QTTB — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $52,590,554 | 4,127,987 | 18.53% | Shares |
| Boxer Capital Management, LLC | $40,122,209 | 3,149,310 | 14.14% | Shares |
| Atlas Venture Life Science Advisors, LLC | $34,615,930 | 2,717,106 | 12.20% | Shares |
| BVF INC/IL | $29,939,000 | 2,350,000 | 10.55% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $29,715,502 | 2,332,457 | 10.47% | Shares |
| Point72 Asset Management, L.P. | $14,949,065 | 1,173,396 | 5.27% | Shares |
| Opaleye Management Inc. | $11,860,940 | 931,000 | 4.18% | Shares |
| Logos Global Management LP | $10,192,000 | 800,000 | 3.59% | Shares |
| SummitTX Capital, L.P. | $9,348,281 | 733,774 | 3.29% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $6,609,550 | 518,803 | 2.33% | Shares |
| Ikarian Capital, LLC | $5,478,200 | 430,000 | 1.93% | Shares |
| Woodline Partners LP | $3,646,341 | 286,212 | 1.29% | Shares |
| AMERICAN CENTURY COMPANIES INC | $3,474,860 | 272,752 | 1.22% | Shares |
| Sanofi | $3,109,617 | 244,083 | 1.10% | Shares |
| ACORN CAPITAL ADVISORS, LLC | $2,754,019 | 216,171 | 0.97% | Shares |
| Ikarian Capital, LLC | $2,548,000 | 200,000 | 0.90% | Put option |
| RENAISSANCE TECHNOLOGIES LLC | $2,288,104 | 179,600 | 0.81% | Shares |
| JANE STREET GROUP, LLC | $2,073,396 | 162,747 | 0.73% | Shares |
| MONIMUS CAPITAL MANAGEMENT, LP | $1,682,139 | 132,036 | 0.59% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $1,661,640 | 130,427 | 0.59% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $1,563,506 | 122,690 | 0.55% | Shares |
| CITADEL ADVISORS LLC | $1,537,247 | 120,663 | 0.54% | Shares |
| BlackRock, Inc. | $1,509,780 | 118,507 | 0.53% | Shares |
| VANGUARD GROUP INC | $1,065,889 | 321,051 | 0.38% | Shares |
| MARSHALL WACE, LLP | $854,153 | 67,045 | 0.30% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $843,605 | 66,217 | 0.30% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $780,962 | 61,300 | 0.28% | Put option |
| Carlyle Group Inc. | $769,020 | 60,363 | 0.27% | Shares |
| STATE STREET CORP | $665,206 | 52,214 | 0.23% | Shares |
| TWO SIGMA INVESTMENTS, LP | $631,675 | 49,582 | 0.22% | Shares |
| Quadrature Capital Ltd | $463,685 | 36,396 | 0.16% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $440,970 | 34,613 | 0.16% | Shares |
| DAFNA Capital Management LLC | $419,095 | 32,896 | 0.15% | Shares |
| Knott David M Jr | $387,449 | 30,412 | 0.14% | Shares |
| Affinity Asset Advisors, LLC | $353,879 | 27,777 | 0.12% | Shares |
| Squarepoint Ops LLC | $303,085 | 23,790 | 0.11% | Shares |
| NORTHERN TRUST CORP | $301,059 | 23,631 | 0.11% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $300,511 | 23,588 | 0.11% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $297,377 | 23,342 | 0.10% | Shares |
| MANGROVE PARTNERS IM, LLC | $282,191 | 22,150 | 0.10% | Shares |
| LPL Financial LLC | $231,486 | 18,170 | 0.08% | Shares |
| UBS Group AG | $191,202 | 15,008 | 0.07% | Shares |
| Balyasny Asset Management L.P. | $157,237 | 12,342 | 0.06% | Shares |
| ExodusPoint Capital Management, LP | $144,421 | 11,336 | 0.05% | Shares |
| MILLENNIUM MANAGEMENT LLC | $139,223 | 10,928 | 0.05% | Shares |
| XTX Topco Ltd | $138,535 | 10,874 | 0.05% | Shares |
| MORGAN STANLEY | $82,259 | 6,456 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $61,458 | 4,824 | 0.02% | Shares |
| FMR LLC | $43,163 | 3,388 | 0.02% | Shares |
| CITIGROUP INC | $36,793 | 2,888 | 0.01% | Shares |
| Private Wealth Asset Management, LLC | $21,658 | 1,700 | 0.01% | Shares |
| Arax Advisory Partners | $14,154 | 1,111 | 0.00% | Shares |
| FEDERATED HERMES, INC. | $13,377 | 1,050 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $7,351 | 577 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $6,585 | 500 | 0.00% | Shares |
| Russell Investments Group, Ltd. | $5,784 | 454 | 0.00% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $3,860 | 303 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $3,058 | 240 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $2,779 | 218,234 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $2,115 | 166 | 0.00% | Shares |
| Truvestments Capital LLC | $2,064 | 162 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $1,579 | 124 | 0.00% | Shares |
| Allworth Financial LP | $1,376 | 108 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $1,198 | 94 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $888 | 70 | 0.00% | Shares |
| Clearstead Advisors, LLC | $854 | 67 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $573 | 45 | 0.00% | Shares |
| GROUP ONE TRADING LLC | $433 | 34 | 0.00% | Shares |
| CWM, LLC | $250 | 39 | 0.00% | Shares |
| Cambridge Investment Research Advisors, Inc. | $230 | 18,081 | 0.00% | Shares |
| HRT FINANCIAL LP | $203 | 15,949 | 0.00% | Shares |
| HARBOUR INVESTMENTS, INC. | $140 | 11 | 0.00% | Shares |
| AdvisorNet Financial, Inc | $25 | 2 | 0.00% | Shares |
| DANSKE BANK A/S | $13 | 1 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $0 | 43 | 0.00% | Shares |