STOK Stoke Therapeutics, Inc. - Common Stock
NASDAQ · Biotechnology · View on SEC EDGAR ↗ close Oct 2, 2026 10-K/10-Q Aug 3, 2026
$25.62
· of 52w range
· above low
· to high
$20.3252w low
$40.2252w high
Market Cap (MRQ)
$1.60B
P/E (TTM)
-7.7
EPS (TTM)
$-3.34
Revenue (TTM)
$28M
your badges
52W Range
$20–$40
Analyst Rating
BUY
Price Target
$46
P/E
-7.7
ROE
-61.1%
Net Profit Margin
-753.6%
Your badge strip is empty — pin a metric anywhere on this page.
STOK Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$25.62
Market Cap (MRQ)
$1.60B
P/E (TTM)
-7.7
EPS (TTM)
$-3.34
Revenue (TTM)
$28M
ROE (TTM)
-61.1%
52W Range
$20–$40
STOK Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
range
bars
Bar granularity adapts to the selected period — hover the chart to see open/high/low/close for a bar.
10-Year Performance Revenue, net income, margins and EPS trends
Revenue$184M2022-12-31 → 2025-12-31
EPS$-0.122021-12-31 → 2025-12-31
Free Cash Flow$45M2019-12-31 → 2025-12-31
Net margin-753.6%2022-12-31 → 2025-12-31
Valuation & Ratios
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
| Metric | 5Y trend | STOK | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| P/E (TTM) | -7.75Y avg ≈-57.4 | ≈-57.4 | · | · | |
| P/S (TTM) | 58.05Y avg ≈20.8 | ≈20.8 | 25.6 | Overvalued | |
| P/B (MRQ) | 4.65Y avg ≈3.1 | ≈3.1 | 5.7 | Overvalued | |
| Price / FCF (TTM) | -8.85Y avg ≈1.7 | ≈1.7 | · | · | |
| Price / Cash Flow (TTM) | -9.05Y avg ≈1.3 | ≈1.3 | · | · | |
| Price / Tangible Book | 4.35Y avg ≈3.1 | ≈3.1 | · | · |
Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.
Profitability Gross, operating and net margins; ROE, ROA, ROIC
| Metric | 5Y trend | STOK | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| Operating Margin (TTM) | -809.7%5Y avg ≈-609.2% | ≈-609.2% | -701.6% | In line | |
| EBITDA Margin | -11.2%5Y avg ≈-609.2% | ≈-609.2% | -701.6% | In line | |
| Net Profit Margin (TTM) | -753.6%5Y avg ≈-563.6% | ≈-563.6% | -660.8% | In line | |
| ROA (TTM) | -53.4%5Y avg ≈-30.7% | ≈-30.7% | -29.0% | Top tier | |
| ROE (TTM) | -61.1%5Y avg ≈-38.6% | ≈-38.6% | -51.7% | Top tier |
Financial Health Debt, liquidity, solvency — balance sheet strength
| Metric | 5Y trend | STOK | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| Current Ratio (MRQ) | 7.75Y avg ≈7.8 | ≈7.8 | 6.6 | Strong liquidity | |
| Quick Ratio | 1.65Y avg ≈4.6 | ≈4.6 | 3.9 | Low liquidity | |
| Interest Coverage | -2287.8 | · | -39.3 | Low liquidity |
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
| Metric | 5Y trend | STOK | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| Revenue YoY | 404.5%5Y avg ≈230.5% | ≈230.5% | · | · | |
| Revenue CAGR 3Y | 145.9% | · | · | · |
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
| Metric | 5Y trend | STOK | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| Asset Turnover | 0.55Y avg ≈0.2 | ≈0.2 | 0.3 | Top tier | |
| Receivables Turnover | 48.5 | · | 6.2 | Top tier | |
| Revenue / Employee | ≈$1.1M | · | · | · |
value · ≈ 5Y avg · industry median · verdict relative to median
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
85.0%
Next Report
Nov 02, 2026
| Period | Report | EPS Actual | EPS Est | Surprise |
|---|---|---|---|---|
| June 30, 2026 | Aug 10, 2026 | $-0.93 | $-0.81 | -14.6% |
| March 31, 2026 | May 11, 2026 | $-0.79 | $-0.84 | 6.3% |
| Dec. 31, 2025 | $-0.97 | $-0.73 | -33.3% | |
| Sept. 30, 2025 | $-0.65 | $-0.58 | -12.1% | |
| June 30, 2025 | $-0.40 | $-0.52 | 23.4% | |
| March 31, 2025 | $1.98 | $-0.43 | 558.7% | |
| Dec. 31, 2024 | $-0.18 | $-0.54 | 66.6% |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue | $184M | $37M | $9M | $12M | |
| R&D Expense | $138M | $89M | $82M | $78M | |
| SG&A Expense | $67M | $49M | $41M | $39M | |
| Operating Expenses | $205M | $138M | $124M | $117M | |
| Operating Income | $-21M | $-101M | $-115M | $-104M | |
| Interest Expense | $9.0K | $26.0K | $49.0K | · | |
| Interest Income | $14M | $13M | $10M | · | |
| Other Non-op | $-51.0K | $-247.0K | $166.0K | $167.0K | |
| Income Tax | $0 | · | · | · | |
| Net Income | $-7M | $-89M | $-105M | $-101M | |
| EPS (Basic) | $-0.12 | $-1.65 | $-2.38 | $-2.60 | |
| EPS (Diluted) | $-0.12 | $-1.65 | $-2.38 | $-2.60 | |
| Shares (Basic) | 59,219,184 | 54,008,883 | 43,994,862 | 38,897,442 | |
| Shares (Diluted) | 59,219,184 | 54,008,883 | 43,994,862 | 38,897,442 | |
| EBITDA | $-21M | $-101M | $-115M | $-104M |
Balance Sheet
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $84M | $128M | $191M | $114M | |
| Receivables | $6M | $2M | · | · | |
| Prepaid Expense | $9M | $11M | $11M | $11M | |
| Other Current Assets | $4M | $2M | $3M | $3M | |
| Current Assets | $306M | $233M | $215M | $244M | |
| PP&E (Net) | $3M | $4M | $6M | $7M | |
| PP&E (Gross) | $13M | $13M | $12M | $11M | |
| Accum. Depreciation | $10M | $9M | $7M | $4M | |
| Total Assets | $418M | $272M | $228M | $256M | |
| Accounts Payable | $5M | $2M | $2M | $766.0K | |
| Current Liabilities | $58M | $40M | $31M | $31M | |
| Capital Leases | $1M | $2M | $5M | $3M | |
| Other Non-current Liabilities | $1M | $2M | $5M | $3M | |
| Total Liabilities | $66M | $43M | $69M | $71M | |
| Common Stock | $5.0K | $5.0K | $5.0K | $4.0K | |
| Paid-in Capital | $850M | $720M | $561M | $483M | |
| Retained Earnings | $-498M | $-491M | $-402M | $-297M | |
| AOCI | $543.0K | $-151.0K | $-24.0K | $-1M | |
| Stockholders' Equity | $352M | $229M | $160M | $185M | |
| Liabilities + Equity | $418M | $272M | $228M | $256M | |
| Shares Outstanding | 58,921,999 | 54,032,826 | 45,918,233 | 39,439,575 |
Cash Flow
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Stock-based Comp | $32M | $27M | $25M | $23M | |
| Operating Cash Flow | $46M | $-87M | $-81M | $-32M | |
| CapEx | $670.0K | $203.0K | $2M | $4M | |
| Investing Cash Flow | $-187M | $-107M | $106M | $-46M | |
| Financing Cash Flow | $97M | $131M | $53M | $46M | |
| Net Change in Cash | $-44M | $-63M | $78M | $-31M | |
| Taxes Paid | $573.0K | · | · | · | |
| Free Cash Flow | $45M | $-87M | $-83M | $-36M |
Profitability
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Operating Margin | -11.2% | -277.3% | -1307.2% | -841.2% | |
| Net Margin | -3.7% | -243.4% | -1192.5% | -814.7% | |
| EBITDA Margin | -11.2% | -277.3% | -1307.2% | -841.2% | |
| ROA | -2.0% | -35.6% | -43.2% | -40.8% | |
| ROE | -2.0% | -38.6% | -63.0% | -52.0% |
Liquidity & Solvency
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 5.3 | 5.8 | 7.0 | 7.8 | |
| Quick Ratio | 1.6 | 3.2 | 6.2 | 3.6 | |
| Interest Coverage | -2287.8 | -3898.9 | · | · |
Efficiency
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Asset Turnover | 0.5 | 0.1 | 0.0 | 0.1 | |
| Receivables Turnover | 48.5 | · | · | · |
Per Share
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Book Value / Share | $5.98 | $4.24 | $3.48 | $4.69 | |
| Revenue / Share | $3.11 | $0.68 | $0.20 | $0.32 | |
| Cash Flow / Share | $0.77 | $-1.61 | $-1.84 | $-0.82 | |
| Cash / Share | $1.43 | $2.37 | $4.17 | $2.88 | |
| EPS (TTM) | $-0.12 | $-1.65 | $-2.38 | $-2.60 |
Growth Rates
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue YoY | 404.5% | 316.3% | -29.2% | · | |
| Revenue CAGR 3Y | 145.9% | · | · | · |
Valuation (TTM)
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue TTM | $184M | $37M | $9M | $12M | |
| Net Income TTM | $-7M | $-89M | $-105M | $-101M | |
| Market Cap | $1.87B | $596M | $242M | $364M | |
| P/E | -264.5 | -6.7 | -2.2 | -3.5 | |
| P/S | 10.1 | 16.3 | 27.5 | 29.3 | |
| P/B | 5.3 | 2.6 | 1.5 | 2.0 | |
| P / Tangible Book | 5.3 | 2.6 | 1.5 | 2.0 | |
| P / Cash Flow | 41.0 | -6.9 | -3.0 | -11.4 | |
| P / FCF | 41.6 | -6.8 | -2.9 | -10.2 | |
| Earnings Yield | -0.38% | -15.0% | -45.2% | -28.2% |
Income Statement
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $9M | $6M | $1M | $11M | $14M | $159M | $23M | $5M | $5M | $4M | $3M | $3M | $-2M | $5M | $3M | $3M | |
| R&D Expense | $50M | $40M | $42M | $38M | $26M | $33M | $23M | $22M | $21M | $22M | $22M | $20M | $21M | $20M | $21M | $20M | |
| SG&A Expense | $25M | $20M | $21M | $16M | $15M | $15M | $13M | $13M | $13M | $10M | $11M | $10M | $10M | $10M | $9M | $10M | |
| Operating Expenses | $75M | $60M | $63M | $54M | $41M | $47M | $36M | $35M | $34M | $33M | $32M | $31M | $31M | $30M | $30M | $30M | |
| Operating Income | $-65M | $-53M | $-61M | $-43M | $-27M | $111M | $-14M | $-30M | $-29M | $-28M | $-30M | $-27M | $-33M | $-25M | $-27M | $-27M | |
| Interest Expense | $17.0K | $23.0K | $2.0K | $3.0K | $3.0K | $1.0K | $-1.0K | $0 | $5.0K | $22.0K | · | · | · | · | · | · | |
| Interest Income | $4M | $3M | $4M | $3M | $4M | $3M | $3M | $4M | $4M | $2M | · | · | · | · | · | · | |
| Other Non-op | $308.0K | $18.0K | $-110.0K | $3.0K | $28.0K | $28.0K | $201.0K | $28.0K | $-48.0K | $-428.0K | $42.0K | $41.0K | $41.0K | $42.0K | $41.0K | $42.0K | |
| Pretax Income | $-62M | $-50M | · | $-40M | $-23M | $114M | · | $-26M | $-26M | $-26M | · | · | · | · | · | · | |
| Income Tax | $0 | $0 | $0 | $-1M | $0 | $1M | · | $0 | $0 | $0 | · | $0 | $0 | $0 | · | $0 | |
| Net Income | $-62M | $-50M | $-58M | $-38M | $-23M | $113M | $-10M | $-26M | $-26M | $-26M | $-27M | $-25M | $-31M | $-23M | $-26M | $-26M | |
| EPS (Basic) | $-0.93 | $-0.79 | $-1.02 | $-0.65 | $-0.40 | $1.95 | $-0.15 | $-0.47 | $-0.46 | $-0.57 | $-0.61 | $-0.55 | $-0.69 | $-0.53 | $-0.65 | $-0.66 | |
| EPS (Diluted) | $-0.93 | $-0.79 | $-0.97 | $-0.65 | $-0.40 | $1.90 | $-0.15 | $-0.47 | $-0.46 | $-0.57 | $-0.61 | $-0.55 | $-0.69 | $-0.53 | $-0.65 | $-0.66 | |
| Shares (Basic) | 66,017,895 | 63,063,507 | · | 58,611,677 | 58,353,855 | 57,862,674 | · | 56,341,074 | 55,765,948 | 46,246,889 | · | 44,266,017 | 44,188,464 | 42,536,474 | · | 39,420,310 | |
| Shares (Diluted) | 66,017,895 | 63,063,507 | · | 58,611,677 | 58,353,855 | 59,398,600 | · | 56,341,074 | 55,765,948 | 46,246,889 | · | 44,266,017 | 44,188,464 | 42,536,474 | · | 39,420,310 | |
| EBITDA | $-65M | $-53M | · | $-43M | $-27M | $111M | · | $-30M | $-29M | $-28M | · | $-27M | $-33M | $-25M | · | $-27M |
Balance Sheet
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $110M | $156M | $84M | $83M | $101M | $275M | $128M | $150M | $193M | $179M | $191M | $190M | $192M | $190M | $114M | $113M | |
| Receivables | $7M | $4M | $6M | $9M | · | · | $2M | · | · | · | · | · | · | · | · | · | |
| Prepaid Expense | $15M | $10M | $9M | $8M | $14M | $13M | $11M | $10M | $10M | $11M | $11M | $11M | $11M | $10M | $11M | $13M | |
| Other Current Assets | $6M | $7M | $4M | $6M | $7M | $5M | $2M | $4M | $4M | $4M | $3M | $4M | $4M | $6M | $3M | · | |
| Current Assets | $323M | $367M | $306M | $272M | $270M | $376M | $233M | $254M | $297M | $193M | $215M | $230M | $246M | $270M | $244M | $265M | |
| PP&E (Net) | $5M | $3M | $3M | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $6M | $6M | $6M | $7M | $7M | $7M | |
| PP&E (Gross) | · | · | $13M | · | · | · | $13M | · | · | · | $12M | · | · | · | $11M | · | |
| Accum. Depreciation | · | · | $10M | · | · | · | $9M | · | · | · | $7M | · | · | · | $4M | · | |
| Total Assets | $394M | $443M | $418M | $360M | $385M | $407M | $272M | $293M | $308M | $205M | $228M | $240M | $257M | $282M | $256M | $278M | |
| Accounts Payable | $5M | $7M | $5M | $6M | $4M | $2M | $2M | $2M | $4M | $2M | $2M | $3M | $2M | $4M | $766.0K | $2M | |
| Current Liabilities | $42M | $41M | $58M | $42M | $39M | $45M | $40M | $50M | $44M | $36M | $31M | $25M | $22M | $32M | $31M | $29M | |
| Capital Leases | $837.0K | $990.0K | $1M | $2M | $1M | $2M | $2M | $3M | $4M | $4M | $5M | $819.0K | $1M | $2M | $3M | $3M | |
| Other Non-current Liabilities | $837.0K | $991.0K | $1M | $2M | $1M | $2M | $2M | $3M | $4M | $4M | $5M | $959.0K | $2M | $2M | $3M | $4M | |
| Total Liabilities | $48M | $48M | $66M | $52M | $50M | $57M | $43M | $61M | $65M | $65M | $69M | $67M | $67M | $68M | $71M | $73M | |
| Common Stock | $6.0K | $6.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | |
| Paid-in Capital | $955M | $943M | $850M | $747M | $736M | $728M | $720M | $712M | $697M | $569M | $561M | $548M | $541M | $534M | $483M | $477M | |
| Retained Earnings | $-609M | $-548M | $-498M | $-440M | $-401M | $-378M | $-491M | $-480M | $-454M | $-428M | $-402M | $-375M | $-350M | $-320M | $-297M | $-271M | |
| AOCI | $-542.0K | $-115.0K | $543.0K | $446.0K | $96.0K | $-104.0K | $-151.0K | $166.0K | $-15.0K | · | $-24.0K | $-147.0K | $-379.0K | $-598.0K | $-1M | $-2M | |
| Stockholders' Equity | $346M | $395M | $352M | $308M | $335M | $350M | $229M | $232M | $243M | $140M | $160M | $173M | $190M | $214M | $185M | $204M | |
| Liabilities + Equity | $394M | $443M | $418M | $360M | $385M | $407M | $272M | $293M | $308M | $205M | $228M | $240M | $257M | $282M | $256M | $278M | |
| Shares Outstanding | 62,402,595 | 62,240,347 | 58,921,999 | 55,120,002 | 54,723,455 | 54,595,714 | 54,032,826 | 52,941,191 | 52,305,641 | 46,498,077 | 45,918,233 | 44,293,115 | 44,202,997 | 44,175,089 | 39,439,575 | 39,426,440 |
Cash Flow
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $11M | $9M | $10M | $8M | $8M | $7M | $7M | $7M | $7M | $5M | $6M | $7M | $7M | $6M | $6M | $6M | |
| Operating Cash Flow | $-57M | $-61M | $-30M | $-30M | $-25M | $132M | $-23M | $-22M | $-17M | $-25M | $-21M | $-17M | $-22M | $-21M | $-22M | $-22M | |
| CapEx | $2M | $353.0K | $232.0K | $132.0K | $154.0K | $152.0K | $42.0K | $103.0K | $46.0K | $12.0K | $229.0K | $383.0K | $839.0K | $165.0K | $409.0K | $2M | |
| Investing Cash Flow | $9M | $51M | $-61M | $9M | $-148M | $14M | $819.0K | $-30M | $-88M | $10M | $15M | $15M | $23M | $53M | $22M | $67M | |
| Financing Cash Flow | $2M | $84M | $92M | $3M | $554.0K | $1M | $568.0K | $8M | $121M | $2M | $7M | $562.0K | $48.0K | $45M | $43.0K | $434.0K | |
| Net Change in Cash | $-46M | $74M | $826.0K | $-18M | $-173M | $147M | $-22M | $-43M | $15M | $-13M | $1M | $-2M | $2M | $77M | $160.0K | $46M | |
| Free Cash Flow | · | $-61M | · | · | · | $132M | · | · | · | $-25M | · | · | · | $-22M | · | · | |
| Levered FCF | · | $-61M | · | · | · | $132M | · | · | · | · | · | · | · | · | · | · |
Profitability
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -701.6% | -857.6% | · | -405.3% | -197.6% | 70.2% | · | -613.1% | -607.4% | -673.0% | · | -823.3% | 1340.7% | -479.2% | · | -934.5% | |
| Net Margin | -660.8% | -802.8% | · | -360.7% | -170.0% | 71.2% | · | -540.0% | -531.9% | -625.6% | · | -741.9% | 1235.5% | -437.6% | · | -898.8% | |
| Pretax Margin | -660.8% | -802.8% | · | -372.7% | -170.0% | 72.0% | · | · | · | · | · | · | · | · | · | · | |
| EBITDA Margin | -701.6% | -857.6% | · | -405.3% | -197.6% | 70.2% | · | -613.1% | -607.4% | -673.0% | · | -823.3% | 1340.7% | -479.2% | · | -934.5% | |
| ROA | -15.8% | -11.8% | · | -11.7% | -6.8% | 36.9% | · | -9.9% | -9.1% | -10.8% | · | -9.5% | -11.0% | -7.5% | · | -9.8% | |
| ROE | -18.1% | -13.4% | · | -14.2% | -8.1% | 46.0% | · | -13.1% | -11.9% | -14.9% | · | -13.0% | -14.8% | -9.9% | · | -11.8% | |
| ROIC | -18.9% | -13.5% | · | -13.5% | -8.2% | 31.4% | · | · | · | · | · | · | · | · | · | · |
Liquidity & Solvency
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 7.7 | 9.0 | · | 6.5 | 7.0 | 8.4 | · | 5.1 | 6.7 | 5.4 | · | 9.1 | 11.3 | 8.6 | · | 9.2 | |
| Quick Ratio | 2.8 | 3.9 | · | 2.2 | 2.6 | 6.2 | · | 3.0 | 4.3 | 5.0 | · | 7.5 | 8.8 | 6.0 | · | 3.9 | |
| Interest Coverage | -3848.8 | -2322.5 | · | -14363.7 | -9100.0 | 111240.0 | · | · | · | · | · | · | · | · | · | · |
Efficiency
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.5 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | -0.0 | 0.0 | · | 0.0 | |
| Receivables Turnover | 2.6 | 2.8 | · | 2.3 | · | · | · | · | · | · | · | · | · | · | · | · |
Per Share
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Book Value / Share | $5.54 | $6.34 | · | $5.59 | $6.12 | $6.41 | · | $4.38 | $4.64 | $3.02 | · | $3.91 | $4.30 | $4.84 | · | $5.18 | |
| Revenue / Share | $0.14 | $0.10 | · | $0.18 | $0.24 | $2.67 | · | $0.09 | $0.09 | $0.09 | · | $0.07 | $-0.06 | $0.12 | · | $0.07 | |
| Cash Flow / Share | · | $-0.96 | · | · | · | $2.22 | · | · | · | $-0.53 | · | · | · | $-0.50 | · | · | |
| Cash / Share | $1.76 | $2.50 | · | $1.51 | $1.85 | $5.03 | · | $2.83 | $3.70 | $3.84 | · | $4.29 | $4.34 | $4.31 | · | $2.88 | |
| EPS (TTM) | $-3.34 | $-2.81 | · | $0.70 | $0.88 | $0.82 | · | $-2.11 | $-2.19 | $-2.42 | · | $-2.42 | $-2.53 | $-2.47 | · | $-3.23 |
Valuation (TTM)
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $28M | $32M | · | $206M | $200M | $191M | · | $17M | $15M | $8M | · | $9M | $9M | $15M | · | · | |
| Net Income TTM | $-208M | $-170M | · | $41M | $52M | $50M | · | $-105M | $-104M | $-109M | · | $-103M | $-105M | $-99M | · | $-100M | |
| Market Cap | $2.04B | $2.03B | · | $1.30B | $621M | $363M | · | $651M | $707M | $628M | · | $175M | $470M | $368M | · | $506M | |
| P/E | -9.8 | -11.6 | · | 33.6 | 12.9 | 8.1 | · | -5.8 | -6.2 | -5.6 | · | -1.6 | -4.2 | -3.4 | · | -4.0 | |
| P/S | 74.0 | 63.2 | · | 6.3 | 3.1 | 1.9 | · | 38.9 | 46.6 | 80.0 | · | 18.9 | 53.1 | 25.3 | · | · | |
| P/B | 5.9 | 5.1 | · | 4.2 | 1.9 | 1.0 | · | 2.8 | 2.9 | 4.5 | · | 1.0 | 2.5 | 1.7 | · | 2.5 | |
| P / Tangible Book | 5.9 | 5.1 | · | 4.2 | 1.9 | 1.0 | · | 2.8 | 2.9 | 4.5 | · | 1.0 | 2.5 | 1.7 | · | 2.5 | |
| P / Cash Flow | · | -33.5 | · | · | · | 2.8 | · | · | · | -25.6 | · | · | · | -17.2 | · | · | |
| Earnings Yield | -10.2% | -8.6% | · | 3.0% | 7.8% | 12.3% | · | -17.2% | -16.2% | -17.9% | · | -61.4% | -23.8% | -29.6% | · | -25.2% |
Most recent period on the left · null values shown as ·
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Revenue | $184M | $37M | $9M | $12M | · |
| Operating Margin % | -11.2% | -277.3% | -1307.2% | -841.2% | · |
| Net Income | $-7M | $-89M | $-105M | $-101M | $-86M |
| Diluted EPS | $-0.12 | $-1.65 | $-2.38 | $-2.60 | $-2.34 |
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Current Ratio | 5.3 | 5.8 | 7.0 | 7.8 | 13.4 |
| Quick Ratio | 1.6 | 3.2 | 6.2 | 3.6 | 8.5 |
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Free Cash Flow | $45M | $-87M | $-83M | $-36M | $-68M |
Institutional owners (13F) 202 filers · $2.5B total · As of Sept. 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Holders
202
Value held
$2.5B
New positions
29
Exited positions
26
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 29 (-17 vs prior Q) | 26 (0 vs prior Q) | 73 (-8 vs prior Q) | 58 (+6 vs prior Q) | +3.1M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| BlackRock, Inc. | $192,307,120 | 5,877,357 | 7.77% | Shares |
| RTW INVESTMENTS, LP | $184,001,738 | 5,623,525 | 7.44% | Shares |
| FMR LLC | $173,844,632 | 5,313,100 | 7.03% | Shares |
| Lynx1 Capital Management LP | $132,136,579 | 4,038,404 | 5.34% | Shares |
| Redmile Group, LLC | $129,110,502 | 3,945,920 | 5.22% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $115,151,528 | 3,519,301 | 4.65% | Shares |
| MORGAN STANLEY | $112,975,453 | 3,452,795 | 4.57% | Shares |
| BAKER BROS. ADVISORS LP | $109,176,726 | 3,336,697 | 4.41% | Shares |
| TORONTO DOMINION BANK | $103,829,002 | 3,173,258 | 4.20% | Shares |
| VANGUARD GROUP INC | $99,956,846 | 3,149,239 | 4.04% | Shares |
| STATE STREET CORP | $93,325,293 | 2,852,240 | 3.77% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $84,644,579 | 2,586,937 | 3.42% | Shares |
| BVF INC/IL | $83,356,065 | 2,547,557 | 3.37% | Shares |
| Siren, L.L.C. | $65,287,754 | 1,995,347 | 2.64% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $59,664,920 | 1,823,500 | 2.41% | Shares |
| Skorpios Trust | $53,020,254 | 2,256,181 | 2.14% | Shares |
| JANUS HENDERSON GROUP PLC | $52,455,703 | 1,612,781 | 2.12% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $49,884,057 | 1,524,309 | 2.02% | Shares |
| Assenagon Asset Management S.A. | $36,920,855 | 1,128,388 | 1.49% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $33,173,608 | 1,013,911 | 1.34% | Shares |
| Polar Capital Holdings Plc | $27,279,188 | 833,716 | 1.10% | Shares |
| EcoR1 Capital, LLC | $24,049,200 | 735,000 | 0.97% | Shares |
| MPM BIOIMPACT LLC | $23,666,834 | 723,314 | 0.96% | Shares |
| Opaleye Management Inc. | $22,904,000 | 700,000 | 0.93% | Shares |
| GOLDMAN SACHS GROUP INC | $18,825,256 | 575,344 | 0.76% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $18,552,011 | 566,993 | 0.75% | Shares |
| BAILLIE GIFFORD & CO | $16,925,238 | 517,275 | 0.68% | Shares |
| NORTHERN TRUST CORP | $16,364,057 | 500,124 | 0.66% | Shares |
| Troluce Capital Advisors LLC | $16,242,732 | 496,416 | 0.66% | Shares |
| FIRST TRUST ADVISORS LP | $16,062,673 | 490,913 | 0.65% | Shares |
| CITADEL ADVISORS LLC | $16,009,929 | 489,301 | 0.65% | Shares |
| Candriam S.C.A. | $15,694,935 | 480,136 | 0.63% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $15,280,633 | 467,012 | 0.62% | Shares |
| Granahan Investment Management, LLC | $15,103,814 | 461,608 | 0.61% | Shares |
| Erste Asset Management GmbH | $13,875,261 | 428,381 | 0.56% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $13,169,898 | 402,503 | 0.53% | Shares |
| Parkman Healthcare Partners LLC | $11,630,095 | 355,443 | 0.47% | Shares |
| Artisan Partners Limited Partnership | $11,620,606 | 355,153 | 0.47% | Shares |
| JANE STREET GROUP, LLC | $10,853,257 | 331,701 | 0.44% | Shares |
| TANG CAPITAL MANAGEMENT LLC | $9,816,000 | 300,000 | 0.40% | Shares |
| MILLENNIUM MANAGEMENT LLC | $8,540,836 | 261,028 | 0.35% | Shares |
| BANK OF AMERICA CORP /DE/ | $8,497,646 | 259,708 | 0.34% | Shares |
| JPMORGAN CHASE & CO | $8,480,802 | 259,352 | 0.34% | Shares |
| UBS Group AG | $6,776,705 | 207,112 | 0.27% | Shares |
| Birchview Capital, LP | $5,827,759 | 178,110 | 0.24% | Shares |
| Bank of New York Mellon Corp | $5,375,002 | 164,273 | 0.22% | Shares |
| NORGES BANK | $5,339,904 | 163,200 | 0.22% | Shares |
| FRANKLIN RESOURCES INC | $4,790,044 | 146,395 | 0.19% | Shares |
| DAFNA Capital Management LLC | $4,282,230 | 130,875 | 0.17% | Shares |
| ExodusPoint Capital Management, LP | $4,242,475 | 129,660 | 0.17% | Shares |
Activists & 5%+ owners 4 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| Blue Horizon Enterprise Ltd, Ezbon International Ltd, Montrago Trustees Ltd, Skorpios Trust ×3 filings | Aug. 26, 2025 | 4.10% | Amendment | · | SEC |
| Blue Horizon Enterprise Ltd., Ezbon International Limited, Montrago Trustees Limited, Skorpios Trust ×4 filings | Dec. 27, 2024 | 13.00% | Amendment | · | SEC |
| ATP Life Science Ventures, L.P., formerly known as Apple Tree Partners IV, L.P., ATP III GP, Ltd., Seth L. Harrison | June 29, 2021 | · | Initial filing | · | SEC |
| Apple Tree Partners IV, L.P., ATP III GP, Ltd., Seth L. Harrison ×2 filings | Nov. 27, 2020 | · | Initial filing | · | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Company insiders 21 insiders · 9 officers · 12 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Ian F Smith | Chief Executive Officer | Feb. 17, 2026 A | · | 0 | 0 | $0 |
| Thomas Leggett | Chief Financial Officer | March 18, 2026 S | 10,172 | 0 | 5 | $-147,141 |
| Stephen J Tulipano | Former CFO | March 27, 2024 A | 20,746 | 0 | 0 | $0 |
| Jonathan Allan | GENERAL COUNSEL & CORP SEC | Oct. 2, 2026 S | 20,598 | 0 | 23 | $-1,574,350 |
| Barry Ticho | CHIEF MEDICAL OFFICER | Oct. 1, 2026 S | 19,059 | 0 | 30 | $-1,881,169 |
| Thomas Mccauley | Chief Scientific Officer | July 15, 2026 A | · | 0 | 0 | $0 |
| Jason Hoitt | Chief Patient Officer | March 18, 2026 S | 10,276 | 0 | 5 | $-119,308 |
| Huw M. Nash | Chief Business Officer | July 2, 2024 S | 0 | 0 | 0 | $0 |
| Gene Liau | EVP Research & Preclinical Dev | March 2, 2021 M | 21,351 | 0 | 0 | $0 |
| Alexander Cumbo | Director | Sept. 23, 2026 A | · | 0 | 0 | $0 |
| Edward M. Kaye MD | Director | Aug. 14, 2026 M | 124,557 | 0 | 16 | $-3,182,783 |
| Seth Loring Harrison | Director | July 16, 2026 G | 17,161,713 | 0 | 0 | $0 |
| Adrian R. Krainer | Director | June 3, 2026 A | 283,302 | 0 | 5 | $-3,902,665 |
| Jennifer Burstein | Director | June 3, 2026 A | · | 0 | 0 | $0 |
| Arthur Tzianabos | Director | June 3, 2026 A | 31,339 | 0 | 1 | $-174,200 |
| Julie Smith | Director | June 3, 2026 A | · | 0 | 0 | $0 |
| LEVIN ARTHUR A | Director | June 3, 2026 A | 4,237 | 0 | 1 | $-22,264 |
| Clare Kahn | Director | April 3, 2026 A | · | 0 | 0 | $0 |
| Garry E Menzel | Director | June 3, 2025 A | · | 0 | 0 | $0 |
| Samuel W. Hall | Director | Sept. 10, 2019 A | · | 0 | 0 | $0 |
| Robin A. Walker | · | July 7, 2020 S | 0 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
ETF ownership Held by 37 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| BBC · ETFis Series Trust I | 0.65% | 10,423 NS | July 31, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.31% | 53,472 NS | July 31, 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0.17% | 86,608 NS | July 31, 2026 | N-PORT |
| VFMO · VANGUARD WELLINGTON FUND | 0.12% | 75,065 SH | Aug. 19, 2026 | Daily |
| FYC · First Trust Exchange-Traded AlphaDE… | 0.12% | 52,624 NS | July 31, 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.11% | 4,567 SH | Oct. 2, 2026 | Daily |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.11% | 59,041 SH | Aug. 19, 2026 | Daily |
| IBB · iShares Trust | 0.11% | 376,651 SH | Sept. 11, 2026 | Daily |
| IWO · iShares Trust | 0.11% | 518,012 SH | Sept. 11, 2026 | Daily |
| ESSC · Strategy Shares | 0.10% | 1,208 NS | July 31, 2026 | N-PORT |
| PWS · Pacer Funds Trust | 0.09% | 731 NS | July 31, 2026 | N-PORT |
| FSMD · FIDELITY COVINGTON TRUST | 0.09% | 74,841 NS | July 31, 2026 | N-PORT |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0.06% | 6,291 SH | Oct. 2, 2026 | Daily |
| BBSC · J.P. Morgan Exchange-Traded Fund Tr… | 0.06% | 14,515 NS | July 31, 2026 | N-PORT |
| IWM · iShares Trust | 0.05% | 1,405,603 SH | Sept. 11, 2026 | Daily |
| ISCG · iShares Trust | 0.05% | 17,010 SH | Sept. 11, 2026 | Daily |
| RSSL · Global X Funds | 0.05% | 26,368 NS | July 31, 2026 | N-PORT |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.05% | 317,008 SH | Aug. 19, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.04% | 194,930 NS | July 31, 2026 | N-PORT |
| FAD · First Trust Exchange-Traded AlphaDE… | 0.02% | 4,769 NS | July 31, 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.02% | 24,147 SH | Oct. 2, 2026 | Daily |
| VXF · VANGUARD INDEX FUNDS | 0.02% | 643,361 SH | Aug. 19, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | 0.02% | 111,259 SH | Aug. 19, 2026 | Daily |
| FHLC · FIDELITY COVINGTON TRUST | 0.02% | 17,567 NS | July 31, 2026 | N-PORT |
| WSML · iShares Trust | 0.01% | 2,945 SH | Sept. 11, 2026 | Daily |
| DFAC · Dimensional ETF Trust | 0.01% | 140,576 NS | July 31, 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 5,032 NS | July 31, 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 14,583 NS | July 31, 2026 | N-PORT |
| DFSU · Dimensional ETF Trust | 0.00% | 2,333 NS | July 31, 2026 | N-PORT |
| ITOT · iShares Trust | 0.00% | 80,153 SH | Sept. 11, 2026 | Daily |
| TILT · FlexShares Trust | 0.00% | 1,738 NS | July 31, 2026 | N-PORT |
| IWV · iShares Trust | 0.00% | 13,731 SH | Sept. 4, 2026 | Daily |
| DFUS · Dimensional ETF Trust | 0.00% | 10,631 NS | July 31, 2026 | N-PORT |
| DFUV · Dimensional ETF Trust | 0.00% | 341 NS | July 31, 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,885,403 SH | Aug. 19, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 4,620 SH | Aug. 19, 2026 | Daily |
| ISCB · iShares Trust | · | 2,364 SH | Sept. 11, 2026 | Daily |
STOK Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
rating · 20 analysts
BUY
Median target
$44.00
+71.7%
8 40.0%
Strong Buy
11 55.0%
Buy
1 5.0%
Hold
0 0.0%
Sell
0 0.0%
Strong Sell
12-Month Price Target
13 analysts · 2026-10-03Mean target $46.46 +81.3%
← Below all targets
Current price $25.62
Low$35.00
Mean$46.46
High$60.00
Peer comparison (GICS sub-industry) Key metrics vs sector peers
FY basis, prices as of each company's last fiscal year-end close.
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| STOK | $1.87B | -264.5 | 404.5% | -3.7% | -2.0% | · |
| GENB | · | · | · | · | · | · |
| NVAX | $1.09B | 2.6 | 64.7% | 39.2% | -977.1% | · |
| NTLA | $1.05B | -2.4 | 16.9% | -609.8% | -59.5% | · |
| ZYME | $1.97B | -24.4 | 38.9% | -76.6% | -26.9% | · |
| XNCR | $1.10B | -12.3 | 13.7% | -73.2% | -14.0% | · |
| SNDX | $1.84B | -6.4 | 627.8% | -165.6% | -257.1% | · |
| TSHA | $1.57B | -16.2 | 17.3% | -1115.3% | -44.0% | · |
| RARE | $2.22B | -3.9 | 20.2% | -85.4% | -1613.2% | · |
Latest News Recent headlines mentioning this company
Trading Signals Recent buy/sell signals with entry price and risk/reward ratio
No open signal right now — no card is filled, and that's honest.
My Metrics Your personal watchlist — selected rows from Full Fundamentals
Pick the metrics that matter to you — click the + next to any row in Full Fundamentals above.
Your selection is saved and follows you across all tickers.
Source: SEC 10-Q filed Aug 3, 2026