TRVI Trevi Therapeutics, Inc. - Common Stock

NASDAQ · Pharmaceuticals · View on SEC EDGAR ↗
$18.42
Price · Aug 18, 2026
Fundamentals as of Aug 6, 2026

TRVI Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$18.41
Market Cap
$2.36B
P/E (TTM)
-57.5
EPS (TTM)
$-0.32
Revenue (TTM)
Div Yield
ROE
-22.4%
Debt/Equity
52W Range
$7 – $20

TRVI Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income
EPS $-0.32
5-point trend, +78.5%
2021-12-31 2025-12-31
Free Cash Flow $-42M
6-point trend, -82.2%
2019-12-31 2025-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
TRVI
Peer Median
P/E (TTM)
5-point trend, -7355.2%
-57.5
29.4
P/B
5-point trend, +571.5%
12.9
6.5
Price / FCF
5-point trend, -2368.0%
-56.1

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
TRVI
Peer Median
ROA
5-point trend, +64.6%
-28.1%
-8.2%
ROE
5-point trend, +90.6%
-22.4%
-19.4%
ROIC
5-point trend, +85.9%
-26.9%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
TRVI
Peer Median
Current Ratio
5-point trend, +559.0%
19.7
3.6
Quick Ratio
5-point trend, +567.2%
19.3

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
TRVI
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
TRVI
Peer Median
EPS (Diluted)
5-point trend, +78.5%
$-0.32

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
TRVI
Peer Median

TRVI Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 18 analysts
  • Strong Buy 6 33.3%
  • Buy 11 61.1%
  • Hold 1 5.6%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

11 analysts · 2026-08-16
Median target $25.00 +35.8%
Mean target $28.18 +53.0%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.02%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.11 $-0.11 0.00%
March 31, 2026 $-0.09 $-0.08 -0.01%
Dec. 31, 2025 $-0.06 $-0.10 0.04%
Sept. 30, 2025 $-0.08 $-0.10 0.02%
June 30, 2025 $-0.09 $-0.10 0.01%
March 31, 2025 $-0.09 $-0.12 0.03%
Dec. 31, 2024 $-0.11 $-0.12 0.01%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
TRVI $1.61B -39.1 -22.4%
ALMS -3.4 -1011.8% -61.9%
AMLX $1.33B -7.9 -77.1% -61.2%
TARS $3.48B -51.5 146.7% -14.7% -19.7%
SUPN $2.86B -73.1 8.6% -5.4% -3.6%
ATAI $223M -1.4 -1.9% -48464.0% -83.1%
NKTR $862M -4.3 -43.9% -297.1% -500.1%
AMRX 57.3 8.1% 2.4% -80.0% 36.9%
PBH $3.33B 15.2 -4.3% 17.5% 10.2% 54.7%
OCUL $2.62B -8.5 -18.5% -511.9% -55.4%
NUVB $3.03B -14.9 699.0% -325.3% -60.3%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for TRVI
Metric Trend 20252024202320222021202020192018
R&D Expense 8-point trend, +137.9% $33M $39M $24M $20M $23M $22M $19M $14M
SG&A Expense 8-point trend, +265.5% $16M $12M $10M $10M $9M $10M $7M $4M
Operating Expenses 8-point trend, +168.0% $49M $52M $34M $30M $32M $32M $27M $18M
Operating Income 8-point trend, -168.0% $-49M $-52M $-34M $-30M $-32M $-32M $-27M $-18M
Interest Expense 5-point trend, +124.7% · · $391.0K $1M $1M $456.0K · $174.0K
Interest Income 3-point trend, +37.7% $7M $4M $5M · · · · ·
Other Non-op 8-point trend, +98.6% $-31.0K $-15.0K $469.0K $289.0K $-375.0K $-287.0K $577.0K $-2M
Pretax Income 8-point trend, -107.2% $-43M $-48M $-29M $-29M $-34M $-33M $-26M $-21M
Income Tax 8-point trend, +48.4% $-64.0K $-30.0K $-32.0K $-36.0K $-21.0K $-18.0K $-18.0K $-124.0K
Net Income 8-point trend, -108.1% $-43M $-48M $-29M $-29M $-34M $-33M $-26M $-21M
EPS (Basic) 5-point trend, +78.5% $-0.32 $-0.47 $-0.29 $-0.45 $-1.49 · · ·
EPS (Diluted) 5-point trend, +78.5% $-0.32 $-0.47 $-0.29 $-0.45 $-1.49 · · ·
Shares (Basic) 5-point trend, +489.9% 134,747,198 101,971,873 99,033,373 64,541,911 22,841,481 · · ·
Shares (Diluted) 5-point trend, +489.9% 134,747,198 101,971,873 99,033,373 64,541,911 22,841,481 · · ·
EBITDA 7-point trend, -84.6% $-49M $-51M $-34M $-30M $-32M $-32M $-27M ·
Balance Sheet 23
Annual Balance Sheet data for TRVI
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, +162.6% $19M $34M $32M $13M $37M $45M $57M $7M
Short-term Investments 4-point trend, +56.9% $169M $74M $51M $108M · · · ·
Prepaid Expense 8-point trend, -12.2% $1M $939.0K $4M $795.0K $886.0K $1M $2M $1M
Other Current Assets 6-point trend, +704.9% $2M $867.0K $955.0K $1M $241.0K $265.0K · ·
Current Assets 8-point trend, +2072.0% $192M $109M $88M $123M $38M $46M $60M $9M
PP&E (Net) 8-point trend, +19.5% $178.0K $157.0K $216.0K $170.0K $53.0K $103.0K $118.0K $149.0K
PP&E (Gross) 8-point trend, +175.4% $537.0K $385.0K $350.0K $395.0K $235.0K $235.0K $203.0K $195.0K
Accum. Depreciation 8-point trend, +680.4% $359.0K $228.0K $134.0K $225.0K $182.0K $132.0K $85.0K $46.0K
Other Non-current Assets 6-point trend, +74.4% $928.0K $243.0K $297.0K $205.0K $334.0K $532.0K · ·
Total Assets 8-point trend, +1737.7% $193M $111M $89M $123M $38M $47M $60M $11M
Accounts Payable 8-point trend, +548.6% $4M $3M $2M $3M $3M $2M $2M $603.0K
Accrued Liabilities 8-point trend, +166.8% $6M $7M $4M $4M $4M $3M $4M $2M
Current Liabilities 8-point trend, +264.3% $10M $11M $6M $13M $13M $6M $5M $3M
Capital Leases 8-point trend, +869.6% $446.0K $747.0K $1M $2.0K $24.0K $144.0K $257.0K $46.0K
Other Non-current Liabilities · · · $3.0K · · · ·
Total Liabilities 6-point trend, -48.6% $10M $11M $7M $16M $21M $20M · ·
Common Stock 8-point trend, +3100.0% $128.0K $94.0K $68.0K $60.0K $29.0K $19.0K $18.0K $4.0K
Paid-in Capital 7-point trend, +203.9% $513M $387M $322M $318M $198M $174M $169M ·
Retained Earnings 8-point trend, -201.2% $-330M $-287M $-239M $-210M $-181M $-147M $-114M $-109M
AOCI 4-point trend, +221.3% $148.0K $61.0K $-29.0K $-122.0K · · · ·
Stockholders' Equity 8-point trend, +267.4% $183M $100M $83M $107M $17M $27M $55M $-109M
Liabilities + Equity 8-point trend, +1737.7% $193M $111M $89M $123M $38M $47M $60M $11M
Shares Outstanding 8-point trend, +29153.5% 128,306,056 93,602,631 68,283,699 59,943,430 28,505,804 18,546,786 17,834,570 438,600
Cash Flow 13
Annual Cash Flow data for TRVI
Metric Trend 20252024202320222021202020192018
D&A 4-point trend, +234.9% $144.0K $147.0K $123.0K $43.0K · · · ·
Stock-based Comp 8-point trend, +945.4% $5M $4M $2M $2M $3M $2M $1M $496.0K
Other Non-cash 3-point trend, +7.1% $-5M $6M $-5M · · · · ·
Operating Cash Flow 8-point trend, -130.1% $-42M $-38M $-32M $-28M $-29M $-29M $-23M $-18M
CapEx 7-point trend, -92.4% $12.0K $35.0K $137.0K $159.0K · $32.0K $9.0K $158.0K
Investing Cash Flow 7-point trend, -59461.4% $-94M $-22M $59M $-107M · $-32.0K $-9.0K $-158.0K
Debt Issued · · · · · $14M · ·
Net Debt Issued 2-point trend, -141.7% · · · $-6M · $14M · ·
Financing Cash Flow 8-point trend, +3234.6% $121M $61M $-8M $111M $21M $17M $73M $4M
Net Change in Cash 8-point trend, -2.5% $-15M $2M $20M $-24M $-8M $-12M $50M $-15M
Taxes Paid 2-point trend, -3.1% $-33.0K $-32.0K · · · · · ·
Free Cash Flow 6-point trend, -82.2% $-42M $-38M $-32M $-28M · $-29M $-23M ·
Levered FCF 3-point trend, -9.3% · · $-32M $-29M · $-29M · ·
Profitability 3
Annual Profitability data for TRVI
Metric Trend 20252024202320222021202020192018
ROA 7-point trend, +62.0% -28.1% -47.8% -27.4% -36.1% -79.3% -61.2% -73.9% ·
ROE 7-point trend, +50.4% -22.4% -60.4% -33.8% -26.8% -238.5% -104.2% -45.2% ·
ROIC 7-point trend, +44.9% -26.9% -51.7% -41.0% -27.8% -190.1% -119.0% -48.8% ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for TRVI
Metric Trend 20252024202320222021202020192018
Current Ratio 7-point trend, +71.6% 19.7 10.4 15.0 9.2 3.0 8.3 11.5 ·
Quick Ratio 7-point trend, +75.2% 19.3 10.2 14.2 9.0 2.9 8.1 11.0 ·
Interest Coverage 4-point trend, -21.8% · · -86.8 -25.7 -27.0 -71.2 · ·
Per Share 4
Annual Per Share data for TRVI
Metric Trend 20252024202320222021202020192018
Book Value / Share 7-point trend, -53.3% $1.43 $1.06 $1.21 $1.79 $0.60 $1.47 $3.06 ·
Cash Flow / Share 4-point trend, +28.4% $-0.31 $-0.38 $-0.32 $-0.44 · · · ·
Cash / Share 7-point trend, -95.4% $0.15 $0.36 $0.47 $0.21 $1.29 $2.43 $3.21 ·
EPS (TTM) 5-point trend, +78.5% $-0.32 $-0.47 $-0.29 $-0.45 $-1.49 · · ·
Valuation (TTM) 8
Annual Valuation (TTM) data for TRVI
Metric Trend 20252024202320222021202020192018
Net Income TTM 7-point trend, -64.1% $-43M $-48M $-29M $-29M $-34M $-33M $-26M ·
Market Cap 7-point trend, +2301.9% $1.61B $386M $92M $116M $22M $45M $67M ·
P/E 5-point trend, -7355.2% -39.1 -8.8 -4.6 -4.3 -0.5 · · ·
P/B 7-point trend, +615.0% 8.8 3.9 1.1 1.1 1.3 1.6 1.2 ·
P / Tangible Book 6-point trend, +432.8% 8.8 3.9 1.1 1.1 1.3 1.6 · ·
P / Cash Flow 7-point trend, -1217.9% -38.2 -10.1 -2.9 -4.1 -0.8 -1.5 -2.9 ·
P / FCF 6-point trend, -1218.0% -38.2 -10.1 -2.9 -4.1 · -1.5 -2.9 ·
Earnings Yield 5-point trend, +98.7% -2.6% -11.4% -21.6% -23.3% -190.5% · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-43M$-48M$-29M$-29M$-34M
Diluted EPS $-0.32$-0.47$-0.29$-0.45$-1.49
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 19.710.415.09.23.0
Quick Ratio 19.310.214.29.02.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-42M$-38M$-32M$-28M

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Institutional owners (13F) 229 filers · $2.5B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
49 (+13 vs prior Q) 18 (-6 vs prior Q) 77 (+12 vs prior Q) 61 (-3 vs prior Q) +17.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
NEA Management Company, LLC $246,594,552 13,222,228 10.04% Shares
FMR LLC $199,426,054 10,693,086 8.12% Shares
Frazier Life Sciences Management, L.P. $185,370,687 9,939,447 7.54% Shares
VANGUARD CAPITAL MANAGEMENT LLC $103,147,089 5,530,675 4.20% Shares
Vivo Capital, LLC $95,015,558 5,094,668 3.87% Shares
Woodline Partners LP $76,116,860 4,081,333 3.10% Shares
WELLINGTON MANAGEMENT GROUP LLP $71,755,577 3,847,484 2.92% Shares
VANGUARD GROUP INC $70,127,888 5,601,269 2.85% Shares
Vestal Point Capital, LP $57,815,000 3,100,000 2.35% Shares
MPM BIOIMPACT LLC $57,322,211 3,073,577 2.33% Shares
FRONTIER CAPITAL MANAGEMENT CO LLC $57,269,301 3,070,740 2.33% Shares
STATE STREET CORP $56,459,425 3,027,315 2.30% Shares
MARSHALL WACE, LLP $49,872,655 2,674,137 2.03% Shares
EVENTIDE ASSET MANAGEMENT, LLC $49,609,000 2,660,000 2.02% Shares
GEODE CAPITAL MANAGEMENT, LLC $46,749,639 2,506,090 1.90% Shares
Rubric Capital Management LP $46,709,167 2,504,513 1.90% Shares
Artia Global Partners LP $41,232,390 2,210,852 1.68% Shares
ACORN CAPITAL ADVISORS, LLC $40,001,341 2,144,844 1.63% Shares
First Light Asset Management, LLC $39,113,060 2,097,215 1.59% Shares
Pictet Asset Management Holding SA $37,557,109 2,013,786 1.53% Shares
Logos Global Management LP $35,062,000 1,880,000 1.43% Shares
Affinity Asset Advisors, LLC $33,573,208 1,800,172 1.37% Shares
EMERALD ADVISERS, LLC $33,525,445 1,797,611 1.36% Shares
Siren, L.L.C. $33,325,070 1,786,867 1.36% Shares
Pivotal bioVenture Partners Investment Advisor LLC $32,500,833 1,742,672 1.32% Shares
VIKING GLOBAL INVESTORS LP $28,807,611 1,544,644 1.17% Shares
Assenagon Asset Management S.A. $28,447,106 1,525,314 1.16% Shares
ALLIANCEBERNSTEIN L.P. $28,100,554 2,355,453 1.14% Shares
BANK OF AMERICA CORP /DE/ $26,936,643 1,444,324 1.10% Shares
ORBIMED ADVISORS LLC $26,674,964 1,430,293 1.09% Shares
Jones Hill Capital LP $24,976,304 1,339,212 1.02% Shares
NAN FUNG TRINITY (HK) LTD $22,634,013 1,213,620 0.92% Shares
EMERALD MUTUAL FUND ADVISERS TRUST $22,584,497 1,210,965 0.92% Shares
Soleus Capital Management, L.P. $21,999,876 1,179,618 0.90% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $21,948,663 1,176,872 0.89% Shares
BARCLAYS PLC $21,199,213 1,136,687 0.86% Shares
GOLDMAN SACHS GROUP INC $19,825,528 1,063,031 0.81% Shares
Saturn V Capital Management LP $19,620,602 1,052,043 0.80% Shares
FLPUTNAM INVESTMENT MANAGEMENT CO $19,359,763 1,038,057 0.79% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $18,138,990 972,600 0.74% Call option
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $18,004,747 965,402 0.73% Shares
Candriam S.C.A. $18,002,647 966,219 0.73% Shares
RAYMOND JAMES FINANCIAL INC $17,533,126 940,114 0.71% Shares
Balyasny Asset Management L.P. $15,760,873 845,087 0.64% Shares
VANGUARD FIDUCIARY TRUST CO $15,685,750 841,059 0.64% Shares
Burkehill Global Management, LP $13,521,250 725,000 0.55% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $12,646,472 678,095 0.51% Shares
AMERIPRISE FINANCIAL INC $11,572,904 620,531 0.47% Shares
SUPERSTRING CAPITAL MANAGEMENT LP $9,776,778 524,224 0.40% Shares
SPHERA FUNDS MANAGEMENT LTD. $9,306,891 499,029 0.38% Shares
PEREGRINE CAPITAL MANAGEMENT LLC $8,286,382 444,310 0.34% Shares
KVP Capital Advisors, LP $7,721,100 414,000 0.31% Shares
Ensign Peak Advisors, Inc $7,388,626 396,173 0.30% Shares
Octagon Capital Advisors LP $5,874,750 315,000 0.24% Shares
Opaleye Management Inc. $5,781,500 310,000 0.24% Shares
BlackRock, Inc. $5,355,515 287,159 0.22% Shares
Informed Momentum Co LLC $4,935,368 264,631 0.20% Shares
FIFTH THIRD BANCORP $4,861,011 260,644 0.20% Shares
Rock Springs Capital Management LP $4,849,000 260,000 0.20% Shares
Trexquant Investment LP $4,523,315 242,537 0.18% Shares
Walleye Capital LLC $4,513,058 241,987 0.18% Shares
F/m Investments LLC $4,367,979 234,208 0.18% Shares
JANE STREET GROUP, LLC $3,761,705 201,700 0.15% Call option
Integral Health Asset Management, LLC $3,730,000 200,000 0.15% Shares
Swiss National Bank $3,586,395 192,300 0.15% Shares
PANAGORA ASSET MANAGEMENT INC $3,398,683 182,235 0.14% Shares
Nuveen, LLC $3,292,602 176,547 0.13% Shares
SEVEN GRAND MANAGERS, LLC $2,797,500 150,000 0.11% Shares
RHUMBLINE ADVISERS $2,470,423 132,463 0.10% Shares
TRUST CO OF TOLEDO NA /OH/ $2,312,637 124,002 0.09% Shares
D. E. Shaw & Co., Inc. $2,286,415 122,596 0.09% Shares
CITADEL ADVISORS LLC $2,170,860 116,400 0.09% Call option
Harvest Investment Services, LLC $2,146,690 115,104 0.09% Shares
WINTON GROUP Ltd $1,992,790 106,852 0.08% Shares
Bank of New York Mellon Corp $1,959,854 105,086 0.08% Shares
Qube Research & Technologies Ltd $1,906,515 102,226 0.08% Shares
LMR Partners LLP $1,865,000 100,000 0.08% Shares
OPPENHEIMER & CO INC $1,860,729 99,771 0.08% Shares
SIMPLEX TRADING, LLC $1,819,438 97,557 0.07% Shares
WEXFORD CAPITAL LP $1,692,525 90,752 0.07% Shares
Erste Asset Management GmbH $1,676,700 90,000 0.07% Shares
STATE OF WISCONSIN INVESTMENT BOARD $1,543,343 82,753 0.06% Shares
Campbell & CO Investment Adviser LLC $1,526,950 81,874 0.06% Shares
J. Goldman & Co LP $1,510,613 80,998 0.06% Shares
PFS Partners, LLC $1,473,350 79,000 0.06% Shares
Schonfeld Strategic Advisors LLC $1,416,838 75,970 0.06% Shares
Checkpoint Capital L.P. $1,398,750 75,000 0.06% Shares
TUDOR INVESTMENT CORP ET AL $1,379,690 73,978 0.06% Shares
VANGUARD ASSET MANAGEMENT, Ltd $1,348,320 72,296 0.05% Shares
CITIGROUP INC $1,329,540 71,289 0.05% Shares
FRED ALGER MANAGEMENT, LLC $1,240,039 66,490 0.05% Shares
SECTORAL ASSET MANAGEMENT INC $1,223,365 65,596 0.05% Shares
Vanguard Global Advisers, LLC $1,198,785 64,278 0.05% Shares
Steward Partners Investment Advisory, LLC $1,186,140 63,600 0.05% Shares
LPL Financial LLC $1,183,324 63,449 0.05% Shares
KENNEDY CAPITAL MANAGEMENT LLC $1,176,964 63,108 0.05% Shares
MetLife Investment Management, LLC $1,165,494 62,493 0.05% Shares
XTX Topco Ltd $1,154,360 61,896 0.05% Shares
WealthTrust Axiom LLC $1,146,975 61,500 0.05% Shares
MAI Capital Management $1,046,825 56,130 0.04% Shares

Company insiders 37 insiders · 13 officers · 9 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Jennifer L Good President & CEO Feb. 19, 2026 A 213,313 0 0 $0
David C Hastings Chief Financial Officer Jan. 8, 2026 A 0 0 $0
Lisa Delfini Chief Financial Officer May 31, 2025 A 64,660 0 0 $0
Christopher Seiter Chief Financial Officer Feb. 17, 2021 A 0 0 $0
Farrell Simon Chief Commercial Officer Feb. 19, 2026 A 76,900 0 0 $0
Christopher Galletta Controller and Principal Accounting Officer Feb. 19, 2026 A 26,095 0 0 $0
James V Cassella Chief Development Officer Feb. 19, 2026 A 0 0 $0
Thomas Sciascia Chief Scientific Officer Feb. 19, 2026 A 221,373 0 0 $0
David J Clark Chief Medical Officer Feb. 15, 2024 A 0 0 $0
William P Forbes Chief Development Officer June 29, 2022 A 0 0 $0
Frank P Muscolo Controller Feb. 17, 2021 A 0 0 $0
Helena Brett-Smith Chief Development Officer Feb. 13, 2020 A 0 0 $0
Yann Mazabraud Chief Commercial Officer and Head of International Feb. 13, 2020 A 0 0 $0
Michael Thomas Heffernan Director June 3, 2026 A 6,351 0 0 $0
David P Meeker Director June 3, 2026 A 352,489 0 0 $0
Edward T. Mathers Director June 3, 2026 A 948,948 0 0 $0
Dominick Colangelo Director June 3, 2026 A 0 0 $0
Anne Vanlent Director June 3, 2026 A 25,983 0 0 $0
Mette Kirstine Agger Director May 9, 2019 C 1,151,544 0 0 $0
Anna Guyer Mitsak Director May 7, 2019 A 0 0 $0
Eran Nadav Director May 7, 2019 A 0 0 $0
Mohamad Makhzoumi 10% owner April 11, 2022 P 948,948 0 0 $0
Ali Behbahani 10% owner April 11, 2022 P 948,948 0 0 $0
Anthony A. Florence, Jr. 10% owner April 11, 2022 P 948,948 0 0 $0
Peter W. Sonsini 10% owner April 11, 2022 P 948,948 0 0 $0
Paul Walker 10% owner April 11, 2022 P 948,948 0 0 $0
Forest Baskett 10% owner April 11, 2022 P 10,421,428 0 0 $0
Scott D. Sandell 10% owner April 11, 2022 P 948,948 0 0 $0
Joshua Makower 10% owner April 3, 2020 X 5,937,998 0 0 $0
Debra A Drake 10% owner May 9, 2019 C 10,399 0 0 $0
Richard King Mellon Foundation 10% owner May 9, 2019 C 347,157 0 0 $0
Lundbeckfond Invest A/S 10% owner May 9, 2019 C 1,151,544 0 0 $0
Peter F Drake 10% owner May 9, 2019 C 62,540 0 0 $0
William J Oshea 10% owner May 9, 2019 C 114,080 0 0 $0
David M Mott 10% owner May 9, 2019 C 4,438,562 0 0 $0
Peter J Barris 10% owner May 9, 2019 C 4,438,562 0 0 $0
Carmen Chang April 11, 2022 P 948,948 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
New Enterprise Associates 16, L.P., NEA Partners 16, L.P., NEA 16 GP, LLC, NEA 18 Venture Growth Equity, L.P., NEA Partners 18 VGE, L.P., NEA 18 VGE GP, LLC, Forest Baskett, Ali Behbahani, Carmen Chang, Anthony A. Florence, Jr., Mohamad H. Makhzoumi, Scott D. Sandell, Paul Walker ×10 filings May 7, 2026 10.50% Amendment Passive investment SEC
Omega Fund V, L.P., Omega Fund V GP, L.P., Omega Fund V GP Manager, Ltd., Richard J. Lim, Claudio Nessi, Anne-Mari Paster, Otello Stampacchia May 20, 2019 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 34 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
LFSC · RBB Fund, Inc. 3.12% 231,602 NS May 31, 2026 N-PORT
PILL · Direxion Shares ETF Trust 1.54% 14,451 NS April 30, 2026 N-PORT
PTH · Invesco Exchange-Traded Fund Trust 1.14% 152,167 SH Aug. 8, 2026 Daily
DWAS · Invesco Exchange-Traded Fund Trust … 0.70% 169,047 SH Aug. 8, 2026 Daily
IHE · iShares Trust 0.48% 421,149 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.18% 7,729 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.14% 148,479 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.13% 680,175 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.12% 965,282 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.12% 114,901 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.09% 4,742 NS May 31, 2026 N-PORT
ISCG · iShares Trust 0.07% 37,042 SH Aug. 8, 2026 Daily
ESML · iShares Trust 0.06% 100,384 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.06% 2,708,707 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.06% 616,796 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.04% 41,397 NS April 30, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.03% 554,292 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.03% 5,335 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.03% 4,499 NS May 31, 2026 N-PORT
VHT · VANGUARD WORLD FUND 0.03% 287,822 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.03% 18,627 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.02% 1,352,952 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.02% 3,519 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.02% 40,477 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.01% 3,558 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.01% 5,160 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 3,851 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.01% 89 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 41,948 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 152,449 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 24,494 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.00% 59,480 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 4,048,595 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 8,874 SH Aug. 8, 2026 Daily