SEPN Septerna, Inc. - Common Stock
$27.41
Price · May 20, 2026
Fundamentals as of May 11, 2026
52W Range
$9–$33
78% of range
Analyst Rating
BUY
14 analysts
Price Target
$44
+61% upside
P/E (TTM)
-25.3
ROE
-12.9%
Net Profit Margin
-106.4%
SEPN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$27.41
Market Cap
$1.25B
P/E (TTM)
-25.3
EPS (TTM)
$-1.10
Revenue (TTM)
$46M
Div Yield
—
ROE
-12.9%
Debt/Equity
—
52W Range
$9 – $33
SEPN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
$46M
2023-12-31
→
2025-12-31
EPS
$-1.10
2023-12-31
→
2025-12-31
Free Cash Flow
$110M
2024-12-31
→
2025-12-31
Margins
-106.4%
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
SEPN
Peer Median
P/E (TTM)
-25.3
22.4
P/S (TTM)
27.2
7.2
P/B
3.3
4.6
Price / FCF
11.4
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
SEPN
Peer Median
Operating Margin
-148.6%
—
Net Profit Margin
-106.4%
-3.9%
ROA
-9.3%
-7.1%
ROE
-12.9%
-18.6%
ROIC
-17.9%
—
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
SEPN
Peer Median
Current Ratio
4.7
3.9
Quick Ratio
4.6
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
SEPN
Peer Median
Revenue YoY
4174.5%
—
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
SEPN
Peer Median
SEPN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
14 analysts
- Strong Buy 3 21.4%
- Buy 10 71.4%
- Hold 1 7.1%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
8 analysts · 2026-05-18
Median
$43.00
← Below all targets
$27.41
Low
$35.00
High
$60.00
Median target
$43.00
+56.9%
Mean target
$44.25
+61.4%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
-0.42%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.19 | $-0.42 | 0.23% |
| Dec. 31, 2025 | $-0.24 | $-0.26 | 0.02% |
| Sept. 30, 2025 | $-0.09 | $0.81 | -0.90% |
| June 30, 2025 | $-0.56 | $0.88 | -1.4% |
| March 31, 2025 | $-0.49 | $-0.46 | -0.03% |
Peer Comparison Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| SEPN | $1.25B | -25.3 | 4174.5% | -106.4% | -12.9% | — |
| MBX | $1.42B | -13.3 | — | — | -29.6% | — |
| AMLX | $1.33B | -7.9 | -77.1% | — | -61.2% | — |
| MAZE | $2.04B | -13.6 | — | — | -598.9% | — |
| PAHC | — | 21.5 | 27.4% | 3.7% | 17.8% | 30.9% |
| HROW | $1.82B | -350.0 | 36.4% | -1.9% | -8.4% | 75.0% |
| COLL | $1.47B | 26.8 | 23.6% | 8.1% | 23.5% | 59.4% |
| EYPT | $1.51B | -5.8 | -27.5% | -739.4% | -84.0% | — |
| XERS | $1.30B | — | 43.7% | 0.19% | -19.7% | — |
| LLY | — | 46.8 | 44.7% | 31.7% | 101.2% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 15
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $46M | $1M | $151.0K | |
| R&D Expense | $98M | $65M | $36M | |
| SG&A Expense | $29M | $17M | $10M | |
| Operating Expenses | $114M | $82M | $-2M | |
| Operating Income | $-68M | $-81M | $2M | |
| Interest Income | $20M | $9M | $3M | |
| Other Non-op | $-100.0K | $-90.0K | $10.0K | |
| Pretax Income | $-49M | $-72M | $-49M | |
| Income Tax | $12.0K | $-498.0K | $691.0K | |
| Net Income | $-49M | $-72M | $4M | |
| EPS (Basic) | $-1.10 | $-7.26 | $0.29 | |
| EPS (Diluted) | $-1.10 | $-7.26 | $0.29 | |
| Shares (Basic) | 44,258,338 | 9,891,126 | 1,928,586 | |
| Shares (Diluted) | 44,258,338 | 9,891,126 | 2,177,124 | |
| EBITDA | $-67M | $-79M | · |
Balance Sheet 23
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $121M | $238M | $88M | |
| Short-term Investments | $270M | $113M | $0 | |
| Receivables | $10M | $171.0K | $151.0K | |
| Prepaid Expense | $10M | $6M | $1M | |
| Other Current Assets | $1M | $239.0K | $92.0K | |
| Current Assets | $411M | $357M | $113M | |
| PP&E (Net) | $4M | $5M | $5M | |
| PP&E (Gross) | $9M | $8M | $6M | |
| Accum. Depreciation | $4M | $3M | $2M | |
| Other Non-current Assets | $816.0K | $267.0K | $97.0K | |
| Total Assets | $596M | $457M | $131M | |
| Accounts Payable | $10M | $3M | $3M | |
| Accrued Liabilities | $12M | $8M | $4M | |
| Current Liabilities | $87M | $13M | $7M | |
| Capital Leases | $21M | $24M | $13M | |
| Other Non-current Liabilities | $0 | $33.0K | $546.0K | |
| Total Liabilities | $214M | $37M | $20M | |
| Common Stock | $45.0K | $44.0K | $3.0K | |
| Retained Earnings | $-167M | $-118M | $-47M | |
| AOCI | $617.0K | $56.0K | $0 | |
| Stockholders' Equity | $382M | $420M | $-38M | |
| Liabilities + Equity | $596M | $457M | $131M | |
| Shares Outstanding | 44,806,272 | 44,422,505 | 3,168,134 |
Cash Flow 11
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $2M | $1M | $800.0K | |
| Stock-based Comp | $8M | $3M | $2M | |
| Deferred Tax | $0 | $-491.0K | $491.0K | |
| Other Non-cash | $149M | $267.0K | · | |
| Operating Cash Flow | $110M | $-67M | $-39M | |
| CapEx | $518.0K | $2M | $3M | |
| Investing Cash Flow | $-229M | $-161M | $22M | |
| Financing Cash Flow | $2M | $378M | $75M | |
| Net Change in Cash | $-117M | $150M | $58M | |
| Taxes Paid | $0 | $232.0K | $75.0K | |
| Free Cash Flow | $110M | $-70M | · |
Profitability 7
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -148.6% | -7518.4% | · | |
| Net Margin | -106.4% | -6678.9% | · | |
| Pretax Margin | -106.3% | -6725.2% | · | |
| EBITDA Margin | -145.2% | -7388.2% | · | |
| ROA | -9.3% | -24.4% | · | |
| ROE | -12.9% | -43.2% | · | |
| ROIC | -17.9% | -19.1% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 4.7 | 27.8 | · | |
| Quick Ratio | 4.6 | 27.3 | · |
Efficiency 2
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.0 | · | |
| Receivables Turnover | 8.7 | 6.7 | · |
Growth Rates 1
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 4174.5% | 611.9% | · |
Valuation (TTM) 10
| Metric | Trend | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $46M | $1M | · | |
| Net Income TTM | $-49M | $-72M | · | |
| Market Cap | $1.25B | $1.02B | · | |
| P/E | -25.3 | -3.2 | · | |
| P/S | 27.2 | 946.3 | · | |
| P/B | 3.3 | 2.4 | · | |
| P / Tangible Book | 3.3 | 2.4 | · | |
| P / Cash Flow | 11.3 | -15.1 | · | |
| P / FCF | 11.4 | -14.6 | · | |
| Earnings Yield | -4.0% | -31.7% | · |
Income Statement 15
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $27M | $24M | $21M | $119.0K | $219.0K | $212.0K | $176.0K | $370.0K | $317.0K | |
| R&D Expense | $30M | $32M | $24M | $22M | $19M | $19M | $18M | $15M | $13M | |
| SG&A Expense | $10M | $8M | $7M | $7M | $7M | $6M | $5M | $3M | $3M | |
| Operating Expenses | $40M | $40M | $19M | $29M | $26M | $25M | $23M | $18M | $16M | |
| Operating Income | $-13M | $-16M | $3M | $-29M | $-26M | $-25M | $-23M | $-18M | $-15M | |
| Interest Income | $5M | $5M | $6M | $4M | $4M | $4M | $2M | $2M | $1M | |
| Other Non-op | $-31.0K | $-41.0K | $-6.0K | $-25.0K | $-28.0K | $-18.0K | $-9.0K | $-15.0K | $-48.0K | |
| Pretax Income | $-8M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| Income Tax | $337.0K | $12.0K | $0 | $0 | $0 | $-564.0K | $-136.0K | $109.0K | $93.0K | |
| Net Income | $-9M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| EPS (Basic) | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| EPS (Diluted) | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| Shares (Basic) | 44,758,800 | -88,187,325 | 44,343,085 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| Shares (Diluted) | 44,758,800 | -89,446,339 | 45,602,099 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| EBITDA | $-13M | · | $3M | $-29M | $-26M | · | $-22M | · | · |
Balance Sheet 23
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $72M | $121M | $320M | $189M | $210M | $238M | $88M | · | · | |
| Short-term Investments | $276M | $270M | $154M | $137M | $126M | $113M | $42M | · | · | |
| Receivables | $11M | $10M | $9M | $151.0K | $250.0K | $171.0K | $210.0K | · | · | |
| Prepaid Expense | $10M | $10M | $9M | $7M | $6M | $6M | $3M | · | · | |
| Other Current Assets | $110.0K | $1M | $387.0K | $0 | $52.0K | $239.0K | $241.0K | · | · | |
| Current Assets | $368M | $411M | $492M | $334M | $342M | $357M | $133M | · | · | |
| PP&E (Net) | $4M | $4M | $4M | $5M | $5M | $5M | $5M | · | · | |
| PP&E (Gross) | $9M | $9M | $8M | $8M | $8M | $8M | $8M | · | · | |
| Accum. Depreciation | $5M | $4M | $4M | $4M | $3M | $3M | $3M | · | · | |
| Other Non-current Assets | $773.0K | $816.0K | $501.0K | $300.0K | $277.0K | $267.0K | $3M | · | · | |
| Total Assets | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Accounts Payable | $7M | $10M | $4M | $7M | $4M | $3M | $6M | · | · | |
| Accrued Liabilities | $9M | $12M | $8M | $7M | $4M | $8M | $6M | · | · | |
| Current Liabilities | $78M | $87M | $75M | $15M | $11M | $13M | $13M | · | · | |
| Capital Leases | $21M | $21M | $22M | $23M | $23M | $24M | $24M | · | · | |
| Other Non-current Liabilities | $100.0K | $0 | $0 | $2.0K | $27.0K | $33.0K | $191.0K | · | · | |
| Total Liabilities | $191M | $214M | $218M | $38M | $34M | $37M | $38M | · | · | |
| Common Stock | $45.0K | $45.0K | $45.0K | $45.0K | $44.0K | $44.0K | $3.0K | · | · | |
| Retained Earnings | $-176M | $-167M | $-157M | $-165M | $-140M | $-118M | $-98M | · | · | |
| AOCI | $-569.0K | $617.0K | $375.0K | $176.0K | $198.0K | $56.0K | $176.0K | · | · | |
| Stockholders' Equity | $378M | $382M | $389M | $378M | $400M | $420M | $-87M | · | · | |
| Liabilities + Equity | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Shares Outstanding | 44,916,572 | 44,806,272 | 44,638,703 | 44,567,891 | 44,448,435 | 44,422,505 | · | · | · |
Cash Flow 11
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $300.0K | $300.0K | |
| Stock-based Comp | $6M | $3M | $3M | $2M | $1M | $1M | $683.0K | $628.0K | $577.0K | |
| Deferred Tax | · | · | · | · | · | $-153.0K | $-136.0K | $-109.0K | $-93.0K | |
| Other Non-cash | $-23M | · | · | · | $-4M | · | · | · | · | |
| Operating Cash Flow | $-26M | $-15M | $169M | $-20M | $-23M | $-21M | $-17M | $-13M | $-17M | |
| CapEx | $832.0K | $65.0K | $13.0K | $58.0K | $382.0K | $612.0K | $578.0K | $149.0K | $764.0K | |
| Investing Cash Flow | $-24M | $-185M | $-38M | $-786.0K | $-5M | $-133M | $-25M | $-12M | $10M | |
| Financing Cash Flow | $333.0K | $1M | $263.0K | $339.0K | $66.0K | $304M | $-1M | · | · | |
| Net Change in Cash | $-49M | $-199M | $131M | $-21M | $-28M | $150M | $-43M | $50M | $-7M | |
| Taxes Paid | · | · | · | · | · | $0 | $75.0K | · | · | |
| Free Cash Flow | $-26M | · | · | · | $-24M | · | · | · | · |
Profitability 7
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -50.1% | · | 12.2% | -24351.3% | -11831.1% | · | -12812.5% | · | · | |
| Net Margin | -32.6% | · | 38.0% | -20872.3% | -9806.4% | · | -11660.8% | · | · | |
| Pretax Margin | -31.3% | · | 38.0% | -20872.3% | -9806.4% | · | -11738.1% | · | · | |
| EBITDA Margin | -48.6% | · | 14.0% | -24015.1% | -11648.4% | · | -12585.2% | · | · | |
| ROA | -1.7% | · | 2.1% | -12.0% | -9.9% | · | -23.5% | · | · | |
| ROE | -2.2% | · | 5.4% | -13.2% | -10.7% | · | 47.0% | · | · | |
| ROIC | -3.7% | · | 0.67% | -7.7% | -6.5% | · | 25.6% | · | · |
Liquidity & Solvency 2
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.7 | · | 6.5 | 22.1 | 32.2 | · | 10.1 | · | · | |
| Quick Ratio | 4.6 | · | 6.4 | 21.6 | 31.6 | · | 9.9 | · | · |
Efficiency 2
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.1 | · | 0.1 | 0.0 | 0.0 | · | 0.0 | · | · | |
| Receivables Turnover | 4.8 | · | 4.9 | 1.6 | 1.8 | · | 1.7 | · | · |
Valuation (TTM) 10
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $48M | · | $22M | $884.0K | $1M | · | $896.0K | · | · | |
| Net Income TTM | $-47M | · | $-59M | $-83M | $-73M | · | $-62M | · | · | |
| Market Cap | $1.08B | · | $840M | $471M | $257M | · | · | · | · | |
| P/E | -22.7 | · | -2.0 | -0.6 | -0.3 | · | · | · | · | |
| P/S | 22.3 | · | 38.2 | 532.9 | 237.9 | · | · | · | · | |
| P/B | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Tangible Book | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Cash Flow | -42.1 | · | · | · | -11.0 | · | · | · | · | |
| P / FCF | -40.8 | · | · | · | -10.8 | · | · | · | · | |
| Earnings Yield | -4.4% | · | -49.3% | -155.9% | -384.6% | · | · | · | · |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Revenue | $46M | $1M | $151.0K |
| Operating Margin % | -148.6% | -7518.4% | — |
| Net Income | $-49M | $-72M | $4M |
| Diluted EPS | $-1.10 | $-7.26 | $0.29 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Current Ratio | 4.7 | 27.8 | — |
| Quick Ratio | 4.6 | 27.3 | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Free Cash Flow | $110M | $-70M | — |
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