TVTX Travere Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$64.91
Price · Aug 19, 2026
Fundamentals as of Aug 4, 2026

TVTX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$64.91
Market Cap
$5.90B
P/E (TTM)
-223.8
EPS (TTM)
$-0.29
Revenue (TTM)
$491M
Div Yield
ROE
-34.6%
Debt/Equity
52W Range
$17 – $66

TVTX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $491M
10-point trend, +267.3%
2016-12-31 2025-12-31
EPS $-0.29
10-point trend, +77.5%
2016-12-31 2025-12-31
Free Cash Flow
8-point trend, -9182.0%
2016-12-31 2023-12-31
Margins -5.2%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
TVTX
Peer Median
P/E (TTM)
5-point trend, -1177.7%
-223.8
37.2
P/S (TTM)
5-point trend, -51.9%
12.0
9.9
P/B
5-point trend, +371.2%
51.4
8.3

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
TVTX
Peer Median
Operating Margin
5-point trend, +82.0%
-12.8%
Net Profit Margin
5-point trend, +93.4%
-5.2%
-15.1%
ROA
5-point trend, +83.6%
-4.3%
-23.3%
ROE
5-point trend, +41.4%
-34.6%
-30.6%
ROIC
5-point trend, -4.0%
-55.8%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
TVTX
Peer Median
Current Ratio
5-point trend, -41.7%
2.7
6.3
Quick Ratio
5-point trend, -26.0%
1.1

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
TVTX
Peer Median
Revenue YoY
5-point trend, +272.2%
110.5%
Revenue CAGR 3Y
5-point trend, +272.2%
64.9%
Revenue CAGR 5Y
5-point trend, +272.2%
19.9%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
TVTX
Peer Median
EPS (Diluted)
5-point trend, +90.4%
$-0.29

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
TVTX
Peer Median

TVTX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 21 analysts
  • Strong Buy 8 38.1%
  • Buy 11 52.4%
  • Hold 2 9.5%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

14 analysts · 2026-08-14
Median target $75.00 +15.5%
Mean target $72.79 +12.1%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.16%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.06 $-0.14 0.20%
March 31, 2026 $-0.40 $-0.27 -0.13%
Dec. 31, 2025 $0.03 $-0.12 0.15%
Sept. 30, 2025 $0.28 $-0.21 0.49%
June 30, 2025 $-0.14 $-0.30 0.16%
March 31, 2025 $-0.47 $-0.55 0.08%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
TVTX $3.47B -131.8 110.5% -5.2% -34.6%
ERAS $1.06B -8.5 -35.7%
SRRK $4.78B -13.4 -157.9%
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8%
CAI $7.62B -8.4 97.0% -8.4% -13.2%
PTCT $6.19B 9.8 114.5% 39.4% -331.5%
ACAD $4.55B 11.6 11.9% 36.5% 38.1%
DYN $3.23B -5.6 -57.8%
CELC $4.81B -26.3 -244.3%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +1640.0% $491M $233M $145M $109M $132M $198M $175M $164M $155M $134M $100M $28M
Cost of Revenue 12-point trend, +1710.7% $10M $8M $11M $4M $4M $6M $5M $6M $4M $5M $2M $571.0K
R&D Expense 7-point trend, -84.3% · · · $8M · · $141M $124M $78M $71M $50M $48M
SG&A Expense 12-point trend, +465.3% $337M $264M $266M $198M $126M $136M $129M $104M $101M $92M $80M $60M
Operating Expenses 12-point trend, +412.5% $554M $557M $533M $429M $331M $374M $313M $244M $209M $192M $151M $108M
Operating Income 12-point trend, +21.3% $-63M $-324M $-388M $-320M $-199M $-176M $-137M $-80M $-54M $-58M $-51M $-80M
Interest Expense 10-point trend, +52.7% · · $11M $11M $20M $19M $19M $10M $4M $5M $8M $7M
Interest Income 9-point trend, +293.4% $13M $18M $22M $6M $2M $5M $10M $5M $3M · · ·
Other Non-op 12-point trend, +392.3% $12M $-3M $2M $974.0K $231.0K $1M $-314.0K $-474.0K $1M $-264.0K $-296.0K $2M
Pretax Income 12-point trend, +56.5% $-49M $-321M $-376M $-331M $-217M $-189M $-146M $-102M $-58M $-58M $105M $-113M
Income Tax 12-point trend, +140.2% $988.0K $120.0K $223.0K $313.0K $409.0K $-19M $-21.0K $811.0K $1M $-10M $-12M $-2M
Net Income 12-point trend, +77.0% $-26M $-322M $-111M $-278M $-180M $-169M $-146M $-103M $-60M $-48M $117M $-111M
EPS (Basic) 12-point trend, +93.5% $-0.29 $-4.08 $-1.50 $-4.37 $-3.01 $-3.56 $-3.46 $-2.54 $-1.54 $-1.29 $3.49 $-4.43
EPS (Diluted) 12-point trend, +93.5% $-0.29 $-4.08 $-1.50 $-4.37 $-3.01 $-3.56 $-3.46 $-2.54 $-1.54 $-1.29 $3.17 $-4.43
Shares (Basic) 12-point trend, +256.0% 89,211,813 78,888,861 74,267,418 63,758,515 59,832,287 47,539,631 42,339,961 40,433,171 38,769,816 36,997,865 33,560,249 25,057,509
Shares (Diluted) 12-point trend, +256.0% 89,211,813 78,888,861 74,267,418 63,758,515 59,832,287 47,539,631 42,339,961 40,433,171 38,769,816 38,288,012 37,581,439 25,057,509
EBITDA 10-point trend, +95.1% $-2M $-280M $-350M $-233M $-135M $-152M $-117M $-61M $-36M $-42M · ·
Balance Sheet 29
Annual Balance Sheet data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +411.1% $93M $59M $58M $62M $166M $85M $62M $103M $99M $41M $38M $18M
Short-term Investments 4-point trend, +2005.9% · · · · · · · · $201M $215M $192M $10M
Receivables 12-point trend, +906.7% $80M $27M $21M $17M $16M $16M $18M $13M $14M $19M $12M $8M
Inventory 12-point trend, +4413.7% $36M $42M $9M $5M $7M $8M $6M $6M $5M $3M $3M $801.0K
Prepaid Expense 12-point trend, +3437.5% $29M $13M $19M $12M $7M $8M $5M $4M $3M $5M $2M $813.0K
Current Assets 12-point trend, +1072.0% $438M $417M $617M $486M $583M $410M $429M $496M $326M $332M $302M $37M
PP&E (Net) 12-point trend, +499.4% $4M $5M $7M $9M $11M $9M $3M $3M $3M $3M $428.0K $671.0K
PP&E (Gross) 10-point trend, +406.6% $14M $14M $15M $14M $14M $13M $5M $4M $4M $3M · ·
Accum. Depreciation 10-point trend, +4949.0% $10M $9M $7M $5M $3M $4M $2M $1M $585.0K $200.0K · ·
Goodwill 11-point trend, -14.5% · $800.0K $800.0K $800.0K $900.0K $900.0K $936.0K $936.0K $936.0K $936.0K $936.0K $936.0K
Intangibles 12-point trend, +20.8% $114M $104M $104M $97M $148M $154M $157M $187M $185M $182M $162M $94M
Other Non-current Assets 12-point trend, +292.1% $9M $18M $11M $11M $11M $8M $15M $8M $6M $7M $2M $2M
Total Assets 12-point trend, +346.7% $605M $594M $789M $673M $777M $607M $605M $709M $520M $525M $512M $135M
Accounts Payable 12-point trend, +248.1% $25M $24M $42M $17M $15M $12M $27M $7M $19M $8M $8M $7M
Accrued Liabilities 12-point trend, +352.0% $126M $86M $119M $96M $75M $57M $52M $50M $36M $33M $24M $28M
Short-term Debt 2-point trend, -100.0% · · · · · · · · · · $0 $40M
Current Liabilities 12-point trend, +48.7% $160M $201M $178M $142M $124M $93M $95M $105M $86M $83M $87M $108M
Capital Leases 7-point trend, +50.6% $11M $17M $23M $28M $31M $28M $7M · · · · ·
Deferred Tax 4-point trend, -100.0% · · · · · · · · $0 $6M $24M $141.0K
Other Non-current Liabilities 12-point trend, +370.1% $8M $7M $10M $9M $12M $12M $21M $18M $2M $4M $3M $2M
Total Liabilities 12-point trend, +183.9% $490M $535M $588M $630M $475M $396M $384M $391M $227M $218M $212M $173M
Common Stock 12-point trend, +200.0% $9.0K $9.0K $7.0K $6.0K $6.0K $5.0K $4.0K $4.0K $4.0K $4.0K $4.0K $3.0K
Paid-in Capital 12-point trend, +1027.9% $1.59B $1.51B $1.33B $1.06B $1.07B $798M $637M $590M $472M $421M $366M $141M
Retained Earnings 12-point trend, -721.9% $-1.47B $-1.45B $-1.13B $-1.01B $-766M $-586M $-416M $-270M $-178M $-113M $-65M $-179M
Treasury Stock 2-point trend, -100.0% · · · · · · · · · · $0 $3M
AOCI 12-point trend, -127.7% $-1M $-80.0K $-1M $-3M $-562.0K $-902.0K $726.0K $-2M $-1M $-490.0K $-682.0K $4M
Stockholders' Equity 12-point trend, +408.3% $115M $59M $201M $43M $302M $211M $221M $318M $293M $308M $300M $-37M
Liabilities + Equity 12-point trend, +346.7% $605M $594M $789M $673M $777M $607M $605M $709M $520M $525M $512M $135M
Shares Outstanding 12-point trend, +249.1% 90,922,868 87,452,835 75,367,117 64,290,570 62,491,498 52,248,431 43,088,921 41,389,524 39,373,745 37,906,669 36,465,853 26,048,480
Cash Flow 18
Annual Cash Flow data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, +1024.7% $61M $44M $39M $21M $13M $25M $20M $19M $18M $16M $13M $5M
Stock-based Comp 12-point trend, +182.2% $45M $37M $44M $38M $30M $24M $21M $20M $27M $29M $26M $16M
Deferred Tax 12-point trend, +100.0% $0 $0 $0 $0 $0 $0 $0 $0 $-6M $-23M $-16M $-2M
Amort. of Intangibles 12-point trend, +1021.8% $59M $42M $36M $19M $11M $22M $20M $18M $17M $16M $13M $5M
Restructuring 11-point trend, +0.00 $0 $2M $11M $0 $0 $0 $0 $-242.0K $4M $893.0K $0 ·
Other Non-cash 10-point trend, -278.2% $-42M $4M $-251M $20M $108M $78M $47M $39M $29M $24M · ·
Operating Cash Flow 12-point trend, +182.4% $38M $-237M $-280M $-186M $-15M $-43M $-58M $-25M $7M $-3M $-1M $-46M
CapEx 10-point trend, +0.8% · · $668.0K $191.0K $5M $7M $195.0K $727.0K $887.0K $1M $22.0K $663.0K
Investing Cash Flow 11-point trend, +134.6% $28M $99M $56M $-33M $-138M $-61M $20M $-203M $46M $10M $-81M ·
Net Debt Issued 3-point trend, +100.0% · · · · · $0 $0 $-40M · · · ·
Stock Issued 9-point trend, -100.0% $0 $135M $191M $0 $189M · · · $0 $0 $149M $40M
Stock Repurchased 3-point trend, -100.0% · · · · · · · · · $0 $0 $2M
Net Stock Activity 5-point trend, +0.00 $0 $135M $191M · · · · · $0 $0 · ·
Financing Cash Flow 12-point trend, -135.1% $-33M $139M $219M $118M $232M $128M $-2M $232M $5M $-4M $102M $95M
Net Change in Cash 12-point trend, +182.6% $34M $359.0K $-4M $-104M $81M $22M $-40M $3M $58M $3M $20M $12M
Taxes Paid 7-point trend, +107.8% · $453.0K $578.0K $996.0K $-16M $-3M $656.0K $218.0K · · · ·
Free Cash Flow 8-point trend, -9182.0% · · $-281M $-186M $-20M $-50M $-58M $-26M $7M $-3M · ·
Levered FCF 8-point trend, -7814.2% · · $-292M $-198M $-40M $-67M $-77M $-36M $5M $-4M · ·
Profitability 7
Annual Profitability data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 10-point trend, +70.6% -12.8% -138.9% -267.2% -125.7% -71.1% -88.8% -78.3% -48.7% -34.7% -43.6% · ·
Net Margin 10-point trend, +85.5% -5.2% -137.9% -76.7% -131.3% -79.2% -85.4% -83.5% -62.5% -38.6% -35.9% · ·
Pretax Margin 10-point trend, +76.7% -10.0% -137.5% -259.0% -131.2% -79.0% -95.2% -83.5% -62.0% -37.7% -43.1% · ·
EBITDA Margin 10-point trend, +98.7% -0.42% -120.2% -240.7% -110.1% -59.4% -76.4% -66.7% -37.4% -23.2% -31.5% · ·
ROA 9-point trend, +53.8% -4.3% -46.5% -15.2% -38.4% -26.0% -28.0% -22.3% -16.7% · -9.2% · ·
ROE 9-point trend, -119.7% -34.6% -2246.8% -46.4% -388.1% -59.1% -66.1% -62.7% -32.2% · -15.8% · ·
ROIC 9-point trend, -254.6% -55.8% -548.4% -193.4% -622.8% -53.7% -74.9% -62.1% -25.4% · -15.7% · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 9-point trend, -31.4% 2.7 2.1 3.5 3.4 4.7 4.4 4.5 4.7 · 4.0 · ·
Quick Ratio 9-point trend, -67.1% 1.1 0.4 0.4 0.6 1.5 1.1 0.8 1.1 · 3.3 · ·
Interest Coverage 8-point trend, +52.8% · · -34.3 -23.6 -8.0 -9.2 -7.3 -8.2 -44.8 -72.8 · ·
Efficiency 3
Annual Efficiency data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 9-point trend, +217.8% 0.8 0.3 0.2 0.3 0.3 0.3 0.3 0.3 · 0.3 · ·
Inventory Turnover 9-point trend, -84.4% 0.3 1.0 1.6 1.1 0.9 0.9 0.9 1.0 · 1.7 · ·
Receivables Turnover 9-point trend, +6.1% 9.2 9.7 7.7 13.0 14.3 11.7 11.4 11.6 · 8.6 · ·
Per Share 5
Annual Per Share data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 9-point trend, -84.4% $1.26 $0.68 $2.66 $0.67 $4.83 $4.04 $5.13 $7.69 · $8.12 · ·
Revenue / Share 8-point trend, +57.7% $5.50 $2.96 $1.96 $3.33 $3.80 · · $4.06 $4.00 $3.49 · ·
Cash Flow / Share 8-point trend, +1115.6% $0.42 $-3.01 $-3.77 $-2.92 $-0.25 · · $-0.62 $0.19 $-0.04 · ·
Cash / Share 9-point trend, -5.4% $1.02 $0.67 $0.77 $0.96 $2.65 $1.62 $1.45 $2.49 · $1.08 · ·
EPS (TTM) 12-point trend, +93.5% $-0.29 $-4.08 $-1.50 $-4.37 $-3.01 $-3.56 $-3.46 $-2.54 $-1.54 $-1.29 $3.17 $-4.43
Growth Rates 3
Annual Growth Rates data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +429.5% 110.5% 60.6% 32.7% -17.0% -33.5% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +758.1% 64.9% 20.9% -9.9% · · · · · · · · ·
Revenue CAGR 5Y 19.9% · · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for TVTX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +1640.0% $491M $233M $145M $109M $132M $198M $175M $164M $155M $134M $100M $28M
Net Income TTM 12-point trend, +77.0% $-26M $-322M $-111M $-278M $-180M $-169M $-146M $-103M $-60M $-48M $117M $-111M
Market Cap 9-point trend, +384.2% $3.47B $1.52B $678M $1.35B $1.94B $1.42B $612M $937M · $718M · ·
P/E 12-point trend, -4668.7% -131.8 -4.3 -6.0 -4.8 -10.3 -7.7 -4.1 -8.9 -13.7 -14.7 6.1 -2.8
P/S 9-point trend, +31.8% 7.1 6.5 4.7 12.4 14.7 7.2 3.5 5.7 · 5.4 · ·
P/B 9-point trend, +1197.7% 30.3 25.8 3.4 31.6 6.4 6.7 2.8 2.9 · 2.3 · ·
P / Tangible Book 4-point trend, +14179.2% 3618.9 · 7.1 · 12.7 25.3 · · · · · ·
P / Cash Flow 9-point trend, +120.5% 91.9 -6.4 -2.4 -7.3 -131.1 -33.3 -10.5 -37.5 · -449.6 · ·
P / FCF 7-point trend, +99.0% · · -2.4 -7.3 -97.5 -28.8 -10.5 -36.5 · -237.3 · ·
Earnings Yield 12-point trend, +97.9% -0.76% -23.4% -16.7% -20.8% -9.7% -13.1% -24.4% -11.2% -7.3% -6.8% 16.4% -36.2%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $491M$233M$145M$109M$132M
Operating Margin % -12.8%-138.9%-267.2%-125.7%-71.1%
Net Income $-26M$-322M$-111M$-278M$-180M
Diluted EPS $-0.29$-4.08$-1.50$-4.37$-3.01
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 2.72.13.53.44.7
Quick Ratio 1.10.40.40.61.5
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-281M$-186M$-20M

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Institutional owners (13F) 341 filers · $4.3B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
98 (+52 vs prior Q) 27 (-28 vs prior Q) 108 (+12 vs prior Q) 90 (-2 vs prior Q) +8.8M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $286,681,837 5,046,327 6.65% Shares
STATE STREET CORP $241,796,085 4,256,224 5.61% Shares
VANGUARD CAPITAL MANAGEMENT LLC $233,414,906 4,108,694 5.41% Shares
BANK OF AMERICA CORP /DE/ $218,865,524 3,852,588 5.08% Shares
VANGUARD GROUP INC $213,624,812 5,590,809 4.96% Shares
PERCEPTIVE ADVISORS LLC $213,183,729 3,752,574 4.94% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $159,779,000 2,812,514 3.71% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $145,965,114 2,569,356 3.39% Shares
Rock Springs Capital Management LP $123,792,910 2,179,069 2.87% Shares
GEODE CAPITAL MANAGEMENT, LLC $115,630,571 2,034,915 2.68% Shares
Kynam Capital Management, LP $113,620,000 2,000,000 2.64% Shares
Stephens Investment Management Group LLC $106,536,020 1,875,304 2.47% Shares
RENAISSANCE TECHNOLOGIES LLC $104,137,218 1,833,079 2.42% Shares
EMERALD ADVISERS, LLC $90,946,334 1,600,886 2.11% Shares
ARMISTICE CAPITAL, LLC $89,335,941 1,572,539 2.07% Shares
TWO SIGMA INVESTMENTS, LP $88,944,917 1,565,656 2.06% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $87,579,262 1,541,617 2.03% Shares
Qube Research & Technologies Ltd $81,989,896 1,443,230 1.90% Shares
Driehaus Capital Management LLC $81,757,203 1,439,134 1.90% Shares
BNP PARIBAS FINANCIAL MARKETS $65,726,898 1,156,960 1.52% Shares
MPM BIOIMPACT LLC $63,782,348 1,122,731 1.48% Shares
D. E. Shaw & Co., Inc. $62,429,361 1,098,915 1.45% Shares
EMERALD MUTUAL FUND ADVISERS TRUST $58,629,283 1,032,024 1.36% Shares
GOLDMAN SACHS GROUP INC $57,488,823 1,011,949 1.33% Shares
WELLINGTON MANAGEMENT GROUP LLP $56,379,267 992,418 1.31% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $46,997,663 827,278 1.09% Shares
Eversept Partners, LP $45,389,656 798,973 1.05% Shares
VANGUARD FIDUCIARY TRUST CO $37,598,221 661,824 0.87% Shares
Ensign Peak Advisors, Inc $33,621,010 591,815 0.78% Shares
ARMISTICE CAPITAL, LLC $28,405,000 500,000 0.66% Call option
PANAGORA ASSET MANAGEMENT INC $27,878,030 490,724 0.65% Shares
TWO SIGMA ADVISERS, LP $27,721,355 725,500 0.64% Shares
Point72 Asset Management, L.P. $27,204,037 478,860 0.63% Shares
Candriam S.C.A. $26,690,051 470,265 0.62% Shares
Graham Capital Management, L.P. $25,376,800 446,696 0.59% Shares
Assenagon Asset Management S.A. $24,275,197 427,305 0.56% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $22,086,489 378,842 0.51% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $21,854,807 384,700 0.51% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $21,565,076 379,600 0.50% Call option
Integral Health Asset Management, LLC $21,303,750 375,000 0.49% Shares
Pictet Asset Management Holding SA $20,067,022 344,510 0.47% Shares
Artia Global Partners LP $19,260,465 339,033 0.45% Shares
Capricorn Fund Managers Ltd $18,276,970 321,721 0.42% Shares
JANE STREET GROUP, LLC $17,332,731 305,100 0.40% Put option
JANE STREET GROUP, LLC $17,258,708 303,797 0.40% Shares
Impax Asset Management Group plc $17,043,000 300,000 0.40% Shares
Affinity Asset Advisors, LLC $17,043,000 300,000 0.40% Shares
NEW YORK STATE COMMON RETIREMENT FUND $16,870,127 296,957 0.39% Shares
Elmind Capital, LP $16,622,606 292,600 0.39% Shares
FIRST TRUST ADVISORS LP $16,274,815 286,478 0.38% Shares
LOOMIS SAYLES & CO L P $15,660,870 275,671 0.36% Shares
Palisades Investment Partners, LLC $15,513,675 273,080 0.36% Shares
Woodline Partners LP $14,432,808 254,054 0.33% Shares
ORBIMED ADVISORS LLC $14,372,930 253,000 0.33% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $13,896,067 244,606 0.32% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $11,676,500 205,536 0.27% Shares
F/m Investments LLC $10,656,079 187,574 0.25% Shares
HSBC HOLDINGS PLC $10,436,395 183,707 0.24% Shares
Caption Management, LLC $10,288,291 181,100 0.24% Call option
Hillsdale Investment Management Inc. $9,538,399 167,900 0.22% Shares
Palo Alto Investors LP $9,517,095 167,525 0.22% Shares
Swiss National Bank $9,464,546 166,600 0.22% Shares
MACKENZIE FINANCIAL CORP $9,462,899 166,571 0.22% Shares
ALGERT GLOBAL LLC $9,451,593 166,372 0.22% Shares
SEB Asset Management AB $9,355,055 164,673 0.22% Shares
Aquatic Capital Management LLC $8,959,505 157,710 0.21% Shares
Russell Investments Group, Ltd. $8,774,190 154,448 0.20% Shares
BlackRock, Inc. $8,640,347 152,092 0.20% Shares
Knott David M Jr $8,367,090 147,282 0.19% Shares
Voleon Capital Management LP $8,274,661 145,655 0.19% Shares
NEUBERGER BERMAN GROUP LLC $8,273,979 145,643 0.19% Shares
JANUS HENDERSON GROUP PLC $7,769,924 261,537 0.18% Shares
ESSEX INVESTMENT MANAGEMENT CO LLC $7,604,927 133,866 0.18% Shares
MORGAN STANLEY $7,526,553 132,486 0.17% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $6,779,194 119,331 0.16% Shares
Lisanti Capital Growth, LLC $6,760,674 119,005 0.16% Shares
Informed Momentum Co LLC $6,702,841 117,987 0.16% Shares
RHUMBLINE ADVISERS $6,461,781 113,744 0.15% Shares
Apis Capital Advisors, LLC $6,362,720 112,000 0.15% Shares
CITIGROUP INC $6,242,567 109,885 0.14% Shares
Squarepoint Ops LLC $6,238,136 109,807 0.14% Shares
JANE STREET GROUP, LLC $6,044,584 106,400 0.14% Call option
SILVERCREST ASSET MANAGEMENT GROUP LLC $5,920,056 104,208 0.14% Shares
CITADEL ADVISORS LLC $5,862,792 103,200 0.14% Call option
RICE HALL JAMES & ASSOCIATES, LLC $5,543,122 97,573 0.13% Shares
ExodusPoint Capital Management, LP $5,535,680 97,442 0.13% Shares
Calamos Advisors LLC $5,462,395 96,152 0.13% Shares
SummitTX Capital, L.P. $5,454,783 96,018 0.13% Shares
ALPS ADVISORS INC $5,339,061 93,981 0.12% Shares
CITADEL ADVISORS LLC $5,237,882 92,200 0.12% Put option
1832 Asset Management L.P. $5,004,961 88,100 0.12% Shares
HighVista Strategies LLC $4,898,896 86,233 0.11% Shares
MILLENNIUM MANAGEMENT LLC $4,812,546 84,713 0.11% Shares
Ishara Investments LP $4,658,420 82,000 0.11% Shares
SECTOR GAMMA AS $4,544,800 80,000 0.11% Shares
STATE OF WISCONSIN INVESTMENT BOARD $4,229,391 74,448 0.10% Shares
Quantinno Capital Management LP $4,025,727 70,863 0.09% Shares
XTX Topco Ltd $3,631,182 63,918 0.08% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $3,623,738 63,787 0.08% Shares
VANGUARD ASSET MANAGEMENT, Ltd $3,384,513 59,576 0.08% Shares

Company insiders 29 insiders · 13 officers · 13 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Eric M Dube Chief Executive Officer Sept. 5, 2023 S 242,595 0 0 $0
Christopher R. Cline Chief Financial Officer Sept. 5, 2023 S 50,574 0 0 $0
Laura Clague Chief Financial Officer May 11, 2022 S 35,655 0 0 $0
Marc L Panoff Chief Financial Officer Feb. 24, 2014 A 221,100 0 0 $0
Neil F. Mcfarlane Chief Operating Officer May 16, 2019 S 26,988 0 0 $0
Jula Inrig CHIEF MEDICAL OFFICER June 22, 2026 G 112,770 0 0 $0
Peter Heerma Chief Commercial Officer Oct. 3, 2023 S 80,257 0 0 $0
William E. Rote Senior Vice President, R&D Sept. 5, 2023 S 61,173 0 0 $0
Sandra Calvin SVP, Chief Accounting Officer May 11, 2023 S 42,247 0 0 $0
Noah L. Rosenberg Chief Medical Officer Aug. 17, 2021 S 47,614 0 0 $0
Alvin Shih EVP of Research & Development Sept. 1, 2016 S 158,334 0 0 $0
VALEUR JENSEN MARGARET E General Counsel Feb. 1, 2016 A 100,000 0 0 $0
Horacio Plotkin Chief Medical Officer Dec. 12, 2014 S 91,767 0 0 $0
Roy D. Baynes Director June 12, 2026 M 41,500 0 1 $-225,000
Timothy Coughlin Director June 12, 2026 M 56,250 0 3 $-1,272,582
LYONS GARY A Director May 19, 2026 A 61,500 0 1 $-328,560
Sandra Poole Director May 17, 2023 A 17,000 0 0 $0
Suzanne Louise Bruhn Director May 17, 2023 A 15,750 0 0 $0
Jeffery A. Meckler Director May 17, 2023 A 74,500 0 0 $0
John A Orwin Director May 17, 2023 A 22,375 0 0 $0
Ron Squarer Director May 17, 2023 A 22,375 0 0 $0
Steve Aselage Director May 11, 2022 S 146,919 0 0 $0
John W Kozarich Director May 8, 2019 A 29,000 0 0 $0
Steven Gary Richardson Director Nov. 21, 2014 P 129,165 0 0 $0
Jeffrey Paley Director Aug. 14, 2014 S 51,665 0 0 $0
Ruth Williams Brinkley May 19, 2026 A 29,750 0 0 $0
Elizabeth E Reed May 4, 2026 M 105,211 0 16 $-4,928,520
Cornelius E Golding May 18, 2016 A 29,000 0 0 $0
Martin Shkreli Sept. 12, 2014 J 1,765,168 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Opaleye L.P ×3 filings June 5, 2015 Initial filing SEC
MSMB Capital Management LP, MSMB Capital Management LLC, MSMB Healthcare LP, MSMB Healthcare Investors LLC, MSMB Healthcare Management LLC, Martin Shkreli ×2 filings Feb. 19, 2013 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 53 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
LFSC · RBB Fund, Inc. 7.67% 170,714 NS May 31, 2026 N-PORT
PJP · Invesco Exchange-Traded Fund Trust 3.52% 290,649 SH Aug. 8, 2026 Daily
SBIO · ALPS ETF Trust 2.77% 95,051 NS May 31, 2026 N-PORT
PTH · Invesco Exchange-Traded Fund Trust 2.28% 91,638 SH Aug. 8, 2026 Daily
SPIT · RBB Fund, Inc. 2.06% 14,023 NS April 30, 2026 N-PORT
BBP · ETFis Series Trust I 1.93% 27,170 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 1.33% 164,067 NS April 30, 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 1.06% 11,744 NS May 31, 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0.81% 37,788 SH Aug. 8, 2026 Daily
BRNY · EA Series Trust 0.64% 84,570 NS April 30, 2026 N-PORT
FYC · First Trust Exchange-Traded AlphaDE… 0.63% 157,219 NS April 30, 2026 N-PORT
DWAS · Invesco Exchange-Traded Fund Trust … 0.43% 31,899 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.43% 662,786 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.39% 5,059 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.34% 809,244 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.30% 95,695 SH Aug. 8, 2026 Daily
OASC · Unified Series Trust 0.28% 4,971 NS May 31, 2026 N-PORT
AFSM · First Trust Exchange-Traded Fund VI… 0.28% 5,759 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.26% 54,435 NS May 31, 2026 N-PORT
ESSC · Strategy Shares 0.25% 1,513 NS April 30, 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0.24% 70,102 NS April 30, 2026 N-PORT
BIB · ProShares Trust 0.22% 3,409 NS May 31, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.19% 32,277 NS April 30, 2026 N-PORT
ISCG · iShares Trust 0.18% 29,119 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.18% 2,265,933 SH Aug. 8, 2026 Daily
BKSE · BNY Mellon ETF Trust 0.17% 3,185 NS April 30, 2026 N-PORT
FSCC · Federated Hermes ETF Trust 0.15% 8,833 NS May 31, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.15% 514,614 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.15% 70,504 SH Aug. 8, 2026 Daily
FAD · First Trust Exchange-Traded AlphaDE… 0.13% 14,646 NS April 30, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.11% 37,027 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.11% 35,731 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.10% 3,881 NS May 31, 2026 N-PORT
FBCG · FIDELITY COVINGTON TRUST 0.09% 133,749 NS April 30, 2026 N-PORT
ISCB · iShares Trust 0.09% 4,157 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.09% 431,230 NS May 31, 2026 N-PORT
ESML · iShares Trust 0.09% 39,850 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.07% 249,426 SH Aug. 8, 2026 Daily
SMLF · iShares Trust 0.07% 46,167 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.06% 1,066,102 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.06% 3,036 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.06% 38,888 NS April 30, 2026 N-PORT
WSML · iShares Trust 0.05% 4,868 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.04% 3,073 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.02% 3,488 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.02% 77 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 26,832 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.01% 2,948,502 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 7,348 SH Aug. 8, 2026 Daily
ITOT · iShares Trust 0.01% 124,087 SH Aug. 8, 2026 Daily