HALO Halozyme Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$103.55
Price · Aug 18, 2026
Fundamentals as of Aug 6, 2026

About Halozyme Therapeutics, Inc. - Common Stock Company overview from Wikipedia

HALO Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$103.55
Market Cap
$12.20B
P/E (TTM)
40.4
EPS (TTM)
$2.56
Revenue (TTM)
$1.40B
Div Yield
ROE
166.1%
Debt/Equity
43.9
52W Range
$61 – $105

HALO Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $1.40B
10-point trend, +852.1%
2016-12-31 2025-12-31
EPS $2.56
10-point trend, +416.0%
2016-12-31 2025-12-31
Free Cash Flow $645M
10-point trend, +1304.4%
2016-12-31 2025-12-31
Margins 22.7%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
HALO
Peer Median
P/E (TTM)
5-point trend, +79.1%
40.4
28.5
P/S (TTM)
5-point trend, -54.5%
8.7
20.1
P/B
5-point trend, +478.5%
249.9
12.9
EV / EBITDA
5-point trend, -8.2%
29.6
Price / FCF
5-point trend, -33.7%
18.9

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
HALO
Peer Median
Operating Margin
5-point trend, -46.0%
33.6%
Net Profit Margin
5-point trend, -75.0%
22.7%
-48.4%
ROA
5-point trend, -71.1%
13.8%
-28.4%
ROE
5-point trend, -1.3%
166.1%
-49.2%
ROIC
5-point trend, -65.1%
14.5%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
HALO
Peer Median
Debt / Equity
5-point trend, +886.1%
43.9
Current Ratio
5-point trend, -41.1%
4.7
5.0
Quick Ratio
5-point trend, +76.7%
3.2

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
HALO
Peer Median
Revenue YoY
5-point trend, +215.0%
37.5%
Revenue CAGR 3Y
5-point trend, +215.0%
28.4%
Revenue CAGR 5Y
5-point trend, +215.0%
39.2%
EPS YoY
5-point trend, -6.6%
-25.4%
Net Income YoY
5-point trend, -21.3%
-28.6%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
HALO
Peer Median
EPS (Diluted)
5-point trend, -6.6%
$2.56

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
HALO
Peer Median

HALO Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 16 analysts
  • Strong Buy 2 12.5%
  • Buy 10 62.5%
  • Hold 4 25.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

9 analysts · 2026-08-14
Median target $105.00 +1.4%
Mean target $99.56 -3.9%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.26%
Period EPS Actual EPS Est Surprise
June 30, 2026 $2.28 $1.87 0.41%
March 31, 2026 $1.60 $1.56 0.04%
Dec. 31, 2025 $-0.24 $2.24 -2.5%
Sept. 30, 2025 $1.72 $1.66 0.06%
June 30, 2025 $1.54 $1.29 0.25%
March 31, 2025 $1.11 $0.97 0.14%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
HALO $7.93B 26.3 37.5% 22.7% 166.1%
BBIO $14.90B -20.2 126.3% -146.0% 41.2%
BMRN $11.43B 33.0 12.9% 10.8% 5.8%
EXEL $11.44B 15.7 7.0% 33.7% 37.3%
ARWR $4.68B -3449.0 23258.2% -0.20% -0.50%
MDGL $13.30B -45.3 432.1% -30.1% -44.4%
PRAX $7.43B -21.9 249.5% -47.3%
CYTK $7.81B -9.7 376.6% -891.6% 152.7%
APGE $5.16B -17.9
PTGX $5.47B -42.6 -89.4% -282.8% -20.3%
KRYS $7.20B 36.0 33.9% 52.6% 18.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +1753.9% $1.40B $1.02B $829M $660M $443M $268M $196M $152M $317M $147M $135M $75M
Cost of Revenue 12-point trend, +906.4% $229M $159M $192M $139M $81M $43M $46M $10M $31M $33M $29M $23M
R&D Expense 11-point trend, -0.8% · $79M $76M $67M $36M $34M $141M $150M $151M $151M $93M $80M
SG&A Expense 12-point trend, +476.2% $207M $154M $149M $144M $50M $46M $77M $61M $54M $46M $40M $36M
Operating Expenses 10-point trend, +570.4% $928M $464M $492M $393M $167M $123M $264M · · $230M $163M $138M
Operating Income 12-point trend, +844.0% $469M $551M $338M $268M $276M $144M $-68M $-69M $81M $-83M $-27M $-63M
Interest Expense 10-point trend, +236.2% · · $19M $17M $8M $20M $12M $18M $22M $20M $5M $6M
Other Non-op 11-point trend, +4988.2% $21M $24M $16M $1M $1M $5M $7M $8M $3M $1M $422.0K ·
Pretax Income 12-point trend, +782.8% $467M $557M $348M $249M $249M $129M $-72M $-80M $62M $-102M $-32M $-68M
Income Tax 12-point trend, +149986000.00 $150M $113M $67M $47M $-154M $217.0K $-11.0K $537.0K $-1M $1M $0 $0
Net Income 12-point trend, +563.5% $317M $444M $282M $202M $403M $129M $-72M $-80M $63M $-103M $-32M $-68M
EPS (Basic) 11-point trend, +1156.0% $2.64 $3.50 $2.13 $1.48 $2.86 $0.95 $-0.50 $-0.56 $0.46 $-0.81 $-0.25 ·
EPS (Diluted) 11-point trend, +1124.0% $2.56 $3.43 $2.10 $1.44 $2.74 $0.91 $-0.50 $-0.56 $0.45 $-0.81 $-0.25 ·
Shares (Basic) 11-point trend, -5.4% 119,840,000 126,827,000 131,927,000 136,844,000 140,646,000 136,206,000 144,329,000 143,599,000 136,419,000 127,964,000 126,704,000 ·
Shares (Diluted) 11-point trend, -2.2% 123,904,000 129,424,000 134,197,000 140,608,000 146,796,000 141,463,000 144,329,000 143,599,000 139,068,000 127,964,000 126,704,000 ·
EBITDA 12-point trend, +884.0% $480M $562M $349M $274M $279M $148M $-64M $-67M $83M $-81M $-26M $-61M
Balance Sheet 26
Annual Balance Sheet data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +118.0% $134M $116M $118M $234M $119M $148M $120M $58M $169M $67M $43M $61M
Short-term Investments 6-point trend, +305.6% · · · · · · $301M $297M $300M $138M $65M $74M
Receivables 12-point trend, +4559.2% $426M $288M $233M $187M $91M $98M $59M $30M $22M $16M $32M $9M
Inventory 12-point trend, +2654.8% $176M $142M $128M $100M $54M $61M $29M $23M $5M $15M $9M $6M
Prepaid Expense 12-point trend, +537.3% $65M $39M $49M $45M $40M $28M $33M $21M $14M $21M $22M $10M
Current Assets 12-point trend, +411.5% $825M $1.09B $746M $739M $926M $555M $543M $428M $510M $257M $172M $161M
PP&E (Net) 12-point trend, +1406.0% $44M $41M $38M $35M $7M $7M $11M $7M $4M $4M $4M $3M
PP&E (Gross) 12-point trend, +537.6% $78M $66M $58M $50M $20M $19M $18M $24M $17M $16M $14M $12M
Accum. Depreciation 11-point trend, +259.7% $33M $25M $20M $15M $13M $12M · $16M $14M $12M $10M $9M
Goodwill 5-point trend, +580360000.00 $580M $417M $417M $409M $0 · · · · · · ·
Intangibles 5-point trend, +981467000.00 $981M $402M $473M $547M $0 · · · · · · ·
Total Assets 12-point trend, +1421.5% $2.53B $2.06B $1.73B $1.84B $1.10B $580M $566M $440M $520M $262M $182M $166M
Accounts Payable 12-point trend, +595.9% $21M $10M $12M $18M $2M $2M $6M $4M $8M $4M $4M $3M
Accrued Liabilities 12-point trend, +1018.8% $156M $129M $101M $100M $24M $20M $56M $50M $40M $29M $27M $14M
Current Liabilities 12-point trend, +627.8% $177M $139M $112M $131M $117M $421M $86M $149M $131M $55M $62M $24M
Deferred Tax 10-point trend, +22025.8% $43M $0 $0 · $0 · $16M $858.0K $173.0K $340.0K $380.0K $194.0K
Other Non-current Liabilities 12-point trend, +3495.3% $114M $55M $38M $33M $544.0K $3M $4M $2M $814.0K $358.0K $4M $3M
Total Liabilities 4-point trend, +48.1% $2.48B $1.70B $1.65B $1.67B · · · · · · · ·
Long-term Debt 12-point trend, +4197.3% $2.14B $1.51B $1.50B $1.51B $787M $0 $383M $35M $125M $199M $28M $50M
Total Debt 12-point trend, +4197.3% $2.14B $1.51B $1.50B $1.51B $877M $397M $403M $126M $202M $217M $50M $50M
Common Stock 12-point trend, -6.3% $118.0K $123.0K $127.0K $135.0K $138.0K $135.0K $137.0K $145.0K $143.0K $130.0K $128.0K $126.0K
Retained Earnings 12-point trend, +112.2% $55M $360M $91M $143M $-59M $-475M $-604M $-531M $-522M $-585M $-483M $-450M
AOCI 12-point trend, -44026.8% $-18M $4M $-9M $-922.0K $-620.0K $22.0K $240.0K $-277.0K $-450.0K $-6.0K $-99.0K $-41.0K
Stockholders' Equity 12-point trend, +18.0% $49M $364M $84M $170M $197M $151M $92M $249M $208M $-32M $43M $41M
Liabilities + Equity 12-point trend, +1421.5% $2.53B $2.06B $1.73B $1.84B $1.10B $580M $566M $440M $520M $262M $182M $166M
Shares Outstanding 12-point trend, -6.3% 117,782,000 123,138,000 126,770,000 135,154,000 137,498,000 135,030,000 136,712,580 144,725,164 142,789,000 129,502,000 128,152,000 125,721,000
Cash Flow 15
Annual Cash Flow data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, +546.4% $11M $10M $11M $6M $3M $3M $4M $2M $2M $2M $2M $2M
Stock-based Comp 12-point trend, +237.6% $52M $43M $37M $24M $21M $17M $35M $36M $31M $26M $21M $15M
Amort. of Intangibles 6-point trend, +76662000.00 $77M $71M $74M $43M $0 $0 · · · · · ·
Other Non-cash 12-point trend, +7011.1% $272M $-19M $59M $7M $-127M $-94M $-52M $-7M $38M $25M $-27M $4M
Operating Cash Flow 12-point trend, +1471.2% $652M $479M $389M $240M $299M $55M $-85M $-50M $134M $-50M $-37M $-48M
CapEx 12-point trend, +409.5% $7M $11M $15M $5M $1M $3M $4M $5M $1M $3M $2M $1M
Investing Cash Flow 12-point trend, -1556.4% $-546M $-263M $-97M $-487M $-406M $78M $-6M $2M $-164M $-77M $6M $-33M
Stock Issued 6-point trend, -100.0% · · · · · · $0 $0 $135M $0 $0 $108M
Stock Repurchased 9-point trend, +342372000.00 $342M $250M $402M $200M $350M $150M $200M $0 $0 · · ·
Net Stock Activity 12-point trend, -417.9% $-342M $-250M $-402M $-200M $-350M $-150M $-200M $0 $135M $0 $0 $108M
Financing Cash Flow 12-point trend, -174.4% $-85M $-219M $-408M $362M $78M $-106M $153M $-64M $132M $151M $13M $115M
Net Change in Cash 12-point trend, -39.6% $21M $-3M $-116M $115M $-29M $28M $62M $-111M $102M $23M $-18M $34M
Taxes Paid 6-point trend, +74700.6% $135M $81M $32M $16M $-375.0K $180.0K · · · · · ·
Free Cash Flow 12-point trend, +1418.6% $645M $468M $373M $235M $298M $53M $-89M $-54M $133M $-54M $-39M $-49M
Levered FCF 8-point trend, +585.7% · · $358M $222M $286M $33M $-101M $-72M $110M $-74M · ·
Profitability 7
Annual Profitability data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 10-point trend, +140.1% 33.6% 54.3% 40.7% 40.5% 62.2% · · -45.6% 25.6% -56.7% -20.3% -83.7%
Net Margin 10-point trend, +125.0% 22.7% 43.7% 34.0% 30.6% 90.8% · · -52.9% 19.9% -70.2% -23.9% -90.8%
Pretax Margin 8-point trend, +148.1% 33.4% 54.9% 42.0% 37.7% 56.1% · · -52.5% 19.5% -69.4% · ·
EBITDA Margin 10-point trend, +142.3% 34.4% 55.3% 42.0% 41.5% 62.9% · · -44.1% 26.3% -55.1% -19.1% -81.3%
ROA 12-point trend, +127.0% 13.8% 23.4% 15.8% 13.7% 47.8% 22.5% -14.4% -16.7% 16.1% -46.5% -18.5% -51.1%
ROE 12-point trend, +125.9% 166.1% 108.8% 169.1% 151.5% 168.3% 103.2% -42.9% -32.9% 71.6% -1959.0% -76.4% -640.2%
ROIC 10-point trend, +131.8% 14.5% 23.5% 17.2% 13.0% 41.6% 26.3% -13.7% -18.6% 20.2% -45.7% · ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 12-point trend, -29.7% 4.7 7.8 6.6 5.7 7.9 1.3 6.3 2.9 3.9 4.7 2.8 6.6
Quick Ratio 12-point trend, -46.8% 3.2 2.9 1.1 3.6 1.8 0.6 5.6 2.6 3.7 4.0 2.3 6.0
Debt / Equity 12-point trend, +3540.5% 43.9 4.1 17.9 8.9 4.5 2.6 4.4 0.5 1.0 -6.7 1.2 1.2
LT Debt / Equity 12-point trend, +3540.5% 43.9 4.1 17.9 8.8 4.0 0.0 4.2 0.1 0.6 -6.1 0.7 1.2
Interest Coverage 10-point trend, +259.3% · · 18.0 15.8 36.7 7.1 -5.8 -3.8 3.7 -4.2 -5.3 -11.3
Efficiency 3
Annual Efficiency data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 10-point trend, +8.2% 0.6 0.5 0.5 0.4 0.5 · · 0.3 0.8 0.7 0.8 0.6
Inventory Turnover 12-point trend, -60.2% 1.4 1.2 1.7 1.8 1.4 1.0 1.8 0.7 3.2 2.8 3.7 3.6
Receivables Turnover 9-point trend, -52.7% 3.9 3.9 · 4.1 4.7 · · 5.8 16.7 6.1 6.5 8.3
Per Share 5
Annual Per Share data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 12-point trend, +26.0% $0.41 $2.95 $0.66 $1.26 $1.43 $1.12 $0.67 $1.74 $1.46 $-0.25 $0.34 $0.33
Revenue / Share 7-point trend, +395.1% $11.27 $7.84 $6.18 $4.69 $3.02 · · $1.06 $2.28 · · ·
Cash Flow / Share 9-point trend, +445.6% $5.26 $3.70 $2.90 $1.71 $2.04 $0.39 $-0.59 $-0.34 $0.96 · · ·
Cash / Share 12-point trend, +132.7% $1.14 $0.94 $0.93 $1.73 $0.86 $1.09 $0.88 $0.41 $1.18 $0.52 $0.34 $0.49
EPS (TTM) 11-point trend, +1124.0% $2.56 $3.43 $2.10 $1.44 $2.74 $0.91 $-0.50 $-0.56 $0.45 $-0.81 $-0.25 ·
Growth Rates 9
Annual Growth Rates data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -42.8% 37.5% 22.4% 25.6% 48.9% 65.7% · · · · · · ·
Revenue CAGR 3Y 3-point trend, -38.0% 28.4% 31.8% 45.8% · · · · · · · · ·
Revenue CAGR 5Y 39.2% · · · · · · · · · · ·
EPS YoY 5-point trend, -112.6% -25.4% 63.3% 45.8% -47.4% 201.1% · · · · · · ·
EPS CAGR 3Y 3-point trend, -34.2% 21.1% 7.8% 32.1% · · · · · · · · ·
EPS CAGR 5Y 23.0% · · · · · · · · · · ·
Net Income YoY 5-point trend, -113.5% -28.6% 57.7% 39.3% -49.8% 212.0% · · · · · · ·
Net Income CAGR 3Y 3-point trend, -45.5% 16.2% 3.3% 29.7% · · · · · · · · ·
Net Income CAGR 5Y 19.7% · · · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for HALO
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +1753.9% $1.40B $1.02B $829M $660M $443M $268M $196M $152M $317M $147M $135M $75M
Net Income TTM 12-point trend, +563.5% $317M $444M $282M $202M $403M $129M $-72M $-80M $63M $-103M $-32M $-68M
Market Cap 12-point trend, +553.4% $7.93B $5.89B $4.69B $7.69B $5.53B $5.77B $2.42B $2.09B $2.89B $1.28B $2.22B $1.21B
Enterprise Value 12-point trend, +781.2% $9.94B $7.28B $6.07B $8.96B $6.29B $6.02B $2.41B $1.86B $2.63B $1.29B $2.16B $1.13B
P/E 11-point trend, +137.9% 26.3 13.9 17.6 39.5 14.7 46.9 -35.5 -26.1 45.0 -12.2 -69.3 ·
P/S 12-point trend, -64.8% 5.7 5.8 5.7 11.6 12.5 21.6 12.4 13.8 9.1 8.7 16.4 16.1
P/B 12-point trend, +453.5% 162.4 16.2 55.9 45.3 28.1 38.2 26.4 8.4 13.9 -39.4 51.6 29.3
P / Tangible Book 2-point trend, -26.5% · · · · 28.1 38.2 · · · · · ·
P / Cash Flow 12-point trend, +147.7% 12.2 12.3 12.1 32.0 18.5 104.0 -28.4 -42.2 21.6 -25.4 -59.9 -25.5
P / FCF 12-point trend, +149.6% 12.3 12.6 12.6 32.7 18.6 108.9 -27.1 -38.6 21.8 -23.9 -56.3 -24.8
EV / EBITDA 12-point trend, +212.4% 20.7 13.0 17.4 32.7 22.5 40.8 -37.9 -27.8 31.6 -16.0 -83.9 -18.4
EV / FCF 12-point trend, +166.8% 15.4 15.5 16.3 38.1 21.1 113.6 -26.9 -34.4 19.8 -24.1 -54.8 -23.1
EV / Revenue 12-point trend, -52.5% 7.1 7.2 7.3 13.6 14.2 22.5 12.3 12.3 8.3 8.8 16.0 15.0
Earnings Yield 11-point trend, +363.9% 3.8% 7.2% 5.7% 2.5% 6.8% 2.1% -2.8% -3.8% 2.2% -8.2% -1.4% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $1.40B$1.02B$829M$660M$443M
Operating Margin % 33.6%54.3%40.7%40.5%62.2%
Net Income $317M$444M$282M$202M$403M
Diluted EPS $2.56$3.43$2.10$1.44$2.74
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 43.94.117.98.94.5
Current Ratio 4.77.86.65.77.9
Quick Ratio 3.22.91.13.61.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $645M$468M$373M$235M$298M

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Institutional owners (13F) 723 filers · $5.8B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
101 (-11 vs prior Q) 62 (0 vs prior Q) 257 (+32 vs prior Q) 201 (-8 vs prior Q) +11.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
VANGUARD CAPITAL MANAGEMENT LLC $418,847,190 5,351,312 7.23% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $414,753,356 5,299,008 7.15% Shares
STATE STREET CORP $405,379,779 5,179,434 6.99% Shares
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC $196,539,884 2,511,050 3.39% Shares
SNYDER CAPITAL MANAGEMENT L P $187,542,825 2,396,101 3.24% Shares
GEODE CAPITAL MANAGEMENT, LLC $161,871,438 2,067,539 2.79% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $151,690,000 1,938,035 2.62% Shares
DIMENSIONAL FUND ADVISORS LP $149,867,562 1,914,752 2.59% Shares
BANK OF AMERICA CORP /DE/ $141,963,308 1,813,764 2.45% Shares
ROYAL LONDON ASSET MANAGEMENT LTD $141,732,491 1,810,815 2.44% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $133,420,842 1,704,623 2.30% Shares
TWO SIGMA INVESTMENTS, LP $129,402,617 1,653,285 2.23% Shares
FULLER & THALER ASSET MANAGEMENT, INC. $116,700,910 1,491,004 2.01% Shares
NORGES BANK $116,125,129 1,483,648 2.00% Shares
FIRST TRUST ADVISORS LP $110,913,469 1,417,063 1.91% Shares
ALLIANCEBERNSTEIN L.P. $109,647,251 1,696,538 1.89% Shares
Stephens Investment Management Group LLC $109,015,943 1,392,819 1.88% Shares
CONGRESS ASSET MANAGEMENT CO $96,202,127 1,229,106 1.66% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $92,656,000 1,183,799 1.60% Shares
TD Asset Management Inc $87,328,187 1,115,730 1.51% Shares
Caisse de depot et placement du Quebec $83,939,801 1,072,439 1.45% Shares
Assenagon Asset Management S.A. $78,085,518 997,643 1.35% Shares
Mizuho Markets Cayman LP $65,316,315 834,500 1.13% Shares
VANGUARD FIDUCIARY TRUST CO $59,930,713 765,692 1.03% Shares
Gotham Asset Management, LLC $57,862,898 739,273 1.00% Shares
Boston Trust Walden Corp $49,923,111 637,832 0.86% Shares
KENNEDY CAPITAL MANAGEMENT LLC $42,656,680 544,994 0.74% Shares
BNP PARIBAS FINANCIAL MARKETS $41,396,142 528,889 0.71% Shares
VICTORY CAPITAL MANAGEMENT INC $40,477,956 517,158 0.70% Shares
RENAISSANCE TECHNOLOGIES LLC $37,539,153 479,611 0.65% Shares
Bridgewater Associates, LP $36,250,437 463,146 0.63% Shares
RENAISSANCE GROUP LLC $35,005,643 447,242 0.60% Shares
JANUS HENDERSON GROUP PLC $33,624,985 520,269 0.58% Shares
Fisher Asset Management, LLC $33,477,096 427,713 0.58% Shares
Arbejdsmarkedets Tillaegspension $32,505,531 415,300 0.56% Shares
MetLife Investment Management, LLC $31,511,893 402,605 0.54% Shares
MIZUHO MARKETS AMERICAS LLC $30,766,450 393,081 0.53% Shares
Retirement Systems of Alabama $27,586,575 352,454 0.48% Shares
FRONTIER CAPITAL MANAGEMENT CO LLC $26,812,936 342,570 0.46% Shares
RHUMBLINE ADVISERS $25,886,502 330,734 0.45% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $25,232,448 322,377 0.44% Shares
OBERWEIS ASSET MANAGEMENT INC/ $25,127,018 321,030 0.43% Shares
SEGALL BRYANT & HAMILL, LLC $24,883,911 317,924 0.43% Shares
GOLDMAN SACHS GROUP INC $24,435,268 312,192 0.42% Shares
CITADEL ADVISORS LLC $22,627,074 289,090 0.39% Shares
California Public Employees Retirement System $22,124,737 282,672 0.38% Shares
ENVESTNET ASSET MANAGEMENT INC $21,063,640 269,115 0.36% Shares
PRINCIPAL FINANCIAL GROUP INC $20,978,160 268,023 0.36% Shares
NEUBERGER BERMAN GROUP LLC $20,761,665 265,257 0.36% Shares
Cresset Asset Management, LLC $20,423,539 260,937 0.35% Shares
AMERIPRISE FINANCIAL INC $20,048,470 256,145 0.35% Shares
BARCLAYS PLC $20,036,650 255,994 0.35% Shares
South Street Advisors LLC $18,682,188 238,689 0.32% Shares
Swiss National Bank $18,604,779 237,700 0.32% Shares
Clark Capital Management Group, Inc. $18,155,197 231,956 0.31% Shares
RAYMOND JAMES FINANCIAL INC $17,432,216 222,719 0.30% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $16,010,601 204,556 0.28% Shares
LPL Financial LLC $15,932,385 203,557 0.27% Shares
Swedbank AB $15,838,874 202,362 0.27% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $14,832,165 189,500 0.26% Call option
Corient Private Wealth LP $14,671,472 187,447 0.25% Shares
KORNITZER CAPITAL MANAGEMENT INC /KS $14,587,571 186,375 0.25% Shares
Mesirow Institutional Investment Management, Inc. $14,445,696 302,148 0.25% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $14,032,868 181,820 0.24% Shares
BlackRock, Inc. $13,794,774 176,246 0.24% Shares
ASSETMARK, INC $13,645,122 174,334 0.24% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $13,623,754 174,061 0.24% Shares
Quantinno Capital Management LP $13,037,160 166,566 0.22% Shares
Susquehanna Portfolio Strategies, LLC $13,032,190 166,503 0.22% Shares
Focus Partners Wealth $12,760,854 163,036 0.22% Shares
Congress Wealth Management LLC / DE / $12,754,131 245,177 0.22% Shares
INTECH INVESTMENT MANAGEMENT LLC $12,702,594 162,292 0.22% Shares
Glenmede Investment Management, LP $12,666,624 172,711 0.22% Shares
HARVEY CAPITAL MANAGEMENT INC $11,436,265 146,113 0.20% Shares
UBS Group AG $11,319,173 144,617 0.20% Shares
Future Fund LLC $11,114,888 142,007 0.19% Shares
GLENMEDE TRUST CO NA $10,836,090 138,445 0.19% Shares
Hudson Bay Capital Management LP $10,566,450 135,000 0.18% Shares
CANADA PENSION PLAN INVESTMENT BOARD $10,378,602 132,600 0.18% Shares
Hodges Capital Management Inc. $10,337,197 132,071 0.18% Shares
Portolan Capital Management, LLC $9,979,268 127,498 0.17% Shares
MARSHALL WACE, LLP $9,882,683 126,264 0.17% Shares
CAPTRUST FINANCIAL ADVISORS $9,857,805 125,946 0.17% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $9,783,750 125,000 0.17% Put option
LAZARD ASSET MANAGEMENT LLC $9,185,767 117,360 0.16% Shares
Panoramic Capital, LLC $9,111,880 116,416 0.16% Shares
VANGUARD ASSET MANAGEMENT, Ltd $8,892,646 113,615 0.15% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $8,812,042 136,346 0.15% Shares
TWO SIGMA ADVISERS, LP $8,695,160 129,200 0.15% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $8,565,477 109,435 0.15% Shares
Steamboat Capital Partners, LLC $8,481,807 108,366 0.15% Shares
Artemis Investment Management LLP $8,475,389 108,284 0.15% Shares
AMERICAN CENTURY COMPANIES INC $8,423,339 107,619 0.15% Shares
D. E. Shaw & Co., Inc. $8,406,981 107,410 0.15% Shares
Woodline Partners LP $8,152,760 104,162 0.14% Shares
CITADEL ADVISORS LLC $7,725,249 98,700 0.13% Call option
Cutter Capital Management, LP $7,657,200 120,000 0.13% Shares
ArrowMark Colorado Holdings LLC $7,610,192 97,230 0.13% Shares
Livforsakringsbolaget Skandia, Omsesidigt $7,503,543 116,100 0.13% Shares
FIFTH THIRD BANCORP $7,488,901 95,681 0.13% Shares

Company insiders 46 insiders · 24 officers · 16 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Helen Torley PRESIDENT AND CEO July 8, 2026 M 767,780 0 55 $-22,823,911
Gregory Ian Frost CEO, President Aug. 12, 2013 M 3,591,380 0 0 $0
Darren Snellgrove SVP, Chief Financial Officer July 1, 2026 A 0 0 $0
Nicole Labrosse SVP, CHIEF FINANCIAL OFFICER Feb. 23, 2026 M 38,494 0 0 $0
Laurie Stelzer SVP, Chief Financial Officer Feb. 22, 2020 M 116,167 0 0 $0
Kurt A Gustafson VP, Chief Financial Officer Feb. 2, 2012 A 0 0 $0
Cortney Caudill SVP, CHIEF OPERATING OFFICER March 10, 2026 M 7,055 0 4 $-2,233,042
Mark J Gergen SVP, Chief Operating Officer Feb. 22, 2017 A 0 0 $0
David A Ramsay EVP, PRESIDENT, DRUG DELIVERY July 1, 2026 A 4,592 0 0 $0
Mark Howard Snyder SVP, CHIEF LEGAL OFFICER June 12, 2026 M 49,929 0 0 $0
Michael J. Labarre SVP, Chief Technical Officer Feb. 16, 2022 A 173,137 0 0 $0
Masaru Matsuda SVP, General Counsel Sept. 4, 2021 M 20,049 0 0 $0
Benjamin Hickey SVP, Chief Commerical Officer Oct. 1, 2019 M 13,226 0 0 $0
Dimitrios Chondros SVP, Chief Medical Officer Aug. 3, 2019 S 38,584 0 0 $0
Alison A. Armour SVP, Research & Development June 3, 2019 A 0 0 $0
Harry J Leonhardt SVP, GC April 13, 2019 M 66,373 0 0 $0
Athena Countouriotis SVP and Chief Medical Officer Feb. 22, 2017 A 39,077 0 0 $0
James P Shaffer VP & Chief Commercial Officer Feb. 6, 2014 A 54,025 0 0 $0
Jean I Liu VP & General Counsel Feb. 6, 2014 A 20,869 0 0 $0
Michael H. Shepard VP & Chief Scientific Officer Feb. 2, 2012 A 0 0 $0
William J Fallon VP, Manufacturing & Operations May 10, 2011 A 0 0 $0
Richard C Yocum VP Clinical Development March 21, 2007 M 65,975 0 0 $0
Don A Kennard Vice President, Regulatory Aff Feb. 5, 2007 A 3,000 0 0 $0
Carolyn Rynard Vice President Feb. 9, 2005 M 100,000 0 0 $0
Mahesh Krishnan Director June 29, 2026 M 14,462 0 1 $-547,800
James Paul Lang Director May 5, 2026 A 4,685 0 0 $0
Matthew L. Posard Director May 5, 2026 A 77,835 0 0 $0
Barbara Gayle Duncan Director May 5, 2026 A 23,715 0 0 $0
Jeffrey William Henderson Director May 5, 2026 A 36,572 0 0 $0
Jean-Pierre Bizzari Director May 5, 2022 A 58,750 0 0 $0
Akiko Moni Miyashita Director May 5, 2022 A 6,206 0 0 $0
James M Daly Director May 5, 2022 A 32,438 0 0 $0
Connie Matsui Director May 5, 2022 A 188,189 0 0 $0
Kenneth J Kelley Director April 14, 2021 S 179,833 0 0 $0
Kathryn E Falberg Director May 4, 2016 A 358,253 0 0 $0
John Stuart Patton Director Aug. 19, 2014 M 179,876 0 0 $0
Robert L Engler MD Director Aug. 14, 2014 M 273,176 0 0 $0
Steven T Thornton Director June 15, 2007 M 15,000 0 0 $0
RANDAL J. KIRK 10% owner July 27, 2018 S 3,616,655 0 0 $0
Bernadette Connaughton Aug. 10, 2026 S 40,418 0 8 $-839,371
Elaine D Sun April 1, 2021 M 14,018 0 0 $0
Jonathan E Lim Feb. 5, 2009 A 700,000 0 0 $0
Robert J Little Feb. 5, 2009 A 4,000 0 0 $0
Matthew Hooper Nov. 12, 2007 A 0 0 $0
Mitch Keeler March 10, 2004 J 15,000 0 0 $0
Mellissa Day March 10, 2004 J 999 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
RANDAL J. KIRK ×14 filings Nov. 5, 2019 Initial filing SEC
Undisclosed reporting person May 6, 2004 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 122 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
PBE · Invesco Exchange-Traded Fund Trust 3.59% 126,229 SH Aug. 8, 2026 Daily
SCAP · Series Portfolios Trust 2.81% 8,596 NS May 31, 2026 N-PORT
GRPM · Invesco Exchange-Traded Fund Trust 2.70% 133,133 SH Aug. 8, 2026 Daily
RFG · Invesco Exchange-Traded Fund Trust 2.46% 85,715 SH Aug. 8, 2026 Daily
CSMD · Professionally Managed Portfolios 2.30% 156,567 NS April 30, 2026 N-PORT
AZTD · Tidal Trust I 1.76% 12,120 NS April 30, 2026 N-PORT
BBP · ETFis Series Trust I 1.63% 15,211 NS April 30, 2026 N-PORT
FFND · Northern Lights Fund Trust II 1.39% 21,462 NS May 31, 2026 N-PORT
JMID · Janus Detroit Street Trust 1.26% 3,618 NS April 30, 2026 N-PORT
CANC · Tema ETF Trust 1.23% 32,598 NS May 31, 2026 N-PORT
SAWS · ETF Series Solutions 1.11% 1,232 NS April 30, 2026 N-PORT
BUL · Pacer Funds Trust 0.94% 18,816 NS April 30, 2026 N-PORT
JSMD · Janus Detroit Street Trust 0.94% 144,590 NS April 30, 2026 N-PORT
ILDR · First Trust Exchange-Traded Fund VI… 0.93% 40,132 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.90% 73,023 NS April 30, 2026 N-PORT
ROE · EA Series Trust 0.87% 33,876 NS May 29, 2026 N-PORT
ALIL · EA Series Trust 0.86% 3,320 NS May 29, 2026 N-PORT
FXH · First Trust Exchange-Traded AlphaDE… 0.85% 117,113 NS April 30, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.83% 6,454 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.78% 862,036 SH Aug. 8, 2026 Daily
COWG · Pacer Funds Trust 0.74% 253,492 NS April 30, 2026 N-PORT
AFMC · First Trust Exchange-Traded Fund VI… 0.64% 15,633 NS May 31, 2026 N-PORT
LSEQ · Harbor ETF Trust 0.59% 1,427 NS April 30, 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0.58% 4,569 NS May 31, 2026 N-PORT
AGNG · Global X Funds 0.56% 6,843 NS May 31, 2026 N-PORT
IJK · iShares Trust 0.54% 693,226 SH Aug. 8, 2026 Daily
IVOG · VANGUARD ADMIRAL FUNDS 0.49% 117,038 SH Aug. 8, 2026 Daily
SMDX · Tidal Trust III 0.46% 9,165 NS April 30, 2026 N-PORT
SIXL · EXCHANGE TRADED CONCEPTS TRUST 0.43% 12,111 NS May 31, 2026 N-PORT
NUSC · Nushares ETF Trust 0.43% 86,197 NS April 30, 2026 N-PORT
ABOT · Abacus FCF ETF Trust 0.41% 282 NS April 30, 2026 N-PORT
BIB · ProShares Trust 0.39% 4,364 NS May 31, 2026 N-PORT
FNY · First Trust Exchange-Traded AlphaDE… 0.39% 31,828 NS April 30, 2026 N-PORT
QGRO · AMERICAN CENTURY ETF TRUST 0.38% 125,473 NS May 31, 2026 N-PORT
AFSM · First Trust Exchange-Traded Fund VI… 0.35% 5,253 NS May 31, 2026 N-PORT
QVMM · Invesco Exchange-Traded Fund Trust … 0.34% 14,758 SH Aug. 8, 2026 Daily
JPME · J.P. Morgan Exchange-Traded Fund Tr… 0.34% 23,144 NS April 30, 2026 N-PORT
SMLF · iShares Trust 0.33% 161,079 SH Aug. 8, 2026 Daily
XJH · iShares Trust 0.32% 16,037 SH Aug. 8, 2026 Daily
ISCV · iShares Trust 0.32% 26,095 SH Aug. 8, 2026 Daily
MIDE · DBX ETF Trust 0.31% 158 NS May 29, 2026 N-PORT
IQSM · New York Life Investments ETF Trust 0.31% 15,405 NS April 30, 2026 N-PORT
SMMV · iShares Trust 0.30% 10,318 SH Aug. 8, 2026 Daily
GQQQ · EA Series Trust 0.29% 6,432 NS May 29, 2026 N-PORT
IWP · iShares Trust 0.29% 678,051 SH Aug. 8, 2026 Daily
IJH · iShares Trust 0.28% 4,092,514 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.27% 74,228 SH Aug. 8, 2026 Daily
VBK · VANGUARD INDEX FUNDS 0.25% 1,570,798 SH Aug. 8, 2026 Daily
IVOO · VANGUARD ADMIRAL FUNDS 0.25% 191,789 SH Aug. 8, 2026 Daily
JPUS · J.P. Morgan Exchange-Traded Fund Tr… 0.24% 16,701 NS April 30, 2026 N-PORT