IOVA Iovance Biotherapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$7.27
Price · Aug 18, 2026
Fundamentals as of Aug 6, 2026

About Iovance Biotherapeutics, Inc. - Common Stock Company overview from Wikipedia

Iovance Biotherapeutics, Inc. is a biopharmaceutical based in San Carlos, California. The company works to develop tumor-infiltrating lymphocyte (TIL) therapies against cancer.

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Iovance Biotherapeutics, Inc. is a biopharmaceutical based in San Carlos, California. The company works to develop tumor-infiltrating lymphocyte (TIL) therapies against cancer.

## History

The company was founded in 2007 as Genesis Biopharma. In 2013, Lion merged with Genesis Biopharma аnd became Lion Bio Pharma, which was then rebranded to Iovance in 2017.

In 2024, the US FDA gave accelerated approval to Lifileucel, marketed under the brand name Amtagvi, the company's tumor-infiltrating lymphocyte drug for the treatment of unresectable or metastatic melanoma.

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

IOVA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$7.27
Market Cap
$2.99B
P/E (TTM)
-6.7
EPS (TTM)
$-1.09
Revenue (TTM)
$264M
Div Yield
ROE
-56.0%
Debt/Equity
0.0
52W Range
$2 – $7

IOVA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $264M
6-point trend, +263502000.00
2016-12-31 2025-12-31
EPS $-1.09
7-point trend, +31.4%
2019-12-31 2025-12-31
Free Cash Flow $-336M
10-point trend, -883.5%
2016-12-31 2025-12-31
Margins -148.4%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
IOVA
Peer Median
P/E (TTM)
5-point trend, +70.7%
-6.7
P/S (TTM)
3-point trend, -99.8%
11.4
18.3
P/B
5-point trend, -66.6%
4.3
3.3
EV / EBITDA
-6.9
Price / FCF
5-point trend, +70.4%
-8.9

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
IOVA
Peer Median
Operating Margin
3-point trend, +99.6%
-153.1%
Net Profit Margin
3-point trend, +99.6%
-148.4%
-180.4%
ROA
5-point trend, +3.2%
-42.9%
-36.2%
ROE
5-point trend, -7.9%
-56.0%
-43.7%
ROIC
3-point trend, +26.6%
-57.4%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
IOVA
Peer Median
Debt / Equity
0.0
Current Ratio
5-point trend, -43.8%
3.2
9.7
Quick Ratio
5-point trend, -51.5%
2.7

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
IOVA
Peer Median
Revenue YoY
5-point trend, +263502000.00
60.6%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
IOVA
Peer Median
EPS (Diluted)
5-point trend, +51.1%
$-1.09

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
IOVA
Peer Median

IOVA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 15 analysts
  • Strong Buy 3 20.0%
  • Buy 9 60.0%
  • Hold 3 20.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

9 analysts · 2026-08-19
Median target $9.00 +23.8%
Mean target $9.22 +26.9%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.03%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.11 $-0.13 0.02%
March 31, 2026 $-0.19 $-0.15 -0.04%
Dec. 31, 2025 $-0.18 $-0.18 -0.00%
Sept. 30, 2025 $-0.25 $-0.26 0.01%
June 30, 2025 $-0.33 $-0.29 -0.04%
March 31, 2025 $-0.36 $-0.24 -0.12%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
IOVA $1.12B -2.5 60.6% -148.4% -56.0%
IDYA $3.04B -27.0 3024.4% -52.0% -11.5%
CLDX $1.81B -7.0 -78.0% -16748.0% -43.8%
ARQT $3.58B -223.4 91.3% -4.3% -9.8%
GRAL $3.45B -7.7 17.2% -277.5% -16.7%
IMNM $2.43B -8.8 -23.2% -3060.0% -47.0%
IRON $3.01B -13.2 -31.3%
NRIX $1.80B -5.8 53.9% -314.9% -53.6%
BEAM $2.82B -34.2 120.0% -57.2% -7.0%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 8-point trend, +263502000.00 $264M $164M $1M · · · · $0 $0 $0 $0 $0
Cost of Revenue 3-point trend, +16665.2% $173M $93M $1M · · · · · · · · ·
R&D Expense 12-point trend, +7701.2% $300M $276M $333M $295M $259M $202M $166M $100M $72M $27M $15M $4M
SG&A Expense 12-point trend, +1759.4% $152M $152M $106M $104M $84M $60M $41M $28M $21M $27M $12M $8M
Operating Expenses 12-point trend, +5438.2% $667M $559M $462M $399M $343M $262M $207M $128M $93M $54M $28M $12M
Operating Income 12-point trend, -3249.9% $-403M $-395M $-461M $-399M $-343M $-262M $-207M $-128M $-93M $-54M $-28M $-12M
Interest Expense · · · · · · · · · · · $-5.7K
Interest Income 12-point trend, +171683.3% $10M $20M $13M $3M $451.0K $2M $9M $5M $813.0K $745.0K $200.0K $6.0K
Other Non-op 2-point trend, +3233.3% · · · · · · · · · · $200.0K $6.0K
Pretax Income 5-point trend, -14.8% $-393M $-375M $-448M $-396M $-342M · · · · · · ·
Income Tax 12-point trend, -2071000.00 $-2M $-3M $-3M $0 $0 $0 $0 $0 $0 $0 $0 $0
Net Income 12-point trend, -3148.7% $-391M $-372M $-444M $-396M $-342M $-260M $-198M $-124M $-92M $-53M $-28M $-12M
EPS (Basic) 7-point trend, +31.4% $-1.09 $-1.28 $-1.89 $-2.49 $-2.23 $-1.88 $-1.59 · · · · ·
EPS (Diluted) 7-point trend, +31.4% $-1.09 $-1.28 $-1.89 $-2.49 $-2.23 $-1.88 $-1.59 · · · · ·
Shares (Basic) 7-point trend, +187.4% 357,345 289,877 235,131 159,259 153,406 138,301 124,336 · · · · ·
Shares (Diluted) 7-point trend, +187.4% 357,345 289,877 235,131 159,259 153,406 138,301 124,336 · · · · ·
EBITDA 11-point trend, -1301.6% $-390M $-383M $-449M $-390M $-340M $-261M $-206M $-128M $-93M $-54M $-28M ·
Balance Sheet 28
Annual Balance Sheet data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +263.1% $163M $116M $115M $232M $78M $67M $14M $82M $145M $107M $34M $45M
Short-term Investments 12-point trend, +133902000.00 $134M $208M $165M $240M $426M $562M $293M $386M $0 $60M $70M $0
Receivables 3-point trend, +54501.3% $82M $69M $151.0K · · · · · · · · ·
Inventory 3-point trend, +398.2% $52M $52M $10M · · · · · · · · ·
Prepaid Expense 12-point trend, +17450.0% $12M $12M $17M $7M $4M $7M $9M $7M $4M $3M $277.0K $66.0K
Current Assets 12-point trend, +884.3% $443M $457M $308M $479M $508M $636M $316M $475M $149M $170M $104M $45M
PP&E (Net) 12-point trend, +8458.2% $131M $109M $114M $105M $101M $59M $9M $3M $2M $2M $2M $2M
PP&E (Gross) 12-point trend, +10895.2% $180M $145M $142M $122M $110M $65M $13M $7M $5M $4M $3M $2M
Accum. Depreciation 12-point trend, +46794.2% $49M $36M $28M $17M $9M $6M $4M $4M $3M $2M $1M $104.0K
Intangibles 3-point trend, +21.8% $279M $282M $229M · · · · · · · · ·
Other Non-current Assets 10-point trend, +8166000.00 $8M $369.0K $270.0K $189.0K $2M $13M $3M $3M $4M $0 · ·
Total Assets 12-point trend, +1863.5% $913M $910M $780M $664M $777M $768M $345M $481M $155M $172M $106M $47M
Accounts Payable 12-point trend, +1675.6% $22M $28M $33M $27M $27M $14M $16M $3M $1M $863.0K $958.0K $1M
Accrued Liabilities 12-point trend, +33789.0% $111M $82M $69M $52M $57M $35M $16M $12M $8M $4M $672.0K $328.0K
Short-term Debt $1M · · · · · · · · · · ·
Current Liabilities 12-point trend, +8224.8% $138M $122M $110M $91M $89M $55M $39M $14M $10M $5M $2M $2M
Capital Leases 8-point trend, +44401000.00 $44M $44M $67M $72M $65M $45M $4M $0 · · · ·
Deferred Tax 3-point trend, +83.5% $32M $32M $17M · · · · · · · · ·
Other Non-current Liabilities 3-point trend, +4993.0% · · · · · $12M $2M $230.0K · · · ·
Total Liabilities 9-point trend, +2069.3% $215M $200M $196M $164M $156M $112M $46M $15M $10M · · ·
Total Debt $1M · · · · · · · · · · ·
Common Stock 12-point trend, +750.0% $17.0K $13.0K $11.0K $8.0K $7.0K $6.0K $5.0K $5.0K $3.0K $3.0K $2.0K $2.0K
Paid-in Capital 12-point trend, +2753.8% $3.46B $3.10B $2.59B $2.07B $1.79B $1.49B $869M $839M $395M $324M $208M $121M
Retained Earnings 12-point trend, -3525.2% $-2.78B $-2.38B $-2.01B $-1.57B $-1.17B $-830M $-571M $-373M $-249M $-157M $-104M $-77M
AOCI 12-point trend, +16440000.00 $16M $-1M $3M $-902.0K $-601.0K $19.0K $220.0K $-42.0K $0 $29.0K $48.0K $0
Stockholders' Equity 12-point trend, +1457.8% $699M $710M $585M $500M $622M $656M $299M $466M $145M $167M $104M $45M
Liabilities + Equity 12-point trend, +1863.5% $913M $910M $780M $664M $777M $768M $345M $481M $155M $172M $106M $47M
Shares Outstanding 12-point trend, +1120.6% 411,938,061 305,252,194 256,135,715 187,812,072 157,004,742 147,874,917 126,411,808 123,415,576 73,164,914 62,248,074 48,547,720 33,750,188
Cash Flow 17
Annual Cash Flow data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
D&A 12-point trend, +14515.9% $13M $11M $12M $9M $3M $1M $1M $956.0K $952.0K $978.0K $999.0K $88.0K
Stock-based Comp 12-point trend, +1514.4% $62M $110M $63M $84M $70M $41M $24M $20M $12M $19M $9M $4M
Deferred Tax 3-point trend, +40.5% $-2M $-3M $-3M · · · · · · · · ·
Amort. of Intangibles 4-point trend, +23077000.00 $23M $26M $10M $0 · · · · · · · ·
Restructuring $5M · · · · · · · · · · ·
Other Non-cash 7-point trend, +22.6% $16M $-100M $12M $10M $41M $12M $13M · · · · ·
Operating Cash Flow 12-point trend, -3402.9% $-302M $-353M $-362M $-293M $-228M $-205M $-159M $-101M $-79M $-33M $-18M $-9M
CapEx 12-point trend, +2025.4% $34M $11M $22M $20M $38M $47M $7M $1M $1M $2M $1M $2M
Investing Cash Flow 11-point trend, +166.7% $47M $-96M $-155M $256M $132.0K $-318M $90M $-386M $59M $9M $-71M ·
Debt Issued · · · · $1M · · · · · · ·
Net Debt Issued · · · · $1M · · · · · · ·
Stock Issued 11-point trend, +850.1% $306M $397M $463M $190M $203M $567M · $399M $54M $96M $68M $32M
Net Stock Activity 10-point trend, +348.4% $306M $397M $463M $190M $203M $567M · $399M $54M $96M $68M ·
Financing Cash Flow 11-point trend, +284.3% $301M $391M $463M $190M $239M $576M $6M $424M $59M $97M $78M ·
Net Change in Cash 10-point trend, +86.3% $47M $-59M $-57M $154M $11M · · $-63M $39M $73M $-11M $25M
Taxes Paid Flat — no change across 8 periods $0 $0 $0 · · · · $0 $0 $0 $0 $0
Free Cash Flow 11-point trend, -1622.2% $-336M $-364M $-384M $-313M $-266M $-252M $-166M $-102M $-80M $-34M $-20M ·
Profitability 7
Annual Profitability data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 3-point trend, +99.6% -153.1% -240.9% -38735.0% · · · · · · · · ·
Net Margin 3-point trend, +99.6% -148.4% -226.8% -37345.4% · · · · · · · · ·
Pretax Margin 3-point trend, +99.6% -149.2% -228.6% -37638.0% · · · · · · · · ·
EBITDA Margin 3-point trend, +99.6% -148.2% -233.6% -37762.1% · · · · · · · · ·
ROA 11-point trend, -17.9% -42.9% -44.0% -61.5% -54.9% -44.3% -46.6% -47.9% -38.9% -56.3% -38.1% -36.4% ·
ROE 11-point trend, -50.6% -56.0% -50.2% -70.6% -88.6% -51.9% -37.9% -60.4% -34.3% -58.9% -39.0% -37.2% ·
ROIC 3-point trend, +26.6% -57.4% -55.2% -78.2% · · · · · · · · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -95.0% 3.2 3.7 2.8 5.2 5.7 11.6 8.1 33.0 15.1 34.1 63.8 ·
Quick Ratio 11-point trend, -94.7% 2.7 3.2 2.5 5.2 5.7 11.5 7.9 32.5 14.7 33.5 51.4 ·
Debt / Equity 0.0 · · · · · · · · · · ·
Efficiency 3
Annual Efficiency data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 7-point trend, +0.29 0.3 0.2 0.0 · · · · 0.0 0.0 0.0 0.0 ·
Inventory Turnover 3-point trend, +61.8% 3.4 4.0 2.1 · · · · · · · · ·
Receivables Turnover 3-point trend, -78.0% 3.5 4.7 15.7 · · · · · · · · ·
Per Share 5
Annual Per Share data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, -20.9% $1.70 $2.33 $2.28 $2.66 $3.96 $4.47 $2.37 $3.78 $1.99 $2.68 $2.14 ·
Revenue / Share 3-point trend, +14482.1% $737.39 $566.00 $5.06 · · · · · · · · ·
Cash Flow / Share 5-point trend, +43.0% $-846.26 $-1217.68 $-1538.80 $-1838.24 $-1485.87 · · · · · · ·
Cash / Share 11-point trend, +40.9% $0.40 $0.38 $0.45 $1.23 $0.50 $0.46 $0.11 $0.67 $1.99 $1.71 $0.28 ·
EPS (TTM) 7-point trend, +31.4% $-1.09 $-1.28 $-1.89 $-2.49 $-2.23 $-1.88 $-1.59 · · · · ·
Growth Rates 1
Annual Growth Rates data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 2-point trend, -99.6% 60.6% 13699.0% · · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for IOVA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +263502000.00 $264M $164M $1M $0 $0 $0 $0 $0 $0 $0 $0 $0
Net Income TTM 12-point trend, -3148.7% $-391M $-372M $-444M $-396M $-342M $-260M $-198M $-124M $-92M $-53M $-28M $-12M
Market Cap 11-point trend, +200.1% $1.12B $2.26B $2.08B $1.20B $3.00B $6.81B $3.50B $1.09B $585M $433M $375M ·
Enterprise Value $829M · · · · · · · · · · ·
P/E 7-point trend, +85.6% -2.5 -5.8 -4.3 -2.6 -8.6 -24.7 -17.4 · · · · ·
P/S 3-point trend, -99.8% 4.3 13.8 1751.4 · · · · · · · · ·
P/B 11-point trend, -55.3% 1.6 3.2 3.6 2.4 4.8 10.4 11.7 2.3 4.0 2.6 3.6 ·
P / Tangible Book 6-point trend, -74.2% 2.7 5.3 5.9 2.4 4.8 10.4 · · · · · ·
P / Cash Flow 11-point trend, +81.8% -3.7 -6.4 -5.8 -4.1 -13.1 -33.2 -22.0 -10.8 -7.4 -13.2 -20.4 ·
P / FCF 11-point trend, +82.6% -3.3 -6.2 -5.4 -3.8 -11.3 -27.1 -21.1 -10.7 -7.3 -12.7 -19.2 ·
EV / EBITDA -2.1 · · · · · · · · · · ·
EV / FCF -2.5 · · · · · · · · · · ·
EV / Revenue 3.1 · · · · · · · · · · ·
Earnings Yield 7-point trend, -595.6% -39.9% -17.3% -23.2% -39.0% -11.7% -4.0% -5.7% · · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $264M$164M$1M
Operating Margin % -153.1%-240.9%-38735.0%
Net Income $-391M$-372M$-444M$-396M$-342M
Diluted EPS $-1.09$-1.28$-1.89$-2.49$-2.23
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.0
Current Ratio 3.23.72.85.25.7
Quick Ratio 2.73.22.55.25.7
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-336M$-364M$-384M$-313M$-266M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 316 filers · $915.1M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
49 (-15 vs prior Q) 35 (0 vs prior Q) 124 (+7 vs prior Q) 62 (-4 vs prior Q) +44.5M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
MHR FUND MANAGEMENT LLC $120,503,148 28,967,103 13.17% Shares
STATE STREET CORP $101,829,595 24,478,268 11.13% Shares
TWO SIGMA INVESTMENTS, LP $79,084,500 19,010,697 8.64% Shares
VANGUARD CAPITAL MANAGEMENT LLC $75,729,672 18,204,248 8.28% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $59,858,236 14,388,999 6.54% Shares
GEODE CAPITAL MANAGEMENT, LLC $36,971,836 8,885,825 4.04% Shares
MILLENNIUM MANAGEMENT LLC $35,467,823 8,525,919 3.88% Shares
DIMENSIONAL FUND ADVISORS LP $24,866,629 5,977,555 2.72% Shares
Palo Alto Investors LP $22,032,229 5,296,209 2.41% Shares
BANK OF AMERICA CORP /DE/ $19,240,719 4,625,173 2.10% Shares
JUPITER ASSET MANAGEMENT LTD $18,865,933 4,535,080 2.06% Shares
JANE STREET GROUP, LLC $17,758,903 4,268,967 1.94% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $13,393,769 3,219,656 1.46% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $11,097,216 2,667,600 1.21% Call option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $11,052,038 2,656,740 1.21% Shares
GOLDMAN SACHS GROUP INC $10,683,579 2,568,168 1.17% Shares
VANGUARD FIDUCIARY TRUST CO $10,578,372 2,542,878 1.16% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $9,953,632 2,392,700 1.09% Put option
D. E. Shaw & Co., Inc. $8,915,437 2,143,134 0.97% Shares
CITADEL ADVISORS LLC $8,756,758 2,104,990 0.96% Shares
Long Focus Capital Management, LLC $8,736,000 2,100,000 0.95% Shares
Orion Investment Co $8,624,520 2,073,202 0.94% Shares
TWO SIGMA ADVISERS, LP $8,230,950 3,015,000 0.90% Shares
Xcelsior Advisor Partners LLC $7,421,124 1,783,924 0.81% Shares
Rhenman & Partners Asset Management AB $7,094,160 1,705,327 0.78% Shares
Knott David M Jr $6,656,000 1,600,000 0.73% Shares
RICE HALL JAMES & ASSOCIATES, LLC $6,405,734 1,539,840 0.70% Shares
B Group, Inc. $6,240,000 1,500,000 0.68% Shares
Invenomic Capital Management LP $6,167,595 1,482,595 0.67% Shares
WELLS FARGO & COMPANY/MN $5,994,285 1,440,934 0.66% Shares
VANGUARD GROUP INC $5,760,305 2,110,002 0.63% Shares
Woodline Partners LP $5,671,020 1,363,226 0.62% Shares
FMR LLC $5,629,570 1,353,262 0.62% Shares
JPMORGAN CHASE & CO $4,919,364 1,168,495 0.54% Shares
Mirador Capital Partners LP $4,493,998 1,080,288 0.49% Shares
Susquehanna Portfolio Strategies, LLC $4,391,217 1,055,581 0.48% Shares
SECTOR GAMMA AS $4,028,819 968,466 0.44% Shares
CITIGROUP INC $3,574,126 859,165 0.39% Shares
CITADEL ADVISORS LLC $3,385,824 813,900 0.37% Call option
BlackRock, Inc. $3,047,371 732,541 0.33% Shares
JANE STREET GROUP, LLC $3,037,216 730,100 0.33% Call option
CITADEL ADVISORS LLC $2,996,864 720,400 0.33% Put option
Swiss National Bank $2,922,633 702,556 0.32% Shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC $2,862,637 688,134 0.31% Shares
AMERICAN CENTURY COMPANIES INC $2,848,240 684,673 0.31% Shares
QVT Financial LP $2,822,826 678,564 0.31% Shares
LPL Financial LLC $2,750,070 661,075 0.30% Shares
683 Capital Management, LLC $2,680,288 644,300 0.29% Put option
RHUMBLINE ADVISERS $2,471,712 594,164 0.27% Shares
Mariner, LLC $2,101,647 505,190 0.23% Shares
ALGERT GLOBAL LLC $1,975,746 474,939 0.22% Shares
CM Management, LLC $1,872,000 450,000 0.20% Shares
Bank of New York Mellon Corp $1,855,065 445,929 0.20% Shares
Rafferty Asset Management, LLC $1,675,981 402,880 0.18% Shares
Raiffeisen Bank International AG $1,599,800 380,000 0.17% Shares
Cresset Asset Management, LLC $1,596,550 383,786 0.17% Shares
Balyasny Asset Management L.P. $1,552,861 373,284 0.17% Shares
CORSAIR CAPITAL MANAGEMENT, L.P. $1,539,200 370,000 0.17% Shares
ALLIANCEBERNSTEIN L.P. $1,477,850 421,040 0.16% Shares
JANE STREET GROUP, LLC $1,436,032 345,200 0.16% Put option
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $1,420,778 404,780 0.16% Shares
Squarepoint Ops LLC $1,354,421 325,582 0.15% Shares
Kennondale Capital Management LLC $1,323,662 318,188 0.14% Shares
TUDOR INVESTMENT CORP ET AL $1,222,994 293,989 0.13% Shares
IEQ CAPITAL, LLC $1,218,722 292,962 0.13% Shares
STATE OF WISCONSIN INVESTMENT BOARD $1,186,078 285,115 0.13% Shares
Virtus Investment Advisers, LLC $1,185,683 285,020 0.13% Shares
Creative Planning $1,171,914 281,710 0.13% Shares
Quadrature Capital Ltd $1,160,378 278,937 0.13% Shares
MORGAN STANLEY $1,142,544 274,650 0.12% Shares
ExodusPoint Capital Management, LP $1,125,925 270,655 0.12% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $1,090,532 262,147 0.12% Shares
Man Group plc $1,052,309 252,959 0.11% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $1,036,826 295,392 0.11% Shares
VANGUARD ASSET MANAGEMENT, Ltd $1,025,353 246,479 0.11% Shares
TD Asset Management Inc $1,019,416 245,052 0.11% Shares
GROUP ONE TRADING LLC $988,711 237,671 0.11% Shares
MetLife Investment Management, LLC $965,748 232,151 0.11% Shares
UBS Group AG $952,890 229,060 0.10% Shares
Baird Financial Group, Inc. $924,934 222,340 0.10% Shares
Walleye Capital LLC $923,104 221,900 0.10% Call option
Vanguard Global Advisers, LLC $900,228 216,401 0.10% Shares
PROFUND ADVISORS LLC $849,530 204,214 0.09% Shares
Parametrica Management Ltd $814,852 195,878 0.09% Shares
Engineers Gate Manager LP $790,546 190,035 0.09% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $762,349 183,257 0.08% Shares
Invesco Ltd. $657,292 158,003 0.07% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $646,872 155,498 0.07% Shares
OSAIC HOLDINGS, INC. $635,207 152,695 0.07% Shares
Intellectus Partners, LLC $631,677 151,846 0.07% Shares
Leonteq Securities AG $624,000 150,000 0.07% Shares
Soleus Capital Management, L.P. $624,000 150,000 0.07% Shares
ADAR1 Capital Management, LLC $607,734 146,090 0.07% Shares
Headlands Technologies LLC $577,570 138,839 0.06% Shares
Sugar Maple Asset Management, LLC $561,600 135,000 0.06% Shares
PORTLAND INVESTMENT COUNSEL INC. $540,800 130,000 0.06% Shares
SIMPLEX TRADING, LLC $524,605 126,107 0.06% Shares
JANUS HENDERSON GROUP PLC $497,977 141,672 0.05% Shares
Police & Firemen's Retirement System of New Jersey $488,292 117,378 0.05% Shares
BARCLAYS PLC $482,759 116,048 0.05% Shares

Company insiders 37 insiders · 9 officers · 14 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Frederick G Vogt Interim CEO & General Counsel June 5, 2026 M 562,492 0 0 $0
Maria Fardis President and CEO Jan. 4, 2021 A 298,786 0 0 $0
Paul Kessler Chair,CEO, Pres., Pr.Acctg July 24, 2013 A 15,693,215 0 0 $0
Jean-Marc Bellemin Chief Financial Officer June 2, 2025 M 60,529 0 0 $0
Timothy E Morris Chief Financial Officer March 4, 2019 A 0 0 $0
Igor Bilinsky Chief Operating Officer June 5, 2026 M 133,920 0 0 $0
Raj K. Puri Chief Regulatory Officer June 16, 2026 A 248,114 0 0 $0
Finckenstein Friedrich Graf Chief Medical Officer June 5, 2026 M 140,111 0 0 $0
Michael Swartzburg Vice President, Finance (PAO) Jan. 4, 2021 A 0 0 $0
Iain D. Dukes Director June 16, 2026 A 54,000 0 0 $0
Athena Countouriotis Director June 16, 2026 A 0 0 $0
Ryan D Maynard Director June 16, 2026 A 7,500 0 0 $0
Michael Weiser Director June 16, 2026 A 112,632 0 0 $0
Wendy L Yarno Director June 13, 2025 A 0 0 $0
Wayne P. Rothbaum Director March 1, 2024 A 28,067,333 0 0 $0
Merrill A Mcpeak Director March 1, 2024 A 320,150 0 0 $0
Wendy L Dixon Director June 10, 2022 A 0 0 $0
Ayer Capital Management, LP Director May 22, 2013 C 560,401,150 0 0 $0
Martin Schroeder Director Aug. 22, 2011 P 1,000,000 0 0 $0
Mark J Ahn Director May 26, 2010 A 0 0 $0
Bristol Investment Fund, Ltd. 10% owner Nov. 6, 2014 S 3,867,863 0 0 $0
Hamilton Atlantic 10% owner March 31, 2010 J 0 0 0 $0
Daniel Gordon Kirby Aug. 10, 2026 M 154,511 0 0 $0
Corleen M. Roche Aug. 6, 2026 M 28,757 0 0 $0
Jay Venkatesan June 1, 2017 A 0 0 $0
Sanford Hillsberg June 1, 2017 A 100,000 0 0 $0
Gregory T Schiffman Nov. 14, 2016 A 0 0 $0
Molly Henderson June 10, 2016 A 0 0 $0
Michael Lotze March 28, 2016 A 0 0 $0
James G. Bender March 11, 2016 A 88,726 0 0 $0
Elma Hawkins March 11, 2016 A 176,567 0 0 $0
Steven A. Fischkoff Feb. 4, 2016 A 0 0 $0
Laszlo Radvanyi Dec. 5, 2014 A 180,000 0 0 $0
Michael D Handelman Dec. 5, 2014 A 0 0 $0
Manish Singh Dec. 30, 2013 A 2,546,000 0 0 $0
Richard Mckilligan March 29, 2011 J 1,220,016 0 0 $0
Robert T. Brooke March 25, 2011 J 4,440,008 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 6 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Quogue Capital LLC, Wayne P. Rothbaum ×5 filings March 19, 2024 Initial filing SEC
Undisclosed reporting person Feb. 11, 2015 Initial filing SEC
Bristol Investment Fund, Ltd., Bristol Capital, LLC ×4 filings Feb. 20, 2014 Initial filing SEC
Robert T. Brooke ×2 filings May 12, 2011 Initial filing SEC
Hamilton Atlantic Nov. 5, 2010 Initial filing M&A / sale SEC
Undisclosed reporting person March 29, 2010 Initial filing M&A / sale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 49 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IDNA · iShares Trust 2.65% 841,830 SH Aug. 8, 2026 Daily
BBP · ETFis Series Trust I 2.44% 430,167 NS April 30, 2026 N-PORT
QQQS · Invesco Exchange-Traded Fund Trust … 0.77% 27,306 SH Aug. 8, 2026 Daily
CANC · Tema ETF Trust 0.65% 280,048 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.30% 466,051 NS April 30, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.23% 1,035,381 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.19% 24,302 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.19% 2,852,725 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.16% 3,686,426 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.11% 346,628 SH Aug. 8, 2026 Daily
GINN · Goldman Sachs ETF Trust 0.09% 45,126 NS May 31, 2026 N-PORT
TMFX · RBB Fund, Inc. 0.09% 6,714 NS May 31, 2026 N-PORT
BIB · ProShares Trust 0.08% 15,232 NS May 31, 2026 N-PORT
IWM · iShares Trust 0.08% 10,143,030 SH Aug. 8, 2026 Daily
ISCV · iShares Trust 0.07% 76,919 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.07% 452,513 NS May 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.05% 261,797 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.05% 2,290,247 SH Aug. 8, 2026 Daily
TECB · iShares Trust 0.05% 38,134 SH Aug. 8, 2026 Daily
DFAS · Dimensional ETF Trust 0.04% 1,472,303 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.03% 15,876 NS May 31, 2026 N-PORT
RSSL · Global X Funds 0.03% 146,249 NS April 30, 2026 N-PORT
ISCB · iShares Trust 0.03% 15,580 SH Aug. 8, 2026 Daily
SCHA · SCHWAB STRATEGIC TRUST 0.03% 1,615,534 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.02% 12,416 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.02% 4,303,944 SH Aug. 8, 2026 Daily
VBR · VANGUARD INDEX FUNDS 0.02% 3,089,380 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.02% 1,053,780 SH Aug. 8, 2026 Daily
WSML · iShares Trust 0.02% 21,537 SH Aug. 8, 2026 Daily
TMFE · RBB Fund, Inc. 0.02% 3,704 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.02% 140,923 NS April 30, 2026 N-PORT
DXUV · Dimensional ETF Trust 0.02% 18,065 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.01% 12,558 NS May 31, 2026 N-PORT
TILT · FlexShares Trust 0.01% 71,148 NS April 30, 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0.01% 4,849,607 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 12,045 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.01% 315 NS May 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.01% 44,207 NS April 30, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.00% 125,344 NS May 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.00% 146,278 NS April 30, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 482,457 NS April 30, 2026 N-PORT
ITOT · iShares Trust 0.00% 510,986 SH Aug. 8, 2026 Daily
AVUS · AMERICAN CENTURY ETF TRUST 0.00% 89,379 NS May 31, 2026 N-PORT
DFSU · Dimensional ETF Trust 0.00% 16,834 NS April 30, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 128,547 NS April 30, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 224,829 NS May 31, 2026 N-PORT
IWV · iShares Trust 0.00% 64,557 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 13,489,795 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 32,806 SH Aug. 8, 2026 Daily