2026 S 167,750 0 1 $-36,393
Adam S. Mostafa CFO and Treasurer June 17, 2019 A 10,564 0 0 $0
Lynne E Kelley Chief Medical Officer April 24, 2019 A 0 0 $0
Eszter Nagy Chief Scientific Officer March 7, 2018 A 0 0 $0
David Mantus Chief Development Officer March 7, 2018 A 0 0 $0
Kelly Gold Director July 1, 2026 A 0 0 $0
William Aliski Director Sept. 18, 2019 A 0 0 $0
Rene Russo Director June 17, 2019 A 0 0 $0
David W J Mcgirr Director June 17, 2019 A 0 0 $0
Murray Stewart Director March 29, 2019 A 0 0 $0
Gary Bridger Director March 13, 2019 A 0 0 $0
Michael S Wyzga Director March 13, 2019 A 0 0 $0
Isaac Blech Director March 13, 2019 A 0 0 $0
Tillman U. Gerngross Director June 5, 2018 A 392,821 0 0 $0
Claudio Nessi Director June 5, 2018 A 867,639 0 0 $0
Amy Schulman Director June 5, 2018 A 0 0 $0
William D Clark Director June 5, 2018 A 0 0 $0
GORDON CARL L Director June 5, 2018 A 1,868,966 0 0 $0
Terrance McGuire Director June 5, 2018 A 18,031 0 0 $0
Michael Jay Ross Director Nov. 15, 2017 A 1,868,961 0 0 $0
Anna-Maria & Stephen Kellen Foundation, Inc. 10% owner Nov. 20, 2017 C 124,381 0 0 $0
Bill & Melinda Gates Foundation 10% owner Nov. 20, 2017 C 722,179 0 0 $0
John Volpone Aug. 12, 2026 S 265,305 0 1 $-109,117
Adam R Craig Aug. 12, 2026 S 328,651 0 1 $-210,616
Anthony Chris Stevens March 7, 2018 A 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 10 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Growth Equity Opportunities 18 VGE, LLC, NEA 18 Venture Growth Equity, L.P., NEA Partners 18 VGE, L.P., NEA 18 VGE GP, LLC, Ali Behbahani, Carmen Chang, Anthony A. Florence, Jr., Mohamad H. Makhzoumi, Edward T. Mathers, Scott D. Sandell, Paul Walker, Rick Yang ×5 filings Oct. 29, 2025 6.20% Amendment Passive investment SEC
Coastlands Capital LP, Coastlands Capital Partners LP, Coastlands Capital GP LLC, Coastlands Capital LLC, Matthew D. Perry Aug. 18, 2025 9.99% Initial filing SEC
Bain Capital Life Sciences Fund, L.P., Bain Capital Life Sciences Fund II, L.P., BCIP Life Sciences Associates, LP, BCLS II Investco, LP, BCLS I Investco, LP Aug. 13, 2025 9.99% Initial filing SEC
Polaris Venture Partners V, L.P. (“PVP V”), Polaris Venture Partners Entrepreneurs’ Fund V, L.P. (“PVPE V”), Polaris Venture Partners Founders’ Fund V, L.P. (“PVPFF V”), Polaris Venture Partners Special Founders’ Fund V, L.P. (“PVPSFF V”), Polaris Venture Management Co. V, L.L.C. (“PVM V”), Jonathan A. Flint, Terrance G. McGuire ×2 filings July 17, 2019 Initial filing SEC
May 28, 2019 Initial filing SEC
Paula Ragan, Ph.D. ×2 filings April 26, 2019 Initial filing SEC
OrbiMed Advisors LLC, OrbiMed Capital GP IV LLC ×3 filings March 19, 2019 Initial filing SEC
X4 Pharmaceuticals, Inc. Dec. 6, 2018 Initial filing SEC
SVLSF V, LLC, SV Life Sciences Fund V, L.P., SV Life Sciences Fund V Strategic Partners, L.P., SV Life Sciences Fund V (GP), L.P., SVLSF VI, LLC, SV Life Sciences Fund VI, LP., SV Life Sciences Fund VI Strategic Partners, L.P., SV Life Sciences Fund VI (GP), L.P. Feb. 14, 2018 Initial filing SEC
New Enterprise Associates 16, L.P., NEA Partners 16, L.P., NEA 16 GP, LLC, Peter J. Barris, Forest Baskett, Anthony A. Florence, Jr., Mohamad H. Makhzoumi, Joshua Makower, David M. Mott, Chetan Puttagunta, Jon M. Sakoda, Scott D. Sandell, Peter W. Sonsini, Ravi Viswanathan Nov. 29, 2017 Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 13 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
QQQS · Invesco Exchange-Traded Fund Trust … 0.53% 25,945 SH Aug. 8, 2026 Daily
IWC · iShares Trust 0.08% 275,116 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.02% 750,719 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 70,293 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.01% 1,950,293 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 464,950 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.01% 46,744 NS May 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.00% 30,148 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.00% 1,031,672 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 2,599,387 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 6,885 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.00% 1 NS May 31, 2026 N-PORT
ITWO · ProShares Trust 0.00% 1 NS May 31, 2026 N-PORT