NGNE Neurogene Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$37.30
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026
52W Range
$16–$44
77% of range
Analyst Rating
BUY
15 analysts
Price Target
$80
+116% upside
P/E (TTM)
-8.9
ROE
-33.6%
Net Profit Margin
—

NGNE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$37.30
Market Cap
$582M
P/E (TTM)
-8.9
EPS (TTM)
$-4.24
Revenue (TTM)
$0
Div Yield
—
ROE
-33.6%
Debt/Equity
—
52W Range
$16 – $44

NGNE Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
4-point trend, -100.0%
2018-12-31 → 2025-12-31
EPS $-4.24
5-point trend, -562.5%
2020-12-31 → 2025-12-31
Free Cash Flow $-78M
9-point trend, -153.3%
2016-12-31 → 2025-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
NGNE
Peer Median
P/E (TTM)
5-point trend, +94.5%
-8.9
13.2
P/B
5-point trend, -95.8%
2.2
2.1
Price / FCF
5-point trend, +94.9%
-7.4
—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
NGNE
Peer Median
ROA
5-point trend, +10.9%
-28.9%
-29.6%
ROE
5-point trend, +17.6%
-33.6%
-32.0%
ROIC
-39.0%
—

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
NGNE
Peer Median
Current Ratio
5-point trend, -0.7%
16.6
6.0
Quick Ratio
5-point trend, -0.6%
16.4
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
NGNE
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
NGNE
Peer Median
EPS (Diluted)
5-point trend, -562.5%
$-4.24
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
NGNE
Peer Median

NGNE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 15 analysts
  • Strong Buy 6 40.0%
  • Buy 8 53.3%
  • Hold 1 6.7%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

7 analysts · 2026-08-15
Median target $65.00 +74.3%
Mean target $80.43 +115.6%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.09%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-1.39 $-1.32 -0.07%
Dec. 31, 2025 $-1.17 $-1.21 0.04%
Sept. 30, 2025 $-0.99 $-1.27 0.28%
June 30, 2025 $-1.05 $-1.18 0.13%
March 31, 2025 $-1.08 $-1.08 0.00%
Dec. 31, 2024 $-0.99 $-1.15 0.16%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
NGNE $319M -4.9 — — -33.6% —
AURA $347M -3.1 -29.7% -1601.4% -68.2% —
MNPR — — — — — —
ACHV — -4.0 — — — —
CTMX $725M — -44.8% -22.8% -15.9% —
RGNX $733M -3.8 104.5% -113.8% -122.5% —
STTK $231M -5.2 -82.5% -4880.9% -70.0% —
BBOT $1.00B -2.9 — — -146.2% —
IRWD $550M 22.5 -15.7% 8.1% -8.5% —
FDMT $432M -3.1 230194.6% -164.4% -30.2% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for NGNE
Metric Trend 20252024202320222021202020192018
Revenue 4-point trend, -100.0% $0 $925.0K $0 · · · · $25M
R&D Expense 6-point trend, +79.5% $75M $61M $44M $48M $39M · · $42M
SG&A Expense 8-point trend, +78.8% $28M $23M $11M $9M $22M $17M $19M $16M
Operating Expenses 7-point trend, +79.3% $103M $84M $56M $57M $61M · $71M $58M
Operating Income 8-point trend, -216.7% $-103M $-83M $-56M $-57M $-61M $-34M $-71M $-33M
Interest Expense 4-point trend, +200.0% · · $12.0K $2.0K · · $1.0K $4.0K
Interest Income 4-point trend, +763.6% $12M $8M $3M $1M · · · ·
Other Non-op 7-point trend, +1144.2% $13M $7M · $-42.0K $-13.0K $-44.0K $-9.0K $1M
Pretax Income 8-point trend, -186.1% $-90M $-75M $-36M $-55M $-61M $-33M $-69M $-32M
Income Tax Flat — no change across 2 periods $0 $0 · · · · · ·
Net Income 8-point trend, -186.1% $-90M $-75M $-36M $-55M $-61M $-33M $-69M $-32M
EPS (Basic) 5-point trend, -562.5% $-4.24 $-4.28 · $-1.04 $-1.10 $-0.64 · ·
EPS (Diluted) 5-point trend, -562.5% $-4.24 $-4.28 · $-1.04 $-1.10 $-0.64 · ·
Shares (Basic) 5-point trend, -58.8% 21,326,283 17,567,082 · 55,221,161 55,041,662 51,825,022 · ·
Shares (Diluted) 5-point trend, -58.8% 21,326,283 17,567,082 · 55,221,161 55,041,662 51,825,022 · ·
EBITDA 7-point trend, -42.0% $-100M $-79M $-52M $-58M $-59M $-33M $-71M ·
Balance Sheet 24
Annual Balance Sheet data for NGNE
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, +35.0% $104M $137M $148M $82M $142M $193M $143M $77M
Short-term Investments 5-point trend, +165168000.00 $165M $176M $49M $0 $0 · · ·
Prepaid Expense 4-point trend, +2.2% $3M $4M $3M $3M · · · ·
Other Current Assets 7-point trend, -66.6% $168.0K $981.0K $1M $630.0K $2M $2M $503.0K ·
Current Assets 8-point trend, +252.2% $272M $316M $200M $85M $144M $195M $144M $77M
PP&E (Net) 8-point trend, +3098.0% $13M $15M $17M $20M $6M $4M $2M $400.0K
PP&E (Gross) 7-point trend, +3091.1% $27M $27M $25M $25M · $4M $3M $843.0K
Accum. Depreciation 7-point trend, +3084.9% $14M $11M $8M $5M · $585.0K $688.0K $443.0K
Intangibles 4-point trend, -100.0% · · · $0 $128.0K $347.0K $567.0K ·
Other Non-current Assets 7-point trend, +3343.3% $1M $975.0K $764.0K $0 $2M $2M $30.0K ·
Total Assets 8-point trend, +271.8% $289M $336M $223M $109M $163M $211M $147M $78M
Accounts Payable 7-point trend, -52.7% $2M $1M $3M $625.0K $7M $7M $4M ·
Accrued Liabilities 4-point trend, +102.0% $11M $10M $17M $5M · · · ·
Current Liabilities 8-point trend, +254.7% $16M $15M $23M $7M $9M $8M $5M $5M
Capital Leases 8-point trend, +113600.0% $7M $9M $12M $4M $12M $11M $447.0K $6.0K
Other Non-current Liabilities 5-point trend, -84.0% $51.0K $51.0K $203.0K $0 · · · $319.0K
Total Liabilities 8-point trend, +379.5% $24M $25M $37M $11M $20M $19M $5M $5M
Common Stock Flat — no change across 7 periods $0 $0 $0 $0 $0 $0 $0 ·
Paid-in Capital 8-point trend, +104.0% $618M $573M $373M $5M $536M $524M $441M $303M
Retained Earnings 8-point trend, -53.3% $-353M $-262M $-187M $-151M $-393M $-333M $-300M $-230M
AOCI 2-point trend, -21000.00 · · · $-21.0K $0 · · ·
Stockholders' Equity 8-point trend, +264.5% $265M $310M $186M $-146M $-92M $191M $142M $73M
Liabilities + Equity 8-point trend, +271.8% $289M $336M $223M $109M $163M $211M $147M $78M
Shares Outstanding 8-point trend, -34.2% 15,489,800 14,854,725 12,823,665 0 0 42,196,296 37,996,849 23,537,368
Cash Flow 13
Annual Cash Flow data for NGNE
Metric Trend 20252024202320222021202020192018
D&A 8-point trend, +952.9% $3M $3M $3M $3M $1M $785.0K $340.0K $289.0K
Stock-based Comp 8-point trend, +201.9% $14M $8M $1M $1M $12M $6M $8M $5M
Amort. of Intangibles 3-point trend, -50.0% · · · $100.0K $200.0K $200.0K · ·
Restructuring 2-point trend, +1400000.00 · · · $1M · $0 · ·
Other Non-cash 7-point trend, -108.8% $-4M $-7M $-20M $2M $271.0K $2M $46M ·
Operating Cash Flow 8-point trend, -144.4% $-77M $-71M $-51M $-53M $-48M $-25M $-15M $-32M
CapEx 8-point trend, +2314.3% $1M $808.0K $321.0K $2M $3M $2M $879.0K $49.0K
Investing Cash Flow 8-point trend, -75.0% $14M $-125M $26M $-2M $-3M $-2M $-688.0K $56M
Stock Issued 7-point trend, -62.5% $30M $0 $92M $0 $0 $72M $81M ·
Net Stock Activity 6-point trend, -64.8% $30M $0 $92M · $0 $72M $86M ·
Financing Cash Flow 8-point trend, +5238.2% $30M $184M $92M $67M $732.0K $77M $82M $570.0K
Net Change in Cash 8-point trend, -231.5% $-33M $-12M $67M $11M $-50M $50M $66M $25M
Free Cash Flow 7-point trend, -381.5% $-78M $-71M $-52M $-47M $-51M $-27M $-16M ·
Profitability 7
Annual Profitability data for NGNE
Metric Trend 20252024202320222021202020192018
Operating Margin 2-point trend, -139.1% · -8930.3% · -3735.6% · · · ·
Net Margin 2-point trend, -123.3% · -8123.7% · -3638.2% · · · ·
Pretax Margin 2-point trend, -123.2% · -8123.7% · -3639.6% · · · ·
EBITDA Margin 2-point trend, -136.0% · -8584.9% · -3636.9% · · · ·
ROA 7-point trend, +53.2% -28.9% -26.9% -21.9% -41.2% -32.5% -18.6% -61.8% ·
ROE 7-point trend, +49.6% -33.6% -33.6% -2580.2% -57.6% -40.8% -17.0% -66.6% ·
ROIC -39.0% · · · · · · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for NGNE
Metric Trend 20252024202320222021202020192018
Current Ratio 7-point trend, -45.3% 16.6 20.8 8.7 9.0 16.7 24.7 30.3 ·
Quick Ratio 7-point trend, -45.7% 16.4 20.6 8.6 8.7 16.5 24.4 30.2 ·
Interest Coverage 2-point trend, +93.5% · · -4631.9 · · · -70959.0 ·
Efficiency 1
Annual Efficiency data for NGNE
Metric Trend 20252024202320222021202020192018
Asset Turnover 3-point trend, -100.0% 0.0 0.0 · 0.0 · · · ·
Per Share 5
Annual Per Share data for NGNE
Metric Trend 20252024202320222021202020192018
Book Value / Share 7-point trend, +358.6% $17.10 $20.89 $14.51 $2.21 $3.36 $4.53 $3.73 ·
Revenue / Share 3-point trend, -100.0% $0.00 $0.05 · $0.03 · · · ·
Cash Flow / Share 4-point trend, -318.8% $-3.62 $-4.02 · $-0.83 $-0.86 · · ·
Cash / Share 7-point trend, +78.0% $6.70 $9.19 $11.56 $0.89 $3.36 $4.56 $3.77 ·
EPS (TTM) 6-point trend, -562.5% $-4.24 $-4.28 $-60.79 $-1.04 $-1.10 $-0.64 · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for NGNE
Metric Trend 20252024202320222021202020192018
Revenue TTM 4-point trend, -100.0% $0 $925.0K $0 · · · · $25M
Net Income TTM 8-point trend, -186.1% $-90M $-75M $-36M $-55M $-61M $-33M $-69M $-32M
Market Cap 7-point trend, -96.6% $319M $340M $249M $434M $4.09B $11.90B $9.36B ·
P/E 6-point trend, +98.9% -4.9 -5.3 -0.3 -9.8 -87.6 -440.6 · ·
P/S · 367.1 · · · · · ·
P/B 7-point trend, -98.2% 1.2 1.1 1.3 4.6 28.6 62.2 66.1 ·
P / Tangible Book 4-point trend, -98.1% 1.2 1.1 1.3 · · 62.3 · ·
P / Cash Flow 7-point trend, +99.3% -4.1 -4.8 -4.8 -9.5 -86.1 -484.2 -608.2 ·
P / FCF 7-point trend, +99.3% -4.1 -4.8 -4.8 -9.3 -80.5 -444.1 -575.3 ·
Earnings Yield 6-point trend, -8847.8% -20.6% -18.7% -313.7% -10.2% -1.1% -0.23% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0$925.0K$0——
Operating Margin % —-8930.3%—-3735.6%—
Net Income $-90M$-75M$-36M$-55M$-61M
Diluted EPS $-4.24$-4.28—$-1.04$-1.10
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 16.620.88.79.016.7
Quick Ratio 16.420.68.68.716.5
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-78M$-71M$-52M$-47M$-51M

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Institutional owners (13F) 123 filers · $477.5M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
27 (+7 vs prior Q) 4 (-7 vs prior Q) 32 (-9 vs prior Q) 34 (+15 vs prior Q) +572K

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
SAMSARA BIOCAPITAL, LLC $54,003,644 1,717,127 11.31% Shares
Casdin Capital, LLC $48,601,603 1,545,361 10.18% Shares
Redmile Group, LLC $44,413,659 1,412,199 9.30% Shares
RTW INVESTMENTS, LP $42,849,241 1,362,456 8.97% Shares
EcoR1 Capital, LLC $39,983,706 1,271,342 8.37% Shares
BAKER BROS. ADVISORS LP $31,188,682 991,691 6.53% Shares
Balyasny Asset Management L.P. $25,748,307 818,706 5.39% Shares
Trails Edge Capital Partners, LP $22,483,133 714,885 4.71% Shares
TORONTO DOMINION BANK $21,428,049 681,337 4.49% Shares
VANGUARD CAPITAL MANAGEMENT LLC $16,873,711 536,525 3.53% Shares
JENNISON ASSOCIATES LLC $16,309,405 518,582 3.42% Shares
GREAT POINT PARTNERS LLC $11,076,061 352,180 2.32% Shares
ArrowMark Colorado Holdings LLC $10,770,147 342,453 2.26% Shares
FMR LLC $9,295,393 295,561 1.95% Shares
GEODE CAPITAL MANAGEMENT, LLC $7,926,306 251,964 1.66% Shares
STATE STREET CORP $7,054,927 224,322 1.48% Shares
CITADEL ADVISORS LLC $4,747,315 150,948 0.99% Shares
BLAIR WILLIAM & CO/IL $4,620,162 146,905 0.97% Shares
Driehaus Capital Management LLC $4,513,956 143,528 0.95% Shares
Point72 Asset Management, L.P. $4,463,384 141,920 0.93% Shares
MOORE CAPITAL MANAGEMENT, LP $4,454,452 141,636 0.93% Shares
Rock Springs Capital Management LP $3,357,288 106,750 0.70% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $3,006,651 95,601 0.63% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,905,980 92,400 0.61% Call option
DAFNA Capital Management LLC $2,800,056 89,032 0.59% Shares
Woodline Partners LP $2,636,611 83,835 0.55% Shares
VANGUARD FIDUCIARY TRUST CO $2,335,540 74,262 0.49% Shares
Trexquant Investment LP $2,319,815 73,762 0.49% Shares
GOLDMAN SACHS GROUP INC $1,979,715 62,948 0.41% Shares
XTX Topco Ltd $1,743,085 55,424 0.37% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $1,688,244 52,300 0.35% Shares
JPMORGAN CHASE & CO $1,680,206 52,051 0.35% Shares
MILLENNIUM MANAGEMENT LLC $1,343,984 42,734 0.28% Shares
Raiffeisen Bank International AG $1,097,520 34,000 0.23% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,029,736 32,742 0.22% Shares
DIMENSIONAL FUND ADVISORS LP $993,694 31,596 0.21% Shares
CITADEL ADVISORS LLC $839,715 26,700 0.18% Call option
Quadrature Capital Ltd $764,864 24,320 0.16% Shares
AMERICAN CENTURY COMPANIES INC $733,729 23,330 0.15% Shares
JANE STREET GROUP, LLC $703,757 22,377 0.15% Shares
Seven Fleet Capital Management LP $693,787 22,060 0.15% Shares
RENAISSANCE TECHNOLOGIES LLC $641,737 20,405 0.13% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $590,662 18,781 0.12% Shares
ALPS ADVISORS INC $504,458 16,040 0.11% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $462,315 14,700 0.10% Put option
RHUMBLINE ADVISERS $445,104 14,153 0.09% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $434,104 13,803 0.09% Shares
DEUTSCHE BANK AG\ $407,215 12,948 0.09% Shares
Mariner, LLC $385,552 12,260 0.08% Shares
Virtus Investment Advisers, LLC $353,624 11,244 0.07% Shares
BANK OF AMERICA CORP /DE/ $349,850 11,124 0.07% Shares
Bank of New York Mellon Corp $339,314 10,789 0.07% Shares
WELLINGTON MANAGEMENT GROUP LLP $312,173 9,926 0.07% Shares
D. E. Shaw & Co., Inc. $307,612 9,781 0.06% Shares
WELLS FARGO & COMPANY/MN $297,863 9,471 0.06% Shares
Pale Fire Capital SE $297,517 9,460 0.06% Shares
ALLIANCEBERNSTEIN L.P. $277,603 13,770 0.06% Shares
Brevan Howard Capital Management LP $263,771 8,387 0.06% Shares
ADAR1 Capital Management, LLC $245,310 7,800 0.05% Shares
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $235,592 7,491 0.05% Shares
CITIGROUP INC $226,912 7,215 0.05% Shares
Mitsubishi UFJ Asset Management Co., Ltd. $191,531 6,090 0.04% Shares
MetLife Investment Management, LLC $186,561 5,932 0.04% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $163,760 5,207 0.03% Shares
Vanguard Global Advisers, LLC $152,658 4,854 0.03% Shares
AlphaQuest LLC $148,629 7,215 0.03% Shares
BlackRock, Inc. $148,004 4,706 0.03% Shares
Invesco Ltd. $141,085 4,486 0.03% Shares
PNC Financial Services Group, Inc. $136,021 4,325 0.03% Shares
NEW YORK STATE COMMON RETIREMENT FUND $132,090 4,200 0.03% Shares
Nuveen, LLC $124,762 3,967 0.03% Shares
Police & Firemen's Retirement System of New Jersey $120,957 3,846 0.03% Shares
NATIXIS $117,025 3,721 0.02% Shares
Nuveen Asset Management, LLC $110,071 4,815 0.02% Shares
VANGUARD GROUP INC $99,992 4,854 0.02% Shares
BARCLAYS PLC $96,676 3,074 0.02% Shares
China Universal Asset Management Co., Ltd. $79,097 2,515 0.02% Shares
BNP PARIBAS FINANCIAL MARKETS $59,692 1,898 0.01% Shares
NORTHERN TRUST CORP $55,855 1,776 0.01% Shares
MERCER GLOBAL ADVISORS INC /ADV $45,036 1,432 0.01% Shares
Cubist Systematic Strategies, LLC $39,200 2,262 0.01% Shares
Legal & General Group Plc $34,532 1,098 0.01% Shares
Ameritas Investment Partners, Inc. $31,733 1,009 0.01% Shares
State of Wyoming $30,821 980 0.01% Shares
Arax Advisory Partners $28,494 906 0.01% Shares
Mirae Asset Global Investments Co., Ltd. $22,235 707 0.00% Shares
CWM, LLC $20,765 1,030 0.00% Shares
GAMMA Investing LLC $17,140 545 0.00% Shares
Russell Investments Group, Ltd. $16,291 518 0.00% Shares
NISA INVESTMENT ADVISORS, LLC $14,561 463 0.00% Shares
Point72 (DIFC) Ltd $14,465 835 0.00% Shares
Tower Research Capital LLC (TRC) $13,838 440 0.00% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $12,177 604 0.00% Shares
ROYAL BANK OF CANADA $11,000 344 0.00% Shares
GF FUND MANAGEMENT CO. LTD. $10,441 332 0.00% Shares
Rockefeller Capital Management L.P. $7,265 231 0.00% Shares
Sterling Capital Management LLC $7,171 228 0.00% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $5,887 292 0.00% Shares
Farther Finance Advisors, LLC $5,646 176 0.00% Shares
US BANCORP \DE\ $4,623 147 0.00% Shares

Company insiders 36 insiders · 17 officers · 18 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Rachel Mcminn Chief Executive Officer March 26, 2025 A 1,274,259 0 0 $0
Jonathan G Drachman President and CEO Aug. 2, 2022 A 25,000 0 0 $0
David Main President and CEO Aug. 7, 2018 A 71,530 0 0 $0
Christine Mikail Cvijic President and CFO July 7, 2026 S 84,040 0 5 $-339,952
Sean Michael Smith Interim CFO, Prin Acct Off Aug. 10, 2023 M 21,637 0 0 $0
Robert Ho Chief Financial Officer Feb. 1, 2022 A 21,503 0 0 $0
Kamran Alam CFO, Vice President Finance Aug. 7, 2018 A 0 0 0 $0
Lloyd Mackenzie Chief Operating Officer Aug. 7, 2018 A 0 0 0 $0
Stuart Cobb Chief Scientific Officer May 14, 2025 S 20,794 0 0 $0
Julie Jordan Chief Medical Officer March 26, 2025 A 8,400 0 0 $0
Donna Cochener General Counsel, SVP Legal Aug. 2, 2022 A — 0 0 $0
Carl Walkey Senior Vice President Aug. 2, 2022 A 1,352,489 0 0 $0
Holly Vance General Counsel Aug. 3, 2021 A — 0 0 $0
Shelley Mccloskey VP, HR and Administration Aug. 7, 2018 A — 0 0 $0
Abigail Jenkins Chief Commercial Officer March 9, 2018 A — 0 0 $0
David Chilton Mitchell VP Global Regulatory & Quality March 8, 2017 A 3,575 0 0 $0
Stephen B Shrewsbury CMO; Senior VP Clinical Dev. March 10, 2016 A — 0 0 $0
Robert Keith Woods Director June 12, 2025 A — 0 0 $0
Cory S. Freedland Director June 12, 2025 A — 0 0 $0
Sarah B. Noonberg Director June 12, 2025 A — 0 0 $0
Rohan Palekar Director June 12, 2025 A — 0 0 $0
Keith Woods Director Jan. 16, 2024 A — 0 0 $0
Erin Lavelle Director June 8, 2023 A — 0 0 $0
Martin Babler Director June 8, 2023 A — 0 0 $0
Todd E Simpson Director June 8, 2023 A — 0 0 $0
Erin M. Lavelle Director May 11, 2021 A — 0 0 $0
Lewis T Williams Director May 11, 2021 A — 0 0 $0
Sean P. Nolan Director May 5, 2020 A — 0 0 $0
Daniel J Levitt Director May 14, 2018 M 0 0 0 $0
Gary Bridger Director May 7, 2018 A 0 0 0 $0
Robert Pelzer Director May 7, 2018 A — 0 0 $0
Pfizer Inc. 10% owner Aug. 10, 2015 S 975,403 0 0 $0
Ventures West 8 Limited Partnership 10% owner March 12, 2014 C 1,543,989 0 0 $0
Robert Baffi — Feb. 20, 2026 A — 0 0 $0
Patel Priti — March 31, 2023 M 37,313 0 0 $0
Barbara Troupin — March 9, 2018 A — 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 4 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Rachel McMinn, Ph.D. Dec. 21, 2023 — Initial filing Passive investment SEC
Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker ×18 filings Dec. 20, 2023 — Initial filing M&A / sale SEC
Redmile Group, LLC, Jeremy C. Green July 27, 2023 — Initial filing M&A / sale SEC
Jonathan G. Drachman Dec. 27, 2019 — Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 25 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBC · ETFis Series Trust I 0.92% 13,193 NS April 30, 2026 N-PORT
IBRN · iShares Trust 0.46% 986 SH Aug. 8, 2026 Daily
SBIO · ALPS ETF Trust 0.28% 15,968 NS May 31, 2026 N-PORT
IWC · iShares Trust 0.09% 38,357 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.04% 116,349 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.04% 855 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.03% 104,127 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.02% 571 NS May 31, 2026 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.02% 20,446 NS May 31, 2026 N-PORT
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 9,854 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.01% 290,274 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 65,030 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.01% 4,875 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.01% 531 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.00% 416 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.00% 420 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 8,413 NS April 30, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 372 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 11 NS May 31, 2026 N-PORT
IWV · iShares Trust 0.00% 4,461 SH Aug. 8, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 2,066 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 126,680 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 397,791 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 722 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.00% 19,995 SH Aug. 8, 2026 Daily