| RA CAPITAL MANAGEMENT, L.P. |
$86,996,426 |
10,860,977 |
11.65% |
주식
|
| Rubric Capital Management LP |
$68,412,297 |
8,540,861 |
9.16% |
주식
|
| ORBIMED ADVISORS LLC |
$66,390,965 |
8,288,510 |
8.89% |
주식
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$60,105,534 |
7,503,812 |
8.05% |
주식
|
| BlackRock, Inc. |
$42,543,666 |
5,311,319 |
5.70% |
주식
|
| VANGUARD GROUP INC |
$40,881,877 |
3,509,174 |
5.48% |
주식
|
| Tyro Capital Management LLC |
$35,719,289 |
4,459,337 |
4.78% |
주식
|
| Aberdeen Group plc |
$33,406,738 |
4,170,629 |
4.47% |
주식
|
| SR One Capital Management, LP |
$32,143,353 |
4,012,903 |
4.30% |
주식
|
| STATE STREET CORP |
$29,882,290 |
3,730,623 |
4.00% |
주식
|
| Capital World Investors |
$22,066,997 |
2,754,931 |
2.96% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$20,453,759 |
2,553,528 |
2.74% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$19,231,505 |
2,400,937 |
2.58% |
주식
|
| UBS Group AG |
$15,536,629 |
1,939,654 |
2.08% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$13,612,279 |
1,699,017 |
1.82% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$12,828,047 |
1,601,504 |
1.72% |
주식
|
| GENERAL AMERICAN INVESTORS CO INC |
$9,075,698 |
1,133,046 |
1.22% |
주식
|
| Third Point LLC |
$8,010,000 |
1,000,000 |
1.07% |
주식
|
| PEREGRINE CAPITAL MANAGEMENT LLC |
$5,383,833 |
672,139 |
0.72% |
주식
|
| Tejara Capital Ltd |
$4,862,382 |
607,039 |
0.65% |
주식
|
| ADAR1 Capital Management, LLC |
$4,814,002 |
600,999 |
0.64% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4,540,300 |
566,829 |
0.61% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4,416,842 |
551,416 |
0.59% |
주식
|
| NORTHERN TRUST CORP |
$4,398,003 |
549,064 |
0.59% |
주식
|
| LEVIN CAPITAL STRATEGIES, L.P. |
$4,397,210 |
548,965 |
0.59% |
주식
|
| CITADEL ADVISORS LLC |
$4,253,814 |
531,063 |
0.57% |
주식
|
| Empire Life Investments Inc. |
$3,779,567 |
471,856 |
0.51% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$3,731,388 |
464,681 |
0.50% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$3,710,681 |
463,256 |
0.50% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$3,692,618 |
461,001 |
0.49% |
주식
|
| FIL Ltd |
$3,649,156 |
455,575 |
0.49% |
주식
|
| JPMORGAN CHASE & CO |
$3,109,986 |
363,316 |
0.42% |
주식
|
| GOLDMAN SACHS GROUP INC |
$3,049,967 |
380,770 |
0.41% |
주식
|
| Eversept Partners, LP |
$3,019,826 |
377,007 |
0.40% |
주식
|
| K2 PRINCIPAL FUND, L.P. |
$3,004,807 |
375,132 |
0.40% |
주식
|
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV |
$2,991,663 |
373,491 |
0.40% |
주식
|
| FMR LLC |
$2,796,806 |
349,164 |
0.37% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$2,551,850 |
318,583 |
0.34% |
주식
|
| Trexquant Investment LP |
$2,296,731 |
286,733 |
0.31% |
주식
|
| Jump Financial, LLC |
$2,044,152 |
255,200 |
0.27% |
주식
|
| MORGAN STANLEY |
$1,835,091 |
229,100 |
0.25% |
주식
|
| FAS Wealth Partners, Inc. |
$1,718,202 |
214,507 |
0.23% |
주식
|
| Quinn Opportunity Partners LLC |
$1,401,750 |
175,000 |
0.19% |
주식
|
| Bank of New York Mellon Corp |
$1,346,769 |
168,136 |
0.18% |
주식
|
| DAFNA Capital Management LLC |
$1,315,923 |
164,285 |
0.18% |
주식
|
| Nuveen, LLC |
$1,292,350 |
161,342 |
0.17% |
주식
|
| Ishara Investments LP |
$1,149,355 |
143,490 |
0.15% |
주식
|
| Engineers Gate Manager LP |
$1,116,746 |
139,419 |
0.15% |
주식
|
| Steward Partners Investment Advisory, LLC |
$1,030,086 |
128,600 |
0.14% |
주식
|
| BARCLAYS PLC |
$1,011,352 |
126,261 |
0.14% |
주식
|
| AMERICAN ASSETS INC |
$1,001,250 |
125,000 |
0.13% |
주식
|
| Quantinno Capital Management LP |
$996,676 |
124,429 |
0.13% |
주식
|
| MARSHALL WACE, LLP |
$990,949 |
123,714 |
0.13% |
주식
|
| CenterBook Partners LP |
$990,228 |
123,624 |
0.13% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$961,200 |
120,000 |
0.13% |
콜 옵션
|
| DIMENSIONAL FUND ADVISORS LP |
$925,339 |
115,523 |
0.12% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$922,752 |
115,200 |
0.12% |
콜 옵션
|
| SEI INVESTMENTS CO |
$838,190 |
104,643 |
0.11% |
주식
|
| Parkman Healthcare Partners LLC |
$822,627 |
102,700 |
0.11% |
주식
|
| Swiss National Bank |
$757,746 |
94,600 |
0.10% |
주식
|
| Kodai Capital Management LP |
$756,196 |
60,111 |
0.10% |
주식
|
| Corient Private Wealth LP |
$729,248 |
91,042 |
0.10% |
주식
|
| CITIGROUP INC |
$714,484 |
89,199 |
0.10% |
주식
|
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV |
$666,633 |
83,225 |
0.09% |
주식
|
| RHUMBLINE ADVISERS |
$608,660 |
75,989 |
0.08% |
주식
|
| Headlands Technologies LLC |
$602,985 |
75,279 |
0.08% |
주식
|
| AssuredPartners Investment Advisors, LLC |
$586,816 |
73,260 |
0.08% |
주식
|
| XTX Topco Ltd |
$586,228 |
73,187 |
0.08% |
주식
|
| Norman Fields, Gottscho Capital Management, LLC |
$569,351 |
71,080 |
0.08% |
주식
|
| Matisse Capital |
$539,849 |
67,229 |
0.07% |
주식
|
| DEUTSCHE BANK AG\ |
$527,587 |
65,866 |
0.07% |
주식
|
| DIKER MANAGEMENT LLC |
$525,000 |
65,508 |
0.07% |
주식
|
| Balyasny Asset Management L.P. |
$517,911 |
64,658 |
0.07% |
주식
|
| Rafferty Asset Management, LLC |
$509,228 |
63,574 |
0.07% |
주식
|
| WELLS FARGO & COMPANY/MN |
$504,590 |
62,995 |
0.07% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$481,481 |
60,110 |
0.06% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$477,705 |
59,490 |
0.06% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$474,192 |
59,200 |
0.06% |
풋 옵션
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$467,888 |
58,413 |
0.06% |
주식
|
| Coastal Bridge Advisors, LLC |
$447,262 |
55,838 |
0.06% |
주식
|
| ROYCE & ASSOCIATES LP |
$432,732 |
54,024 |
0.06% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$419,724 |
52,400 |
0.06% |
주식
|
| SCHULHOFF & CO INC |
$409,711 |
51,150 |
0.05% |
주식
|
| K2 PRINCIPAL FUND, L.P. |
$384,480 |
48,000 |
0.05% |
콜 옵션
|
| AlphaQuest LLC |
$384,101 |
32,970 |
0.05% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$369,445 |
46,123 |
0.05% |
주식
|
| TUDOR INVESTMENT CORP ET AL |
$367,619 |
45,895 |
0.05% |
주식
|
| Permanent Capital Management, LP |
$347,498 |
43,383 |
0.05% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$323,508 |
40,388 |
0.04% |
주식
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$320,801 |
40,050 |
0.04% |
주식
|
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management |
$317,028 |
39,579 |
0.04% |
주식
|
| Legal & General Group Plc |
$312,490 |
38,988 |
0.04% |
주식
|
| Invesco Ltd. |
$311,516 |
38,891 |
0.04% |
주식
|
| MetLife Investment Management, LLC |
$293,518 |
36,644 |
0.04% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$290,452 |
35,754 |
0.04% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$285,764 |
35,676 |
0.04% |
주식
|
| Everstar Asset Management, LLC |
$270,193 |
33,732 |
0.04% |
주식
|
| VARCOV Co. |
$263,889 |
32,945 |
0.04% |
주식
|
| WINTON GROUP Ltd |
$263,529 |
32,900 |
0.04% |
주식
|
| PROFUND ADVISORS LLC |
$257,914 |
32,199 |
0.03% |
주식
|
| Verition Fund Management LLC |
$246,308 |
30,750 |
0.03% |
주식
|
| Cresset Asset Management, LLC |
$241,518 |
30,152 |
0.03% |
주식
|
| SECTORAL ASSET MANAGEMENT INC |
$239,499 |
29,900 |
0.03% |
주식
|
| PRINCIPAL FINANCIAL GROUP INC |
$238,113 |
29,727 |
0.03% |
주식
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$237,096 |
29,600 |
0.03% |
주식
|
| ALLSTATE CORP |
$236,704 |
29,551 |
0.03% |
주식
|
| WOLVERINE TRADING, LLC |
$235,866 |
24,266 |
0.03% |
주식
|
| WOLVERINE TRADING, LLC |
$218,700 |
22,500 |
0.03% |
콜 옵션
|
| AXQ CAPITAL, LP |
$214,195 |
26,741 |
0.03% |
주식
|
| Vanguard Global Advisers, LLC |
$212,545 |
26,535 |
0.03% |
주식
|
| LPL Financial LLC |
$209,734 |
26,184 |
0.03% |
주식
|
| Private Advisor Group, LLC |
$209,002 |
26,092 |
0.03% |
주식
|
| Belpointe Asset Management LLC |
$206,306 |
25,756 |
0.03% |
주식
|
| HighTower Advisors, LLC |
$205,769 |
25,689 |
0.03% |
주식
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$200,250 |
25,000 |
0.03% |
주식
|
| Squarepoint Ops LLC |
$199,481 |
24,904 |
0.03% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$197,438 |
24,649 |
0.03% |
주식
|
| Creative Planning |
$194,811 |
24,321 |
0.03% |
주식
|
| Magnetar Financial LLC |
$182,660 |
22,804 |
0.02% |
주식
|
| JANUS HENDERSON GROUP PLC |
$173,556 |
21,600 |
0.02% |
주식
|
| CITADEL ADVISORS LLC |
$165,006 |
20,600 |
0.02% |
콜 옵션
|
| Schonfeld Strategic Advisors LLC |
$164,572 |
20,546 |
0.02% |
주식
|
| GUGGENHEIM CAPITAL LLC |
$161,474 |
20,159 |
0.02% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$155,386 |
19,399 |
0.02% |
주식
|
| SHERBROOKE PARK ADVISERS LLC |
$153,069 |
13,139 |
0.02% |
주식
|
| Mariner, LLC |
$150,359 |
18,771 |
0.02% |
주식
|
| JANE STREET GROUP, LLC |
$144,156 |
17,997 |
0.02% |
주식
|
| Quarry LP |
$141,969 |
17,724 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$141,833 |
17,707 |
0.02% |
주식
|
| Russell Investments Group, Ltd. |
$139,285 |
17,389 |
0.02% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$138,717 |
17,318 |
0.02% |
주식
|
| Tannin Capital LLC |
$131,684 |
16,440 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$126,590 |
15,804 |
0.02% |
주식
|
| State of New Jersey Common Pension Fund D |
$122,161 |
15,251 |
0.02% |
주식
|
| CITADEL ADVISORS LLC |
$119,349 |
14,900 |
0.02% |
풋 옵션
|
| INTECH INVESTMENT MANAGEMENT LLC |
$118,812 |
14,833 |
0.02% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$111,267 |
13,891 |
0.01% |
주식
|
| ARIZONA STATE RETIREMENT SYSTEM |
$104,250 |
13,015 |
0.01% |
주식
|
| nVerses Capital, LLC |
$102,888 |
12,845 |
0.01% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$98,659 |
12,317 |
0.01% |
주식
|
| JONES FINANCIAL COMPANIES LLLP |
$94,282 |
11,040 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$92,916 |
11,600 |
0.01% |
주식
|
| AMERICAN CENTURY COMPANIES INC |
$92,099 |
11,498 |
0.01% |
주식
|
| ProShare Advisors LLC |
$90,713 |
11,325 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$84,906 |
10,600 |
0.01% |
주식
|
| Abel Hall, LLC |
$84,393 |
10,536 |
0.01% |
주식
|
| Pictet Asset Management Holding SA |
$83,000 |
10,362 |
0.01% |
주식
|
| Allianz Asset Management GmbH |
$81,702 |
10,200 |
0.01% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$80,460 |
10,045 |
0.01% |
주식
|
| SYON CAPITAL LLC |
$80,420 |
10,040 |
0.01% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$66,643 |
8,320 |
0.01% |
주식
|
| Rockefeller Capital Management L.P. |
$43,687 |
5,454 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$39,153 |
4,888 |
0.01% |
주식
|
| DIADEMA PARTNERS LP |
$38,929 |
4,860 |
0.01% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$35,572 |
4,441 |
0.00% |
주식
|
| SIMPLEX TRADING, LLC |
$33,786 |
4,218 |
0.00% |
주식
|
| Arax Advisory Partners |
$33,394 |
4,169 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$31,000 |
3,874 |
0.00% |
주식
|
| Tower Research Capital LLC (TRC) |
$27,562 |
3,441 |
0.00% |
주식
|
| SIGNATUREFD, LLC |
$25,728 |
3,212 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$24,005 |
2,997 |
0.00% |
주식
|
| OSTERWEIS CAPITAL MANAGEMENT INC |
$21,122 |
2,637 |
0.00% |
주식
|
| Bernard Wealth Management Corp. |
$19,385 |
2,420 |
0.00% |
주식
|
| TD Waterhouse Canada Inc. |
$17,131 |
2,160 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$16,941 |
2,115 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$16,773 |
2,094 |
0.00% |
주식
|
| Smartleaf Asset Management LLC |
$16,709 |
1,952 |
0.00% |
주식
|
| Janney Montgomery Scott LLC |
$16,537 |
2,064,498 |
0.00% |
주식
|
| CAZ INVESTMENTS LP |
$16,020 |
2,000 |
0.00% |
주식
|
| US BANCORP \DE\ |
$12,808 |
1,599 |
0.00% |
주식
|
| GAMMA Investing LLC |
$10,061 |
1,256 |
0.00% |
주식
|
| Persistent Asset Partners Ltd |
$9,940 |
1,241 |
0.00% |
주식
|
| Lindbrook Capital, LLC |
$9,536 |
758 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$9,085 |
2,108 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$8,138 |
1,016 |
0.00% |
주식
|
| Heritage Wealth Advisors |
$8,010 |
1,000 |
0.00% |
주식
|
| Global Retirement Partners, LLC |
$7,930 |
990 |
0.00% |
주식
|
| Ameritas Advisory Services, LLC |
$7,097 |
886 |
0.00% |
주식
|
| CWM, LLC |
$6,697 |
834 |
0.00% |
주식
|
| Allworth Financial LP |
$6,609 |
825 |
0.00% |
주식
|
| Caitong International Asset Management Co., Ltd |
$4,470 |
558 |
0.00% |
주식
|
| BROWN, LISLE/CUMMINGS, INC. |
$3,204 |
400 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$2,997 |
374 |
0.00% |
주식
|
| HARBOUR INVESTMENTS, INC. |
$2,964 |
370 |
0.00% |
주식
|
| Hilton Head Capital Partners, LLC |
$2,924 |
365 |
0.00% |
주식
|
| COMERICA BANK |
$2,528 |
217 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$1,730 |
216 |
0.00% |
주식
|
| HighMark Wealth Management LLC |
$1,602 |
200 |
0.00% |
주식
|
| Tidemark, LLC |
$1,354 |
169 |
0.00% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1,177 |
147 |
0.00% |
주식
|
| Optiver Holding B.V. |
$1,121 |
140 |
0.00% |
주식
|
| GROUP ONE TRADING LLC |
$1,001 |
125 |
0.00% |
주식
|
| Larson Financial Group LLC |
$873 |
109 |
0.00% |
주식
|
| SIT INVESTMENT ASSOCIATES INC |
$744 |
92,875 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$737 |
92 |
0.00% |
주식
|
| Cambridge Investment Research Advisors, Inc. |
$698 |
87,161 |
0.00% |
주식
|
| Parkside Financial Bank & Trust |
$641 |
80 |
0.00% |
주식
|
| JPL Wealth Management, LLC |
$441 |
55 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$406 |
50,579 |
0.00% |
주식
|
| Essential Partners LLC |
$264 |
33 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$256 |
32 |
0.00% |
주식
|
| Strategic Wealth Partners, Ltd. |
$160 |
20 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$140 |
17,534 |
0.00% |
주식
|
| FOSTER & MOTLEY INC |
$118 |
14,780 |
0.00% |
주식
|
| AMICA MUTUAL INSURANCE CO |
$115 |
14,350 |
0.00% |
주식
|
| Virtu Financial LLC |
$88 |
10,938 |
0.00% |
주식
|
| IFP Advisors, Inc |
$88 |
11 |
0.00% |
주식
|
| Silver Grove Financial Group, Inc. |
$72 |
9 |
0.00% |
주식
|
| BESSEMER GROUP INC |
$60 |
7,525 |
0.00% |
주식
|
| Clearstead Advisors, LLC |
$42 |
5 |
0.00% |
주식
|
| Keating Financial Advisory Services, Inc. |
$40 |
5 |
0.00% |
주식
|
| GHP Investment Advisors, Inc. |
$25 |
3 |
0.00% |
주식
|
| Wealth Enhancement Trust Services, Inc. |
$16 |
2 |
0.00% |
주식
|
| CX Institutional |
$12 |
2,890 |
0.00% |
주식
|
| Capital Analysts, LLC |
$10 |
1,300 |
0.00% |
주식
|
| SJS Investment Consulting Inc. |
$9 |
1 |
0.00% |
주식
|
| Pacer Advisors, Inc. |
$9 |
1,062 |
0.00% |
주식
|
| Hughes Financial Services, LLC |
$8 |
1 |
0.00% |
주식
|
| LANARK FINANCIAL, INC. |
$8 |
1 |
0.00% |
주식
|
| Avion Wealth |
$4 |
500 |
0.00% |
주식
|
| Amica Retiree Medical Trust |
$3 |
346 |
0.00% |
주식
|
| Covestor Ltd |
$0 |
46 |
0.00% |
주식
|