TGTX TG Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$51.09
Price · Aug 19, 2026
Fundamentals as of Aug 5, 2026

About TG Therapeutics, Inc. - Common Stock Company overview from Wikipedia

TGTX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$51.09
Market Cap
$7.93B
P/E (TTM)
18.4
EPS (TTM)
$2.77
Revenue (TTM)
$616M
Div Yield
ROE
96.7%
Debt/Equity
0.4
52W Range
$27 – $59

TGTX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $616M
10-point trend, +405352.0%
2016-12-31 2025-12-31
EPS $2.77
6-point trend, +214.5%
2020-12-31 2025-12-31
Free Cash Flow $-25M
8-point trend, +73.4%
2017-12-31 2025-12-31
Margins 72.6%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
TGTX
Peer Median
P/E (TTM)
5-point trend, +249.0%
18.4
16.0
P/S (TTM)
5-point trend, -100.0%
12.9
47.5
P/B
5-point trend, -49.3%
12.2
8.5
EV / EBITDA
5-point trend, +255.8%
65.1
Price / FCF
5-point trend, -444.4%
-317.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
TGTX
Peer Median
Operating Margin
5-point trend, +100.0%
20.0%
Net Profit Margin
5-point trend, +100.0%
72.6%
-140.2%
ROA
5-point trend, +176.9%
54.5%
-45.0%
ROE
5-point trend, +219.5%
96.7%
-86.5%
ROIC
5-point trend, +215.5%
57.5%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
TGTX
Peer Median
Debt / Equity
5-point trend, +538.2%
0.4
0.0
Current Ratio
5-point trend, -41.3%
4.1
5.8
Quick Ratio
5-point trend, -57.9%
2.9

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
TGTX
Peer Median
Revenue YoY
5-point trend, +9113.4%
87.3%
Revenue CAGR 3Y
5-point trend, +9113.4%
504.9%
Revenue CAGR 5Y
5-point trend, +9113.4%
426.7%
EPS YoY
5-point trend, +205.3%
1746.7%
Net Income YoY
5-point trend, +228.5%
1812.4%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
TGTX
Peer Median
EPS (Diluted)
5-point trend, +205.3%
$2.77

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
TGTX
Peer Median

TGTX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 14 analysts
  • Strong Buy 3 21.4%
  • Buy 9 64.3%
  • Hold 1 7.1%
  • Sell 1 7.1%
  • Strong Sell 0 0.0%

12-Month Price Target

7 analysts · 2026-08-18
Median target $75.00 +46.8%
Mean target $69.71 +36.5%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.15%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.05 $0.34 -0.29%
March 31, 2026 $0.18 $0.30 -0.12%
Dec. 31, 2025 $0.14 $0.36 -0.22%
Sept. 30, 2025 $0.16 $0.22 -0.06%
June 30, 2025 $0.17 $0.22 -0.05%
March 31, 2025 $0.03 $0.19 -0.16%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
TGTX $4.63B 10.8 87.3% 72.6% 96.7%
TWST $1.71B -21.6 20.3% -20.6% -17.0%
IBRX $2.00B -5.2 668.3% -310.2% 71.0%
RYTM $7.19B -34.4 45.8% -103.6% -309.1%
ORKA $1.48B -3.3 -25.9%
CGON $3.35B -20.0 254.7% -3985.0% -22.6%
SRRK $4.78B -13.4 -157.9%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Revenue 10-point trend, +405352.0% $616M $329M $234M $3M $7M $152.0K $152.0K $152.0K $152.0K $152.0K
Cost of Revenue 5-point trend, +12648.6% $101M $38M $14M $265.0K $790.0K · · · · ·
R&D Expense 10-point trend, +131.4% $160M $94M $76M $125M $223M $166M $154M $159M $103M $69M
SG&A Expense 10-point trend, +2246.4% $232M $154M $123M $95M $128M $108M $15M $15M $16M $10M
Operating Expenses 10-point trend, +523.0% $493M $287M $213M $221M $351M $274M $169M $175M $119M $79M
Operating Income 10-point trend, +256.2% $123M $42M $21M $-218M $-345M $-274M $-169M $-174M $-119M $-79M
Interest Expense 7-point trend, +1392.9% · · $13M $10M $6M $6M $5M $877.0K $845.0K ·
Other Non-op 10-point trend, +1407.4% $11M $8M $5M $5M $2M $-6M $-4M $918.0K $236.0K $716.0K
Pretax Income 10-point trend, +237.2% $107M $26M $13M $-224M $-348M $-279.4K $-172.9K $-173.5K $-118.5K $-78M
Income Tax 10-point trend, -339789000.00 $-340M $2M $390.0K $0 $0 $0 $0 $0 $0 $0
Net Income 8-point trend, +357.8% $447M $23M $13M $-224M $-348M $-279M $-173M $-173M · ·
EPS (Basic) 6-point trend, +228.1% $3.10 $0.16 $0.09 $-1.65 $-2.63 $-2.42 · · · ·
EPS (Diluted) 6-point trend, +214.5% $2.77 $0.15 $0.09 $-1.65 $-2.63 $-2.42 · · · ·
Shares (Basic) 6-point trend, +25.1% 144,316,786 145,317,418 141,955,112 135,411,258 132,222,753 115,333,693 · · · ·
Shares (Diluted) 6-point trend, +40.0% 161,412,746 160,336,051 148,508,465 135,411,258 132,222,753 115,333,693 · · · ·
EBITDA 8-point trend, +203.9% $123M $42M · $-193M $-345M $-274M $-169M $-174M $-119M ·
Balance Sheet 25
Annual Balance Sheet data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Cash & Equivalents 10-point trend, +216.2% $79M $180M $93M $102M $299M $553M $113M $42M $57M $25M
Short-term Investments 10-point trend, +216.4% $63M $131M $125M $59M $16M $52M $28M $27M $28M $20M
Receivables 5-point trend, +21903.5% $306M $129M $51M $0 $1M · · · · ·
Inventory 4-point trend, +125586000.00 $126M $110M $40M $0 · · · · · ·
Other Current Assets 10-point trend, +26508.5% $58M $16M $10M $2M $3M $1M $611.0K $439.0K $437.0K $216.4K
Current Assets 10-point trend, +1140.1% $631M $566M $318M $168M $331M $612M $149M $79M $93M $51M
PP&E (Net) 8-point trend, -71.0% · · $95.0K $307.0K $600.0K $481.0K $282.0K $251.0K $248.0K $328.1K
Goodwill 8-point trend, -0.0% · · $799.0K $799.0K $799.0K $799.0K $799.0K $799.0K $799.0K $799.4K
Other Non-current Assets 5-point trend, +1143.5% $2M $2M $2M · · · · · $0 $164.4K
Total Assets 10-point trend, +1840.9% $1.06B $578M $330M $194M $380M $626M $163M $84M $97M $55M
Accounts Payable 10-point trend, +604.2% $108M $58M $38M $42M $51M $37M $30M $36M $26M $15M
Short-term Debt 5-point trend, +1261.9% · · · · · $938.0K $190.0K $67.0K $128.0K $68.9K
Current Liabilities 10-point trend, +811.0% $154M $91M $54M $53M $65M $88M $84M $39M $28M $17M
Capital Leases 8-point trend, +7021000.00 $7M $8M $9M $10M $10M $10M $10M $0 · ·
Other Non-current Liabilities 3-point trend, +0.00 · · · · · · $0 $18M $0 ·
Total Liabilities 10-point trend, +2095.4% $415M $355M $169M $135M $142M $106M $124M $60M $30M $19M
Long-term Debt 5-point trend, +246.6% · · $100M $71M $68M $30M $29M · · ·
Total Debt 8-point trend, +192390.6% $246M $244M · $71M $68M $31M $29M $67.0K $127.6K ·
Common Stock 10-point trend, +179.8% $159.0K $156.0K $151.0K $146.0K $143.0K $141.0K $109.0K $84.0K $73.0K $56.8K
Paid-in Capital 10-point trend, +571.8% $1.83B $1.76B $1.71B $1.59B $1.57B $1.50B $740M $553M $422M $272M
Retained Earnings 10-point trend, -357.7% $-1.08B $-1.53B $-1.55B $-1.53B $-1.33B $-981M $-701M $-528M $-355M $-236M
Treasury Stock 10-point trend, +42735.0% $100M $9M $234.0K $234.0K $234.0K $234.0K $234.0K $234.0K $234.0K $234.0K
Stockholders' Equity 10-point trend, +1706.7% $648M $222M $161M $59M $237M $519M $39M $24M $67M $36M
Liabilities + Equity 10-point trend, +1840.9% $1.06B $578M $330M $194M $380M $626M $163M $84M $97M $55M
Shares Outstanding 10-point trend, +173.5% 155,305,953 155,836,256 151,424,289 146,385,388 143,250,734 140,576,297 109,383,934 83,870,546 73,140,441 56,779,114
Cash Flow 15
Annual Cash Flow data for TGTX
Metric Trend 2025202420232022202120202019201820172016
D&A 5-point trend, -79.1% $59.0K $68.0K $211.0K $303.0K $282.0K · · · · ·
Stock-based Comp 10-point trend, +762.3% $65M $43M $38M $45M $61M $80M $11M $13M $16M $8M
Deferred Tax 5-point trend, -348000000.00 $-348M $0 $0 · · $0 $0 · · ·
Amort. of Intangibles 4-point trend, +16.5% · · · $212.0K $212.0K $216.0K $182.0K · · ·
Other Non-cash 2-point trend, -77.1% $-189M $-107M · · · · · · · ·
Operating Cash Flow 10-point trend, +59.8% $-25M $-41M $-31M $-176M $-296M $-215M $-133M $-129M $-94M $-62M
CapEx 10-point trend, -37.8% $214.0K $45.0K $0 $14.0K $401.0K $357.0K $131.0K $90.0K $2.0K $344.0K
Investing Cash Flow 9-point trend, +268.1% $14M $-1M $-51M $-20M $-332.0K $-25M $-718.0K $1M $-8M ·
Stock Issued 5-point trend, -100.0% $0 $0 $46M $0 $2M · · · · ·
Net Stock Activity $0 · · · · · · · · ·
Financing Cash Flow 9-point trend, -167.1% $-90M $129M $73M $-391.0K $41M $680M $204M $114M $134M ·
Net Change in Cash 10-point trend, -235.4% $-101M $87M $-9M $-197M $-255M $441M $71M $-14M $32M $-30M
Taxes Paid 4-point trend, +7879000.00 $8M $500.0K $0 $0 · · · · · ·
Free Cash Flow 8-point trend, +73.4% $-25M $-41M · $-176M $-296M $-215M $-133M $-129M $-94M ·
Levered FCF 4-point trend, -34.8% · · · $-186M $-302M $-221M $-138M · · ·
Profitability 7
Annual Profitability data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Operating Margin 7-point trend, +100.0% 20.0% 12.7% · -6924.2% -5154.3% -179996.0% -111220.4% -114736.8% · ·
Net Margin 5-point trend, +100.0% 72.6% 7.1% · -7121.5% -5204.1% -183803.3% · · · ·
Pretax Margin 7-point trend, +100.0% 17.4% 7.8% · -7121.5% -5204.1% -183803.3% -113730.9% -114132.9% · ·
EBITDA Margin 7-point trend, +100.0% 20.0% 12.8% · -6924.2% -5154.3% -179996.0% -111220.4% -114736.8% · ·
ROA 5-point trend, +176.9% 54.5% 5.1% · -69.2% -69.3% -70.9% · · · ·
ROE 5-point trend, +219.5% 96.7% 11.3% · -249.4% -126.9% -81.0% · · · ·
ROIC 8-point trend, +132.5% 57.5% 8.2% · -148.7% -113.1% -49.7% -249.4% -723.6% -176.9% ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Current Ratio 8-point trend, +22.9% 4.1 6.2 · 3.2 5.1 7.0 1.8 2.0 3.3 ·
Quick Ratio 8-point trend, -3.9% 2.9 4.9 · 3.0 4.8 6.9 1.7 1.8 3.0 ·
Debt / Equity 8-point trend, +19852.6% 0.4 1.1 · 1.2 0.3 0.1 0.8 0.0 0.0 ·
LT Debt / Equity 6-point trend, -49.5% 0.4 1.1 · 1.2 0.3 0.0 0.8 · · ·
Interest Coverage 4-point trend, +40.8% · · · -18.9 -61.2 -43.2 -32.0 · · ·
Efficiency 3
Annual Efficiency data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Asset Turnover 7-point trend, +44082.4% 0.8 0.7 · 0.0 0.0 0.0 0.0 0.0 · ·
Inventory Turnover 2-point trend, +66.6% 0.9 0.5 · · · · · · · ·
Receivables Turnover 3-point trend, -70.6% 2.8 3.6 · · 9.6 · · · · ·
Per Share 5
Annual Per Share data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Book Value / Share 8-point trend, +355.5% $4.17 $1.43 · $0.40 $1.66 $3.69 $0.35 $0.29 $0.92 ·
Revenue / Share 3-point trend, +18434.5% $3.82 $2.05 · $0.02 · · · · · ·
Cash Flow / Share 3-point trend, +88.2% $-0.15 $-0.25 · $-1.30 · · · · · ·
Cash / Share 8-point trend, -34.3% $0.51 $1.15 · $0.70 $2.09 $3.94 $1.03 $0.50 $0.78 ·
EPS (TTM) 6-point trend, +214.5% $2.77 $0.15 $0.09 $-1.65 $-2.63 $-2.42 · · · ·
Growth Rates 5
Annual Growth Rates data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Revenue YoY 5-point trend, -98.0% 87.3% 40.8% 8290.0% -58.4% 4300.7% · · · · ·
Revenue CAGR 3Y 3-point trend, -52.1% 504.9% 266.4% 1054.1% · · · · · · ·
Revenue CAGR 5Y 426.7% · · · · · · · · ·
EPS YoY 2-point trend, +2519.9% 1746.7% 66.7% · · · · · · · ·
Net Income YoY 2-point trend, +2044.4% 1812.4% 84.5% · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for TGTX
Metric Trend 2025202420232022202120202019201820172016
Revenue TTM 10-point trend, +405352.0% $616M $329M $234M $3M $7M $152.0K $152.0K $152.0K $152.0K $152.0K
Net Income TTM 10-point trend, +671.5% $447M $23M $13M $-224M $-348M $-279M $-173M $-173M $-118M $-78M
Market Cap 8-point trend, +671.9% $4.63B $4.69B · $1.73B $2.72B $7.31B $1.21B $344M $600M ·
Enterprise Value 8-point trend, +818.8% $4.73B $4.62B · $1.64B $2.47B $6.74B $1.10B $275M $515M ·
P/E 6-point trend, +150.1% 10.8 200.7 189.8 -7.2 -7.2 -21.5 · · · ·
P/S 8-point trend, -99.8% 7.5 14.3 · 621.8 406.9 48110.4 7987.9 2262.3 3945.7 ·
P/B 8-point trend, -20.2% 7.1 21.1 · 29.6 11.5 14.1 31.4 14.3 9.0 ·
P / Tangible Book 6-point trend, -49.3% 7.1 21.1 16.2 30.0 11.5 14.1 · · · ·
P / Cash Flow 8-point trend, -2821.8% -186.9 -115.8 · -9.8 -9.2 -34.1 -9.1 -2.7 -6.4 ·
P / FCF 8-point trend, -2796.8% -185.3 -115.6 · -9.8 -9.2 -34.0 -9.1 -2.7 -6.4 ·
EV / EBITDA 8-point trend, +984.0% 38.4 110.1 · -8.5 -7.2 -24.6 -6.5 -1.6 -4.3 ·
EV / FCF 8-point trend, -3348.1% -189.4 -114.0 · -9.3 -8.4 -31.4 -8.3 -2.1 -5.5 ·
EV / Revenue 8-point trend, -99.8% 7.7 14.1 · 589.3 370.0 44330.2 7255.8 1810.1 3389.2 ·
Earnings Yield 6-point trend, +299.8% 9.3% 0.50% 0.53% -14.0% -13.8% -4.7% · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $616M$329M$234M$3M$7M
Operating Margin % 20.0%12.7%-6924.2%-5154.3%
Net Income $447M$23M$13M$-224M$-348M
Diluted EPS $2.77$0.15$0.09$-1.65$-2.63
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.41.11.20.3
Current Ratio 4.16.23.25.1
Quick Ratio 2.94.93.04.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-25M$-41M$-176M$-296M

Latest News Recent headlines mentioning this company

Trading Signals Recent buy/sell signals with entry price and risk/reward ratio

My Metrics Your personal watchlist — selected rows from Full Fundamentals

📊

Pick the metrics that matter to you — click the ➕ next to any row in Full Fundamentals above.

Your selection is saved and follows you across all tickers.

Institutional owners (13F) 483 filers · $4.0B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
120 (+45 vs prior Q) 32 (-12 vs prior Q) 149 (+15 vs prior Q) 121 (+11 vs prior Q) +18.2M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
VANGUARD PORTFOLIO MANAGEMENT LLC $437,501,834 7,963,266 11.02% Shares
STATE STREET CORP $427,788,717 7,786,471 10.77% Shares
VANGUARD CAPITAL MANAGEMENT LLC $337,848,201 6,149,403 8.51% Shares
GEODE CAPITAL MANAGEMENT, LLC $172,383,681 3,137,085 4.34% Shares
Soleus Capital Management, L.P. $160,858,551 2,927,895 4.05% Shares
Clearbridge Investments, LLC $145,601,554 2,650,192 3.67% Shares
CONGRESS ASSET MANAGEMENT CO $142,850,758 2,600,123 3.60% Shares
TWO SIGMA INVESTMENTS, LP $135,645,267 2,468,971 3.42% Shares
Pictet Asset Management Holding SA $98,120,148 1,785,951 2.47% Shares
Hood River Capital Management LLC $87,932,019 1,600,510 2.21% Shares
D. E. Shaw & Co., Inc. $84,535,574 1,538,689 2.13% Shares
GOLDMAN SACHS GROUP INC $77,247,783 1,406,039 1.95% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $74,762,352 1,360,800 1.88% Call option
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $72,141,879 1,313,103 1.82% Shares
DIMENSIONAL FUND ADVISORS LP $62,418,323 1,136,119 1.57% Shares
FMR LLC $55,894,473 1,017,373 1.41% Shares
VANGUARD FIDUCIARY TRUST CO $52,838,545 961,750 1.33% Shares
BARCLAYS PLC $52,418,363 954,102 1.32% Shares
BNP PARIBAS FINANCIAL MARKETS $47,275,870 860,500 1.19% Shares
BANK OF AMERICA CORP /DE/ $39,518,507 719,303 1.00% Shares
Woodline Partners LP $39,309,570 715,500 0.99% Shares
RENAISSANCE TECHNOLOGIES LLC $37,320,742 679,300 0.94% Shares
Penn Capital Management Company, LLC $29,505,770 536,067 0.74% Shares
Opaleye Management Inc. $29,392,900 535,000 0.74% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $28,876,464 525,600 0.73% Put option
VANGUARD GROUP INC $28,405,234 952,876 0.72% Shares
WELLINGTON MANAGEMENT GROUP LLP $24,907,818 453,364 0.63% Shares
Public Sector Pension Investment Board $24,877,766 452,817 0.63% Shares
Bridgewater Associates, LP $23,618,926 429,904 0.59% Shares
Occam Crest Management LP $22,729,000 425,000 0.57% Shares
NEW YORK STATE COMMON RETIREMENT FUND $22,429,530 408,255 0.56% Shares
JANE STREET GROUP, LLC $22,364,316 407,068 0.56% Shares
683 Capital Management, LLC $21,376,111 389,081 0.54% Shares
CITADEL ADVISORS LLC $20,970,598 381,700 0.53% Call option
CITIGROUP INC $20,859,839 379,684 0.53% Shares
Weiss Asset Management LP $20,607,005 375,082 0.52% Shares
FRONTIER CAPITAL MANAGEMENT CO LLC $20,262,586 368,813 0.51% Shares
JANE STREET GROUP, LLC $19,196,036 349,400 0.48% Put option
RHUMBLINE ADVISERS $18,253,780 332,250 0.46% Shares
BlackRock, Inc. $17,908,407 325,963 0.45% Shares
TWO SIGMA ADVISERS, LP $17,874,076 599,600 0.45% Shares
CITADEL ADVISORS LLC $17,679,692 321,800 0.45% Put option
Swiss National Bank $16,300,698 296,700 0.41% Shares
Marex Group Ltd $15,173,219 276,178 0.38% Shares
MILLENNIUM MANAGEMENT LLC $14,971,754 272,511 0.38% Shares
Point72 Asset Management, L.P. $14,557,067 264,963 0.37% Shares
JANE STREET GROUP, LLC $14,201,990 258,500 0.36% Call option
RAYMOND JAMES FINANCIAL INC $14,019,198 255,173 0.35% Shares
ACT CAPITAL MANAGEMENT, LLC $13,791,314 251,025 0.35% Shares
AMERIPRISE FINANCIAL INC $13,114,507 238,706 0.33% Shares
IFP Advisors, Inc $11,499,931 209,318 0.29% Shares
Legal & General Group Plc $11,165,236 203,226 0.28% Shares
Walleye Capital LLC $10,455,192 190,302 0.26% Shares
COMMONWEALTH EQUITY SERVICES, LLC $10,273,080 186,987 0.26% Shares
1832 Asset Management L.P. $10,235,322 186,300 0.26% Shares
Squarepoint Ops LLC $9,173,607 166,975 0.23% Shares
FIRST TRUST ADVISORS LP $9,155,970 166,654 0.23% Shares
Exome Asset Management LLC $9,060,430 164,915 0.23% Shares
ExodusPoint Capital Management, LP $9,038,344 164,513 0.23% Shares
PRUDENTIAL FINANCIAL INC $8,873,909 161,520 0.22% Shares
Trexquant Investment LP $8,351,155 152,005 0.21% Shares
CASTLEARK MANAGEMENT LLC $8,295,391 150,990 0.21% Shares
VANGUARD ASSET MANAGEMENT, Ltd $7,957,565 144,841 0.20% Shares
WELLS FARGO & COMPANY/MN $7,548,591 137,397 0.19% Shares
LPL Financial LLC $7,446,897 135,546 0.19% Shares
Man Group plc $7,272,737 132,376 0.18% Shares
UBS Group AG $7,114,290 129,492 0.18% Shares
SEGALL BRYANT & HAMILL, LLC $7,065,119 128,597 0.18% Shares
OSAIC HOLDINGS, INC. $6,954,000 126,579 0.18% Shares
INTECH INVESTMENT MANAGEMENT LLC $6,848,051 124,646 0.17% Shares
ENVESTNET ASSET MANAGEMENT INC $6,530,168 118,860 0.16% Shares
Squarepoint Ops LLC $6,444,462 117,300 0.16% Put option
ALLIANCEBERNSTEIN L.P. $6,306,186 189,831 0.16% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $5,838,415 175,750 0.15% Shares
Aquatic Capital Management LLC $5,468,178 99,530 0.14% Shares
Point72 Asset Management, L.P. $5,263,252 95,800 0.13% Call option
Summit Financial, LLC $5,235,949 95,303 0.13% Shares
TUDOR INVESTMENT CORP ET AL $5,159,965 93,920 0.13% Shares
Assenagon Asset Management S.A. $5,036,954 91,681 0.13% Shares
Bridge City Capital, LLC $4,883,946 88,896 0.12% Shares
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC $4,864,827 88,548 0.12% Shares
M28 Capital Management LP $4,854,169 88,354 0.12% Shares
Nuveen, LLC $4,787,581 87,142 0.12% Shares
STATE OF WISCONSIN INVESTMENT BOARD $4,778,132 86,970 0.12% Shares
PNC Financial Services Group, Inc. $4,761,320 86,664 0.12% Shares
VOYA INVESTMENT MANAGEMENT LLC $4,736,487 86,212 0.12% Shares
Quantum Private Wealth, LLC $4,725,280 86,008 0.12% Shares
VICTORY CAPITAL MANAGEMENT INC $4,686,218 85,297 0.12% Shares
MetLife Investment Management, LLC $4,651,220 84,660 0.12% Shares
JPMORGAN CHASE & CO $4,589,043 82,359 0.12% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $4,272,739 77,771 0.11% Shares
D. E. Shaw & Co., Inc. $4,268,838 77,700 0.11% Call option
Cetera Investment Advisers $4,223,952 76,883 0.11% Shares
DIADEMA PARTNERS LP $4,158,958 75,700 0.10% Call option
TUDOR INVESTMENT CORP ET AL $3,999,632 72,800 0.10% Put option
Edgestream Partners, L.P. $3,801,463 69,193 0.10% Shares
CAPITAL FUND MANAGEMENT S.A. $3,777,894 68,764 0.10% Shares
Cubist Systematic Strategies, LLC $3,704,549 102,548 0.09% Shares
Redwood Investments, LLC $3,676,532 93,242 0.09% Shares
Knott David M Jr $3,672,135 66,839 0.09% Shares

Company insiders 26 insiders · 4 officers · 16 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Michael S Weiss CEO and President Aug. 11, 2023 P 12,073,021 0 0 $0
Sean A Power Chief Financial Officer June 2, 2023 S 654,836 0 0 $0
Michael Mcguinness COO & CFO March 3, 2010 A 10,000 0 0 $0
Alan G Harris Chief Medical Officer April 25, 2007 A 0 0 $0
Sagar Lonial Director June 11, 2026 A 113,878 0 0 $0
Daniel Hume Director June 11, 2026 A 218,239 0 0 $0
Kenneth Hoberman Director June 11, 2026 A 242,685 0 0 $0
Yann Echelard Director June 11, 2026 A 221,848 0 0 $0
William James Kennedy Director June 22, 2020 A 109,633 0 0 $0
Mark Schoenebaum Director July 6, 2016 A 95,949 0 0 $0
Neil Herskowitz Director June 6, 2014 A 80,088 0 0 $0
David Shimko Director March 18, 2010 A 0 0 $0
Douglas Abel Director March 3, 2010 A 45,000 0 0 $0
Richard I Steinhart Director March 3, 2010 A 5,633 0 0 $0
Timothy Mcinerney Director March 3, 2010 A 674,007 0 0 $0
Joan Pons Gimbert Director Jan. 30, 2007 A 2,112 0 0 $0
Joshua A Kazam Director April 1, 2005 A 492,852 0 0 $0
David M Tanen Director April 1, 2005 A 602,517 0 0 $0
Leonard Mc Firestone Director Jan. 28, 2004 A 0 0 $0
LFB Biotechnologies S.A.S.U. 10% owner May 7, 2015 X 7,614,855 0 0 $0
Lindsay A. Rosenwald, M.D. 10% owner April 1, 2005 P 2,564,321 0 0 $0
Jay J Lobell 10% owner Nov. 7, 2003 P 0 0 $0
Laurence N Charney Aug. 7, 2026 G 173,640 0 0 $0
Malcolm Hoenlein March 3, 2010 A 4,861 0 0 $0
Michael Weiser March 3, 2010 A 2,292,241 0 0 $0
Nicholas J Rossettos Jan. 11, 2005 A 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 6 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
LFB Biotechnologies, S.A.S.U. ×2 filings July 11, 2018 Initial filing SEC
LFB Biotechnologies, S.A.S. ×2 filings May 11, 2015 Initial filing Board campaign SEC
Opus Point Partners, LLC*, Michael S. Weiss* ×3 filings Aug. 28, 2012 Initial filing SEC
Nordic Biotech Venture Fund II K/S (2), Nordic Biotech General Partner II (2), Christian Hansen (2), Florian Schönharting (2) ×3 filings Jan. 24, 2011 Initial filing SEC
Undisclosed reporting person March 5, 2008 Initial filing SEC
Lester E. Lipschutz April 8, 2005 Initial filing M&A / sale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 67 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
PSCH · Invesco Exchange-Traded Fund Trust … 3.32% 114,392 SH Aug. 8, 2026 Daily
BBP · ETFis Series Trust I 1.72% 30,187 NS April 30, 2026 N-PORT
RNIN · EA Series Trust 1.29% 58,592 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 1.13% 173,080 NS April 30, 2026 N-PORT
XSHQ · Invesco Exchange-Traded Fund Trust … 1.09% 70,236 SH Aug. 8, 2026 Daily
RZG · Invesco Exchange-Traded Fund Trust 1.08% 30,240 SH Aug. 8, 2026 Daily
PTH · Invesco Exchange-Traded Fund Trust 0.97% 48,179 SH Aug. 8, 2026 Daily
VIOG · VANGUARD ADMIRAL FUNDS 0.79% 156,885 SH Aug. 8, 2026 Daily
IJT · iShares Trust 0.73% 1,223,039 SH Aug. 8, 2026 Daily
SIXL · EXCHANGE TRADED CONCEPTS TRUST 0.56% 28,101 NS May 31, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.47% 155,880 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.45% 1,321,030 SH Aug. 8, 2026 Daily
XJR · iShares Trust 0.41% 15,575 SH Aug. 8, 2026 Daily
FNY · First Trust Exchange-Traded AlphaDE… 0.40% 61,921 NS April 30, 2026 N-PORT
VIOO · VANGUARD ADMIRAL FUNDS 0.39% 460,826 SH Aug. 8, 2026 Daily
AFSM · First Trust Exchange-Traded Fund VI… 0.38% 9,842 NS May 31, 2026 N-PORT
IJR · iShares Trust 0.36% 8,037,685 SH Aug. 8, 2026 Daily
QVMS · Invesco Exchange-Traded Fund Trust … 0.34% 17,692 SH Aug. 8, 2026 Daily
OASC · Unified Series Trust 0.27% 6,075 NS May 31, 2026 N-PORT
TMFX · RBB Fund, Inc. 0.27% 2,291 NS May 31, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.24% 837,766 SH Aug. 8, 2026 Daily
SAA · ProShares Trust 0.23% 1,627 NS May 31, 2026 N-PORT
IWM · iShares Trust 0.23% 3,688,222 SH Aug. 8, 2026 Daily
BKSE · BNY Mellon ETF Trust 0.22% 5,373 NS April 30, 2026 N-PORT
ISCG · iShares Trust 0.22% 45,253 SH Aug. 8, 2026 Daily
VBK · VANGUARD INDEX FUNDS 0.21% 1,825,086 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.20% 50,951 NS May 31, 2026 N-PORT
SMDX · Tidal Trust III 0.15% 5,751 NS April 30, 2026 N-PORT
RSSL · Global X Funds 0.15% 62,865 NS April 30, 2026 N-PORT
FNX · First Trust Exchange-Traded AlphaDE… 0.14% 54,646 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.14% 6,835 NS May 31, 2026 N-PORT
VHT · VANGUARD WORLD FUND 0.12% 443,566 SH Aug. 8, 2026 Daily
FAD · First Trust Exchange-Traded AlphaDE… 0.12% 17,027 NS April 30, 2026 N-PORT
SXQG · EXCHANGE TRADED CONCEPTS TRUST 0.12% 2,092 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.11% 6,433 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.11% 652,513 NS May 31, 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0.10% 6,048 SH Aug. 8, 2026 Daily
BBMC · J.P. Morgan Exchange-Traded Fund Tr… 0.10% 58,618 NS April 30, 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0.09% 3,160,081 SH Aug. 8, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.08% 69,640 NS April 30, 2026 N-PORT
UWM · ProShares Trust 0.08% 5,346 NS May 31, 2026 N-PORT
SMLF · iShares Trust 0.08% 69,410 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.08% 1,511,242 SH Aug. 8, 2026 Daily
ESML · iShares Trust 0.08% 46,017 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.08% 43,583 SH Aug. 8, 2026 Daily
AFMC · First Trust Exchange-Traded Fund VI… 0.07% 2,936 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.07% 8,992 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.06% 5,408 NS May 31, 2026 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0.05% 126 NS May 31, 2026 N-PORT
RWJ · Invesco Exchange-Traded Fund Trust … 0.05% 19,387 SH Aug. 8, 2026 Daily