LXEO Lexeo Therapeutics, Inc. - Common Stock
$4.93
Price · Aug 18, 2026
Fundamentals as of Aug 12, 2026
52W Range
$4–$11
13% of range
Analyst Rating
STRONG BUY
16 analysts
Price Target
$20
+312% upside
P/E (TTM)
-2.7
ROE
-51.9%
Net Profit Margin
—
LXEO Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$4.93
Market Cap
$360M
P/E (TTM)
-2.7
EPS (TTM)
$-1.86
Revenue (TTM)
—
Div Yield
—
ROE
-51.9%
Debt/Equity
—
52W Range
$4 – $11
LXEO Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
Configure
10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
2022-12-31
→
2022-12-31
EPS
$-1.86
2022-12-31
→
2025-12-31
Free Cash Flow
$-99M
2023-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
LXEO
Peer Median
P/E (TTM)
-2.7
17.4
P/B
1.5
4.8
Price / FCF
-3.6
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
LXEO
Peer Median
ROA
-48.1%
-41.1%
ROE
-51.9%
-52.6%
ROIC
-44.3%
—
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
LXEO
Peer Median
Current Ratio
11.2
7.7
Quick Ratio
3.7
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
LXEO
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
LXEO
Peer Median
LXEO Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
16 analysts
- Strong Buy 8 50.0%
- Buy 7 43.8%
- Hold 1 6.2%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
10 analysts · 2026-08-18
Median
$20.00
← Below all targets
$4.93
Low
$9.00
High
$30.00
Median target
$20.00
+305.7%
Mean target
$20.30
+311.8%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.04%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.25 | $-0.32 | 0.07% |
| Dec. 31, 2025 | $-0.27 | $-0.32 | 0.05% |
| Sept. 30, 2025 | $-0.33 | $-0.53 | 0.20% |
| June 30, 2025 | $-0.60 | $-0.69 | 0.09% |
| March 31, 2025 | $-0.99 | $-0.80 | -0.19% |
| Dec. 31, 2024 | $-0.78 | $-0.82 | 0.04% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| LXEO | $725M | -5.3 | — | — | -51.9% | — |
| BNTC | $307M | -11.1 | — | — | -43.8% | — |
| EDIT | $201M | -1.1 | 25.4% | -395.0% | -688.8% | — |
| CMPX | $958M | — | — | — | -45.9% | — |
| PROK | — | — | 1075.0% | -7725.2% | 6.9% | — |
| FENC | $263M | -22.6 | -6.1% | -21.8% | -69.6% | — |
| CAPR | $1.66B | -12.8 | -11.6% | — | -51.1% | — |
| FHTX | $306M | -4.6 | 36.8% | -240.3% | 80.2% | — |
| UPB | $1.47B | -10.2 | 20.4% | -5026.0% | -38.3% | — |
| PALI | $375M | -7.8 | — | — | -25.4% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 16
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue | · | · | · | $654.0K | |
| R&D Expense | $64M | $74M | $53M | $49M | |
| SG&A Expense | $45M | $32M | $15M | $12M | |
| Operating Expenses | $109M | $106M | $69M | $61M | |
| Operating Income | $-109M | $-106M | $-69M | $-61M | |
| Interest Expense | · | · | $205.0K | $91.0K | |
| Interest Income | $6M | $8M | $3M | $1M | |
| Other Non-op | $-18.0K | $-9.0K | $-13.0K | $-2.0K | |
| Pretax Income | $-100M | $-98M | $-66M | $-59M | |
| Income Tax | $0 | $0 | · | · | |
| Net Income | $-100M | $-98M | $-66M | $-59M | |
| EPS (Basic) | $-1.86 | $-3.09 | $-12.40 | $-36.36 | |
| EPS (Diluted) | $-1.86 | $-3.09 | $-12.40 | $-36.36 | |
| Shares (Basic) | 53,645,323 | 31,787,491 | 5,354,368 | 1,630,348 | |
| Shares (Diluted) | 53,645,323 | 31,787,491 | 5,354,368 | 1,630,348 | |
| EBITDA | $-109M | $-106M | $-69M | · |
Balance Sheet 20
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $63M | $35M | $121M | $77M | |
| Short-term Investments | · | $87M | · | · | |
| Prepaid Expense | $7M | $5M | $3M | $2M | |
| Other Current Assets | · | · | $3.0K | $371.0K | |
| Current Assets | $188M | $126M | $124M | $80M | |
| PP&E (Net) | $1M | $1M | $1M | $998.0K | |
| PP&E (Gross) | $2M | $2M | $1M | $1M | |
| Accum. Depreciation | $741.0K | $474.0K | $381.0K | $133.0K | |
| Total Assets | $269M | $147M | $140M | $97M | |
| Accounts Payable | $5M | $6M | $4M | $3M | |
| Current Liabilities | $17M | $23M | $17M | $14M | |
| Capital Leases | $5M | $6M | $8M | $9M | |
| Total Liabilities | $22M | $30M | $26M | $25M | |
| Common Stock | $7.0K | $3.0K | $3.0K | $0 | |
| Retained Earnings | $-380M | $-280M | $-182M | $-115M | |
| Treasury Stock | $17.0K | $17.0K | · | · | |
| AOCI | $188.0K | $-103.0K | · | · | |
| Stockholders' Equity | $247M | $117M | $114M | $-113M | |
| Liabilities + Equity | $269M | $147M | $140M | $97M | |
| Shares Outstanding | 73,001,350 | 33,071,261 | 26,646,378 | 1,607,185 |
Cash Flow 11
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| D&A | $268.0K | $304.0K | $271.0K | $120.0K | |
| Stock-based Comp | $12M | $12M | $3M | $2M | |
| Operating Cash Flow | $-99M | $-81M | $-59M | $-55M | |
| CapEx | $397.0K | $481.0K | $115.0K | $672.0K | |
| Investing Cash Flow | $-90M | $-94M | $-165.0K | $-901.0K | |
| Stock Issued | $270.0K | · | · | · | |
| Net Stock Activity | $270.0K | · | · | · | |
| Financing Cash Flow | $217M | $89M | $104M | $189.0K | |
| Net Change in Cash | $28M | $-86M | $44M | $-55M | |
| Taxes Paid | $551.0K | $133.0K | · | · | |
| Free Cash Flow | $-99M | $-82M | $-60M | · |
Profitability 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| ROA | -48.1% | -68.6% | -56.1% | · | |
| ROE | -51.9% | -76.8% | 269.5% | · | |
| ROIC | -44.3% | · | · | · |
Liquidity & Solvency 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 11.2 | 5.5 | 7.2 | · | |
| Quick Ratio | 3.7 | 5.3 | 7.0 | · | |
| Interest Coverage | · | · | -334.2 | · |
Valuation (TTM) 8
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Net Income TTM | $-100M | $-98M | $-66M | · | |
| Market Cap | $725M | $218M | $358M | · | |
| P/E | -5.3 | -2.1 | -1.1 | · | |
| P/B | 2.9 | 1.9 | 3.1 | · | |
| P / Tangible Book | 2.9 | 1.9 | 3.1 | · | |
| P / Cash Flow | -7.4 | -2.7 | -6.0 | · | |
| P / FCF | -7.3 | -2.7 | -6.0 | · | |
| Earnings Yield | -18.7% | -47.0% | -92.4% | · |
Income Statement 15
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $0 | |
| R&D Expense | $19M | $16M | $16M | $16M | $15M | $17M | $18M | $23M | $17M | $16M | $8M | $17M | $11M | $16M | $11M | |
| SG&A Expense | $9M | $7M | $7M | $6M | $16M | $17M | $9M | $8M | $7M | $8M | $7M | $3M | $3M | $3M | $4M | |
| Operating Expenses | $28M | $22M | $23M | $22M | $31M | $34M | $27M | $32M | $24M | $23M | $15M | $20M | $14M | $19M | $15M | |
| Operating Income | $-28M | $-22M | $-23M | $-22M | $-31M | $-34M | $-27M | $-32M | $-24M | $-23M | $-15M | $-20M | $-14M | $-19M | $-15M | |
| Interest Expense | · | · | · | · | · | · | · | · | $35.0K | $37.0K | · | $52.0K | $53.0K | $50.0K | $54.0K | |
| Interest Income | $2M | $2M | $2M | $1M | $1M | $1M | $1M | $2M | $2M | $2M | $1M | $488.0K | $590.0K | $687.0K | $676.0K | |
| Other Non-op | $-6.0K | $-1.0K | $9.0K | $-9.0K | $-14.0K | $-4.0K | $0 | $-3.0K | $-1.0K | $-5.0K | $-7.0K | $1.0K | $-3.0K | $-4.0K | · | |
| Pretax Income | $-26M | $-20M | $-21M | $-20M | $-26M | $-33M | $-26M | $-29M | $-21M | $-22M | $-14M | $-20M | $-13M | $-19M | $-15M | |
| Net Income | $-26M | $-20M | $-21M | $-20M | $-26M | $-33M | $-26M | $-29M | $-21M | $-22M | $-14M | $-20M | $-13M | $-19M | $-15M | |
| EPS (Basic) | $-0.30 | $-0.25 | $0.06 | $-0.33 | $-0.60 | $-0.99 | $-0.79 | $-0.89 | $-0.64 | $-0.77 | $19.84 | $-12.36 | $-8.30 | $-11.58 | $-8.86 | |
| EPS (Diluted) | $-0.30 | $-0.25 | $0.06 | $-0.33 | $-0.60 | $-0.99 | $-0.79 | $-0.89 | $-0.64 | $-0.77 | $19.84 | $-12.36 | $-8.30 | $-11.58 | $-8.86 | |
| Shares (Basic) | 85,626,751 | 81,183,812 | -84,023,163 | 60,980,867 | 43,573,628 | 33,113,991 | -62,257,446 | 33,063,153 | 33,001,946 | 27,979,838 | 497,294 | 1,626,734 | 1,619,547 | 1,610,793 | 4,737 | |
| Shares (Diluted) | 85,626,751 | 81,183,812 | -84,023,163 | 60,980,867 | 43,573,628 | 33,113,991 | -62,257,446 | 33,063,153 | 33,001,946 | 27,979,838 | 497,294 | 1,626,734 | 1,619,547 | 1,610,793 | 4,737 | |
| EBITDA | $-28M | $-22M | · | $-22M | $-31M | · | · | $-32M | $-24M | $-23M | · | $-20M | · | · | · |
Balance Sheet 20
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $93M | $72M | $63M | $41M | $35M | $29M | $35M | $157M | $175M | $195M | $121M | $35M | · | · | $77M | |
| Short-term Investments | · | · | · | · | · | $71M | · | · | · | · | · | · | · | · | · | |
| Prepaid Expense | $6M | $8M | $7M | $5M | $7M | $5M | $5M | $2M | $2M | $3M | $3M | $1M | · | · | $2M | |
| Other Current Assets | · | · | · | · | · | · | · | · | · | · | · | $2M | · | · | $371.0K | |
| Current Assets | $218M | $201M | $188M | $128M | $140M | $105M | $126M | $159M | $177M | $198M | $124M | $39M | · | · | $80M | |
| PP&E (Net) | $1M | $1M | $1M | $1M | $1M | $1M | $1M | $1M | $1M | $1M | $1M | $980.0K | · | · | $998.0K | |
| PP&E (Gross) | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $1M | $1M | $1M | · | · | $1M | |
| Accum. Depreciation | $887.0K | $814.0K | $741.0K | $668.0K | $596.0K | $534.0K | $474.0K | $610.0K | $527.0K | $450.0K | $381.0K | $316.0K | · | · | $133.0K | |
| Total Assets | $255M | $250M | $269M | $144M | $176M | $126M | $147M | $174M | $192M | $213M | $140M | $55M | · | · | $97M | |
| Accounts Payable | $4M | $3M | $5M | $5M | $20M | $12M | $6M | $8M | $6M | $4M | $4M | $3M | · | · | $3M | |
| Current Liabilities | $16M | $14M | $17M | $17M | $32M | $31M | $23M | $27M | $19M | $22M | $17M | $23M | · | · | $14M | |
| Capital Leases | $4M | $4M | $5M | $5M | $6M | $6M | $6M | $7M | $7M | $7M | $8M | $8M | · | · | $9M | |
| Total Liabilities | $20M | $19M | $22M | $23M | $38M | $38M | $30M | $35M | $27M | $30M | $26M | $32M | · | · | $25M | |
| Common Stock | $8.0K | $7.0K | $7.0K | $5.0K | $5.0K | $3.0K | $3.0K | $3.0K | $3.0K | $3.0K | $3.0K | $0 | · | · | $0 | |
| Retained Earnings | $-426M | $-400M | $-380M | $-359M | $-339M | $-313M | $-280M | $-254M | $-225M | $-204M | $-182M | $-168M | · | · | $-115M | |
| Treasury Stock | $17.0K | $17.0K | $17.0K | $17.0K | $17.0K | $17.0K | $17.0K | $13.0K | $13.0K | · | · | · | · | · | · | |
| AOCI | $-298.0K | $-142.0K | $188.0K | $89.0K | $-13.0K | $-54.0K | $-103.0K | · | · | · | · | · | · | · | · | |
| Stockholders' Equity | $235M | $231M | $247M | $121M | $138M | $88M | $117M | $139M | $165M | $183M | $114M | $-163M | · | · | $-113M | |
| Liabilities + Equity | $255M | $250M | $269M | $144M | $176M | $126M | $147M | $174M | $192M | $213M | $140M | $55M | · | · | $97M | |
| Shares Outstanding | 78,622,604 | 74,086,737 | 73,001,350 | 54,934,275 | 53,998,492 | 33,191,865 | 33,071,261 | 33,058,447 | 33,039,911 | 32,928,141 | 26,646,378 | 1,633,206 | · | · | 1,607,185 |
Cash Flow 10
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $74.0K | $73.0K | $73.0K | $73.0K | $62.0K | $60.0K | $75.0K | $83.0K | $77.0K | $69.0K | $77.0K | $78.0K | $59.0K | $57.0K | $58.0K | |
| Stock-based Comp | $6M | $3M | $3M | $3M | $3M | $4M | $4M | $4M | $3M | $2M | $804.0K | $875.0K | $969.0K | $397.0K | $521.0K | |
| Operating Cash Flow | $-18M | $-21M | $-20M | $-30M | $-27M | $-22M | $-28M | $-18M | $-20M | $-15M | $-14M | $-14M | $-13M | $-18M | $-17M | |
| CapEx | $7.0K | $35.0K | $0 | $289.0K | · | · | $0 | $83.0K | $213.0K | $185.0K | $73.0K | $3.0K | · | · | $25.0K | |
| Investing Cash Flow | $14M | $27M | $-102M | $35M | $-39M | $16M | $-94M | $-83.0K | $-218.0K | $-193.0K | $-73.0K | $-53.0K | · | · | $-107.0K | |
| Stock Issued | $25M | $143.0K | $-1.0K | $101.0K | $0 | $170.0K | · | · | · | · | · | · | · | · | · | |
| Net Stock Activity | · | $143.0K | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $24M | $2M | $144M | $52.0K | $73M | $11.0K | $-97.0K | $-72.0K | $291.0K | $89M | $100M | $4M | $-94.0K | $-98.0K | $-81.0K | |
| Net Change in Cash | $21M | $9M | $22M | $6M | $7M | $-6M | $-122M | $-18M | $-20M | $74M | $86M | $-10M | $-13M | $-18M | $-17M | |
| Free Cash Flow | · | $-21M | · | · | · | · | · | · | · | $-15M | · | · | · | · | · |
Profitability 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -12.0% | -10.7% | · | -12.8% | -14.2% | · | · | -25.8% | -22.1% | -20.3% | · | -73.5% | · | · | · | |
| ROE | -13.9% | -12.6% | · | -15.6% | -17.2% | · | · | 251.2% | -25.8% | -23.7% | · | 24.7% | · | · | · |
Liquidity & Solvency 3
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 13.9 | 14.2 | · | 7.4 | 4.4 | · | · | 5.9 | 9.4 | 9.2 | · | 1.7 | · | · | · | |
| Quick Ratio | 5.9 | 5.1 | · | 2.4 | 1.1 | · | · | 5.9 | 9.3 | 9.0 | · | 1.5 | · | · | · | |
| Interest Coverage | · | · | · | · | · | · | · | · | -672.9 | -629.5 | · | -389.9 | · | · | · |
Valuation (TTM) 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-92M | $-99M | · | $-109M | $-109M | $-105M | · | $-93M | $-76M | $-74M | · | $-69M | · | · | · | |
| Market Cap | $366M | $425M | · | $365M | $217M | · | · | $299M | $530M | $516M | · | · | · | · | · | |
| P/E | -3.1 | -2.6 | · | -2.4 | -1.3 | -1.1 | · | -0.6 | -0.7 | -0.5 | · | · | · | · | · | |
| P/B | 1.6 | 1.8 | · | 3.0 | 1.6 | · | · | 2.1 | 3.2 | 2.8 | · | · | · | · | · | |
| P / Tangible Book | 1.6 | 1.8 | · | 3.0 | 1.6 | 1.3 | · | 2.1 | 3.2 | 2.8 | · | · | · | · | · | |
| P / Cash Flow | · | -20.1 | · | · | · | · | · | · | · | -34.7 | · | · | · | · | · | |
| P / FCF | · | -20.1 | · | · | · | · | · | · | · | -34.3 | · | · | · | · | · | |
| Earnings Yield | -31.8% | -37.8% | · | -42.3% | -77.6% | -94.8% | · | -162.2% | -137.6% | -210.5% | · | · | · | · | · |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Revenue | — | — | — | $654.0K |
| Net Income | $-100M | $-98M | $-66M | $-59M |
| Diluted EPS | $-1.86 | $-3.09 | $-12.40 | $-36.36 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Current Ratio | 11.2 | 5.5 | 7.2 | — |
| Quick Ratio | 3.7 | 5.3 | 7.0 | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Free Cash Flow | $-99M | $-82M | $-60M | — |
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Institutional owners (13F) 151 filers · $350.8M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 35 (+16 vs prior Q) | 19 (-5 vs prior Q) | 50 (-1 vs prior Q) | 40 (+3 vs prior Q) | +13.0M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| MONTANOVA CAPITAL, LLC | $29,718,451 | 6,384,200 | 8.47% | Shares |
| Affinity Asset Advisors, LLC | $27,034,429 | 5,807,611 | 7.71% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $23,275,000 | 5,000,000 | 6.64% | Shares |
| Frazier Life Sciences Management, L.P. | $22,459,095 | 4,824,725 | 6.40% | Shares |
| STATE STREET CORP | $20,271,394 | 4,354,757 | 5.78% | Shares |
| Vestal Point Capital, LP | $20,109,600 | 4,320,000 | 5.73% | Shares |
| Paradigm Biocapital Advisors LP | $19,436,403 | 4,175,382 | 5.54% | Shares |
| ORBIMED ADVISORS LLC | $18,377,242 | 3,947,850 | 5.24% | Shares |
| CITADEL ADVISORS LLC | $17,167,486 | 3,687,967 | 4.89% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $14,551,032 | 3,125,893 | 4.15% | Shares |
| MILLENNIUM MANAGEMENT LLC | $13,190,510 | 2,833,622 | 3.76% | Shares |
| Woodline Partners LP | $11,639,976 | 2,500,532 | 3.32% | Shares |
| Balyasny Asset Management L.P. | $11,231,314 | 2,412,742 | 3.20% | Shares |
| 683 Capital Management, LLC | $8,728,124 | 1,875,000 | 2.49% | Shares |
| GOLDMAN SACHS GROUP INC | $8,094,123 | 1,738,802 | 2.31% | Shares |
| ADAR1 Capital Management, LLC | $7,289,497 | 1,565,950 | 2.08% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $7,030,374 | 1,509,898 | 2.00% | Shares |
| Avoro Capital Advisors LLC | $6,932,175 | 1,489,189 | 1.98% | Shares |
| Qube Research & Technologies Ltd | $6,406,313 | 1,376,222 | 1.83% | Shares |
| Nantahala Capital Management, LLC | $6,051,500 | 1,300,000 | 1.73% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $5,599,365 | 1,202,871 | 1.60% | Shares |
| Spruce Street Capital LP | $4,322,600 | 928,593 | 1.23% | Shares |
| Blackstone Inc. | $4,217,109 | 904,959 | 1.20% | Shares |
| Aberdeen Group plc | $3,142,553 | 675,092 | 0.90% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2,857,360 | 613,826 | 0.81% | Shares |
| Ikarian Capital, LLC | $2,388,066 | 513,011 | 0.68% | Shares |
| BANK OF AMERICA CORP /DE/ | $2,076,083 | 445,990 | 0.59% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $2,004,890 | 430,696 | 0.57% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $1,807,993 | 388,398 | 0.52% | Shares |
| DAFNA Capital Management LLC | $1,755,210 | 377,059 | 0.50% | Shares |
| UBS Group AG | $1,646,785 | 353,767 | 0.47% | Shares |
| Trexquant Investment LP | $1,465,818 | 314,891 | 0.42% | Shares |
| Squarepoint Ops LLC | $1,372,173 | 294,774 | 0.39% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $1,165,449 | 250,365 | 0.33% | Shares |
| TWO SIGMA ADVISERS, LP | $807,309 | 81,300 | 0.23% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $803,495 | 172,609 | 0.23% | Shares |
| Susquehanna Portfolio Strategies, LLC | $749,744 | 161,062 | 0.21% | Shares |
| Privium Fund Management B.V. | $722,300 | 155,000 | 0.21% | Shares |
| XTX Topco Ltd | $677,563 | 145,556 | 0.19% | Shares |
| FMR LLC | $657,035 | 141,146 | 0.19% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $634,835 | 136,377 | 0.18% | Shares |
| Burkehill Global Management, LP | $581,875 | 125,000 | 0.17% | Shares |
| MORGAN STANLEY | $546,800 | 117,465 | 0.16% | Shares |
| Palumbo Wealth Management LLC | $534,129 | 114,743 | 0.15% | Shares |
| Fisher Asset Management, LLC | $532,168 | 114,322 | 0.15% | Shares |
| EntryPoint Capital, LLC | $482,481 | 103,648 | 0.14% | Shares |
| ALLIANCEBERNSTEIN L.P. | $446,916 | 77,860 | 0.13% | Shares |
| CITIGROUP INC | $417,330 | 89,652 | 0.12% | Shares |
| VANGUARD GROUP INC | $375,265 | 37,791 | 0.11% | Shares |
| RHUMBLINE ADVISERS | $371,505 | 79,809 | 0.11% | Shares |
| Virtus Investment Advisers, LLC | $348,538 | 74,874 | 0.10% | Shares |
| Walleye Capital LLC | $343,856 | 73,868 | 0.10% | Shares |
| Rafferty Asset Management, LLC | $314,375 | 67,535 | 0.09% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $307,677 | 66,096 | 0.09% | Shares |
| Bank of New York Mellon Corp | $303,059 | 65,104 | 0.09% | Shares |
| WELLS FARGO & COMPANY/MN | $276,344 | 59,365 | 0.08% | Shares |
| JANE STREET GROUP, LLC | $241,129 | 51,800 | 0.07% | Put option |
| Mitsubishi UFJ Asset Management Co., Ltd. | $232,694 | 49,988 | 0.07% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $224,948 | 48,324 | 0.06% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $224,259 | 48,176 | 0.06% | Shares |
| MetLife Investment Management, LLC | $184,096 | 39,548 | 0.05% | Shares |
| PROFUND ADVISORS LLC | $159,746 | 34,317 | 0.05% | Shares |
| Dynamic Technology Lab Private Ltd | $152,000 | 32,651 | 0.04% | Shares |
| Verdad Advisers, LP | $142,401 | 30,591 | 0.04% | Shares |
| ExodusPoint Capital Management, LP | $129,781 | 27,880 | 0.04% | Shares |
| BlackRock, Inc. | $124,284 | 26,699 | 0.04% | Shares |
| Invesco Ltd. | $122,515 | 26,319 | 0.03% | Shares |
| Police & Firemen's Retirement System of New Jersey | $118,865 | 25,535 | 0.03% | Shares |
| AlphaQuest LLC | $116,439 | 11,726 | 0.03% | Shares |
| Quantinno Capital Management LP | $113,084 | 24,293 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $108,857 | 23,385 | 0.03% | Shares |
| CWM, LLC | $105,140 | 18,317 | 0.03% | Shares |
| PRELUDE CAPITAL MANAGEMENT, LLC | $104,738 | 22,500 | 0.03% | Shares |
| Soltis Investment Advisors LLC | $93,174 | 20,016 | 0.03% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $92,574 | 19,887 | 0.03% | Shares |
| D. E. Shaw & Co., Inc. | $92,476 | 19,866 | 0.03% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $92,192 | 19,805 | 0.03% | Shares |
| Vanguard Personalized Indexing Management, LLC | $90,614 | 19,466 | 0.03% | Shares |
| AMERICAN CENTURY COMPANIES INC | $87,770 | 18,855 | 0.03% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $86,118 | 18,500 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $82,938 | 17,817 | 0.02% | Shares |
| CAXTON CORP | $78,959 | 16,962 | 0.02% | Shares |
| Jain Global LLC | $77,203 | 16,585 | 0.02% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $76,424 | 16,400 | 0.02% | Call option |
| JANUS HENDERSON GROUP PLC | $74,001 | 12,926 | 0.02% | Shares |
| Spark Investment Management LLC | $69,825 | 15,000 | 0.02% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $66,241 | 14,230 | 0.02% | Shares |
| Cerity Partners LLC | $64,756 | 13,911 | 0.02% | Shares |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $61,431 | 12,745 | 0.02% | Shares |
| DEUTSCHE BANK AG\ | $61,176 | 13,128 | 0.02% | Shares |
| BARCLAYS PLC | $59,236 | 12,725 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $58,174 | 12,497 | 0.02% | Shares |
| ProShare Advisors LLC | $55,175 | 11,853 | 0.02% | Shares |
| PRUDENTIAL FINANCIAL INC | $53,928 | 11,585 | 0.02% | Shares |
| COMMONWEALTH EQUITY SERVICES, LLC | $51,780 | 11,123 | 0.01% | Shares |
| NORTHERN TRUST CORP | $51,773 | 11,122 | 0.01% | Shares |
| Tyche Wealth Partners LLC | $46,550 | 10,000 | 0.01% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $37,734 | 7,845 | 0.01% | Shares |
| Legal & General Group Plc | $32,036 | 6,882 | 0.01% | Shares |
| Nuveen Asset Management, LLC | $31,683 | 4,815 | 0.01% | Shares |
Company insiders 15 insiders · 7 officers · 8 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Richard Nolan Townsend | Chief Executive Officer | July 1, 2026 S | 377,817 | 0 | 1 | $-116,243 |
| Louis Edward Tamayo | Chief Financial Officer | July 1, 2026 S | 97,024 | 0 | 1 | $-20,838 |
| Jose Manuel Otero | Chief Operating Officer | July 1, 2026 S | 137,482 | 0 | 1 | $-20,904 |
| Narinder Pal Bhalla | Chief Medical Officer | July 1, 2026 S | 82,194 | 0 | 1 | $-98,593 |
| Eric Adler | Chief Medical Officer | Feb. 2, 2024 A | 26,875 | 0 | 0 | $0 |
| Jenny Robertson | Chief Legal and Admin Officer | Jan. 5, 2024 A | 23,750 | 0 | 0 | $0 |
| Paul Mccormac | Chief Technical Officer | Nov. 7, 2023 C | 17,349 | 0 | 0 | $0 |
| Brenda Cooperstone | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| Tolga Tanguler | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| Timothy Van Hauwermeiren | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| Mette Kirstine Agger | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| Steven Altschuler | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| Reinaldo M Diaz | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| CHOLMONDELEY PAULA H | Director | June 25, 2026 A | — | 0 | 0 | $0 |
| Lundbeckfond Invest A/S | 10% owner | Nov. 7, 2023 C | 1,835,959 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
ETF ownership Held by 31 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| BBC · ETFis Series Trust I | 0.43% | 28,249 NS | April 30, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.12% | 108,595 NS | April 30, 2026 | N-PORT |
| IWC · iShares Trust | 0.07% | 241,290 SH | Aug. 8, 2026 | Daily |
| VFMO · VANGUARD WELLINGTON FUND | 0.03% | 139,450 SH | Aug. 8, 2026 | Daily |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.03% | 4,231 SH | Aug. 8, 2026 | Daily |
| IBB · iShares Trust | 0.02% | 449,613 SH | Aug. 8, 2026 | Daily |
| IWN · iShares Trust | 0.02% | 658,735 SH | Aug. 8, 2026 | Daily |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0.02% | 61,750 SH | Aug. 8, 2026 | Daily |
| BIB · ProShares Trust | 0.02% | 2,697 NS | May 31, 2026 | N-PORT |
| RSSL · Global X Funds | 0.01% | 27,676 NS | April 30, 2026 | N-PORT |
| IWM · iShares Trust | 0.01% | 1,808,608 SH | Aug. 8, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.01% | 407,613 SH | Aug. 8, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.01% | 245,482 NS | April 30, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.01% | 3,114 NS | May 31, 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.01% | 36,710 SH | Aug. 8, 2026 | Daily |
| UWM · ProShares Trust | 0.01% | 2,434 NS | May 31, 2026 | N-PORT |
| URTY · ProShares Trust | 0.00% | 2,460 NS | May 31, 2026 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.00% | 18,677 NS | May 31, 2026 | N-PORT |
| DXUV · Dimensional ETF Trust | 0.00% | 1,683 NS | April 30, 2026 | N-PORT |
| HDG · ProShares Trust | 0.00% | 62 NS | May 31, 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 2,041 NS | May 31, 2026 | N-PORT |
| DFAC · Dimensional ETF Trust | 0.00% | 110,788 NS | April 30, 2026 | N-PORT |
| DFSU · Dimensional ETF Trust | 0.00% | 5,030 NS | April 30, 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 5,083 NS | April 30, 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0.00% | 18,508 NS | April 30, 2026 | N-PORT |
| ITOT · iShares Trust | 0.00% | 91,150 SH | Aug. 8, 2026 | Daily |
| IWV · iShares Trust | 0.00% | 19,305 SH | Aug. 8, 2026 | Daily |
| DFAU · Dimensional ETF Trust | 0.00% | 2,700 NS | April 30, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.00% | 715,087 SH | Aug. 8, 2026 | Daily |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 2,335,144 SH | Aug. 8, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 5,013 SH | Aug. 8, 2026 | Daily |