your badges 52W Range $1–$2 2% of range Analyst Rating HOLD 10 analysts Price Target $2 +93% upside P/E -0.4 ROE -74.4% Net Profit Margin ·

PLRX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $1.03
Market Cap (MRQ) $64M
P/E -0.4
EPS $-2.43
Revenue $0
ROE -74.4%
52W Range $1–$2

PLRX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
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About Pliant Therapeutics, Inc. - Common Stock Company overview from Wikipedia

05 · wikidata
sectorHealthcare industryPharmaceuticals employees49 countryUS

10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$0
2019-12-31 → 2025-12-31
EPS$-2.43
2019-12-31 → 2025-12-31
Free Cash Flow$-129M
2020-12-31 → 2025-12-31
Net margin·
2020-12-31 → 2023-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend PLRX 5Y avg Peer Median Verdict
P/E -0.45Y avg ≈-4.5 ≈-4.5 · ·
P/B (MRQ) 0.45Y avg ≈2.1 ≈2.1 3.9 Undervalued
Price / FCF (TTM) -0.95Y avg ≈-6.2 ≈-6.2 · ·
Price / Cash Flow (TTM) -0.95Y avg ≈-6.3 ≈-6.3 · ·
Price / Tangible Book 0.45Y avg ≈2.1 ≈2.1 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise 0.86%
Next Report Nov 04, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 5, 2026 $-0.36 $-0.35 -3.2%
March 31, 2026 May 6, 2026 $-0.32 $-0.36 12.0%
Dec. 31, 2025 $-0.38 $-0.39 1.5%
Sept. 30, 2025 $-0.43 $-0.53 19.5%
June 30, 2025 $-0.71 $-0.71 -0.10%
March 31, 2025 $-0.92 $-0.74 -24.5%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

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Income Statement 15
Metric Trend 2025202420232022202120202019
Revenue $0$0$2M$10M$8M$42M$57M
R&D Expense $109M$169M$128M$97M$78M$66M$47M
SG&A Expense $47M$59M$58M$40M$28M$17M$11M
Operating Expenses $156M$228M$186M$137M$105M$83M$58M
Operating Income $-156M$-228M$-184M$-127M$-98M$-42M$-1M
Interest Expense ··$1M$791.0K$0··
Interest Income ·····$478.0K$816.0K
Other Non-op ·····$-366.0K$-216.0K
Income Tax $0$0$0$0$0$0$0
Net Income $-149M$-210M$-161M$-123M$-97M$-42M$-631.0K
EPS (Basic) $-2.43$-3.47$-2.75$-2.94$-2.71$-1.95$-4.22
EPS (Diluted) $-2.43$-3.47$-2.75$-2.94$-2.71$-1.95$-4.22
Shares (Basic) 61,366,88760,538,63958,719,08342,015,90835,846,42121,344,2361,623,358
Shares (Diluted) 61,366,88760,538,63958,719,08342,015,90835,846,42121,344,2361,623,358
EBITDA $-156M$-228M$-184M$-127M·$-42M·
Balance Sheet 23
Metric Trend 2025202420232022202120202019
Cash & Equivalents $45M$71M$63M$34M$52M$51M$86M
Short-term Investments $145M$285M$431M$298M$149M$226M$17M
Receivables ··$0$2M$2M$9M$7M
Prepaid Expense $4M$7M$11M$7M$7M$4M$2M
Current Assets $196M$362M$506M$340M$209M$291M$112M
PP&E (Net) $3M$6M$4M$4M$5M$4M$4M
PP&E (Gross) $14M$16M$12M$11M$10M$8M$6M
Accum. Depreciation $11M$11M$9M$7M$5M$3M$2M
Other Non-current Assets $392.0K$435.0K$392.0K$394.0K$838.0K$451.0K$3M
Total Assets $225M$397M$512M$351M$221M$296M$119M
Accounts Payable $480.0K$6M$5M$2M$3M$2M$1M
Accrued Liabilities $10M$12M$10M$9M$12M$10M$7M
Current Liabilities $16M$33M$29M$24M$17M$12M$8M
Capital Leases $28M$29M$0$3M$5M$0·
Other Non-current Liabilities ····$0$866.0K$912.0K
Total Liabilities $44M$93M$39M$37M$22M$12M$9M
Long-term Debt $0$30M$10M$10M$0··
Common Stock $6.0K$6.0K$6.0K$5.0K$3.0K$3.0K$1.0K
Retained Earnings $-859M$-710M$-500M$-338M$-215M$-118M$-76M
AOCI $-15.0K$321.0K$345.0K$-2M$-201.0K$-32.0K$-1.0K
Stockholders' Equity $181M$304M$474M$313M$199M$283M$-76M
Liabilities + Equity $225M$397M$512M$351M$221M$296M$119M
Shares Outstanding 61,449,29060,860,83859,921,00248,941,25436,083,30135,552,7951,846,024
Cash Flow 8
Metric Trend 2025202420232022202120202019
Stock-based Comp $26M$38M$44M$23M$10M$4M$2M
Operating Cash Flow $-128M$-156M$-116M$-95M$-75M$-37M$-3M
CapEx $374.0K$4M$921.0K$2M$2M$2M$964.0K
Investing Cash Flow $134M$140M$-127M$-150M$74M$-211M$-18M
Financing Cash Flow $-32M$23M$274M$227M$3M$213M$46M
Net Change in Cash $-26M$8M$31M$-18M$783.0K$-35M$25M
Taxes Paid $0$0·····
Free Cash Flow $-129M$-159M$-117M$-96M·$-39M·
Profitability 5
Metric Trend 2025202420232022202120202019
Operating Margin ··-11654.8%-1313.4%·-99.6%·
Net Margin ··-10211.1%-1273.3%·-99.3%·
EBITDA Margin ··-11654.8%-1313.4%·-99.6%·
ROA -48.0%-46.3%-37.4%-43.1%·-20.0%·
ROE -74.4%-64.7%-33.0%-37.9%·-14.2%·
Liquidity & Solvency 3
Metric Trend 2025202420232022202120202019
Current Ratio 12.010.917.714.2·25.1·
Quick Ratio 11.710.717.313.9·24.7·
Interest Coverage ··-145.3····
Efficiency 2
Metric Trend 2025202420232022202120202019
Asset Turnover 0.00.00.00.0·0.2·
Receivables Turnover ··1.64.9·5.1·
Per Share 7
Metric Trend 2025202420232022202120202019
Book Value / Share $2.95$5.00$7.90$6.40·$7.96·
Revenue / Share $0.00$0.00$0.03$0.23·$1.96·
Cash Flow / Share $-2.09$-2.57$-1.98$-2.25·$-1.75·
Cash / Share $0.74$1.17$1.06$0.69·$1.43·
Dividend / Share $0.00$0.00$0.00$0.00·$0.00·
Dividend Paid / Share $0.00$0.00$0.00$0.00$0.00$0.00·
EPS (TTM) $-2.43$-3.47$-2.75$-2.94$-2.71$-1.95·
Growth Rates 2
Metric Trend 2025202420232022202120202019
Revenue YoY ··-83.7%27.9%-81.9%··
Revenue CAGR 3Y ··-66.4%····
Valuation (TTM) 10
Metric Trend 2025202420232022202120202019
Revenue TTM $0$0$2M$10M$8M$42M·
Net Income TTM $-149M$-210M$-161M$-123M$-97M$-42M·
Market Cap $75M$802M$1.09B$946M·$808M·
P/E -0.5-3.8-6.6-6.6-5.0-11.7·
P/S ··686.897.7·19.3·
P/B 0.42.62.33.0·2.9·
P / Tangible Book 0.42.62.33.0·2.9·
P / Cash Flow -0.6-5.2-9.3-10.0·-21.7·
P / FCF -0.6-5.0-9.3-9.8·-20.8·
Earnings Yield -199.2%-26.4%-15.2%-15.2%-20.1%-8.6%·

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0 $0 $2M $10M $8M
Operating Margin % · · -11654.8% -1313.4% ·
Net Income $-149M $-210M $-161M $-123M $-97M
Diluted EPS $-2.43 $-3.47 $-2.75 $-2.94 $-2.71

Institutional owners (13F) 99 filers · $56.9M total · As of June 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 99
Value held $56.9M
New positions 12
Exited positions 12
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
12 (-2 vs prior Q) 12 (-1 vs prior Q) 18 (-8 vs prior Q) 27 (0 vs prior Q) -1.3M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
TANG CAPITAL MANAGEMENT LLC $7,001,038 6,141,261 12.30% Shares
ADAR1 Capital Management, LLC $6,281,085 5,509,724 11.04% Shares
VANGUARD GROUP INC $3,438,255 2,818,241 6.04% Shares
VANGUARD CAPITAL MANAGEMENT LLC $2,782,000 2,440,351 4.89% Shares
TWO SIGMA INVESTMENTS, LP $2,579,628 2,262,832 4.53% Shares
CITADEL ADVISORS LLC $2,442,138 2,142,226 4.29% Shares
RENAISSANCE TECHNOLOGIES LLC $2,336,856 2,049,874 4.11% Shares
Monaco Asset Management SAM $2,210,172 1,938,747 3.88% Shares
Lynx1 Capital Management LP $2,049,800 1,798,070 3.60% Shares
BML Capital Management, LLC $1,762,596 1,546,137 3.10% Shares
Prosight Management, LP $1,562,066 1,370,233 2.74% Shares
TWO SIGMA ADVISERS, LP $1,519,632 1,245,600 2.67% Shares
Peapod Lane Capital LLC $1,492,275 1,309,013 2.62% Shares
Woodline Partners LP $1,478,049 1,296,534 2.60% Shares
BlackRock, Inc. $1,312,384 1,151,214 2.31% Shares
Ikarian Capital, LLC $1,140,000 1,000,000 2.00% Shares
Eversept Partners, LP $1,016,224 891,425 1.79% Shares
MARSHALL WACE, LLP $952,041 835,124 1.67% Shares
Redmile Group, LLC $880,224 772,126 1.55% Shares
JPMORGAN CHASE & CO $783,894 681,647 1.38% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $733,157 643,120 1.29% Shares
GEODE CAPITAL MANAGEMENT, LLC $659,954 578,577 1.16% Shares
UBS Group AG $651,806 571,760 1.15% Shares
MILLENNIUM MANAGEMENT LLC $637,770 559,447 1.12% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $631,138 553,630 1.11% Shares
Connor, Clark & Lunn Investment Management Ltd. $611,132 536,081 1.07% Shares
DAFNA Capital Management LLC $555,180 487,000 0.98% Shares
XTX Topco Ltd $502,562 440,844 0.88% Shares
Laurion Capital Management LP $470,587 412,796 0.83% Shares
TORNO CAPITAL, LLC $400,647 351,445 0.70% Shares
VANGUARD FIDUCIARY TRUST CO $389,596 341,751 0.68% Shares
BOOTHBAY FUND MANAGEMENT, LLC $345,420 303,000 0.61% Shares
MORGAN STANLEY $340,833 298,976 0.60% Shares
SEI INVESTMENTS CO $338,909 297,291 0.60% Shares
Verdad Advisers, LP $320,731 281,343 0.56% Shares
ArrowMark Colorado Holdings LLC $320,555 281,189 0.56% Shares
NANO CAP NEW MILLENNIUM GROWTH FUND L P $313,500 275,000 0.55% Shares
STATE STREET CORP $288,897 253,418 0.51% Shares
Stonepine Capital Management, LLC $262,813 230,538 0.46% Shares
Rangeley Capital, LLC $256,500 225,000 0.45% Shares
GOLDMAN SACHS GROUP INC $237,787 208,585 0.42% Shares
Congress Wealth Management LLC / DE / $231,907 199,920 0.41% Shares
Marquette Asset Management, LLC $198,930 174,500 0.35% Shares
HighMark Wealth Management LLC $189,495 166,224 0.33% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $175,232 153,712 0.31% Shares
JANE STREET GROUP, LLC $148,144 129,951 0.26% Shares
NORTHERN TRUST CORP $142,568 125,060 0.25% Shares
ALGERT GLOBAL LLC $140,678 123,402 0.25% Shares
OSAIC HOLDINGS, INC. $131,013 114,924 0.23% Shares
Invesco Ltd. $119,333 104,678 0.21% Shares

Show all 99 institutional owners →

Activists & 5%+ owners 1 position

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
TANG CAPITAL MANAGEMENT, LLC, KEVIN TANG, TANG CAPITAL PARTNERS, LP, TANG CAPITAL PARTNERS INTERNATIONAL, LP, TANG CAPITAL PARTNERS III, INC, TANG CAPITAL PARTNERS IV, INC, CONCENTRA BIOSCIENCES, LLC March 10, 2025 9.60% Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 23 insiders · 9 officers · 14 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Bernard Coulie President and CEO April 17, 2026 A 505,601 0 1 $-114,400
Keith Lamont Cummings Chief Financial Officer April 17, 2026 A 297,214 0 1 $-30,723
Minnie Kuo Chief Operating Officer April 17, 2026 A 37,806 0 1 $-8,854
David Raben Chief Medical Officer Oct. 1, 2026 A · 0 0 $0
Lily Cheung Chief Human Resource Officer April 17, 2026 A 44,847 0 1 $-9,644
Mike Ouimette General Counsel & Corp. Sec'y Jan. 23, 2025 A 105,544 0 0 $0
Hans Hull Chief Business Officer Jan. 23, 2025 A 251,708 0 0 $0
Eric Lefebvre Chief Medical Officer Jan. 23, 2025 A 240,224 0 0 $0
Barbara Howes Chief Human Resource Officer Jan. 23, 2021 A 24,799 0 0 $0
Flavia Borellini Director July 9, 2026 A · 0 0 $0
Robert Iannone Director July 9, 2026 A · 0 0 $0
Steve E. Krognes Director June 11, 2026 A · 0 0 $0
Darren S Cline Director June 11, 2026 A · 0 0 $0
John T Curnutte Director June 11, 2026 A · 0 0 $0
Thomas A Mccourt Director June 11, 2026 A · 0 0 $0
Hoyoung Huh Director June 11, 2026 A 239,619 0 0 $0
Gayle A Crowell Director June 11, 2026 A · 0 0 $0
Katharine Knobil Director June 5, 2025 A · 0 0 $0
Suzanne Louise Bruhn Director June 5, 2025 A · 0 0 $0
David E I Pyott Director June 5, 2025 A · 0 0 $0
Smital Shah Director June 13, 2024 A · 0 0 $0
Neil Exter Director June 16, 2022 A 0 0 0 $0
Charles J Homcy · June 29, 2021 A · 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 5 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.02% 205,246 SH Sept. 11, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.00% 22,250 SH Sept. 29, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.00% 615,799 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 1,746,470 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.00% 153,712 SH Aug. 19, 2026 Daily

PLRX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 10 analysts SELL
Median target $2.00 +93.2%
0 0.0% Strong Buy
0 0.0% Buy
6 60.0% Hold
2 20.0% Sell
2 20.0% Strong Sell

12-Month Price Target

1 analysts · 2026-09-27

Mean target $2.00 +93.2%

Low$2.00 Mean$2.00 High$2.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
PLRX $75M -0.5 -83.7% · -74.4% ·
NTHI · -2.6 -51.8% · · ·
TELO $46M -4.0 · · -325.7% ·
VRCA $143M -4.9 370.2% -50.3% -492.8% ·
RFL · -1.6 44.0% -3328.2% -34.6% ·
CING · · · · · ·
ELOX · · · · 30.1% ·
HYPD $31M -0.4 1318.8% -5570.6% -115.6% 62.7%
TLPH $56M · · -51035.7% -120.8% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Aug 11, 2026