SVRA Savara, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$5.40
Price · Aug 18, 2026
Fundamentals as of Aug 11, 2026
52W Range
$3–$7
61% of range
Analyst Rating
BUY
14 analysts
Price Target
$11
+103% upside
P/E (TTM)
-10.2
ROE
-73.4%
Net Profit Margin
—

SVRA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$5.40
Market Cap
$1.11B
P/E (TTM)
-10.2
EPS (TTM)
$-0.53
Revenue (TTM)
—
Div Yield
—
ROE
-73.4%
Debt/Equity
0.1
52W Range
$3 – $7

SVRA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income —
4-point trend, -35.8%
2016-12-31 → 2020-12-31
EPS $-0.53
5-point trend, -65.6%
2021-12-31 → 2025-12-31
Free Cash Flow $-101M
9-point trend, -171.1%
2016-12-31 → 2025-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SVRA
Peer Median
P/E (TTM)
5-point trend, -193.6%
-10.2
—
P/B
5-point trend, +527.8%
5.4
5.2
EV / EBITDA
4-point trend, -5758.2%
-7.3
—
Price / FCF
5-point trend, -681.7%
-10.9
—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SVRA
Peer Median
ROA
5-point trend, -20.2%
-51.0%
-44.7%
ROE
5-point trend, -4.4%
-73.4%
-51.5%
ROIC
4-point trend, +84.9%
-53.0%
—

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SVRA
Peer Median
Debt / Equity
4-point trend, -17.1%
0.1
0.0
Current Ratio
5-point trend, +13.8%
11.8
9.5
Quick Ratio
5-point trend, +14.9%
11.6
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SVRA
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SVRA
Peer Median
EPS (Diluted)
5-point trend, -65.6%
$-0.53
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SVRA
Peer Median

SVRA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 14 analysts
  • Strong Buy 5 35.7%
  • Buy 8 57.1%
  • Hold 1 7.1%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

8 analysts · 2026-08-17
Median target $10.25 +89.8%
Mean target $10.94 +102.5%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.01%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.15 $-0.14 -0.01%
Dec. 31, 2025 $-0.13 $-0.12 -0.01%
Sept. 30, 2025 $-0.14 $-0.14 -0.00%
June 30, 2025 $-0.14 $-0.12 -0.02%
March 31, 2025 $-0.12 $-0.13 0.01%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SVRA $1.23B -11.4 — — -73.4% —
REPL $633M -2.3 — — -146.2% —
VOR $506M -0.2 — — 83.4% —
SANA $1.09B -4.2 — — -172.3% —
AVTX $336M -3.1 -86.6% -132642.4% -83.4% —
ARDX $1.42B -22.4 22.1% -15.1% -40.2% —
ODTX — — — — — —
KURA $913M -3.3 25.2% -413.0% -116.2% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 6-point trend, +257000.00 · · · · · $257.0K $0 · $0 $400.0K $54.0K $0
SG&A Expense 12-point trend, +343.3% $42M $25M $16M $11M $12M $14M $13M $11M $11M $3M $2M $9M
Operating Expenses 12-point trend, +322.0% $124M $103M $60M $39M $41M $50M $79M $70M $30M $11M $6M $29M
Operating Income 12-point trend, -322.0% $-124M $-103M $-60M $-39M $-41M $-49M $-79M $-70M $-30M $-11M $-6M $-29M
Interest Expense 3-point trend, -55.1% · · · · · · · · $1M $452.0K $3M ·
Interest Income 3-point trend, +76.8% · · · · · · · · · $122.0K $130.0K $69.0K
Other Non-op 12-point trend, +827.2% $5M $7M $5M $689.0K $-2M $-315.0K $852.0K $1M $-3M $-332.0K $-3M $508.0K
Pretax Income 12-point trend, -314.0% $-119M $-96M $-55M $-38M $-43M $-50M $-78M $-69M $-33M $-11M $-9M $-29M
Income Tax 7-point trend, +0.00 $0 $9.0K · · · · · $-7M $-4M $-357.0K $0 $0
Net Income 12-point trend, -314.0% $-119M $-96M $-55M $-38M $-43M $-50M $-78M $-62M $-30M $-11M $-9M $-29M
EPS (Basic) 5-point trend, -65.6% $-0.53 $-0.48 $-0.33 $-0.25 $-0.32 · · · · · · ·
EPS (Diluted) 5-point trend, -65.6% $-0.53 $-0.48 $-0.33 $-0.25 $-0.32 · · · · · · ·
Shares (Basic) 5-point trend, +66.1% 222,387,531 198,191,936 165,204,652 152,771,817 133,919,145 · · · · · · ·
Shares (Diluted) 5-point trend, +66.1% 222,387,531 198,191,936 165,204,652 152,771,817 133,919,145 · · · · · · ·
EBITDA 11-point trend, -322.0% $-124M · $-60M $-39M $-41M $-49M $-78M $-70M $-30M $-36M $-39M $-29M
Balance Sheet 25
Annual Balance Sheet data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +161.5% $33M $15M $27M $52M $34M $23M $50M $24M $22M $13M $17M $13M
Short-term Investments 10-point trend, +202522000.00 $203M $181M $136M $74M $127M $59M $72M $87M $72M $0 · ·
Prepaid Expense 12-point trend, +430.9% $6M $6M $4M $3M $4M $3M $2M $3M $4M $840.0K $1M $1M
Current Assets 12-point trend, +313.7% $242M $202M $166M $129M $165M $85M $124M $113M $98M $15M $42M $58M
PP&E (Net) 12-point trend, -46.8% $100.0K $165.0K $270.0K $51.0K $73.0K $156.0K $352.0K $522.0K $925.0K $793.0K $226.0K $188.0K
PP&E (Gross) 12-point trend, +357.3% $2M $2M $2M $2M $2M $2M $2M $2M $2M $1M $565.0K $532.0K
Accum. Depreciation 12-point trend, +578.2% $2M $2M $2M $2M $2M $2M $2M $1M $851.0K $504.0K $339.0K $344.0K
Goodwill 6-point trend, -100.0% · · · · · $0 · $27M $27M $3M $3M $3M
Other Non-current Assets 12-point trend, -76.2% $84.0K $242.0K $387.0K $116.0K $251.0K $250.0K $673.0K $131.0K $131.0K $131.0K $183.0K $353.0K
Total Assets 12-point trend, +259.5% $253M $213M $178M $140M $177M $98M $136M $152M $160M $29M $54M $70M
Accounts Payable 12-point trend, +320.2% $6M $5M $4M $1M $1M $3M $3M $4M $3M $536.0K $3M $1M
Accrued Liabilities 12-point trend, +160.2% $15M $10M $7M $5M $5M $6M $5M $3M $3M $2M $8M $6M
Current Liabilities 12-point trend, +141.7% $20M $15M $11M $6M $15M $8M $11M $7M $6M $3M $23M $8M
Capital Leases 9-point trend, +300.0% · $100.0K $200.0K $50.0K $100.0K $100.0K $300.0K · $297.0K $579.0K $25.0K ·
Deferred Tax 4-point trend, +111.0% · · · · · · · · $7M $2M $3M $3M
Other Non-current Liabilities 8-point trend, -100.0% $0 $87.0K $247.0K $54.0K $117.0K $84.0K $513.0K $70.0K · · · ·
Total Liabilities 12-point trend, +324.8% $50M $41M $37M $32M $32M $33M $35M $44M $40M $21M $30M $12M
Long-term Debt 6-point trend, +19.1% $30M $27M $26M $26M $26M $25M · · · · · ·
Total Debt 4-point trend, +16.6% $30M · $26M $26M $26M · · · · · · ·
Common Stock 12-point trend, +28.3% $204.0K $173.0K $140.0K $116.0K $116.0K $55.0K $52.0K $36.0K $32.0K $5.0K $164.0K $159.0K
Retained Earnings 12-point trend, -158.6% $-608M $-489M $-393M $-339M $-301M $-258M $-208M $-130M $-68M $-38M $-275M $-235M
AOCI 12-point trend, -248.0% $-87.0K $-750.0K $-271.0K $-605.0K $5.0K $942.0K $-17.0K $200.0K $958.0K $-591.0K $-17.0K $-25.0K
Stockholders' Equity 12-point trend, +1210.1% $203M $171M $140M $108M $144M $64M $102M $108M $119M $-36M $-27M $-18M
Liabilities + Equity 12-point trend, +259.5% $253M $213M $178M $140M $177M $98M $136M $152M $160M $29M $54M $70M
Shares Outstanding 12-point trend, +28.3% 204,567,283 172,423,223 138,143,545 114,046,345 114,036,892 54,152,955 50,790,441 35,146,096 30,509,522 3,162,573 163,614,297 159,458,376
Cash Flow 16
Annual Cash Flow data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
D&A 11-point trend, +2.4% $87.0K $130.0K $77.0K $31.0K $136.0K $255.0K $1M $526.0K · $99.0K $146.0K $85.0K
Stock-based Comp 12-point trend, +609.7% $14M $10M $4M $2M $3M $5M $4M $4M $552.0K $209.0K $153.0K $2M
Deferred Tax 3-point trend, -192.9% · · · · · · · $-7M $-3M $-2M · ·
Other Non-cash · · · · · · $28M · · · · ·
Operating Cash Flow 12-point trend, -310.0% $-101M $-89M $-51M $-35M $-40M $-40M $-45M $-39M $-28M $-8M $-5M $-25M
CapEx 12-point trend, -85.0% $22.0K $25.0K $296.0K $9.0K $57.0K $47.0K $148.0K $141.0K $495.0K $8.0K $165.0K $147.0K
Investing Cash Flow 9-point trend, +73.3% $-18M $-40M $-57M $53M $-69M $9M $16M $-14M $-69M · · ·
Debt Issued 2-point trend, +12.0% $30M · · $26M · · · · · · · ·
Net Debt Issued 3-point trend, +166.4% $2M · · $88.0K · · · · $-4M · · ·
Stock Issued 7-point trend, -92.4% · · · · · $2M $30M $505.0K $2M $20M $2M $30M
Net Stock Activity 7-point trend, -92.4% · · · · · $2M $30M $505.0K $2M $20M $2M $30M
Financing Cash Flow 9-point trend, +29.9% $138M $118M $83M $87.0K $121M $4M $55M $55M $106M · · ·
Net Change in Cash 12-point trend, +78.3% $18M $-11M $-26M $18M $11M $-27M $26M $2M $9M $-3M $4M $10M
Taxes Paid $0 · · · · · · · · · · ·
Free Cash Flow 11-point trend, -307.6% $-101M · $-51M $-35M $-40M $-40M $-45M $-39M $-29M $-37M $-33M $-25M
Levered FCF 2-point trend, +24.2% · · · · · · · · $-30M $-39M · ·
Profitability 7
Annual Profitability data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 2-point trend, +32.6% · · · · · -19182.9% · · · -28481.2% · ·
Net Margin 2-point trend, +31.5% · · · · · -19305.5% · · · -28203.1% · ·
Pretax Margin 2-point trend, +35.8% · · · · · -19305.5% · · · -30085.2% · ·
EBITDA Margin 2-point trend, +32.6% · · · · · -19182.9% · · · -28481.2% · ·
ROA 11-point trend, -11.7% -51.0% · -34.5% -24.1% -31.4% -42.4% -54.2% -39.4% -31.6% -100.1% -63.9% -45.6%
ROE 11-point trend, -36.2% -73.4% · -38.1% -34.0% -28.7% -70.4% -75.0% -54.4% -71.4% 410.9% -1425.5% -53.9%
ROIC 4-point trend, +84.9% -53.0% · · · · · · -56.9% -22.4% -350.2% · ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, +71.2% 11.8 · 15.7 22.0 11.3 10.4 11.4 15.6 16.3 2.5 1.8 6.9
Quick Ratio 11-point trend, +172.3% 11.6 · 15.3 21.5 11.0 10.1 11.2 15.3 15.7 1.8 1.0 4.2
Debt / Equity 4-point trend, -17.1% 0.1 · 0.2 0.2 0.2 · · · · · · ·
LT Debt / Equity 4-point trend, +22.8% 0.1 · 0.2 0.2 0.1 · · · · · · ·
Interest Coverage 3-point trend, +60.5% · · · · · · · · -25.8 -17.1 -65.3 ·
Efficiency 1
Annual Efficiency data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 6-point trend, +0.00 · · · · · 0.0 0.0 · 0.0 0.0 0.0 0.0
Per Share 4
Annual Per Share data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, +169.9% $0.99 · $1.02 $0.94 $1.27 $1.19 $2.00 $3.08 $3.91 $0.04 $0.15 $0.37
Cash Flow / Share 3-point trend, -100.8% $-0.45 · $-0.31 $-0.23 · · · · · · · ·
Cash / Share 11-point trend, -27.8% $0.16 · $0.19 $0.46 $0.30 $0.42 $0.98 $0.69 $0.73 $0.03 $0.14 $0.22
EPS (TTM) 5-point trend, -65.6% $-0.53 $-0.48 $-0.33 $-0.25 $-0.32 · · · · · · ·
Valuation (TTM) 13
Annual Valuation (TTM) data for SVRA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 6-point trend, +257000.00 · · · · · $257.0K $0 · $0 $400.0K $54.0K $0
Net Income TTM 12-point trend, -314.0% $-119M $-96M $-55M $-38M $-43M $-50M $-78M $-62M $-30M $-11M $-9M $-29M
Market Cap 8-point trend, +172.4% $1.23B · $649M $177M $141M $62M $228M $266M $453M · · ·
Enterprise Value 4-point trend, +17346.8% $1.03B · $513M $77M $6M · · · · · · ·
P/E 5-point trend, -193.6% -11.4 -6.4 -14.2 -6.2 -3.9 · · · · · · ·
P/S · · · · · 242.3 · · · · · ·
P/B 8-point trend, +60.0% 6.1 · 4.6 1.6 1.0 1.0 2.2 2.5 3.8 · · ·
P / Tangible Book 6-point trend, +527.8% 6.1 3.1 4.6 1.6 1.0 1.0 · · · · · ·
P / Cash Flow 8-point trend, +23.9% -12.2 · -12.7 -5.1 -3.5 -1.6 -5.0 -6.8 -16.0 · · ·
P / FCF 8-point trend, +22.5% -12.2 · -12.6 -5.1 -3.5 -1.6 -5.0 -6.7 -15.8 · · ·
EV / EBITDA 4-point trend, -5758.2% -8.3 · -8.6 -2.0 -0.1 · · · · · · ·
EV / FCF 4-point trend, -6827.7% -10.2 · -10.0 -2.2 -0.1 · · · · · · ·
Earnings Yield 5-point trend, +65.9% -8.8% -15.6% -7.0% -16.1% -25.8% · · · · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-119M$-96M$-55M$-38M$-43M
Diluted EPS $-0.53$-0.48$-0.33$-0.25$-0.32
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.1—0.20.20.2
Current Ratio 11.8—15.722.011.3
Quick Ratio 11.6—15.321.511.0
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-101M—$-51M$-35M$-40M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 197 filers · $1.2B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
32 (-23 vs prior Q) 25 (+6 vs prior Q) 69 (+7 vs prior Q) 54 (+13 vs prior Q) +12.4M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
NEA Management Company, LLC $150,742,986 24,471,264 12.35% Shares
Bain Capital Life Sciences Investors, LLC $108,419,826 17,600,621 8.88% Shares
Venrock Adviser, LLC $90,835,009 14,745,943 7.44% Shares
DEERFIELD MANAGEMENT COMPANY, L.P. $83,585,040 13,569,000 6.85% Shares
TCG Crossover Management, LLC $76,151,183 12,362,205 6.24% Shares
Frazier Life Sciences Management, L.P. $59,880,448 9,720,852 4.90% Shares
Polar Capital Holdings Plc $58,777,402 9,541,786 4.81% Shares
VANGUARD GROUP INC $54,222,146 8,992,064 4.44% Shares
VANGUARD CAPITAL MANAGEMENT LLC $48,864,477 7,932,545 4.00% Shares
Nantahala Capital Management, LLC $42,977,150 6,976,810 3.52% Shares
STATE STREET CORP $40,368,624 6,553,348 3.31% Shares
RTW INVESTMENTS, LP $36,666,661 5,952,380 3.00% Shares
Woodline Partners LP $26,149,933 4,245,119 2.14% Shares
ORBIMED ADVISORS LLC $24,392,984 3,959,900 2.00% Shares
Spruce Street Capital LP $21,267,868 3,452,576 1.74% Shares
GEODE CAPITAL MANAGEMENT, LLC $20,600,575 3,343,378 1.69% Shares
Rosalind Advisors, Inc. $19,577,225 3,178,121 1.60% Shares
EMERALD ADVISERS, LLC $19,394,384 3,148,439 1.59% Shares
Pictet Asset Management Holding SA $17,020,419 2,763,055 1.39% Shares
Vestal Point Capital, LP $16,755,200 2,720,000 1.37% Shares
Affinity Asset Advisors, LLC $15,474,862 2,512,153 1.27% Shares
EMERALD MUTUAL FUND ADVISERS TRUST $14,636,154 2,375,999 1.20% Shares
NAN FUNG TRINITY (HK) LTD $11,348,876 1,842,350 0.93% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $10,076,762 1,635,838 0.83% Shares
ADAR1 Capital Management, LLC $8,644,999 1,403,409 0.71% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $8,349,627 1,355,459 0.68% Shares
ALGERT GLOBAL LLC $8,188,235 1,329,259 0.67% Shares
WELLINGTON MANAGEMENT GROUP LLP $7,417,447 1,204,131 0.61% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $7,211,802 1,170,747 0.59% Shares
VANGUARD FIDUCIARY TRUST CO $6,412,597 1,041,006 0.53% Shares
Longaeva Partners L.P. $6,257,864 1,015,887 0.51% Shares
SUPERSTRING CAPITAL MANAGEMENT LP $6,021,154 977,460 0.49% Shares
MARSHALL WACE, LLP $5,458,967 886,196 0.45% Shares
SPHERA FUNDS MANAGEMENT LTD. $4,657,970 756,164 0.38% Shares
Swedbank AB $4,409,944 715,900 0.36% Shares
F/m Investments LLC $4,055,461 658,354 0.33% Shares
GOLDMAN SACHS GROUP INC $3,891,144 631,679 0.32% Shares
Sio Capital Management, LLC $3,804,878 617,675 0.31% Shares
AXA Investment Managers S.A. $3,760,142 1,053,261 0.31% Shares
KVP Capital Advisors, LP $3,728,525 605,280 0.31% Shares
Integral Health Asset Management, LLC $3,696,000 600,000 0.30% Shares
D. E. Shaw & Co., Inc. $3,120,890 506,638 0.26% Shares
Moody Aldrich Partners LLC $2,974,005 482,793 0.24% Shares
BANK OF AMERICA CORP /DE/ $2,811,837 456,467 0.23% Shares
Y-Intercept (Hong Kong) Ltd $2,529,351 410,609 0.21% Shares
Sofinnova Investments, Inc. $2,246,940 364,763 0.18% Shares
Seven Fleet Capital Management LP $1,904,074 309,103 0.16% Shares
WEDGE CAPITAL MANAGEMENT L L P/NC $1,681,669 307,998 0.14% Shares
RENAISSANCE TECHNOLOGIES LLC $1,533,156 248,889 0.13% Shares
Walleye Capital LLC $1,532,115 248,720 0.13% Shares
HighVista Strategies LLC $1,493,054 242,379 0.12% Shares
Eversept Partners, LP $1,259,276 204,428 0.10% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $1,236,693 205,090 0.10% Shares
VOYA INVESTMENT MANAGEMENT LLC $1,205,851 195,755 0.10% Shares
RHUMBLINE ADVISERS $1,146,187 186,071 0.09% Shares
Swiss National Bank $1,139,600 185,000 0.09% Shares
FMR LLC $1,064,676 172,837 0.09% Shares
CITADEL ADVISORS LLC $1,053,797 171,071 0.09% Shares
CITIGROUP INC $923,335 149,892 0.08% Shares
Jain Global LLC $879,605 142,793 0.07% Shares
WELLS FARGO & COMPANY/MN $859,708 139,563 0.07% Shares
XTX Topco Ltd $754,662 122,510 0.06% Shares
GLENMEDE TRUST CO NA $707,432 114,843 0.06% Shares
ALLIANCEBERNSTEIN L.P. $693,638 127,040 0.06% Shares
BlackRock, Inc. $646,196 104,902 0.05% Shares
DCF Advisers, LLC $616,000 100,000 0.05% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $585,921 95,117 0.05% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $574,728 93,300 0.05% Call option
Universal- Beteiligungs- und Servicegesellschaft mbH $554,400 90,000 0.05% Shares
MetLife Investment Management, LLC $549,817 89,256 0.05% Shares
Bank of New York Mellon Corp $549,330 89,177 0.04% Shares
Rafferty Asset Management, LLC $547,279 88,844 0.04% Shares
ENVESTNET ASSET MANAGEMENT INC $531,534 86,288 0.04% Shares
Cresset Asset Management, LLC $513,337 83,334 0.04% Shares
MORGAN STANLEY $496,096 80,535 0.04% Shares
Birchview Capital, LP $492,800 80,000 0.04% Shares
Vanguard Global Advisers, LLC $473,291 76,833 0.04% Shares
Connor, Clark & Lunn Investment Management Ltd. $461,236 74,876 0.04% Shares
Optimize Financial Inc $459,202 84,103 0.04% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $432,130 70,151 0.04% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $430,492 69,885 0.04% Shares
STATE OF WISCONSIN INVESTMENT BOARD $405,427 65,816 0.03% Shares
Susquehanna Portfolio Strategies, LLC $388,560 63,078 0.03% Shares
Virtus Investment Advisers, LLC $383,183 62,205 0.03% Shares
JPMORGAN CHASE & CO $382,459 63,426 0.03% Shares
Verdad Advisers, LP $380,435 61,759 0.03% Shares
Invesco Ltd. $375,526 60,962 0.03% Shares
FIFTH THIRD BANCORP $333,595 54,155 0.03% Shares
Avidity Partners Management LP $308,000 50,000 0.03% Shares
Sivia Capital Partners, LLC $298,760 48,500 0.02% Shares
VANGUARD ASSET MANAGEMENT, Ltd $293,450 47,638 0.02% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $285,824 46,400 0.02% Put option
PROFUND ADVISORS LLC $285,645 46,371 0.02% Shares
DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. $283,360 46,000 0.02% Shares
NEW YORK STATE COMMON RETIREMENT FUND $280,003 45,455 0.02% Shares
Jump Financial, LLC $273,504 44,400 0.02% Shares
SEI INVESTMENTS CO $267,523 43,429 0.02% Shares
CITADEL ADVISORS LLC $256,872 41,700 0.02% Put option
Police & Firemen's Retirement System of New Jersey $250,324 40,637 0.02% Shares
JANUS HENDERSON GROUP PLC $247,018 45,200 0.02% Shares

Company insiders 59 insiders · 30 officers · 25 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Matthew Pauls CHIEF EXECUTIVE OFFICER Dec. 16, 2025 G 1,188,050 0 0 $0
Robert N Neville Chief Executive Officer Dec. 20, 2019 A 498,028 0 0 $0
Brian M Culley CEO and Director Jan. 20, 2017 A 34,500 0 0 $0
Evan Levine CEO & President Feb. 8, 2008 P 4,395,000 0 0 $0
Nicholas J Virca CEO and President Dec. 15, 2003 X 347,956 0 0 $0
David L Lowrance Chief Financial Officer June 22, 2026 M 536,032 0 1 $-2,240,919
Brandi Roberts Chief Financial Officer & SVP Jan. 20, 2017 A 38,000 0 0 $0
Gregory P Hanson Senior VP, CFO & Treasurer Dec. 20, 2006 A — 0 0 $0
Carrie Carlander CFO, Treas, Secy, VP Finance Jan. 31, 2006 A 25,000 0 0 $0
Jaakko Taneli Jouhikainen President and Chief Operating Officer Dec. 20, 2019 A 167,569 0 0 $0
Patrick L Keran President & COO Jan. 2, 2015 A — 0 0 $0
James A Merritt President & Chf Med Officer Jan. 12, 2007 A — 0 0 $0
Robert Matthew Lutz Chief Fin. & Operating Officer July 15, 2026 A 328,977 0 0 $0
Kathleen R. Mccabe Chief Legal Officer Dec. 14, 2025 F 519,232 0 0 $0
Anne Erickson Chief Business Officer Dec. 14, 2025 F 371,712 0 0 $0
Yasmine Wasfi Chief Medical Officer Dec. 4, 2025 F 168,008 0 0 $0
Braden C. Parker Chief Commercial Officer Dec. 12, 2024 A 105,000 0 0 $0
Raymond Dennis Pratt Chief Medical Officer Dec. 12, 2024 A 340,050 0 0 $0
Badrul A. Chowdhury CHIEF MEDICAL OFFICER Dec. 14, 2021 A 300,000 0 0 $0
Shana Hood General Counsel & VP Jan. 20, 2017 A — 0 0 $0
Edwin L. Parsley Chief Medical Officer & SVP Jan. 20, 2017 A — 0 0 $0
Gregory D. Gorgas Senior VP, Commercial Jan. 4, 2016 A — 0 0 $0
Robert Martin Emanuele Senior VP, Development Jan. 4, 2016 A 294,598 0 0 $0
Santosh Vetticaden Chief Medical Officer & SVP June 19, 2014 A — 0 0 $0
Mark E. Erwin SVP, Operations Jan. 30, 2009 A — 0 0 $0
Michele Yelmene VP, Regulatory & QA Jan. 30, 2009 A — 0 0 $0
Joachim Ph Schupp VP, Medical Affairs March 31, 2008 A — 0 0 $0
Joan M Robbins SVP & Chief Science Officer March 31, 2008 A 146,500 0 0 $0
Mark Joseph Cantwell VP, Research & Development Jan. 12, 2007 A — 0 0 $0
Cellia Habita Senior VP, Clinical & Medical Oct. 7, 2004 P 5,000 0 0 $0
Joseph S Mccracken Director Feb. 16, 2026 M 302,644 0 0 $0
David A Ramsay Director Dec. 19, 2025 S 2,533,642 0 1 $-121,200
An Van Es-Johansson Director Dec. 9, 2025 A 102,500 0 0 $0
Nevan C Elam Director Dec. 9, 2025 A 106,887 0 0 $0
Richard J Hawkins Director Dec. 9, 2025 A 161,326 0 0 $0
Ricky Sun Director Dec. 14, 2023 A 22,500 0 0 $0
Yuri Pikover Director Dec. 13, 2018 A 153,734 0 0 $0
Peter Greenleaf Director Jan. 20, 2017 A — 0 0 $0
DITTRICH HOWARD Director Jan. 20, 2017 A — 0 0 $0
Lewis Shuster Director June 11, 2015 A — 0 0 $0
Jack Lief Director June 11, 2015 A — 0 0 $0
Ted W Love Director June 19, 2013 A — 0 0 $0
Odysseas D Kostas Director June 30, 2010 A — 0 0 $0
Eric K Rowinsky Director June 30, 2010 A — 0 0 $0
Mark Jerome Pykett Director June 30, 2010 A 8,000 0 0 $0
Michael M Goldberg Director June 30, 2010 A 26,000 0 0 $0
DENNER ALEXANDER J Director June 30, 2008 A — 0 0 $0
Mark Bagnall Director May 23, 2007 A — 0 0 $0
Ross M Johnson Director Dec. 21, 2006 X 1,621,779 0 0 $0
Meister, Keith A. Director June 2, 2006 A — 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 7 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Growth Equity Opportunities 17, LLC, New Enterprise Associates 17, L.P., NEA Partners 17, L.P., NEA 17 GP, LLC, Forest Baskett, Ali Behbahani, Carmen Chang, Anthony A. Florence, Jr., Mohamad H. Makhzoumi, Edward T. Mathers, Scott D. Sandell, Paul Walker, Rick Yang ×4 filings Nov. 14, 2025 12.00% Amendment Passive investment SEC
Bain Capital Life Sciences Fund II, L.P., BCIP Life Sciences Associates, LP, BCLS II Investco, LP ×5 filings March 27, 2025 9.99% Amendment — SEC
High River Limited Partnership, Hopper Investments LLC, Barberry Corp., Icahn Partners Master Fund LP, Icahn Offshore LP, Icahn Partners LP, Icahn Onshore LP, Icahn Capital LP, IPH GP LLC, Icahn Enterprises Holdings L.P., Icahn Enterprises G.P. Inc., Beckton Corp., Carl C. Icahn Dec. 30, 2015 — Initial filing — SEC
Evan M. Levine, Mark Capital, LLC Feb. 6, 2009 — Initial filing — SEC
Evan Levine, Mark Capital, LLC ×2 filings Dec. 19, 2007 — Initial filing — SEC
Matthew Balk ×2 filings June 1, 2006 — Initial filing Passive investment SEC
High River Limited Partnership S.S. OR, Hopper Investments LLC S.S. OR, Barberry Corp. S.S. OR, Icahn Partners Master Fund LP S.S. OR, Icahn Offshore LP S.S. OR, CCI Offshore Corp. S.S. OR, Icahn Partners LP S.S. OR, Icahn Onshore LP S.S. OR, CCI Onshore Corp. S.S. OR, Carl C. Icahn S.S. OR Aug. 5, 2005 — Initial filing Board campaign SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 38 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
LFSC · RBB Fund, Inc. 3.22% 651,024 NS May 31, 2026 N-PORT
BBC · ETFis Series Trust I 0.56% 39,885 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.21% 203,377 NS April 30, 2026 N-PORT
IWC · iShares Trust 0.20% 519,481 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.09% 301,950 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.08% 11,152 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.06% 163,980 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.06% 1,401,936 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.05% 7,524 NS May 31, 2026 N-PORT
IBB · iShares Trust 0.05% 777,564 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.03% 880,662 SH Aug. 8, 2026 Daily
NUSC · Nushares ETF Trust 0.03% 70,061 NS April 30, 2026 N-PORT
IWM · iShares Trust 0.03% 3,921,924 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.02% 62,952 NS April 30, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 105,661 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.02% 6,895 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.02% 33,621 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 646,784 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.01% 5,393 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.01% 1,567,813 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 277,850 SH Aug. 8, 2026 Daily
ISCV · iShares Trust 0.01% 11,041 SH Aug. 8, 2026 Daily
ISCB · iShares Trust 0.01% 4,332 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.01% 5,454 NS May 31, 2026 N-PORT
ISCG · iShares Trust 0.01% 12,910 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 9,739 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.01% 31,710 NS April 30, 2026 N-PORT
WSML · iShares Trust 0.00% 5,605 SH Aug. 8, 2026 Daily
TILT · FlexShares Trust 0.00% 18,178 NS April 30, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.00% 80,699 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 137 NS May 31, 2026 N-PORT
IWV · iShares Trust 0.00% 42,652 SH Aug. 8, 2026 Daily
ITOT · iShares Trust 0.00% 170,824 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.00% 80,211 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 23,796 NS April 30, 2026 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.00% 1,747 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 6,164,961 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 11,396 SH Aug. 8, 2026 Daily