SEPN — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234,291,284 | 6,995,858 | 14.22% | Shares |
| TRV GP V, LLC | $208,160,143 | 6,215,591 | 12.64% | Shares |
| Driehaus Capital Management LLC | $148,463,112 | 4,433,058 | 9.01% | Shares |
| TRV GP VI, LLC | $141,048,460 | 4,211,659 | 8.56% | Shares |
| SAMSARA BIOCAPITAL, LLC | $105,464,297 | 3,149,128 | 6.40% | Shares |
| GOLDMAN SACHS GROUP INC | $102,572,033 | 3,062,766 | 6.23% | Shares |
| BlackRock, Inc. | $64,705,629 | 1,932,088 | 3.93% | Shares |
| Siren, L.L.C. | $63,631,000 | 1,900,000 | 3.86% | Shares |
| Avoro Capital Advisors LLC | $44,792,875 | 1,337,500 | 2.72% | Shares |
| VANGUARD GROUP INC | $42,048,476 | 1,508,195 | 2.55% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $40,913,829 | 1,221,673 | 2.48% | Shares |
| PRIMECAP MANAGEMENT CO/CA/ | $39,095,624 | 1,167,382 | 2.37% | Shares |
| First Light Asset Management, LLC | $32,259,577 | 963,260 | 1.96% | Shares |
| ADAR1 Capital Management, LLC | $31,505,617 | 940,747 | 1.91% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $22,750,071 | 679,163 | 1.38% | Shares |
| STATE STREET CORP | $21,856,579 | 652,630 | 1.33% | Shares |
| JANUS HENDERSON GROUP PLC | $21,333,558 | 890,754 | 1.30% | Shares |
| LOOMIS SAYLES & CO L P | $20,922,944 | 624,752 | 1.27% | Shares |
| Casdin Capital, LLC | $18,528,945 | 553,268 | 1.12% | Shares |
| Catalio Capital Management, LP | $17,955,730 | 536,152 | 1.09% | Shares |
| Caption Management, LLC | $14,735,600 | 440,000 | 0.89% | Call option |
| ALGERT GLOBAL LLC | $13,311,840 | 397,487 | 0.81% | Shares |
| Balyasny Asset Management L.P. | $11,736,303 | 350,442 | 0.71% | Shares |
| Longaeva Partners L.P. | $9,985,747 | 298,171 | 0.61% | Shares |
| Soleus Capital Management, L.P. | $9,209,750 | 275,000 | 0.56% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8,774,380 | 262,000 | 0.53% | Call option |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7,708,862 | 230,184 | 0.47% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7,458,290 | 222,702 | 0.45% | Shares |
| TWO SIGMA INVESTMENTS, LP | $7,397,439 | 220,885 | 0.45% | Shares |
| NORTHERN TRUST CORP | $6,735,877 | 201,131 | 0.41% | Shares |
| TUDOR INVESTMENT CORP ET AL | $6,698,000 | 200,000 | 0.41% | Call option |
| Caption Management, LLC | $6,698,000 | 200,000 | 0.41% | Put option |
| Kalehua Capital Management LLC | $6,515,279 | 194,544 | 0.40% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6,264,003 | 187,041 | 0.38% | Shares |
| Woodline Partners LP | $6,213,567 | 185,535 | 0.38% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $5,547,819 | 165,656 | 0.34% | Shares |
| MORGAN STANLEY | $4,500,286 | 134,377 | 0.27% | Shares |
| TUDOR INVESTMENT CORP ET AL | $3,349,000 | 100,000 | 0.20% | Put option |
| UBS Group AG | $3,009,880 | 89,874 | 0.18% | Shares |
| JPMORGAN CHASE & CO | $2,964,211 | 85,301 | 0.18% | Shares |
| FEDERATED HERMES, INC. | $2,905,358 | 86,753 | 0.18% | Shares |
| CITADEL ADVISORS LLC | $2,739,482 | 81,800 | 0.17% | Call option |
| LAZARD ASSET MANAGEMENT LLC | $2,525,983 | 75,425 | 0.15% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $2,522,961 | 75,309 | 0.15% | Shares |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2,499,995 | 74,649 | 0.15% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2,283,348 | 68,180 | 0.14% | Shares |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2,109,870 | 63,000 | 0.13% | Shares |
| AMERICAN CENTURY COMPANIES INC | $2,041,986 | 60,973 | 0.12% | Shares |
| DIADEMA PARTNERS LP | $1,999,353 | 59,700 | 0.12% | Put option |
| JANE STREET GROUP, LLC | $1,915,628 | 57,200 | 0.12% | Call option |
| Bank of New York Mellon Corp | $1,881,334 | 56,176 | 0.11% | Shares |
| XTX Topco Ltd | $1,824,837 | 54,489 | 0.11% | Shares |
| MILLENNIUM MANAGEMENT LLC | $1,693,321 | 50,562 | 0.10% | Shares |
| BARCLAYS PLC | $1,668,506 | 49,821 | 0.10% | Shares |
| Elmind Capital, LP | $1,655,880 | 49,444 | 0.10% | Shares |
| Nuveen, LLC | $1,615,189 | 48,229 | 0.10% | Shares |
| Sofinnova Investments, Inc. | $1,590,976 | 47,506 | 0.10% | Shares |
| D. E. Shaw & Co., Inc. | $1,556,716 | 46,483 | 0.09% | Shares |
| JANE STREET GROUP, LLC | $1,525,537 | 45,552 | 0.09% | Shares |
| Voleon Capital Management LP | $1,488,128 | 44,435 | 0.09% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $1,387,122 | 41,419 | 0.08% | Shares |
| Russell Investments Group, Ltd. | $1,346,606 | 40,209 | 0.08% | Shares |
| Caption Management, LLC | $1,272,821 | 38,006 | 0.08% | Shares |
| BANK OF AMERICA CORP /DE/ | $1,201,453 | 35,875 | 0.07% | Shares |
| Alyeska Investment Group, L.P. | $1,172,150 | 35,000 | 0.07% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,135,311 | 33,900 | 0.07% | Put option |
| Brevan Howard Capital Management LP | $986,347 | 29,452 | 0.06% | Shares |
| HighVista Strategies LLC | $982,496 | 29,337 | 0.06% | Shares |
| TUDOR INVESTMENT CORP ET AL | $970,071 | 28,966 | 0.06% | Shares |
| RHUMBLINE ADVISERS | $925,521 | 27,636 | 0.06% | Shares |
| Trexquant Investment LP | $858,851 | 25,645 | 0.05% | Shares |
| Invesco Ltd. | $806,908 | 24,094 | 0.05% | Shares |
| Logos Global Management LP | $788,623 | 23,548 | 0.05% | Shares |
| FMR LLC | $778,308 | 23,240 | 0.05% | Shares |
| FOX RUN MANAGEMENT, L.L.C. | $738,053 | 22,038 | 0.04% | Shares |
| DEUTSCHE BANK AG\ | $732,527 | 21,873 | 0.04% | Shares |
| ALLIANCEBERNSTEIN L.P. | $718,497 | 29,900 | 0.04% | Shares |
| TWO SIGMA ADVISERS, LP | $716,516 | 25,700 | 0.04% | Shares |
| Squarepoint Ops LLC | $710,624 | 21,219 | 0.04% | Shares |
| STRS OHIO | $703,290 | 21,000 | 0.04% | Shares |
| FRED ALGER MANAGEMENT, LLC | $701,883 | 20,958 | 0.04% | Shares |
| Jump Financial, LLC | $676,498 | 20,200 | 0.04% | Shares |
| Swiss National Bank | $663,102 | 19,800 | 0.04% | Shares |
| WELLS FARGO & COMPANY/MN | $659,218 | 19,684 | 0.04% | Shares |
| FRANKLIN RESOURCES INC | $623,148 | 18,607 | 0.04% | Shares |
| CITIGROUP INC | $596,390 | 17,808 | 0.04% | Shares |
| Aquatic Capital Management LLC | $583,630 | 17,427 | 0.04% | Shares |
| Engineers Gate Manager LP | $581,052 | 17,350 | 0.04% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $567,522 | 16,946 | 0.03% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555,833 | 16,597 | 0.03% | Shares |
| State of Wyoming | $548,533 | 16,379 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $544,112 | 16,247 | 0.03% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $515,646 | 15,397 | 0.03% | Shares |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $445,417 | 13,300 | 0.03% | Shares |
| Verdad Advisers, LP | $434,365 | 12,970 | 0.03% | Shares |
| MetLife Investment Management, LLC | $431,351 | 12,880 | 0.03% | Shares |
| OSAIC HOLDINGS, INC. | $421,772 | 12,594 | 0.03% | Shares |
| Man Group plc | $384,097 | 11,469 | 0.02% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $363,902 | 10,866 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $360,821 | 10,774 | 0.02% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341,364 | 10,193 | 0.02% | Shares |
| Legal & General Group Plc | $336,976 | 10,062 | 0.02% | Shares |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $334,297 | 9,982 | 0.02% | Shares |
| Gotham Asset Management, LLC | $312,194 | 9,322 | 0.02% | Shares |
| Virtus Investment Advisers, LLC | $304,826 | 9,102 | 0.02% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $298,061 | 8,900 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $284,665 | 8,500 | 0.02% | Shares |
| FIRST TRUST ADVISORS LP | $259,179 | 7,739 | 0.02% | Shares |
| Creative Planning | $255,729 | 7,636 | 0.02% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $248,496 | 7,420 | 0.02% | Shares |
| Quantinno Capital Management LP | $245,482 | 7,330 | 0.01% | Shares |
| CIBC Bancorp USA Inc. | $241,865 | 7,222 | 0.01% | Shares |
| Rangeley Capital, LLC | $241,128 | 7,200 | 0.01% | Shares |
| OCCUDO QUANTITATIVE STRATEGIES LP | $240,827 | 7,191 | 0.01% | Shares |
| WINTON GROUP Ltd | $240,525 | 7,182 | 0.01% | Shares |
| Police & Firemen's Retirement System of New Jersey | $218,589 | 6,527 | 0.01% | Shares |
| CITADEL ADVISORS LLC | $212,662 | 6,350 | 0.01% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $211,121 | 6,304 | 0.01% | Shares |
| CAPTRUST FINANCIAL ADVISORS | $208,006 | 6,211 | 0.01% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $204,122 | 6,095 | 0.01% | Shares |
| Chung Wu Investment Group, LLC | $160,752 | 4,800 | 0.01% | Shares |
| Congress Wealth Management LLC / DE / | $133,065 | 12,589 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $130,444 | 3,895 | 0.01% | Shares |
| Lindbrook Capital, LLC | $121,590 | 21,000 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $83,725 | 2,500 | 0.01% | Shares |
| ROYAL BANK OF CANADA | $70,000 | 2,098 | 0.00% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $67,516 | 2,016 | 0.00% | Shares |
| Ameritas Investment Partners, Inc. | $65,105 | 1,944 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $44,374 | 1,325 | 0.00% | Shares |
| GAMMA Investing LLC | $37,475 | 1,119 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $35,466 | 1,059 | 0.00% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $32,519 | 971 | 0.00% | Shares |
| SIGNATUREFD, LLC | $32,351 | 966 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $31,816 | 950 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $25,720 | 768 | 0.00% | Shares |
| CWM, LLC | $21,483 | 894 | 0.00% | Shares |
| Persistent Asset Partners Ltd | $18,207 | 152 | 0.00% | Put option |
| Quantbot Technologies LP | $17,247 | 515 | 0.00% | Shares |
| Amova Asset Management Americas, Inc. | $16,934 | 507 | 0.00% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $12,123 | 362 | 0.00% | Shares |
| Pinnacle Wealth Planning Services, Inc. | $10,784 | 322 | 0.00% | Shares |
| Versant Capital Management, Inc | $10,213 | 261 | 0.00% | Shares |
| Arax Advisory Partners | $7,904 | 236 | 0.00% | Shares |
| US BANCORP \DE\ | $7,368 | 220 | 0.00% | Shares |
| Sterling Capital Management LLC | $6,698 | 200 | 0.00% | Shares |
| Larson Financial Group LLC | $6,564 | 196 | 0.00% | Shares |
| N.E.W. Advisory Services LLC | $6,028 | 180 | 0.00% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $3,725 | 155 | 0.00% | Shares |
| MassMutual Private Wealth & Trust, FSB | $3,483 | 104 | 0.00% | Shares |
| Aster Capital Management (DIFC) Ltd | $3,416 | 102 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $2,579 | 77 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $2,142 | 64 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $1,842 | 55 | 0.00% | Shares |
| Cornerstone Financial Management LLC | $1,741 | 52 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $1,507 | 45 | 0.00% | Shares |
| HRT FINANCIAL LP | $1,407 | 42,022 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1,183 | 35,323 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $1,005 | 30 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $701 | 20,996 | 0.00% | Shares |
| Fortitude Family Office, LLC | $670 | 20 | 0.00% | Shares |
| Ameritas Advisory Services, LLC | $603 | 18 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $234 | 7 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $201 | 6 | 0.00% | Shares |
| Global Retirement Partners, LLC | $100 | 3 | 0.00% | Shares |
| Covestor Ltd | $72 | 2,123 | 0.00% | Shares |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $65 | 1,946 | 0.00% | Shares |
| Allworth Financial LP | $34 | 1 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $33 | 1 | 0.00% | Shares |