AXSM Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $179.25
Market Cap (MRQ) $9.37B
P/E (TTM) -47.9
EPS (TTM) $-3.74
Revenue (TTM) $777M
ROE (TTM) -245.1%
Debt/Equity (MRQ) 2.3
52W Range $117–$260

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10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$638M
2022-12-31 → 2025-12-31
EPS$-3.68
2020-12-31 → 2025-12-31
Free Cash Flow$-94M
2016-12-31 → 2025-12-31
Net margin-24.7%
2023-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend AXSM 5Y avg Peer Median Verdict
P/E (TTM) -47.95Y avg ≈-21.3 ≈-21.3 · ·
P/S (TTM) 12.15Y avg ≈26.6 ≈26.6 16.5 Fair value
P/B (MRQ) 112.55Y avg ≈63.8 ≈63.8 7.5 Overvalued
EV / EBITDA -53.95Y avg ≈-22.7 ≈-22.7 · ·
Price / FCF (TTM) -130.35Y avg ≈-39.7 ≈-39.7 · ·
Price / Cash Flow (TTM) -131.65Y avg ≈-39.9 ≈-39.9 · ·
EV / Revenue 14.15Y avg ≈25.7 ≈25.7 · ·
EV / FCF -95.75Y avg ≈-38.7 ≈-38.7 · ·
Price / Tangible Book (MRQ) 204.05Y avg ≈116.6 ≈116.6 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -3.0%
Next Report Nov 02, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 10, 2026 $-0.99 $-0.86 -14.9%
March 31, 2026 $-1.26 $-0.91 -37.9%
Dec. 31, 2025 $-0.56 $-0.68 18.0%
Sept. 30, 2025 $-0.94 $-0.88 -6.5%
June 30, 2025 $-0.97 $-1.12 13.3%
March 31, 2025 $-1.22 $-1.35 9.8%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 16
Metric Trend 2025202420232022
Revenue $638M$386M$271M$50M
Cost of Revenue ···$5M
R&D Expense $183M$187M$98M$58M
SG&A Expense $571M$411M$323M$159M
Operating Expenses $805M$666M$502M$230M
Operating Income $-167M$-281M$-232M$-180M
Interest Expense $-16M$-22M$-20M$-10M
Interest Income $9M$15M$14M$2M
Pretax Income $-184M$-287M$-238M$-187M
Income Tax $-530.0K$85.0K$960.0K$0
Net Income $-183M$-287M$-239M$-187M
EPS (Basic) $-3.68$-5.99$-5.27$-4.60
EPS (Diluted) $-3.68$-5.99$-5.27$-4.60
Shares (Basic) 49,747,17847,914,25345,425,21240,655,941
Shares (Diluted) 49,747,17847,914,25345,425,21240,655,941
EBITDA $-167M$-281M$-232M$-180M
Balance Sheet 20
Metric Trend 2025202420232022
Cash & Equivalents $323M$315M$386M$201M
Receivables $224M$142M$95M$38M
Inventory $28M$16M$15M$4M
Prepaid Expense $14M$12M$8M$3M
Current Assets $589M$485M$504M$246M
PP&E (Net) $562.0K$584.0K$846.0K$722.0K
Goodwill $12M$12M$12M$10M
Intangibles $41M$47M$53M$60M
Total Assets $690M$568M$588M$331M
Accounts Payable $66M$72M$41M$39M
Current Liabilities $379M$230M$139M$97M
Capital Leases $23M$6M$7M·
Total Liabilities $602M$511M$397M$222M
Long-term Debt $188M$181M··
Total Debt $188M$181M$178M$94M
Common Stock $5.0K$5.0K$5.0K$4.0K
Retained Earnings $-1.31B$-1.12B$-836M$-596M
Stockholders' Equity $88M$57M$191M$110M
Liabilities + Equity $690M$568M$588M$331M
Shares Outstanding 50,882,76648,667,58747,351,36343,498,617
Cash Flow 13
Metric Trend 2025202420232022
Stock-based Comp $94M$85M$63M$38M
Amort. of Intangibles $6M$6M$6M$4M
Operating Cash Flow $-93M$-128M$-145M$-117M
CapEx $480.0K$270.0K$582.0K$702.0K
Investing Cash Flow $-480.0K$-270.0K$-582.0K$-54M
Net Debt Issued $-332M···
Stock Issued $68M$41M$259M$244M
Net Stock Activity $68M$41M$259M$237M
Financing Cash Flow $101M$58M$331M$285M
Net Change in Cash $8M$-71M$185M$114M
Taxes Paid $-180.0K···
Free Cash Flow $-94M$-129M$-146M$-117M
Levered FCF $-78M$-107M··
Profitability 7
Metric Trend 2025202420232022
Operating Margin -26.1%-72.7%-85.7%·
Net Margin -28.7%-74.5%-88.4%·
Pretax Margin -28.8%-74.5%-88.1%·
EBITDA Margin -26.1%-72.7%-85.7%·
ROA -29.1%-49.7%-52.0%-89.3%
ROE -227.0%-383.2%-103.9%-140.2%
ROIC -60.2%-118.1%-63.1%·
Liquidity & Solvency 5
Metric Trend 2025202420232022
Current Ratio 1.62.13.62.5
Quick Ratio 1.42.03.52.5
Debt / Equity 2.13.20.90.9
LT Debt / Equity 1.33.20.90.9
Interest Coverage 10.513.0··
Efficiency 3
Metric Trend 2025202420232022
Asset Turnover 1.00.70.60.0
Inventory Turnover ···2.4
Receivables Turnover 3.53.34.10.0
Per Share 5
Metric Trend 2025202420232022
Book Value / Share $1.74$1.17$4.03$2.52
Revenue / Share $12.83$8.05$5.96$0.00
Cash Flow / Share $-1.88$-2.68$-3.19$-2.87
Cash / Share $6.35$6.48$8.16$4.62
EPS (TTM) $-3.68$-5.99$-5.27$-4.60
Growth Rates 2
Metric Trend 2025202420232022
Revenue YoY 65.5%42.5%440.8%·
Revenue CAGR 3Y 133.7%···
Valuation (TTM) 14
Metric Trend 2025202420232022
Revenue TTM $638M$386M$271M$50M
Net Income TTM $-183M$-287M$-239M$-187M
Market Cap $9.29B$4.12B$3.77B$3.36B
Enterprise Value $9.16B$3.98B$3.56B$3.25B
P/E -49.6-14.1-15.1-16.8
P/S 14.610.713.967.1
P/B 105.372.219.730.6
P / Tangible Book 260.1·30.084.8
P / Cash Flow -99.5-32.1-26.0-28.8
P / FCF -99.0-32.0-25.9-28.6
EV / EBITDA -54.9-14.2-15.4-18.1
EV / FCF -97.5-31.0-24.4-27.7
EV / Revenue 14.310.313.264.9
Earnings Yield -2.0%-7.1%-6.6%-6.0%

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $638M $386M $271M $50M ·
Operating Margin % -26.1% -72.7% -85.7% · ·
Net Income $-183M $-287M $-239M $-187M $-130M
Diluted EPS $-3.68 $-5.99 $-5.27 $-4.60 $-3.47

Institutional owners (13F) 553 filers · $10.3B total · As of June 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 553
Value held $10.3B
New positions 145
Exited positions 33
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
145 (+63 vs prior Q) 33 (-19 vs prior Q) 165 (+20 vs prior Q) 164 (+19 vs prior Q) +2.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
VANGUARD GROUP INC $760,662,360 4,164,818 7.37% Shares
BlackRock, Inc. $759,694,607 3,103,708 7.36% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $485,504,722 1,983,514 4.71% Shares
VANGUARD CAPITAL MANAGEMENT LLC $480,994,100 1,965,086 4.66% Shares
Invesco Ltd. $409,178,095 1,671,684 3.97% Shares
FMR LLC $376,740,965 1,539,163 3.65% Shares
GEODE CAPITAL MANAGEMENT, LLC $236,786,194 967,172 2.29% Shares
MORGAN STANLEY $196,815,434 804,082 1.91% Shares
STATE STREET CORP $192,289,814 785,661 1.86% Shares
Deep Track Capital, LP $171,339,000 700,000 1.66% Shares
TWO SIGMA INVESTMENTS, LP $163,868,130 669,478 1.59% Shares
FRANKLIN RESOURCES INC $163,597,660 668,373 1.59% Shares
WELLINGTON MANAGEMENT GROUP LLP $160,059,998 653,920 1.55% Shares
ALETHEA CAPITAL MANAGEMENT, LLC $158,796,006 648,756 1.54% Shares
D. E. Shaw & Co., Inc. $148,025,392 604,753 1.43% Shares
MILLENNIUM MANAGEMENT LLC $136,113,660 556,088 1.32% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $132,031,000 539,407 1.28% Shares
NORGES BANK $125,876,889 514,266 1.22% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $118,811,358 485,400 1.15% Put option
FIRST TRUST ADVISORS LP $117,994,070 482,061 1.14% Shares
Assenagon Asset Management S.A. $111,292,513 454,682 1.08% Shares
BANK OF AMERICA CORP /DE/ $110,756,330 452,491 1.07% Shares
AMERIPRISE FINANCIAL INC $104,781,493 428,079 1.02% Shares
Pictet Asset Management Holding SA $104,399,930 426,527 1.01% Shares
Qube Research & Technologies Ltd $104,354,263 426,336 1.01% Shares
Point72 Asset Management, L.P. $101,950,621 416,516 0.99% Shares
JANE STREET GROUP, LLC $98,885,856 403,995 0.96% Shares
Hood River Capital Management LLC $98,563,494 402,678 0.96% Shares
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND $91,315,610 373,067 0.89% Shares
Driehaus Capital Management LLC $91,170,461 372,474 0.88% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $81,802,134 334,200 0.79% Call option
PRINCIPAL FINANCIAL GROUP INC $81,420,780 332,642 0.79% Shares
EVENTIDE ASSET MANAGEMENT, LLC $77,534,680 316,820 0.75% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $77,372,776 316,104 0.75% Shares
Integral Health Asset Management, LLC $73,431,000 300,000 0.71% Shares
VANGUARD FIDUCIARY TRUST CO $68,471,470 279,738 0.66% Shares
NORTHERN TRUST CORP $66,134,161 270,189 0.64% Shares
RENAISSANCE TECHNOLOGIES LLC $64,129,740 262,000 0.62% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $63,403,752 259,034 0.61% Shares
CITADEL ADVISORS LLC $62,631,258 255,878 0.61% Shares
FRONTIER CAPITAL MANAGEMENT CO LLC $62,240,116 254,280 0.60% Shares
SAMLYN CAPITAL, LLC $60,217,091 246,015 0.58% Shares
Clearbridge Investments, LLC $60,109,141 245,574 0.58% Shares
LOOMIS SAYLES & CO L P $58,619,967 239,490 0.57% Shares
BNP PARIBAS FINANCIAL MARKETS $56,530,611 230,954 0.55% Shares
GOLDMAN SACHS GROUP INC $56,215,836 229,668 0.54% Shares
CANADA PENSION PLAN INVESTMENT BOARD $55,171,158 225,400 0.53% Shares
MARSHALL WACE, LLP $54,678,192 223,386 0.53% Shares
PFM Health Sciences, LP $53,750,513 219,596 0.52% Shares
Tri Locum Partners LP $53,680,019 219,308 0.52% Shares

Show all 553 institutional owners →

Activists & 5%+ owners 1 position

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Antecip Capital LLC, Herriot Tabuteau, M.D. Dec. 4, 2015 · Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 14 insiders · 8 officers · 5 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Nick Pizzie Chief Financial Officer June 9, 2026 M 42,867 0 2 $-10,178,010
John Golubieski Chief Financial Officer Aug. 4, 2017 A · 0 0 $0
Mark L. Jacobson Chief Operating Officer Sept. 3, 2026 M 0 0 4 $-8,896,262
Ari Maizel Chief Commercial Officer April 22, 2026 M 0 0 2 $-2,751,450
Hunter R. Murdock General Counsel April 21, 2026 A 0 0 0 $0
David C Marek Chief Commercial Officer March 17, 2020 A · 0 0 $0
Constance Ames Vice President, Finance March 15, 2017 A 4,358 0 0 $0
Randall Kaye Chief Medical Officer Dec. 23, 2015 P 6,022 0 0 $0
Roger Jeffs Director June 11, 2026 S 58,367 0 2 $-141,655
Mark Coleman Director June 8, 2026 M 30,389 0 5 $-8,207,327
Susan Mahony Director June 8, 2026 M 829 0 2 $-145,017
Mark E Saad Director June 8, 2026 M 11,431 0 2 $-6,206,969
Myrtle S Potter Director June 7, 2019 A · 0 0 $0
Herriot Tabuteau · Aug. 6, 2026 M 7,229 0 17 $-103,220,752

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 54 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBRN · iShares Trust 3.57% 1,265 SH Sept. 11, 2026 Daily
PTH · Invesco Exchange-Traded Fund Trust 3.33% 66,274 SH Oct. 1, 2026 Daily
IHE · iShares Trust 2.08% 159,997 SH Sept. 11, 2026 Daily
FXH · First Trust Exchange-Traded AlphaDE… 2.02% 96,954 NS July 31, 2026 N-PORT
SAWS · ETF Series Solutions 1.33% 477 NS July 31, 2026 N-PORT
BBP · ETFis Series Trust I 1.18% 5,319 NS July 31, 2026 N-PORT
PILL · Direxion Shares ETF Trust 1.01% 953 NS July 31, 2026 N-PORT
FNY · First Trust Exchange-Traded AlphaDE… 0.71% 18,750 NS July 31, 2026 N-PORT
IBB · iShares Trust 0.67% 328,705 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.63% 3,702 SH Oct. 1, 2026 Daily
ESSC · Strategy Shares 0.59% 968 NS July 31, 2026 N-PORT
PDP · Invesco Exchange-Traded Fund Trust 0.52% 41,831 SH Oct. 1, 2026 Daily
MEDI · Harbor ETF Trust 0.49% 929 NS July 31, 2026 N-PORT
BRNY · EA Series Trust 0.47% 12,533 NS July 31, 2026 N-PORT
HQGO · Lattice Strategies Trust 0.35% 791 NS July 31, 2026 N-PORT
FNX · First Trust Exchange-Traded AlphaDE… 0.33% 21,040 NS July 31, 2026 N-PORT
ISCG · iShares Trust 0.29% 13,340 SH Sept. 11, 2026 Daily
VBK · VANGUARD INDEX FUNDS 0.29% 579,303 SH Aug. 19, 2026 Daily
IWP · iShares Trust 0.27% 242,834 SH Sept. 11, 2026 Daily
FAD · First Trust Exchange-Traded AlphaDE… 0.21% 5,628 NS July 31, 2026 N-PORT
BKMC · BNY Mellon ETF Trust 0.21% 6,280 NS July 31, 2026 N-PORT
FFSM · FIDELITY COVINGTON TRUST 0.20% 13,969 NS July 31, 2026 N-PORT
BBMC · J.P. Morgan Exchange-Traded Fund Tr… 0.20% 18,416 NS July 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.18% 14,304 SH Aug. 19, 2026 Daily
JMOM · J.P. Morgan Exchange-Traded Fund Tr… 0.16% 18,891 NS July 31, 2026 N-PORT
IYH · iShares Trust 0.15% 25,159 SH Sept. 11, 2026 Daily
VHT · VANGUARD WORLD FUND 0.14% 119,127 SH Aug. 19, 2026 Daily
FTLS · First Trust Exchange-Traded Fund III 0.13% 15,434 NS July 31, 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0.13% 1,003,143 SH Aug. 19, 2026 Daily
SMMD · iShares Trust 0.13% 23,029 SH Sept. 11, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.12% 18,841 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.12% 495,949 SH Aug. 19, 2026 Daily
ESML · iShares Trust 0.11% 14,935 SH Sept. 11, 2026 Daily
VFQY · VANGUARD WELLINGTON FUND 0.10% 1,871 SH Aug. 19, 2026 Daily
LRGF · iShares Trust 0.09% 16,402 SH Sept. 11, 2026 Daily
EQAL · Invesco Exchange-Traded Fund Trust … 0.08% 3,574 SH Oct. 1, 2026 Daily
ROUS · Lattice Strategies Trust 0.08% 2,668 NS July 31, 2026 N-PORT
WSML · iShares Trust 0.08% 2,447 SH Sept. 11, 2026 Daily
IWR · iShares Trust 0.07% 176,442 SH Sept. 11, 2026 Daily
VONG · VANGUARD SCOTTSDALE FUNDS 0.03% 68,223 SH Aug. 19, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.03% 4,316 SH Oct. 1, 2026 Daily
IWF · iShares Trust 0.03% 162,044 SH Sept. 11, 2026 Daily
VONE · VANGUARD SCOTTSDALE FUNDS 0.02% 7,087 SH Aug. 19, 2026 Daily
ESGV · VANGUARD WORLD FUND 0.02% 9,758 SH Aug. 19, 2026 Daily
TILT · FlexShares Trust 0.02% 1,880 NS July 31, 2026 N-PORT
IWB · iShares Trust 0.01% 29,751 SH Sept. 11, 2026 Daily
ITOT · iShares Trust 0.01% 56,291 SH Sept. 11, 2026 Daily
IWV · iShares Trust 0.01% 11,455 SH Sept. 11, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.01% 1,389,011 SH Aug. 19, 2026 Daily
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0.01% 35,579 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 3,636 SH Aug. 19, 2026 Daily
ISCB · iShares Trust · 1,888 SH Sept. 11, 2026 Daily
SMLF · iShares Trust · 83,383 SH Sept. 11, 2026 Daily
SMMV · iShares Trust · 3,403 SH Aug. 19, 2026 Daily

AXSM Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 28 analysts BUY
Median target $278.00 +55.1%
10 35.7% Strong Buy
16 57.1% Buy
2 7.1% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

22 analysts · 2026-10-02

Mean target $284.63 +58.8%

← Below all targets Current price $179.25
Low$246.00 Mean$284.63 High$380.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
AXSM $9.29B -49.6 65.5% -28.7% -227.0% ·
VTRS · -4.2 -3.0% -24.6% -23.2% 35.1%
CORT $3.69B 42.4 12.8% 13.1% 15.5% ·
ELAN $11.25B -48.1 6.2% -4.9% -3.5% 55.0%
BLTE $6.29B -69.2 · · -16.9% ·
AMRX · 57.3 8.1% 2.4% -80.0% 36.9%
LGND $3.74B 30.8 60.4% 46.4% 13.5% ·
DFTX $1.32B -6.5 212.0% · -71.0% ·
LLY · 46.8 44.7% 31.7% 101.2% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Aug 10, 2026