TSHA Taysha Gene Therapies, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$5.28
Price · May 20, 2026
Fundamentals as of May 6, 2026

TSHA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$5.28
Market Cap
$1.57B
P/E (TTM)
-16.2
EPS (TTM)
$-0.34
Revenue (TTM)
$10M
Div Yield
ROE
-44.0%
Debt/Equity
0.2
52W Range
$2 – $7

TSHA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $10M
4-point trend, +290.6%
2022-12-31 2025-12-31
EPS $-0.34
5-point trend, +92.7%
2021-12-31 2025-12-31
Free Cash Flow $-94M
5-point trend, -204.5%
2020-12-31 2025-12-31
Margins -1115.3%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
TSHA
Peer Median
P/E (TTM)
5-point trend, -544.3%
-16.2
P/S (TTM)
3-point trend, +649.0%
160.4
45.5
P/B
5-point trend, +59.2%
6.3
4.8
EV / EBITDA
4-point trend, -505.2%
-11.7
Price / FCF
5-point trend, +48.6%
-16.7

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
TSHA
Peer Median
Operating Margin
3-point trend, -141.2%
-1130.7%
Net Profit Margin
3-point trend, -54.5%
-1115.3%
-237.1%
ROA
5-point trend, +6.6%
-43.3%
-41.6%
ROE
5-point trend, -90.1%
-44.0%
-55.3%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
TSHA
Peer Median
Debt / Equity
4-point trend, -48.0%
0.2
1.0
Current Ratio
5-point trend, -66.2%
12.2
5.7
Quick Ratio
5-point trend, -65.8%
12.0

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
TSHA
Peer Median
Revenue YoY
4-point trend, +290.6%
17.3%
Revenue CAGR 3Y
4-point trend, +290.6%
57.5%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
TSHA
Peer Median
EPS (Diluted)
5-point trend, +92.7%
$-0.34

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
TSHA
Peer Median

TSHA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 20 analysts
  • Strong Buy 6 30.0%
  • Buy 13 65.0%
  • Hold 1 5.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

13 analysts · 2026-05-17
Median target $12.00 +127.5%
Mean target $12.23 +131.9%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.00%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.12 $-0.10 -0.02%
Dec. 31, 2025 $-0.08 $-0.10 0.02%
Sept. 30, 2025 $-0.09 $-0.09 0.00%
June 30, 2025 $-0.09 $-0.08 -0.01%
March 31, 2025 $-0.08 $-0.09 0.01%
Dec. 31, 2024 $-0.07 $-0.08 0.01%

Peer Comparison Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
TSHA $1.57B -16.2 17.3% -1115.3% -44.0%
SLS $577M -15.1 -55.4%
IOVA $1.12B -2.5 60.6% -148.4% -56.0%
INBX $1.15B -8.7 550.0% -10773.5% -365.9%
GLUE $1.03B 63.5% -31.2% -15.4%
ARDX $1.42B -22.4 22.1% -15.1% -40.2%
RXRX $2.16B -2.8 26.9% -863.4% -62.9%
PGEN $1.48B -3.1 146.7% -2588.2% 3159.1%
NVAX $1.09B 2.6 64.7% 39.2% -977.1%
DMRA 38.3% -17981.1% -167.0%
VIR $841M -1.9 -7.6% -638.9% -51.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for TSHA
Metric Trend 2025202420232022
Revenue 4-point trend, +290.6% $10M $8M $15M $3M
R&D Expense 4-point trend, -5.2% $86M $66M $57M $91M
SG&A Expense 4-point trend, -9.3% $34M $29M $30M $37M
Operating Expenses 4-point trend, -27.1% $120M $100M $88M $165M
Operating Income 4-point trend, +32.0% $-110M $-91M $-72M $-162M
Interest Expense 2-point trend, +31.6% · · $5M $4M
Interest Income 3-point trend, +158.2% $9M $7M $4M ·
Other Non-op 4-point trend, -1516.7% $-291.0K $-110.0K $-47.0K $-18.0K
Income Tax Flat — no change across 4 periods $0 $0 $0 $0
Net Income 4-point trend, +34.3% $-109M $-89M $-112M $-166M
EPS (Basic) 4-point trend, +91.0% $-0.34 $-0.36 $-0.96 $-3.78
EPS (Diluted) 4-point trend, +91.0% $-0.34 $-0.36 $-0.96 $-3.78
Shares (Basic) 4-point trend, +627.4% 319,711,972 250,134,421 116,121,482 43,952,015
Shares (Diluted) 4-point trend, +627.4% 319,711,972 250,134,421 116,121,482 43,952,015
EBITDA 3-point trend, -52.5% $-110M $-91M $-72M ·
Balance Sheet 23
Annual Balance Sheet data for TSHA
Metric Trend 2025202420232022
Cash & Equivalents 4-point trend, +263.9% $320M $139M $144M $88M
Prepaid Expense 4-point trend, -48.1% $4M $3M $3M $9M
Other Current Assets 4-point trend, +72.1% $802.0K $308.0K $292.0K $466.0K
Current Assets 4-point trend, +236.7% $325M $142M $150M $96M
PP&E (Net) 4-point trend, -55.0% $7M $7M $11M $15M
PP&E (Gross) 4-point trend, -31.2% $11M $11M $14M $17M
Accum. Depreciation 4-point trend, +185.3% $5M $4M $3M $2M
Other Non-current Assets 4-point trend, -86.1% $183.0K $217.0K $304.0K $1M
Total Assets 4-point trend, +171.9% $343M $160M $173M $126M
Accounts Payable 4-point trend, -42.7% $6M $4M $6M $11M
Current Liabilities 4-point trend, -57.7% $27M $26M $37M $63M
Capital Leases 4-point trend, -11.1% $18M $17M $19M $20M
Other Non-current Liabilities 4-point trend, -62.4% $2M $1M $2M $4M
Total Liabilities 4-point trend, -23.1% $96M $89M $98M $125M
Long-term Debt · · · $38M
Total Debt 3-point trend, +23.7% $50M $44M $41M ·
Common Stock 4-point trend, +200.0% $3.0K $2.0K $2.0K $1.0K
Paid-in Capital 4-point trend, +138.2% $958M $678M $588M $402M
Retained Earnings 4-point trend, -77.2% $-711M $-602M $-513M $-401M
AOCI 2-point trend, +95.2% $-192.0K $-4M · ·
Stockholders' Equity 4-point trend, +25920.9% $247M $72M $75M $949.0K
Liabilities + Equity 4-point trend, +171.9% $343M $160M $173M $126M
Shares Outstanding 4-point trend, +351.0% 285,051,648 204,943,306 186,960,193 63,207,507
Cash Flow 8
Annual Cash Flow data for TSHA
Metric Trend 2025202420232022
Stock-based Comp 4-point trend, -26.3% $13M $13M $8M $18M
Operating Cash Flow 4-point trend, -5.3% $-93M $-81M $-73M $-88M
CapEx 4-point trend, -96.4% $738.0K $374.0K $4M $21M
Investing Cash Flow 4-point trend, +97.6% $-604.0K $-363.0K $-7M $-25M
Stock Issued · · $500.0K ·
Financing Cash Flow 4-point trend, +427.1% $275M $77M $136M $52M
Net Change in Cash 4-point trend, +395.5% $181M $-5M $56M $-61M
Free Cash Flow 3-point trend, -22.0% $-94M $-82M $-77M ·
Profitability 5
Annual Profitability data for TSHA
Metric Trend 2025202420232022
Operating Margin 3-point trend, -141.2% -1130.7% -1097.5% -468.8% ·
Net Margin 3-point trend, -54.5% -1115.3% -1071.6% -722.1% ·
EBITDA Margin 3-point trend, -141.2% -1130.7% -1097.5% -468.8% ·
ROA 3-point trend, +42.0% -43.3% -53.6% -74.6% ·
ROE 3-point trend, +94.9% -44.0% -111.4% -864.1% ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for TSHA
Metric Trend 2025202420232022
Current Ratio 3-point trend, +199.9% 12.2 5.4 4.1 ·
Quick Ratio 3-point trend, +207.5% 12.0 5.3 3.9 ·
Debt / Equity 3-point trend, -62.5% 0.2 0.6 0.5 ·
LT Debt / Equity 3-point trend, -62.5% 0.2 0.6 0.5 ·
Interest Coverage · · -14.5 ·
Efficiency 1
Annual Efficiency data for TSHA
Metric Trend 2025202420232022
Asset Turnover 3-point trend, -62.4% 0.0 0.1 0.1 ·
Per Share 5
Annual Per Share data for TSHA
Metric Trend 2025202420232022
Book Value / Share 3-point trend, +116.1% $0.87 $0.35 $0.40 ·
Revenue / Share 3-point trend, -77.0% $0.03 $0.03 $0.13 ·
Cash Flow / Share 3-point trend, +53.7% $-0.29 $-0.32 $-0.63 ·
Cash / Share 3-point trend, +45.7% $1.12 $0.68 $0.77 ·
EPS (TTM) 4-point trend, +91.0% $-0.34 $-0.36 $-0.96 $-3.78
Growth Rates 2
Annual Growth Rates data for TSHA
Metric Trend 2025202420232022
Revenue YoY 3-point trend, -96.7% 17.3% -46.1% 517.6% ·
Revenue CAGR 3Y 57.5% · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for TSHA
Metric Trend 2025202420232022
Revenue TTM 4-point trend, +290.6% $10M $8M $15M $3M
Net Income TTM 4-point trend, +34.3% $-109M $-89M $-112M $-166M
Market Cap 3-point trend, +373.8% $1.57B $355M $331M ·
Enterprise Value 3-point trend, +470.6% $1.30B $259M $227M ·
P/E 4-point trend, -2605.6% -16.2 -4.8 -1.8 -0.6
P/S 3-point trend, +649.0% 160.4 42.5 21.4 ·
P/B 3-point trend, +43.8% 6.3 5.0 4.4 ·
P / Tangible Book 4-point trend, -95.8% 6.3 5.0 4.4 150.5
P / Cash Flow 3-point trend, -271.6% -16.8 -4.4 -4.5 ·
P / FCF 3-point trend, -288.2% -16.7 -4.3 -4.3 ·
EV / EBITDA 3-point trend, -274.1% -11.7 -2.8 -3.1 ·
EV / FCF 3-point trend, -367.6% -13.8 -3.2 -3.0 ·
EV / Revenue 3-point trend, +802.2% 132.8 31.1 14.7 ·
Earnings Yield 4-point trend, +96.3% -6.2% -20.8% -54.2% -167.3%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $10M$8M$15M$3M
Operating Margin % -1130.7%-1097.5%-468.8%
Net Income $-109M$-89M$-112M$-166M$-175M
Diluted EPS $-0.34$-0.36$-0.96$-3.78$-4.64
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.20.60.50.4
Current Ratio 12.25.44.13.1
Quick Ratio 12.05.33.92.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-94M$-82M$-77M$-132M

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