IPSC — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $43,498,354 | 17,754,430 | 11.14% | Shares |
| TCG Crossover Management, LLC | $43,401,690 | 17,754,430 | 11.12% | Shares |
| Versant Venture Management, LLC | $29,806,967 | 12,166,109 | 7.63% | Shares |
| Deep Track Capital, LP | $23,183,480 | 9,462,645 | 5.94% | Shares |
| RTW INVESTMENTS, LP | $21,304,347 | 8,695,652 | 5.46% | Shares |
| Venrock Adviser, LLC | $21,304,347 | 8,695,652 | 5.46% | Shares |
| Commodore Capital LP | $21,304,347 | 8,695,652 | 5.46% | Shares |
| BlackRock, Inc. | $19,824,831 | 8,091,768 | 5.08% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $13,974,016 | 5,703,680 | 3.58% | Shares |
| Balyasny Asset Management L.P. | $13,531,213 | 5,522,944 | 3.47% | Shares |
| Point72 Asset Management, L.P. | $12,202,289 | 4,980,526 | 3.13% | Shares |
| Seven Fleet Capital Management LP | $10,652,174 | 4,347,826 | 2.73% | Shares |
| Woodline Partners LP | $10,430,948 | 4,257,530 | 2.67% | Shares |
| MILLENNIUM MANAGEMENT LLC | $10,277,703 | 4,194,981 | 2.63% | Shares |
| Trails Edge Capital Partners, LP | $10,130,674 | 4,134,969 | 2.59% | Shares |
| Spruce Street Capital LP | $9,944,682 | 4,059,054 | 2.55% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $9,284,368 | 3,789,538 | 2.38% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $7,301,590 | 2,979,529 | 1.87% | Shares |
| TWO SIGMA INVESTMENTS, LP | $6,612,582 | 2,699,013 | 1.69% | Shares |
| DAFNA Capital Management LLC | $5,881,122 | 2,400,458 | 1.51% | Shares |
| STEMPOINT CAPITAL LP | $5,258,146 | 2,146,182 | 1.35% | Shares |
| STATE STREET CORP | $4,515,727 | 1,843,154 | 1.16% | Shares |
| NORTHERN TRUST CORP | $3,905,163 | 1,593,944 | 1.00% | Shares |
| DV Trading LLC | $3,430,000 | 1,400,000 | 0.88% | Shares |
| Rock Springs Capital Management LP | $3,195,650 | 1,304,347 | 0.82% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $3,081,365 | 1,257,700 | 0.79% | Shares |
| Casdin Capital, LLC | $3,009,066 | 1,228,190 | 0.77% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2,487,688 | 1,015,383 | 0.64% | Shares |
| VANGUARD GROUP INC | $2,093,350 | 2,103,869 | 0.54% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $1,806,929 | 737,522 | 0.46% | Shares |
| MARSHALL WACE, LLP | $1,318,085 | 537,994 | 0.34% | Shares |
| TWO SIGMA ADVISERS, LP | $1,261,108 | 1,267,700 | 0.32% | Shares |
| Invesco Ltd. | $934,477 | 381,419 | 0.24% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $928,224 | 378,867 | 0.24% | Shares |
| Bank of New York Mellon Corp | $732,584 | 299,014 | 0.19% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $664,720 | 271,492 | 0.17% | Shares |
| UBS Group AG | $569,402 | 232,409 | 0.15% | Shares |
| AMERICAN CENTURY COMPANIES INC | $426,452 | 174,062 | 0.11% | Shares |
| Nuveen, LLC | $400,800 | 163,592 | 0.10% | Shares |
| BANK OF AMERICA CORP /DE/ | $389,288 | 158,893 | 0.10% | Shares |
| GOLDMAN SACHS GROUP INC | $368,561 | 150,433 | 0.09% | Shares |
| WELLS FARGO & COMPANY/MN | $364,842 | 148,915 | 0.09% | Shares |
| RHUMBLINE ADVISERS | $314,584 | 128,404 | 0.08% | Shares |
| CITADEL ADVISORS LLC | $309,852 | 126,470 | 0.08% | Shares |
| DEUTSCHE BANK AG\ | $294,573 | 120,234 | 0.08% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $283,690 | 115,792 | 0.07% | Shares |
| CITADEL ADVISORS LLC | $276,850 | 113,000 | 0.07% | Call option |
| CITADEL ADVISORS LLC | $275,135 | 112,300 | 0.07% | Put option |
| RAYMOND JAMES FINANCIAL INC | $223,741 | 91,323 | 0.06% | Shares |
| Squarepoint Ops LLC | $220,865 | 90,149 | 0.06% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $200,655 | 81,900 | 0.05% | Shares |
| JANE STREET GROUP, LLC | $186,935 | 76,300 | 0.05% | Call option |
| MetLife Investment Management, LLC | $186,864 | 76,271 | 0.05% | Shares |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $175,118 | 77,830 | 0.04% | Shares |
| AXQ CAPITAL, LP | $144,687 | 59,056 | 0.04% | Shares |
| Spark Investment Management LLC | $144,550 | 59,000 | 0.04% | Shares |
| CITIGROUP INC | $139,652 | 57,001 | 0.04% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $138,450 | 56,510 | 0.04% | Shares |
| JPMORGAN CHASE & CO | $123,411 | 51,208 | 0.03% | Shares |
| Verdad Advisers, LP | $113,190 | 46,200 | 0.03% | Shares |
| Quadrature Capital Ltd | $112,431 | 45,890 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $109,309 | 44,616 | 0.03% | Shares |
| Legal & General Group Plc | $107,702 | 43,960 | 0.03% | Shares |
| MORGAN STANLEY | $94,212 | 38,454 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $89,055 | 36,349 | 0.02% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $84,775 | 34,602 | 0.02% | Shares |
| State of Wyoming | $81,891 | 33,425 | 0.02% | Shares |
| HarbourVest Partners LLC | $71,094 | 29,018 | 0.02% | Shares |
| Parametrica Management Ltd | $68,208 | 27,840 | 0.02% | Shares |
| ALLIANCEBERNSTEIN L.P. | $67,325 | 29,790 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $62,629 | 25,563 | 0.02% | Shares |
| Magnus Financial Group LLC | $61,961 | 25,290 | 0.02% | Shares |
| BARCLAYS PLC | $60,514 | 24,700 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $59,782 | 24,401 | 0.02% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $58,964 | 24,067 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $55,615 | 22,700 | 0.01% | Shares |
| JANE STREET GROUP, LLC | $53,900 | 22,000 | 0.01% | Put option |
| Schonfeld Strategic Advisors LLC | $52,752 | 21,532 | 0.01% | Shares |
| Quadrant Private Wealth Management, LLC | $49,053 | 20,022 | 0.01% | Shares |
| PRUDENTIAL FINANCIAL INC | $45,558 | 18,595 | 0.01% | Shares |
| ProShare Advisors LLC | $39,536 | 16,137 | 0.01% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $34,547 | 14,101 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $30,583 | 12,483 | 0.01% | Shares |
| XPONANCE LLC | $28,834 | 11,769 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $27,403 | 11,185 | 0.01% | Shares |
| Russell Investments Group, Ltd. | $24,144 | 9,855 | 0.01% | Shares |
| FMR LLC | $22,035 | 8,994 | 0.01% | Shares |
| ROYAL BANK OF CANADA | $15,000 | 6,383 | 0.00% | Shares |
| SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ | $12,250 | 5,000 | 0.00% | Shares |
| Point72 Asia (Singapore) Pte. Ltd. | $8,895 | 17,861 | 0.00% | Shares |
| Advisors Asset Management, Inc. | $8,270 | 8,313 | 0.00% | Shares |
| Sterling Capital Management LLC | $6,086 | 2,484 | 0.00% | Shares |
| Truvestments Capital LLC | $5,709 | 2,330 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $4,158 | 1,697 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $2,984 | 1,218 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $2,163 | 883 | 0.00% | Shares |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | $1,225 | 500 | 0.00% | Shares |
| Optiver Holding B.V. | $902 | 368 | 0.00% | Shares |
| Fortitude Family Office, LLC | $720 | 294 | 0.00% | Shares |
| Point72 (DIFC) Ltd | $530 | 1,064 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $295 | 120,598 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $248 | 101,164 | 0.00% | Shares |
| Arax Advisory Partners | $243 | 99 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $86 | 35 | 0.00% | Shares |
| Virtu Financial LLC | $76 | 31,063 | 0.00% | Shares |
| HRT FINANCIAL LP | $27 | 11,267 | 0.00% | Shares |
| FNY Investment Advisers, LLC | $24 | 10,000 | 0.00% | Shares |
| Smartleaf Asset Management LLC | $2 | 1 | 0.00% | Shares |