MAZE Maze Therapeutics, Inc. - Common Stock

NASDAQ · Pharmaceuticals · View on SEC EDGAR ↗
$27.99
Price · Aug 18, 2026
Fundamentals as of Aug 11, 2026
52W Range
$13–$54
37% of range
Analyst Rating
BUY
18 analysts
Price Target
$63
+123% upside
P/E (TTM)
-9.3
ROE
-598.9%
Net Profit Margin
—

MAZE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$27.99
Market Cap
$1.39B
P/E (TTM)
-9.3
EPS (TTM)
$-3.05
Revenue (TTM)
$168M
Div Yield
—
ROE
-598.9%
Debt/Equity
—
52W Range
$13 – $54

MAZE Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $168M
2024-12-31 → 2024-12-31
EPS $-3.05
2-point trend, -344.0%
2024-12-31 → 2025-12-31
Free Cash Flow $-113M
2025-12-31 → 2025-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
MAZE
Peer Median
P/E (TTM)
-9.3
15.8
P/B
3.9
3.3
Price / FCF
-12.3
—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
MAZE
Peer Median
ROA
-41.1%
-2.9%
ROE
-598.9%
-6.8%
ROIC
-40.3%
—

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
MAZE
Peer Median
Current Ratio
15.5
5.3
Quick Ratio
15.2
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
MAZE
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
MAZE
Peer Median
EPS (Diluted)
2-point trend, -344.0%
$-3.05
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
MAZE
Peer Median

MAZE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 18 analysts
  • Strong Buy 7 38.9%
  • Buy 10 55.6%
  • Hold 1 5.6%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

11 analysts · 2026-08-15
Median target $55.00 +96.5%
Mean target $62.55 +123.4%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-3.1%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.45 $-0.56 0.11%
Dec. 31, 2025 $-0.65 $-0.73 0.08%
Sept. 30, 2025 $-0.66 $-0.72 0.06%
June 30, 2025 $-0.77 $-0.87 0.10%
March 31, 2025 $-1.15 $-0.77 -0.38%
Dec. 31, 2024 $-18.32 $0.46 -18.8%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
MAZE $2.04B -13.6 — — -598.9% —
TRLV — — -0.45% -10.3% -10.4% 60.2%
ANIP $1.78B 23.8 43.8% 8.9% 16.6% —
ETON $457M — 104.9% -5.8% -18.4% 53.5%
AVLN — — — — — —
INVA — 6.1 14.7% — — —
LBRX $563M -7.1 — — -25.5% —
HROW $1.82B -350.0 36.4% -1.9% -8.4% 75.0%
XERS $1.30B — 43.7% 0.19% -19.7% —
PAHC — 21.5 27.4% 3.7% 17.8% 30.9%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 13
Annual Income Statement data for MAZE
Metric Trend 20252024
Revenue · $168M
R&D Expense 2-point trend, +29.9% $108M $83M
SG&A Expense 2-point trend, +30.4% $34M $26M
Operating Expenses 2-point trend, +30.0% $143M $110M
Operating Income 2-point trend, -348.1% $-143M $58M
Pretax Income 2-point trend, -345.5% $-131M $53M
Income Tax 2-point trend, -100.0% $0 $1M
Net Income 2-point trend, -351.0% $-131M $52M
EPS (Basic) 2-point trend, -314.8% $-3.05 $1.42
EPS (Diluted) 2-point trend, -344.0% $-3.05 $1.25
Shares (Basic) 2-point trend, +1693.6% 42,976,024 2,396,094
Shares (Diluted) 2-point trend, +1474.0% 42,976,024 2,730,299
EBITDA $-143M ·
Balance Sheet 20
Annual Balance Sheet data for MAZE
Metric Trend 20252024
Cash & Equivalents 2-point trend, -3.8% $189M $197M
Short-term Investments $153M ·
Prepaid Expense 2-point trend, +60.5% $8M $5M
Current Assets 2-point trend, +73.4% $350M $202M
PP&E (Net) 2-point trend, -24.4% $5M $7M
PP&E (Gross) 2-point trend, +3.1% $24M $24M
Accum. Depreciation 2-point trend, +13.9% $19M $17M
Other Non-current Assets 2-point trend, -61.2% $3M $8M
Total Assets 2-point trend, +65.1% $397M $241M
Accounts Payable 2-point trend, -7.5% $2M $2M
Current Liabilities 2-point trend, +9.1% $23M $21M
Capital Leases 2-point trend, -15.8% $19M $22M
Other Non-current Liabilities 2-point trend, +12.9% $1M $969.0K
Total Liabilities 2-point trend, -3.4% $42M $44M
Common Stock 2-point trend, +2350.0% $49.0K $2.0K
Paid-in Capital 2-point trend, +1687.3% $844M $47M
Retained Earnings 2-point trend, -36.6% $-490M $-358M
Stockholders' Equity 2-point trend, +214.1% $355M $-311M
Liabilities + Equity 2-point trend, +65.1% $397M $241M
Shares Outstanding 2-point trend, +1916.3% 49,335,551 2,446,864
Cash Flow 7
Annual Cash Flow data for MAZE
Metric Trend 20252024
Stock-based Comp 2-point trend, +70.0% $16M $10M
Operating Cash Flow 2-point trend, -247.4% $-112M $76M
CapEx 2-point trend, -30.8% $794.0K $1M
Investing Cash Flow 2-point trend, -14805.1% $-171M $-1M
Financing Cash Flow 2-point trend, +196.5% $275M $93M
Taxes Paid · $1M
Free Cash Flow $-113M ·
Profitability 3
Annual Profitability data for MAZE
Metric Trend 20252024
ROA -41.1% ·
ROE -598.9% ·
ROIC -40.3% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for MAZE
Metric Trend 20252024
Current Ratio 15.5 ·
Quick Ratio 15.2 ·
Per Share 4
Annual Per Share data for MAZE
Metric Trend 20252024
Book Value / Share $7.19 ·
Cash Flow / Share $-2.60 ·
Cash / Share $3.84 ·
EPS (TTM) 2-point trend, -344.0% $-3.05 $1.25
Valuation (TTM) 9
Annual Valuation (TTM) data for MAZE
Metric Trend 20252024
Revenue TTM · $168M
Net Income TTM 2-point trend, -351.0% $-131M $52M
Market Cap $2.04B ·
P/E -13.6 ·
P/B 5.8 ·
P / Tangible Book 5.8 ·
P / Cash Flow -18.3 ·
P / FCF -18.1 ·
Earnings Yield -7.4% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-31
Revenue —$168M
Net Income $-131M$52M
Diluted EPS $-3.05$1.25
Balance Sheet
2025-12-312024-12-31
Current Ratio 15.5—
Quick Ratio 15.2—
Cash Flow
2025-12-312024-12-31
Free Cash Flow $-113M—

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Institutional owners (13F) 174 filers · $1.5B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
46 (-9 vs prior Q) 41 (+16 vs prior Q) 60 (+8 vs prior Q) 39 (+1 vs prior Q) +4.1M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Frazier Life Sciences Management, L.P. $150,182,184 5,032,915 10.06% Shares
TRV GP IV, LLC $133,502,907 4,473,958 8.94% Shares
ARCH Venture Management, LLC $122,983,582 4,120,053 8.24% Shares
Deep Track Capital, LP $111,379,859 3,732,569 7.46% Shares
JANUS HENDERSON GROUP PLC $85,280,271 2,858,876 5.71% Shares
Logos Global Management LP $57,740,400 1,935,000 3.87% Shares
VANGUARD CAPITAL MANAGEMENT LLC $53,062,144 1,778,222 3.55% Shares
a16z Capital Management, L.L.C. $50,794,394 1,702,225 3.40% Shares
Venrock Adviser, LLC $47,804,695 1,602,034 3.20% Shares
Alphabet Inc. $41,435,317 1,388,583 2.78% Shares
BRAIDWELL LP $34,018,794 1,140,040 2.28% Shares
FARALLON CAPITAL MANAGEMENT, L.L.C. $33,057,170 1,107,814 2.21% Shares
General Catalyst Group Management, LLC $30,911,554 1,035,910 2.07% Shares
STATE STREET CORP $29,766,385 997,533 1.99% Shares
Driehaus Capital Management LLC $28,493,798 954,886 1.91% Shares
TRV GP V, LLC $28,371,872 950,800 1.90% Shares
FMR LLC $27,297,662 914,801 1.83% Shares
MARSHALL WACE, LLP $27,290,827 914,572 1.83% Shares
Casdin Capital, LLC $25,180,693 843,857 1.69% Shares
ArrowMark Colorado Holdings LLC $22,898,709 767,383 1.53% Shares
GEODE CAPITAL MANAGEMENT, LLC $22,104,385 740,626 1.48% Shares
Woodline Partners LP $21,968,685 736,216 1.47% Shares
JPMORGAN CHASE & CO $20,547,602 707,191 1.38% Shares
CITADEL ADVISORS LLC $18,763,392 628,800 1.26% Shares
SPHERA FUNDS MANAGEMENT LTD. $12,460,110 417,564 0.83% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $11,730,313 393,107 0.79% Shares
Aberdeen Group plc $11,451,786 383,773 0.77% Shares
Ikarian Capital, LLC $11,309,331 378,999 0.76% Shares
HHLR ADVISORS, LTD. $10,922,276 366,028 0.73% Shares
ADAR1 Capital Management, LLC $10,123,996 339,276 0.68% Shares
Squadron Capital Management LLC $9,996,400 335,000 0.67% Shares
BANK OF AMERICA CORP /DE/ $9,307,902 311,927 0.62% Shares
Candriam S.C.A. $8,166,266 273,932 0.55% Shares
Hudson Bay Capital Management LP $8,056,800 270,000 0.54% Shares
GOLDMAN SACHS GROUP INC $7,896,410 264,625 0.53% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $7,775,289 260,566 0.52% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $7,400,320 248,000 0.50% Shares
Mass General Brigham, Inc $7,161,421 239,994 0.48% Shares
AMERIPRISE FINANCIAL INC $6,786,363 227,425 0.45% Shares
VANGUARD FIDUCIARY TRUST CO $6,562,950 219,938 0.44% Shares
RTW INVESTMENTS, LP $6,326,080 212,000 0.42% Shares
VANGUARD GROUP INC $6,060,795 146,290 0.41% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $5,796,288 199,872 0.39% Shares
TWO SIGMA INVESTMENTS, LP $5,757,688 192,952 0.39% Shares
BOOTHBAY FUND MANAGEMENT, LLC $5,635,493 188,857 0.38% Shares
ExodusPoint Capital Management, LP $5,468,598 183,264 0.37% Shares
SummitTX Capital, L.P. $5,260,523 176,291 0.35% Shares
HighVista Strategies LLC $4,075,308 136,572 0.27% Shares
Qube Research & Technologies Ltd $3,910,323 131,043 0.26% Shares
Walleye Capital LLC $3,819,699 128,006 0.26% Shares
Exome Asset Management LLC $3,422,409 114,692 0.23% Shares
Ensign Peak Advisors, Inc $3,033,057 101,644 0.20% Shares
Alyeska Investment Group, L.P. $2,984,000 100,000 0.20% Shares
ALGERT GLOBAL LLC $2,785,773 93,357 0.19% Shares
BlackRock, Inc. $2,602,794 87,225 0.17% Shares
UBS Group AG $2,523,181 84,557 0.17% Shares
Trexquant Investment LP $2,436,973 81,668 0.16% Shares
FRANKLIN RESOURCES INC $2,321,104 77,785 0.16% Shares
BNP PARIBAS FINANCIAL MARKETS $2,305,170 77,251 0.15% Shares
XTX Topco Ltd $2,247,459 75,317 0.15% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $2,219,617 74,384 0.15% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $1,953,565 65,468 0.13% Shares
DAFNA Capital Management LLC $1,939,600 65,000 0.13% Shares
ALPS ADVISORS INC $1,670,145 55,970 0.11% Shares
Jump Financial, LLC $1,406,329 47,129 0.09% Shares
Swiss National Bank $1,405,464 47,100 0.09% Shares
FIRST TRUST ADVISORS LP $1,379,413 46,227 0.09% Shares
Propel Bio Management, LLC $1,306,932 43,798 0.09% Shares
RHUMBLINE ADVISERS $1,279,322 42,873 0.09% Shares
ALLIANCEBERNSTEIN L.P. $1,128,330 37,800 0.08% Shares
Bank of New York Mellon Corp $979,975 32,841 0.07% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $969,800 32,500 0.06% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $954,880 32,000 0.06% Call option
WELLS FARGO & COMPANY/MN $947,330 31,747 0.06% Shares
Quadrature Capital Ltd $896,602 30,047 0.06% Shares
CITIGROUP INC $842,353 28,229 0.06% Shares
AQR CAPITAL MANAGEMENT LLC $792,819 26,569 0.05% Shares
WELLINGTON MANAGEMENT GROUP LLP $782,256 26,215 0.05% Shares
STATE OF WISCONSIN INVESTMENT BOARD $711,386 23,840 0.05% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $706,522 23,677 0.05% Shares
TD Asset Management Inc $661,672 22,174 0.04% Shares
NOMURA HOLDINGS INC $626,640 21,000 0.04% Call option
NOMURA HOLDINGS INC $626,640 21,000 0.04% Put option
MetLife Investment Management, LLC $623,626 20,899 0.04% Shares
BARCLAYS PLC $614,882 20,606 0.04% Shares
TWO SIGMA ADVISERS, LP $613,164 14,800 0.04% Shares
Balyasny Asset Management L.P. $602,470 20,190 0.04% Shares
Squarepoint Ops LLC $579,911 19,434 0.04% Shares
Verition Fund Management LLC $543,118 18,201 0.04% Shares
VANGUARD ASSET MANAGEMENT, Ltd $490,450 16,436 0.03% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $489,436 16,402 0.03% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $484,840 16,248 0.03% Shares
MORGAN STANLEY $463,893 15,546 0.03% Shares
AXQ CAPITAL, LP $453,359 15,193 0.03% Shares
Y-Intercept (Hong Kong) Ltd $428,801 14,370 0.03% Shares
Invesco Ltd. $419,550 14,060 0.03% Shares
China Universal Asset Management Co., Ltd. $412,031 13,808 0.03% Shares
Virtus Investment Advisers, LLC $405,973 13,605 0.03% Shares
Verdad Advisers, LP $376,521 12,618 0.03% Shares
CITADEL ADVISORS LLC $375,984 12,600 0.03% Call option

Company insiders 11 insiders · 1 officers · 6 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Atul Dandekar CSBO July 29, 2026 M 26,250 0 4 $-612,761
Nancy C Andrews Director June 8, 2026 A — 0 0 $0
Herve Hoppenot Director June 8, 2026 A — 0 0 $0
Jonathan E Lim Director June 8, 2026 A — 0 0 $0
Daniel K Spiegelman Director June 8, 2026 A — 0 0 $0
Richard H Scheller Director June 8, 2026 A 0 0 1 $-464,043
Charles J Homcy Director June 8, 2026 A 31,113 0 0 $0
Harold Bernstein — Aug. 13, 2026 M 0 0 4 $-1,221,422
Sophie Kornowski — Aug. 13, 2026 A — 0 0 $0
Paula A Johnson — Aug. 13, 2026 A — 0 0 $0
Jason V Coloma — Aug. 3, 2026 S 255,263 0 11 $-2,841,393

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 39 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
SBIO · ALPS ETF Trust 0.81% 49,602 NS May 31, 2026 N-PORT
PILL · Direxion Shares ETF Trust 0.71% 3,421 NS April 30, 2026 N-PORT
BBC · ETFis Series Trust I 0.51% 7,102 NS April 30, 2026 N-PORT
IWC · iShares Trust 0.23% 120,190 SH Aug. 8, 2026 Daily
IHE · iShares Trust 0.18% 100,508 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.12% 79,727 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.11% 3,014 SH Aug. 8, 2026 Daily
FYC · First Trust Exchange-Traded AlphaDE… 0.10% 38,381 NS April 30, 2026 N-PORT
ESSC · Strategy Shares 0.10% 925 NS April 30, 2026 N-PORT
IBB · iShares Trust 0.08% 254,301 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.06% 1,778 NS May 31, 2026 N-PORT
IWO · iShares Trust 0.05% 269,368 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.05% 31,513 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.03% 901,580 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.03% 203,079 SH Aug. 8, 2026 Daily
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.03% 7,548 NS April 30, 2026 N-PORT
RSSL · Global X Funds 0.02% 11,444 NS April 30, 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0.02% 3,578 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.02% 1,244 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.01% 5,055 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.01% 1,283 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.01% 100,724 NS May 31, 2026 N-PORT
IWN · iShares Trust 0.01% 53,236 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.01% 974 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.01% 325,413 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.01% 5,162 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 70,669 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.01% 982 NS May 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.01% 6,267 SH Aug. 8, 2026 Daily
AVSU · AMERICAN CENTURY ETF TRUST 0.01% 1,092 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.01% 1,441 SH Aug. 8, 2026 Daily
ONEQ · Fidelity Commonwealth Trust 0.00% 14,208 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 887 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 25 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 46,279 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 5,789 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.00% 11,544 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 1,411,990 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 2,957 SH Aug. 8, 2026 Daily