TRDA — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | $37,335,293 | 5,072,730 | 14.70% | Shares |
| 5AM Venture Management, LLC | $29,854,949 | 4,056,379 | 11.76% | Shares |
| MPM ASSET MANAGEMENT LLC | $25,410,160 | 4,381,062 | 10.01% | Shares |
| BlackRock, Inc. | $19,013,332 | 2,583,333 | 7.49% | Shares |
| VANGUARD GROUP INC | $16,781,689 | 1,632,460 | 6.61% | Shares |
| Merck & Co., Inc. | $12,804,692 | 1,739,768 | 5.04% | Shares |
| StepStone Group LP | $9,607,316 | 761,277 | 3.78% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $9,344,506 | 1,269,634 | 3.68% | Shares |
| MPM BIOIMPACT LLC | $9,222,470 | 1,253,053 | 3.63% | Shares |
| TCG Crossover Management, LLC | $7,803,293 | 1,060,230 | 3.07% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $7,024,524 | 954,419 | 2.77% | Shares |
| MILLENNIUM MANAGEMENT LLC | $5,622,738 | 763,959 | 2.21% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $5,281,368 | 717,430 | 2.08% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $5,148,591 | 699,537 | 2.03% | Shares |
| STATE STREET CORP | $4,391,543 | 596,677 | 1.73% | Shares |
| JPMORGAN CHASE & CO | $3,827,683 | 496,457 | 1.51% | Shares |
| CITADEL ADVISORS LLC | $2,902,217 | 394,323 | 1.14% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $2,769,577 | 376,136 | 1.09% | Shares |
| NORTHERN TRUST CORP | $2,281,173 | 309,942 | 0.90% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2,233,458 | 303,459 | 0.88% | Shares |
| Nantahala Capital Management, LLC | $2,212,232 | 300,575 | 0.87% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1,870,397 | 254,130 | 0.74% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1,450,921 | 197,136 | 0.57% | Shares |
| Longaeva Partners L.P. | $1,436,944 | 195,237 | 0.57% | Shares |
| MORGAN STANLEY | $1,410,544 | 191,650 | 0.56% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $1,405,760 | 191,000 | 0.55% | Shares |
| Quantinno Capital Management LP | $1,389,855 | 188,839 | 0.55% | Shares |
| Lynx1 Capital Management LP | $1,314,540 | 178,606 | 0.52% | Shares |
| GOLDMAN SACHS GROUP INC | $1,305,247 | 177,343 | 0.51% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $1,233,875 | 167,646 | 0.49% | Shares |
| Woodline Partners LP | $1,071,616 | 145,600 | 0.42% | Shares |
| Trexquant Investment LP | $1,031,452 | 140,143 | 0.41% | Shares |
| MOORE CAPITAL MANAGEMENT, LP | $772,800 | 105,000 | 0.30% | Shares |
| Cubist Systematic Strategies, LLC | $711,521 | 122,676 | 0.28% | Shares |
| XTX Topco Ltd | $701,680 | 95,337 | 0.28% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $699,524 | 95,044 | 0.28% | Shares |
| Allspring Global Investments Holdings, LLC | $688,440 | 93,538 | 0.27% | Shares |
| ROYCE & ASSOCIATES LP | $610,159 | 82,902 | 0.24% | Shares |
| AMERICAN CENTURY COMPANIES INC | $586,599 | 79,701 | 0.23% | Shares |
| Bank of New York Mellon Corp | $581,955 | 79,070 | 0.23% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $533,747 | 72,520 | 0.21% | Shares |
| AMERIPRISE FINANCIAL INC | $518,107 | 70,395 | 0.20% | Shares |
| Qube Research & Technologies Ltd | $448,018 | 60,872 | 0.18% | Shares |
| CANTOR FITZGERALD, L. P. | $441,600 | 60,000 | 0.17% | Shares |
| BANK OF AMERICA CORP /DE/ | $426,343 | 57,927 | 0.17% | Shares |
| Nuveen, LLC | $417,879 | 56,777 | 0.16% | Shares |
| ALLIANCEBERNSTEIN L.P. | $399,297 | 31,640 | 0.16% | Shares |
| Susquehanna Portfolio Strategies, LLC | $398,272 | 54,113 | 0.16% | Shares |
| TD Asset Management Inc | $394,408 | 53,588 | 0.16% | Shares |
| ExodusPoint Capital Management, LP | $388,365 | 52,767 | 0.15% | Shares |
| Nan Fung Group Holdings Ltd | $361,244 | 49,082 | 0.14% | Shares |
| TWO SIGMA INVESTMENTS, LP | $341,519 | 46,402 | 0.13% | Shares |
| Invesco Ltd. | $326,372 | 44,344 | 0.13% | Shares |
| UBS Group AG | $305,911 | 41,564 | 0.12% | Shares |
| GREAT LAKES ADVISORS, LLC | $283,441 | 38,511 | 0.11% | Shares |
| MARTINGALE ASSET MANAGEMENT L P | $281,616 | 38,263 | 0.11% | Shares |
| HSBC HOLDINGS PLC | $278,266 | 36,470 | 0.11% | Shares |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $276,015 | 37,502 | 0.11% | Shares |
| RHUMBLINE ADVISERS | $270,421 | 36,743 | 0.11% | Shares |
| Y-Intercept (Hong Kong) Ltd | $255,296 | 34,687 | 0.10% | Shares |
| Brevan Howard Capital Management LP | $250,012 | 33,969 | 0.10% | Shares |
| Graham Capital Management, L.P. | $246,244 | 33,457 | 0.10% | Shares |
| D. E. Shaw & Co., Inc. | $238,442 | 32,397 | 0.09% | Shares |
| Odyssean, LLC | $230,405 | 31,305 | 0.09% | Shares |
| Corton Capital Inc. | $225,324 | 38,849 | 0.09% | Shares |
| IEQ CAPITAL, LLC | $218,437 | 29,679 | 0.09% | Shares |
| BARCLAYS PLC | $210,495 | 28,600 | 0.08% | Shares |
| Point72 Asset Management, L.P. | $209,760 | 28,500 | 0.08% | Shares |
| China Universal Asset Management Co., Ltd. | $204,446 | 27,778 | 0.08% | Shares |
| Verdad Advisers, LP | $202,400 | 27,500 | 0.08% | Shares |
| DEUTSCHE BANK AG\ | $195,452 | 26,556 | 0.08% | Shares |
| Voleon Capital Management LP | $186,385 | 25,324 | 0.07% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $184,000 | 25,000 | 0.07% | Shares |
| WELLS FARGO & COMPANY/MN | $183,279 | 24,902 | 0.07% | Shares |
| Jump Financial, LLC | $177,170 | 24,072 | 0.07% | Shares |
| Inscription Capital, LLC | $176,206 | 23,941 | 0.07% | Shares |
| Russell Investments Group, Ltd. | $172,591 | 23,450 | 0.07% | Shares |
| AlphaQuest LLC | $160,666 | 15,629 | 0.06% | Shares |
| Mariner, LLC | $159,779 | 21,707 | 0.06% | Shares |
| MERCER GLOBAL ADVISORS INC /ADV | $152,006 | 20,653 | 0.06% | Shares |
| MetLife Investment Management, LLC | $129,941 | 17,655 | 0.05% | Shares |
| ADAR1 Capital Management, LLC | $114,080 | 15,500 | 0.04% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $114,028 | 15,493 | 0.04% | Shares |
| CITIGROUP INC | $108,854 | 14,790 | 0.04% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $99,735 | 13,551 | 0.04% | Shares |
| Cerity Partners LLC | $99,442 | 13,511 | 0.04% | Shares |
| Quadrature Capital Ltd | $97,572 | 13,257 | 0.04% | Shares |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $88,364 | 12,769 | 0.03% | Shares |
| CWM, LLC | $85,665 | 6,788 | 0.03% | Shares |
| Police & Firemen's Retirement System of New Jersey | $69,707 | 9,471 | 0.03% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $65,335 | 8,877 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $64,856 | 8,812 | 0.03% | Shares |
| State of Wyoming | $36,903 | 5,014 | 0.01% | Shares |
| Arax Advisory Partners | $32,958 | 4,478 | 0.01% | Shares |
| Versant Capital Management, Inc | $26,702 | 4,205 | 0.01% | Shares |
| STRS OHIO | $23,552 | 3,200 | 0.01% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $21,874 | 2,972 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $21,462 | 2,916 | 0.01% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $19,784 | 2,688 | 0.01% | Shares |
| Legal & General Group Plc | $18,807 | 2,557 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $17,789 | 2,417 | 0.01% | Shares |
| FMR LLC | $15,962 | 2,169 | 0.01% | Shares |
| FEDERATED HERMES, INC. | $14,484 | 1,968 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $12,777 | 1,736 | 0.01% | Shares |
| PNC Financial Services Group, Inc. | $8,354 | 1,135 | 0.00% | Shares |
| Point72 (DIFC) Ltd | $7,876 | 1,358 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $6,000 | 882 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $5,976 | 812 | 0.00% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5,490 | 435 | 0.00% | Shares |
| Allworth Financial LP | $4,762 | 647 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $4,724 | 642 | 0.00% | Shares |
| Essential Partners LLC | $4,394 | 597 | 0.00% | Shares |
| Sterling Capital Management LLC | $4,364 | 593 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $3,992 | 542,316 | 0.00% | Shares |
| GAMMA Investing LLC | $3,864 | 525 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $2,945 | 400,862 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2,937 | 399 | 0.00% | Shares |
| True Wealth Design, LLC | $2,260 | 307 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $2,009 | 273 | 0.00% | Shares |
| Optiver Holding B.V. | $1,722 | 234 | 0.00% | Shares |
| Private Wealth Management Group, LLC | $1,561 | 212 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $1,435 | 195 | 0.00% | Shares |
| MassMutual Private Wealth & Trust, FSB | $1,369 | 186 | 0.00% | Shares |
| IFP Advisors, Inc | $1,259 | 171 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $1,054 | 143 | 0.00% | Shares |
| Clearstead Advisors, LLC | $1,038 | 141 | 0.00% | Shares |
| Cornerstone Financial Management LLC | $670 | 91 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $648 | 88,005 | 0.00% | Shares |
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | $640 | 87 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $523 | 71 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $339 | 46 | 0.00% | Shares |
| Wealth Enhancement Trust Services, Inc. | $316 | 43 | 0.00% | Shares |
| HARBOR CAPITAL ADVISORS, INC. | $245 | 33,351 | 0.00% | Shares |
| Quarry LP | $184 | 25 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $15 | 2 | 0.00% | Shares |