ACHV Achieve Life Sciences, Inc. - Common Shares

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$7.75
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026
52W Range
$3–$8
99% of range
Analyst Rating
BUY
15 analysts
Price Target
$14
+78% upside
P/E (TTM)
-4.0
ROE
—
Net Profit Margin
—

ACHV Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$7.75
Market Cap
—
P/E (TTM)
-4.0
EPS (TTM)
$-1.25
Revenue (TTM)
—
Div Yield
—
ROE
—
Debt/Equity
—
52W Range
$3 – $8

ACHV Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income —
Flat — no change across 2 periods
2018-12-31 → 2019-12-31
EPS $-1.25
6-point trend, +76.9%
2020-12-31 → 2025-12-31
Free Cash Flow —
5-point trend, +17.6%
2016-12-31 → 2023-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ACHV
Peer Median
P/E (TTM)
5-point trend, -108.5%
-4.0
134.0

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ACHV
Peer Median

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ACHV
Peer Median

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ACHV
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ACHV
Peer Median
EPS (Diluted)
5-point trend, +69.4%
$-1.25
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ACHV
Peer Median

ACHV Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 15 analysts
  • Strong Buy 3 20.0%
  • Buy 11 73.3%
  • Hold 1 6.7%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

12 analysts · 2026-08-16
Median target $12.50 +61.3%
Mean target $13.83 +78.5%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.01%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.19 $-0.31 0.12%
Dec. 31, 2025 $-0.28 $-0.28 -0.00%
Sept. 30, 2025 $-0.28 $-0.26 -0.02%
June 30, 2025 $-0.37 $-0.37 0.00%
March 31, 2025 $-0.37 $-0.37 0.00%
Dec. 31, 2024 $-0.36 $-0.33 -0.03%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ACHV — -4.0 — — — —
RIGL $784M 2.2 64.1% 124.7% 155.1% —
AURA $347M -3.1 -29.7% -1601.4% -68.2% —
MNPR — — — — — —
FDMT $432M -3.1 230194.6% -164.4% -30.2% —
CTMX $725M — -44.8% -22.8% -15.9% —
NGNE $319M -4.9 — — -33.6% —
STTK $231M -5.2 -82.5% -4880.9% -70.0% —
RGNX $733M -3.8 104.5% -113.8% -122.5% —
BBOT $1.00B -2.9 — — -146.2% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 13
Annual Income Statement data for ACHV
Metric Trend 20252024202320222021202020192018
Revenue Flat — no change across 2 periods · · · · · · $0 $0
R&D Expense 7-point trend, +288.8% · $23M $16M $30M $24M $7M $10M $6M
SG&A Expense 7-point trend, +134.0% · $16M $11M $11M $9M $8M $7M $7M
Operating Expenses 8-point trend, +328.3% $55M $39M $27M $41M $33M $15M $17M $13M
Interest Expense 2-point trend, +59.5% · · $3M $2M · · · ·
Interest Income 8-point trend, +774.3% $1M $2M $825.0K $199.0K $17.0K $69.0K $170.0K $171.0K
Other Non-op 8-point trend, +20.0% $-36.0K $-30.0K $-9.0K $40.0K $-75.0K $-49.0K $-37.0K $-45.0K
Pretax Income 8-point trend, -330.7% $-55M $-40M $-30M $-42M $-33M $-15M $-16M $-13M
Net Income 8-point trend, -330.7% $-55M $-40M $-30M $-42M $-33M $-15M $-16M $-13M
EPS (Basic) 6-point trend, +76.9% $-1.25 $-1.24 $-1.50 $-4.00 $-4.08 $-5.42 · ·
EPS (Diluted) 6-point trend, +76.9% $-1.25 $-1.24 $-1.50 $-4.00 $-4.08 $-5.42 · ·
Shares (Basic) 6-point trend, +1503.4% 43,594,652 32,071,146 19,827,534 10,593,034 8,119,836 2,718,909 · ·
Shares (Diluted) 6-point trend, +1503.4% 43,594,652 32,071,146 19,827,534 10,593,034 8,119,836 2,718,909 · ·
Balance Sheet 22
Annual Balance Sheet data for ACHV
Metric Trend 20252024202320222021202020192018
Cash & Equivalents 8-point trend, +120.0% $21M $13M $16M $25M $43M $36M $17M $10M
Short-term Investments 3-point trend, +204.1% $15M $22M · · · · · $5M
Receivables 2-point trend, +14.3% · · · · · · $8.0K $7.0K
Prepaid Expense 7-point trend, +127.5% · $2M $1M $2M $1M $1M $670.0K $926.0K
Current Assets 8-point trend, +156.7% $40M $36M $17M $27M $45M $37M $17M $16M
PP&E (Net) 8-point trend, -91.4% $3.0K $8.0K $13.0K $4.0K $15.0K $42.0K $57.0K $35.0K
PP&E (Gross) 8-point trend, -66.1% $256.0K $256.0K $256.0K $303.0K $302.0K $674.0K $657.0K $755.0K
Accum. Depreciation 8-point trend, -64.9% $253.0K $248.0K $243.0K $299.0K $287.0K $632.0K $600.0K $720.0K
Goodwill Flat — no change across 8 periods $1M $1M $1M $1M $1M $1M $1M $1M
Intangibles 8-point trend, -67.5% $751.0K $974.0K $1M $1M $2M $2M $2M $2M
Other Non-current Assets 3-point trend, +58.5% · · · · · $187.0K $187.0K $118.0K
Total Assets 8-point trend, +119.0% $42M $39M $19M $30M $48M $40M $21M $19M
Accounts Payable 7-point trend, +1254.2% · $2M $618.0K $2M $841.0K $332.0K $859.0K $144.0K
Current Liabilities 8-point trend, +177.7% $9M $7M $21M $22M $5M $3M $3M $3M
Capital Leases 8-point trend, -58.3% $5.0K $66.0K $6.0K $69.0K $4.0K $77.0K $159.0K $12.0K
Total Liabilities 8-point trend, +517.7% $20M $18M $21M $22M $19M $3M $3M $3M
Common Stock 8-point trend, +572.2% $121.0K $103.0K $90.0K $87.0K $79.0K $76.0K $41.0K $18.0K
Retained Earnings 8-point trend, -925.3% $-260M $-206M $-166M $-136M $-94M $-60M $-46M $-25M
AOCI 8-point trend, +150.0% $10.0K $31.0K $4.0K $4.0K $4.0K $4.0K $4.0K $4.0K
Stockholders' Equity 8-point trend, +36.2% $22M $21M $-1M $8M $28M $37M $18M $16M
Liabilities + Equity 8-point trend, +119.0% $42M $39M $19M $30M $48M $40M $21M $19M
Shares Outstanding 8-point trend, +692.0% 53,233,988 34,685,072 21,165,760 17,897,029 9,453,542 6,111,735 1,474,258 6,721,117
Cash Flow 10
Annual Cash Flow data for ACHV
Metric Trend 20252024202320222021202020192018
D&A 6-point trend, -10.6% $228.0K $229.0K $228.0K $236.0K $250.0K $255.0K · ·
Stock-based Comp 8-point trend, +925.9% $9M $5M $3M $3M $2M $1M $1M $854.0K
Amort. of Intangibles Flat — no change across 8 periods $200.0K $200.0K $200.0K $200.0K $200.0K $200.0K $200.0K $200.0K
Operating Cash Flow 8-point trend, -365.6% $-49M $-30M $-24M $-38M $-29M $-13M $-15M $-11M
CapEx 5-point trend, -93.5% $3.0K · $21.0K · · $17.0K $53.0K $46.0K
Investing Cash Flow 6-point trend, +219.2% $6M $-22M $-21.0K · · $-17.0K $5M $-5M
Financing Cash Flow 8-point trend, +160.8% $52M $49M $15M $19M $37M $33M $17M $20M
Net Change in Cash 8-point trend, +103.9% $8M $-3M $-9M $-18M $7M $19M $7M $4M
Taxes Paid Flat — no change across 3 periods $0 $0 $0 · · · · ·
Free Cash Flow 4-point trend, -129.6% · · $-24M · · $-13M $-15M $-11M
Profitability 2
Annual Profitability data for ACHV
Metric Trend 20252024202320222021202020192018
ROA 6-point trend, -56.8% · -137.3% -120.8% · -75.5% -48.0% -81.6% -87.6%
ROE 6-point trend, -79.9% · -152.4% -2302.3% · -105.7% -46.8% -125.2% -84.7%
Liquidity & Solvency 2
Annual Liquidity & Solvency data for ACHV
Metric Trend 20252024202320222021202020192018
Current Ratio 6-point trend, +14.9% · 5.5 0.8 · 9.8 12.6 6.0 4.8
Quick Ratio 6-point trend, +15.1% · 5.1 0.7 · 9.5 12.2 5.8 4.5
Efficiency 2
Annual Efficiency data for ACHV
Metric Trend 20252024202320222021202020192018
Asset Turnover Flat — no change across 2 periods · · · · · · 0.0 0.0
Receivables Turnover Flat — no change across 2 periods · · · · · · 0.0 0.0
Per Share 4
Annual Per Share data for ACHV
Metric Trend 20252024202320222021202020192018
Book Value / Share 6-point trend, -74.4% · $0.60 $-0.07 · $2.97 $6.10 $0.61 $2.35
Cash Flow / Share 2-point trend, +24.8% · $-0.93 $-1.23 · · · · ·
Cash / Share 6-point trend, -74.0% · $0.37 $0.73 · $4.55 $5.87 $0.57 $1.42
EPS (TTM) 6-point trend, +76.9% $-1.25 $-1.24 $-1.50 $-4.00 $-4.08 $-5.42 · ·
Valuation (TTM) 9
Annual Valuation (TTM) data for ACHV
Metric Trend 20252024202320222021202020192018
Revenue TTM Flat — no change across 2 periods · · · · · · $0 $0
Net Income TTM 8-point trend, -330.7% $-55M $-40M $-30M $-42M $-33M $-15M $-16M $-13M
Market Cap 6-point trend, -24.9% · $122M $87M · $74M $50M $313M $163M
P/E 6-point trend, -166.0% -4.0 -2.8 -2.7 -0.6 -1.9 -1.5 · ·
P/B 6-point trend, -43.2% · 5.8 -60.2 · 2.6 1.3 17.3 10.3
P / Tangible Book 5-point trend, +831.3% 13.4 6.5 · 7.5 2.9 1.4 · ·
P / Cash Flow 6-point trend, +73.2% · -4.1 -3.6 · -2.5 -3.7 -20.5 -15.3
P / FCF 4-point trend, +76.7% · · -3.6 · · -3.7 -20.5 -15.2
Earnings Yield 6-point trend, +62.4% -25.1% -35.2% -36.4% -163.3% -52.4% -66.9% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-55M$-40M$-30M$-42M$-33M
Diluted EPS $-1.25$-1.24$-1.50$-4.00$-4.08
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio —5.50.8—9.8
Quick Ratio —5.10.7—9.5
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow ——$-24M——

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Institutional owners (13F) 123 filers · $477.1M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
51 (+34 vs prior Q) 17 (+8 vs prior Q) 37 (+16 vs prior Q) 14 (-8 vs prior Q) +55.5M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Frazier Life Sciences Management, L.P. $49,724,879 7,614,836 10.42% Shares
TPG GP A, LLC $44,910,597 6,877,580 9.41% Shares
venBio Partners LLC $38,623,122 5,914,720 8.10% Shares
Logos Global Management LP $35,425,250 5,425,000 7.43% Shares
FRANKLIN RESOURCES INC $32,344,527 4,953,220 6.78% Shares
Paradigm Biocapital Advisors LP $32,335,620 4,951,856 6.78% Shares
VANGUARD CAPITAL MANAGEMENT LLC $27,039,502 4,140,812 5.67% Shares
Propel Bio Management, LLC $26,342,138 4,034,018 5.52% Shares
STATE STREET CORP $19,234,285 2,945,526 4.03% Shares
Venrock Adviser, LLC $17,964,239 2,751,032 3.77% Shares
Vivo Capital, LLC $17,964,239 2,751,032 3.77% Shares
EVENTIDE ASSET MANAGEMENT, LLC $14,496,600 2,220,000 3.04% Shares
Alyeska Investment Group, L.P. $12,574,965 1,925,722 2.64% Shares
MARSHALL WACE, LLP $11,778,781 1,803,795 2.47% Shares
GEODE CAPITAL MANAGEMENT, LLC $11,492,229 1,759,568 2.41% Shares
Simplify Asset Management Inc. $9,351,646 1,432,105 1.96% Shares
WELLINGTON MANAGEMENT GROUP LLP $9,090,511 1,392,115 1.91% Shares
Caption Management, LLC $7,676,015 1,175,500 1.61% Call option
LPL Financial LLC $5,891,725 902,255 1.23% Shares
Spruce Street Capital LP $4,810,240 736,637 1.01% Shares
VANGUARD FIDUCIARY TRUST CO $3,877,194 593,751 0.81% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,771,075 577,500 0.79% Call option
VANGUARD PORTFOLIO MANAGEMENT LLC $3,510,502 537,596 0.74% Shares
KVP Capital Advisors, LP $3,019,178 462,355 0.63% Shares
TWO SIGMA INVESTMENTS, LP $2,880,951 441,187 0.60% Shares
RAYMOND JAMES FINANCIAL INC $2,741,340 419,807 0.57% Shares
UBS Group AG $1,837,555 281,402 0.39% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,515,861 232,138 0.32% Shares
Caption Management, LLC $1,487,096 227,733 0.31% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $1,483,472 227,178 0.31% Shares
JANE STREET GROUP, LLC $1,331,467 203,900 0.28% Call option
CITADEL ADVISORS LLC $1,326,243 203,100 0.28% Call option
RENAISSANCE TECHNOLOGIES LLC $1,162,660 178,049 0.24% Shares
TWO SIGMA ADVISERS, LP $1,043,203 209,900 0.22% Shares
CITADEL ADVISORS LLC $804,032 123,129 0.17% Shares
CANTOR FITZGERALD, L. P. $794,250 121,631 0.17% Shares
BNP PARIBAS FINANCIAL MARKETS $791,534 121,215 0.17% Shares
BANK OF AMERICA CORP /DE/ $758,727 116,191 0.16% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $677,161 103,700 0.14% Put option
WELLS FARGO & COMPANY/MN $650,564 99,627 0.14% Shares
Shay Capital LLC $606,049 92,810 0.13% Shares
XTX Topco Ltd $587,896 90,030 0.12% Shares
RHUMBLINE ADVISERS $568,253 87,023 0.12% Shares
Blue Trust, Inc. $560,849 85,888 0.12% Shares
Diametric Capital, LP $530,098 81,179 0.11% Shares
CITIGROUP INC $454,632 69,622 0.10% Shares
MANCHESTER FINANCIAL INC $438,666 67,177 0.09% Shares
MEMBERS WEALTH LLC $435,962 66,763 0.09% Shares
Virtus Investment Advisers, LLC $387,066 59,275 0.08% Shares
ADAR1 Capital Management, LLC $351,314 53,800 0.07% Shares
JANE STREET GROUP, LLC $329,197 50,413 0.07% Shares
MetLife Investment Management, LLC $300,282 45,985 0.06% Shares
OSAIC HOLDINGS, INC. $281,540 43,115 0.06% Shares
WINTON GROUP Ltd $277,525 42,500 0.06% Shares
GOLDMAN SACHS GROUP INC $267,573 40,976 0.06% Shares
Bank of New York Mellon Corp $261,559 40,055 0.05% Shares
Rafferty Asset Management, LLC $245,012 37,521 0.05% Shares
BlackRock, Inc. $235,015 35,990 0.05% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $233,062 35,691 0.05% Shares
Next Capital Management LLC $228,517 34,995 0.05% Shares
AMERIFLEX GROUP, INC. $219,395 33,598 0.05% Shares
Vanguard Global Advisers, LLC $211,624 32,408 0.04% Shares
Invesco Ltd. $202,691 31,040 0.04% Shares
JPMORGAN CHASE & CO $201,042 32,270 0.04% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $198,329 30,372 0.04% Shares
Rockefeller Capital Management L.P. $195,900 30,000 0.04% Shares
Jones Hill Capital LP $174,743 26,760 0.04% Shares
BCV Asset Management Inc. $164,591 26,365 0.03% Shares
AXQ CAPITAL, LP $164,380 25,173 0.03% Shares
Nuveen Asset Management, LLC $164,271 46,668 0.03% Shares
Robertson Stephens Wealth Management, LLC $163,250 25,000 0.03% Shares
Keating Financial Advisory Services, Inc. $162,669 24,911 0.03% Shares
Police & Firemen's Retirement System of New Jersey $149,916 22,958 0.03% Shares
ALLIANCEBERNSTEIN L.P. $143,884 48,940 0.03% Shares
Scientech Research LLC $143,706 22,007 0.03% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $134,583 20,610 0.03% Shares
SEI INVESTMENTS CO $133,865 20,500 0.03% Shares
Nuveen, LLC $133,865 20,500 0.03% Shares
PROFUND ADVISORS LLC $129,660 19,856 0.03% Shares
NEW YORK STATE COMMON RETIREMENT FUND $125,376 19,200 0.03% Shares
nVerses Capital, LLC $118,852 18,201 0.02% Shares
VANGUARD GROUP INC $112,337 22,603 0.02% Shares
Cubist Systematic Strategies, LLC $111,898 35,523 0.02% Shares
MAGNOLIA CAPITAL ADVISORS LLC $98,603 15,100 0.02% Shares
VOYA INVESTMENT MANAGEMENT LLC $96,931 14,844 0.02% Shares
SBI Securities Co., Ltd. $96,912 14,841 0.02% Shares
INTECH INVESTMENT MANAGEMENT LLC $89,696 13,736 0.02% Shares
StoneX Group Inc. $86,507 16,342 0.02% Shares
PRUDENTIAL FINANCIAL INC $85,151 13,040 0.02% Shares
Alpine Global Management, LLC $81,625 12,500 0.02% Shares
NORTHERN TRUST CORP $79,790 12,219 0.02% Shares
Windsor Capital Management, LLC $70,635 10,817 0.01% Shares
BARCLAYS PLC $66,861 10,239 0.01% Shares
ProShare Advisors LLC $66,554 10,192 0.01% Shares
Legal & General Group Plc $49,334 7,555 0.01% Shares
Ameritas Investment Partners, Inc. $46,128 7,064 0.01% Shares
FMR LLC $41,211 6,311 0.01% Shares
Russell Investments Group, Ltd. $40,642 6,224 0.01% Shares
Point72 Asia (Singapore) Pte. Ltd. $23,641 7,505 0.00% Shares
Allworth Financial LP $19,590 3,000 0.00% Shares

Company insiders 48 insiders · 17 officers · 26 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Andrew D. Goldberg CEO and President April 18, 2026 A — 0 0 $0
John Bencich CEO Aug. 16, 2024 A 100,636 0 0 $0
Mark K Oki Chief Financial Officer Jan. 28, 2026 A 127,940 0 1 $-146,175
Michelle Renee Griffin CFO May 8, 2012 A — 0 0 $0
Stephen Charles Anderson CFO and Secretary Dec. 31, 2009 A 10,000 0 0 $0
Alan Fuhrman Senior Vice President & CFO March 18, 2008 A — 0 0 $0
Cindy Jacobs President & CMO Sept. 4, 2025 M 115,585 0 1 $-76,532
Mark Lawrence Rubinstein Chief Medical Officer Jan. 28, 2026 A — 0 0 $0
Craig Donnelly Chief Operations Officer Jan. 28, 2026 A — 0 0 $0
Jaime Xinos Chief Commercial Officer Jan. 28, 2026 A 74,432 0 1 $-57,766
Jerry Wann Principal Accounting Officer Jan. 28, 2026 A 32,694 0 1 $-38,974
Erik Atkisson Chief Legal Officer Dec. 4, 2025 A — 0 0 $0
Anthony Clarke CSO April 28, 2022 M 3,502 0 0 $0
Susan D. Wyrick PAO March 14, 2014 A 1,312 0 0 $0
Cameron William Lawrence Principal Accounting Officer May 8, 2012 A 950 0 0 $0
Craig Steven Eudy Principal Accounting Officer Dec. 29, 2006 A — 0 0 $0
Michael B Stewart Sr. VP & Chief Medical Officer Dec. 16, 2005 A — 0 0 $0
Reid Alexander Waldman Director July 27, 2026 A — 0 0 $0
Christopher Nathan Martin Director July 27, 2026 A — 0 0 $0
Thomas Sellig Director July 27, 2026 A — 0 0 $0
Nancy R. Phelan Director July 27, 2026 A — 0 0 $0
Aaron Royston Director July 27, 2026 A — 0 0 $0
Richard Alistair Stewart Director July 27, 2026 A 228,875 0 1 $-378,143
Jeffrey S Farrow Director July 27, 2026 A — 0 0 $0
Thomas Braxton King Director Sept. 4, 2025 M 315,142 0 1 $-387,407
Kristen B. Slaoui Director June 6, 2025 A — 0 0 $0
Stuart Duty Director June 6, 2025 A — 0 0 $0
Bridget A Martell Director June 6, 2025 A — 0 0 $0
Vaughn B Himes Director Jan. 22, 2024 A — 0 0 $0
Donald Joseph Director May 31, 2022 A — 0 0 $0
Martin A Mattingly Director May 31, 2022 A 10,500 0 0 $0
Jay M Moyes Director May 31, 2022 A — 0 0 $0
Scott Daniel Cormack Director May 12, 2020 A 14,810 0 0 $0
PARKER H STEWART Director May 12, 2020 A 12,500 0 0 $0
Neil James Clendeninn Director May 26, 2016 A 22,421 0 0 $0
Jack Goldstein Director May 26, 2016 A 17,500 0 0 $0
David V Smith Director May 26, 2016 A 9,500 0 0 $0
Dwight Winstead Director May 17, 2010 M 0 0 0 $0
Patrick Robert Brady Director May 12, 2009 A — 0 0 $0
Robert E Ivy Director May 18, 2007 M 1,700 0 0 $0
George W Dunbar JR Director May 10, 2007 A 3,250 0 0 $0
VENTURES WEST CAPITAL LTD 10% owner Dec. 15, 2008 S 41,763 0 0 $0
SAC CAPITAL ADVISORS LLC 10% owner Feb. 19, 2004 P 1,419,752 0 0 $0
SAC CAPITAL ASSOCIATES LLC 10% owner Feb. 19, 2004 P 867,376 0 0 $0
S A C CAPITAL MANAGEMENT L L C 10% owner Feb. 19, 2004 P 1,419,752 0 0 $0
Steven A. Cohen 10% owner Feb. 19, 2004 P 1,419,752 0 0 $0
Michael A Martino — July 6, 2010 M 11,000 0 0 $0
Richard J Klein — Dec. 29, 2003 A — 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 9 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
venBio Global Strategic Fund V, L.P., venBio Global Strategic GP V, LLC April 27, 2026 9.99% Initial filing Passive investment SEC
TPG GP A, LLC, James G. Coulter, Jon Winkelried April 24, 2026 12.60% Initial filing — SEC
Dialectic Capital Management, LP, Dialectic Partners, LLC, Dialectic Life Sciences SPV LLC, Dialectic LS Manager LLC, John Fichthorn ×3 filings March 23, 2023 — Initial filing — SEC
Anthony Clarke Aug. 11, 2017 — Initial filing Passive investment SEC
Richard Stewart Aug. 11, 2017 — Initial filing Passive investment SEC
Working Opportunity Fund (EVCC) Ltd., GrowthWorks Capital Ltd. ×5 filings Feb. 14, 2011 — Initial filing — SEC
Oct. 28, 2010 — Initial filing — SEC
Abingworth LLP Aug. 20, 2010 — Initial filing Passive investment SEC
SCHERING BERLIN VENTURE CORPORATION, SCHERING BERLIN INC., SCHERING INTERNATIONAL HOLDING GmbH, SCHERING AKTIENGESELLSCHAFT Oct. 31, 2005 — Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 9 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.12% 263,891 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.03% 713,270 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.03% 83,121 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.02% 447,963 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.02% 1,953,101 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.01% 957,103 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 31,465 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 3,108,369 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 6,512 SH Aug. 8, 2026 Daily