SRRK Scholar Rock Holding Corporation - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$55.24
Price · Aug 19, 2026
Fundamentals as of Aug 6, 2026

SRRK Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$55.24
Market Cap
$5.99B
P/E (TTM)
-16.8
EPS (TTM)
$-3.29
Revenue (TTM)
$0
Div Yield
ROE
-157.9%
Debt/Equity
0.4
52W Range
$27 – $58

SRRK Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
6-point trend, +0.00
2018-12-31 2025-12-31
EPS $-3.29
6-point trend, -17.1%
2020-12-31 2025-12-31
Free Cash Flow $-301M
8-point trend, -1402.6%
2018-12-31 2025-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SRRK
Peer Median
P/E (TTM)
5-point trend, -93.5%
-16.8
16.0
P/B
5-point trend, +282.9%
24.4
8.5
EV / EBITDA
5-point trend, -126.8%
-14.9
Price / FCF
5-point trend, -139.9%
-19.9

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SRRK
Peer Median
ROA
5-point trend, -125.9%
-86.0%
-45.0%
ROE
5-point trend, -115.2%
-157.9%
-86.5%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SRRK
Peer Median
Debt / Equity
5-point trend, +39.8%
0.4
0.0
Current Ratio
5-point trend, +68.4%
6.9
5.8
Quick Ratio
5-point trend, +68.6%
6.6

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SRRK
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SRRK
Peer Median
EPS (Diluted)
5-point trend, +8.4%
$-3.29

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SRRK
Peer Median

SRRK Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 24 analysts
  • Strong Buy 9 37.5%
  • Buy 14 58.3%
  • Hold 1 4.2%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

16 analysts · 2026-08-18
Median target $60.00 +8.6%
Mean target $60.38 +9.3%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.05%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.84 $-0.86 0.02%
March 31, 2026 $-0.83 $-0.82 -0.01%
Dec. 31, 2025 $-0.88 $-0.91 0.03%
Sept. 30, 2025 $-0.90 $-0.86 -0.04%
June 30, 2025 $-0.98 $-0.68 -0.30%
March 31, 2025 $-0.67 $-0.67 0.00%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SRRK $4.78B -13.4 -157.9%
ORKA $1.48B -3.3 -25.9%
CGON $3.35B -20.0 254.7% -3985.0% -22.6%
MIRM $4.10B -168.1 54.7% -4.5% -8.2%
COGT $5.72B -16.4 -83.1%
CAI $7.62B -8.4 97.0% -8.4% -13.2%
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8%
ERAS $1.06B -8.5 -35.7%
TVTX $3.47B -131.8 110.5% -5.2% -34.6%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 12
Annual Income Statement data for SRRK
Metric Trend 20252024202320222021202020192018
Revenue 6-point trend, +0.00 $0 · · $33M $19M $15M $20M $0
R&D Expense 8-point trend, +474.1% $208M $185M $122M $124M $108M $74M $54M $36M
SG&A Expense 8-point trend, +1125.2% $176M $68M $49M $43M $40M $28M $21M $14M
Operating Expenses 8-point trend, +658.8% $385M $252M $171M $168M $149M $102M $75M $51M
Operating Income 8-point trend, -658.8% $-385M $-252M $-171M $-134M $-130M $-87M $-55M $-51M
Other Non-op 8-point trend, -122.0% $-301.0K $-85.0K $6M $-132.0K $-2M $395.0K $4M $1M
Net Income 8-point trend, -666.2% $-378M $-246M $-166M $-135M $-132M $-86M $-51M $-49M
EPS (Basic) 6-point trend, -17.1% $-3.29 $-2.47 $-1.99 $-2.26 $-3.59 $-2.81 · ·
EPS (Diluted) 6-point trend, -17.1% $-3.29 $-2.47 $-1.99 $-2.26 $-3.59 $-2.81 · ·
Shares (Basic) 6-point trend, +273.2% 114,701,154 99,838,102 83,347,086 59,611,656 36,711,833 30,734,109 · ·
Shares (Diluted) 6-point trend, +273.2% 114,701,154 99,838,102 83,347,086 59,611,656 36,711,833 30,734,109 · ·
EBITDA 8-point trend, -658.8% $-385M $-252M $-171M $-134M $-130M $-87M $-55M $-51M
Balance Sheet 26
Annual Balance Sheet data for SRRK
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, +181.2% $324M $178M $102M $103M $213M $160M $36M $115M
Short-term Investments 8-point trend, -27.3% $44M $259M $178M $212M $40M $181M $121M $61M
Receivables · · · · · · $25M ·
Prepaid Expense 8-point trend, +665.9% $18M $14M $8M $13M $12M $3M $3M $2M
Current Assets 8-point trend, +116.4% $385M $451M $288M $328M $265M $344M $185M $178M
PP&E (Net) 8-point trend, -46.6% $2M $3M $5M $7M $10M $8M $4M $3M
PP&E (Gross) 8-point trend, +199.0% $17M $16M $16M $18M $17M $13M $8M $6M
Accum. Depreciation 8-point trend, +531.4% $15M $13M $11M $10M $7M $5M $4M $2M
Other Non-current Assets 7-point trend, +3196.9% $3M $3M $4M $2M $2M $1M $98.0K ·
Total Assets 8-point trend, +122.9% $404M $475M $311M $358M $304M $388M $196M $181M
Accounts Payable 8-point trend, +211.9% $10M $10M $3M $4M $4M $3M $1M $3M
Accrued Liabilities 8-point trend, +452.8% $40M $31M $20M $24M $17M $15M $10M $7M
Short-term Debt 2-point trend, -15.4% · · $1M · $2M · · ·
Current Liabilities 8-point trend, +78.1% $55M $47M $33M $36M $64M $43M $33M $31M
Capital Leases 7-point trend, -12.3% $4M $9M $4M $12M $20M $27M $4M ·
Other Non-current Liabilities 2-point trend, -44.4% · · · · · $5.0K $9.0K ·
Total Liabilities 8-point trend, +112.5% $159M $106M $86M $98M $132M $128M $83M $75M
Long-term Debt 4-point trend, +96.2% · · $51M $51M $52M $26M · ·
Total Debt 6-point trend, +304.0% $100M $50M $50M $50M $50M $25M · ·
Common Stock 8-point trend, +315.4% $108.0K $94.0K $76.0K $52.0K $35.0K $34.0K $30.0K $26.0K
Paid-in Capital 8-point trend, +624.3% $1.55B $1.29B $901M $772M $548M $505M $271M $213M
Retained Earnings 8-point trend, -1117.3% $-1.30B $-923M $-676M $-511M $-376M $-244M $-158M $-107M
AOCI 8-point trend, +1275.0% $94.0K $160.0K $92.0K $-884.0K $-35.0K $-2.0K $37.0K $-8.0K
Stockholders' Equity 8-point trend, +130.2% $245M $369M $225M $260M $172M $261M $113M $107M
Liabilities + Equity 8-point trend, +122.9% $404M $475M $311M $358M $304M $388M $196M $181M
Shares Outstanding 8-point trend, +313.7% 108,461,354 93,823,678 75,979,495 51,672,579 35,209,099 34,152,470 29,792,922 26,217,701
Cash Flow 13
Annual Cash Flow data for SRRK
Metric Trend 20252024202320222021202020192018
D&A 8-point trend, +107.2% $2M $2M $3M $3M $3M $1M $1M $800.0K
Stock-based Comp 8-point trend, +1350.8% $76M $37M $27M $28M $23M $11M $8M $5M
Operating Cash Flow 8-point trend, -1321.1% $-300M $-201M $-145M $-133M $-127M $-60M $-63M $25M
CapEx 8-point trend, -59.7% $602.0K $98.0K $71.0K $1M $5M $4M $3M $1M
Investing Cash Flow 8-point trend, +463.1% $219M $-76M $41M $-172M $134M $-63M $-62M $-60M
Debt Issued $25M · · · · · · ·
Net Debt Issued $-852.0K · · · · · · ·
Stock Issued 8-point trend, -3.4% $92M $324M $98M $195M $13M $216M $48M $95M
Net Stock Activity 8-point trend, +436.1% $92M $324M $98M $195M $13M $216M $48M $17M
Financing Cash Flow 8-point trend, +142.3% $228M $353M $103M $195M $45M $248M $49M $94M
Net Change in Cash 7-point trend, +29.7% · $76M $-2M $-110M $52M $124M $-76M $59M
Taxes Paid $46.0K · · · · · · ·
Free Cash Flow 8-point trend, -1402.6% $-301M $-201M $-145M $-134M $-132M $-64M $-66M $23M
Profitability 5
Annual Profitability data for SRRK
Metric Trend 20252024202320222021202020192018
Operating Margin 4-point trend, -52.1% · · · -404.8% -690.5% -564.0% -266.2% ·
Net Margin 4-point trend, -62.8% · · · -405.2% -700.5% -561.5% -248.9% ·
EBITDA Margin 4-point trend, -52.1% · · · -404.8% -690.5% -564.0% -266.2% ·
ROA 8-point trend, -111.7% -86.0% -62.7% -49.5% -40.6% -38.0% -29.6% -27.0% -40.6%
ROE 8-point trend, -234.4% -157.9% -110.0% -84.4% -48.6% -73.4% -53.4% -43.5% -47.2%
Liquidity & Solvency 4
Annual Liquidity & Solvency data for SRRK
Metric Trend 20252024202320222021202020192018
Current Ratio 8-point trend, +21.6% 6.9 9.6 8.8 9.0 4.1 8.1 5.6 5.7
Quick Ratio 8-point trend, +17.5% 6.6 9.3 8.6 8.7 3.9 8.0 5.6 5.6
Debt / Equity 6-point trend, +329.4% 0.4 0.1 0.2 0.2 0.3 0.1 · ·
LT Debt / Equity 6-point trend, +329.4% 0.4 0.1 0.2 0.2 0.3 0.1 · ·
Efficiency 2
Annual Efficiency data for SRRK
Metric Trend 20252024202320222021202020192018
Asset Turnover 6-point trend, +0.00 0.0 · · 0.1 0.1 0.1 0.1 0.0
Receivables Turnover · · · · · · 1.6 ·
Per Share 5
Annual Per Share data for SRRK
Metric Trend 20252024202320222021202020192018
Book Value / Share 8-point trend, -44.3% $2.26 $3.93 $2.96 $5.04 $4.89 $7.64 $3.79 $4.07
Revenue / Share 3-point trend, -100.0% $0.00 · · $0.56 $0.51 · · ·
Cash Flow / Share 5-point trend, +24.3% $-2.62 $-2.01 $-1.74 $-2.23 $-3.45 · · ·
Cash / Share 8-point trend, -32.0% $2.98 $1.90 $1.34 $2.00 $6.04 $4.70 $1.22 $4.39
EPS (TTM) 6-point trend, -17.1% $-3.29 $-2.47 $-1.99 $-2.26 $-3.59 $-2.81 · ·
Growth Rates 1
Annual Growth Rates data for SRRK
Metric Trend 20252024202320222021202020192018
Revenue YoY 2-point trend, +244.8% · · · 76.4% 22.2% · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for SRRK
Metric Trend 20252024202320222021202020192018
Revenue TTM 8-point trend, +0.00 $0 $48M $48M $33M $19M $15M $20M $0
Net Income TTM 8-point trend, -666.2% $-378M $-246M $-166M $-135M $-132M $-86M $-51M $-49M
Market Cap 8-point trend, +693.4% $4.78B $4.06B $1.43B $468M $875M $1.66B $393M $602M
Enterprise Value 6-point trend, +236.3% $4.51B $3.67B $1.20B $202M $672M $1.34B · ·
P/E 6-point trend, +22.5% -13.4 -17.5 -9.4 -4.0 -6.9 -17.3 · ·
P/S 6-point trend, +341.2% · 84.6 29.8 14.1 46.5 107.6 19.2 ·
P/B 8-point trend, +244.6% 19.5 11.0 6.3 1.8 5.1 6.4 3.5 5.6
P / Tangible Book 6-point trend, +206.2% 19.5 11.0 6.3 1.8 5.1 6.4 · ·
P / Cash Flow 8-point trend, -165.0% -15.9 -20.2 -9.8 -3.5 -6.9 -27.5 -6.2 24.5
P / FCF 8-point trend, -160.9% -15.9 -20.2 -9.8 -3.5 -6.6 -25.8 -5.9 26.1
EV / EBITDA 6-point trend, +24.0% -11.7 -14.6 -7.0 -1.5 -5.2 -15.4 · ·
EV / FCF 6-point trend, +28.0% -15.0 -18.2 -8.2 -1.5 -5.1 -20.8 · ·
EV / Revenue 5-point trend, -12.2% · 76.5 25.0 6.1 35.7 87.1 · ·
Earnings Yield 6-point trend, -29.0% -7.5% -5.7% -10.6% -25.0% -14.4% -5.8% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0$33M$19M
Operating Margin % -404.8%-690.5%
Net Income $-378M$-246M$-166M$-135M$-132M
Diluted EPS $-3.29$-2.47$-1.99$-2.26$-3.59
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.40.10.20.20.3
Current Ratio 6.99.68.89.04.1
Quick Ratio 6.69.38.68.73.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-301M$-201M$-145M$-134M$-132M

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Institutional owners (13F) 327 filers · $5.2B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
61 (+18 vs prior Q) 22 (-12 vs prior Q) 118 (+7 vs prior Q) 85 (+8 vs prior Q) +5.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $625,711,735 11,376,577 12.02% Shares
Siren, L.L.C. $526,625,715 9,575,013 10.12% Shares
SAMSARA BIOCAPITAL, LLC $379,370,860 6,897,652 7.29% Shares
WELLINGTON MANAGEMENT GROUP LLP $320,613,590 5,829,338 6.16% Shares
VANGUARD CAPITAL MANAGEMENT LLC $262,233,400 4,767,880 5.04% Shares
STATE STREET CORP $260,077,455 4,728,681 5.00% Shares
Redmile Group, LLC $237,110,060 4,311,092 4.56% Shares
NORGES BANK $152,345,050 2,769,910 2.93% Shares
GEODE CAPITAL MANAGEMENT, LLC $130,314,874 2,368,811 2.50% Shares
Hood River Capital Management LLC $122,363,340 2,224,788 2.35% Shares
Driehaus Capital Management LLC $121,308,990 2,205,618 2.33% Shares
EVENTIDE ASSET MANAGEMENT, LLC $116,126,838 2,111,410 2.23% Shares
JANUS HENDERSON GROUP PLC $108,218,139 2,202,774 2.08% Shares
Polar Capital Holdings Plc $103,321,900 1,878,580 1.99% Shares
JENNISON ASSOCIATES LLC $102,381,235 1,861,477 1.97% Shares
Holocene Advisors, LP $96,578,790 1,755,978 1.86% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $95,227,110 1,731,402 1.83% Shares
Woodline Partners LP $82,525,850 1,500,470 1.59% Shares
GOLDMAN SACHS GROUP INC $65,846,495 1,197,209 1.27% Shares
Capital World Investors $63,822,495 1,160,409 1.23% Shares
Clearbridge Investments, LLC $58,287,699 1,059,776 1.12% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $56,504,635 1,027,357 1.09% Shares
AMERICAN CENTURY COMPANIES INC $53,635,955 975,197 1.03% Shares
Pictet Asset Management Holding SA $50,106,164 911,075 0.96% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $47,535,730 864,286 0.91% Shares
BANK OF AMERICA CORP /DE/ $41,877,440 761,408 0.80% Shares
Integral Health Asset Management, LLC $41,250,000 750,000 0.79% Shares
FEDERATED HERMES, INC. $40,398,215 734,513 0.78% Shares
VANGUARD FIDUCIARY TRUST CO $40,154,565 730,083 0.77% Shares
BNP PARIBAS FINANCIAL MARKETS $39,463,160 717,512 0.76% Shares
Rock Springs Capital Management LP $39,349,860 715,452 0.76% Shares
Casdin Capital, LLC $36,575,000 665,000 0.70% Shares
Ensign Peak Advisors, Inc $31,847,860 579,052 0.61% Shares
Eagle Health Investments LP $30,539,960 555,272 0.59% Shares
LOOMIS SAYLES & CO L P $27,261,630 495,666 0.52% Shares
Qube Research & Technologies Ltd $25,505,150 463,730 0.49% Shares
VANGUARD GROUP INC $25,434,426 577,399 0.49% Shares
Fisher Asset Management, LLC $24,169,585 439,447 0.46% Shares
CITADEL ADVISORS LLC $18,251,805 331,851 0.35% Shares
Squarepoint Ops LLC $16,059,780 291,996 0.31% Shares
NAN FUNG TRINITY (HK) LTD $15,702,225 285,495 0.30% Shares
ARMISTICE CAPITAL, LLC $15,290,000 278,000 0.29% Shares
Trexquant Investment LP $15,164,160 275,712 0.29% Shares
First Turn Management, LLC $14,917,485 271,227 0.29% Shares
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $14,316,555 260,301 0.28% Shares
STEMPOINT CAPITAL LP $13,153,030 239,146 0.25% Shares
Candriam S.C.A. $11,876,592 216,146 0.23% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $11,549,505 209,991 0.22% Shares
Logos Global Management LP $11,000,000 200,000 0.21% Shares
Susquehanna Portfolio Strategies, LLC $10,947,860 199,052 0.21% Shares
SEGALL BRYANT & HAMILL, LLC $10,372,340 188,588 0.20% Shares
Granahan Investment Management, LLC $9,006,745 163,759 0.17% Shares
VOYA INVESTMENT MANAGEMENT LLC $8,986,175 163,385 0.17% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $8,888,000 161,600 0.17% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $8,624,000 156,800 0.17% Call option
Swiss National Bank $8,239,000 149,800 0.16% Shares
RHUMBLINE ADVISERS $8,000,300 145,460 0.15% Shares
PEREGRINE CAPITAL MANAGEMENT LLC $7,674,370 139,534 0.15% Shares
GordonMD Global Investments LP $7,287,500 132,500 0.14% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $6,972,185 126,767 0.13% Shares
MGO ONE SEVEN LLC $6,879,235 125,077 0.13% Shares
ALLIANCEBERNSTEIN L.P. $6,873,551 139,820 0.13% Shares
AMERIPRISE FINANCIAL INC $6,837,380 124,316 0.13% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $6,722,265 122,223 0.13% Shares
TD Asset Management Inc $6,620,020 120,364 0.13% Shares
BlackRock, Inc. $6,156,700 111,940 0.12% Shares
CITIGROUP INC $5,854,310 106,442 0.11% Shares
Man Group plc $5,739,030 104,346 0.11% Shares
CITADEL ADVISORS LLC $5,566,000 101,200 0.11% Put option
Ghisallo Capital Management LLC $5,500,000 100,000 0.11% Shares
Artia Global Partners LP $5,295,675 96,285 0.10% Shares
SPHERA FUNDS MANAGEMENT LTD. $5,184,575 94,265 0.10% Shares
RENAISSANCE TECHNOLOGIES LLC $5,032,500 91,500 0.10% Shares
D. E. Shaw & Co., Inc. $5,007,145 91,039 0.10% Shares
FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. $5,005,990 91,018 0.10% Shares
Nicholas Investment Partners, LP $4,968,370 90,334 0.10% Shares
AXA Investment Managers S.A. $4,936,907 132,570 0.09% Shares
BEACONLIGHT CAPITAL, LLC $4,834,115 87,893 0.09% Shares
RAYMOND JAMES FINANCIAL INC $4,622,805 84,051 0.09% Shares
VANGUARD ASSET MANAGEMENT, Ltd $4,385,535 79,737 0.08% Shares
StoneCrest Wealth Management, Inc. $4,332,900 78,780 0.08% Shares
Aisling Capital Management LP $4,236,705 77,031 0.08% Shares
Hudson Bay Capital Management LP $4,125,000 75,000 0.08% Shares
Cinctive Capital Management LP $3,954,995 71,909 0.08% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3,682,871 74,916 0.07% Shares
MetLife Investment Management, LLC $3,577,090 65,038 0.07% Shares
Rafferty Asset Management, LLC $3,443,440 62,608 0.07% Shares
EFG Asset Management (North America) Corp. $3,278,865 88,106 0.06% Shares
ALGERT GLOBAL LLC $3,209,250 58,350 0.06% Shares
POLEN CAPITAL MANAGEMENT LLC $2,867,260 52,132 0.06% Shares
DEUTSCHE BANK AG\ $2,814,955 51,181 0.05% Shares
NEW YORK STATE COMMON RETIREMENT FUND $2,801,315 50,933 0.05% Shares
JANE STREET GROUP, LLC $2,695,000 49,000 0.05% Put option
Moody Aldrich Partners LLC $2,597,540 47,228 0.05% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $2,533,000 46,054 0.05% Shares
KVP Capital Advisors, LP $2,475,000 45,000 0.05% Shares
Invesco Ltd. $2,431,770 44,214 0.05% Shares
STATE OF WISCONSIN INVESTMENT BOARD $2,366,100 43,020 0.05% Shares
Vanguard Global Advisers, LLC $2,356,750 42,850 0.05% Shares
Jasper Ridge Partners, L.P. $2,335,025 42,455 0.04% Shares

Company insiders 28 insiders · 19 officers · 11 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
David Hallal Chief Executive Officer April 16, 2026 S 1,639,034 0 2 $-3,970,701
Jay T. Backstrom CEO-Elect Sept. 20, 2022 A 0 0 $0
Nagesh K. Manhathappa Interim CEO and President June 16, 2022 A 480,491 0 0 $0
Stuart A Kingsley President and CEO Feb. 1, 2021 A 42,000 0 0 $0
Vikas Sinha Chief Financial Officer April 16, 2026 S 619,856 0 2 $-1,231,462
Edward H Myles COO & CFO March 10, 2025 M 111,345 0 0 $0
Rhonda M. Chicko Chief Financial Officer Jan. 31, 2019 A 0 0 $0
Akshay Vaishnaw President of R&D April 16, 2026 S 630,542 0 2 $-1,479,737
Keith Woods Chief Operating Officer April 16, 2026 S 620,055 0 2 $-1,221,659
Elan Ezickson COO & Head of Corp.Development May 29, 2018 A 0 0 $0
Mo Qatanani CHIEF SCIENTIFIC OFFICER Feb. 23, 2026 S 98,445 0 3 $-399,335
Caryn Parlavecchio Chief Human Resources Officer Feb. 9, 2026 A 178,122 0 0 $0
Junlin Ho General Counsel Feb. 9, 2026 A 251,125 0 0 $0
Jing L. Marantz Chief Medical Officer Feb. 9, 2026 A 130,169 0 0 $0
Tracey Sacco Chief Commercial Officer April 25, 2025 M 71,750 0 0 $0
Gregory John Carven Chief Scientific Officer June 16, 2022 A 128,208 0 0 $0
Yung H. Chyung Chief Medical Officer Feb. 14, 2022 A 258,496 0 0 $0
Erin Moore SVP, Finance Feb. 6, 2020 A 0 0 $0
Alan J. Buckler Chief Scientific Officer Feb. 6, 2020 A 0 0 $0
Katie Peng Director July 1, 2026 S 34,301 0 3 $-293,398
Joshua Reed Director July 1, 2026 S 19,518 0 2 $-164,075
Jeffrey S. Flier Director July 1, 2026 S 27,856 0 3 $-164,491
Kristina Burow Director July 1, 2026 S 114,657 0 2 $-164,053
Michael Gilman Director July 1, 2026 S 59,511 0 3 $-137,058
Richard Brudnick Director June 4, 2026 A 21,896 0 0 $0
Srinivas Akkaraju Director June 4, 2026 A 27,971 9 0 $19,988,986
Amir Nashat Director May 9, 2024 J 38,639 0 0 $0
Timothy A. Springer 10% owner Dec. 10, 2019 G 2,376,567 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Samsara BioCapital, L.P., Samsara BioCapital GP, LLC, Samsara Opportunity Fund, L.P., Samsara Opportunity Fund GP, LLC, Srinivas Akkaraju ×4 filings Oct. 7, 2025 7.20% Amendment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 46 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBRN · iShares Trust 4.53% 6,638 SH Aug. 8, 2026 Daily
GURU · Global X Funds 1.08% 13,555 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 1.01% 112,425 NS April 30, 2026 N-PORT
HRTS · Tema ETF Trust 0.92% 9,647 NS May 31, 2026 N-PORT
BBC · ETFis Series Trust I 0.74% 5,888 NS April 30, 2026 N-PORT
MEDI · Harbor ETF Trust 0.57% 3,384 NS April 30, 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0.45% 4,801 NS May 31, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.43% 6,524 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.39% 706,904 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.34% 954,046 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.34% 112,682 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.25% 3,773 NS May 31, 2026 N-PORT
ESSC · Strategy Shares 0.24% 1,335 NS April 30, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.20% 31,295 NS April 30, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.19% 643,358 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.18% 2,827,782 SH Aug. 8, 2026 Daily
BKSE · BNY Mellon ETF Trust 0.15% 2,527 NS April 30, 2026 N-PORT
RSSL · Global X Funds 0.12% 37,817 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.11% 4,109 NS May 31, 2026 N-PORT
ISCV · iShares Trust 0.10% 12,994 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.09% 406,966 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.07% 3,926 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.06% 3,213 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.06% 1,141,089 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.06% 224,721 SH Aug. 8, 2026 Daily
FBCG · FIDELITY COVINGTON TRUST 0.06% 78,058 NS April 30, 2026 N-PORT
ESML · iShares Trust 0.05% 28,295 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.05% 27,110 SH Aug. 8, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.05% 28,968 NS April 30, 2026 N-PORT
ISCG · iShares Trust 0.05% 8,820 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.05% 3,252 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.03% 4,310 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.02% 59,002 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.02% 3,203 NS May 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.02% 7,030 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 5,664 SH Aug. 8, 2026 Daily
HDG · ProShares Trust 0.02% 82 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 29,191 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.01% 3,428,276 SH Aug. 8, 2026 Daily
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0.01% 89,618 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 9,206 SH Aug. 8, 2026 Daily
ESGV · VANGUARD WORLD FUND 0.01% 24,696 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.01% 29,642 SH Aug. 8, 2026 Daily
TILT · FlexShares Trust 0.01% 3,234 NS April 30, 2026 N-PORT
ITOT · iShares Trust 0.01% 134,638 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.01% 49,047 NS May 31, 2026 N-PORT