ARDX Ardelyx, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$4.05
Price · Aug 18, 2026
Fundamentals as of Aug 6, 2026

About Ardelyx, Inc. - Common Stock Company overview from Wikipedia

ARDX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$4.04
Market Cap
$988M
P/E (TTM)
-15.6
EPS (TTM)
$-0.26
Revenue (TTM)
$407M
Div Yield
ROE
-40.2%
Debt/Equity
52W Range
$4 – $8

ARDX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $407M
9-point trend, +869.8%
2017-12-31 2025-12-31
EPS $-0.26
7-point trend, +82.3%
2019-12-31 2025-12-31
Free Cash Flow $-44M
10-point trend, +54.9%
2016-12-31 2025-12-31
Margins -15.1%
3-point trend, +10.8%
2017-12-31 2019-12-31

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ARDX
Peer Median
P/E (TTM)
5-point trend, -2998.4%
-15.6
P/S (TTM)
5-point trend, -75.3%
2.4
12.8
P/B
5-point trend, +392.3%
5.9
3.4
Price / FCF
5-point trend, -3393.1%
-22.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ARDX
Peer Median
Operating Margin
5-point trend, +99.3%
-10.1%
Net Profit Margin
5-point trend, +99.0%
-15.1%
-294.4%
ROA
5-point trend, +85.4%
-13.1%
-31.3%
ROE
5-point trend, +79.2%
-40.2%
-38.1%
ROIC
5-point trend, +86.7%
-24.9%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ARDX
Peer Median
Current Ratio
5-point trend, +70.5%
4.3
10.9
Quick Ratio
5-point trend, +14.3%
1.6

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ARDX
Peer Median
Revenue YoY
5-point trend, +3934.1%
22.1%
Revenue CAGR 3Y
5-point trend, +3934.1%
98.4%
Revenue CAGR 5Y
5-point trend, +3934.1%
121.9%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ARDX
Peer Median
EPS (Diluted)
5-point trend, +82.9%
$-0.26

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ARDX
Peer Median

ARDX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

STRONG BUY 18 analysts
  • Strong Buy 10 55.6%
  • Buy 7 38.9%
  • Hold 1 5.6%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

10 analysts · 2026-08-14
Median target $13.50 +233.7%
Mean target $13.00 +221.4%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.01%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.07 $-0.07 -0.00%
March 31, 2026 $-0.15 $-0.15 -0.00%
Dec. 31, 2025 $0.00 $0.01 -0.01%
Sept. 30, 2025 $0.00 $-0.06 0.06%
June 30, 2025 $-0.08 $-0.14 0.06%
March 31, 2025 $-0.17 $-0.12 -0.05%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ARDX $1.42B -22.4 22.1% -15.1% -40.2%
SANA $1.09B -4.2 -172.3%
SVRA $1.23B -11.4 -73.4%
AVTX $336M -3.1 -86.6% -132642.4% -83.4%
ODTX
KURA $913M -3.3 25.2% -413.0% -116.2%
JANX $833M -7.5 -5.5% -1136.2% -11.7%
CLYM $191M -4.5 -34.6%
GERN $845M -10.2 -60.2% -34.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 11-point trend, +1188.0% $407M $334M $124M $52M $10M $8M $5M $3M $42M · $24M $32M
Cost of Revenue 9-point trend, +370.7% $40M $51M $18M $4M $1M $145.0K $600.0K $466.0K $8M · · ·
Gross Profit 4-point trend, -80.5% · · · · · · $5M $2M $34M · $24M ·
R&D Expense 12-point trend, +176.2% $72M $52M $36M $35M $91M $65M $72M $69M $75M $94M $40M $26M
SG&A Expense 12-point trend, +4527.9% $337M $259M $134M $77M $72M $33M $24M $24M $23M $19M $14M $7M
Operating Expenses 12-point trend, +1250.8% $448M $362M $188M $112M $163M $98M $97M $94M $99M $113M $53M $33M
Operating Income 12-point trend, -2520.0% $-41M $-28M $-63M $-64M $-154M $-91M $-91M $-91M $-65M $-113M $-29M $-2M
Interest Expense 6-point trend, +40.1% · · $5M $3M $5M $5M $6M $4M · · · ·
Other Non-op 12-point trend, +87350.0% $9M $9M $7M $2M $687.0K $2M $2M $3M $2M $508.0K $-261.0K $10.0K
Pretax Income 12-point trend, -1826.6% $-61M $-39M $-66M $-67M $-158M $-94M $-95M $-91M $-63M $-112M $-30M $-3M
Income Tax 11-point trend, +1346.3% $969.0K $266.0K $547.0K $8.0K $4.0K $2.0K $303.0K $4.0K $1M · $-29.0K $67.0K
Net Income 12-point trend, -1816.6% $-62M $-39M $-66M $-67M $-158M $-94M $-95M $-91M $-64M $-112M $-30M $-3M
EPS (Basic) 7-point trend, +82.3% $-0.26 $-0.17 $-0.30 $-0.42 $-1.52 $-1.05 $-1.47 · · · · ·
EPS (Diluted) 7-point trend, +82.3% $-0.26 $-0.17 $-0.30 $-0.42 $-1.52 $-1.05 $-1.47 · · · · ·
Shares (Basic) 7-point trend, +273.8% 241,033,750 235,232,927 219,331,253 158,690,083 104,205,645 89,582,138 64,478,066 · · · · ·
Shares (Diluted) 7-point trend, +273.8% 241,033,750 235,232,927 219,331,253 158,690,083 104,205,645 89,582,138 64,478,066 · · · · ·
EBITDA 11-point trend, -29.0% $-38M $-26M $-62M $-63M $-154M $-91M $-91M $-91M $-65M $-113M $-29M ·
Balance Sheet 23
Annual Balance Sheet data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, -36.6% $68M $65M $21M $96M $72M $91M $181M $79M $75M $75M $107M $107M
Receivables 7-point trend, +2680.5% $72M $58M $22M $8M $502.0K $0 · · · · · $3M
Inventory 5-point trend, +123107000.00 $123M $91M $49M $28M $0 · · · · · · ·
Prepaid Expense 12-point trend, +1022.1% $14M $11M $8M $5M $7M $8M $4M $3M $5M $3M $5M $1M
Current Assets 12-point trend, +244.2% $382M $356M $246M $154M $134M $195M $252M $176M $150M $204M $112M $111M
PP&E (Net) 12-point trend, +2.5% $2M $1M $1M $1M $2M $2M $3M $6M $8M $9M $5M $2M
PP&E (Gross) 12-point trend, -16.1% $5M $12M $11M $11M $18M $16M $16M $16M $16M $14M $9M $6M
Accum. Depreciation 12-point trend, -27.1% $3M $11M $10M $10M $16M $14M $13M $10M $8M $5M $4M $4M
Other Non-current Assets 12-point trend, +6569.2% $7M $5M $4M $881.0K $1M $552.0K $314.0K $1M $159.0K $148.0K $104.0K $104.0K
Total Assets 12-point trend, +342.3% $502M $436M $298M $190M $150M $202M $260M $183M $158M $213M $117M $113M
Accounts Payable 12-point trend, +514.7% $19M $16M $11M $11M $4M $6M $2M $1M $4M $6M $3M $3M
Accrued Liabilities 4-point trend, +868.1% · · · · · · · $13M $11M $10M $1M ·
Current Liabilities 12-point trend, +311.4% $89M $78M $50M $66M $53M $28M $22M $18M $18M $19M $8M $22M
Capital Leases 7-point trend, +75.4% $4M $1M $2M $6M $10M $413.0K $2M · · · · ·
Other Non-current Liabilities 5-point trend, -100.0% · · · $0 · · · · $720.0K $779.0K $322.0K $122.0K
Total Liabilities 12-point trend, +534.6% $335M $262M $131M $92M $67M $75M $73M $68M $19M $20M $8M $53M
Long-term Debt 8-point trend, +290.3% $203M $151M $50M $27M $32M $51M $50M $52M · · · ·
Common Stock 12-point trend, +1100.0% $24.0K $24.0K $23.0K $20.0K $13.0K $9.0K $9.0K $6.0K $5.0K $5.0K $3.0K $2.0K
Retained Earnings 12-point trend, -1217.6% $-947M $-885M $-846M $-780M $-713M $-555M $-460M $-366M $-278M $-214M $-101M $-72M
AOCI 10-point trend, +378.9% $198.0K $57.0K $224.0K $-54.0K $-6.0K $-4.0K $20.0K $-38.0K $-47.0K $-71.0K · ·
Stockholders' Equity 12-point trend, +175.1% $167M $173M $167M $98M $83M $126M $187M $116M $139M $193M $109M $61M
Liabilities + Equity 12-point trend, +342.3% $502M $436M $298M $190M $150M $202M $260M $183M $158M $213M $117M $113M
Shares Outstanding 12-point trend, +1214.5% 244,351,501 238,015,825 232,453,190 198,575,016 130,182,535 93,599,975 88,817,741 62,516,627 47,534,979 47,309,422 25,964,886 18,589,245
Cash Flow 16
Annual Cash Flow data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, +919.7% $3M $2M $1M $1M $3M $3M $2M $3M $3M $1M $800.0K $300.0K
Stock-based Comp 12-point trend, +2793.7% $49M $37M $14M $11M $12M $11M $10M $9M $10M $5M $3M $2M
Deferred Tax 8-point trend, +100.0% $0 $0 $0 $0 $0 $0 $0 · $-30.0K · · ·
Restructuring · · · · $6M · · · · · · ·
Other Non-cash 4-point trend, -123.4% $-33M $-45M $-38M $-15M · · · · · · · ·
Operating Cash Flow 12-point trend, -417.1% $-42M $-45M $-90M $-70M $-153M $-81M $-76M $-70M $-65M $-93M $-72M $13M
CapEx 12-point trend, -19.6% $1M $1M $344.0K $55.0K $2M $324.0K $325.0K $311.0K $2M $5M $3M $2M
Investing Cash Flow 11-point trend, -159.4% $-9M $-18M $-131M $18M $51M $-31M $23M $-30M $65M $-131M $-3M ·
Stock Issued 10-point trend, -100.0% $0 $0 $119M $72M $101M $21M $0 · · $191M $74M $61M
Stock Repurchased · · · · · · · · · · · $2.0K
Net Stock Activity 7-point trend, -100.0% $0 $0 $119M $72M $101M · · · · $191M $74M ·
Financing Cash Flow 11-point trend, -27.3% $55M $107M $146M $75M $83M $23M $155M $104M $685.0K $191M $75M ·
Net Change in Cash 12-point trend, -95.8% $3M $43M $-75M $24M $-19M $-90M $102M $3M $785.0K $-32M $-282.0K $73M
Taxes Paid 10-point trend, +602.9% $485.0K $266.0K $51.0K $6.0K $4.0K $1.0K $2.0K $4.0K $3.0K · $69.0K ·
Free Cash Flow 11-point trend, +41.6% $-44M $-46M $-90M $-70M $-154M $-82M $-77M $-71M $-68M $-97M $-75M ·
Levered FCF 6-point trend, -28.2% · · $-95M $-73M $-159M $-87M $-83M $-74M · · · ·
Profitability 8
Annual Profitability data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Gross Margin 3-point trend, +10.8% · · · · · · 88.6% 82.1% 80.0% · · ·
Operating Margin 10-point trend, +91.8% -10.1% -8.4% -50.8% -122.2% -1528.6% -1199.1% -1728.1% -3488.6% -155.0% · -122.3% ·
Net Margin 10-point trend, +87.7% -15.1% -11.7% -53.1% -128.8% -1566.5% -1245.7% -1797.8% -3502.0% -153.2% · -123.3% ·
Pretax Margin 10-point trend, +87.9% -14.9% -11.7% -52.6% -128.8% -1566.4% -1245.7% -1792.0% -3501.9% -150.4% · -123.4% ·
EBITDA Margin 10-point trend, +92.4% -9.3% -7.8% -49.8% -120.0% -1528.6% -1199.1% -1728.1% -3488.6% -155.0% · -122.3% ·
ROA 11-point trend, +48.9% -13.1% -10.7% -27.1% -39.5% -90.0% -40.9% -42.9% -53.5% -34.7% -68.1% -25.7% ·
ROE 11-point trend, -15.1% -40.2% -23.6% -36.9% -81.4% -192.8% -73.3% -80.5% -71.0% -38.7% -74.4% -34.9% ·
ROIC 10-point trend, +7.5% -24.9% -16.2% -38.2% -64.8% -186.8% -72.0% -49.0% -78.5% -47.6% · -27.0% ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -70.3% 4.3 4.6 4.9 2.3 2.5 6.9 11.3 9.9 8.4 10.6 14.5 ·
Quick Ratio 11-point trend, -88.6% 1.6 1.6 0.9 1.6 1.4 3.2 8.2 4.4 4.2 3.9 13.9 ·
Interest Coverage 6-point trend, +50.3% · · -12.8 -18.8 -34.3 -17.8 -15.9 -25.7 · · · ·
Efficiency 3
Annual Efficiency data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 10-point trend, +316.6% 0.9 0.9 0.5 0.3 0.1 0.0 0.0 0.0 0.2 · 0.2 ·
Inventory Turnover 4-point trend, +27.0% 0.4 0.7 0.5 0.3 · · · · · · · ·
Receivables Turnover 5-point trend, -84.4% 6.3 8.4 8.4 12.7 40.2 · · · · · · ·
Per Share 5
Annual Per Share data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, -83.7% $0.68 $0.73 $0.72 $0.50 $0.63 $1.35 $2.10 $1.85 $2.93 $4.08 $4.19 ·
Revenue / Share 5-point trend, +1644.0% $1.69 $1.42 $0.57 $0.33 $0.10 · · · · · · ·
Cash Flow / Share 5-point trend, +88.0% $-0.18 $-0.19 $-0.41 $-0.44 $-1.46 · · · · · · ·
Cash / Share 11-point trend, -93.2% $0.28 $0.27 $0.09 $0.48 $0.56 $0.97 $2.04 $1.26 $1.59 $1.58 $4.12 ·
EPS (TTM) 12-point trend, +89.5% $-0.26 $-0.17 $-0.30 $-0.42 $-1.52 $-1.05 $-1.47 $-1.36 $-1.36 $-1.76 $-1.12 $-2.47
Growth Rates 3
Annual Growth Rates data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -33.8% 22.1% 168.1% 138.6% 416.6% 33.4% · · · · · · ·
Revenue CAGR 3Y 3-point trend, -36.2% 98.4% 220.9% 154.3% · · · · · · · · ·
Revenue CAGR 5Y 121.9% · · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for ARDX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +1188.0% $407M $334M $124M $52M $10M $8M $5M $3M $42M $38M $24M $32M
Net Income TTM 12-point trend, -1816.6% $-62M $-39M $-66M $-67M $-158M $-94M $-95M $-91M $-64M $-112M $-30M $-3M
Market Cap 11-point trend, +202.8% $1.42B $1.21B $1.44B $566M $143M $606M $667M $112M $314M $672M $470M ·
P/E 12-point trend, -193.2% -22.4 -29.8 -20.7 -6.8 -0.7 -6.2 -5.1 -1.3 -4.9 -8.1 -16.2 -7.6
P/S 11-point trend, -82.1% 3.5 3.6 11.6 10.9 14.2 80.0 126.2 42.9 7.5 17.7 19.6 ·
P/B 11-point trend, +97.5% 8.5 7.0 8.6 5.8 1.7 4.8 3.6 1.0 2.3 3.5 4.3 ·
P / Tangible Book 6-point trend, +77.7% 8.5 7.0 8.6 5.8 1.7 4.8 · · · · · ·
P / Cash Flow 11-point trend, -412.0% -33.5 -26.9 -16.1 -8.1 -0.9 -7.4 -8.7 -1.6 -4.8 -7.3 -6.5 ·
P / FCF 11-point trend, -418.4% -32.4 -26.3 -16.0 -8.1 -0.9 -7.4 -8.7 -1.6 -4.6 -6.9 -6.2 ·
Earnings Yield 12-point trend, +65.9% -4.5% -3.4% -4.8% -14.7% -138.2% -16.2% -19.6% -76.0% -20.6% -12.4% -6.2% -13.1%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $407M$334M$124M$52M$10M
Operating Margin % -10.1%-8.4%-50.8%-122.2%-1528.6%
Net Income $-62M$-39M$-66M$-67M$-158M
Diluted EPS $-0.26$-0.17$-0.30$-0.42$-1.52
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 4.34.64.92.32.5
Quick Ratio 1.61.60.91.61.4
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-44M$-46M$-90M$-70M$-154M

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Institutional owners (13F) 272 filers · $726.5M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
50 (+1 vs prior Q) 31 (-1 vs prior Q) 84 (-21 vs prior Q) 84 (+28 vs prior Q) +17.4M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Rubric Capital Management LP $82,633,770 16,202,700 11.37% Shares
MILLENNIUM MANAGEMENT LLC $70,893,942 13,900,773 9.76% Shares
STATE STREET CORP $68,116,253 13,356,128 9.38% Shares
VANGUARD CAPITAL MANAGEMENT LLC $53,404,619 10,471,494 7.35% Shares
JANUS HENDERSON GROUP PLC $49,211,025 8,215,530 6.77% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $48,688,000 9,546,732 6.70% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $40,936,547 8,026,774 5.64% Shares
GEODE CAPITAL MANAGEMENT, LLC $27,984,544 5,485,881 3.85% Shares
TWO SIGMA INVESTMENTS, LP $26,570,097 5,209,823 3.66% Shares
GOLDMAN SACHS GROUP INC $11,716,944 2,297,440 1.61% Shares
Rock Springs Capital Management LP $11,433,022 2,241,769 1.57% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $11,279,976 2,211,760 1.55% Shares
ORACLE INVESTMENT MANAGEMENT INC $10,917,398 1,872,624 1.50% Shares
Qube Research & Technologies Ltd $10,662,443 2,090,675 1.47% Shares
JONES FINANCIAL COMPANIES LLLP $9,800,923 1,765,932 1.35% Shares
VANGUARD FIDUCIARY TRUST CO $8,949,577 1,754,819 1.23% Shares
Eversept Partners, LP $8,559,560 1,678,345 1.18% Shares
J. Goldman & Co LP $8,057,123 1,579,828 1.11% Shares
TWO SIGMA ADVISERS, LP $7,862,921 1,348,700 1.08% Shares
FIRST TRUST ADVISORS LP $6,638,282 1,301,624 0.91% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $6,053,500 1,157,457 0.83% Shares
MORGAN STANLEY $5,612,208 1,100,433 0.77% Shares
CITADEL ADVISORS LLC $5,252,102 1,029,824 0.72% Shares
BlackRock, Inc. $4,905,211 961,806 0.68% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $4,671,789 916,037 0.64% Shares
RENAISSANCE TECHNOLOGIES LLC $4,552,224 892,593 0.63% Shares
PANAGORA ASSET MANAGEMENT INC $4,543,814 890,944 0.63% Shares
BANK OF AMERICA CORP /DE/ $4,414,050 865,500 0.61% Shares
BNP PARIBAS FINANCIAL MARKETS $4,132,642 810,322 0.57% Shares
AIGH Capital Management LLC $3,967,448 777,931 0.55% Shares
ExodusPoint Capital Management, LP $3,839,907 752,923 0.53% Shares
Squarepoint Ops LLC $3,647,836 715,262 0.50% Shares
SECTOR GAMMA AS $3,502,904 686,844 0.48% Shares
Trexquant Investment LP $3,368,989 660,586 0.46% Shares
Redmile Group, LLC $3,272,925 641,750 0.45% Shares
Cubist Systematic Strategies, LLC $3,139,766 569,831 0.43% Shares
MACKENZIE FINANCIAL CORP $2,417,879 474,094 0.33% Shares
Swiss National Bank $2,384,760 467,600 0.33% Shares
HUSSMAN STRATEGIC ADVISORS, INC. $2,142,000 420,000 0.29% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $2,098,069 411,386 0.29% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,033,880 398,800 0.28% Put option
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $1,815,791 303,137 0.25% Shares
Clay Northam Wealth Management, LLC $1,703,987 334,115 0.23% Shares
ALLIANCEBERNSTEIN L.P. $1,585,972 264,770 0.22% Shares
Raiffeisen Bank International AG $1,569,000 300,000 0.22% Shares
RHUMBLINE ADVISERS $1,559,570 305,800 0.21% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,558,560 305,600 0.21% Call option
DIADEMA PARTNERS LP $1,545,428 303,025 0.21% Shares
CITADEL ADVISORS LLC $1,545,300 303,000 0.21% Put option
MILLENNIUM MANAGEMENT LLC $1,530,000 300,000 0.21% Call option
CITIGROUP INC $1,521,549 298,343 0.21% Shares
Y-Intercept (Hong Kong) Ltd $1,480,295 290,254 0.20% Shares
Knott David M Jr $1,342,157 263,168 0.18% Shares
RAYMOND JAMES FINANCIAL INC $1,311,735 257,203 0.18% Shares
Freestone Grove Partners LP $1,293,829 253,692 0.18% Shares
IEQ CAPITAL, LLC $1,228,070 240,798 0.17% Shares
Headlands Technologies LLC $1,228,060 240,796 0.17% Shares
Pekin Hardy Strauss, Inc. $1,154,640 226,400 0.16% Shares
Bank of New York Mellon Corp $1,137,504 223,040 0.16% Shares
LPL Financial LLC $1,074,121 210,612 0.15% Shares
Rafferty Asset Management, LLC $1,051,431 206,163 0.14% Shares
Stonepine Capital Management, LLC $1,050,000 150,000 0.14% Call option
JANE STREET GROUP, LLC $1,049,070 205,700 0.14% Put option
Virtus Investment Advisers, LLC $1,042,302 204,373 0.14% Shares
FRANKLIN RESOURCES INC $1,027,370 201,445 0.14% Shares
Caption Management, LLC $1,020,000 200,000 0.14% Put option
MONIMUS CAPITAL MANAGEMENT, LP $997,616 195,611 0.14% Shares
Carrera Capital Advisors $995,311 195,159 0.14% Shares
Nuveen, LLC $921,106 180,609 0.13% Shares
JANE STREET GROUP, LLC $875,160 171,600 0.12% Call option
Walleye Capital LLC $872,171 171,014 0.12% Shares
VANGUARD ASSET MANAGEMENT, Ltd $849,257 166,521 0.12% Shares
SIMPLEX TRADING, LLC $772,277 151,427 0.11% Shares
Caption Management, LLC $765,000 150,000 0.11% Call option
STATE OF WISCONSIN INVESTMENT BOARD $731,468 143,425 0.10% Shares
MetLife Investment Management, LLC $727,525 142,652 0.10% Shares
CWM, LLC $703,406 117,430 0.10% Shares
PFG Investments, LLC $702,066 137,660 0.10% Shares
Caption Management, LLC $663,000 130,000 0.09% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $659,772 129,367 0.09% Shares
Lion Point Capital, LP $656,115 128,650 0.09% Shares
SECTORAL ASSET MANAGEMENT INC $624,209 122,394 0.09% Shares
Vanguard Global Advisers, LLC $575,810 112,904 0.08% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $574,071 112,563 0.08% Shares
GROUP ONE TRADING LLC $540,105 105,903 0.07% Shares
PROFUND ADVISORS LLC $537,224 105,338 0.07% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $535,102 104,922 0.07% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $527,819 103,494 0.07% Shares
HSBC HOLDINGS PLC $509,286 100,550 0.07% Shares
DIVERSIFIED TRUST CO $495,959 97,247 0.07% Shares
Invesco Ltd. $495,159 97,090 0.07% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $451,825 85,573 0.06% Shares
KORNITZER CAPITAL MANAGEMENT INC /KS $449,009 88,041 0.06% Shares
CITADEL ADVISORS LLC $442,680 86,800 0.06% Call option
BARCLAYS PLC $433,776 85,054 0.06% Shares
PRUDENTIAL FINANCIAL INC $431,919 84,690 0.06% Shares
NATIXIS $398,856 78,207 0.05% Shares
Persistent Asset Partners Ltd $394,592 77,371 0.05% Shares
Arax Advisory Partners $392,348 76,931 0.05% Shares
Balyasny Asset Management L.P. $390,650 76,598 0.05% Shares

Company insiders 43 insiders · 15 officers · 12 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Michael Raab President & CEO July 15, 2026 M 1,678,366 0 9 $-1,557,439
Justin A Renz Chief Financial Officer May 23, 2023 S 336,733 0 0 $0
Mark Kaufmann Chief Financial Officer July 26, 2018 A 151,386 0 0 $0
Reginald Seeto Chief Operating Officer Jan. 16, 2018 A 149,885 0 0 $0
Laura A Williams Chief Patient Officer June 18, 2026 M 378,195 0 1 $-490,569
Robert Ora Felsch SVP Finance and Chief Accounting Officer May 23, 2023 S 116,158 0 0 $0
Robert Blanks Chief Regulatory and Quality Affairs Officer May 23, 2023 S 266,134 0 0 $0
Susan Rodriguez Chief Commercial Officer May 23, 2023 S 353,420 0 0 $0
David P. Rosenbaum Chief Development Officer May 23, 2023 S 112,162 0 0 $0
Elizabeth A Grammer Chief Legal and Administrative Officer May 23, 2023 S 330,451 0 0 $0
Jeremy S Caldwell EVP, Chief Scientific Officer Jan. 16, 2018 A 44,497 0 0 $0
Jeffrey W Jacobs SVP, Technical Operations March 1, 2017 M 68,450 0 0 $0
Paul Korner EVP, Chief Medical Officer Jan. 19, 2017 A 72,608 0 0 $0
Narani Arasaratnam VP, Corporate Controller Jan. 15, 2016 A 1,232 0 0 $0
George Jue VP, Operations March 2, 2015 S 24,134 0 0 $0
Muna Bhanji Director June 16, 2026 A 163,808 0 0 $0
Onaiza Cadoret-Manier Director June 16, 2026 A 178,156 0 0 $0
Merdad Parsey Director June 16, 2026 A 83,746 0 0 $0
Robert B Bazemore Director June 16, 2026 A 68,006 0 0 $0
Richard J Rodgers Director June 16, 2026 A 439,998 0 0 $0
William C Bertrand JR Director June 16, 2026 A 329,507 0 0 $0
David M Mott Director June 16, 2026 A 3,349,655 0 0 $0
Annalisa Jenkins Director June 13, 2018 A 13,399 0 0 $0
Jan M Lundberg Director June 13, 2018 A 11,786 0 0 $0
Gordon Ringold Director June 13, 2018 A 25,000 0 0 $0
Peter G Schultz Director June 11, 2015 A 910,339 0 0 $0
Forest Baskett 10% owner Dec. 15, 2021 S 2,258,850 0 0 $0
Scott D. Sandell 10% owner Dec. 15, 2021 S 2,258,850 0 0 $0
New Enterprise Associates 12, Limited Partnership 10% owner June 10, 2020 J 8,086,401 0 0 $0
Patrick J. Kerins 10% owner June 10, 2020 J 11,324 0 0 $0
NEA 15 GP, LLC 10% owner Dec. 9, 2019 A 3,482,186 0 0 $0
Mohamad Makhzoumi 10% owner Dec. 9, 2019 A 3,482,186 0 0 $0
Anthony A. Florence, Jr. 10% owner Dec. 9, 2019 A 3,482,186 0 0 $0
Peter W. Sonsini 10% owner Dec. 9, 2019 A 3,482,186 0 0 $0
Joshua Makower 10% owner Dec. 9, 2019 A 3,482,186 0 0 $0
Peter J Barris 10% owner Dec. 9, 2019 A 3,482,186 0 0 $0
Jon Sakoda 10% owner May 25, 2018 A 3,082,186 0 0 $0
Ravi Viswanathan 10% owner May 25, 2018 A 3,082,186 0 0 $0
James M Barrett 10% owner May 25, 2018 A 9,169,210 0 0 $0
Harry R Weller 10% owner July 18, 2016 P 2,665,519 0 0 $0
Krishna Kittu Kolluri 10% owner July 18, 2016 P 2,665,519 0 0 $0
Ryan D Drant 10% owner June 5, 2015 P 7,488,893 0 0 $0
John E Bishop May 21, 2026 S 336,845 0 1 $-14,459

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Dec. 29, 2021 Initial filing SEC
New Enterprise Associates 12, Limited Partnership, New Enterprise Associates 15, L.P., NEA 15 Opportunity Fund, L.P., NEA Partners 12, Limited Partnership, NEA Partners 15, L.P., NEA Partners 15-OF, L.P., NEA 12 GP, LLC, NEA 15 GP, LLC, Forest Baskett, Anthony A. Florence, Jr., Patrick J. Kerins, Mohamad H. Makhzoumi, Joshua Makower, Scott D. Sandell, Peter W. Sonsini ×7 filings June 18, 2020 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 37 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBP · ETFis Series Trust I 1.63% 152,393 NS April 30, 2026 N-PORT
PBE · Invesco Exchange-Traded Fund Trust 1.53% 1,387,554 SH Aug. 8, 2026 Daily
LABU · Direxion Shares ETF Trust 0.54% 438,991 NS April 30, 2026 N-PORT
FYC · First Trust Exchange-Traded AlphaDE… 0.47% 779,797 NS April 30, 2026 N-PORT
ESSC · Strategy Shares 0.21% 8,632 NS April 30, 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0.18% 346,769 NS April 30, 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0.10% 72,709 NS April 30, 2026 N-PORT
BIB · ProShares Trust 0.07% 9,066 NS May 31, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.07% 85,753 NS April 30, 2026 N-PORT
TMFX · RBB Fund, Inc. 0.07% 3,899 NS May 31, 2026 N-PORT
IWO · iShares Trust 0.07% 2,201,424 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.07% 262,064 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.07% 13,445 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.04% 1,406,578 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.04% 6,233,216 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.04% 11,276 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.03% 1,166,243 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.02% 111,086 NS April 30, 2026 N-PORT
UWM · ProShares Trust 0.02% 8,820 NS May 31, 2026 N-PORT
ISCG · iShares Trust 0.02% 41,767 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.02% 86,948 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.02% 701,169 SH Aug. 8, 2026 Daily
ISCB · iShares Trust 0.02% 10,655 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 117,949 SH Aug. 8, 2026 Daily
ISCV · iShares Trust 0.02% 23,168 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.02% 8,927 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.01% 14,232 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.01% 2,830,493 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 9,712 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.01% 224 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 92,325 NS May 31, 2026 N-PORT
TILT · FlexShares Trust 0.01% 16,392 NS April 30, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 144,359 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 366,020 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 56,940 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 7,404,867 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 19,726 SH Aug. 8, 2026 Daily