SION — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $435,722,930 | 9,905,045 | 20.30% | Shares |
| TPG GP A, LLC | $285,713,378 | 6,494,962 | 13.31% | Shares |
| VIKING GLOBAL INVESTORS LP | $140,556,012 | 3,195,181 | 6.55% | Shares |
| Atlas Venture Life Science Advisors, LLC | $131,776,532 | 2,995,602 | 6.14% | Shares |
| ORBIMED ADVISORS LLC | $112,433,029 | 2,555,877 | 5.24% | Shares |
| ENAVATE SCIENCES GP, LLC | $109,008,540 | 2,478,030 | 5.08% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $70,384,000 | 1,600,000 | 3.28% | Shares |
| BlackRock, Inc. | $64,875,089 | 1,474,769 | 3.02% | Shares |
| JPMORGAN CHASE & CO | $64,085,673 | 1,490,508 | 2.99% | Shares |
| JENNISON ASSOCIATES LLC | $51,562,131 | 1,172,133 | 2.40% | Shares |
| CITADEL ADVISORS LLC | $50,484,507 | 1,147,636 | 2.35% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $49,796,724 | 1,132,001 | 2.32% | Shares |
| VANGUARD GROUP INC | $48,748,883 | 1,184,951 | 2.27% | Shares |
| STATE STREET CORP | $44,937,281 | 1,021,534 | 2.09% | Shares |
| PERCEPTIVE ADVISORS LLC | $39,810,950 | 905,000 | 1.85% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $29,953,495 | 680,916 | 1.40% | Shares |
| Siren, L.L.C. | $26,856,555 | 610,515 | 1.25% | Shares |
| EVENTIDE ASSET MANAGEMENT, LLC | $20,894,402 | 474,981 | 0.97% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $20,113,984 | 457,145 | 0.94% | Shares |
| Casdin Capital, LLC | $17,596,000 | 400,000 | 0.82% | Shares |
| BAKER BROS. ADVISORS LP | $17,596,000 | 400,000 | 0.82% | Shares |
| GOLDMAN SACHS GROUP INC | $17,103,752 | 388,810 | 0.80% | Shares |
| Driehaus Capital Management LLC | $16,955,814 | 385,447 | 0.79% | Shares |
| FRANKLIN RESOURCES INC | $12,762,071 | 290,113 | 0.59% | Shares |
| Aberdeen Group plc | $12,499,231 | 284,138 | 0.58% | Shares |
| FMR LLC | $12,242,065 | 278,292 | 0.57% | Shares |
| MILLENNIUM MANAGEMENT LLC | $12,173,485 | 276,733 | 0.57% | Shares |
| Candriam S.C.A. | $10,248,950 | 233,208 | 0.48% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $9,807,527 | 222,949 | 0.46% | Shares |
| Kalehua Capital Management LLC | $8,669,197 | 197,072 | 0.40% | Shares |
| Longaeva Partners L.P. | $8,637,524 | 196,352 | 0.40% | Shares |
| Artisan Partners Limited Partnership | $8,336,017 | 189,498 | 0.39% | Shares |
| Ensign Peak Advisors, Inc | $8,117,563 | 184,532 | 0.38% | Shares |
| Soleus Capital Management, L.P. | $7,816,451 | 177,687 | 0.36% | Shares |
| NORTHERN TRUST CORP | $6,795,399 | 154,476 | 0.32% | Shares |
| MORGAN STANLEY | $6,644,558 | 151,047 | 0.31% | Shares |
| Sofinnova Investments, Inc. | $6,353,564 | 144,432 | 0.30% | Shares |
| Qube Research & Technologies Ltd | $6,172,193 | 140,309 | 0.29% | Shares |
| Alyeska Investment Group, L.P. | $5,992,406 | 136,222 | 0.28% | Shares |
| GordonMD Global Investments LP | $5,982,640 | 136,000 | 0.28% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $5,707,834 | 129,753 | 0.27% | Shares |
| Sio Capital Management, LLC | $5,622,274 | 127,808 | 0.26% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $5,342,234 | 121,442 | 0.25% | Shares |
| Artia Global Partners LP | $5,267,407 | 119,741 | 0.25% | Shares |
| UBS Group AG | $5,111,902 | 116,206 | 0.24% | Shares |
| First Turn Management, LLC | $4,860,587 | 110,493 | 0.23% | Shares |
| CITIGROUP INC | $4,846,070 | 110,163 | 0.23% | Shares |
| Ikarian Capital, LLC | $4,728,925 | 107,500 | 0.22% | Put option |
| D. E. Shaw & Co., Inc. | $4,471,320 | 101,644 | 0.21% | Shares |
| Rock Springs Capital Management LP | $4,373,882 | 99,429 | 0.20% | Shares |
| Walleye Capital LLC | $4,282,295 | 97,347 | 0.20% | Shares |
| Rhenman & Partners Asset Management AB | $4,271,429 | 97,100 | 0.20% | Shares |
| BANK OF AMERICA CORP /DE/ | $3,911,063 | 88,908 | 0.18% | Shares |
| AMERIPRISE FINANCIAL INC | $3,617,386 | 82,232 | 0.17% | Shares |
| Integral Health Asset Management, LLC | $3,299,250 | 75,000 | 0.15% | Shares |
| SUPERSTRING CAPITAL MANAGEMENT LP | $2,778,232 | 63,156 | 0.13% | Shares |
| STEMPOINT CAPITAL LP | $2,614,150 | 59,426 | 0.12% | Shares |
| DEUTSCHE BANK AG\ | $2,346,998 | 53,353 | 0.11% | Shares |
| SEVEN GRAND MANAGERS, LLC | $2,199,500 | 50,000 | 0.10% | Shares |
| Point72 Asset Management, L.P. | $2,169,939 | 49,328 | 0.10% | Shares |
| TD Asset Management Inc | $2,084,950 | 47,396 | 0.10% | Shares |
| ALPS ADVISORS INC | $2,002,645 | 45,525 | 0.09% | Shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | $1,868,607 | 42,478 | 0.09% | Shares |
| Russell Investments Group, Ltd. | $1,858,960 | 42,258 | 0.09% | Shares |
| Bank of New York Mellon Corp | $1,829,361 | 41,586 | 0.09% | Shares |
| Nuveen, LLC | $1,814,984 | 41,259 | 0.08% | Shares |
| XTX Topco Ltd | $1,675,843 | 38,096 | 0.08% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $1,643,686 | 37,365 | 0.08% | Shares |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $1,582,232 | 35,968 | 0.07% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1,558,126 | 35,420 | 0.07% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $1,429,675 | 32,500 | 0.07% | Put option |
| BNP PARIBAS FINANCIAL MARKETS | $1,399,014 | 31,803 | 0.07% | Shares |
| Ishara Investments LP | $1,350,540 | 123,000 | 0.06% | Shares |
| MILLENNIUM MANAGEMENT LLC | $1,258,114 | 28,600 | 0.06% | Put option |
| Swiss National Bank | $1,187,730 | 27,000 | 0.06% | Shares |
| Quadrature Capital Ltd | $1,144,752 | 26,023 | 0.05% | Shares |
| Trexquant Investment LP | $1,047,402 | 23,810 | 0.05% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $1,037,548 | 23,586 | 0.05% | Shares |
| ALLIANCEBERNSTEIN L.P. | $1,020,291 | 25,450 | 0.05% | Shares |
| TUDOR INVESTMENT CORP ET AL | $993,074 | 22,575 | 0.05% | Shares |
| RHUMBLINE ADVISERS | $981,362 | 22,309 | 0.05% | Shares |
| MILLENNIUM MANAGEMENT LLC | $879,800 | 20,000 | 0.04% | Call option |
| Maven Securities LTD | $879,800 | 20,000 | 0.04% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $820,193 | 18,645 | 0.04% | Shares |
| Susquehanna Portfolio Strategies, LLC | $793,316 | 18,034 | 0.04% | Shares |
| Rafferty Asset Management, LLC | $791,996 | 18,004 | 0.04% | Shares |
| Shay Capital LLC | $791,820 | 18,000 | 0.04% | Shares |
| WELLS FARGO & COMPANY/MN | $739,955 | 16,821 | 0.03% | Shares |
| Engineers Gate Manager LP | $686,376 | 15,603 | 0.03% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $653,339 | 14,852 | 0.03% | Shares |
| KENNEDY CAPITAL MANAGEMENT LLC | $555,198 | 12,621 | 0.03% | Shares |
| MARSHALL WACE, LLP | $554,230 | 12,599 | 0.03% | Shares |
| Invesco Ltd. | $546,267 | 12,418 | 0.03% | Shares |
| MetLife Investment Management, LLC | $482,658 | 10,972 | 0.02% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $463,369 | 10,582 | 0.02% | Shares |
| Jump Financial, LLC | $460,708 | 10,473 | 0.02% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $419,445 | 9,535 | 0.02% | Shares |
| PROFUND ADVISORS LLC | $402,069 | 9,140 | 0.02% | Shares |
| Virtus Investment Advisers, LLC | $400,705 | 9,109 | 0.02% | Shares |
| Legal & General Group Plc | $397,846 | 9,044 | 0.02% | Shares |
| CITADEL ADVISORS LLC | $369,516 | 8,400 | 0.02% | Put option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $356,319 | 8,100 | 0.02% | Call option |
| Vanguard Global Advisers, LLC | $345,409 | 7,852 | 0.02% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $338,723 | 7,700 | 0.02% | Put option |
| China Universal Asset Management Co., Ltd. | $316,112 | 7,186 | 0.01% | Shares |
| Quarry LP | $296,933 | 6,750 | 0.01% | Shares |
| BARCLAYS PLC | $285,715 | 6,495 | 0.01% | Shares |
| VARCOV Co. | $282,328 | 6,418 | 0.01% | Shares |
| Police & Firemen's Retirement System of New Jersey | $239,218 | 5,438 | 0.01% | Shares |
| Squarepoint Ops LLC | $238,206 | 5,415 | 0.01% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $229,540 | 5,218 | 0.01% | Shares |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $229,408 | 5,215 | 0.01% | Shares |
| SEI INVESTMENTS CO | $226,900 | 5,158 | 0.01% | Shares |
| Verition Fund Management LLC | $219,950 | 5,000 | 0.01% | Call option |
| AlphaCentric Advisors LLC | $213,923 | 4,863 | 0.01% | Shares |
| Jain Global LLC | $210,272 | 4,780 | 0.01% | Shares |
| AXQ CAPITAL, LP | $202,222 | 4,597 | 0.01% | Shares |
| STRS OHIO | $153,965 | 3,500 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $153,525 | 3,490 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $136,369 | 3,100 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $88,816 | 2,019 | 0.00% | Shares |
| Quantbot Technologies LP | $80,062 | 1,820 | 0.00% | Shares |
| Ameritas Investment Partners, Inc. | $73,595 | 1,673 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $56,263 | 1,279 | 0.00% | Shares |
| Mitsubishi UFJ Asset Management Co., Ltd. | $43,990 | 1,000 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $41,615 | 946 | 0.00% | Shares |
| State of Wyoming | $35,368 | 804 | 0.00% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $31,189 | 709 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $25,000 | 568 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $21,029 | 478,016 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $16,936 | 385 | 0.00% | Shares |
| GAMMA Investing LLC | $10,734 | 244 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $9,238 | 210 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $8,622 | 196 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $5,015 | 114 | 0.00% | Shares |
| Hurley Capital, LLC | $4,971 | 113 | 0.00% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4,650 | 116 | 0.00% | Shares |
| US BANCORP \DE\ | $4,575 | 104 | 0.00% | Shares |
| Sterling Capital Management LLC | $2,859 | 65 | 0.00% | Shares |
| CWM, LLC | $2,686 | 67 | 0.00% | Shares |
| Arax Advisory Partners | $1,804 | 41 | 0.00% | Shares |
| Bare Financial Services, Inc | $1,628 | 37 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $1,364 | 31 | 0.00% | Shares |
| Hughes Financial Services, LLC | $1,100 | 25 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $880 | 20 | 0.00% | Shares |
| Fortitude Family Office, LLC | $660 | 15 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $396 | 9 | 0.00% | Shares |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | $264 | 6 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $220 | 5 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $176 | 4 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $88 | 2 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $44 | 1 | 0.00% | Shares |
| Allworth Financial LP | $44 | 1 | 0.00% | Shares |
| Pacer Advisors, Inc. | $13 | 301 | 0.00% | Shares |
| Covestor Ltd | $1 | 12 | 0.00% | Shares |