KPTI — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $18,732,549 | 1,917,354 | 8.69% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $14,863,316 | 1,521,322 | 6.89% | Shares |
| ACORN CAPITAL ADVISORS, LLC | $14,831,964 | 1,518,113 | 6.88% | Shares |
| GOLDMAN SACHS GROUP INC | $13,918,908 | 1,424,658 | 6.46% | Shares |
| BlackRock, Inc. | $13,861,666 | 1,418,799 | 6.43% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $9,369,225 | 958,979 | 4.35% | Shares |
| Catalio Capital Management, LP | $9,192,153 | 940,855 | 4.26% | Shares |
| Avidity Partners Management LP | $9,032,238 | 924,487 | 4.19% | Shares |
| TWO SIGMA INVESTMENTS, LP | $6,792,729 | 695,264 | 3.15% | Shares |
| Kalehua Capital Management LLC | $6,698,742 | 685,644 | 3.11% | Shares |
| NEA Management Company, LLC | $5,635,141 | 576,780 | 2.61% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $5,191,417 | 531,231 | 2.41% | Shares |
| Ghisallo Capital Management LLC | $4,885,000 | 500,000 | 2.27% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4,736,496 | 484,800 | 2.20% | Call option |
| Soleus Capital Management, L.P. | $4,298,800 | 440,000 | 1.99% | Shares |
| VANGUARD GROUP INC | $4,118,796 | 559,619 | 1.91% | Shares |
| UBS Group AG | $3,454,135 | 353,545 | 1.60% | Shares |
| STATE STREET CORP | $3,184,932 | 325,991 | 1.48% | Shares |
| Affinity Asset Advisors, LLC | $3,053,125 | 312,500 | 1.42% | Shares |
| Brevan Howard Capital Management LP | $3,026,912 | 309,817 | 1.40% | Shares |
| MILLENNIUM MANAGEMENT LLC | $2,986,455 | 305,676 | 1.39% | Shares |
| Boxer Capital Management, LLC | $2,955,777 | 302,536 | 1.37% | Shares |
| Davidson Kempner Capital Management LP | $2,931,000 | 300,000 | 1.36% | Shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | $2,906,184 | 297,460 | 1.35% | Shares |
| Caption Management, LLC | $2,791,289 | 285,700 | 1.29% | Call option |
| Eversept Partners, LP | $2,698,220 | 276,174 | 1.25% | Shares |
| Tetragon Partners GP Ltd | $2,445,431 | 250,300 | 1.13% | Call option |
| JPMORGAN CHASE & CO | $2,093,737 | 207,609 | 0.97% | Shares |
| MORGAN STANLEY | $1,978,485 | 202,506 | 0.92% | Shares |
| Trexquant Investment LP | $1,840,355 | 188,368 | 0.85% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $1,837,131 | 188,038 | 0.85% | Shares |
| BARCLAYS PLC | $1,620,882 | 165,904 | 0.75% | Shares |
| NORTHERN TRUST CORP | $1,563,258 | 160,006 | 0.73% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $1,420,568 | 145,401 | 0.66% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1,317,172 | 134,818 | 0.61% | Shares |
| MARSHALL WACE, LLP | $1,254,967 | 128,451 | 0.58% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $1,057,251 | 108,214 | 0.49% | Shares |
| DLD Asset Management, LP | $989,625 | 101,500 | 0.46% | Put option |
| SILVERBACK ASSET MANAGEMENT LLC | $977,000 | 100,000 | 0.45% | Call option |
| Jump Financial, LLC | $918,380 | 94,000 | 0.43% | Shares |
| Caption Management, LLC | $903,725 | 92,500 | 0.42% | Put option |
| Invesco Ltd. | $882,270 | 90,304 | 0.41% | Shares |
| DLD Asset Management, LP | $780,975 | 80,100 | 0.36% | Call option |
| Connor, Clark & Lunn Investment Management Ltd. | $746,399 | 76,397 | 0.35% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $702,199 | 71,873 | 0.33% | Shares |
| J. Goldman & Co LP | $660,452 | 67,600 | 0.31% | Put option |
| TWO SIGMA ADVISERS, LP | $660,405 | 89,729 | 0.31% | Shares |
| J. Goldman & Co LP | $659,475 | 67,500 | 0.31% | Shares |
| Squarepoint Ops LLC | $623,336 | 63,801 | 0.29% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $605,183 | 61,943 | 0.28% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $594,993 | 60,900 | 0.28% | Put option |
| ROYAL BANK OF CANADA | $590,000 | 60,430 | 0.27% | Shares |
| Bank of New York Mellon Corp | $559,446 | 57,262 | 0.26% | Shares |
| Susquehanna Portfolio Strategies, LLC | $532,905 | 54,545 | 0.25% | Shares |
| XTX Topco Ltd | $520,467 | 53,272 | 0.24% | Shares |
| CITADEL ADVISORS LLC | $509,994 | 52,200 | 0.24% | Call option |
| CITADEL ADVISORS LLC | $508,714 | 52,069 | 0.24% | Shares |
| BANK OF AMERICA CORP /DE/ | $487,758 | 49,924 | 0.23% | Shares |
| CITIGROUP INC | $370,449 | 37,917 | 0.17% | Shares |
| Nuveen, LLC | $369,971 | 37,868 | 0.17% | Shares |
| MILLENNIUM MANAGEMENT LLC | $351,720 | 36,000 | 0.16% | Put option |
| Engineers Gate Manager LP | $331,848 | 33,966 | 0.15% | Shares |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $326,000 | 33,333 | 0.15% | Shares |
| JANE STREET GROUP, LLC | $324,100 | 33,173 | 0.15% | Shares |
| TORONTO DOMINION BANK | $302,186 | 30,930 | 0.14% | Shares |
| SILVERBACK ASSET MANAGEMENT LLC | $293,100 | 30,000 | 0.14% | Shares |
| Baird Financial Group, Inc. | $291,058 | 29,791 | 0.14% | Shares |
| JANE STREET GROUP, LLC | $286,261 | 29,300 | 0.13% | Call option |
| ExodusPoint Capital Management, LP | $259,706 | 26,582 | 0.12% | Shares |
| China Universal Asset Management Co., Ltd. | $244,250 | 25,000 | 0.11% | Shares |
| SIMPLEX TRADING, LLC | $235,320 | 24,086 | 0.11% | Shares |
| JANE STREET GROUP, LLC | $232,526 | 23,800 | 0.11% | Put option |
| RHUMBLINE ADVISERS | $229,266 | 23,467 | 0.11% | Shares |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $227,299 | 23,265 | 0.11% | Shares |
| Velan Capital Investment Management LP | $195,400 | 20,000 | 0.09% | Shares |
| DEUTSCHE BANK AG\ | $189,782 | 19,425 | 0.09% | Shares |
| WELLS FARGO & COMPANY/MN | $165,142 | 16,903 | 0.08% | Shares |
| SEI INVESTMENTS CO | $147,361 | 15,083 | 0.07% | Shares |
| HSBC HOLDINGS PLC | $137,363 | 13,750 | 0.06% | Shares |
| CITADEL ADVISORS LLC | $133,849 | 13,700 | 0.06% | Put option |
| Headlands Technologies LLC | $118,344 | 12,113 | 0.05% | Shares |
| MetLife Investment Management, LLC | $117,406 | 12,017 | 0.05% | Shares |
| Y-Intercept (Hong Kong) Ltd | $101,364 | 10,375 | 0.05% | Shares |
| Quadrature Capital Ltd | $100,592 | 10,296 | 0.05% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $89,601 | 9,171 | 0.04% | Shares |
| FMR LLC | $87,305 | 8,936 | 0.04% | Shares |
| Vanguard Global Advisers, LLC | $80,182 | 8,207 | 0.04% | Shares |
| Police & Firemen's Retirement System of New Jersey | $57,389 | 5,874 | 0.03% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $54,712 | 5,600 | 0.03% | Shares |
| TD Waterhouse Canada Inc. | $54,502 | 5,707 | 0.03% | Shares |
| Legal & General Group Plc | $18,905 | 1,935 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $17,664 | 1,808 | 0.01% | Shares |
| Russell Investments Group, Ltd. | $15,553 | 1,592 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $12,300 | 1,259 | 0.01% | Shares |
| T. Rowe Price Investment Management, Inc. | $7,683 | 786,309 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $3,927 | 402 | 0.00% | Shares |
| Sterling Capital Management LLC | $3,439 | 352 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $2,916 | 298,997 | 0.00% | Shares |
| HARBOUR INVESTMENTS, INC. | $2,784 | 285 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2,677 | 274 | 0.00% | Shares |
| Quent Capital, LLC | $1,622 | 166 | 0.00% | Shares |
| MB, LEVIS & ASSOCIATES, LLC | $977 | 100 | 0.00% | Shares |
| C WorldWide Group Holding A/S | $977 | 100,000 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $655 | 67 | 0.00% | Shares |
| Activest Wealth Management | $645 | 66 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $266 | 27,225 | 0.00% | Shares |
| Allworth Financial LP | $255 | 26 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $137 | 14 | 0.00% | Shares |
| Virtu Financial LLC | $105 | 10,728 | 0.00% | Shares |
| CIBC Private Wealth Group LLC | $20 | 3 | 0.00% | Shares |
| West Branch Capital LLC | $17 | 3 | 0.00% | Shares |
| PlanVest Financial, Inc | $10 | 1 | 0.00% | Shares |