SRRK Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $46.81
Market Cap (MRQ) $5.69B
P/E (TTM) -14.1
EPS (TTM) $-3.31
Revenue (TTM) $0
ROE (TTM) -167.8%
Debt/Equity (MRQ) 0.8
52W Range $27–$62

SRRK Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
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10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$0
2018-12-31 → 2025-12-31
EPS$-3.29
2020-12-31 → 2025-12-31
Free Cash Flow$-301M
2018-12-31 → 2025-12-31
Net margin·
2019-12-31 → 2022-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend SRRK 5Y avg Peer Median Verdict
P/E (TTM) -14.15Y avg ≈-10.3 ≈-10.3 · ·
P/B (MRQ) 22.45Y avg ≈8.7 ≈8.7 11.6 Overvalued
EV / EBITDA -12.55Y avg ≈-8.0 ≈-8.0 · ·
Price / FCF (TTM) -19.25Y avg ≈-11.2 ≈-11.2 · ·
Price / Cash Flow (TTM) -19.25Y avg ≈-11.3 ≈-11.3 · ·
EV / FCF (TTM) -18.25Y avg ≈-9.6 ≈-9.6 · ·
Price / Tangible Book 20.75Y avg ≈8.7 ≈8.7 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -7.6%
Next Report Nov 12, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 12, 2026 $-0.84 $-0.86 2.0%
March 31, 2026 May 12, 2026 $-0.83 $-0.82 -1.6%
Dec. 31, 2025 $-0.88 $-0.91 3.1%
Sept. 30, 2025 $-0.90 $-0.86 -5.2%
June 30, 2025 $-0.98 $-0.68 -44.6%
March 31, 2025 $-0.67 $-0.67 0.64%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 12
Metric Trend 20252024202320222021202020192018
Revenue $0··$33M$19M$15M$20M$0
R&D Expense $208M$185M$122M$124M$108M$74M$54M$36M
SG&A Expense $176M$68M$49M$43M$40M$28M$21M$14M
Operating Expenses $385M$252M$171M$168M$149M$102M$75M$51M
Operating Income $-385M$-252M$-171M$-134M$-130M$-87M$-55M$-51M
Other Non-op $-301.0K$-85.0K$6M$-132.0K$-2M$395.0K$4M$1M
Net Income $-378M$-246M$-166M$-135M$-132M$-86M$-51M$-49M
EPS (Basic) $-3.29$-2.47$-1.99$-2.26$-3.59$-2.81··
EPS (Diluted) $-3.29$-2.47$-1.99$-2.26$-3.59$-2.81··
Shares (Basic) 114,701,15499,838,10283,347,08659,611,65636,711,83330,734,109··
Shares (Diluted) 114,701,15499,838,10283,347,08659,611,65636,711,83330,734,109··
EBITDA $-385M$-252M$-171M$-134M$-130M$-87M$-55M$-51M
Balance Sheet 26
Metric Trend 20252024202320222021202020192018
Cash & Equivalents $324M$178M$102M$103M$213M$160M$36M$115M
Short-term Investments $44M$259M$178M$212M$40M$181M$121M$61M
Receivables ······$25M·
Prepaid Expense $18M$14M$8M$13M$12M$3M$3M$2M
Current Assets $385M$451M$288M$328M$265M$344M$185M$178M
PP&E (Net) $2M$3M$5M$7M$10M$8M$4M$3M
PP&E (Gross) $17M$16M$16M$18M$17M$13M$8M$6M
Accum. Depreciation $15M$13M$11M$10M$7M$5M$4M$2M
Other Non-current Assets $3M$3M$4M$2M$2M$1M$98.0K·
Total Assets $404M$475M$311M$358M$304M$388M$196M$181M
Accounts Payable $10M$10M$3M$4M$4M$3M$1M$3M
Accrued Liabilities $40M$31M$20M$24M$17M$15M$10M$7M
Short-term Debt ··$1M·$2M···
Current Liabilities $55M$47M$33M$36M$64M$43M$33M$31M
Capital Leases $4M$9M$4M$12M$20M$27M$4M·
Other Non-current Liabilities ·····$5.0K$9.0K·
Total Liabilities $159M$106M$86M$98M$132M$128M$83M$75M
Long-term Debt ··$51M$51M$52M$26M··
Total Debt $100M$50M$50M$50M$50M$25M··
Common Stock $108.0K$94.0K$76.0K$52.0K$35.0K$34.0K$30.0K$26.0K
Paid-in Capital $1.55B$1.29B$901M$772M$548M$505M$271M$213M
Retained Earnings $-1.30B$-923M$-676M$-511M$-376M$-244M$-158M$-107M
AOCI $94.0K$160.0K$92.0K$-884.0K$-35.0K$-2.0K$37.0K$-8.0K
Stockholders' Equity $245M$369M$225M$260M$172M$261M$113M$107M
Liabilities + Equity $404M$475M$311M$358M$304M$388M$196M$181M
Shares Outstanding 108,461,35493,823,67875,979,49551,672,57935,209,09934,152,47029,792,92226,217,701
Cash Flow 13
Metric Trend 20252024202320222021202020192018
D&A $2M$2M$3M$3M$3M$1M$1M$800.0K
Stock-based Comp $76M$37M$27M$28M$23M$11M$8M$5M
Operating Cash Flow $-300M$-201M$-145M$-133M$-127M$-60M$-63M$25M
CapEx $602.0K$98.0K$71.0K$1M$5M$4M$3M$1M
Investing Cash Flow $219M$-76M$41M$-172M$134M$-63M$-62M$-60M
Debt Issued $25M·······
Net Debt Issued $-852.0K·······
Stock Issued $92M$324M$98M$195M$13M$216M$48M$95M
Net Stock Activity $92M$324M$98M$195M$13M$216M$48M$17M
Financing Cash Flow $228M$353M$103M$195M$45M$248M$49M$94M
Net Change in Cash ·$76M$-2M$-110M$52M$124M$-76M$59M
Taxes Paid $46.0K·······
Free Cash Flow $-301M$-201M$-145M$-134M$-132M$-64M$-66M$23M
Profitability 5
Metric Trend 20252024202320222021202020192018
Operating Margin ···-404.8%-690.5%-564.0%-266.2%·
Net Margin ···-405.2%-700.5%-561.5%-248.9%·
EBITDA Margin ···-404.8%-690.5%-564.0%-266.2%·
ROA -86.0%-62.7%-49.5%-40.6%-38.0%-29.6%-27.0%-40.6%
ROE -157.9%-110.0%-84.4%-48.6%-73.4%-53.4%-43.5%-47.2%
Liquidity & Solvency 4
Metric Trend 20252024202320222021202020192018
Current Ratio 6.99.68.89.04.18.15.65.7
Quick Ratio 6.69.38.68.73.98.05.65.6
Debt / Equity 0.40.10.20.20.30.1··
LT Debt / Equity 0.40.10.20.20.30.1··
Efficiency 2
Metric Trend 20252024202320222021202020192018
Asset Turnover 0.0··0.10.10.10.10.0
Receivables Turnover ······1.6·
Per Share 5
Metric Trend 20252024202320222021202020192018
Book Value / Share $2.26$3.93$2.96$5.04$4.89$7.64$3.79$4.07
Revenue / Share $0.00··$0.56$0.51···
Cash Flow / Share $-2.62$-2.01$-1.74$-2.23$-3.45···
Cash / Share $2.98$1.90$1.34$2.00$6.04$4.70$1.22$4.39
EPS (TTM) $-3.29$-2.47$-1.99$-2.26$-3.59$-2.81··
Growth Rates 1
Metric Trend 20252024202320222021202020192018
Revenue YoY ···76.4%22.2%···
Valuation (TTM) 14
Metric Trend 20252024202320222021202020192018
Revenue TTM $0$48M$48M$33M$19M$15M$20M$0
Net Income TTM $-378M$-246M$-166M$-135M$-132M$-86M$-51M$-49M
Market Cap $4.78B$4.06B$1.43B$468M$875M$1.66B$393M$602M
Enterprise Value $4.51B$3.67B$1.20B$202M$672M$1.34B··
P/E -13.4-17.5-9.4-4.0-6.9-17.3··
P/S ·84.629.814.146.5107.619.2·
P/B 19.511.06.31.85.16.43.55.6
P / Tangible Book 19.511.06.31.85.16.4··
P / Cash Flow -15.9-20.2-9.8-3.5-6.9-27.5-6.224.5
P / FCF -15.9-20.2-9.8-3.5-6.6-25.8-5.926.1
EV / EBITDA -11.7-14.6-7.0-1.5-5.2-15.4··
EV / FCF -15.0-18.2-8.2-1.5-5.1-20.8··
EV / Revenue ·76.525.06.135.787.1··
Earnings Yield -7.5%-5.7%-10.6%-25.0%-14.4%-5.8%··

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0 · · $33M $19M
Operating Margin % · · · -404.8% -690.5%
Net Income $-378M $-246M $-166M $-135M $-132M
Diluted EPS $-3.29 $-2.47 $-1.99 $-2.26 $-3.59

Institutional owners (13F) 326 filers · $7.5B total · As of Sept. 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 326
Value held $7.5B
New positions 54
Exited positions 22
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
54 (+4 vs prior Q) 22 (-12 vs prior Q) 130 (+17 vs prior Q) 83 (+3 vs prior Q) +2.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $989,738,234 17,995,241 13.22% Shares
Siren, L.L.C. $526,625,715 9,575,013 7.03% Shares
BlackRock, Inc. $522,174,620 9,494,084 6.97% Shares
SAMSARA BIOCAPITAL, LLC $379,370,860 6,897,652 5.07% Shares
WELLINGTON MANAGEMENT GROUP LLP $369,989,675 6,727,085 4.94% Shares
Orbis Allan Gray Ltd $326,344,315 5,933,533 4.36% Shares
VANGUARD CAPITAL MANAGEMENT LLC $262,233,400 4,767,880 3.50% Shares
STATE STREET CORP $260,077,455 4,728,681 3.47% Shares
Redmile Group, LLC $237,110,060 4,311,092 3.17% Shares
VANGUARD GROUP INC $228,860,234 5,195,465 3.06% Shares
NORGES BANK $152,345,050 2,769,910 2.03% Shares
GEODE CAPITAL MANAGEMENT, LLC $151,488,554 2,753,787 2.02% Shares
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $143,393,380 2,607,348 1.92% Shares
Bellevue Group AG $134,725,085 2,449,547 1.80% Shares
JENNISON ASSOCIATES LLC $129,722,285 2,358,587 1.73% Shares
Hood River Capital Management LLC $122,363,340 2,224,788 1.63% Shares
Driehaus Capital Management LLC $121,308,990 2,205,618 1.62% Shares
EVENTIDE ASSET MANAGEMENT, LLC $116,126,838 2,111,410 1.55% Shares
JANUS HENDERSON GROUP PLC $109,890,973 2,236,837 1.47% Shares
Polar Capital Holdings Plc $103,321,900 1,878,580 1.38% Shares
Holocene Advisors, LP $96,578,790 1,755,978 1.29% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $95,227,110 1,731,402 1.27% Shares
MORGAN STANLEY $84,632,717 1,538,776 1.13% Shares
Woodline Partners LP $82,525,850 1,500,470 1.10% Shares
GOLDMAN SACHS GROUP INC $77,631,235 1,411,477 1.04% Shares
Capital World Investors $63,822,495 1,160,409 0.85% Shares
Clearbridge Investments, LLC $58,287,699 1,059,776 0.78% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $56,504,635 1,027,357 0.75% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $53,891,475 979,845 0.72% Shares
AMERICAN CENTURY COMPANIES INC $53,635,955 975,197 0.72% Shares
NORTHERN TRUST CORP $53,601,680 974,576 0.72% Shares
BANK OF AMERICA CORP /DE/ $53,474,135 972,257 0.71% Shares
Pictet Asset Management Holding SA $50,106,164 911,075 0.67% Shares
VOYA INVESTMENT MANAGEMENT LLC $48,983,385 890,607 0.65% Shares
FRANKLIN RESOURCES INC $48,329,930 878,726 0.65% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $47,535,730 864,286 0.63% Shares
Integral Health Asset Management, LLC $41,250,000 750,000 0.55% Shares
FEDERATED HERMES, INC. $40,398,215 734,513 0.54% Shares
VANGUARD FIDUCIARY TRUST CO $40,154,565 730,083 0.54% Shares
BNP PARIBAS FINANCIAL MARKETS $39,463,160 717,512 0.53% Shares
Rock Springs Capital Management LP $39,349,860 715,452 0.53% Shares
Casdin Capital, LLC $36,575,000 665,000 0.49% Shares
Nuveen, LLC $35,846,195 651,749 0.48% Shares
LOOMIS SAYLES & CO L P $32,783,025 596,055 0.44% Shares
Ensign Peak Advisors, Inc $31,847,860 579,052 0.43% Shares
Eagle Health Investments LP $30,539,960 555,272 0.41% Shares
UBS Group AG $28,114,350 511,170 0.38% Shares
Qube Research & Technologies Ltd $25,505,150 463,730 0.34% Shares
Fisher Asset Management, LLC $24,169,585 439,447 0.32% Shares
MARSHALL WACE, LLP $23,677,500 430,500 0.32% Shares

Show all 326 institutional owners →

Activists & 5%+ owners 1 position

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Samsara BioCapital, L.P., Samsara BioCapital GP, LLC, Samsara Opportunity Fund, L.P., Samsara Opportunity Fund GP, LLC, Srinivas Akkaraju ×4 filings Oct. 7, 2025 7.20% Amendment · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 28 insiders · 19 officers · 12 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
David Hallal Chief Executive Officer Sept. 21, 2026 G 1,602,382 0 2 $-3,970,701
Jay T. Backstrom CHIEF EXECUTIVE OFFICER March 10, 2025 A 425,561 0 0 $0
Nagesh K. Manhathappa Interim CEO and President June 16, 2022 A 480,491 0 0 $0
Stuart A Kingsley President and CEO Feb. 1, 2021 A 42,000 0 0 $0
Vikas Sinha Chief Financial Officer April 16, 2026 S 619,856 0 2 $-1,231,462
Edward H Myles COO & CFO March 10, 2025 M 111,345 0 0 $0
Rhonda M. Chicko Chief Financial Officer Jan. 31, 2019 A · 0 0 $0
Akshay Vaishnaw President of R&D April 16, 2026 S 630,542 0 2 $-1,479,737
Keith Woods Chief Operating Officer Sept. 24, 2026 G 572,021 0 2 $-1,221,659
Elan Ezickson COO & Head of Corp.Development May 29, 2018 A · 0 0 $0
Mo Qatanani CHIEF SCIENTIFIC OFFICER Feb. 23, 2026 S 98,445 0 9 $-8,602,966
Caryn Parlavecchio CHRO Feb. 17, 2026 S 169,087 0 2 $-713,967
Junlin Ho GENERAL COUNSEL Feb. 17, 2026 S 241,545 0 2 $-802,309
Jing L. Marantz CHIEF MEDICAL OFFICER Feb. 17, 2026 S 126,012 0 2 $-451,320
Tracey Sacco Chief Commercial Officer April 25, 2025 M 71,750 0 0 $0
Erin Moore Interim PFO and PAO March 24, 2025 M 82,609 0 0 $0
Gregory John Carven Chief Scientific Officer June 16, 2022 A 128,208 0 0 $0
Yung H. Chyung Chief Medical Officer Feb. 14, 2022 A 258,496 0 0 $0
Alan J. Buckler Chief Scientific Officer Feb. 6, 2020 A · 0 0 $0
Katie Peng Director July 1, 2026 S 34,301 0 5 $-337,751
Joshua Reed Director July 1, 2026 S 19,518 0 2 $-164,075
Jeffrey S. Flier Director July 1, 2026 S 27,856 0 3 $-164,491
Kristina Burow Director July 1, 2026 S 114,657 0 2 $-164,053
Michael Gilman Director July 1, 2026 S 59,511 0 3 $-137,058
Richard Brudnick Director June 4, 2026 A 21,896 0 0 $0
Srinivas Akkaraju Director June 4, 2026 A 27,971 9 0 $19,988,986
Amir Nashat Director May 9, 2024 J 38,639 0 0 $0
Timothy A. Springer 10% owner Dec. 10, 2019 G 2,376,567 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 35 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBRN · iShares Trust 4.94% 6,638 SH Sept. 11, 2026 Daily
GURU · Global X Funds 1.09% 14,083 NS July 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.73% 76,534 NS July 31, 2026 N-PORT
BBC · ETFis Series Trust I 0.72% 7,035 NS July 31, 2026 N-PORT
IBB · iShares Trust 0.40% 737,768 SH Sept. 11, 2026 Daily
IWO · iShares Trust 0.38% 988,363 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.38% 8,611 SH Oct. 2, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.34% 112,682 SH Aug. 19, 2026 Daily
ESSC · Strategy Shares 0.23% 1,785 NS July 31, 2026 N-PORT
PWS · Pacer Funds Trust 0.21% 1,046 NS July 31, 2026 N-PORT
IWM · iShares Trust 0.20% 2,857,880 SH Sept. 11, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.19% 643,358 SH Aug. 19, 2026 Daily
BKSE · BNY Mellon ETF Trust 0.17% 3,180 NS July 31, 2026 N-PORT
RSSL · Global X Funds 0.17% 53,534 NS July 31, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.16% 23,797 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.06% 1,141,089 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.06% 224,721 SH Aug. 19, 2026 Daily
ESML · iShares Trust 0.06% 29,351 SH Sept. 11, 2026 Daily
FBCG · FIDELITY COVINGTON TRUST 0.05% 79,589 NS July 31, 2026 N-PORT
ISCG · iShares Trust 0.05% 9,027 SH Sept. 11, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.05% 35,479 NS July 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.05% 26,694 SH Oct. 2, 2026 Daily
WSML · iShares Trust 0.04% 5,311 SH Sept. 11, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.02% 7,030 SH Aug. 19, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 5,664 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.01% 3,428,276 SH Aug. 19, 2026 Daily
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0.01% 89,618 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 9,206 SH Aug. 19, 2026 Daily
ESGV · VANGUARD WORLD FUND 0.01% 24,696 SH Aug. 19, 2026 Daily
IWV · iShares Trust 0.01% 29,962 SH Sept. 11, 2026 Daily
ITOT · iShares Trust 0.01% 134,626 SH Sept. 11, 2026 Daily
TILT · FlexShares Trust 0.01% 3,402 NS July 31, 2026 N-PORT
IWN · iShares Trust · 62,011 SH Sept. 11, 2026 Daily
ISCB · iShares Trust · 3,926 SH Sept. 11, 2026 Daily
ISCV · iShares Trust · 13,116 SH Sept. 11, 2026 Daily

SRRK Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 24 analysts BUY
Median target $71.50 +52.7%
9 37.5% Strong Buy
14 58.3% Buy
1 4.2% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

16 analysts · 2026-09-29

Mean target $70.44 +50.5%

← Below all targets Current price $46.81
Low$58.00 Mean$70.44 High$84.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SRRK $4.78B -13.4 · · -157.9% ·
IOVA $1.12B -2.5 60.6% -148.4% -56.0% ·
GRAL $3.45B -7.7 17.2% -277.5% -16.7% ·
RYTM $7.19B -34.4 45.8% -103.6% -309.1% ·
CGON $3.35B -20.0 254.7% -3985.0% -22.6% ·
KOD $1.73B -6.5 · · -202.0% ·
ORKA $1.48B -3.3 · · -25.9% ·
MIRM $4.10B -168.1 54.7% -4.5% -8.2% ·
COGT $5.72B -16.4 · · -83.1% ·
TVTX $3.47B -131.8 110.5% -5.2% -34.6% ·
PTCT $6.19B 9.8 114.5% 39.4% -331.5% ·

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26

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Source: SEC 10-Q filed Aug 6, 2026