SPRY ARS Pharmaceuticals, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$6.54
Price · Aug 19, 2026
Fundamentals as of Aug 13, 2026

About ARS Pharmaceuticals, Inc. - Common Stock Company overview from Wikipedia

SPRY Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$6.54
Market Cap
$649M
P/E (TTM)
-3.8
EPS (TTM)
$-1.74
Revenue (TTM)
$84M
Div Yield
ROE
-111.8%
Debt/Equity
52W Range
$5 – $15

SPRY Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $84M
5-point trend, +1430.7%
2021-12-31 2025-12-31
EPS $-1.74
5-point trend, -148.6%
2021-12-31 2025-12-31
Free Cash Flow $-171M
5-point trend, -151.3%
2021-12-31 2025-12-31
Margins -203.3%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SPRY
Peer Median
P/E (TTM)
5-point trend, +29.6%
-3.8
19.6
P/S (TTM)
5-point trend, -67.7%
7.7
24.9
P/B
5-point trend, +1258.7%
5.7
3.1
Price / FCF
5-point trend, -96.9%
-3.8

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SPRY
Peer Median
Operating Margin
5-point trend, +99.7%
-212.9%
Net Profit Margin
5-point trend, +99.8%
-203.3%
-298.0%
ROA
5-point trend, -105.4%
-50.5%
-56.6%
ROE
5-point trend, -303.4%
-111.8%
-70.8%
ROIC
2-point trend, -13432.8%
-157.0%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SPRY
Peer Median
Current Ratio
5-point trend, -58.6%
7.3
5.2
Quick Ratio
5-point trend, -59.5%
6.9

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SPRY
Peer Median
Revenue YoY
5-point trend, +1430.7%
-5.5%
Revenue CAGR 3Y
5-point trend, +1430.7%
300.1%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SPRY
Peer Median
EPS (Diluted)
5-point trend, -148.6%
$-1.74

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SPRY
Peer Median

SPRY Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 10 analysts
  • Strong Buy 5 50.0%
  • Buy 4 40.0%
  • Hold 1 10.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

4 analysts · 2026-08-14
Median target $27.00 +312.8%
Mean target $26.75 +309.0%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.03%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.63 $-0.50 -0.13%
March 31, 2026 $-0.61 $-0.54 -0.07%
Dec. 31, 2025 $-0.42 $-0.45 0.03%
Sept. 30, 2025 $-0.52 $-0.48 -0.04%
June 30, 2025 $-0.46 $-0.48 0.02%
March 31, 2025 $-0.35 $-0.35 0.00%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SPRY $1.16B -6.7 -5.5% -203.3% -111.8%
CBIO $327M -24.2 -86.7% -1419.6% -90.0%
ASMB $539M -61.8 153.5% -8.5% -5.5%
NVCT $194M -5.7 -149.9%
MDXG $1.00B 21.2 20.0% 11.6% 20.5% 82.6%
ALT $400M -3.6 105.0% -214861.0% -45.6%
PRME $626M -2.6 55.3% -4342.4% -221.4%
ARTV -1.3 -99.2%
EIKN
OVID $212M -4.0 1181.3% -240.1% -18.7%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for SPRY
Metric Trend 20252024202320222021
Revenue 5-point trend, +1430.7% $84M $89M $30.0K $1M $6M
Cost of Revenue · · $0 · ·
R&D Expense 5-point trend, -35.0% $13M $20M $20M $18M $20M
SG&A Expense 5-point trend, +4809.8% $230M $72M $47M $603.0K $5M
Operating Expenses 5-point trend, +956.6% $264M $92M $68M $37M $25M
Operating Income 5-point trend, -822.4% $-179M $-3M $-68M $-36M $-19M
Other Non-op 5-point trend, +1122.8% $8M $11M $13M $974.0K $-789.0K
Pretax Income 3-point trend, -215.2% $-171M $8M $-54M · ·
Income Tax 5-point trend, -80000.00 $-80.0K $288.0K $0 $0 $0
Net Income 5-point trend, -746.2% $-171M $8M $-54M $-35M $-20M
EPS (Basic) 5-point trend, -148.6% $-1.74 $0.08 $-0.57 $-0.87 $-0.70
EPS (Diluted) 5-point trend, -148.6% $-1.74 $0.08 $-0.57 $-0.87 $-0.70
Shares (Basic) 5-point trend, +241.4% 98,566,481 96,936,661 95,215,322 39,956,043 28,872,242
Shares (Diluted) 5-point trend, +241.4% 98,566,481 102,390,828 95,215,322 39,956,043 28,872,242
EBITDA 5-point trend, -100.3% $-179M $-3M $-68M $-35M $-90M
Balance Sheet 27
Annual Balance Sheet data for SPRY
Metric Trend 20252024202320222021
Cash & Equivalents 5-point trend, -31.2% $41M $51M $71M $211M $60M
Short-term Investments 5-point trend, +203669000.00 $204M $263M $157M $64M $0
Receivables 3-point trend, +25347000.00 $25M $8M $0 · ·
Inventory 3-point trend, +31422000.00 $31M $11M $0 · ·
Prepaid Expense 5-point trend, +828.6% $6M $7M $3M $3M $667.0K
Current Assets 5-point trend, +369.1% $285M $334M $232M $278M $61M
PP&E (Net) 5-point trend, +3323.6% $2M $1M $574.0K $329.0K $72.0K
PP&E (Gross) 3-point trend, +708.1% · · $695.0K $377.0K $86.0K
Accum. Depreciation 4-point trend, +1328.6% · $200.0K $121.0K $48.0K $14.0K
Intangibles 3-point trend, +14452000.00 $14M $7M $0 · ·
Other Non-current Assets · · · $0 ·
Total Assets 5-point trend, +433.2% $328M $351M $233M $281M $61M
Accounts Payable 5-point trend, +220.5% $6M $10M $759.0K $2M $2M
Accrued Liabilities · · · · $12M
Short-term Debt 2-point trend, -100.0% · · · $0 $3M
Current Liabilities 5-point trend, +378.1% $39M $23M $2M $5M $8M
Capital Leases 4-point trend, -100.0% · $0 $37.0K $251.0K $480.0K
Total Liabilities 5-point trend, +1179.6% $213M $94M $2M $9M $17M
Long-term Debt 2-point trend, +96374000.00 $96M $0 · · ·
Total Debt · · · $0 ·
Common Stock 5-point trend, +233.3% $10.0K $10.0K $10.0K $9.0K $3.0K
Paid-in Capital 5-point trend, +3621.1% $409M $380M $362M $349M $11M
Retained Earnings 5-point trend, -597.2% $-295M $-123M $-131M $-77M $-42M
AOCI 5-point trend, +125000.00 $125.0K $220.0K $49.0K $407.0K $0
Stockholders' Equity 5-point trend, +465.4% $114M $257M $231M $273M $-31M
Liabilities + Equity 5-point trend, +433.2% $328M $351M $233M $281M $61M
Shares Outstanding 5-point trend, +226.9% 99,290,926 97,954,172 96,414,963 93,943,316 30,369,413
Cash Flow 12
Annual Cash Flow data for SPRY
Metric Trend 20252024202320222021
D&A 5-point trend, +541.8% $1M $79.0K $100.0K $319.0K $213.0K
Stock-based Comp 5-point trend, +681.0% $22M $15M $9M $6M $3M
Deferred Tax Flat — no change across 3 periods $0 $0 $0 · ·
Amort. of Intangibles 2-point trend, +700.0% $800.0K $100.0K · · ·
Other Non-cash · · · $-12M ·
Operating Cash Flow 5-point trend, -873.0% $-171M $14M $-59M $-40M $-18M
CapEx 5-point trend, +516.4% $339.0K $563.0K $175.0K $199.0K $55.0K
Investing Cash Flow 5-point trend, +103314.5% $57M $-106M $-87M $-199.0K $-55.0K
Financing Cash Flow 5-point trend, +96.8% $105M $72M $7M $191M $53M
Net Change in Cash 5-point trend, -126.7% $-10M $-20M $-140M $150M $36M
Taxes Paid $200.0K · · · ·
Free Cash Flow 5-point trend, -151.3% $-171M $13M $-59M $-40M $-68M
Profitability 7
Annual Profitability data for SPRY
Metric Trend 20252024202320222021
Operating Margin 5-point trend, +99.7% -212.9% -3.5% -225066.7% -2698.8% -84513.2%
Net Margin 5-point trend, +99.8% -203.3% 9.0% -181216.7% -2635.4% -84413.2%
Pretax Margin 2-point trend, -2288.9% -203.4% 9.3% · · ·
EBITDA Margin 5-point trend, +99.7% -212.9% -3.5% -225066.7% -2674.5% -84513.2%
ROA 5-point trend, -105.4% -50.5% 2.7% -21.1% -20.2% -24.6%
ROE 5-point trend, -303.4% -111.8% 3.5% -23.2% -31.1% -27.7%
ROIC 2-point trend, -13432.8% -157.0% -1.2% · · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for SPRY
Metric Trend 20252024202320222021
Current Ratio 5-point trend, -58.6% 7.3 14.3 96.9 51.0 17.6
Quick Ratio 5-point trend, -59.5% 6.9 13.7 95.5 50.4 17.1
Debt / Equity · · · 0.0 ·
Efficiency 2
Annual Efficiency data for SPRY
Metric Trend 20252024202320222021
Asset Turnover 5-point trend, +82666.7% 0.2 0.3 0.0 0.0 0.0
Receivables Turnover 2-point trend, -76.9% 5.0 21.8 · · ·
Per Share 5
Annual Per Share data for SPRY
Metric Trend 20252024202320222021
Book Value / Share 5-point trend, -87.1% $1.15 $2.62 $2.39 $2.90 $8.94
Revenue / Share 4-point trend, +2498.8% $0.85 $0.87 $0.00 $0.03 ·
Cash Flow / Share 4-point trend, -72.8% $-1.73 $0.13 $-0.62 $-1.00 ·
Cash / Share 5-point trend, -94.2% $0.42 $0.52 $0.74 $2.24 $7.24
EPS (TTM) 5-point trend, -148.6% $-1.74 $0.08 $-0.57 $-0.87 $-0.70
Growth Rates 2
Annual Growth Rates data for SPRY
Metric Trend 20252024202320222021
Revenue YoY 4-point trend, +92.8% -5.5% 297063.3% -97.7% -76.1% ·
Revenue CAGR 3Y 2-point trend, +96.2% 300.1% 153.0% · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for SPRY
Metric Trend 20252024202320222021
Revenue TTM 5-point trend, +1430.7% $84M $89M $30.0K $1M $6M
Net Income TTM 5-point trend, -746.2% $-171M $8M $-54M $-35M $-20M
Market Cap 5-point trend, +394.7% $1.16B $1.03B $528M $801M $234M
Enterprise Value · · · $527M ·
P/E 5-point trend, +29.6% -6.7 131.9 -9.6 -9.8 -9.5
P/S 5-point trend, -67.7% 13.7 11.6 17611.8 608.9 42.5
P/B 5-point trend, +1258.7% 10.1 4.0 2.3 2.9 0.7
P / Tangible Book 4-point trend, +294.7% 11.6 4.1 2.3 2.9 ·
P / Cash Flow 5-point trend, -93.3% -6.8 76.3 -8.9 -20.0 -3.5
P / FCF 5-point trend, -96.9% -6.8 79.6 -8.9 -19.9 -3.4
EV / EBITDA · · · -15.0 ·
EV / FCF · · · -13.1 ·
EV / Revenue · · · 400.4 ·
Earnings Yield 5-point trend, -42.2% -14.9% 0.76% -10.4% -10.2% -10.5%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $84M$89M$30.0K$1M$6M
Operating Margin % -212.9%-3.5%-225066.7%-2698.8%-84513.2%
Net Income $-171M$8M$-54M$-35M$-20M
Diluted EPS $-1.74$0.08$-0.57$-0.87$-0.70
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.0
Current Ratio 7.314.396.951.017.6
Quick Ratio 6.913.795.550.417.1
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-171M$13M$-59M$-40M$-68M

My Metrics Your personal watchlist — selected rows from Full Fundamentals

📊

Pick the metrics that matter to you — click the ➕ next to any row in Full Fundamentals above.

Your selection is saved and follows you across all tickers.

Institutional owners (13F) 225 filers · $631.6M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
45 (+7 vs prior Q) 29 (+6 vs prior Q) 64 (+5 vs prior Q) 59 (+4 vs prior Q) +2.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
RA CAPITAL MANAGEMENT, L.P. $86,996,426 10,860,977 13.77% Shares
Rubric Capital Management LP $68,412,297 8,540,861 10.83% Shares
ORBIMED ADVISORS LLC $66,390,965 8,288,510 10.51% Shares
DEERFIELD MANAGEMENT COMPANY, L.P. $60,105,534 7,503,812 9.52% Shares
Tyro Capital Management LLC $35,719,289 4,459,337 5.66% Shares
Aberdeen Group plc $33,406,738 4,170,629 5.29% Shares
SR One Capital Management, LP $32,143,353 4,012,903 5.09% Shares
STATE STREET CORP $29,882,290 3,730,623 4.73% Shares
Capital World Investors $22,066,997 2,754,931 3.49% Shares
VANGUARD CAPITAL MANAGEMENT LLC $20,453,759 2,553,528 3.24% Shares
MILLENNIUM MANAGEMENT LLC $19,231,505 2,400,937 3.04% Shares
BOOTHBAY FUND MANAGEMENT, LLC $12,828,047 1,601,504 2.03% Shares
GEODE CAPITAL MANAGEMENT, LLC $11,722,344 1,463,070 1.86% Shares
Nextech Invest Ltd. $9,882,491 936,729 1.56% Shares
GENERAL AMERICAN INVESTORS CO INC $9,075,698 1,133,046 1.44% Shares
Third Point LLC $8,010,000 1,000,000 1.27% Shares
PEREGRINE CAPITAL MANAGEMENT LLC $5,383,833 672,139 0.85% Shares
Tejara Capital Ltd $4,862,382 607,039 0.77% Shares
ADAR1 Capital Management, LLC $4,814,002 600,999 0.76% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $4,540,300 566,829 0.72% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $4,416,842 551,416 0.70% Shares
LEVIN CAPITAL STRATEGIES, L.P. $4,397,210 548,965 0.70% Shares
Empire Life Investments Inc. $3,779,567 471,856 0.60% Shares
VANGUARD FIDUCIARY TRUST CO $3,692,618 461,001 0.58% Shares
FIL Ltd $3,649,156 455,575 0.58% Shares
Eversept Partners, LP $3,019,826 377,007 0.48% Shares
K2 PRINCIPAL FUND, L.P. $3,004,807 375,132 0.48% Shares
INVESTMENT MANAGEMENT ASSOCIATES INC /ADV $2,991,663 373,491 0.47% Shares
FMR LLC $2,796,692 349,150 0.44% Shares
Trexquant Investment LP $2,296,731 286,733 0.36% Shares
Jump Financial, LLC $2,044,152 255,200 0.32% Shares
BANK OF AMERICA CORP /DE/ $1,838,624 229,541 0.29% Shares
RAYMOND JAMES FINANCIAL INC $1,836,493 229,275 0.29% Shares
FAS Wealth Partners, Inc. $1,718,202 214,507 0.27% Shares
GOLDMAN SACHS GROUP INC $1,559,114 194,646 0.25% Shares
Quinn Opportunity Partners LLC $1,401,750 175,000 0.22% Shares
DAFNA Capital Management LLC $1,315,923 164,285 0.21% Shares
Ishara Investments LP $1,149,355 143,490 0.18% Shares
MORGAN STANLEY $1,127,255 140,731 0.18% Shares
Engineers Gate Manager LP $1,116,746 139,419 0.18% Shares
Steward Partners Investment Advisory, LLC $1,030,086 128,600 0.16% Shares
AMERICAN ASSETS INC $1,001,250 125,000 0.16% Shares
Quantinno Capital Management LP $996,676 124,429 0.16% Shares
BARCLAYS PLC $993,890 124,081 0.16% Shares
CenterBook Partners LP $990,228 123,624 0.16% Shares
MILLENNIUM MANAGEMENT LLC $961,200 120,000 0.15% Call option
DIMENSIONAL FUND ADVISORS LP $925,339 115,523 0.15% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $922,752 115,200 0.15% Call option
SEI INVESTMENTS CO $838,190 104,643 0.13% Shares
Parkman Healthcare Partners LLC $822,627 102,700 0.13% Shares
Swiss National Bank $757,746 94,600 0.12% Shares
Kodai Capital Management LP $756,196 60,111 0.12% Shares
Corient Private Wealth LP $733,366 91,556 0.12% Shares
CITIGROUP INC $686,016 85,645 0.11% Shares
VALLEY FORGE INVESTMENT CONSULTANTS INC ADV $666,633 83,225 0.11% Shares
RHUMBLINE ADVISERS $608,660 75,989 0.10% Shares
Headlands Technologies LLC $602,985 75,279 0.10% Shares
AssuredPartners Investment Advisors, LLC $586,816 73,260 0.09% Shares
XTX Topco Ltd $586,228 73,187 0.09% Shares
Norman Fields, Gottscho Capital Management, LLC $569,351 71,080 0.09% Shares
MARSHALL WACE, LLP $554,748 69,257 0.09% Shares
Matisse Capital $539,849 67,229 0.09% Shares
DIKER MANAGEMENT LLC $525,000 65,508 0.08% Shares
Balyasny Asset Management L.P. $517,911 64,658 0.08% Shares
Rafferty Asset Management, LLC $509,228 63,574 0.08% Shares
Bank of New York Mellon Corp $484,413 60,476 0.08% Shares
ALLIANCEBERNSTEIN L.P. $477,705 59,490 0.08% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $474,192 59,200 0.08% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $467,888 58,413 0.07% Shares
WELLS FARGO & COMPANY/MN $450,026 56,183 0.07% Shares
Coastal Bridge Advisors, LLC $447,262 55,838 0.07% Shares
ROYCE & ASSOCIATES LP $432,732 54,024 0.07% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $430,874 53,658 0.07% Shares
TWO SIGMA INVESTMENTS, LP $419,724 52,400 0.07% Shares
SCHULHOFF & CO INC $409,711 51,150 0.06% Shares
CITADEL ADVISORS LLC $406,315 50,726 0.06% Shares
K2 PRINCIPAL FUND, L.P. $384,480 48,000 0.06% Call option
AlphaQuest LLC $384,101 32,970 0.06% Shares
TUDOR INVESTMENT CORP ET AL $367,619 45,895 0.06% Shares
Permanent Capital Management, LP $347,498 43,383 0.06% Shares
BlackRock, Inc. $345,712 43,160 0.05% Shares
VANGUARD ASSET MANAGEMENT, Ltd $323,508 40,388 0.05% Shares
LETKO, BROSSEAU & ASSOCIATES INC $320,801 40,050 0.05% Shares
VANGUARD GROUP INC $317,567 27,259 0.05% Shares
MetLife Investment Management, LLC $293,518 36,644 0.05% Shares
Everstar Asset Management, LLC $270,193 33,732 0.04% Shares
VARCOV Co. $263,889 32,945 0.04% Shares
WINTON GROUP Ltd $263,529 32,900 0.04% Shares
PROFUND ADVISORS LLC $257,914 32,199 0.04% Shares
Verition Fund Management LLC $246,308 30,750 0.04% Shares
Cresset Asset Management, LLC $241,518 30,152 0.04% Shares
SECTORAL ASSET MANAGEMENT INC $239,499 29,900 0.04% Shares
CANADA PENSION PLAN INVESTMENT BOARD $237,096 29,600 0.04% Shares
ALLSTATE CORP $236,704 29,551 0.04% Shares
WOLVERINE TRADING, LLC $235,866 24,266 0.04% Shares
WOLVERINE TRADING, LLC $218,700 22,500 0.03% Call option
AXQ CAPITAL, LP $214,195 26,741 0.03% Shares
Vanguard Global Advisers, LLC $212,545 26,535 0.03% Shares
LPL Financial LLC $209,734 26,184 0.03% Shares
Private Advisor Group, LLC $209,002 26,092 0.03% Shares

Company insiders 26 insiders · 10 officers · 14 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Kathleen D. Scott Chief Financial Officer Jan. 2, 2024 A 8,250 0 0 $0
Jonathan Piazza Chief Financial Officer May 2, 2022 A 69,225 0 0 $0
Donn Casale President July 1, 2026 A 0 0 $0
Valerie Odegard President and CSO May 2, 2022 A 61,639 0 0 $0
Eric Karas Chief Commercial Officer June 12, 2026 M 12,176 0 1 $-250,000
Alexander A Fitzpatrick Chief Legal Officer June 12, 2026 S 90,910 0 1 $-33,550
Sarina Tanimoto Chief Medical Officer Jan. 2, 2024 A 2,100,000 0 0 $0
Justin Chakma Chief Business Officer Jan. 2, 2024 A 236,380 0 0 $0
Naomi Hunder Chief Medical Officer May 2, 2022 A 54,427 0 0 $0
Russ Hawkinson Sr. Vice President of Finance May 2, 2022 A 37,251 0 0 $0
Michael Kelly Director June 24, 2026 A 83,225 0 0 $0
Rajeev Dadoo Director June 24, 2026 A 3,009,677 0 0 $0
Pratik Shah Director June 24, 2026 A 0 0 $0
Saqib Islam Director June 24, 2026 A 0 0 $0
Laura Shawver Director June 24, 2026 A 210,346 0 0 $0
Peter A. Thompson Director June 24, 2026 A 0 0 0 $0
Brent L Saunders Director June 24, 2026 A 0 0 $0
Phillip M Schneider Director June 24, 2026 A 0 0 $0
Maria Koehler Director June 10, 2022 A 0 0 $0
Andrew Kenneth William Powell Director June 10, 2022 A 0 0 $0
Robert Hershberg Director June 10, 2022 A 0 0 $0
Vickie L Capps Director June 10, 2022 A 61,576 0 0 $0
Jonathan D Root Director June 10, 2022 A 2,364 0 0 $0
Thilo Schroeder Director Dec. 8, 2020 C 1,910,029 0 0 $0
Brian Dorsey Jan. 2, 2026 A 10,789 0 1 $-190,122
Richard E Lowenthal Jan. 2, 2026 A 2,100,000 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 8 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×4 filings Oct. 1, 2025 11.10% Amendment SEC
Deerfield Mgmt III, L.P., Deerfield Private Design Fund III, L.P., Deerfield Mgmt IV, L.P., Deerfield Private Design Fund IV, L.P., Deerfield Management Company, L.P., James E. Flynn ×5 filings Aug. 1, 2025 7.75% Amendment SEC
The Pratik Shah Living Trust dated June 15, 2011(1) ×3 filings June 17, 2024 Initial filing SEC
Robert G. Bell ×2 filings Sept. 1, 2023 Initial filing SEC
OrbiMed Advisors LLC, OrbiMed Capital GP VI LLC, OrbiMed Capital LLC ×2 filings Nov. 30, 2022 Initial filing SEC
Richard E. Lowenthal, M.S., MSEL Nov. 18, 2022 Initial filing SEC
Sarina Tanimoto, M.D., M.B.A. Nov. 18, 2022 Initial filing SEC
U.S. Venture Partners XII, L.P. (“USVP XII”), U.S. Venture Partners XII-A, L.P. (“USVP XII-A”), Presidio Management Group XII, L.L.C. (“PMG XII”), Casey M. Tansey, Jonathan D. Root ×2 filings Jan. 27, 2022 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 34 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
SBIO · ALPS ETF Trust 0.57% 102,352 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.20% 126,616 NS April 30, 2026 N-PORT
ESSC · Strategy Shares 0.05% 1,513 NS April 30, 2026 N-PORT
BIB · ProShares Trust 0.05% 3,656 NS May 31, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.04% 5,405 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.03% 66,043 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.03% 456,899 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.02% 564,385 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.01% 25,626 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.01% 2,777 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 310,998 NS May 31, 2026 N-PORT
IWM · iShares Trust 0.01% 1,576,075 SH Aug. 8, 2026 Daily
ISCV · iShares Trust 0.01% 13,569 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.01% 745,809 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 354,157 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 142,140 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.01% 2,171 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.01% 24,917 NS April 30, 2026 N-PORT
SMLF · iShares Trust 0.01% 51,570 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.01% 2,195 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 83,389 NS April 30, 2026 N-PORT
ISCB · iShares Trust 0.00% 2,495 SH Aug. 8, 2026 Daily
ONEQ · Fidelity Commonwealth Trust 0.00% 40,147 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 2,575 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 55 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.00% 2,822 SH Aug. 8, 2026 Daily
TILT · FlexShares Trust 0.00% 2,544 NS April 30, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 48,109 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 81,652 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 17,672 SH Aug. 8, 2026 Daily
DCOR · Dimensional ETF Trust 0.00% 692 NS April 30, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 6,032 NS April 30, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 1,749,763 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 4,489 SH Aug. 8, 2026 Daily