Sofinnova Investments, Inc.
CIK 1631134 · View on SEC EDGAR ↗
- Portfolio value
- $1.9B
- Positions
- 57
- As of
- June 30, 2026
#1,547 of 9,443 by 13F value · top 16.4%
Portfolio value QoQ: -26.4% 13F does not disclose cash
- Top 10 holdings weight
- 57.89%
- Top 25 holdings weight
- 86.69%
- Positions above 1%
- 26
- Effective number of positions
- 14.3
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 15.52% Est. buys $354,033,331 · sells $1,256,128,391
Median holding: 2.0 quarters Tracked Q4 2024–Q2 2026 · 37.3% still held
- New positions
- 13
- Increased
- 14
- Decreased
- 17
- Closed
- 26
Put-notional exposure: 0.7% puts 13F reports option positions at underlying notional value — may include hedges, not necessarily bearish bets
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- High-conviction bets The holdings this manager is most concentrated in.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Annualized: +48.9% · S&P 500: +18.0%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 98.4% · Options excluded: 10.4%
Sector breakdown
Healthcare
94.7%
Other/Unmapped
5.3%
Full portfolio 57 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| NTRA Natera, Inc. - Common Stock | $420,823,506 | 21.76% | 1,550,280 | $110,783,009 | |||
| VERA Vera Therapeutics, Inc. - Class A Common Stock | $119,889,982 | 6.20% | 2,793,987 | $7,487,885 | |||
| GMAB Genmab A/S - American Depositary Shares | $111,122,056 | 5.74% | 4,045,215 | $90,938,893 | Up ×1 | ||
| JAZZ Jazz Pharmaceuticals plc - Ordinary Shares | $88,036,221 | 4.55% | 365,341 | $-25,077,498 | Down ×2 | ||
| RAPP Rapport Therapeutics, Inc. - Common Stock | $79,356,681 | 4.10% | 1,904,408 | $19,767,755 | |||
| Unknown issuer (CUSIP: 81221K108) | $77,428,998 | 4.00% | 3,564,871 | Up ×1 | |||
| AVBP ArriVent BioPharma, Inc. - Common Stock | $58,945,164 | 3.05% | 1,696,752 | $19,801,095 | |||
| RARE Ultragenyx Pharmaceutical Inc. - Common Stock | $57,347,492 | 2.96% | 1,717,505 | $-8,558,862 | Down ×1 | ||
| BIOA BioAge Labs, Inc. - Common Stock | $56,220,744 | 2.91% | 2,293,788 | $16,102,392 | |||
| BMY Bristol-Myers Squibb Company Common Stock | $50,531,011 | 2.61% | 876,970 | $-70,084,918 | Down ×1 | ||
| SUPN Supernus Pharmaceuticals, Inc. - Common Stock | $48,199,615 | 2.49% | 1,036,328 | $-1,128,617 | Up ×3 | ||
| RYTM Rhythm Pharmaceuticals, Inc. - Common Stock | $45,303,238 | 2.34% | 408,027 | $6,158,389 | Down ×1 | ||
| GILD Gilead Sciences, Inc. - Common Stock | $43,347,254 | 2.24% | 343,100 | ||||
| UTHR United Therapeutics Corporation - Common Stock | $41,444,035 | 2.14% | 76,489 | $-53,474,274 | Down ×1 | ||
| COGT Cogent Biosciences, Inc. - Common Stock | $40,060,228 | 2.07% | 1,035,148 | $-41,290,350 | Down ×1 | ||
| AXSM Axsome Therapeutics, Inc. - Common Stock | $39,268,206 | 2.03% | 160,429 | $3,309,708 | Down ×1 | ||
| IMTX Immatics N.V. - Ordinary Shares | $37,170,475 | 1.92% | 3,669,346 | $1,446,808 | Up ×3 | ||
| DYN Dyne Therapeutics, Inc. - Common Stock | $36,832,709 | 1.90% | 1,658,384 | $7,210,156 | Up ×1 | ||
| IMNM Immunome, Inc. - Common Stock | $36,453,496 | 1.88% | 1,720,316 | $-767,144 | Up ×3 | ||
| IDYA IDEAYA Biosciences, Inc. - Common Stock | $34,479,185 | 1.78% | 925,119 | $-3,231,925 | Down ×1 | ||
| ANAB AnaptysBio, Inc. - Common Stock | $33,313,680 | 1.72% | 493,536 | $19,545,569 | Up ×1 | ||
| NKTR Nektar Therapeutics - Common Stock | $32,933,775 | 1.70% | 471,763 | $-3,728,060 | Down ×1 | ||
| PHVS Pharvaris N.V. - Ordinary Shares | $30,475,319 | 1.58% | 881,299 | $7,357,553 | Up ×4 | ||
| RCUS Arcus Biosciences, Inc. Common Stock | $29,155,623 | 1.51% | 945,690 | $9,216,965 | Up ×1 | ||
| INBX Inhibrx Biosciences, Inc. - Common Stock | $28,719,009 | 1.48% | 303,103 | $1,421,679 | Down ×2 | ||
| BMRN BioMarin Pharmaceutical Inc. - Common Stock | $20,517,261 | 1.06% | 358,568 | $-23,656,902 | Down ×1 | ||
| MANE Veradermics, Incorporated Common Stock | $18,317,199 | 0.95% | 148,993 | $13,687,357 | Up ×1 | ||
| ALC Alcon Inc. Ordinary Shares | $17,165,790 | 0.89% | 255,824 | $-37,837,600 | Down ×1 | ||
| INSM Insmed Incorporated - Common Stock | $16,888,395 | 0.87% | 158,398 | $-39,701,789 | Down ×1 | ||
| RARE Ultragenyx Pharmaceutical Inc. - Common Stock | $16,695,000 | 0.86% | 500,000 | Call option | $9,362,500 | Up ×1 | |
| ISRG Intuitive Surgical, Inc. - Common Stock | $15,907,200 | 0.82% | 40,000 | Call option | Up ×1 | ||
| GMED Globus Medical, Inc. Class A Common Stock | $15,802,000 | 0.82% | 200,000 | Call option | Up ×1 | ||
| EWTX Edgewise Therapeutics, Inc. - Common Stock | $15,476,901 | 0.80% | 380,923 | $3,302,214 | Down ×4 | ||
| EXEL Exelixis, Inc. - Common Stock | $13,831,022 | 0.72% | 254,200 | Put option | $3,044,187 | Up ×1 | |
| NRIX Nurix Therapeutics, Inc. - Common stock | $12,714,617 | 0.66% | 524,098 | Up ×1 | |||
| DSGN Design Therapeutics, Inc. - Common Stock | $12,518,503 | 0.65% | 865,135 | Up ×1 | |||
| DFTX Definium Therapeutics, Inc. - Common Shares | $12,037,677 | 0.62% | 255,903 | $5,532,940 | Down ×1 | ||
| Unknown issuer (CUSIP: 337185102) | $11,371,804 | 0.59% | 565,199 | Up ×1 | |||
| ABT Abbott Laboratories Common Stock | $11,160,839 | 0.58% | 122,998 | Up ×1 | |||
| IRON Disc Medicine, Inc. - Common Stock | $10,695,920 | 0.55% | 146,239 | $5,688,139 | Up ×1 | ||
| TENX Tenax Therapeutics, Inc. - Common Stock | $7,275,567 | 0.38% | 500,039 | $5,606,211 | Up ×1 | ||
| SION Sionna Therapeutics, Inc. - Common Stock | $6,353,564 | 0.33% | 144,432 | Up ×1 | |||
| ABSI Absci Corporation - Common Stock | $3,910,466 | 0.20% | 337,400 | Up ×1 | |||
| MIRM Mirum Pharmaceuticals, Inc. - common stock | $3,230,078 | 0.17% | 27,591 | $681,221 | |||
| JBIO Jade Biosciences, Inc. - Common Stock | $2,386,228 | 0.12% | 107,391 | $877,384 | |||
| SVRA Savara, Inc. - Common Stock | $2,246,940 | 0.12% | 364,763 | $255,334 | |||
| PRAX Praxis Precision Medicines, Inc. - Common Stock | $2,156,048 | 0.11% | 6,440 | $-18,361,011 | Down ×3 | ||
| SEPN Septerna, Inc. - Common Stock | $1,590,976 | 0.08% | 47,506 | $449,407 | |||
| OKUR OnKure Therapeutics, Inc. - Class A Common Stock | $1,466,916 | 0.08% | 321,692 | $880,278 | Up ×1 | ||
| SGMT Sagimet Biosciences Inc. - Series A Common Stock | $1,288,336 | 0.07% | 166,667 | Up ×1 | |||
| WVE Wave Life Sciences Ltd. - Ordinary Shares | $1,099,560 | 0.06% | 189,253 | $-272,524 | |||
| AKTS Aktis Oncology, Inc. - Common stock | $1,045,412 | 0.05% | 32,436 | Up ×1 | |||
| TYRA Tyra Biosciences, Inc. - Common Stock | $1,030,608 | 0.05% | 32,267 | $-6,783,167 | Down ×1 | ||
| BOLT Bolt Biotherapeutics, Inc. - Common Stock | $530,226 | 0.03% | 137,721 | $-26,167 | |||
| NXTC NextCure, Inc. - Common Stock | $356,246 | 0.02% | 222,654 | $-2,021,699 | |||
| IMA ImageneBio, Inc. - Common Stock | $188,116 | 0.01% | 31,884 | $28,696 | |||
| HTFL Heartflow, Inc. - Common Stock | $149,018 | 0.01% | 5,079 | Up ×1 | |||
| No matches | |||||||
Conviction holdings
Positions increased for 3+ consecutive quarters.
Share counts are as reported in 13F filings (not split-adjusted)
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| Unknown issuer (CUSIP: 81221K108) | $77,428,998 | 3,564,871 | 4.00% |
| GILD | $43,347,254 | 343,100 | 2.24% |
| ISRG | $15,907,200 | 40,000 | 0.82% |
| GMED | $15,802,000 | 200,000 | 0.82% |
| NRIX | $12,714,617 | 524,098 | 0.66% |
| DSGN | $12,518,503 | 865,135 | 0.65% |
| Unknown issuer (CUSIP: 337185102) | $11,371,804 | 565,199 | 0.59% |
| ABT | $11,160,839 | 122,998 | 0.58% |
| SION | $6,353,564 | 144,432 | 0.33% |
| ABSI | $3,910,466 | 337,400 | 0.20% |
| SGMT | $1,288,336 | 166,667 | 0.07% |
| AKTS | $1,045,412 | 32,436 | 0.05% |
| HTFL | $149,018 | 5,079 | 0.01% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| NTRA | Price move only | +0 | +$110.8M |
| BMY | Trimmed | -1.1M | -$70.1M |
| UTHR | Trimmed | -84K | -$53.5M |
| COGT | Trimmed | -1.1M | -$41.3M |
| INSM | Trimmed | -188K | -$39.7M |
| ALC | Trimmed | -474K | -$37.8M |
| JAZZ | Trimmed | -233K | -$25.1M |
| BMRN | Trimmed | -423K | -$23.7M |
| AVBP | Price move only | +0 | +$19.8M |
| RAPP | Price move only | +0 | +$19.8M |
1 position hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| IWM | June 30, 2026 | 600,000 | $148,800,000 | No longer tracked |
| GILD | Dec. 31, 2025 | 1,252,312 | $139,006,632 | 18.0% |
| XBI | June 30, 2026 | 1,050,000 | $134,116,500 | No longer tracked |
| SYK | June 30, 2025 | 298,567 | $111,141,566 | -16.4% |
| AZN | June 30, 2026 | 456,031 | $89,938,434 | -12.7% |
| QQQ | June 30, 2026 | 150,000 | $86,577,000 | |
| QQQ | June 30, 2025 | 175,000 | $82,061,000 | |
| IBB | June 30, 2026 | 475,000 | $80,203,750 | 12.4% |
| CELC | June 30, 2026 | 666,175 | $76,037,215 | -11.9% |
| LLY | Sept. 30, 2025 | 97,018 | $75,628,442 | 63.8% |
| VRTX | March 31, 2026 | 164,594 | $74,620,336 | 22.5% |
| ABBV | March 31, 2026 | 317,783 | $72,610,238 | 21.3% |
| ISRG | March 31, 2026 | 126,968 | $71,909,596 | -19.0% |
| LLY | March 31, 2026 | 61,652 | $66,256,171 | 35.9% |
| ABBV | March 31, 2025 | 359,393 | $63,864,136 | 25.9% |
| BSX | Dec. 31, 2025 | 569,427 | $55,593,158 | -48.2% |
| IWM | Sept. 30, 2025 | 250,000 | $53,947,500 | No longer tracked |
| RNA | March 31, 2026 | 745,116 | $53,745,217 | -1.8% |
| MDT | June 30, 2025 | 562,992 | $50,590,461 | 5.7% |
| ALNY | June 30, 2025 | 176,181 | $47,572,394 | -29.5% |
| IBB | Dec. 31, 2025 | 325,000 | $46,920,250 | 26.6% |
| AZN | March 31, 2025 | 651,344 | $42,676,059 | 125.2% |
| BIIB | June 30, 2026 | 229,521 | $42,078,085 | -0.2% |
| APGE | March 31, 2026 | 534,845 | $40,370,101 | 60.2% |
| XBI | Dec. 31, 2025 | 400,000 | $40,080,000 | No longer tracked |
| CDTX | March 31, 2026 | 180,265 | $39,818,736 | No longer tracked |
| GKOS | March 31, 2026 | 288,128 | $32,532,532 | 71.7% |
| BSX | March 31, 2025 | 346,571 | $30,955,722 | -51.0% |
| REPL | Sept. 30, 2025 | 3,306,529 | $30,717,654 | 249.0% |
| BBIO | June 30, 2026 | 409,183 | $30,385,930 | 11.0% |
| CNTA | March 31, 2026 | 1,104,274 | $27,617,893 | No longer tracked |
| ALKS | March 31, 2025 | 894,266 | $25,719,090 | 45.6% |
| DXCM | June 30, 2026 | 393,576 | $24,716,573 | 32.8% |
| BPMC | June 30, 2025 | 261,039 | $23,104,562 | No longer tracked |
| BMY | June 30, 2025 | 371,497 | $22,657,602 | 42.7% |
| AKRO | Dec. 31, 2025 | 473,625 | $22,487,715 | No longer tracked |
| PFE | June 30, 2026 | 800,000 | $22,464,000 | 16.5% |
| INCY | June 30, 2025 | 357,800 | $21,664,790 | 87.3% |
| SRPT | June 30, 2025 | 327,618 | $20,908,581 | 14.4% |
| GMED | March 31, 2025 | 244,700 | $20,239,137 | 16.5% |
| LQDA | June 30, 2026 | 500,000 | $18,870,000 | -12.2% |
| SMMT | Dec. 31, 2025 | 900,000 | $18,594,000 | -25.1% |
| XENE | June 30, 2026 | 305,216 | $17,748,310 | -0.3% |
| INZY | Sept. 30, 2025 | 4,280,308 | $17,121,232 | No longer tracked |
| MRUS | Dec. 31, 2025 | 166,729 | $15,697,535 | No longer tracked |
| SYK | June 30, 2026 | 44,480 | $14,615,683 | 5.0% |
| SNDX | Sept. 30, 2025 | 1,524,440 | $14,276,381 | 28.7% |
| JANX | March 31, 2025 | 253,262 | $13,559,647 | -34.9% |
| CMPX | June 30, 2026 | 2,556,161 | $13,522,092 | 10.3% |
| ROIV | June 30, 2026 | 477,995 | $13,240,462 | 4.6% |
| GEHC | March 31, 2026 | 160,876 | $13,195,050 | 4.0% |
| DHR | June 30, 2025 | 58,606 | $12,014,230 | 8.4% |
| PEN | June 30, 2025 | 42,936 | $11,481,516 | 26.2% |
| PTCT | Dec. 31, 2025 | 186,932 | $11,472,017 | -7.0% |
| EXAS | March 31, 2026 | 101,443 | $10,302,551 | No longer tracked |
| YMAB | Sept. 30, 2025 | 2,194,278 | $9,896,194 | No longer tracked |
| AVTE | June 30, 2025 | 3,758,686 | $9,434,302 | No longer tracked |
| NARI | March 31, 2025 | 180,456 | $9,212,279 | No longer tracked |
| ORIC | June 30, 2026 | 679,578 | $8,610,253 | 29.6% |
| ACAD | June 30, 2025 | 500,000 | $8,305,000 | 34.7% |
| TNGX | June 30, 2026 | 395,081 | $8,265,095 | -23.1% |
| AXGN | June 30, 2026 | 210,665 | $6,979,331 | 0.7% |
| AMLX | March 31, 2026 | 527,099 | $6,367,356 | 192.3% |
| CYTK | June 30, 2026 | 91,791 | $6,049,945 | -9.1% |
| MASI | March 31, 2026 | 46,201 | $6,008,902 | No longer tracked |
| LQDA | Dec. 31, 2025 | 250,000 | $5,685,000 | 103.0% |
| KURA | June 30, 2025 | 791,667 | $5,225,002 | 104.3% |
| ACHV | March 31, 2025 | 1,306,482 | $4,598,817 | 199.6% |
| HRMY | June 30, 2026 | 152,695 | $4,276,987 | 5.7% |
| QURE | March 31, 2026 | 176,513 | $4,223,956 | 202.3% |
| AVTR | March 31, 2025 | 200,000 | $4,214,000 | -12.5% |
| REPL | June 30, 2026 | 512,300 | $3,919,095 | 32.1% |
| EW | March 31, 2025 | 40,000 | $2,961,200 | 23.3% |
| PCVX | June 30, 2026 | 50,600 | $2,940,366 | 7.2% |
| EXAS | March 31, 2025 | 52,042 | $2,924,240 | No longer tracked |
| EVMN | March 31, 2026 | 153,320 | $2,624,838 | -39.0% |
| ERAS | June 30, 2025 | 1,877,085 | $2,571,606 | 1288.2% |
| ESTA | June 30, 2026 | 33,930 | $1,926,545 | -16.8% |
| ACAD | June 30, 2026 | 78,551 | $1,748,545 | 14.9% |
| KROS | March 31, 2025 | 95,375 | $1,509,786 | 7.3% |
| SRRK | Dec. 31, 2025 | 31,410 | $1,169,708 | 25.1% |
| BDX | March 31, 2025 | 4,951 | $1,123,233 | 4.8% |
| MTSR | Sept. 30, 2025 | 36,191 | $1,029,634 | No longer tracked |
| ICUI | March 31, 2025 | 5,000 | $775,850 | 31.7% |
| GPCR | Sept. 30, 2025 | 34,353 | $712,481 | 81.6% |
| ELVN | June 30, 2025 | 33,547 | $660,205 | 195.9% |
| TVTX | March 31, 2025 | 32,616 | $568,171 | 262.6% |
| VIR | June 30, 2025 | 83,010 | $537,905 | 86.7% |
| IKNA | Sept. 30, 2025 | 382,616 | $512,705 | No longer tracked |
| SLNO | June 30, 2026 | 14,689 | $491,788 | No longer tracked |
| LUNG | March 31, 2025 | 61,326 | $416,404 | -65.1% |
| ZYME | June 30, 2026 | 1,610 | $40,314 | 3.5% |