Avidity Partners Management LP
CIK 1791827 · View on SEC EDGAR ↗
- Portfolio value
- $624.4M
- Positions
- 45
- As of
- June 30, 2026
#3,287 of 9,443 by 13F value · top 34.8%
Portfolio value QoQ: +23.6% 13F does not disclose cash
- Top 10 holdings weight
- 81.94%
- Top 25 holdings weight
- 95.70%
- Positions above 1%
- 15
- Effective number of positions
- 6.4
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 8.62% Est. buys $83,155,192 · sells $48,683,630
Median holding: 2.0 quarters Tracked Q4 2024–Q2 2026 · 29.8% still held
- New positions
- 9
- Increased
- 12
- Decreased
- 6
- Closed
- 16
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- High-conviction bets The holdings this manager is most concentrated in.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
- Related The person behind this filer, where we can match one.
Performance vs S&P 500
Annualized: +76.3% · S&P 500: +18.0%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 96.8% · Options excluded: 1.7%
Sector breakdown
Healthcare
88.7%
Consumer products
0.2%
Consumer Discretionary
0.1%
Other/Unmapped
11.0%
Full portfolio 45 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| DNTH Dianthus Therapeutics, Inc. - Common Stock | $205,115,856 | 32.85% | 2,104,184 | $28,532,735 | |||
| CGON CG Oncology, Inc. - Common stock | $99,395,255 | 15.92% | 1,398,948 | $12,159,254 | Up ×1 | ||
| ORKA Oruka Therapeutics, Inc. - Common Stock | $72,369,552 | 11.59% | 760,424 | $35,070,755 | |||
| JBIO Jade Biosciences, Inc. - Common Stock | $37,789,732 | 6.05% | 1,700,708 | $18,109,785 | Up ×1 | ||
| ELVN Enliven Therapeutics, Inc. - Common Stock | $27,912,500 | 4.47% | 550,000 | $12,232,500 | Up ×2 | ||
| CATX | $21,482,997 | 3.44% | 6,299,999 | $-3,745,499 | Up ×4 | ||
| AKTS Aktis Oncology, Inc. - Common stock | $15,605,766 | 2.50% | 484,200 | $7,223,120 | Up ×1 | ||
| PVLA Palvella Therapeutics, Inc. - Common Stock | $10,697,400 | 1.71% | 70,000 | $1,971,900 | |||
| Unknown issuer (CUSIP: 60705V103) | $10,696,979 | 1.71% | 798,282 | Up ×1 | |||
| RGEN Repligen Corporation - Common Stock | $10,615,032 | 1.70% | 77,800 | $1,448,636 | |||
| Unknown issuer (CUSIP: 4525EP200) | $10,296,993 | 1.65% | 669,941 | Up ×1 | |||
| SENS Senseonics Holdings, Inc. - Common Stock | $9,088,000 | 1.46% | 1,600,000 | Up ×1 | |||
| KPTI Karyopharm Therapeutics Inc. - Common Stock | $9,032,238 | 1.45% | 924,487 | $6,449,201 | Up ×2 | ||
| TEVA Teva Pharmaceutical Industries Limited American Depositary Shares | $6,776,000 | 1.09% | 200,000 | $-6,781,012 | Down ×1 | ||
| DXCM DexCom, Inc. - Common Stock | $6,735,000 | 1.08% | 100,000 | $1,083,000 | Up ×1 | ||
| TEM Tempus AI, Inc. - Class A Common Stock | $6,082,650 | 0.97% | 105,000 | $4,952,150 | Up ×1 | ||
| MDT Medtronic plc. Ordinary Shares | $5,476,100 | 0.88% | 70,000 | $-3,188,900 | Down ×3 | ||
| VIR Vir Biotechnology, Inc. - Common Stock | $5,291,667 | 0.85% | 519,300 | $-3,220,333 | Down ×1 | ||
| GPCR Structure Therapeutics Inc. - American Depositary Shares | $5,259,660 | 0.84% | 98,000 | $3,813,660 | Up ×1 | ||
| EHC Encompass Health Corporation Common Stock | $4,245,360 | 0.68% | 42,000 | $182,700 | |||
| TENX Tenax Therapeutics, Inc. - Common Stock | $3,869,340 | 0.62% | 265,934 | $416,555 | Up ×1 | ||
| NVCT Nuvectis Pharma, Inc. - Common Stock | $3,678,000 | 0.59% | 200,000 | Up ×1 | |||
| PODD Insulet Corporation - Common Stock | $3,654,000 | 0.59% | 24,000 | $1,932,600 | Up ×1 | ||
| BSX Boston Scientific Corporation Common Stock | $3,414,400 | 0.55% | 80,000 | $-350,600 | Up ×1 | ||
| MSLE Satellos Bioscience Inc. - Common Stock | $3,014,904 | 0.48% | 387,769 | $831,765 | |||
| Unknown issuer (CUSIP: 010911105) | $2,979,900 | 0.48% | 110,000 | Up ×1 | |||
| CNTX Context Therapeutics Inc. - Common Stock | $2,768,540 | 0.44% | 4,998,267 | $-10,326,920 | |||
| GILD Gilead Sciences, Inc. - Common Stock | $2,526,800 | 0.40% | 20,000 | $-260,600 | |||
| CRL Charles River Laboratories International, Inc. Common Stock | $2,267,900 | 0.36% | 10,000 | $598,200 | |||
| PHAT Phathom Pharmaceuticals, Inc. - Common Stock | $2,170,000 | 0.35% | 200,000 | $-600,723 | Down ×1 | ||
| Unknown issuer (CUSIP: 05348Y105) | $1,975,200 | 0.32% | 60,000 | Up ×1 | |||
| Unknown issuer (CUSIP: 482931102) | $1,762,400 | 0.28% | 80,000 | Up ×1 | |||
| GMAB Genmab A/S - American Depositary Shares | $1,373,500 | 0.22% | 50,000 | $32,000 | |||
| NTLA Intellia Therapeutics, Inc. - Common Stock | $1,269,000 | 0.20% | 75,000 | $307,500 | |||
| CRVS Corvus Pharmaceuticals, Inc. - Common Stock | $1,195,200 | 0.19% | 80,000 | $-487,250 | Down ×1 | ||
| ODD ODDITY Tech Ltd. - Class A Ordinary Shares | $1,059,100 | 0.17% | 70,000 | $122,500 | |||
| Unknown issuer (CUSIP: 811292309) | $1,059,038 | 0.17% | 260,206 | Up ×1 | |||
| EVMN Evommune, Inc. Common Stock | $996,750 | 0.16% | 75,000 | Up ×1 | |||
| ABT Abbott Laboratories Common Stock | $907,400 | 0.15% | 10,000 | $-500 | |||
| BBIO BridgeBio Pharma, Inc. - Common Stock | $744,800 | 0.12% | 10,000 | $33,700 | |||
| PTON Peloton Interactive, Inc. - Common Stock | $591,000 | 0.09% | 100,000 | $-267,000 | Down ×1 | ||
| LEGN Legend Biotech Corporation - American Depositary Shares | $433,200 | 0.07% | 15,000 | $80,400 | |||
| BBOT BridgeBio Oncology Therapeutics, Inc. - Common Stock | $334,160 | 0.05% | 43,853 | $-58,324 | |||
| SVRA Savara, Inc. - Common Stock | $308,000 | 0.05% | 50,000 | $46,000 | |||
| TRVI Trevi Therapeutics, Inc. - Common Stock | $124,209 | 0.02% | 6,660 | $44,755 | |||
| No matches | |||||||
Conviction holdings
Positions increased for 3+ consecutive quarters.
Share counts are as reported in 13F filings (not split-adjusted)
| Security | Value | % of portfolio | Streak |
|---|---|---|---|
| CATX | $21,482,997 | 3.44% | up ×4 |
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| Unknown issuer (CUSIP: 60705V103) | $10,696,979 | 798,282 | 1.71% |
| Unknown issuer (CUSIP: 4525EP200) | $10,296,993 | 669,941 | 1.65% |
| SENS | $9,088,000 | 1,600,000 | 1.46% |
| NVCT | $3,678,000 | 200,000 | 0.59% |
| Unknown issuer (CUSIP: 010911105) | $2,979,900 | 110,000 | 0.48% |
| Unknown issuer (CUSIP: 05348Y105) | $1,975,200 | 60,000 | 0.32% |
| Unknown issuer (CUSIP: 482931102) | $1,762,400 | 80,000 | 0.28% |
| Unknown issuer (CUSIP: 811292309) | $1,059,038 | 260,206 | 0.17% |
| EVMN | $996,750 | 75,000 | 0.16% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| ORKA | Price move only | +0 | +$35.1M |
| DNTH | Price move only | +0 | +$28.5M |
| JBIO | Bought more | +300K | +$18.1M |
| ELVN | Bought more | +150K | +$12.2M |
| CGON | Bought more | +110K | +$12.2M |
| CNTX | Price move only | +0 | -$10.3M |
| AKTS | Bought more | +16K | +$7.2M |
| TEVA | Trimmed | -250K | -$6.8M |
| KPTI | Bought more | +461K | +$6.4M |
| GPCR | Bought more | +68K | +$3.8M |
1 position hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| ISRG | March 31, 2025 | 64,800 | $33,823,008 | -20.3% |
| ACHC | March 31, 2025 | 658,000 | $26,089,700 | -8.6% |
| KYMR | March 31, 2025 | 500,000 | $20,115,000 | 354.3% |
| THC | Sept. 30, 2025 | 106,000 | $18,656,000 | 35.0% |
| DXCM | Sept. 30, 2025 | 210,500 | $18,374,545 | 35.3% |
| HNGE | Sept. 30, 2025 | 322,344 | $16,681,302 | 80.6% |
| REGN | June 30, 2025 | 25,400 | $16,109,442 | 59.0% |
| ISRG | Sept. 30, 2025 | 27,100 | $14,726,411 | -11.7% |
| ILMN | March 31, 2025 | 109,700 | $14,659,211 | 165.7% |
| ABBV | March 31, 2025 | 80,700 | $14,340,390 | 26.6% |
| RCKT | March 31, 2025 | 1,053,300 | $13,239,981 | -47.2% |
| GKOS | June 30, 2025 | 134,000 | $13,188,280 | 84.5% |
| BMY | March 31, 2025 | 215,000 | $12,160,400 | 9.5% |
| TMDX | March 31, 2025 | 192,400 | $11,996,140 | 39.3% |
| BMY | Dec. 31, 2025 | 257,600 | $11,617,760 | 23.8% |
| SGRY | March 31, 2025 | 514,200 | $10,885,614 | -42.1% |
| ORIC | March 31, 2025 | 1,265,200 | $10,210,164 | 156.5% |
| JAZZ | June 30, 2025 | 80,000 | $9,932,000 | 136.8% |
| AXSM | Sept. 30, 2025 | 94,500 | $9,864,855 | 78.1% |
| NBIX | June 30, 2025 | 85,700 | $9,478,420 | 23.2% |
| INCY | March 31, 2025 | 129,600 | $8,951,472 | 111.6% |
| ASND | March 31, 2025 | 62,000 | $8,535,540 | 66.4% |
| RVMD | Sept. 30, 2025 | 228,600 | $8,410,194 | 349.8% |
| ALNY | March 31, 2026 | 21,000 | $8,350,650 | -27.8% |
| ITCI | March 31, 2025 | 97,000 | $8,101,440 | No longer tracked |
| MCK | March 31, 2026 | 9,520 | $7,809,161 | -1.7% |
| XBI | June 30, 2025 | 94,000 | $7,623,400 | No longer tracked |
| CNTA | June 30, 2025 | 529,000 | $7,607,020 | No longer tracked |
| IMUX | June 30, 2026 | 6,699,411 | $7,436,346 | 7.7% |
| MTSR | Dec. 31, 2025 | 140,500 | $7,352,365 | No longer tracked |
| AVTR | June 30, 2025 | 453,000 | $7,343,130 | 5.6% |
| IDYA | June 30, 2025 | 445,000 | $7,289,100 | 81.4% |
| OMDA | Sept. 30, 2025 | 390,600 | $7,147,980 | 11.3% |
| JANX | June 30, 2025 | 258,000 | $6,966,000 | -24.7% |
| HUM | Sept. 30, 2025 | 27,600 | $6,747,648 | 47.1% |
| OGN | Sept. 30, 2025 | 640,000 | $6,195,200 | 28.6% |
| UNH | Dec. 31, 2025 | 17,800 | $6,146,340 | 18.8% |
| BPMC | June 30, 2025 | 68,500 | $6,062,935 | No longer tracked |
| BBIO | Sept. 30, 2025 | 140,000 | $6,045,200 | 60.3% |
| ARVN | Dec. 31, 2025 | 698,363 | $5,950,053 | -20.2% |
| HUM | June 30, 2026 | 25,000 | $5,911,000 | -3.6% |
| MDGL | Sept. 30, 2025 | 19,000 | $5,750,160 | 16.9% |
| A | March 31, 2026 | 41,500 | $5,646,905 | 36.7% |
| RARE | Sept. 30, 2025 | 154,000 | $5,599,440 | -11.7% |
| UTHR | June 30, 2025 | 16,800 | $5,178,936 | 82.5% |
| PFE | March 31, 2026 | 203,600 | $5,069,640 | -0.9% |
| JNJ | Dec. 31, 2025 | 26,800 | $4,969,256 | 31.4% |
| BRKR | June 30, 2025 | 115,000 | $4,800,100 | 43.5% |
| SNDX | Sept. 30, 2025 | 490,000 | $4,588,850 | 32.2% |
| ABBV | Dec. 31, 2025 | 19,800 | $4,584,492 | 16.1% |
| CARL | Dec. 31, 2025 | 321,912 | $4,310,402 | 24.9% |
| ARQT | Dec. 31, 2025 | 214,400 | $4,041,440 | -11.6% |
| EXAS | Dec. 31, 2025 | 73,600 | $4,026,656 | No longer tracked |
| DHR | March 31, 2026 | 17,000 | $3,891,640 | 13.2% |
| TMO | March 31, 2026 | 6,700 | $3,882,315 | 26.1% |
| DOCS | Sept. 30, 2025 | 60,000 | $3,680,400 | -64.8% |
| BHVN | June 30, 2025 | 145,000 | $3,485,800 | -1.5% |
| NVO | March 31, 2026 | 67,300 | $3,424,224 | 26.6% |
| KROS | March 31, 2025 | 210,000 | $3,324,300 | 5.7% |
| VRNA | Sept. 30, 2025 | 33,800 | $3,196,804 | No longer tracked |
| CI | March 31, 2026 | 11,600 | $3,192,668 | 4.3% |
| COR | March 31, 2026 | 9,400 | $3,174,850 | 0.5% |
| INSM | March 31, 2026 | 17,700 | $3,080,508 | -21.5% |
| WAT | March 31, 2026 | 8,100 | $3,076,623 | 39.3% |
| QURE | Sept. 30, 2025 | 207,000 | $2,885,580 | -17.9% |
| ASND | Dec. 31, 2025 | 14,500 | $2,882,745 | 21.6% |
| APGE | Sept. 30, 2025 | 65,000 | $2,822,950 | 239.1% |
| ACAD | June 30, 2025 | 169,000 | $2,807,090 | 38.1% |
| BEAM | Dec. 31, 2025 | 112,000 | $2,718,240 | -0.6% |
| RPRX | June 30, 2025 | 87,000 | $2,708,310 | 71.6% |
| SLNO | Sept. 30, 2025 | 32,000 | $2,680,960 | No longer tracked |
| CAH | Sept. 30, 2025 | 15,000 | $2,520,000 | 47.7% |
| SPRY | Sept. 30, 2025 | 140,000 | $2,443,000 | -39.0% |
| ACHC | March 31, 2026 | 169,000 | $2,398,110 | 18.5% |
| ITGR | March 31, 2026 | 29,800 | $2,337,214 | 42.5% |
| KZR | Sept. 30, 2025 | 502,600 | $2,301,908 | No longer tracked |
| CNC | June 30, 2026 | 70,000 | $2,291,800 | -0.4% |
| CAPR | June 30, 2025 | 239,000 | $2,268,110 | -24.6% |
| DYN | March 31, 2025 | 96,000 | $2,261,760 | 148.8% |
| COGT | March 31, 2025 | 287,104 | $2,239,411 | 505.3% |
| LXEO | June 30, 2025 | 645,000 | $2,238,150 | 29.6% |
| VERA | June 30, 2025 | 91,000 | $2,185,820 | 34.0% |
| WVE | Dec. 31, 2025 | 297,500 | $2,177,700 | -68.6% |
| NTLA | Sept. 30, 2025 | 232,000 | $2,176,160 | -26.6% |
| XENE | Dec. 31, 2025 | 53,400 | $2,144,010 | 37.6% |
| AKRO | Dec. 31, 2025 | 40,500 | $1,922,940 | No longer tracked |
| SCYX | June 30, 2026 | 2,081,660 | $1,908,674 | 29.2% |
| RGNX | June 30, 2025 | 260,000 | $1,859,000 | 38.9% |
| MLTX | Sept. 30, 2025 | 39,000 | $1,840,800 | 128.2% |
| IONS | June 30, 2025 | 60,000 | $1,810,200 | 50.5% |
| MIRM | June 30, 2025 | 40,000 | $1,802,000 | 96.6% |
| NTRA | June 30, 2026 | 9,000 | $1,799,910 | 21.0% |
| ICLR | June 30, 2026 | 16,000 | $1,770,560 | 1.8% |
| KVUE | June 30, 2026 | 100,000 | $1,724,000 | 0.0% |
| NMRA | March 31, 2025 | 150,000 | $1,590,000 | 59.0% |
| HIMS | June 30, 2026 | 75,000 | $1,557,000 | -5.1% |
| HQY | March 31, 2026 | 16,900 | $1,548,209 | 26.3% |
| RVMD | June 30, 2026 | 15,000 | $1,458,750 | 12.2% |
| NAMS | June 30, 2025 | 68,000 | $1,391,960 | 54.4% |
| KPTIXXXX | March 31, 2025 | 2,018,500 | $1,365,112 | No longer tracked |
| AGL | June 30, 2025 | 305,100 | $1,321,083 | 59.0% |
| CORT | June 30, 2026 | 30,000 | $1,209,300 | 36.7% |
| ABVX | June 30, 2026 | 10,000 | $1,113,500 | -11.7% |
| UNH | June 30, 2026 | 3,800 | $1,028,242 | -5.6% |
| IQV | March 31, 2026 | 4,400 | $991,804 | 49.3% |
| MLTX | June 30, 2026 | 50,000 | $932,000 | -15.9% |
| PCVX | June 30, 2025 | 23,000 | $868,480 | 89.4% |
| AVR | June 30, 2026 | 150,000 | $832,500 | -1.6% |
| BLUE | March 31, 2025 | 81,555 | $680,169 | No longer tracked |
| IMRX | Dec. 31, 2025 | 90,900 | $636,300 | -20.1% |
| ABUS | June 30, 2026 | 125,000 | $562,500 | 3.1% |
| ALT | Sept. 30, 2025 | 105,000 | $406,350 | -19.9% |
| ACAD | June 30, 2026 | 12,967 | $288,645 | 17.7% |
| HYPR | June 30, 2025 | 222,174 | $159,143 | 27.1% |
| RVPH | Sept. 30, 2025 | 138,000 | $52,592 | No longer tracked |