APGE Apogee Therapeutics, Inc. - Common Stock
$134.78
Price · Aug 19, 2026
Fundamentals as of Aug 10, 2026
52W Range
$35–$135
100% of range
Analyst Rating
HOLD
21 analysts
Price Target
$135
+0% upside
P/E (TTM)
-31.9
ROE
—
Net Profit Margin
—
APGE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$134.78
Market Cap
$9.22B
P/E (TTM)
-31.9
EPS (TTM)
$-4.22
Revenue (TTM)
—
Div Yield
—
ROE
—
Debt/Equity
—
52W Range
$35 – $135
APGE Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
Configure
10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-4.22
2022-12-31
→
2025-12-31
Free Cash Flow
$-233M
2023-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
APGE
Peer Median
P/E (TTM)
-31.9
28.5
Price / FCF
-39.6
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
APGE
Peer Median
ROA
-30.3%
-28.4%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
APGE
Peer Median
Current Ratio
26.6
5.0
Quick Ratio
26.2
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
APGE
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
APGE
Peer Median
APGE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
HOLD
21 analysts
- Strong Buy 3 14.3%
- Buy 4 19.0%
- Hold 14 66.7%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
11 analysts · 2026-08-14
Median
$135.00
Now
$134.78
Low
$133.00
High
$135.11
Median target
$135.00
+0.2%
Mean target
$134.85
+0.1%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.08%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $-1.14 | $-1.09 | -0.05% |
| March 31, 2026 | $-1.06 | $-1.12 | 0.06% |
| Dec. 31, 2025 | $-1.03 | $-1.08 | 0.05% |
| Sept. 30, 2025 | $-1.11 | $-1.21 | 0.10% |
| June 30, 2025 | $-1.13 | $-1.10 | -0.03% |
| March 31, 2025 | $-0.95 | $-1.27 | 0.32% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| APGE | $5.16B | -17.9 | — | — | — | — |
| CYTK | $7.81B | -9.7 | 376.6% | -891.6% | 152.7% | — |
| PRAX | $7.43B | -21.9 | 249.5% | — | -47.3% | — |
| SMMT | $13.56B | -12.1 | — | — | -235.1% | — |
| PTGX | $5.47B | -42.6 | -89.4% | -282.8% | -20.3% | — |
| KYMR | $6.33B | -21.1 | -16.7% | -794.0% | -24.4% | — |
| KRYS | $7.20B | 36.0 | 33.9% | 52.6% | 18.1% | — |
| IONS | $12.92B | -33.2 | — | — | -68.1% | — |
| SYRE | $2.56B | 10.1 | -62.0% | — | -26.5% | — |
| IMVT | $5.07B | -9.0 | 229.2% | — | -73.7% | — |
| PCVX | $6.05B | -8.2 | — | — | -26.6% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 14
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| R&D Expense | $215M | $168M | $68M | $28M | |
| SG&A Expense | $71M | $49M | $25M | $3M | |
| Operating Expenses | $286M | $217M | $93M | $31M | |
| Operating Income | $-286M | $-217M | $-93M | $-31M | |
| Interest Income | $30M | $35M | $9M | $92.0K | |
| Other Non-op | $30M | $35M | $9M | $-9M | |
| Pretax Income | $-256M | $-182M | $-84M | · | |
| Income Tax | $278.0K | $18.0K | $0 | · | |
| Net Income | $-256M | $-182M | $-84M | $-40M | |
| EPS (Basic) | $-4.22 | $-3.30 | $-3.36 | $-16.16 | |
| EPS (Diluted) | $-4.22 | $-3.30 | $-3.36 | $-16.16 | |
| Shares (Basic) | 60,690,820 | 55,193,971 | 25,005,774 | 2,462,236 | |
| Shares (Diluted) | 60,690,820 | 55,193,971 | 25,005,774 | 2,462,236 | |
| EBITDA | $-286M | $-217M | $-93M | · |
Balance Sheet 20
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $132M | $142M | $118M | $152M | |
| Short-term Investments | $599M | $379M | $277M | · | |
| Prepaid Expense | $11M | $9M | $3M | $165.0K | |
| Other Current Assets | $605.0K | $2M | $1M | $57.0K | |
| Current Assets | $741M | $530M | $398M | $152M | |
| PP&E (Net) | $6M | $2M | $377.0K | · | |
| Accum. Depreciation | $2M | $189.0K | · | · | |
| Other Non-current Assets | $9M | $498.0K | $401.0K | · | |
| Total Assets | $937M | $754M | $401M | $152M | |
| Accounts Payable | $1M | $1M | $2M | $418.0K | |
| Accrued Liabilities | $23M | $24M | $17M | $10M | |
| Current Liabilities | $28M | $29M | $21M | $10M | |
| Capital Leases | $5M | $9M | $933.0K | · | |
| Total Liabilities | $33M | $37M | $21M | $10M | |
| Common Stock | $1.0K | $1.0K | · | · | |
| Paid-in Capital | $1.46B | $1.02B | $503M | · | |
| Retained Earnings | $-562M | $-306M | $-124M | $-40M | |
| AOCI | $1M | $915.0K | $329.0K | · | |
| Liabilities + Equity | $937M | $754M | $401M | $152M | |
| Shares Outstanding | 68,401,349 | 58,062,898 | 48,338,769 | 0 |
Cash Flow 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Stock-based Comp | $46M | $23M | $6M | $2M | |
| Operating Cash Flow | $-227M | $-171M | $-75M | $-16M | |
| CapEx | $5M | $1M | $167.0K | · | |
| Investing Cash Flow | $-180M | $-300M | $-274M | · | |
| Stock Issued | · | $450M | $315M | · | |
| Net Stock Activity | · | $450M | $315M | · | |
| Financing Cash Flow | $396M | $495M | $315M | $168M | |
| Net Change in Cash | $-11M | $23M | $-33M | $152M | |
| Taxes Paid | · | $360.0K | · | · | |
| Free Cash Flow | $-233M | $-172M | $-75M | · |
Profitability 1
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| ROA | -30.3% | -31.5% | -30.3% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 26.6 | 18.5 | 19.4 | · | |
| Quick Ratio | 26.2 | 18.2 | 19.2 | · |
Valuation (TTM) 6
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Net Income TTM | $-256M | $-182M | $-84M | · | |
| Market Cap | $5.16B | $2.63B | $1.35B | · | |
| P/E | -17.9 | -13.7 | -8.3 | · | |
| P / Cash Flow | -22.7 | -15.4 | -18.1 | · | |
| P / FCF | -22.2 | -15.3 | -18.0 | · | |
| Earnings Yield | -5.6% | -7.3% | -12.0% | · |
Income Statement 14
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $67M | $61M | $58M | $54M | $56M | $46M | $60M | $46M | $33M | $29M | $17M | $14M | $8M | |
| SG&A Expense | $24M | $22M | $20M | $17M | $17M | $17M | $16M | $13M | $11M | $9M | $7M | $5M | $4M | |
| Operating Expenses | $96M | $83M | $78M | $71M | $73M | $63M | $76M | $59M | $44M | $38M | $24M | $19M | $13M | |
| Operating Income | $-96M | $-83M | $-78M | $-71M | $-73M | $-63M | $-76M | $-59M | $-44M | $-38M | $-24M | $-19M | $-13M | |
| Interest Income | $12M | $9M | $9M | $6M | $7M | $8M | $9M | $10M | $10M | $6M | $3M | $0 | $133.0K | |
| Other Non-op | $10M | $9M | $9M | $6M | $7M | $8M | $9M | $10M | $10M | $6M | $3M | $0 | $133.0K | |
| Pretax Income | $-86M | $-74M | $-69M | $-65M | $-66M | $-55M | $-67M | $-49M | $-34M | $-32M | · | · | · | |
| Income Tax | $78.0K | $79.0K | $62.0K | $61.0K | $72.0K | $83.0K | $18.0K | $0 | $0 | $0 | · | · | · | |
| Net Income | $-86M | $-74M | $-69M | $-65M | $-66M | $-55M | $-67M | $-49M | $-34M | $-32M | $-21M | $-19M | $-13M | |
| EPS (Basic) | $-1.14 | $-1.06 | $-1.03 | $-1.11 | $-1.13 | $-0.95 | $-1.20 | $-0.86 | $-0.60 | $-0.64 | $-0.51 | $-3.78 | $-2.51 | |
| EPS (Diluted) | $-1.14 | $-1.06 | $-1.03 | $-1.11 | $-1.13 | $-0.95 | $-1.20 | $-0.86 | $-0.60 | $-0.64 | $-0.51 | $-3.78 | $-2.51 | |
| Shares (Basic) | 75,443,496 | 69,668,439 | -114,706,527 | 58,773,731 | 58,428,344 | 58,195,272 | -108,306,384 | 56,795,544 | 56,515,003 | 50,189,808 | 41,231,379 | 5,000,000 | 5,000,000 | |
| Shares (Diluted) | 75,443,496 | 69,668,439 | -114,706,527 | 58,773,731 | 58,428,344 | 58,195,272 | -108,306,384 | 56,795,544 | 56,515,003 | 50,189,808 | 41,231,379 | 5,000,000 | 5,000,000 | |
| EBITDA | $-96M | $-83M | · | $-71M | $-73M | $-63M | · | $-59M | $-44M | $-38M | $-24M | $-19M | · |
Balance Sheet 20
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $106M | $452M | $132M | $108M | $124M | $107M | $142M | $119M | $307M | $485M | · | $125M | · | |
| Short-term Investments | $866M | $608M | $599M | $419M | $381M | $406M | $379M | $407M | $369M | $331M | $235M | · | · | |
| Prepaid Expense | $20M | $14M | $11M | $13M | $11M | $8M | $9M | $8M | $6M | $4M | $4M | $6M | · | |
| Other Current Assets | $1M | $1M | $605.0K | $919.0K | $963.0K | $586.0K | $2M | $396.0K | $3M | $3M | $1M | $887.0K | · | |
| Current Assets | $992M | $1.07B | $741M | $540M | $516M | $522M | $530M | $534M | $682M | $821M | $426M | $131M | · | |
| PP&E (Net) | $5M | $5M | $6M | $6M | $6M | $6M | $2M | $1M | $714.0K | $699.0K | · | · | · | |
| Accum. Depreciation | $2M | $2M | $2M | $1M | $796.0K | $396.0K | $189.0K | $113.0K | · | · | · | · | · | |
| Other Non-current Assets | $11M | $9M | $9M | $9M | $9M | $7M | $498.0K | $514.0K | $468.0K | $401.0K | · | · | · | |
| Total Assets | $1.34B | $1.29B | $937M | $626M | $658M | $714M | $754M | $776M | $801M | $824M | $426M | $131M | · | |
| Accounts Payable | $3M | $1M | $1M | $376.0K | $6M | $2M | $1M | $2M | $6M | $4M | $1M | $11M | · | |
| Accrued Liabilities | $32M | $29M | $23M | $30M | $22M | $27M | $24M | $28M | $17M | $16M | $16M | $6M | · | |
| Current Liabilities | $38M | $33M | $28M | $34M | $32M | $33M | $29M | $33M | $25M | $22M | $17M | $18M | · | |
| Capital Leases | $4M | $5M | $5M | $6M | $7M | $8M | $9M | $9M | $2M | $630.0K | · | · | · | |
| Total Liabilities | $141M | $38M | $33M | $40M | $38M | $41M | $37M | $42M | $27M | $22M | $17M | $18M | · | |
| Common Stock | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | · | · | · | |
| Paid-in Capital | $1.92B | $1.89B | $1.46B | $1.08B | $1.05B | $1.03B | $1.02B | $970M | $964M | $958M | $501M | · | · | |
| Retained Earnings | $-722M | $-636M | $-562M | $-492M | $-427M | $-361M | $-306M | $-239M | $-190M | $-156M | $-92M | $-71M | · | |
| AOCI | $-3M | $-749.0K | $1M | $1M | $685.0K | $1M | $915.0K | $3M | $-289.0K | $-177.0K | $135.0K | · | · | |
| Liabilities + Equity | $1.34B | $1.29B | $937M | $626M | $658M | $714M | $754M | $776M | $801M | $824M | $426M | $131M | · | |
| Shares Outstanding | 75,339,499 | 74,882,396 | 68,401,349 | 59,315,738 | 58,560,525 | 58,304,801 | 58,062,898 | 56,899,295 | 56,676,465 | 56,367,802 | 48,017,621 | · | · |
Cash Flow 9
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $17M | $17M | $12M | $12M | $11M | $11M | $8M | $6M | $6M | $4M | $2M | $1M | $1M | |
| Operating Cash Flow | $-71M | $-56M | $-63M | $-54M | $-62M | $-48M | $-68M | $-43M | $-29M | $-32M | $-20M | $-15M | $-11M | |
| CapEx | · | · | $62.0K | $0 | $768.0K | $4M | $-1.0K | $751.0K | $51.0K | $351.0K | · | · | · | |
| Investing Cash Flow | $-382M | $-35M | $-289M | $18M | $78M | $13M | $46M | $-146M | $-149M | $-52M | · | · | · | |
| Stock Issued | $-728.0K | $378M | · | $0 | $0 | $0 | · | $0 | $-541.0K | $450M | · | · | · | |
| Net Stock Activity | · | $378M | · | · | · | $0 | · | · | · | $450M | · | · | · | |
| Financing Cash Flow | $107M | $411M | $375M | $20M | $1M | $622.0K | $44M | $383.0K | $-150.0K | $451M | $317M | · | · | |
| Net Change in Cash | $-346M | $320M | $24M | $-17M | $17M | $-35M | $23M | $-189M | $-178M | $367M | $63M | $-16M | $-11M | |
| Free Cash Flow | · | · | · | · | · | $-53M | · | · | · | $-32M | · | · | · |
Profitability 1
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -8.6% | -7.4% | · | -9.3% | -9.1% | -7.2% | · | -8.2% | -7.3% | -7.8% | -9.8% | -28.9% | · |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 26.4 | 32.6 | · | 15.9 | 16.4 | 15.8 | · | 16.4 | 27.7 | 38.1 | 24.8 | 7.4 | · | |
| Quick Ratio | 25.9 | 32.2 | · | 15.5 | 16.0 | 15.6 | · | 16.1 | 27.5 | 37.9 | 13.7 | 7.1 | · |
Valuation (TTM) 6
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-291M | $-261M | · | $-235M | $-204M | $-170M | · | $-136M | $-106M | $-84M | $-72M | $-53M | · | |
| Market Cap | $10.00B | $6.30B | · | $2.36B | $2.54B | $2.18B | · | $3.34B | $2.23B | $3.75B | $1.02B | · | · | |
| P/E | -29.9 | -19.8 | · | -9.8 | -12.3 | -12.2 | · | -22.5 | -7.1 | -8.9 | -1.3 | · | · | |
| P / Cash Flow | · | -113.4 | · | · | · | -44.9 | · | · | · | -118.4 | · | · | · | |
| P / FCF | · | · | · | · | · | -41.3 | · | · | · | -117.1 | · | · | · | |
| Earnings Yield | -3.4% | -5.1% | · | -10.2% | -8.2% | -8.2% | · | -4.4% | -14.1% | -11.2% | -76.3% | · | · |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Net Income | $-256M | $-182M | $-84M | $-40M |
| Diluted EPS | $-4.22 | $-3.30 | $-3.36 | $-16.16 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Current Ratio | 26.6 | 18.5 | 19.4 | — |
| Quick Ratio | 26.2 | 18.2 | 19.2 | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Free Cash Flow | $-233M | $-172M | $-75M | — |
Latest News Recent headlines mentioning this company
- Is AbbVie a Buy After Its Purchase of Apogee?
- AbbVie Just Sparked a 46% Rally in Apogee. Here’s Why This $10.9 Billion Deal Could Be a Win for AbbVie Investors.
- Apogee Therapeutics (APGE) Hits Fresh High on AbbVie $10.9B Merger
- The $11 Billion Reason Abbvie Stock Is Up Today
- Stock Market Today, June 22: Apogee Therapeutics Soars on AbbVie Cash Buyout Offer
- AbbVie to acquire Apogee Therapeutics in $10.9B deal
- VR Adviser Adds Over 1 Million Savara Shares
My Metrics Your personal watchlist — selected rows from Full Fundamentals
📊
Pick the metrics that matter to you — click the ➕ next to any row in Full Fundamentals above.
Your selection is saved and follows you across all tickers.
Institutional owners (13F) 316 filers · $7.1B total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 130 (+75 vs prior Q) | 47 (+20 vs prior Q) | 81 (-23 vs prior Q) | 67 (+17 vs prior Q) | -4.7M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Venrock Adviser, LLC | $1,127,318,496 | 8,493,321 | 15.92% | Shares |
| HBK INVESTMENTS L P | $378,280,500 | 2,850,000 | 5.34% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $341,397,355 | 2,572,119 | 4.82% | Shares |
| STATE STREET CORP | $304,979,428 | 2,297,743 | 4.31% | Shares |
| FMR LLC | $241,465,867 | 1,819,226 | 3.41% | Shares |
| Driehaus Capital Management LLC | $230,963,606 | 1,740,101 | 3.26% | Shares |
| Balyasny Asset Management L.P. | $221,006,068 | 1,665,080 | 3.12% | Shares |
| Paradigm Biocapital Advisors LP | $209,233,581 | 1,576,385 | 2.95% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $202,910,988 | 1,528,750 | 2.86% | Shares |
| GOLDMAN SACHS GROUP INC | $201,319,157 | 1,516,757 | 2.84% | Shares |
| MILLENNIUM MANAGEMENT LLC | $197,954,053 | 1,491,404 | 2.79% | Shares |
| Pentwater Capital Management LP | $189,140,250 | 1,425,000 | 2.67% | Shares |
| PERCEPTIVE ADVISORS LLC | $173,625,838 | 1,308,113 | 2.45% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $149,266,292 | 1,124,299 | 2.11% | Shares |
| Affinity Asset Advisors, LLC | $131,004,510 | 987,000 | 1.85% | Shares |
| MERCER GLOBAL ADVISORS INC /ADV | $124,936,493 | 941,283 | 1.76% | Shares |
| First Light Asset Management, LLC | $123,477,259 | 930,289 | 1.74% | Shares |
| Kryger Capital LLC | $98,559,325 | 742,555 | 1.39% | Shares |
| Qube Research & Technologies Ltd | $87,559,061 | 659,678 | 1.24% | Shares |
| First Trust Capital Management L.P. | $82,980,407 | 625,182 | 1.17% | Shares |
| Remedium Capital Partners, LLC | $77,871,496 | 586,691 | 1.10% | Shares |
| BANK OF AMERICA CORP /DE/ | $76,695,907 | 577,834 | 1.08% | Shares |
| SOROS FUND MANAGEMENT LLC | $74,926,085 | 564,500 | 1.06% | Shares |
| Balyasny Asset Management L.P. | $66,365,000 | 500,000 | 0.94% | Put option |
| ALLIANCEBERNSTEIN L.P. | $65,236,632 | 775,058 | 0.92% | Shares |
| Woodline Partners LP | $61,669,278 | 464,622 | 0.87% | Shares |
| WHITEBOX ADVISORS LLC | $59,728,633 | 450,001 | 0.84% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $58,886,726 | 443,658 | 0.83% | Shares |
| AQR Arbitrage LLC | $57,060,627 | 429,900 | 0.81% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $52,186,781 | 393,180 | 0.74% | Shares |
| Opaleye Management Inc. | $51,764,700 | 390,000 | 0.73% | Shares |
| TIG Advisors, LLC | $48,346,902 | 364,250 | 0.68% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $48,264,344 | 363,628 | 0.68% | Shares |
| Cinctive Capital Management LP | $46,477,400 | 350,165 | 0.66% | Shares |
| Polar Asset Management Partners Inc. | $42,801,045 | 322,467 | 0.60% | Shares |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $40,315,285 | 303,739 | 0.57% | Shares |
| Fairmount Funds Management LLC | $39,639,416 | 298,647 | 0.56% | Shares |
| NEXPOINT ASSET MANAGEMENT, L.P. | $38,814,234 | 292,430 | 0.55% | Shares |
| Squarepoint Ops LLC | $38,586,336 | 290,713 | 0.54% | Shares |
| CITIGROUP INC | $38,075,061 | 286,861 | 0.54% | Shares |
| LOOMIS SAYLES & CO L P | $37,377,830 | 281,608 | 0.53% | Shares |
| Magnetar Financial LLC | $36,502,741 | 275,015 | 0.52% | Shares |
| Slotnik Capital, LLC | $34,608,020 | 260,740 | 0.49% | Shares |
| Man Group plc | $34,552,274 | 260,320 | 0.49% | Shares |
| EVENTIDE ASSET MANAGEMENT, LLC | $34,509,800 | 260,000 | 0.49% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $33,182,500 | 250,000 | 0.47% | Shares |
| D. E. Shaw & Co., Inc. | $32,107,785 | 241,903 | 0.45% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $27,901,439 | 210,212 | 0.39% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $26,917,644 | 202,800 | 0.38% | Put option |
| PICTON MAHONEY ASSET MANAGEMENT | $26,546,000 | 200,000 | 0.37% | Put option |
| VANGUARD GROUP INC | $24,556,890 | 325,343 | 0.35% | Shares |
| MUFG Securities EMEA plc | $23,957,765 | 180,500 | 0.34% | Shares |
| Allianz Asset Management GmbH | $23,493,210 | 177,000 | 0.33% | Shares |
| PICTON MAHONEY ASSET MANAGEMENT | $21,900,456 | 165,000 | 0.31% | Shares |
| Verition Fund Management LLC | $21,138,049 | 159,256 | 0.30% | Shares |
| BlackRock, Inc. | $20,914,133 | 157,569 | 0.30% | Shares |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | $20,668,197 | 155,857 | 0.29% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $19,484,764 | 146,800 | 0.28% | Shares |
| First Turn Management, LLC | $18,425,844 | 138,822 | 0.26% | Shares |
| Grantham, Mayo, Van Otterloo & Co. LLC | $18,236,438 | 137,395 | 0.26% | Shares |
| Sagefield Capital LP | $17,970,846 | 135,394 | 0.25% | Shares |
| GABELLI FUNDS LLC | $16,894,007 | 127,281 | 0.24% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $16,094,574 | 121,258 | 0.23% | Shares |
| CAPSTONE INVESTMENT ADVISORS, LLC | $15,927,600 | 120,000 | 0.22% | Shares |
| Twin Securities, Inc. | $15,927,600 | 120,000 | 0.22% | Shares |
| Melqart Asset Management (UK) Ltd | $15,562,460 | 117,249 | 0.22% | Shares |
| Caption Management, LLC | $15,356,861 | 115,700 | 0.22% | Put option |
| TUDOR INVESTMENT CORP ET AL | $13,352,638 | 100,600 | 0.19% | Put option |
| SEVEN GRAND MANAGERS, LLC | $13,273,000 | 100,000 | 0.19% | Shares |
| WATER ISLAND CAPITAL LLC | $12,596,077 | 94,900 | 0.18% | Shares |
| TWO SIGMA INVESTMENTS, LP | $12,577,362 | 94,759 | 0.18% | Shares |
| Maven Securities LTD | $12,080,819 | 91,018 | 0.17% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $11,674,002 | 87,953 | 0.16% | Shares |
| ExodusPoint Capital Management, LP | $11,608,625 | 87,500 | 0.16% | Call option |
| GABELLI & Co INVESTMENT ADVISERS, INC. | $10,836,741 | 81,645 | 0.15% | Shares |
| GARDNER LEWIS ASSET MANAGEMENT L P | $10,618,400 | 80,000 | 0.15% | Shares |
| Candriam S.C.A. | $10,566,281 | 79,684 | 0.15% | Shares |
| HARVEST MANAGEMENT LLC | $10,485,670 | 79,000 | 0.15% | Shares |
| Swiss National Bank | $10,180,391 | 76,700 | 0.14% | Shares |
| WCM INVESTMENT MANAGEMENT, LLC | $10,074,912 | 75,974 | 0.14% | Shares |
| Alberta Investment Management Corp | $9,954,750 | 75,000 | 0.14% | Shares |
| Chicago Capital Management, LLC | $9,807,420 | 97,100 | 0.14% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9,768,928 | 73,600 | 0.14% | Call option |
| Boxer Capital Management, LLC | $9,291,100 | 70,000 | 0.13% | Shares |
| PRUDENTIAL FINANCIAL INC | $8,510,648 | 64,120 | 0.12% | Shares |
| KENNEDY CAPITAL MANAGEMENT LLC | $8,492,198 | 63,981 | 0.12% | Shares |
| CREDIT INDUSTRIEL ET COMMERCIAL | $8,418,268 | 63,424 | 0.12% | Shares |
| ALPS ADVISORS INC | $8,298,678 | 62,523 | 0.12% | Shares |
| Westchester Capital Management, LLC | $8,253,417 | 62,182 | 0.12% | Shares |
| Beryl Capital Management LLC | $7,788,065 | 58,676 | 0.11% | Shares |
| PRELUDE CAPITAL MANAGEMENT, LLC | $7,776,651 | 58,590 | 0.11% | Shares |
| PLATINUM INVESTMENT MANAGEMENT LTD | $7,740,017 | 58,314 | 0.11% | Shares |
| ALPINE ASSOCIATES MANAGEMENT INC. | $7,685,067 | 57,900 | 0.11% | Shares |
| RHUMBLINE ADVISERS | $7,514,630 | 56,616 | 0.11% | Shares |
| Point72 Asset Management, L.P. | $7,241,616 | 54,559 | 0.10% | Shares |
| FIRST TRUST ADVISORS LP | $7,073,447 | 53,292 | 0.10% | Shares |
| ABC ARBITRAGE SA | $7,023,806 | 52,918 | 0.10% | Shares |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $6,755,957 | 50,900 | 0.10% | Shares |
| Centiva Capital, LP | $6,650,038 | 50,102 | 0.09% | Shares |
| Symmetry Investments LP | $6,636,500 | 50,000 | 0.09% | Call option |
Company insiders 9 insiders · 2 officers · 7 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Michael Thomas Henderson | Chief Executive Officer | July 10, 2026 G | 920,941 | 0 | 33 | $-28,389,804 |
| Jane Henderson | Chief Financial Officer | July 24, 2026 G | 158,371 | 0 | 22 | $-2,092,806 |
| Lisa Bollinger | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Jennifer A. Fox | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Mark C. Mckenna | Director | June 9, 2026 A | 20,000 | 0 | 0 | $0 |
| Nimish P Shah | Director | June 9, 2026 A | 1,750,000 | 0 | 0 | $0 |
| William A Jones JR | Director | June 9, 2026 A | — | 0 | 0 | $0 |
| Andrew Gottesdiener | Director | June 17, 2025 A | — | 0 | 0 | $0 |
| Carl Dambkowski | — | Aug. 5, 2026 M | 168,498 | 0 | 29 | $-10,257,229 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 2 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P., Peter Evan Harwin, Tomas Kiselak ×7 filings | June 23, 2026 | 9.99% | Amendment | M&A / sale | SEC |
| Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Shah, Nimish, Koh, Bong | July 28, 2023 | — | Initial filing | Passive investment | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 49 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 2.93% | 57,722 NS | May 31, 2026 | N-PORT |
| GDOC · Goldman Sachs ETF Trust | 1.97% | 4,823 NS | May 31, 2026 | N-PORT |
| GURU · Global X Funds | 1.29% | 9,059 NS | April 30, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 1.04% | 65,006 NS | April 30, 2026 | N-PORT |
| JDOC · J.P. Morgan Exchange-Traded Fund Tr… | 0.86% | 1,152 NS | April 30, 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0.79% | 3,580 NS | April 30, 2026 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund VI… | 0.64% | 4,048 NS | May 31, 2026 | N-PORT |
| IBB · iShares Trust | 0.59% | 418,176 SH | Aug. 8, 2026 | Daily |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.57% | 3,368 SH | Aug. 8, 2026 | Daily |
| FSCC · Federated Hermes ETF Trust | 0.50% | 16,880 NS | May 31, 2026 | N-PORT |
| IWO · iShares Trust | 0.37% | 408,942 SH | Aug. 8, 2026 | Daily |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.35% | 48,245 SH | Aug. 8, 2026 | Daily |
| BIB · ProShares Trust | 0.23% | 2,028 NS | May 31, 2026 | N-PORT |
| IWM · iShares Trust | 0.19% | 1,143,929 SH | Aug. 8, 2026 | Daily |
| BKSE · BNY Mellon ETF Trust | 0.19% | 1,817 NS | April 30, 2026 | N-PORT |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.18% | 259,546 SH | Aug. 8, 2026 | Daily |
| BBSC · J.P. Morgan Exchange-Traded Fund Tr… | 0.17% | 15,226 NS | April 30, 2026 | N-PORT |
| ISCG · iShares Trust | 0.17% | 12,662 SH | Aug. 8, 2026 | Daily |
| RSSL · Global X Funds | 0.11% | 19,243 NS | April 30, 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.09% | 258,020 NS | May 31, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.09% | 2,095 NS | May 31, 2026 | N-PORT |
| ISCB · iShares Trust | 0.08% | 1,801 SH | Aug. 8, 2026 | Daily |
| VXF · VANGUARD INDEX FUNDS | 0.08% | 641,337 SH | Aug. 8, 2026 | Daily |
| VBR · VANGUARD INDEX FUNDS | 0.08% | 428,167 SH | Aug. 8, 2026 | Daily |
| ESML · iShares Trust | 0.08% | 17,140 SH | Aug. 8, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | 0.07% | 114,655 SH | Aug. 8, 2026 | Daily |
| UWM · ProShares Trust | 0.05% | 1,637 NS | May 31, 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.05% | 11,341 SH | Aug. 8, 2026 | Daily |
| FHLC · FIDELITY COVINGTON TRUST | 0.05% | 17,612 NS | April 30, 2026 | N-PORT |
| VB · VANGUARD INDEX FUNDS | 0.05% | 674,464 SH | Aug. 8, 2026 | Daily |
| WSML · iShares Trust | 0.05% | 2,338 SH | Aug. 8, 2026 | Daily |
| AVIE · AMERICAN CENTURY ETF TRUST | 0.05% | 58 NS | May 31, 2026 | N-PORT |
| GSSC · Goldman Sachs ETF Trust | 0.04% | 4,882 NS | May 31, 2026 | N-PORT |
| URTY · ProShares Trust | 0.04% | 1,660 NS | May 31, 2026 | N-PORT |
| SMLF · iShares Trust | 0.03% | 10,566 SH | Aug. 8, 2026 | Daily |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.02% | 1,535 NS | May 31, 2026 | N-PORT |
| HDG · ProShares Trust | 0.02% | 42 NS | May 31, 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0.01% | 15,716 NS | May 31, 2026 | N-PORT |
| FBCG · FIDELITY COVINGTON TRUST | 0.01% | 8,874 NS | April 30, 2026 | N-PORT |
| ITOT · iShares Trust | 0.01% | 75,741 SH | Aug. 8, 2026 | Daily |
| VTI · VANGUARD INDEX FUNDS | 0.01% | 1,871,044 SH | Aug. 8, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.01% | 3,673 SH | Aug. 8, 2026 | Daily |
| IWV · iShares Trust | 0.01% | 11,143 SH | Aug. 8, 2026 | Daily |
| SCHB · SCHWAB STRATEGIC TRUST | 0.01% | 31,667 NS | May 31, 2026 | N-PORT |
| TILT · FlexShares Trust | 0.00% | 924 NS | April 30, 2026 | N-PORT |
| AVLC · AMERICAN CENTURY ETF TRUST | 0.00% | 106 NS | May 31, 2026 | N-PORT |
| AVSU · AMERICAN CENTURY ETF TRUST | 0.00% | 17 NS | May 31, 2026 | N-PORT |
| AVUS · AMERICAN CENTURY ETF TRUST | 0.00% | 52 NS | May 31, 2026 | N-PORT |
| FTLS · First Trust Exchange-Traded Fund III | -0.06% | -17,470 NS | April 30, 2026 | N-PORT |