GPCR — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| FMR LLC | $419,179,123 | 7,810,306 | 11.69% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $396,054,169 | 7,379,433 | 11.05% | Shares |
| Avoro Capital Advisors LLC | $351,836,637 | 6,555,555 | 9.81% | Shares |
| JANUS HENDERSON GROUP PLC | $258,260,143 | 5,354,981 | 7.20% | Shares |
| Deep Track Capital, LP | $254,399,664 | 4,740,072 | 7.10% | Shares |
| BVF INC/IL | $180,697,390 | 3,366,823 | 5.04% | Shares |
| MORGAN STANLEY | $150,632,372 | 2,806,640 | 4.20% | Shares |
| ORBIMED ADVISORS LLC | $118,578,498 | 2,209,400 | 3.31% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $94,070,254 | 1,752,753 | 2.62% | Shares |
| AMERICAN CENTURY COMPANIES INC | $90,282,956 | 1,682,179 | 2.52% | Shares |
| RTW INVESTMENTS, LP | $86,274,901 | 1,607,507 | 2.41% | Shares |
| Driehaus Capital Management LLC | $83,361,264 | 1,553,219 | 2.33% | Shares |
| BAKER BROS. ADVISORS LP | $76,883,831 | 1,432,529 | 2.14% | Shares |
| Casdin Capital, LLC | $63,062,250 | 1,175,000 | 1.76% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $58,285,620 | 1,086,000 | 1.63% | Shares |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $55,875,837 | 1,041,100 | 1.56% | Shares |
| Siren, L.L.C. | $46,852,139 | 872,967 | 1.31% | Shares |
| Pacific Heights Asset Management LLC | $42,936,000 | 800,000 | 1.20% | Shares |
| Rock Springs Capital Management LP | $34,365,813 | 640,317 | 0.96% | Shares |
| Aberdeen Group plc | $34,344,238 | 639,915 | 0.96% | Shares |
| FRANKLIN RESOURCES INC | $31,066,308 | 578,839 | 0.87% | Shares |
| BANK OF AMERICA CORP /DE/ | $30,238,858 | 563,422 | 0.84% | Shares |
| ALLIANCEBERNSTEIN L.P. | $29,484,326 | 611,708 | 0.82% | Shares |
| BlackRock, Inc. | $27,433,368 | 511,149 | 0.77% | Shares |
| Logos Global Management LP | $26,835,000 | 500,000 | 0.75% | Shares |
| Parkman Healthcare Partners LLC | $26,065,426 | 485,661 | 0.73% | Shares |
| Davern Capital Partners, LP | $23,939,987 | 446,059 | 0.67% | Shares |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $22,476,996 | 418,800 | 0.63% | Shares |
| UBS Group AG | $20,340,179 | 378,986 | 0.57% | Shares |
| DEUTSCHE BANK AG\ | $17,811,302 | 331,867 | 0.50% | Shares |
| NEXTBio Capital Management LP | $16,771,660 | 312,496 | 0.47% | Shares |
| Catalio Capital Management, LP | $14,842,438 | 276,550 | 0.41% | Shares |
| MARSHALL WACE, LLP | $14,361,663 | 267,592 | 0.40% | Shares |
| HSG Holding Ltd | $14,279,548 | 266,062 | 0.40% | Shares |
| SEB Asset Management AB | $13,151,433 | 245,043 | 0.37% | Shares |
| GOLDMAN SACHS GROUP INC | $13,030,539 | 242,790 | 0.36% | Shares |
| AMERIPRISE FINANCIAL INC | $12,371,685 | 230,514 | 0.35% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $11,581,986 | 215,800 | 0.32% | Shares |
| TWO SIGMA INVESTMENTS, LP | $10,957,053 | 204,156 | 0.31% | Shares |
| Eversept Partners, LP | $10,535,528 | 196,302 | 0.29% | Shares |
| Schonfeld Strategic Advisors LLC | $10,234,062 | 190,685 | 0.29% | Shares |
| Woodline Partners LP | $8,254,875 | 153,808 | 0.23% | Shares |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $8,218,000 | 153,119 | 0.23% | Shares |
| ArrowMark Colorado Holdings LLC | $8,081,575 | 150,579 | 0.23% | Shares |
| Susquehanna Portfolio Strategies, LLC | $7,994,039 | 148,948 | 0.22% | Shares |
| CenterBook Partners LP | $7,944,770 | 148,030 | 0.22% | Shares |
| Rhenman & Partners Asset Management AB | $7,787,517 | 145,100 | 0.22% | Shares |
| GOLDMAN SACHS GROUP INC | $7,782,150 | 145,000 | 0.22% | Call option |
| B Group, Inc. | $7,513,800 | 140,000 | 0.21% | Shares |
| HighVista Strategies LLC | $7,019,177 | 130,784 | 0.20% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $6,745,728 | 125,689 | 0.19% | Shares |
| Squarepoint Ops LLC | $6,739,610 | 125,575 | 0.19% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6,566,202 | 122,344 | 0.18% | Shares |
| D. E. Shaw & Co., Inc. | $6,188,151 | 115,300 | 0.17% | Shares |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $6,027,141 | 112,300 | 0.17% | Shares |
| Soleus Capital Management, L.P. | $5,742,690 | 107,000 | 0.16% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5,302,596 | 98,800 | 0.15% | Call option |
| Avidity Partners Management LP | $5,259,660 | 98,000 | 0.15% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $5,215,811 | 97,183 | 0.15% | Shares |
| Qube Research & Technologies Ltd | $5,012,939 | 93,403 | 0.14% | Shares |
| PEREGRINE CAPITAL MANAGEMENT LLC | $4,949,930 | 92,229 | 0.14% | Shares |
| PFM Health Sciences, LP | $4,913,489 | 91,550 | 0.14% | Shares |
| PLATINUM INVESTMENT MANAGEMENT LTD | $4,849,782 | 90,363 | 0.14% | Shares |
| MILLENNIUM MANAGEMENT LLC | $4,807,115 | 89,568 | 0.13% | Shares |
| ExodusPoint Capital Management, LP | $4,200,536 | 78,266 | 0.12% | Shares |
| Boxer Capital Management, LLC | $4,025,250 | 75,000 | 0.11% | Shares |
| Cormorant Asset Management, LP | $4,025,250 | 75,000 | 0.11% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4,025,250 | 75,000 | 0.11% | Shares |
| CITADEL ADVISORS LLC | $4,014,516 | 74,800 | 0.11% | Call option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3,869,607 | 72,100 | 0.11% | Put option |
| ALPS ADVISORS INC | $3,855,277 | 71,833 | 0.11% | Shares |
| TD Asset Management Inc | $3,701,191 | 68,962 | 0.10% | Shares |
| Point72 Europe (London) LLP | $3,267,516 | 116,697 | 0.09% | Shares |
| Brevan Howard Capital Management LP | $3,258,144 | 60,336 | 0.09% | Shares |
| Burkehill Global Management, LP | $3,220,200 | 60,000 | 0.09% | Shares |
| RAYMOND JAMES FINANCIAL INC | $3,185,689 | 59,357 | 0.09% | Shares |
| JANE STREET GROUP, LLC | $3,026,988 | 56,400 | 0.08% | Call option |
| CITADEL ADVISORS LLC | $2,908,914 | 54,200 | 0.08% | Put option |
| TUDOR INVESTMENT CORP ET AL | $2,879,718 | 53,656 | 0.08% | Shares |
| ANTIPODES PARTNERS Ltd | $2,751,232 | 51,262 | 0.08% | Shares |
| SCOGGIN MANAGEMENT LP | $2,683,500 | 50,000 | 0.07% | Call option |
| Buckland Partners Management Co LLC | $2,683,500 | 50,000 | 0.07% | Shares |
| SEVEN GRAND MANAGERS, LLC | $2,683,500 | 50,000 | 0.07% | Shares |
| DAFNA Capital Management LLC | $2,495,655 | 46,500 | 0.07% | Shares |
| Mariner, LLC | $2,484,116 | 46,285 | 0.07% | Shares |
| OSAIC HOLDINGS, INC. | $2,403,594 | 44,786 | 0.07% | Shares |
| STATE STREET CORP | $2,395,238 | 44,629 | 0.07% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $2,383,485 | 44,410 | 0.07% | Shares |
| BANQUE PICTET & CIE SA | $2,325,628 | 43,332 | 0.06% | Shares |
| Jump Financial, LLC | $2,289,455 | 42,658 | 0.06% | Shares |
| BANK OF MONTREAL /CAN/ | $2,284,733 | 42,570 | 0.06% | Shares |
| Cinctive Capital Management LP | $2,193,869 | 40,877 | 0.06% | Shares |
| Jefferies Financial Group Inc. | $2,180,344 | 40,625 | 0.06% | Shares |
| Jones Hill Capital LP | $2,177,231 | 40,567 | 0.06% | Shares |
| STEMPOINT CAPITAL LP | $2,049,013 | 38,178 | 0.06% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2,045,256 | 38,108 | 0.06% | Shares |
| CAPITAL FUND MANAGEMENT S.A. | $2,000,871 | 37,281 | 0.06% | Shares |
| PSquared Asset Management AG | $1,996,524 | 37,200 | 0.06% | Shares |
| FLAX POND CAPITAL, LLC | $1,932,120 | 36,000 | 0.05% | Shares |
| TrueMark Investments, LLC | $1,803,312 | 33,600 | 0.05% | Shares |
| NOMURA ASSET MANAGEMENT CO LTD | $1,759,839 | 32,790 | 0.05% | Shares |
| DCF Advisers, LLC | $1,722,807 | 32,100 | 0.05% | Shares |
| EXCHANGE TRADED CONCEPTS, LLC | $1,651,587 | 30,773 | 0.05% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $1,534,962 | 28,600 | 0.04% | Shares |
| Verition Fund Management LLC | $1,530,615 | 28,519 | 0.04% | Shares |
| Y-Intercept (Hong Kong) Ltd | $1,479,843 | 27,573 | 0.04% | Shares |
| Seven Fleet Capital Management LP | $1,441,572 | 26,800 | 0.04% | Shares |
| MML INVESTORS SERVICES, LLC | $1,374,006 | 25,601 | 0.04% | Shares |
| Birchview Capital, LP | $1,288,080 | 24,000 | 0.04% | Shares |
| NOMURA HOLDINGS INC | $1,227,594 | 22,873 | 0.03% | Shares |
| BARCLAYS PLC | $1,085,798 | 20,231 | 0.03% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $954,306 | 17,781 | 0.03% | Shares |
| ADAR1 Capital Management, LLC | $939,225 | 17,500 | 0.03% | Shares |
| STIFEL FINANCIAL CORP | $806,771 | 15,032 | 0.02% | Shares |
| LPL Financial LLC | $769,252 | 14,333 | 0.02% | Shares |
| WEXFORD CAPITAL LP | $735,762 | 13,709 | 0.02% | Shares |
| SEI INVESTMENTS CO | $734,422 | 13,684 | 0.02% | Shares |
| BRANDYWINE MANAGERS, LLC | $716,870 | 13,357 | 0.02% | Shares |
| Gladstone Institutional Advisory LLC | $712,469 | 13,275 | 0.02% | Shares |
| Fulcrum Asset Management LLP | $684,996 | 13,252 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $665,991 | 12,409 | 0.02% | Shares |
| ENVESTNET ASSET MANAGEMENT INC | $621,241 | 11,575 | 0.02% | Shares |
| Verdad Advisers, LP | $608,349 | 11,335 | 0.02% | Shares |
| DNB Asset Management AS | $578,509 | 10,779 | 0.02% | Shares |
| FOX RUN MANAGEMENT, L.L.C. | $578,348 | 10,776 | 0.02% | Shares |
| WELLS FARGO & COMPANY/MN | $558,033 | 10,398 | 0.02% | Shares |
| HighTower Advisors, LLC | $538,253 | 10,029 | 0.02% | Shares |
| Quinn Opportunity Partners LLC | $536,700 | 10,000 | 0.01% | Shares |
| SmartHarvest Portfolios, LLC | $532,836 | 9,928 | 0.01% | Shares |
| CITIGROUP INC | $519,526 | 9,680 | 0.01% | Shares |
| Gilbert & Cook, Inc. | $491,993 | 9,167 | 0.01% | Shares |
| IMC-Chicago, LLC | $462,528 | 8,618 | 0.01% | Shares |
| Cubist Systematic Strategies, LLC | $456,736 | 16,312 | 0.01% | Shares |
| JANE STREET GROUP, LLC | $450,828 | 8,400 | 0.01% | Put option |
| SIMPLEX TRADING, LLC | $422,436 | 7,871 | 0.01% | Shares |
| Clearstead Advisors, LLC | $420,021 | 7,826 | 0.01% | Shares |
| Quadcap Wealth Management, LLC | $409,769 | 7,635 | 0.01% | Shares |
| Virtus Investment Advisers, LLC | $409,073 | 7,622 | 0.01% | Shares |
| Allianz Asset Management GmbH | $407,892 | 7,600 | 0.01% | Shares |
| MISSION WEALTH MANAGEMENT, LP | $406,980 | 7,583 | 0.01% | Shares |
| Vestmark Advisory Solutions, Inc. | $404,350 | 7,534 | 0.01% | Shares |
| Parallel Advisors, LLC | $394,582 | 7,352 | 0.01% | Shares |
| Cetera Investment Advisers | $356,261 | 6,638 | 0.01% | Shares |
| EntryPoint Capital, LLC | $329,319 | 6,136 | 0.01% | Shares |
| Good Life Advisors, LLC | $311,100 | 15,000 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $274,093 | 5,107 | 0.01% | Shares |
| NORTHERN TRUST CORP | $272,644 | 5,080 | 0.01% | Shares |
| Concurrent Investment Advisors, LLC | $268,350 | 5,000 | 0.01% | Shares |
| Bellevue Group AG | $255,577 | 4,762 | 0.01% | Shares |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $249,297 | 4,645 | 0.01% | Shares |
| Independent Advisor Alliance | $243,823 | 4,543 | 0.01% | Shares |
| SECTORAL ASSET MANAGEMENT INC | $232,123 | 4,325 | 0.01% | Shares |
| PEAK6 LLC | $222,999 | 4,155 | 0.01% | Shares |
| Walleye Trading LLC | $220,745 | 4,113 | 0.01% | Shares |
| Prospera Financial Services Inc | $220,042 | 4,100 | 0.01% | Shares |
| E. Ohman J:or Asset Management AB | $217,768 | 4,518 | 0.01% | Shares |
| GABELLI FUNDS LLC | $217,364 | 4,050 | 0.01% | Shares |
| TUDOR INVESTMENT CORP ET AL | $214,680 | 4,000 | 0.01% | Call option |
| Invesco Ltd. | $212,050 | 3,951 | 0.01% | Shares |
| JPMORGAN CHASE & CO | $205,933 | 3,984 | 0.01% | Shares |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | $187,845 | 3,500 | 0.01% | Shares |
| State of Wyoming | $166,431 | 3,101 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $149,310 | 2,782 | 0.00% | Shares |
| ASSETMARK, INC | $146,304 | 2,726 | 0.00% | Shares |
| NATIXIS | $135,095 | 2,482 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $134,926 | 2,514 | 0.00% | Shares |
| Sterling Capital Management LLC | $109,755 | 2,045 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $88,878 | 1,656 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $88,609 | 1,651 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $80,490 | 1,500 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $75,138 | 1,400 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $48,142 | 897 | 0.00% | Shares |
| IFP Advisors, Inc | $46,049 | 858 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $45,380 | 845,532 | 0.00% | Shares |
| GAMMA Investing LLC | $44,868 | 836 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $30,000 | 550 | 0.00% | Shares |
| WOLFF WIESE MAGANA LLC | $21,468 | 400 | 0.00% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $20,663 | 385 | 0.00% | Shares |
| North Star Investment Management Corp. | $17,711 | 330 | 0.00% | Shares |
| Quarry LP | $13,149 | 245 | 0.00% | Shares |
| Godfrey Financial Associates, Inc. | $13,149 | 245 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $8,699 | 175 | 0.00% | Shares |
| Dynamic Wealth Strategies, LLC | $8,051 | 150 | 0.00% | Shares |
| CWM, LLC | $6,025 | 125 | 0.00% | Shares |
| Key Financial Inc | $5,367 | 100 | 0.00% | Shares |
| SHP Wealth Management | $5,367 | 100 | 0.00% | Shares |
| SIGNATUREFD, LLC | $5,367 | 100 | 0.00% | Shares |
| HUNTINGTON NATIONAL BANK | $4,240 | 79 | 0.00% | Shares |
| Rakuten Securities, Inc. | $3,220 | 60 | 0.00% | Shares |
| Arax Advisory Partners | $1,825 | 34 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $1,538 | 28,665 | 0.00% | Shares |
| Transamerica Financial Advisors, LLC | $1,180 | 22 | 0.00% | Shares |
| Ares Financial Consulting, LLC | $1,073 | 20 | 0.00% | Shares |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $928 | 17,297 | 0.00% | Shares |
| Smartleaf Asset Management LLC | $879 | 17 | 0.00% | Shares |
| Janney Capital Management LLC | $592 | 8,513 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $537 | 10 | 0.00% | Shares |
| Cullen/Frost Bankers, Inc. | $429 | 8 | 0.00% | Shares |
| Larson Financial Group LLC | $322 | 6 | 0.00% | Shares |
| Janney Montgomery Scott LLC | $288 | 5,364 | 0.00% | Shares |
| SG Americas Securities, LLC | $130 | 2,427 | 0.00% | Shares |
| Point72 Asia (Singapore) Pte. Ltd. | $28 | 1 | 0.00% | Shares |
| Capital Analysts, LLC | $1 | 18 | 0.00% | Shares |
| BESSEMER GROUP INC | $1 | 22 | 0.00% | Shares |